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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:26-hydroxy steroid
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Accession:CHEBI:36852 term browser browse the term
Definition:Any hydroxy steroid in which a hydroxy group is located at position 26.
Synonyms:related_synonym: 26-hydroxy steroids

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(25R)-cholest-5-ene-3beta,26-diol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions
increases expression		 ISO
EXP		 Docosahexaenoic Acids inhibits the reaction [27-hydroxycholesterol results in increased expression of ABCA1 mRNA]; Linoleic Acid inhibits the reaction [27-hydroxycholesterol results in increased expression of ABCA1 mRNA]; Oleic Acid inhibits the reaction [27-hydroxycholesterol results in increased expression of ABCA1 mRNA]
27-hydroxycholesterol results in increased expression of ABCA1 mRNA; 27-hydroxycholesterol results in increased expression of ABCA1 protein
[Fingolimod Hydrochloride results in increased abundance of 27-hydroxycholesterol] which results in increased expression of ABCA1 mRNA		 CTD PMID:15148325 PMID:17088262 PMID:18356535 PMID:18841091 PMID:20056921 PMID:28167099 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 increases expression ISO 27-hydroxycholesterol results in increased expression of ABCG1 protein CTD PMID:17088262 NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489 		JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO 27-hydroxycholesterol promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]; 27-hydroxycholesterol promotes the reaction [STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]] CTD PMID:20083572 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875 		JBrowse link
G Apoe apolipoprotein E increases expression EXP 27-hydroxycholesterol results in increased expression of APOE mRNA; 27-hydroxycholesterol results in increased expression of APOE protein CTD PMID:28167099 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057 		JBrowse link
G App amyloid beta precursor protein multiple interactions
decreases secretion
increases expression		 ISO 27-hydroxycholesterol results in decreased metabolism of and results in decreased secretion of APP protein
27-hydroxycholesterol results in decreased secretion of APP protein alternative form
27-hydroxycholesterol results in increased expression of APP protein alternative form		 CTD PMID:15148325 PMID:19126211 PMID:19158428 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Arc activity-regulated cytoskeleton-associated protein decreases expression EXP 27-hydroxycholesterol results in decreased expression of ARC protein CTD PMID:18503570 NCBI chr 7:115,907,097...115,911,059
Ensembl chr 7:115,907,097...115,910,541 		JBrowse link
G Bace1 beta-secretase 1 increases expression ISO 27-hydroxycholesterol results in increased expression of BACE1 protein CTD PMID:19126211 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression		 ISO [24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CCL2 mRNA; Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of CCL2 mRNA]; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CCL2 mRNA] CTD PMID:24802026 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression
increases secretion		 ISO 27-hydroxycholesterol results in increased expression of CCL3 mRNA
27-hydroxycholesterol results in increased secretion of CCL3 protein		 CTD PMID:24370436 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases secretion
increases expression		 ISO 27-hydroxycholesterol results in increased secretion of CCL4 protein
27-hydroxycholesterol results in increased expression of CCL4 mRNA		 CTD PMID:24370436 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355 		JBrowse link
G Ccn5 cellular communication network factor 5 multiple interactions
increases expression		 ISO Fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased expression of CCN5 mRNA] CTD PMID:17872378 NCBI chr 3:160,207,969...160,219,316
Ensembl chr 3:160,207,913...160,219,331 		JBrowse link
G Cd36 CD36 molecule increases expression
multiple interactions		 ISO 27-hydroxycholesterol results in increased expression of CD36 mRNA
[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CD36 mRNA; Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of CD36 mRNA]; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CD36 mRNA]; Quercetin inhibits the reaction [27-hydroxycholesterol results in increased expression of CD36 mRNA]; Quercetin inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CD36 mRNA]		 CTD PMID:24802026 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749 		JBrowse link
G Ces1d carboxylesterase 1D decreases activity
multiple interactions		 ISO 27-hydroxycholesterol results in decreased activity of CES1 protein
27-hydroxycholesterol inhibits the reaction [CES1 protein results in increased metabolism of bioresmethrin]		 CTD PMID:19761868 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression
multiple interactions		 ISO 27-hydroxycholesterol results in increased expression of CXCL12 mRNA
fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased expression of CXCL12 mRNA]		 CTD PMID:17872378 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases abundance
multiple interactions
increases chemical synthesis		 ISO
EXP		 CYP27A1 protein results in increased abundance of 27-hydroxycholesterol
[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol
CYP27A1 protein results in increased chemical synthesis of 27-hydroxycholesterol
