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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:5-hydroxy steroid
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Accession:CHEBI:36848 term browser browse the term
Synonyms:related_synonym: 5-hydroxy steroids



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dihydroouabain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G G6pc glucose-6-phosphatase, catalytic increases expression
multiple interactions
ISO dihydroouabain results in increased expression of G6PC1 mRNA
dihydroouabain promotes the reaction [RORC protein binds to G6PC1 promoter]
CTD PMID:29981919 NCBI chr11:101,258,542...101,268,729
Ensembl chr11:101,258,387...101,268,729
JBrowse link
G Il17a interleukin 17A multiple interactions ISO dihydroouabain results in increased expression of and results in increased secretion of IL17A protein CTD PMID:29981919 NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720
JBrowse link
G Il17f interleukin 17F multiple interactions ISO dihydroouabain results in increased expression of and results in increased secretion of IL17F protein CTD PMID:29981919 NCBI chr 1:20,847,370...20,855,498
Ensembl chr 1:20,847,370...20,860,841
JBrowse link
G Npas2 neuronal PAS domain protein 2 multiple interactions
increases expression
ISO dihydroouabain promotes the reaction [RORC protein binds to NPAS2 promoter]
dihydroouabain results in increased expression of NPAS2 mRNA
CTD PMID:29981919 NCBI chr 1:39,233,013...39,402,321
Ensembl chr 1:39,232,812...39,402,317
JBrowse link
G Rorc RAR-related orphan receptor gamma increases expression
multiple interactions
ISO dihydroouabain results in increased expression of RORC mRNA
dihydroouabain promotes the reaction [RORC protein binds to G6PC1 promoter]; dihydroouabain promotes the reaction [RORC protein binds to NPAS2 promoter]; RORC protein promotes the reaction [dihydroouabain results in increased expression of RORC mRNA]
CTD PMID:29981919 NCBI chr 3:94,280,101...94,305,583
Ensembl chr 3:94,280,101...94,305,583
JBrowse link
hellebrigenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO hellebrigenin results in decreased phosphorylation of and results in decreased expression of AKT1 protein CTD PMID:24954031 NCBI chr12:112,620,255...112,641,318
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Atm ataxia telangiectasia mutated increases phosphorylation ISO hellebrigenin results in increased phosphorylation of ATM protein CTD PMID:24954031 NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040
JBrowse link
G Bax BCL2-associated X protein affects localization ISO hellebrigenin affects the localization of BAX protein CTD PMID:24954031 NCBI chr 7:45,111,119...45,116,344
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Ccnb1 cyclin B1 increases expression ISO hellebrigenin results in increased expression of CCNB1 protein CTD PMID:24954031 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078
JBrowse link
G Cdc25c cell division cycle 25C decreases phosphorylation ISO hellebrigenin results in decreased phosphorylation of CDC25C protein CTD PMID:24954031 NCBI chr18:34,866,046...34,884,644
Ensembl chr18:34,866,046...34,884,586
JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases phosphorylation ISO hellebrigenin results in increased phosphorylation of CDK1 protein CTD PMID:24954031 NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768
JBrowse link
G Chek2 checkpoint kinase 2 increases phosphorylation ISO hellebrigenin results in increased phosphorylation of CHEK2 protein CTD PMID:24954031 NCBI chr 5:110,987,668...111,022,006
Ensembl chr 5:110,987,845...111,022,011
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases activity ISO hellebrigenin results in increased activity of PARP1 protein CTD PMID:24954031 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
ouabain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin affects expression ISO Ouabain affects the expression of A2M protein CTD PMID:17268060 NCBI chr 6:121,612,920...121,656,197
Ensembl chr 6:121,612,335...121,656,186
JBrowse link
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A multiple interactions
increases expression
ISO 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain results in increased expression of ABCB1 protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain results in increased expression of ABCB1 mRNA]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain results in increased expression of ABCB1 protein]; [Ouabain results in increased expression of ABCB1] which results in decreased susceptibility to Doxorubicin; KN 93 inhibits the reaction [Ouabain results in increased expression of ABCB1 protein]
Ouabain results in increased expression of ABCB1 mRNA; Ouabain results in increased expression of ABCB1 protein
CTD PMID:19647009 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
JBrowse link
G Acaa2 acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) affects expression ISO Ouabain affects the expression of ACAA2 protein CTD PMID:17268060 NCBI chr18:74,912,283...74,939,278
Ensembl chr18:74,912,268...74,939,279
JBrowse link
G Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 affects expression ISO Ouabain affects the expression of ACE mRNA; Ouabain affects the expression of ACE protein CTD PMID:16565308 NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790
JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta affects expression ISO Ouabain affects the expression of ACTA2 protein CTD PMID:17268060 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990
JBrowse link
G Adh1 alcohol dehydrogenase 1 (class I) affects expression ISO Ouabain affects the expression of ADH1C protein CTD PMID:17268060 NCBI chr 3:137,983,346...137,996,459
Ensembl chr 3:137,966,752...137,996,459
JBrowse link
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) affects expression
increases expression
ISO Ouabain affects the expression of AGT protein
Ouabain results in increased expression of AGT protein
CTD PMID:11768735 PMID:16565308 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445
JBrowse link
G Agtr1a angiotensin II receptor, type 1a affects expression
decreases expression
ISO Ouabain affects the expression of AGTR1A mRNA
Ouabain results in decreased expression of AGTR1A protein
CTD PMID:16565308 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850
JBrowse link
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 increases expression ISO Ouabain results in increased expression of AIFM1 protein CTD PMID:31436044 NCBI chr  X:47,563,821...47,602,440
Ensembl chr  X:47,563,821...47,602,440
JBrowse link
G Anxa1 annexin A1 affects expression ISO Ouabain affects the expression of ANXA1 protein CTD PMID:17268060 NCBI chr19:20,350,798...20,368,035
Ensembl chr19:20,350,792...20,368,308
JBrowse link
G Anxa2 annexin A2 affects expression ISO Ouabain affects the expression of ANXA2 protein CTD PMID:17268060 NCBI chr 9:69,360,965...69,399,074
Ensembl chr 9:69,360,902...69,399,077
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO Ouabain results in increased expression of APAF1 protein CTD PMID:31436044 NCBI chr10:90,825,173...90,918,688
Ensembl chr10:90,825,173...90,918,632
JBrowse link
G Araf Araf proto-oncogene, serine/threonine kinase decreases expression ISO Ouabain results in decreased expression of ARAF mRNA CTD PMID:16412265 NCBI chr  X:20,663,946...20,726,760
Ensembl chr  X:20,664,053...20,726,758
JBrowse link
G Arih1 ariadne RBR E3 ubiquitin protein ligase 1 decreases expression ISO Ouabain results in decreased expression of ARIH1 mRNA CTD PMID:16412265 NCBI chr 9:59,295,837...59,395,469
Ensembl chr 9:59,295,541...59,393,901
JBrowse link
G Arpc5 actin related protein 2/3 complex, subunit 5 affects expression ISO Ouabain affects the expression of ARPC5 protein CTD PMID:17268060 NCBI chr 1:152,642,293...152,651,331
Ensembl chr 1:152,642,293...152,651,348
JBrowse link
G Arrb1 arrestin, beta 1 increases expression ISO Ouabain results in increased expression of ARRB1 mRNA CTD PMID:16412265 NCBI chr 7:99,184,356...99,255,979
Ensembl chr 7:99,184,673...99,255,978
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 affects expression ISO Ouabain affects the expression of ASAH1 protein CTD PMID:17268060 NCBI chr 8:41,793,683...41,850,681
Ensembl chr 8:41,793,234...41,827,810
JBrowse link
G Atf6b activating transcription factor 6 beta increases expression ISO Ouabain results in increased expression of ATF6B protein CTD PMID:31436044 NCBI chr17:34,866,120...34,874,048
Ensembl chr17:34,866,120...34,874,048
JBrowse link
G Atm ataxia telangiectasia mutated increases phosphorylation ISO Ouabain results in increased phosphorylation of ATM protein CTD PMID:31436044 NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040
JBrowse link
G Atp12a ATPase, H+/K+ transporting, nongastric, alpha polypeptide multiple interactions ISO Ouabain inhibits the reaction [[ATP12A protein co-treated with ATP4B protein] results in increased uptake of Rubidium] CTD PMID:8853415 NCBI chr14:56,602,525...56,626,008
Ensembl chr14:56,602,525...56,626,007
JBrowse link
G Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide multiple interactions
increases expression
affects expression
affects binding
ISO Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A1 mRNA]; Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A1 protein]
Ouabain affects the expression of ATP1A1 protein
Ouabain results in increased expression of ATP1A1 mRNA; Ouabain results in increased expression of ATP1A1 protein
Ouabain binds to ATP1A1 protein
CTD PMID:11768735 PMID:11834625 PMID:12479229 PMID:16716361 PMID:19995221 NCBI chr 3:101,483,535...101,512,023
Ensembl chr 3:101,483,535...101,512,000
JBrowse link
G Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide multiple interactions
increases expression
decreases expression
affects expression
decreases activity
affects response to substance
affects binding
ISO
EXP
Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A2 mRNA]
Ouabain results in increased expression of ATP1A2 protein
Ouabain results in decreased expression of ATP1A2 mRNA
Ouabain affects the expression of ATP1A2 protein
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in decreased expression of ATP1A2 mRNA]
Ouabain results in decreased activity of ATP1A2 protein
Ouabain binds to and results in decreased activity of ATP1A2 protein
ATP1A2 protein affects the susceptibility to Ouabain
Ouabain binds to ATP1A2 protein
CTD PMID:11834625 PMID:12479229 PMID:15458945 PMID:16166162 PMID:16716361 More... NCBI chr 1:172,099,276...172,125,631
Ensembl chr 1:172,099,276...172,125,631
JBrowse link
G Atp1a3 ATPase, Na+/K+ transporting, alpha 3 polypeptide increases expression
