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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2-hydroxy steroid
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Accession:CHEBI:36857 term browser browse the term
Definition:Any hydroxy steroid carrying a hydroxy group at position 2.
Synonyms:related_synonym: 2-hydroxy steroids


show annotations for term's descendants           Sort by:
2-hydroxy-17beta-estradiol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor affects binding EXP 2-hydroxyestradiol binds to AR protein CTD PMID:14565775 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Ccnd1 cyclin D1 increases expression ISO 2-hydroxyestradiol results in increased expression of CCND1 protein CTD PMID:23685341 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ckb creatine kinase B multiple interactions EXP 2-hydroxyestradiol inhibits the reaction [Estradiol results in increased expression of CKB] CTD PMID:10030690 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315 		JBrowse link
G Comt catechol-O-methyltransferase increases methylation
affects metabolic processing		 ISO
EXP		 COMT protein results in increased methylation of 2-hydroxyestradiol
COMT protein affects the metabolism of 2-hydroxyestradiol		 CTD PMID:11160877 PMID:15377160 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 affects chemical synthesis
multiple interactions		 ISO CYP1A1 protein affects the chemical synthesis of 2-hydroxyestradiol
[CYP1A1 protein results in increased oxidation of Estradiol] which results in increased chemical synthesis of 2-hydroxyestradiol; Resveratrol inhibits the reaction [CYP1A1 protein affects the chemical synthesis of 2-hydroxyestradiol]
2-hydroxyestradiol promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]		 CTD PMID:12093619 PMID:15142886 PMID:32781018 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases chemical synthesis
multiple interactions		 ISO CYP1A2 protein results in increased chemical synthesis of 2-hydroxyestradiol
Carbaryl inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of 2-hydroxyestradiol]; Chlorpyrifos inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of 2-hydroxyestradiol]; Fonofos inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of 2-hydroxyestradiol]; naphthalene inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of 2-hydroxyestradiol]		 CTD PMID:16790556 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO CYP1B1 protein affects the metabolism of [2-hydroxyestradiol co-treated with Glutathione] CTD PMID:14679015 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases chemical synthesis		 ISO Chlorpyrifos inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 2-hydroxyestradiol]; decamethrin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 2-hydroxyestradiol]; Fonofos inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 2-hydroxyestradiol]; Permethrin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 2-hydroxyestradiol] CTD PMID:16790556 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO 2-hydroxyestradiol inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein] CTD PMID:9048584 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
decreases expression		 EXP
ISO		 2-hydroxyestradiol inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein]
2-hydroxyestradiol results in decreased expression of ESR2 protein		 CTD PMID:9048584 PMID:23685341 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Foxo1 forkhead box O1 decreases expression ISO 2-hydroxyestradiol results in decreased expression of FOXO1 protein CTD PMID:23685341 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression
multiple interactions		 ISO 2-hydroxyestradiol results in increased expression of IGFBP1 mRNA
2-hydroxyestradiol promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of IGFBP1 mRNA]		 CTD PMID:32781018 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482 		JBrowse link
G Mt-atp6 mitochondrially encoded ATP synthase membrane subunit 6 increases expression ISO 2-hydroxyestradiol results in increased expression of ATP6 mRNA CTD PMID:9886577 NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599 		JBrowse link
G Mt-co3 mitochondrially encoded cytochrome c oxidase III increases expression ISO 2-hydroxyestradiol results in increased expression of COX3 mRNA CTD PMID:9886577 NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO 2-hydroxyestradiol results in increased expression of MYC protein CTD PMID:23685341 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Prl prolactin increases expression
multiple interactions		 ISO 2-hydroxyestradiol results in increased expression of PRL mRNA
2-hydroxyestradiol promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of PRL mRNA]		 CTD PMID:32781018 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA; Acetylcysteine inhibits the reaction [[2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA]; Acetylcysteine inhibits the reaction [Estradiol promotes the reaction [[2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA]]; BAY 11-7085 inhibits the reaction [[2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA]; BAY 11-7085 inhibits the reaction [Estradiol promotes the reaction [[2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA]]; Estradiol promotes the reaction [[2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA] CTD PMID:18480072 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Shbg sex hormone binding globulin increases expression ISO 2-hydroxyestradiol results in increased expression of SHBG mRNA; 2-hydroxyestradiol results in increased expression of SHBG protein CTD PMID:21793624 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 affects sulfation