[[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol] which results in increased activity of HMGCR protein; [CYP27A1 protein results in increased hydroxylation of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol; [CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol; [CYP27A1 protein results in increased oxidation of 27-hydroxycholesterol] which results in increased chemical synthesis of 3-hydroxy-5-cholestenoic acid; [TGFB1 protein results in increased expression of CYP27A1 protein] which results in increased abundance of 27-hydroxycholesterol		 CTD PMID:8496670 PMID:9215552 PMID:9660774 PMID:11408283 PMID:11714861 PMID:12119285 PMID:12531903 PMID:14622972 PMID:15708352 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases metabolic processing ISO
EXP		 CYP7A1 protein results in increased metabolism of 27-hydroxycholesterol CTD PMID:10882719 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431 		JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 increases hydroxylation
increases metabolic processing
increases abundance		 ISO CYP7B1 protein results in increased hydroxylation of 27-hydroxycholesterol
CYP7B1 protein results in increased metabolism of 27-hydroxycholesterol
CYP7B1 gene mutant form results in increased abundance of 27-hydroxycholesterol		 CTD PMID:10588945 PMID:10748047 NCBI chr 2:102,701,903...102,871,257
Ensembl chr 2:102,701,903...102,871,257 		JBrowse link
G E2f1 E2F transcription factor 1 increases expression ISO 27-hydroxycholesterol results in increased expression of E2F1 mRNA CTD PMID:17872378 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 decreases expression ISO 27-hydroxycholesterol results in decreased expression of ERBB4 mRNA CTD PMID:17872378 NCBI chr 9:75,021,790...76,178,936
Ensembl chr 9:75,021,790...75,528,644 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
affects response to substance
increases degradation		 ISO 27-hydroxycholesterol binds to and affects the folding of and results in increased activity of ESR1 protein; 27-hydroxycholesterol binds to and results in decreased activity of ESR1 protein; 27-hydroxycholesterol inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein]; 27-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; 27-hydroxycholesterol promotes the reaction [ESR1 protein binds to TFF1 promoter]; fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased activity of ESR1 protein]
ESR1 protein affects the susceptibility to 27-hydroxycholesterol
ESR1 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS2 mRNA]; ESR1 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS3 mRNA]
27-hydroxycholesterol results in increased degradation of ESR1 protein		 CTD PMID:17872378 PMID:17873880 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects response to substance		 ISO 27-hydroxycholesterol binds to and affects the folding of and results in increased activity of ESR2 protein; 27-hydroxycholesterol binds to and results in decreased activity of ESR2 protein; 27-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR2 protein]
ESR2 protein affects the susceptibility to 27-hydroxycholesterol
ESR2 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS2 mRNA]; ESR2 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS3 mRNA]		 CTD PMID:17872378 PMID:17873880 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 decreases expression EXP 27-hydroxycholesterol results in decreased expression of GRIN1 protein CTD PMID:18503570 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A decreases phosphorylation EXP 27-hydroxycholesterol results in decreased phosphorylation of GRIN2A protein CTD PMID:18503570 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression ISO 27-hydroxycholesterol results in increased expression of HIF1A protein CTD PMID:27856279 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases activity
decreases expression
multiple interactions		 ISO
EXP		 27-hydroxycholesterol metabolite results in decreased activity of HMGCR protein; 27-hydroxycholesterol results in decreased activity of HMGCR protein
27-hydroxycholesterol results in decreased expression of HMGCR mRNA; 27-hydroxycholesterol results in decreased expression of HMGCR protein
[[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol] which results in increased activity of HMGCR protein; Dehydroepiandrosterone inhibits the reaction [27-hydroxycholesterol results in decreased activity of HMGCR protein]; Pregnenolone inhibits the reaction [27-hydroxycholesterol results in decreased activity of HMGCR protein]		 CTD PMID:7749852 PMID:7751816 PMID:7788503 PMID:9059514 PMID:11408283 PMID:18024962 PMID:28167099 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO 27-hydroxycholesterol results in increased expression of ICAM1 mRNA CTD PMID:19426978 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 27-hydroxycholesterol promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:11851725 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 increases secretion
increases expression
multiple interactions		 ISO 27-hydroxycholesterol results in increased secretion of IL6 protein
27-hydroxycholesterol results in increased expression of IL6 mRNA
Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased expression of IL6 mRNA]; Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased secretion of IL6 protein]; IL6 protein affects the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [27-hydroxycholesterol results in increased expression of IL6 mRNA]; stattic inhibits the reaction [27-hydroxycholesterol results in increased secretion of IL6 protein]		 CTD PMID:11851725 PMID:28739487 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Itgb1 integrin subunit beta 1 multiple interactions