multiple interactions
decreases expression
affects expression
affects binding
ISO Ouabain results in increased expression of ATP1A3 mRNA; Ouabain results in increased expression of ATP1A3 protein
Potassium Chloride inhibits the reaction [ATP1A3 protein binds to Ouabain]
Ouabain results in decreased expression of ATP1A3 mRNA
Ouabain affects the expression of ATP1A3 protein
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in decreased expression of ATP1A3 mRNA]
ATP1A3 protein binds to Ouabain; Ouabain binds to ATP1A3 protein
CTD PMID:11204457 PMID:12479229 PMID:15276875 PMID:19687166 PMID:19995221 More... NCBI chr 7:24,677,592...24,705,502
Ensembl chr 7:24,677,592...24,705,383
JBrowse link
G Atp1b1 ATPase, Na+/K+ transporting, beta 1 polypeptide multiple interactions
increases expression
ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Ouabain results in increased expression of ATP1B1 mRNA]; Calcium affects the reaction [Ouabain results in increased expression of ATP1B1 mRNA]; W 7 inhibits the reaction [Ouabain results in increased expression of ATP1B1 mRNA] CTD PMID:11204457 NCBI chr 1:164,264,668...164,285,924
Ensembl chr 1:164,264,678...164,285,924
JBrowse link
G Atp4b ATPase, H+/K+ exchanging, beta polypeptide multiple interactions ISO Ouabain inhibits the reaction [[ATP12A protein co-treated with ATP4B protein] results in increased uptake of Rubidium] CTD PMID:8853415 NCBI chr 8:13,436,209...13,446,778
Ensembl chr 8:13,436,205...13,446,825
JBrowse link
G Atp5a1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1 affects expression ISO Ouabain affects the expression of ATP5F1A protein CTD PMID:17268060 NCBI chr18:77,861,468...77,870,569
Ensembl chr18:77,861,429...77,870,569
JBrowse link
G Atr ataxia telangiectasia and Rad3 related decreases phosphorylation ISO Ouabain results in decreased phosphorylation of ATR protein CTD PMID:31436044 NCBI chr 9:95,739,650...95,834,813
Ensembl chr 9:95,739,650...95,833,834
JBrowse link
G Bahd1 bromo adjacent homology domain containing 1 decreases expression ISO Ouabain results in decreased expression of BAHD1 mRNA CTD PMID:16412265 NCBI chr 2:118,730,817...118,755,009
Ensembl chr 2:118,730,858...118,755,009
JBrowse link
G Bax BCL2-associated X protein affects localization
increases expression
multiple interactions
ISO Ouabain affects the localization of BAX protein
Ouabain results in increased expression of BAX protein
Ouabain inhibits the reaction [HSPD1 protein binds to BAX protein]
CTD PMID:17096883 PMID:18247327 PMID:31436044 NCBI chr 7:45,111,119...45,116,344
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO Ouabain results in decreased expression of BCL2 protein CTD PMID:31436044 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bcl2l1 BCL2-like 1 decreases expression ISO Ouabain results in decreased expression of BCL2L1 protein CTD PMID:31436044 NCBI chr 2:152,600,652...152,675,723
Ensembl chr 2:152,622,588...152,673,648
JBrowse link
G Bdnf brain derived neurotrophic factor multiple interactions
decreases expression
ISO Lithium inhibits the reaction [Ouabain results in decreased expression of BDNF protein] CTD PMID:19954800 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352
JBrowse link
G Brca1 breast cancer 1, early onset decreases expression ISO Ouabain results in decreased expression of BRCA1 protein CTD PMID:31436044 NCBI chr11:101,379,587...101,442,808
Ensembl chr11:101,379,590...101,442,781
JBrowse link
G Calb1 calbindin 1 decreases expression ISO Ouabain results in decreased expression of CALB1 protein CTD PMID:20105455 NCBI chr 4:15,881,264...15,906,709
Ensembl chr 4:15,881,264...15,908,064
JBrowse link
G Calm4 calmodulin 4 affects expression ISO Ouabain affects the expression of CALML5 protein CTD PMID:17268060 NCBI chr13:3,887,757...3,888,671
Ensembl chr13:3,887,757...3,888,673
JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II, beta increases expression ISO Ouabain results in increased expression of CAMK2B protein CTD PMID:31436044 NCBI chr11:5,919,642...6,016,401
Ensembl chr11:5,919,644...6,016,362
JBrowse link
G Canx calnexin increases expression ISO Ouabain results in increased expression of CANX protein CTD PMID:18247327 NCBI chr11:50,184,784...50,216,500
Ensembl chr11:50,184,788...50,216,500
JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
increases activity
ISO Ouabain results in increased expression of CASP3 protein
Ouabain results in increased activity of and results in increased cleavage of CASP3 protein
Ouabain results in increased activity of CASP3 protein
CTD PMID:11435898 PMID:17096883 PMID:18247327 PMID:20435043 PMID:31436044 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp4 caspase 4, apoptosis-related cysteine peptidase increases expression ISO Ouabain results in increased expression of CASP4 protein CTD PMID:31436044 NCBI chr 9:5,308,816...5,336,791
Ensembl chr 9:5,308,828...5,336,783
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Ouabain results in increased expression of and results in increased activity of CASP8 protein CTD PMID:31436044 NCBI chr 1:58,834,398...58,886,662
Ensembl chr 1:58,834,533...58,886,662
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Ouabain results in increased expression of and results in increased activity of CASP9 protein CTD PMID:31436044 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Cat catalase multiple interactions