increases sulfation		 ISO SULT1A1 gene polymorphism affects the sulfation of 2-hydroxyestradiol
SULT1A1 protein results in increased sulfation of 2-hydroxyestradiol		 CTD PMID:16517757 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 affects sulfation ISO 2-hydroxyestradiol affects the sulfation of SULT1E1 protein CTD PMID:11358677 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of 2-hydroxyestradiol CTD PMID:14871858 PMID:15117964 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of 2-hydroxyestradiol CTD PMID:15117964 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
2-hydroxyestrone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ckb creatine kinase B multiple interactions EXP 2-hydroxyestrone inhibits the reaction [Estradiol results in increased expression of CKB] CTD PMID:10030690 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315 		JBrowse link
G Esr1 estrogen receptor 1 affects binding
multiple interactions		 ISO 2-hydroxyestrone binds to ESR1 protein
2-hydroxyestrone binds to and results in increased activity of ESR1 protein		 CTD PMID:16728493 PMID:17713618 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO 2-hydroxyestrone binds to and results in increased activity of ESR2 protein CTD PMID:17713618 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression ISO 2-hydroxyestrone results in decreased expression of FSHB protein CTD PMID:6401747 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression ISO 2-hydroxyestrone results in decreased expression of LHB protein CTD PMID:6401747 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of 2-hydroxyestrone CTD PMID:15117964 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of 2-hydroxyestrone CTD PMID:15117964 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of 2-hydroxyestrone CTD PMID:15117964 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
20-hydroxyecdysone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein] CTD PMID:26048653 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Ecdysterone results in increased expression of BAX protein CTD PMID:33878320 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression ISO Ecdysterone affects the expression of BCL2 protein CTD PMID:33878320 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage		 ISO Ecdysterone results in increased activity of CASP3 protein
Ecdysterone results in increased cleavage of CASP3 protein		 CTD PMID:29126784 PMID:33878320 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein]]; Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein] CTD PMID:26048653 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein] CTD PMID:26048653 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression
increases expression		 ISO Ecdysterone results in decreased expression of HSPA5 protein
Ecdysterone results in increased expression of HSPA5 mRNA		 CTD PMID:29126784 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Mtor mechanistic target of rapamycin kinase affects expression ISO Ecdysterone affects the expression of MTOR protein CTD PMID:33878320 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases response to substance		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]
NFE2L2 results in increased susceptibility to Ecdysterone		 CTD PMID:26048653 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Ecdysterone results in increased cleavage of PARP1 protein CTD PMID:33878320 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Sqstm1 sequestosome 1 affects expression ISO Ecdysterone affects the expression of SQSTM1 protein CTD PMID:33878320 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
brassinolide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases expression ISO brassinolide results in decreased expression of BCL2 protein CTD PMID:17557751 PMID:20833159 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO brassinolide results in decreased expression of BCL2L1 protein CTD PMID:20833159 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bid BH3 interacting domain death agonist decreases expression ISO brassinolide results in decreased expression of BID protein CTD PMID:20833159 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Casp3 caspase 3 increases activity
increases expression		 ISO brassinolide results in increased activity of CASP3 protein
brassinolide results in increased expression of CASP3 protein modified form		 CTD PMID:17557751 PMID:20833159 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO brassinolide results in decreased expression of CCNB1 protein CTD PMID:20833159 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO brassinolide results in decreased expression of CCND1 protein CTD PMID:20833159 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 decreases expression ISO brassinolide results in decreased expression of CCNE1 protein CTD PMID:20833159 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO brassinolide results in decreased expression of CDK2 protein CTD PMID:20833159 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO brassinolide results in decreased expression of CDK4 protein CTD PMID:20833159 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO brassinolide results in increased expression of CDKN1A protein CTD PMID:20833159 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO brassinolide results in decreased expression of CDKN1B protein CTD PMID:20833159 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO brassinolide results in decreased expression of ESR1 CTD PMID:20833159 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 affects localization
