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G |
Abca1 |
ATP binding cassette subfamily A member 1 |
multiple interactions increases expression |
ISO EXP |
Docosahexaenoic Acids inhibits the reaction [27-hydroxycholesterol results in increased expression of ABCA1 mRNA]; Linoleic Acid inhibits the reaction [27-hydroxycholesterol results in increased expression of ABCA1 mRNA]; Oleic Acid inhibits the reaction [27-hydroxycholesterol results in increased expression of ABCA1 mRNA] 27-hydroxycholesterol results in increased expression of ABCA1 mRNA; 27-hydroxycholesterol results in increased expression of ABCA1 protein [Fingolimod Hydrochloride results in increased abundance of 27-hydroxycholesterol] which results in increased expression of ABCA1 mRNA |
CTD |
PMID:15148325 PMID:17088262 PMID:18356535 PMID:18841091 PMID:20056921 PMID:28167099 |
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NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
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G |
Abcg1 |
ATP binding cassette subfamily G member 1 |
increases expression |
ISO |
27-hydroxycholesterol results in increased expression of ABCG1 protein |
CTD |
PMID:17088262 |
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NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489
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G |
Apoa1 |
apolipoprotein A1 |
multiple interactions |
ISO |
27-hydroxycholesterol promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]; 27-hydroxycholesterol promotes the reaction [STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]] |
CTD |
PMID:20083572 |
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NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
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G |
Apoe |
apolipoprotein E |
increases expression |
EXP |
27-hydroxycholesterol results in increased expression of APOE mRNA; 27-hydroxycholesterol results in increased expression of APOE protein |
CTD |
PMID:28167099 |
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NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
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G |
App |
amyloid beta precursor protein |
multiple interactions decreases secretion increases expression |
ISO |
27-hydroxycholesterol results in decreased metabolism of and results in decreased secretion of APP protein 27-hydroxycholesterol results in decreased secretion of APP protein alternative form 27-hydroxycholesterol results in increased expression of APP protein alternative form |
CTD |
PMID:15148325 PMID:19126211 PMID:19158428 |
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NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
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G |
Arc |
activity-regulated cytoskeleton-associated protein |
decreases expression |
EXP |
27-hydroxycholesterol results in decreased expression of ARC protein |
CTD |
PMID:18503570 |
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NCBI chr 7:115,907,097...115,911,059
Ensembl chr 7:115,907,097...115,910,541
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G |
Bace1 |
beta-secretase 1 |
increases expression |
ISO |
27-hydroxycholesterol results in increased expression of BACE1 protein |
CTD |
PMID:19126211 |
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NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions increases expression |
ISO |
[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CCL2 mRNA; Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of CCL2 mRNA]; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CCL2 mRNA] |
CTD |
PMID:24802026 |
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NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
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G |
Ccl3 |
C-C motif chemokine ligand 3 |
increases expression increases secretion |
ISO |
27-hydroxycholesterol results in increased expression of CCL3 mRNA 27-hydroxycholesterol results in increased secretion of CCL3 protein |
CTD |
PMID:24370436 |
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NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
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G |
Ccl4 |
C-C motif chemokine ligand 4 |
increases secretion increases expression |
ISO |
27-hydroxycholesterol results in increased secretion of CCL4 protein 27-hydroxycholesterol results in increased expression of CCL4 mRNA |
CTD |
PMID:24370436 |
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NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
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G |
Ccn5 |
cellular communication network factor 5 |
multiple interactions increases expression |
ISO |
Fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased expression of CCN5 mRNA] |
CTD |
PMID:17872378 |
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NCBI chr 3:160,207,969...160,219,316
Ensembl chr 3:160,207,913...160,219,331
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G |
Cd36 |
CD36 molecule |
increases expression multiple interactions |
ISO |
27-hydroxycholesterol results in increased expression of CD36 mRNA [24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CD36 mRNA; Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of CD36 mRNA]; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CD36 mRNA]; Quercetin inhibits the reaction [27-hydroxycholesterol results in increased expression of CD36 mRNA]; Quercetin inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CD36 mRNA] |
CTD |
PMID:24802026 |
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NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
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G |
Ces1d |
carboxylesterase 1D |
decreases activity multiple interactions |
ISO |
27-hydroxycholesterol results in decreased activity of CES1 protein 27-hydroxycholesterol inhibits the reaction [CES1 protein results in increased metabolism of bioresmethrin] |
CTD |
PMID:19761868 |
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NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
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G |
Cxcl12 |
C-X-C motif chemokine ligand 12 |
increases expression multiple interactions |
ISO |
27-hydroxycholesterol results in increased expression of CXCL12 mRNA fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased expression of CXCL12 mRNA] |
CTD |
PMID:17872378 |