increases expression		 ISO [24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA; Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of ITGB1 mRNA]; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA]; Quercetin inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA] CTD PMID:24802026 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535 		JBrowse link
G Lcat lecithin cholesterol acyltransferase increases metabolic processing ISO LCAT protein results in increased metabolism of 27-hydroxycholesterol CTD PMID:7744831 NCBI chr19:37,913,333...37,916,799
Ensembl chr19:37,913,336...37,916,813 		JBrowse link
G Ldlr low density lipoprotein receptor decreases activity
decreases expression		 ISO
EXP		 27-hydroxycholesterol results in decreased activity of LDLR protein
27-hydroxycholesterol results in decreased expression of LDLR mRNA; 27-hydroxycholesterol results in decreased expression of LDLR protein		 CTD PMID:8820113 PMID:28167099 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903 		JBrowse link
G Lipe lipase E, hormone sensitive type multiple interactions ISO LIPE protein promotes the reaction [27-hydroxycholesterol results in increased expression of STAR mRNA]; LIPE protein promotes the reaction [27-hydroxycholesterol results in increased expression of STAR protein] CTD PMID:23362264 NCBI chr 1:82,248,031...82,266,727
Ensembl chr 1:82,248,046...82,266,727 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
multiple interactions		 ISO 27-hydroxycholesterol results in increased expression of MMP9 mRNA
Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of MMP9 mRNA]		 CTD PMID:24802026 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression		 ISO 27-hydroxycholesterol inhibits the reaction [Estradiol results in increased expression of NOS2 mRNA]; ESR1 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS2 mRNA]; ESR2 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS2 mRNA] CTD PMID:17873880 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nos3 nitric oxide synthase 3 decreases expression
multiple interactions		 ISO 27-hydroxycholesterol results in decreased expression of NOS3 mRNA
27-hydroxycholesterol inhibits the reaction [Estradiol results in increased expression of NOS3 mRNA]; ESR1 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS3 mRNA]; ESR2 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS3 mRNA]		 CTD PMID:17873880 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410 		JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 affects abundance ISO NPC1 protein affects the abundance of 27-hydroxycholesterol CTD PMID:18483620 NCBI chr18:3,616,878...3,662,656
Ensembl chr18:3,616,878...3,662,683 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression EXP 27-hydroxycholesterol results in increased expression of NR1H3 mRNA; 27-hydroxycholesterol results in increased expression of NR1H3 protein CTD PMID:28167099 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750 		JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 increases activity
multiple interactions		 ISO 27-hydroxycholesterol results in increased activity of NR5A1 protein
27-hydroxycholesterol promotes the reaction [NR5A1 protein results in increased expression of STAR protein]		 CTD PMID:9144161 PMID:9804848 NCBI chr 3:22,998,900...23,020,441
Ensembl chr 3:22,999,616...23,020,441 		JBrowse link
G Pgr progesterone receptor increases expression
multiple interactions		 ISO 27-hydroxycholesterol results in increased expression of PGR mRNA; 27-hydroxycholesterol results in increased expression of PGR protein
fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased expression of PGR mRNA]		 CTD PMID:17872378 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression EXP 27-hydroxycholesterol results in increased expression of PPARG mRNA; 27-hydroxycholesterol results in increased expression of PPARG protein CTD PMID:28167099 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Ptges prostaglandin E synthase increases expression
multiple interactions		 ISO 27-hydroxycholesterol results in increased expression of PTGES mRNA
Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of PTGES mRNA]; Quercetin inhibits the reaction [27-hydroxycholesterol results in increased expression of PTGES mRNA]		 CTD PMID:24802026 NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 ISO 27-hydroxycholesterol results in increased expression of PTGS2 protein
[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of PTGS2 protein		 CTD PMID:24802026 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Sele selectin E increases expression ISO 27-hydroxycholesterol results in increased expression of SELE mRNA CTD PMID:19426978 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341 		JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2 decreases activity ISO 27-hydroxycholesterol results in decreased activity of SMPD2 protein CTD PMID:15261762 NCBI chr20:46,212,070...46,215,183
Ensembl chr20:46,211,892...46,215,120 		JBrowse link