decreases expression		 ISO brassinolide affects the localization of ESR2 protein
brassinolide results in decreased expression of ESR2		 CTD PMID:20833159 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Mdm2 MDM2 proto-oncogene decreases expression ISO brassinolide results in decreased expression of MDM2 protein CTD PMID:20833159 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO brassinolide results in decreased expression of RB1 protein; brassinolide results in decreased expression of RB1 protein modified form CTD PMID:20833159 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO brassinolide results in increased expression of TP53 protein CTD PMID:20833159 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
digitonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh5 cadherin 5 multiple interactions ISO Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein] CTD PMID:31404653 NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368 		JBrowse link
G Etv2 ETS variant transcription factor 2 multiple interactions ISO Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein]; Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein] CTD PMID:31404653 NCBI chr 1:85,890,562...85,894,025
Ensembl chr 1:85,890,559...85,893,431 		JBrowse link
G Gata2 GATA binding protein 2 multiple interactions ISO Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein]; Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein] CTD PMID:31404653 NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression ISO Digitonin results in decreased expression of HIF1A protein CTD PMID:34717917 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Digitonin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Spn sialophorin multiple interactions ISO Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein] CTD PMID:31404653 NCBI chr 1:181,746,937...181,759,564
Ensembl chr 1:181,746,429...181,759,628 		JBrowse link
ponasterone A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 decreases activity
multiple interactions		 EXP ponasterone A results in decreased activity of CASP3 protein
L-161982 inhibits the reaction [ponasterone A results in decreased activity of CASP3 protein]		 CTD PMID:16396944 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase affects expression ISO ponasterone A affects the expression of FHIT protein CTD PMID:17019711 NCBI chr15:13,935,029...15,442,620
Ensembl chr15:13,934,995...15,442,340 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 EXP L-161982 inhibits the reaction [ponasterone A results in increased expression of PTGS2 protein] CTD PMID:16396944 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases expression ISO ponasterone A results in increased expression of UGT1A3 protein CTD PMID:17058234 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19740
    chemical entity 19738
      molecular entity 19738
        polyatomic entity 19698
          heteroatomic molecular entity 19650
            hydroxides 19255
              organic hydroxy compound 18867
                hydroxy steroid 14085
                  2-hydroxy steroid 54
                    2-hydroxy-17beta-estradiol + 22
                    2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronide) 0
                    2-hydroxy-17beta-estradiol 3-sulfate 0
                    2-hydroxy-3-O-methyl estrone 0
                    2-hydroxyestradiol 3-methyl ether 0
                    2-hydroxyestrone + 8
                    2-hydroxyestrone 3-O-(beta-D-glucuronide) 0
                    2-hydroxytestosterone + 0
                    2alpha-hydroxy steroid + 22
                    2beta-hydroxy steroid + 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19740
    subatomic particle 19738
      composite particle 19738
        hadron 19738
          baryon 19738
            nucleon 19738
              atomic nucleus 19738
                atom 19738
                  main group element atom 19686
                    p-block element atom 19686
                      carbon group element atom 19631
                        carbon atom 19627
                          organic molecular entity 19627
                            organic molecule 19587
                              organic cyclic compound 19393
                                organic polycyclic compound 17178
                                  steroid 14369
                                    hydroxy steroid 14085
                                      2-hydroxy steroid 54
                                        2-hydroxy-17beta-estradiol + 22
                                        2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronide) 0
                                        2-hydroxy-17beta-estradiol 3-sulfate 0
                                        2-hydroxy-3-O-methyl estrone 0
                                        2-hydroxyestradiol 3-methyl ether 0
                                        2-hydroxyestrone + 8
                                        2-hydroxyestrone 3-O-(beta-D-glucuronide) 0
                                        2-hydroxytestosterone + 0
                                        2alpha-hydroxy steroid + 22
                                        2beta-hydroxy steroid + 14
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