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NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
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G |
Cyp27a1 |
cytochrome P450, family 27, subfamily a, polypeptide 1 |
increases abundance multiple interactions increases chemical synthesis |
ISO EXP |
CYP27A1 protein results in increased abundance of 27-hydroxycholesterol [CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol CYP27A1 protein results in increased chemical synthesis of 27-hydroxycholesterol [[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol] which results in increased activity of HMGCR protein; [CYP27A1 protein results in increased hydroxylation of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol; [CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol; [CYP27A1 protein results in increased oxidation of 27-hydroxycholesterol] which results in increased chemical synthesis of 3-hydroxy-5-cholestenoic acid; [TGFB1 protein results in increased expression of CYP27A1 protein] which results in increased abundance of 27-hydroxycholesterol |
CTD |
PMID:8496670 PMID:9215552 PMID:9660774 PMID:11408283 PMID:11714861 PMID:12119285 PMID:12531903 PMID:14622972 PMID:15708352 |
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NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169
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G |
Cyp7a1 |
cytochrome P450 family 7 subfamily A member 1 |
increases metabolic processing |
ISO EXP |
CYP7A1 protein results in increased metabolism of 27-hydroxycholesterol |
CTD |
PMID:10882719 |
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NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
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G |
Cyp7b1 |
cytochrome P450 family 7 subfamily B member 1 |
increases hydroxylation increases metabolic processing increases abundance |
ISO |
CYP7B1 protein results in increased hydroxylation of 27-hydroxycholesterol CYP7B1 protein results in increased metabolism of 27-hydroxycholesterol CYP7B1 gene mutant form results in increased abundance of 27-hydroxycholesterol |
CTD |
PMID:10588945 PMID:10748047 |
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NCBI chr 2:102,701,903...102,871,257
Ensembl chr 2:102,701,903...102,871,257
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G |
E2f1 |
E2F transcription factor 1 |
increases expression |
ISO |
27-hydroxycholesterol results in increased expression of E2F1 mRNA |
CTD |
PMID:17872378 |
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NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
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G |
Erbb4 |
erb-b2 receptor tyrosine kinase 4 |
decreases expression |
ISO |
27-hydroxycholesterol results in decreased expression of ERBB4 mRNA |
CTD |
PMID:17872378 |
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NCBI chr 9:75,021,790...76,178,936
Ensembl chr 9:75,021,790...75,528,644
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions affects response to substance increases degradation |
ISO |
27-hydroxycholesterol binds to and affects the folding of and results in increased activity of ESR1 protein; 27-hydroxycholesterol binds to and results in decreased activity of ESR1 protein; 27-hydroxycholesterol inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein]; 27-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; 27-hydroxycholesterol promotes the reaction [ESR1 protein binds to TFF1 promoter]; fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased activity of ESR1 protein] ESR1 protein affects the susceptibility to 27-hydroxycholesterol ESR1 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS2 mRNA]; ESR1 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS3 mRNA] 27-hydroxycholesterol results in increased degradation of ESR1 protein |
CTD |
PMID:17872378 PMID:17873880 |
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NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
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G |
Esr2 |
estrogen receptor 2 |
multiple interactions affects response to substance |
ISO |
27-hydroxycholesterol binds to and affects the folding of and results in increased activity of ESR2 protein; 27-hydroxycholesterol binds to and results in decreased activity of ESR2 protein; 27-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR2 protein] ESR2 protein affects the susceptibility to 27-hydroxycholesterol ESR2 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS2 mRNA]; ESR2 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS3 mRNA] |
CTD |
PMID:17872378 PMID:17873880 |
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NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
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G |
Grin1 |
glutamate ionotropic receptor NMDA type subunit 1 |
decreases expression |
EXP |
27-hydroxycholesterol results in decreased expression of GRIN1 protein |
CTD |
PMID:18503570 |
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NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
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G |
Grin2a |
glutamate ionotropic receptor NMDA type subunit 2A |
decreases phosphorylation |
EXP |
27-hydroxycholesterol results in decreased phosphorylation of GRIN2A protein |
CTD |
PMID:18503570 |
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NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
increases expression |
ISO |
27-hydroxycholesterol results in increased expression of HIF1A protein |
CTD |
PMID:27856279 |
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NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
decreases activity decreases expression multiple interactions |
ISO EXP |
27-hydroxycholesterol metabolite results in decreased activity of HMGCR protein; 27-hydroxycholesterol results in decreased activity of HMGCR protein 27-hydroxycholesterol results in decreased expression of HMGCR mRNA; 27-hydroxycholesterol results in decreased expression of HMGCR protein [[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol] which results in increased activity of HMGCR protein; Dehydroepiandrosterone inhibits the reaction [27-hydroxycholesterol results in decreased activity of HMGCR protein]; Pregnenolone inhibits the reaction [27-hydroxycholesterol results in decreased activity of HMGCR protein] |
CTD |
PMID:7749852 PMID:7751816 PMID:7788503 PMID:9059514 PMID:11408283 PMID:18024962 PMID:28167099 |