decreases activity
ISO Lithium inhibits the reaction [Ouabain results in decreased activity of CAT protein]; Valproic Acid inhibits the reaction [Ouabain results in decreased activity of CAT protein] CTD PMID:20627318 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Cav1 caveolin 1, caveolae protein decreases expression ISO Ouabain results in decreased expression of CAV1 mRNA CTD PMID:28795476 NCBI chr 6:17,306,287...17,341,327
Ensembl chr 6:17,306,334...17,341,451
JBrowse link
G Ccdc14 coiled-coil domain containing 14 decreases expression ISO Ouabain results in decreased expression of CCDC14 mRNA CTD PMID:16412265 NCBI chr16:34,510,940...34,545,574
Ensembl chr16:34,510,986...34,545,572
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 multiple interactions
increases expression
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Ouabain results in increased expression of CCL2 mRNA]; Amiloride inhibits the reaction [Ouabain results in increased expression of CCL2 protein]; Sodium deficiency inhibits the reaction [Ouabain results in increased expression of CCL2 mRNA]; Sodium deficiency inhibits the reaction [Ouabain results in increased expression of CCL2 protein]
Ouabain results in increased expression of CCL2 mRNA; Ouabain results in increased expression of CCL2 protein
CTD PMID:11340305 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Ccna1 cyclin A1 decreases expression ISO Ouabain results in decreased expression of CCNA1 mRNA CTD PMID:20460749 NCBI chr 3:54,952,890...54,965,055
Ensembl chr 3:54,952,890...54,962,922
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Ouabain results in decreased expression of CCNA2 mRNA CTD PMID:21215801 NCBI chr 3:36,619,014...36,627,187
Ensembl chr 3:36,619,014...36,626,299
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Ouabain results in decreased expression of CCND1 mRNA CTD PMID:28795476 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Cdh1 cadherin 1 decreases expression
increases expression
ISO Ouabain results in decreased expression of CDH1 protein
Ouabain results in increased expression of CDH1 mRNA
CTD PMID:28795476 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878
JBrowse link
G Cdh2 cadherin 2 decreases expression ISO Ouabain results in decreased expression of CDH2 mRNA; Ouabain results in decreased expression of CDH2 protein CTD PMID:28795476 NCBI chr18:16,721,934...16,942,303
Ensembl chr18:16,721,934...16,942,303
JBrowse link
G Cdk2 cyclin-dependent kinase 2 decreases expression ISO Ouabain results in decreased expression of CDK2 mRNA; Ouabain results in decreased expression of CDK2 protein CTD PMID:20460749 PMID:21215801 PMID:31436044 NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO Ouabain results in decreased expression of CDK6 protein CTD PMID:31436044 NCBI chr 5:3,391,004...3,581,008
Ensembl chr 5:3,391,485...3,581,008
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) decreases expression
increases expression
ISO Ouabain results in decreased expression of CDKN1A mRNA; Ouabain results in decreased expression of CDKN1A protein
Ouabain results in increased expression of CDKN1A mRNA; Ouabain results in increased expression of CDKN1A protein
CTD PMID:20460749 PMID:21215801 PMID:28795476 PMID:31436044 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G Ckb creatine kinase, brain decreases activity ISO Ouabain results in decreased activity of CKB protein CTD PMID:19911114 NCBI chr12:111,635,789...111,638,772
Ensembl chr12:111,635,795...111,638,772
JBrowse link
G Cldn1 claudin 1 decreases expression ISO Ouabain results in decreased expression of CLDN1 protein CTD PMID:18247327 NCBI chr16:26,175,395...26,190,589
Ensembl chr16:26,175,392...26,190,591
JBrowse link
G Cnpy2 canopy FGF signaling regulator 2 affects expression ISO Ouabain affects the expression of CNPY2 protein CTD PMID:17268060 NCBI chr10:128,157,972...128,163,056
Ensembl chr10:128,158,328...128,163,422
JBrowse link
G Col1a1 collagen, type I, alpha 1 multiple interactions
increases expression
ISO MIR29B1 mRNA inhibits the reaction [Ouabain results in increased expression of COL1A1 mRNA] CTD PMID:26702050 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868
JBrowse link
G Cs citrate synthase decreases activity ISO Ouabain results in decreased activity of CS protein CTD PMID:20372980 NCBI chr10:128,173,596...128,198,351
Ensembl chr10:128,173,603...128,198,348
JBrowse link
G Cyc1 cytochrome c-1 multiple interactions ISO Ouabain results in decreased expression of and affects the localization of CYC1 protein CTD PMID:18247327 NCBI chr15:76,227,711...76,230,460
Ensembl chr15:76,227,723...76,230,460
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Ouabain results in increased expression of DDIT3 protein CTD PMID:31436044 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157
JBrowse link
G Ddost dolichyl-di-phosphooligosaccharide-protein glycotransferase decreases expression ISO Ouabain results in decreased expression of DDOST mRNA CTD PMID:16412265 NCBI chr 4:138,032,049...138,039,930
Ensembl chr 4:138,032,041...138,039,939
JBrowse link
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 increases expression ISO Ouabain results in increased expression of DNAJA3 mRNA CTD PMID:28795476 NCBI chr16:4,501,934...4,525,559
Ensembl chr16:4,457,853...4,525,559
JBrowse link
G Drd1 dopamine receptor D1 multiple interactions