G Snca synuclein alpha increases expression ISO 27-hydroxycholesterol results in increased expression of SNCA mRNA; 27-hydroxycholesterol results in increased expression of SNCA protein CTD PMID:18841091 PMID:19014385 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase decreases activity EXP 27-hydroxycholesterol results in decreased activity of SRC protein CTD PMID:18503570 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression EXP 27-hydroxycholesterol results in decreased expression of SREBF1 mRNA; 27-hydroxycholesterol results in decreased expression of SREBF1 protein CTD PMID:28167099 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions
increases abundance
increases expression		 ISO
EXP		 27-hydroxycholesterol promotes the reaction [NR5A1 protein results in increased expression of STAR protein]
STAR protein results in increased abundance of 27-hydroxycholesterol
27-hydroxycholesterol promotes the reaction [STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]]; LIPE protein promotes the reaction [27-hydroxycholesterol results in increased expression of STAR mRNA]; LIPE protein promotes the reaction [27-hydroxycholesterol results in increased expression of STAR protein]
27-hydroxycholesterol results in increased expression of STAR mRNA; 27-hydroxycholesterol results in increased expression of STAR protein		 CTD PMID:9804848 PMID:12368294 PMID:15863358 PMID:20083572 PMID:23362264 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases phosphorylation		 ISO Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]; STAT3 protein promotes the reaction [27-hydroxycholesterol results in increased expression of VEGFA mRNA]; STAT3 protein promotes the reaction [27-hydroxycholesterol results in increased secretion of VEGFA protein]
Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]; IL6 protein affects the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]		 CTD PMID:27856279 PMID:28739487 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233 		JBrowse link
G Tff1 trefoil factor 1 multiple interactions
increases expression		 ISO 27-hydroxycholesterol promotes the reaction [ESR1 protein binds to TFF1 promoter]; fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased expression of TFF1 mRNA] CTD PMID:17872378 PMID:27856279 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [TGFB1 protein results in increased expression of CYP27A1 protein] which results in increased abundance of 27-hydroxycholesterol CTD PMID:15708352 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tlr4 toll-like receptor 4 increases expression
multiple interactions		 ISO 27-hydroxycholesterol results in increased expression of TLR4 mRNA
[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of TLR4 mRNA; Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of TLR4 mRNA]; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of TLR4 mRNA]; Quercetin inhibits the reaction [27-hydroxycholesterol results in increased expression of TLR4 mRNA]; Quercetin inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of TLR4 mRNA]		 CTD PMID:24802026 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression ISO 27-hydroxycholesterol results in increased expression of VCAM1 mRNA CTD PMID:19426978 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases secretion
increases expression		 ISO Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased expression of VEGFA mRNA]; Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased secretion of VEGFA protein]; STAT3 protein promotes the reaction [27-hydroxycholesterol results in increased expression of VEGFA mRNA]; STAT3 protein promotes the reaction [27-hydroxycholesterol results in increased secretion of VEGFA protein] CTD PMID:27856279 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
26-hydroxycholesterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression
multiple interactions		 ISO
EXP		 27-hydroxycholesterol results in increased expression of ABCA1 mRNA; 27-hydroxycholesterol results in increased expression of ABCA1 protein
[Fingolimod Hydrochloride results in increased abundance of 27-hydroxycholesterol] which results in increased expression of ABCA1 mRNA
Docosahexaenoic Acids inhibits the reaction [27-hydroxycholesterol results in increased expression of ABCA1 mRNA]; Linoleic Acid inhibits the reaction [27-hydroxycholesterol results in increased expression of ABCA1 mRNA]; Oleic Acid inhibits the reaction [27-hydroxycholesterol results in increased expression of ABCA1 mRNA]		 CTD PMID:15148325 PMID:17088262 PMID:18356535 PMID:18841091 PMID:20056921 PMID:28167099 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 increases expression ISO 27-hydroxycholesterol results in increased expression of ABCG1 protein CTD PMID:17088262 NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489 		JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO 27-hydroxycholesterol promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]; 27-hydroxycholesterol promotes the reaction [STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]] CTD PMID:20083572 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875 		JBrowse link
G Apoe apolipoprotein E increases expression EXP 27-hydroxycholesterol results in increased expression of APOE mRNA; 27-hydroxycholesterol results in increased expression of APOE protein CTD PMID:28167099 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057 		JBrowse link
G App amyloid beta precursor protein multiple interactions
increases expression
decreases secretion		 ISO 27-hydroxycholesterol results in decreased metabolism of and results in decreased secretion of APP protein
27-hydroxycholesterol results in increased expression of APP protein alternative form