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NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
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G |
Icam1 |
intercellular adhesion molecule 1 |
increases expression |
ISO |
27-hydroxycholesterol results in increased expression of ICAM1 mRNA |
CTD |
PMID:19426978 |
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NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
27-hydroxycholesterol promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] |
CTD |
PMID:11851725 |
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NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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G |
Il6 |
interleukin 6 |
increases secretion increases expression multiple interactions |
ISO |
27-hydroxycholesterol results in increased secretion of IL6 protein 27-hydroxycholesterol results in increased expression of IL6 mRNA Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased expression of IL6 mRNA]; Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased secretion of IL6 protein]; IL6 protein affects the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [27-hydroxycholesterol results in increased expression of IL6 mRNA]; stattic inhibits the reaction [27-hydroxycholesterol results in increased secretion of IL6 protein] |
CTD |
PMID:11851725 PMID:28739487 |
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NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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G |
Itgb1 |
integrin subunit beta 1 |
multiple interactions increases expression |
ISO |
[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA; Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of ITGB1 mRNA]; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA]; Quercetin inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA] |
CTD |
PMID:24802026 |
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NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
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G |
Lcat |
lecithin cholesterol acyltransferase |
increases metabolic processing |
ISO |
LCAT protein results in increased metabolism of 27-hydroxycholesterol |
CTD |
PMID:7744831 |
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NCBI chr19:37,913,333...37,916,799
Ensembl chr19:37,913,336...37,916,813
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G |
Ldlr |
low density lipoprotein receptor |
decreases activity decreases expression |
ISO EXP |
27-hydroxycholesterol results in decreased activity of LDLR protein 27-hydroxycholesterol results in decreased expression of LDLR mRNA; 27-hydroxycholesterol results in decreased expression of LDLR protein |
CTD |
PMID:8820113 PMID:28167099 |
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NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
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G |
Lipe |
lipase E, hormone sensitive type |
multiple interactions |
ISO |
LIPE protein promotes the reaction [27-hydroxycholesterol results in increased expression of STAR mRNA]; LIPE protein promotes the reaction [27-hydroxycholesterol results in increased expression of STAR protein] |
CTD |
PMID:23362264 |
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NCBI chr 1:82,248,031...82,266,727
Ensembl chr 1:82,248,046...82,266,727
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G |
Mmp9 |
matrix metallopeptidase 9 |
increases expression multiple interactions |
ISO |
27-hydroxycholesterol results in increased expression of MMP9 mRNA Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of MMP9 mRNA] |
CTD |
PMID:24802026 |
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NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions decreases expression |
ISO |
27-hydroxycholesterol inhibits the reaction [Estradiol results in increased expression of NOS2 mRNA]; ESR1 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS2 mRNA]; ESR2 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS2 mRNA] |
CTD |
PMID:17873880 |
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NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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G |
Nos3 |
nitric oxide synthase 3 |
decreases expression multiple interactions |
ISO |
27-hydroxycholesterol results in decreased expression of NOS3 mRNA 27-hydroxycholesterol inhibits the reaction [Estradiol results in increased expression of NOS3 mRNA]; ESR1 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS3 mRNA]; ESR2 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS3 mRNA] |
CTD |
PMID:17873880 |
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NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
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G |
Npc1 |
NPC intracellular cholesterol transporter 1 |
affects abundance |
ISO |
NPC1 protein affects the abundance of 27-hydroxycholesterol |
CTD |
PMID:18483620 |
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NCBI chr18:3,616,878...3,662,656
Ensembl chr18:3,616,878...3,662,683
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G |
Nr1h3 |
nuclear receptor subfamily 1, group H, member 3 |
increases expression |
EXP |
27-hydroxycholesterol results in increased expression of NR1H3 mRNA; 27-hydroxycholesterol results in increased expression of NR1H3 protein |
CTD |
PMID:28167099 |
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NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750
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G |
Nr5a1 |
nuclear receptor subfamily 5, group A, member 1 |
increases activity multiple interactions |
ISO |
27-hydroxycholesterol results in increased activity of NR5A1 protein 27-hydroxycholesterol promotes the reaction [NR5A1 protein results in increased expression of STAR protein] |
CTD |
PMID:9144161 PMID:9804848 |
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NCBI chr 3:22,998,900...23,020,441
Ensembl chr 3:22,999,616...23,020,441
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G |
Pgr |
progesterone receptor |
increases expression multiple interactions |
ISO |
27-hydroxycholesterol results in increased expression of PGR mRNA; 27-hydroxycholesterol results in increased expression of PGR protein fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased expression of PGR mRNA] |
CTD |
PMID:17872378 |