decreases expression
ISO Ouabain results in decreased expression of and results in increased phosphorylation of DRD1 protein
Ouabain results in increased phosphorylation of and results in decreased expression of DRD1 protein
Ouabain results in decreased expression of DRD1 mRNA
CTD PMID:19626329 PMID:20132239 NCBI chr13:54,205,202...54,209,677
Ensembl chr13:54,205,202...54,209,724
JBrowse link
G Dsg1a desmoglein 1 alpha affects expression ISO Ouabain affects the expression of DSG1 protein CTD PMID:17268060 NCBI chr18:20,443,930...20,476,410
Ensembl chr18:20,443,868...20,476,407
JBrowse link
G Dut deoxyuridine triphosphatase affects expression ISO Ouabain affects the expression of DUT protein CTD PMID:17268060 NCBI chr 2:125,089,168...125,100,969
Ensembl chr 2:125,089,110...125,100,528
JBrowse link
G Ece1 endothelin converting enzyme 1 increases expression ISO Ouabain results in increased expression of ECE1 protein CTD PMID:18247327 NCBI chr 4:137,589,548...137,692,540
Ensembl chr 4:137,589,548...137,692,540
JBrowse link
G Echs1 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial affects expression ISO Ouabain affects the expression of ECHS1 protein CTD PMID:17268060 NCBI chr 7:139,685,623...139,696,334
Ensembl chr 7:139,685,623...139,696,389
JBrowse link
G Edn1 endothelin 1 increases expression
decreases expression
ISO Ouabain results in increased expression of EDN1 mRNA
Ouabain results in decreased expression of EDN1 mRNA
CTD PMID:15477225 PMID:28795476 NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466
JBrowse link
G Ednra endothelin receptor type A increases expression ISO Ouabain results in increased expression of EDNRA mRNA; Ouabain results in increased expression of EDNRA protein CTD PMID:15477225 PMID:16982439 NCBI chr 8:78,389,658...78,451,081
Ensembl chr 8:78,389,660...78,451,093
JBrowse link
G Egfr epidermal growth factor receptor decreases phosphorylation ISO Ouabain results in decreased phosphorylation of EGFR protein CTD PMID:28795476 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases expression ISO Ouabain results in increased expression of EIF2A protein CTD PMID:31436044 NCBI chr 3:58,433,242...58,464,922
Ensembl chr 3:58,433,242...58,464,922
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO Ouabain results in increased expression of and results in increased phosphorylation of EIF2AK3 protein CTD PMID:31436044 NCBI chr 6:70,821,468...70,882,225
Ensembl chr 6:70,821,499...70,882,229
JBrowse link
G Eif3k eukaryotic translation initiation factor 3, subunit K affects expression ISO Ouabain affects the expression of EIF3K protein CTD PMID:17268060 NCBI chr 7:28,670,797...28,681,322
Ensembl chr 7:28,670,797...28,681,289
JBrowse link
G Endog endonuclease G increases expression ISO Ouabain results in increased expression of ENDOG protein CTD PMID:31436044 NCBI chr 2:30,061,421...30,064,081
Ensembl chr 2:30,061,505...30,064,081
JBrowse link
G Ercc4 excision repair cross-complementing rodent repair deficiency, complementation group 4 decreases expression ISO Ouabain results in decreased expression of ERCC4 mRNA CTD PMID:24124520 NCBI chr16:12,927,230...12,969,873
Ensembl chr16:12,927,548...12,968,481
JBrowse link
G Ets1 E26 avian leukemia oncogene 1, 5' domain decreases expression ISO Ouabain results in decreased expression of ETS1 mRNA CTD PMID:28795476 NCBI chr 9:32,547,501...32,669,116
Ensembl chr 9:32,547,517...32,669,116
JBrowse link
G Fadd Fas (TNFRSF6)-associated via death domain increases expression ISO Ouabain results in increased expression of FADD protein CTD PMID:31436044 NCBI chr 7:144,132,060...144,136,178
Ensembl chr 7:144,131,055...144,136,200
JBrowse link
G Fancd2 Fanconi anemia, complementation group D2 multiple interactions
decreases expression
ISO Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]; SB 203580 inhibits the reaction [Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]]
Ouabain results in decreased expression of FANCD2 mRNA
CTD PMID:24124520 NCBI chr 6:113,508,622...113,573,981
Ensembl chr 6:113,508,643...113,573,978
JBrowse link
G Fancf Fanconi anemia, complementation group F decreases expression ISO Ouabain results in decreased expression of FANCF mRNA CTD PMID:24124520 NCBI chr 7:51,510,325...51,512,015
Ensembl chr 7:51,510,325...51,512,015
JBrowse link
G Fanci Fanconi anemia, complementation group I decreases expression
multiple interactions
ISO Ouabain results in decreased expression of FANCI mRNA
Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein]
CTD PMID:24124520 NCBI chr 7:79,042,056...79,100,013
Ensembl chr 7:79,041,677...79,100,012
JBrowse link
G Fars2 phenylalanine-tRNA synthetase 2 (mitochondrial) increases expression ISO Ouabain results in increased expression of FARS2 mRNA CTD PMID:16412265 NCBI chr13:36,301,373...36,721,569
Ensembl chr13:36,301,395...36,910,254
JBrowse link
G Fas Fas (TNF receptor superfamily member 6) increases expression ISO Ouabain results in increased expression of FAS protein CTD PMID:31436044 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172
JBrowse link
G Fasl Fas ligand (TNF superfamily, member 6) increases expression ISO Ouabain results in increased expression of FASLG protein CTD PMID:31436044 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064
JBrowse link