27-hydroxycholesterol results in decreased secretion of APP protein alternative form		 CTD PMID:15148325 PMID:19126211 PMID:19158428 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Arc activity-regulated cytoskeleton-associated protein decreases expression EXP 27-hydroxycholesterol results in decreased expression of ARC protein CTD PMID:18503570 NCBI chr 7:115,907,097...115,911,059
Ensembl chr 7:115,907,097...115,910,541 		JBrowse link
G Bace1 beta-secretase 1 increases expression ISO 27-hydroxycholesterol results in increased expression of BACE1 protein CTD PMID:19126211 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions		 ISO 27-hydroxycholesterol results in increased expression of CCL2 mRNA
[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CCL2 mRNA; Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of CCL2 mRNA]; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CCL2 mRNA]		 CTD PMID:24802026 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression
increases secretion		 ISO 27-hydroxycholesterol results in increased expression of CCL3 mRNA
27-hydroxycholesterol results in increased secretion of CCL3 protein		 CTD PMID:24370436 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases secretion
increases expression		 ISO 27-hydroxycholesterol results in increased secretion of CCL4 protein
27-hydroxycholesterol results in increased expression of CCL4 mRNA		 CTD PMID:24370436 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355 		JBrowse link
G Ccn5 cellular communication network factor 5 increases expression
multiple interactions		 ISO 27-hydroxycholesterol results in increased expression of CCN5 mRNA
Fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased expression of CCN5 mRNA]		 CTD PMID:17872378 NCBI chr 3:160,207,969...160,219,316
Ensembl chr 3:160,207,913...160,219,331 		JBrowse link
G Cd36 CD36 molecule multiple interactions
increases expression		 ISO [24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CD36 mRNA; Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of CD36 mRNA]; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CD36 mRNA]; Quercetin inhibits the reaction [27-hydroxycholesterol results in increased expression of CD36 mRNA]; Quercetin inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CD36 mRNA] CTD PMID:24802026 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749 		JBrowse link
G Ces1d carboxylesterase 1D multiple interactions
decreases activity		 ISO 27-hydroxycholesterol inhibits the reaction [CES1 protein results in increased metabolism of bioresmethrin]
27-hydroxycholesterol results in decreased activity of CES1 protein		 CTD PMID:19761868 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression
multiple interactions		 ISO 27-hydroxycholesterol results in increased expression of CXCL12 mRNA
fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased expression of CXCL12 mRNA]		 CTD PMID:17872378 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases abundance
increases chemical synthesis
multiple interactions		 ISO
EXP		 CYP27A1 protein results in increased abundance of 27-hydroxycholesterol
CYP27A1 protein results in increased chemical synthesis of 27-hydroxycholesterol
[[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol] which results in increased activity of HMGCR protein; [CYP27A1 protein results in increased hydroxylation of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol; [CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol; [CYP27A1 protein results in increased oxidation of 27-hydroxycholesterol] which results in increased chemical synthesis of 3-hydroxy-5-cholestenoic acid; [TGFB1 protein results in increased expression of CYP27A1 protein] which results in increased abundance of 27-hydroxycholesterol		 CTD PMID:8496670 PMID:9215552 PMID:9660774 PMID:11408283 PMID:11714861 PMID:12119285 PMID:12531903 PMID:14622972 PMID:15708352 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases metabolic processing ISO
EXP		 CYP7A1 protein results in increased metabolism of 27-hydroxycholesterol CTD PMID:10882719 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431 		JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 increases abundance
increases metabolic processing
increases hydroxylation		 ISO CYP7B1 gene mutant form results in increased abundance of 27-hydroxycholesterol
CYP7B1 protein results in increased metabolism of 27-hydroxycholesterol
CYP7B1 protein results in increased hydroxylation of 27-hydroxycholesterol		 CTD PMID:10588945 PMID:10748047 NCBI chr 2:102,701,903...102,871,257
Ensembl chr 2:102,701,903...102,871,257 		JBrowse link
G E2f1 E2F transcription factor 1 increases expression ISO 27-hydroxycholesterol results in increased expression of E2F1 mRNA CTD PMID:17872378 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 decreases expression ISO 27-hydroxycholesterol results in decreased expression of ERBB4 mRNA CTD PMID:17872378 NCBI chr 9:75,021,790...76,178,936
Ensembl chr 9:75,021,790...75,528,644 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
affects response to substance
increases degradation		 ISO 27-hydroxycholesterol binds to and affects the folding of and results in increased activity of ESR1 protein; 27-hydroxycholesterol binds to and results in decreased activity of ESR1 protein; 27-hydroxycholesterol inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein]; 27-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; 27-hydroxycholesterol promotes the reaction [ESR1 protein binds to TFF1 promoter]; fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased activity of ESR1 protein]
ESR1 protein affects the susceptibility to 27-hydroxycholesterol