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NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
increases expression |
EXP |
27-hydroxycholesterol results in increased expression of PPARG mRNA; 27-hydroxycholesterol results in increased expression of PPARG protein |
CTD |
PMID:28167099 |
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NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
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G |
Ptges |
prostaglandin E synthase |
increases expression multiple interactions |
ISO |
27-hydroxycholesterol results in increased expression of PTGES mRNA Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of PTGES mRNA]; Quercetin inhibits the reaction [27-hydroxycholesterol results in increased expression of PTGES mRNA] |
CTD |
PMID:24802026 |
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NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
increases expression multiple interactions |
ISO |
27-hydroxycholesterol results in increased expression of PTGS2 protein [24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of PTGS2 protein |
CTD |
PMID:24802026 |
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NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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G |
Sele |
selectin E |
increases expression |
ISO |
27-hydroxycholesterol results in increased expression of SELE mRNA |
CTD |
PMID:19426978 |
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NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
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G |
Smpd2 |
sphingomyelin phosphodiesterase 2 |
decreases activity |
ISO |
27-hydroxycholesterol results in decreased activity of SMPD2 protein |
CTD |
PMID:15261762 |
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NCBI chr20:46,212,070...46,215,183
Ensembl chr20:46,211,892...46,215,120
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G |
Snca |
synuclein alpha |
increases expression |
ISO |
27-hydroxycholesterol results in increased expression of SNCA mRNA; 27-hydroxycholesterol results in increased expression of SNCA protein |
CTD |
PMID:18841091 PMID:19014385 |
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NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
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G |
Src |
SRC proto-oncogene, non-receptor tyrosine kinase |
decreases activity |
EXP |
27-hydroxycholesterol results in decreased activity of SRC protein |
CTD |
PMID:18503570 |
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NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
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G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
decreases expression |
EXP |
27-hydroxycholesterol results in decreased expression of SREBF1 mRNA; 27-hydroxycholesterol results in decreased expression of SREBF1 protein |
CTD |
PMID:28167099 |
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NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
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G |
Star |
steroidogenic acute regulatory protein |
multiple interactions increases abundance increases expression |
ISO EXP |
27-hydroxycholesterol promotes the reaction [NR5A1 protein results in increased expression of STAR protein] STAR protein results in increased abundance of 27-hydroxycholesterol 27-hydroxycholesterol promotes the reaction [STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]]; LIPE protein promotes the reaction [27-hydroxycholesterol results in increased expression of STAR mRNA]; LIPE protein promotes the reaction [27-hydroxycholesterol results in increased expression of STAR protein] 27-hydroxycholesterol results in increased expression of STAR mRNA; 27-hydroxycholesterol results in increased expression of STAR protein |
CTD |
PMID:9804848 PMID:12368294 PMID:15863358 PMID:20083572 PMID:23362264 |
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NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions increases phosphorylation |
ISO |
Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]; STAT3 protein promotes the reaction [27-hydroxycholesterol results in increased expression of VEGFA mRNA]; STAT3 protein promotes the reaction [27-hydroxycholesterol results in increased secretion of VEGFA protein] Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]; IL6 protein affects the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein] |
CTD |
PMID:27856279 PMID:28739487 |
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NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
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G |
Tff1 |
trefoil factor 1 |
multiple interactions increases expression |
ISO |
27-hydroxycholesterol promotes the reaction [ESR1 protein binds to TFF1 promoter]; fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased expression of TFF1 mRNA] |
CTD |
PMID:17872378 PMID:27856279 |
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NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
[TGFB1 protein results in increased expression of CYP27A1 protein] which results in increased abundance of 27-hydroxycholesterol |
CTD |
PMID:15708352 |
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NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
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G |
Tlr4 |
toll-like receptor 4 |
increases expression multiple interactions |
ISO |
27-hydroxycholesterol results in increased expression of TLR4 mRNA [24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of TLR4 mRNA; Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of TLR4 mRNA]; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of TLR4 mRNA]; Quercetin inhibits the reaction [27-hydroxycholesterol results in increased expression of TLR4 mRNA]; Quercetin inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of TLR4 mRNA] |
CTD |
PMID:24802026 |
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NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
increases expression |
ISO |
27-hydroxycholesterol results in increased expression of VCAM1 mRNA |
CTD |
PMID:19426978 |
|
NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions increases secretion increases expression |
ISO |
Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased expression of VEGFA mRNA]; Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased secretion of VEGFA protein]; STAT3 protein promotes the reaction [27-hydroxycholesterol results in increased expression of VEGFA mRNA]; STAT3 protein promotes the reaction [27-hydroxycholesterol results in increased secretion of VEGFA protein] |