G Fbxo32 F-box protein 32 multiple interactions EXP Ouabain affects the reaction [Botulinum Toxins, Type A affects the expression of FBXO32 mRNA] CTD PMID:21139329 NCBI chr15:58,039,275...58,078,288
Ensembl chr15:58,039,275...58,078,328
JBrowse link
G Fh1 fumarate hydratase 1 affects expression ISO Ouabain affects the expression of FH protein CTD PMID:17268060 NCBI chr 1:175,428,944...175,453,201
Ensembl chr 1:175,427,940...175,453,201
JBrowse link
G Fkbp7 FK506 binding protein 7 increases expression ISO Ouabain results in increased expression of FKBP7 mRNA CTD PMID:16412265 NCBI chr 2:76,493,378...76,503,442
Ensembl chr 2:76,493,388...76,503,460
JBrowse link
G Fn1 fibronectin 1 decreases expression ISO Ouabain results in decreased expression of FN1 mRNA CTD PMID:28795476 NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359
JBrowse link
G Gc vitamin D binding protein affects expression ISO Ouabain affects the expression of GC protein CTD PMID:17268060 NCBI chr 5:89,565,370...89,605,757
Ensembl chr 5:89,565,381...89,605,757
JBrowse link
G Glrb glycine receptor, beta subunit increases expression ISO Ouabain results in increased expression of GLRB mRNA CTD PMID:16412265 NCBI chr 3:80,750,905...80,820,994
Ensembl chr 3:80,750,906...80,820,967
JBrowse link
G Grb2 growth factor receptor bound protein 2 decreases expression ISO Ouabain results in decreased expression of GRB2 protein CTD PMID:28795476 NCBI chr11:115,534,871...115,599,423
Ensembl chr11:115,534,871...115,599,423
JBrowse link
G Gtpbp6 GTP binding protein 6 (putative) increases expression ISO Ouabain results in increased expression of GTPBP6 mRNA CTD PMID:16412265 NCBI chr 5:110,251,842...110,256,204
Ensembl chr 5:110,251,841...110,256,063
JBrowse link
G H2ax H2A.X variant histone increases phosphorylation ISO Ouabain results in increased phosphorylation of H2AX protein CTD PMID:31436044 NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374
JBrowse link
G Hey1 hairy/enhancer-of-split related with YRPW motif 1 increases expression ISO Ouabain results in increased expression of HEY1 mRNA CTD PMID:28795476 NCBI chr 3:8,728,419...8,732,098
Ensembl chr 3:8,728,419...8,732,316
JBrowse link
G Hgf hepatocyte growth factor multiple interactions ISO Ouabain inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide] CTD PMID:18031729 NCBI chr 5:16,758,493...16,827,448
Ensembl chr 5:16,758,493...16,825,150
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions
affects localization
increases activity
ISO 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain affects the localization of HIF1A protein]; 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain results in increased phosphorylation of HIF1A protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Ouabain affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Ouabain results in increased phosphorylation of HIF1A protein]; Ouabain results in increased phosphorylation of and results in increased expression of HIF1A protein
Ouabain results in increased activity of HIF1A protein
CTD PMID:19647009 NCBI chr12:73,948,098...73,994,328
Ensembl chr12:73,948,149...73,994,304
JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 affects expression ISO Ouabain affects the expression of HNRNPA2B1 protein CTD PMID:17268060 NCBI chr 6:51,437,414...51,448,054
Ensembl chr 6:51,437,912...51,446,874
JBrowse link
G Hnrnpdl heterogeneous nuclear ribonucleoprotein D-like decreases expression ISO Ouabain results in decreased expression of HNRNPDL mRNA CTD PMID:16412265 NCBI chr 5:100,181,436...100,187,769
Ensembl chr 5:100,181,436...100,187,523
JBrowse link
G Hpcal1 hippocalcin-like 1 affects expression ISO Ouabain affects the expression of HPCAL1 protein CTD PMID:17268060 NCBI chr12:17,740,793...17,841,943
Ensembl chr12:17,740,857...17,841,934
JBrowse link
G Hrg histidine-rich glycoprotein affects expression ISO Ouabain affects the expression of HRG protein CTD PMID:17268060 NCBI chr16:22,769,822...22,780,409
Ensembl chr16:22,769,822...22,780,406
JBrowse link
G Hspa5 heat shock protein 5 increases expression ISO Ouabain results in increased expression of HSPA5 protein CTD PMID:31436044 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559
JBrowse link
G Hspd1 heat shock protein 1 (chaperonin) affects expression
multiple interactions
ISO Ouabain affects the expression of HSPD1 protein
Ouabain inhibits the reaction [HSPD1 protein binds to BAX protein]; Ouabain results in decreased expression of and affects the localization of HSPD1 protein
CTD PMID:17268060 PMID:18247327 NCBI chr 1:55,116,992...55,127,402
Ensembl chr 1:55,116,994...55,127,402
JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression ISO Ouabain results in increased expression of ID2 mRNA CTD PMID:28795476 NCBI chr12:25,143,798...25,146,091
Ensembl chr12:25,143,798...25,147,139
JBrowse link
G Il2ra interleukin 2 receptor, alpha chain decreases expression ISO Ouabain results in decreased expression of IL2RA mRNA CTD PMID:7593202 NCBI chr 2:11,647,603...11,698,005
Ensembl chr 2:11,647,618...11,698,004
JBrowse link
G Il2rb interleukin 2 receptor, beta chain decreases expression ISO Ouabain results in decreased expression of IL2RB CTD PMID:7593202 NCBI chr15:78,363,456...78,396,569
Ensembl chr15:78,363,456...78,379,471
JBrowse link
G Il6 interleukin 6 increases secretion
increases expression
ISO Ouabain results in increased secretion of IL6 protein
Ouabain results in increased expression of IL6 mRNA