ESR1 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS2 mRNA]; ESR1 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS3 mRNA]
27-hydroxycholesterol results in increased degradation of ESR1 protein		 CTD PMID:17872378 PMID:17873880 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects response to substance		 ISO 27-hydroxycholesterol binds to and affects the folding of and results in increased activity of ESR2 protein; 27-hydroxycholesterol binds to and results in decreased activity of ESR2 protein; 27-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR2 protein]
ESR2 protein affects the susceptibility to 27-hydroxycholesterol
ESR2 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS2 mRNA]; ESR2 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS3 mRNA]		 CTD PMID:17872378 PMID:17873880 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 decreases expression EXP 27-hydroxycholesterol results in decreased expression of GRIN1 protein CTD PMID:18503570 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A decreases phosphorylation EXP 27-hydroxycholesterol results in decreased phosphorylation of GRIN2A protein CTD PMID:18503570 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression ISO 27-hydroxycholesterol results in increased expression of HIF1A protein CTD PMID:27856279 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
decreases expression
decreases activity		 ISO
EXP		 [[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol] which results in increased activity of HMGCR protein; Dehydroepiandrosterone inhibits the reaction [27-hydroxycholesterol results in decreased activity of HMGCR protein]; Pregnenolone inhibits the reaction [27-hydroxycholesterol results in decreased activity of HMGCR protein]
27-hydroxycholesterol results in decreased expression of HMGCR mRNA; 27-hydroxycholesterol results in decreased expression of HMGCR protein
27-hydroxycholesterol metabolite results in decreased activity of HMGCR protein; 27-hydroxycholesterol results in decreased activity of HMGCR protein		 CTD PMID:7749852 PMID:7751816 PMID:7788503 PMID:9059514 PMID:11408283 PMID:18024962 PMID:28167099 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO 27-hydroxycholesterol results in increased expression of ICAM1 mRNA CTD PMID:19426978 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 27-hydroxycholesterol promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:11851725 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 increases secretion
multiple interactions
increases expression		 ISO 27-hydroxycholesterol results in increased secretion of IL6 protein
Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased expression of IL6 mRNA]; Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased secretion of IL6 protein]; IL6 protein affects the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [27-hydroxycholesterol results in increased expression of IL6 mRNA]; stattic inhibits the reaction [27-hydroxycholesterol results in increased secretion of IL6 protein]		 CTD PMID:11851725 PMID:28739487 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Itgb1 integrin subunit beta 1 multiple interactions
increases expression		 ISO [24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA; Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of ITGB1 mRNA]; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA]; Quercetin inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA] CTD PMID:24802026 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535 		JBrowse link
G Lcat lecithin cholesterol acyltransferase increases metabolic processing ISO LCAT protein results in increased metabolism of 27-hydroxycholesterol CTD PMID:7744831 NCBI chr19:37,913,333...37,916,799
Ensembl chr19:37,913,336...37,916,813 		JBrowse link
G Ldlr low density lipoprotein receptor decreases activity
decreases expression		 ISO
EXP		 27-hydroxycholesterol results in decreased activity of LDLR protein
27-hydroxycholesterol results in decreased expression of LDLR mRNA; 27-hydroxycholesterol results in decreased expression of LDLR protein		 CTD PMID:8820113 PMID:28167099 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903 		JBrowse link
G Lipe lipase E, hormone sensitive type multiple interactions ISO LIPE protein promotes the reaction [27-hydroxycholesterol results in increased expression of STAR mRNA]; LIPE protein promotes the reaction [27-hydroxycholesterol results in increased expression of STAR protein] CTD PMID:23362264 NCBI chr 1:82,248,031...82,266,727
Ensembl chr 1:82,248,046...82,266,727 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
increases expression		 ISO Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of MMP9 mRNA] CTD PMID:24802026 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression		 ISO 27-hydroxycholesterol inhibits the reaction [Estradiol results in increased expression of NOS2 mRNA]; ESR1 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS2 mRNA]; ESR2 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS2 mRNA] CTD PMID:17873880 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
decreases expression		 ISO 27-hydroxycholesterol inhibits the reaction [Estradiol results in increased expression of NOS3 mRNA]; ESR1 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS3 mRNA]; ESR2 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS3 mRNA] CTD PMID:17873880 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410 		JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 affects abundance ISO NPC1 protein affects the abundance of 27-hydroxycholesterol CTD PMID:18483620 NCBI chr18:3,616,878...3,662,656