CTD |
PMID:27856279 |
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NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
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G |
Abca1 |
ATP binding cassette subfamily A member 1 |
increases expression multiple interactions |
ISO EXP |
27-hydroxycholesterol results in increased expression of ABCA1 mRNA; 27-hydroxycholesterol results in increased expression of ABCA1 protein [Fingolimod Hydrochloride results in increased abundance of 27-hydroxycholesterol] which results in increased expression of ABCA1 mRNA Docosahexaenoic Acids inhibits the reaction [27-hydroxycholesterol results in increased expression of ABCA1 mRNA]; Linoleic Acid inhibits the reaction [27-hydroxycholesterol results in increased expression of ABCA1 mRNA]; Oleic Acid inhibits the reaction [27-hydroxycholesterol results in increased expression of ABCA1 mRNA] |
CTD |
PMID:15148325 PMID:17088262 PMID:18356535 PMID:18841091 PMID:20056921 PMID:28167099 |
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NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
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G |
Abcg1 |
ATP binding cassette subfamily G member 1 |
increases expression |
ISO |
27-hydroxycholesterol results in increased expression of ABCG1 protein |
CTD |
PMID:17088262 |
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NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489
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G |
Apoa1 |
apolipoprotein A1 |
multiple interactions |
ISO |
27-hydroxycholesterol promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]; 27-hydroxycholesterol promotes the reaction [STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]] |
CTD |
PMID:20083572 |
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NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
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G |
Apoe |
apolipoprotein E |
increases expression |
EXP |
27-hydroxycholesterol results in increased expression of APOE mRNA; 27-hydroxycholesterol results in increased expression of APOE protein |
CTD |
PMID:28167099 |
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NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
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G |
App |
amyloid beta precursor protein |
multiple interactions increases expression decreases secretion |
ISO |
27-hydroxycholesterol results in decreased metabolism of and results in decreased secretion of APP protein 27-hydroxycholesterol results in increased expression of APP protein alternative form 27-hydroxycholesterol results in decreased secretion of APP protein alternative form |
CTD |
PMID:15148325 PMID:19126211 PMID:19158428 |
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NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
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G |
Arc |
activity-regulated cytoskeleton-associated protein |
decreases expression |
EXP |
27-hydroxycholesterol results in decreased expression of ARC protein |
CTD |
PMID:18503570 |
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NCBI chr 7:115,907,097...115,911,059
Ensembl chr 7:115,907,097...115,910,541
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G |
Bace1 |
beta-secretase 1 |
increases expression |
ISO |
27-hydroxycholesterol results in increased expression of BACE1 protein |
CTD |
PMID:19126211 |
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NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
increases expression multiple interactions |
ISO |
27-hydroxycholesterol results in increased expression of CCL2 mRNA [24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CCL2 mRNA; Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of CCL2 mRNA]; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CCL2 mRNA] |
CTD |
PMID:24802026 |
|
NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
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G |
Ccl3 |
C-C motif chemokine ligand 3 |
increases expression increases secretion |
ISO |
27-hydroxycholesterol results in increased expression of CCL3 mRNA 27-hydroxycholesterol results in increased secretion of CCL3 protein |
CTD |
PMID:24370436 |
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NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
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G |
Ccl4 |
C-C motif chemokine ligand 4 |
increases secretion increases expression |
ISO |
27-hydroxycholesterol results in increased secretion of CCL4 protein 27-hydroxycholesterol results in increased expression of CCL4 mRNA |
CTD |
PMID:24370436 |
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NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
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G |
Ccn5 |
cellular communication network factor 5 |
increases expression multiple interactions |
ISO |
27-hydroxycholesterol results in increased expression of CCN5 mRNA Fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased expression of CCN5 mRNA] |
CTD |
PMID:17872378 |
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NCBI chr 3:160,207,969...160,219,316
Ensembl chr 3:160,207,913...160,219,331
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G |
Cd36 |
CD36 molecule |
multiple interactions increases expression |
ISO |
[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CD36 mRNA; Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of CD36 mRNA]; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CD36 mRNA]; Quercetin inhibits the reaction [27-hydroxycholesterol results in increased expression of CD36 mRNA]; Quercetin inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CD36 mRNA] |
CTD |
PMID:24802026 |
|
NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
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G |
Ces1d |
carboxylesterase 1D |
multiple interactions decreases activity |
ISO |
27-hydroxycholesterol inhibits the reaction [CES1 protein results in increased metabolism of bioresmethrin] 27-hydroxycholesterol results in decreased activity of CES1 protein |
CTD |
PMID:19761868 |
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NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
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G |