CTD PMID:33760381 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Il6ra interleukin 6 receptor, alpha increases expression ISO Ouabain results in increased expression of IL6R mRNA CTD PMID:33760381 NCBI chr 3:89,776,631...89,820,503
Ensembl chr 3:89,771,366...89,820,503
JBrowse link
G Ilk integrin linked kinase decreases expression ISO Ouabain results in decreased expression of ILK mRNA CTD PMID:28795476 NCBI chr 7:105,385,797...105,392,132
Ensembl chr 7:105,385,799...105,392,132
JBrowse link
G Itgav integrin alpha V decreases expression ISO Ouabain results in decreased expression of ITGAV mRNA CTD PMID:28795476 NCBI chr 2:83,551,625...83,637,261
Ensembl chr 2:83,554,741...83,637,260
JBrowse link
G Jun jun proto-oncogene decreases phosphorylation
decreases expression
ISO Ouabain results in decreased phosphorylation of JUN protein
Ouabain results in decreased expression of JUN mRNA
CTD PMID:28795476 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
JBrowse link
G Kcnd2 potassium voltage-gated channel, Shal-related family, member 2 increases expression ISO Ouabain results in increased expression of KCND2 mRNA CTD PMID:16412265 NCBI chr 6:21,212,101...21,729,804
Ensembl chr 6:21,215,502...21,729,804
JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases expression
decreases activity
multiple interactions
ISO Ouabain results in decreased expression of KCNH2 protein modified form
Ouabain results in decreased activity of KCNH2 protein
Ouabain inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
CTD PMID:19139152 PMID:21158687 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 decreases expression ISO Ouabain results in decreased expression of LEF1 mRNA CTD PMID:28795476 NCBI chr 3:130,903,946...131,018,006
Ensembl chr 3:130,904,120...131,018,005
JBrowse link
G Lgals1 lectin, galactose binding, soluble 1 affects expression
increases expression
ISO Ouabain affects the expression of LGALS1 protein
Ouabain results in increased expression of LGALS1 protein
CTD PMID:17268060 PMID:18247327 NCBI chr15:78,810,925...78,814,665
Ensembl chr15:78,810,925...78,814,665
JBrowse link
G Limk1 LIM-domain containing, protein kinase decreases expression ISO Ouabain results in decreased expression of LIMK1 mRNA CTD PMID:28795476 NCBI chr 5:134,684,893...134,718,713
Ensembl chr 5:134,684,893...134,717,452
JBrowse link
G Lss lanosterol synthase increases abundance ISO LSS protein results in increased abundance of Ouabain CTD PMID:21106941 NCBI chr10:76,367,303...76,392,973
Ensembl chr10:76,367,422...76,392,972
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 increases expression ISO Ouabain results in increased expression of MAP2K6 mRNA CTD PMID:28795476 NCBI chr11:110,289,928...110,416,348
Ensembl chr11:110,289,948...110,416,348
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation
ISO N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased phosphorylation of MAPK1 protein]
Ouabain results in decreased phosphorylation of MAPK1 protein
CTD PMID:19687166 PMID:28795476 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
decreases phosphorylation
increases phosphorylation
ISO N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased phosphorylation of MAPK3 protein]
Ouabain results in decreased phosphorylation of MAPK3 protein
CTD PMID:19687166 PMID:28795476 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mapk7 mitogen-activated protein kinase 7 multiple interactions ISO Ouabain inhibits the reaction [palytoxin results in increased phosphorylation of and results in increased activity of MAPK7 protein] CTD PMID:19716839 NCBI chr11:61,379,638...61,385,101
Ensembl chr11:61,379,638...61,385,232
JBrowse link
G Mdh2 malate dehydrogenase 2, NAD (mitochondrial) affects expression ISO Ouabain affects the expression of MDH2 protein CTD PMID:17268060 NCBI chr 5:135,807,503...135,819,240
Ensembl chr 5:135,807,334...135,819,252
JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 multiple interactions ISO Ouabain results in decreased expression of and results in decreased phosphorylation of MDM2 protein CTD PMID:31436044 NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases expression ISO Ouabain results in decreased expression of MGMT protein CTD PMID:31436044 NCBI chr 7:136,496,192...136,729,922
Ensembl chr 7:136,496,343...136,731,995
JBrowse link
G Mir29b-1 microRNA 29b-1 decreases expression
multiple interactions
ISO Ouabain results in decreased expression of MIR29B1 mRNA
MIR29B1 mRNA inhibits the reaction [Ouabain results in increased expression of COL1A1 mRNA]
CTD PMID:26702050 NCBI chr 6:31,039,958...31,040,028
Ensembl chr 6:31,039,958...31,040,028
JBrowse link
G Mmp13 matrix metallopeptidase 13 decreases expression ISO Ouabain results in decreased expression of MMP13 mRNA CTD PMID:28795476 NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
multiple interactions
ISO Ouabain results in decreased expression of MMP2 mRNA
Ouabain results in decreased expression of and results in decreased activity of MMP2 protein
CTD PMID:28795476 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO Ouabain results in decreased expression of MMP9 mRNA; Ouabain results in decreased expression of MMP9 protein CTD PMID:28795476 PMID:33760381 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770
JBrowse link