Ensembl chr18:3,616,878...3,662,683 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression EXP 27-hydroxycholesterol results in increased expression of NR1H3 mRNA; 27-hydroxycholesterol results in increased expression of NR1H3 protein CTD PMID:28167099 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750 		JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 increases activity
multiple interactions		 ISO 27-hydroxycholesterol results in increased activity of NR5A1 protein
27-hydroxycholesterol promotes the reaction [NR5A1 protein results in increased expression of STAR protein]		 CTD PMID:9144161 PMID:9804848 NCBI chr 3:22,998,900...23,020,441
Ensembl chr 3:22,999,616...23,020,441 		JBrowse link
G Pgr progesterone receptor increases expression
multiple interactions		 ISO 27-hydroxycholesterol results in increased expression of PGR mRNA; 27-hydroxycholesterol results in increased expression of PGR protein
fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased expression of PGR mRNA]		 CTD PMID:17872378 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression EXP 27-hydroxycholesterol results in increased expression of PPARG mRNA; 27-hydroxycholesterol results in increased expression of PPARG protein CTD PMID:28167099 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Ptges prostaglandin E synthase increases expression
multiple interactions		 ISO 27-hydroxycholesterol results in increased expression of PTGES mRNA
Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of PTGES mRNA]; Quercetin inhibits the reaction [27-hydroxycholesterol results in increased expression of PTGES mRNA]		 CTD PMID:24802026 NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 ISO 27-hydroxycholesterol results in increased expression of PTGS2 protein
[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of PTGS2 protein		 CTD PMID:24802026 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Sele selectin E increases expression ISO 27-hydroxycholesterol results in increased expression of SELE mRNA CTD PMID:19426978 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341 		JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2 decreases activity ISO 27-hydroxycholesterol results in decreased activity of SMPD2 protein CTD PMID:15261762 NCBI chr20:46,212,070...46,215,183
Ensembl chr20:46,211,892...46,215,120 		JBrowse link
G Snca synuclein alpha increases expression ISO 27-hydroxycholesterol results in increased expression of SNCA mRNA; 27-hydroxycholesterol results in increased expression of SNCA protein CTD PMID:18841091 PMID:19014385 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase decreases activity EXP 27-hydroxycholesterol results in decreased activity of SRC protein CTD PMID:18503570 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression EXP 27-hydroxycholesterol results in decreased expression of SREBF1 mRNA; 27-hydroxycholesterol results in decreased expression of SREBF1 protein CTD PMID:28167099 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions
increases expression
increases abundance		 ISO
EXP		 27-hydroxycholesterol promotes the reaction [STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]]; LIPE protein promotes the reaction [27-hydroxycholesterol results in increased expression of STAR mRNA]; LIPE protein promotes the reaction [27-hydroxycholesterol results in increased expression of STAR protein]
27-hydroxycholesterol results in increased expression of STAR mRNA; 27-hydroxycholesterol results in increased expression of STAR protein
STAR protein results in increased abundance of 27-hydroxycholesterol
27-hydroxycholesterol promotes the reaction [NR5A1 protein results in increased expression of STAR protein]		 CTD PMID:9804848 PMID:12368294 PMID:15863358 PMID:20083572 PMID:23362264 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation
multiple interactions		 ISO 27-hydroxycholesterol results in increased phosphorylation of STAT3 protein
Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]; IL6 protein affects the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]
Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]; STAT3 protein promotes the reaction [27-hydroxycholesterol results in increased expression of VEGFA mRNA]; STAT3 protein promotes the reaction [27-hydroxycholesterol results in increased secretion of VEGFA protein]		 CTD PMID:27856279 PMID:28739487 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233 		JBrowse link
G Tff1 trefoil factor 1 increases expression
multiple interactions		 ISO 27-hydroxycholesterol results in increased expression of TFF1 mRNA
27-hydroxycholesterol promotes the reaction [ESR1 protein binds to TFF1 promoter]; fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased expression of TFF1 mRNA]		 CTD PMID:17872378 PMID:27856279 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [TGFB1 protein results in increased expression of CYP27A1 protein] which results in increased abundance of 27-hydroxycholesterol CTD PMID:15708352 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions
increases expression		 ISO [24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of TLR4 mRNA; Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of TLR4 mRNA]; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of TLR4 mRNA]; Quercetin inhibits the reaction [27-hydroxycholesterol results in increased expression of TLR4 mRNA]; Quercetin inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of TLR4 mRNA] CTD PMID:24802026 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression ISO 27-hydroxycholesterol results in increased expression of VCAM1 mRNA CTD PMID:19426978 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619 		JBrowse link