Cxcl12 |
C-X-C motif chemokine ligand 12 |
increases expression multiple interactions |
ISO |
27-hydroxycholesterol results in increased expression of CXCL12 mRNA fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased expression of CXCL12 mRNA] |
CTD |
PMID:17872378 |
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NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
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G |
Cyp27a1 |
cytochrome P450, family 27, subfamily a, polypeptide 1 |
increases abundance increases chemical synthesis multiple interactions |
ISO EXP |
CYP27A1 protein results in increased abundance of 27-hydroxycholesterol CYP27A1 protein results in increased chemical synthesis of 27-hydroxycholesterol [[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol] which results in increased activity of HMGCR protein; [CYP27A1 protein results in increased hydroxylation of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol; [CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol; [CYP27A1 protein results in increased oxidation of 27-hydroxycholesterol] which results in increased chemical synthesis of 3-hydroxy-5-cholestenoic acid; [TGFB1 protein results in increased expression of CYP27A1 protein] which results in increased abundance of 27-hydroxycholesterol |
CTD |
PMID:8496670 PMID:9215552 PMID:9660774 PMID:11408283 PMID:11714861 PMID:12119285 PMID:12531903 PMID:14622972 PMID:15708352 |
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NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169
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G |
Cyp7a1 |
cytochrome P450 family 7 subfamily A member 1 |
increases metabolic processing |
ISO EXP |
CYP7A1 protein results in increased metabolism of 27-hydroxycholesterol |
CTD |
PMID:10882719 |
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NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
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G |
Cyp7b1 |
cytochrome P450 family 7 subfamily B member 1 |
increases abundance increases metabolic processing increases hydroxylation |
ISO |
CYP7B1 gene mutant form results in increased abundance of 27-hydroxycholesterol CYP7B1 protein results in increased metabolism of 27-hydroxycholesterol CYP7B1 protein results in increased hydroxylation of 27-hydroxycholesterol |
CTD |
PMID:10588945 PMID:10748047 |
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NCBI chr 2:102,701,903...102,871,257
Ensembl chr 2:102,701,903...102,871,257
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G |
E2f1 |
E2F transcription factor 1 |
increases expression |
ISO |
27-hydroxycholesterol results in increased expression of E2F1 mRNA |
CTD |
PMID:17872378 |
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NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
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G |
Erbb4 |
erb-b2 receptor tyrosine kinase 4 |
decreases expression |
ISO |
27-hydroxycholesterol results in decreased expression of ERBB4 mRNA |
CTD |
PMID:17872378 |
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NCBI chr 9:75,021,790...76,178,936
Ensembl chr 9:75,021,790...75,528,644
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions affects response to substance increases degradation |
ISO |
27-hydroxycholesterol binds to and affects the folding of and results in increased activity of ESR1 protein; 27-hydroxycholesterol binds to and results in decreased activity of ESR1 protein; 27-hydroxycholesterol inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein]; 27-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; 27-hydroxycholesterol promotes the reaction [ESR1 protein binds to TFF1 promoter]; fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased activity of ESR1 protein] ESR1 protein affects the susceptibility to 27-hydroxycholesterol ESR1 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS2 mRNA]; ESR1 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS3 mRNA] 27-hydroxycholesterol results in increased degradation of ESR1 protein |
CTD |
PMID:17872378 PMID:17873880 |
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NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
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G |
Esr2 |
estrogen receptor 2 |
multiple interactions affects response to substance |
ISO |
27-hydroxycholesterol binds to and affects the folding of and results in increased activity of ESR2 protein; 27-hydroxycholesterol binds to and results in decreased activity of ESR2 protein; 27-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR2 protein] ESR2 protein affects the susceptibility to 27-hydroxycholesterol ESR2 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS2 mRNA]; ESR2 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS3 mRNA] |
CTD |
PMID:17872378 PMID:17873880 |
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NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
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G |
Grin1 |
glutamate ionotropic receptor NMDA type subunit 1 |
decreases expression |
EXP |
27-hydroxycholesterol results in decreased expression of GRIN1 protein |
CTD |
PMID:18503570 |
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NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
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G |
Grin2a |
glutamate ionotropic receptor NMDA type subunit 2A |
decreases phosphorylation |
EXP |
27-hydroxycholesterol results in decreased phosphorylation of GRIN2A protein |
CTD |
PMID:18503570 |
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NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
increases expression |
ISO |
27-hydroxycholesterol results in increased expression of HIF1A protein |
CTD |
PMID:27856279 |
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NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
multiple interactions decreases expression decreases activity |
ISO EXP |
[[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol] which results in increased activity of HMGCR protein; Dehydroepiandrosterone inhibits the reaction [27-hydroxycholesterol results in decreased activity of HMGCR protein]; Pregnenolone inhibits the reaction [27-hydroxycholesterol results in decreased activity of HMGCR protein] 27-hydroxycholesterol results in decreased expression of HMGCR mRNA; 27-hydroxycholesterol results in decreased expression of HMGCR protein 27-hydroxycholesterol metabolite results in decreased activity of HMGCR protein; 27-hydroxycholesterol results in decreased activity of HMGCR protein |
