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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:6alpha-hydroxy steroid
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Accession:CHEBI:36850 term browser browse the term
Synonyms:related_synonym: 6alpha-hydroxy steroids

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ginsenoside F1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il6 interleukin 6 multiple interactions ISO ginsenoside F1 inhibits the reaction [Galactose results in increased secretion of IL6 protein] CTD PMID:29412148 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO ginsenoside F1 inhibits the reaction [Galactose affects the localization of RELA protein] CTD PMID:29412148 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
hyodeoxycholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases secretion ISO AHR gene mutant form results in increased secretion of hyodeoxycholic acid CTD PMID:32679164 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions EXP [CYP2D6 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of hyodeoxycholic acid CTD PMID:18039809 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Lithocholic Acid] which results in increased abundance of hyodeoxycholic acid CTD PMID:19487251 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 increases abundance ISO HSD11B1 gene mutant form results in increased abundance of hyodeoxycholic acid CTD PMID:25061560 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation
affects metabolic processing
increases glycosylation		 ISO UGT2B7 protein alternative form results in increased glucuronidation of hyodeoxycholic acid; UGT2B7 protein results in increased glucuronidation of hyodeoxycholic acid
UGT2B7 protein affects the metabolism of hyodeoxycholic acid
UGT2B7 protein results in increased glycosylation of hyodeoxycholic acid		 CTD PMID:8423545 PMID:8517101 PMID:12527334 PMID:21415305 NCBI chr14:22,597,103...22,619,968 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    chemical entity 19853
      molecular entity 19851
        polyatomic entity 19765
          heteroatomic molecular entity 19692
            hydroxides 19123
              organic hydroxy compound 18678
                hydroxy steroid 12397
                  6-hydroxy steroid 21
                    6alpha-hydroxy steroid 7
                      5alpha-androstane-3beta,6alpha,17beta-triol 0
                      6alpha,20xi-murideoxycholic acid + 5
                      6alpha-hydroxy-17beta-estradiol 0
                      6alpha-hydroxy-6-deoxocastasterone 0
                      6alpha-hydroxycholestanol 0
                      6alpha-hydroxyestrone 0
                      ginsenoside F1 2
                      hyocholic acid + 0
                      physalin G 0
                      protopanaxatriol 0
                      taurohyocholic acid 0
                      withalongolide K 0
                      withalongolide L 0
                      yuccalan 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19744
                    p-block element atom 19744
                      carbon group element atom 19650
                        carbon atom 19639
                          organic molecular entity 19639
                            organic molecule 19568
                              organic cyclic compound 19378
                                organic polycyclic compound 16409
                                  steroid 12816
                                    hydroxy steroid 12397
                                      6-hydroxy steroid 21
                                        6alpha-hydroxy steroid 7
                                          5alpha-androstane-3beta,6alpha,17beta-triol 0
                                          6alpha,20xi-murideoxycholic acid + 5
                                          6alpha-hydroxy-17beta-estradiol 0
                                          6alpha-hydroxy-6-deoxocastasterone 0
                                          6alpha-hydroxycholestanol 0
                                          6alpha-hydroxyestrone 0
                                          ginsenoside F1 2
                                          hyocholic acid + 0
                                          physalin G 0
                                          protopanaxatriol 0
                                          taurohyocholic acid 0
                                          withalongolide K 0
                                          withalongolide L 0
                                          yuccalan 0
paths to the root