G Vegfa vascular endothelial growth factor A increases secretion
multiple interactions
increases expression		 ISO 27-hydroxycholesterol results in increased secretion of VEGFA protein
Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased expression of VEGFA mRNA]; Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased secretion of VEGFA protein]; STAT3 protein promotes the reaction [27-hydroxycholesterol results in increased expression of VEGFA mRNA]; STAT3 protein promotes the reaction [27-hydroxycholesterol results in increased secretion of VEGFA protein]		 CTD PMID:27856279 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    chemical entity 19761
      molecular entity 19759
        polyatomic entity 19677
          heteroatomic molecular entity 19607
            hydroxides 19071
              organic hydroxy compound 18657
                hydroxy steroid 12645
                  26-hydroxy steroid 54
                    (24S,25S)-cholest-5-en-3beta,24,26-triol 0
                    (24S,26)-dihydroxycholesterol 0
                    (24Z),26-hydroxydesmosterol 0
                    (25R)-11alpha,20,26-trihydroxyecdysone 0
                    (25R)-26-hydroxycholestanol 0
                    (25R)-3beta,26-dihydroxycholest-5-en-7-one 0
                    (25R)-4beta,26-dihydroxycholesterol 0
                    (25R)-7alpha,26-dihydroxycholest-4-en-3-one 0
                    (25S)-11alpha,20,26-trihydroxyecdysone 0
                    20,26-dihydroxyecdysone 0
                    26-hydroxybrassinolide 0
                    26-hydroxycastasterone 0
                    26-hydroxycholest-4-en-3-one + 0
                    26-hydroxycholesterol + 54
                    5beta-cholestane-3alpha,7alpha,12alpha,24,26-pentol + 0
                    5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + 0
                    5beta-cholestane-3alpha,7alpha,24,26-tetrol + 0
                    5beta-cholestane-3alpha,7alpha,26-triol 0
                    5beta-cyprinol + 0
                    5beta-cyprinol sulfate 0
                    5beta-scymnol + 0
                    7alpha,12alpha,26-trihydroxy-5beta-cholestan-3-one 0
                    7alpha,12alpha,26-trihydroxycholest-4-en-3-one 0
                    7alpha,26-dihydroxy-5beta-cholestan-3-one 0
                    7alpha,26-dihydroxycholest-4-en-3-one 0
                    7alpha,26-dihydroxycholesterol + 0
                    barogenin 0
                    inokosterone 0
                    makisterone B 0
                    podecdysone B 0
                    polypodine B 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            organic molecule 19493
                              organic cyclic compound 19318
                                organic polycyclic compound 16513
                                  steroid 13047
                                    hydroxy steroid 12645
                                      26-hydroxy steroid 54
                                        (24S,25S)-cholest-5-en-3beta,24,26-triol 0
                                        (24S,26)-dihydroxycholesterol 0
                                        (24Z),26-hydroxydesmosterol 0
                                        (25R)-11alpha,20,26-trihydroxyecdysone 0
                                        (25R)-26-hydroxycholestanol 0
                                        (25R)-3beta,26-dihydroxycholest-5-en-7-one 0
                                        (25R)-4beta,26-dihydroxycholesterol 0
                                        (25R)-7alpha,26-dihydroxycholest-4-en-3-one 0
                                        (25S)-11alpha,20,26-trihydroxyecdysone 0
                                        20,26-dihydroxyecdysone 0
                                        26-hydroxybrassinolide 0
                                        26-hydroxycastasterone 0
                                        26-hydroxycholest-4-en-3-one + 0
                                        26-hydroxycholesterol + 54
                                        5beta-cholestane-3alpha,7alpha,12alpha,24,26-pentol + 0
                                        5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + 0
                                        5beta-cholestane-3alpha,7alpha,24,26-tetrol + 0
                                        5beta-cholestane-3alpha,7alpha,26-triol 0
                                        5beta-cyprinol + 0
                                        5beta-cyprinol sulfate 0
                                        5beta-scymnol + 0
                                        7alpha,12alpha,26-trihydroxy-5beta-cholestan-3-one 0
                                        7alpha,12alpha,26-trihydroxycholest-4-en-3-one 0
                                        7alpha,26-dihydroxy-5beta-cholestan-3-one 0
                                        7alpha,26-dihydroxycholest-4-en-3-one 0
                                        7alpha,26-dihydroxycholesterol + 0
                                        barogenin 0
                                        inokosterone 0
                                        makisterone B 0
                                        podecdysone B 0
                                        polypodine B 0
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