CTD |
PMID:7749852 PMID:7751816 PMID:7788503 PMID:9059514 PMID:11408283 PMID:18024962 PMID:28167099 |
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NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
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G |
Icam1 |
intercellular adhesion molecule 1 |
increases expression |
ISO |
27-hydroxycholesterol results in increased expression of ICAM1 mRNA |
CTD |
PMID:19426978 |
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NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
27-hydroxycholesterol promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] |
CTD |
PMID:11851725 |
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NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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G |
Il6 |
interleukin 6 |
increases secretion multiple interactions increases expression |
ISO |
27-hydroxycholesterol results in increased secretion of IL6 protein Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased expression of IL6 mRNA]; Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased secretion of IL6 protein]; IL6 protein affects the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [27-hydroxycholesterol results in increased expression of IL6 mRNA]; stattic inhibits the reaction [27-hydroxycholesterol results in increased secretion of IL6 protein] |
CTD |
PMID:11851725 PMID:28739487 |
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NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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G |
Itgb1 |
integrin subunit beta 1 |
multiple interactions increases expression |
ISO |
[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA; Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of ITGB1 mRNA]; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA]; Quercetin inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA] |
CTD |
PMID:24802026 |
|
NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
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G |
Lcat |
lecithin cholesterol acyltransferase |
increases metabolic processing |
ISO |
LCAT protein results in increased metabolism of 27-hydroxycholesterol |
CTD |
PMID:7744831 |
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NCBI chr19:37,913,333...37,916,799
Ensembl chr19:37,913,336...37,916,813
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G |
Ldlr |
low density lipoprotein receptor |
decreases activity decreases expression |
ISO EXP |
27-hydroxycholesterol results in decreased activity of LDLR protein 27-hydroxycholesterol results in decreased expression of LDLR mRNA; 27-hydroxycholesterol results in decreased expression of LDLR protein |
CTD |
PMID:8820113 PMID:28167099 |
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NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
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G |
Lipe |
lipase E, hormone sensitive type |
multiple interactions |
ISO |
LIPE protein promotes the reaction [27-hydroxycholesterol results in increased expression of STAR mRNA]; LIPE protein promotes the reaction [27-hydroxycholesterol results in increased expression of STAR protein] |
CTD |
PMID:23362264 |
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NCBI chr 1:82,248,031...82,266,727
Ensembl chr 1:82,248,046...82,266,727
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions increases expression |
ISO |
Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of MMP9 mRNA] |
CTD |
PMID:24802026 |
|
NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions decreases expression |
ISO |
27-hydroxycholesterol inhibits the reaction [Estradiol results in increased expression of NOS2 mRNA]; ESR1 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS2 mRNA]; ESR2 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS2 mRNA] |
CTD |
PMID:17873880 |
|
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions decreases expression |
ISO |
27-hydroxycholesterol inhibits the reaction [Estradiol results in increased expression of NOS3 mRNA]; ESR1 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS3 mRNA]; ESR2 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS3 mRNA] |
CTD |
PMID:17873880 |
|
NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
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G |
Npc1 |
NPC intracellular cholesterol transporter 1 |
affects abundance |
ISO |
NPC1 protein affects the abundance of 27-hydroxycholesterol |
CTD |
PMID:18483620 |
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NCBI chr18:3,616,878...3,662,656
Ensembl chr18:3,616,878...3,662,683
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G |
Nr1h3 |
nuclear receptor subfamily 1, group H, member 3 |
increases expression |
EXP |
27-hydroxycholesterol results in increased expression of NR1H3 mRNA; 27-hydroxycholesterol results in increased expression of NR1H3 protein |
CTD |
PMID:28167099 |
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NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750
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G |
Nr5a1 |
nuclear receptor subfamily 5, group A, member 1 |
increases activity multiple interactions |
ISO |
27-hydroxycholesterol results in increased activity of NR5A1 protein 27-hydroxycholesterol promotes the reaction [NR5A1 protein results in increased expression of STAR protein] |
CTD |
PMID:9144161 PMID:9804848 |
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NCBI chr 3:22,998,900...23,020,441
Ensembl chr 3:22,999,616...23,020,441
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G |
Pgr |
progesterone receptor |
increases expression multiple interactions |
ISO |
27-hydroxycholesterol results in increased expression of PGR mRNA; 27-hydroxycholesterol results in increased expression of PGR protein fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased expression of PGR mRNA] |
CTD |
PMID:17872378 |
|
NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
increases expression |
EXP |
27-hydroxycholesterol results in increased expression of PPARG mRNA; 27-hydroxycholesterol results in increased expression of PPARG protein |
CTD |
PMID:28167099 |
|
NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
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G |
Ptges |
prostaglandin E synthase |
increases expression multiple interactions |
ISO |
27-hydroxycholesterol results in increased expression of PTGES mRNA Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of PTGES mRNA]; Quercetin inhibits the reaction [27-hydroxycholesterol results in increased expression of PTGES mRNA] |
CTD |
PMID:24802026 |
|
NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
increases expression multiple interactions |
ISO |
27-hydroxycholesterol results in increased expression of PTGS2 protein [24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of PTGS2 protein |
CTD |
PMID:24802026 |
|
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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G |
Sele |
selectin E |
increases expression |
ISO |
27-hydroxycholesterol results in increased expression of SELE mRNA |
CTD |
PMID:19426978 |
|
NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
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G |
Smpd2 |
sphingomyelin phosphodiesterase 2 |
decreases activity |
ISO |
27-hydroxycholesterol results in decreased activity of SMPD2 protein |
CTD |
PMID:15261762 |
|
NCBI chr20:46,212,070...46,215,183
Ensembl chr20:46,211,892...46,215,120
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G |
Snca |
synuclein alpha |
increases expression |
ISO |
27-hydroxycholesterol results in increased expression of SNCA mRNA; 27-hydroxycholesterol results in increased expression of SNCA protein |
CTD |
PMID:18841091 PMID:19014385 |
|
NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
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G |
Src |
SRC proto-oncogene, non-receptor tyrosine kinase |
decreases activity |
EXP |
27-hydroxycholesterol results in decreased activity of SRC protein |
CTD |
PMID:18503570 |
|
NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
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G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
decreases expression |
EXP |
27-hydroxycholesterol results in decreased expression of SREBF1 mRNA; 27-hydroxycholesterol results in decreased expression of SREBF1 protein |
CTD |
PMID:28167099 |
|
NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
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G |
Star |
steroidogenic acute regulatory protein |
multiple interactions increases expression increases abundance |
ISO EXP |
27-hydroxycholesterol promotes the reaction [STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]]; LIPE protein promotes the reaction [27-hydroxycholesterol results in increased expression of STAR mRNA]; LIPE protein promotes the reaction [27-hydroxycholesterol results in increased expression of STAR protein] 27-hydroxycholesterol results in increased expression of STAR mRNA; 27-hydroxycholesterol results in increased expression of STAR protein STAR protein results in increased abundance of 27-hydroxycholesterol 27-hydroxycholesterol promotes the reaction [NR5A1 protein results in increased expression of STAR protein] |
CTD |
PMID:9804848 PMID:12368294 PMID:15863358 PMID:20083572 PMID:23362264 |
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NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
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G |
Stat3 |
signal transducer and activator of transcription 3 |
increases phosphorylation multiple interactions |
ISO |
27-hydroxycholesterol results in increased phosphorylation of STAT3 protein Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]; IL6 protein affects the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein] Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]; STAT3 protein promotes the reaction [27-hydroxycholesterol results in increased expression of VEGFA mRNA]; STAT3 protein promotes the reaction [27-hydroxycholesterol results in increased secretion of VEGFA protein] |
CTD |
PMID:27856279 PMID:28739487 |
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NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
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G |
Tff1 |
trefoil factor 1 |
increases expression multiple interactions |
ISO |
27-hydroxycholesterol results in increased expression of TFF1 mRNA 27-hydroxycholesterol promotes the reaction [ESR1 protein binds to TFF1 promoter]; fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased expression of TFF1 mRNA] |
CTD |
PMID:17872378 PMID:27856279 |
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NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
[TGFB1 protein results in increased expression of CYP27A1 protein] which results in increased abundance of 27-hydroxycholesterol |
CTD |
PMID:15708352 |
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NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
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G |
Tlr4 |
toll-like receptor 4 |
multiple interactions increases expression |
ISO |
[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of TLR4 mRNA; Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of TLR4 mRNA]; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of TLR4 mRNA]; Quercetin inhibits the reaction [27-hydroxycholesterol results in increased expression of TLR4 mRNA]; Quercetin inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of TLR4 mRNA] |
CTD |
PMID:24802026 |
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NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
increases expression |
ISO |
27-hydroxycholesterol results in increased expression of VCAM1 mRNA |
CTD |
PMID:19426978 |
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NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
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G |
Vegfa |
vascular endothelial growth factor A |
increases secretion multiple interactions increases expression |
ISO |
27-hydroxycholesterol results in increased secretion of VEGFA protein Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased expression of VEGFA mRNA]; Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased secretion of VEGFA protein]; STAT3 protein promotes the reaction [27-hydroxycholesterol results in increased expression of VEGFA mRNA]; STAT3 protein promotes the reaction [27-hydroxycholesterol results in increased secretion of VEGFA protein] |
CTD |
PMID:27856279 |
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NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
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