G Mras muscle and microspikes RAS decreases expression ISO Ouabain results in decreased expression of MRAS mRNA CTD PMID:28795476 NCBI chr 9:99,267,473...99,319,505
Ensembl chr 9:99,267,473...99,319,434
JBrowse link
G Mrtfa myocardin related transcription factor A decreases expression ISO Ouabain results in decreased expression of MRTFA mRNA CTD PMID:28795476 NCBI chr15:80,896,482...81,074,937
Ensembl chr15:80,896,482...81,074,958
JBrowse link
G Myc myelocytomatosis oncogene decreases expression
increases expression
ISO Ouabain results in decreased expression of MYC mRNA; Ouabain results in decreased expression of MYC protein
Ouabain results in increased expression of MYC protein
CTD PMID:9653513 PMID:21215801 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
JBrowse link
G Myl12a myosin, light chain 12A, regulatory, non-sarcomeric increases expression ISO Ouabain results in increased expression of MYL12A protein CTD PMID:17268060 NCBI chr17:71,300,788...71,309,528
Ensembl chr17:71,300,651...71,309,873
JBrowse link
G Mylk myosin, light polypeptide kinase decreases expression ISO Ouabain results in decreased expression of MYLK mRNA CTD PMID:28795476 NCBI chr16:34,565,569...34,822,806
Ensembl chr16:34,565,580...34,822,790
JBrowse link
G Nectin3 nectin cell adhesion molecule 3 decreases expression ISO Ouabain results in decreased expression of NECTIN3 mRNA CTD PMID:28795476 NCBI chr16:46,208,028...46,318,898
Ensembl chr16:46,208,069...46,318,888
JBrowse link
G Nectin4 nectin cell adhesion molecule 4 increases expression ISO Ouabain results in increased expression of NECTIN4 mRNA CTD PMID:28795476 NCBI chr 1:171,197,741...171,215,855
Ensembl chr 1:171,197,667...171,216,166
JBrowse link
G Nefl neurofilament, light polypeptide decreases expression ISO Ouabain results in decreased expression of NEFL mRNA CTD PMID:28795476 NCBI chr14:68,321,312...68,326,544
Ensembl chr14:68,321,312...68,326,544
JBrowse link
G Nos1 nitric oxide synthase 1, neuronal affects expression
increases expression
ISO Ouabain affects the expression of NOS1 protein
Ouabain results in increased expression of NOS1 protein
CTD PMID:12384489 PMID:15097235 NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905
JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell multiple interactions
affects expression
increases expression
ISO 5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide inhibits the reaction [Ouabain results in increased expression of NOS3 protein]
Ouabain affects the expression of NOS3 protein
CTD PMID:12384489 PMID:15477225 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472
JBrowse link
G Npc2 NPC intracellular cholesterol transporter 2 decreases expression ISO Ouabain results in decreased expression of NPC2 mRNA CTD PMID:16412265 NCBI chr12:84,801,333...84,819,886
Ensembl chr12:84,801,336...84,819,926
JBrowse link
G Nppa natriuretic peptide type A increases expression
multiple interactions
ISO Ouabain results in increased expression of NPPA mRNA
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased expression of NPPA mRNA]; Ouabain promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]
CTD PMID:17266992 PMID:19687166 NCBI chr 4:148,085,179...148,086,531
Ensembl chr 4:148,085,179...148,086,536
JBrowse link
G Nras neuroblastoma ras oncogene decreases expression ISO Ouabain results in decreased expression of NRAS mRNA CTD PMID:28795476 NCBI chr 3:102,965,601...102,975,230
Ensembl chr 3:102,965,601...102,975,230
JBrowse link
G Park7 Parkinson disease (autosomal recessive, early onset) 7 affects response to substance EXP PARK7 affects the susceptibility to Ouabain CTD PMID:16624565 NCBI chr 4:150,981,590...150,994,378
Ensembl chr 4:150,981,590...150,998,894
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions
increases cleavage
ISO Mitomycin promotes the reaction [Ouabain results in increased cleavage of PARP1 protein]; Ouabain promotes the reaction [Mitomycin results in increased cleavage of PARP1 protein] CTD PMID:24124520 PMID:31436044 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO Ouabain results in decreased expression of PCNA mRNA; Ouabain results in decreased expression of PCNA protein CTD PMID:20460749 PMID:21215801 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
JBrowse link
G Pdcd6 programmed cell death 6 increases expression ISO Ouabain results in increased expression of PDCD6 protein CTD PMID:18247327 NCBI chr13:74,451,240...74,465,445
Ensembl chr13:74,451,628...74,465,699
JBrowse link
G Pfdn5 prefoldin 5 affects expression ISO Ouabain affects the expression of PFDN5 protein CTD PMID:17268060 NCBI chr15:102,234,551...102,239,925
Ensembl chr15:102,234,551...102,240,308
JBrowse link
G Pfn1 profilin 1 affects expression
decreases expression
ISO Ouabain affects the expression of PFN1 protein
Ouabain results in decreased expression of PFN1 protein
CTD PMID:17268060 PMID:18247327 NCBI chr11:70,542,670...70,547,625
Ensembl chr11:70,542,676...70,545,470
JBrowse link
G Plaur plasminogen activator, urokinase receptor decreases expression ISO Ouabain results in decreased expression of PLAUR mRNA CTD PMID:28795476 NCBI chr 7:24,161,857...24,175,393
Ensembl chr 7:24,161,909...24,175,393
JBrowse link
G Plcg1 phospholipase C, gamma 1 decreases expression ISO Ouabain results in decreased expression of PLCG1 mRNA CTD PMID:28795476 NCBI chr 2:160,573,230...160,617,680
Ensembl chr 2:160,573,220...160,617,680
JBrowse link
G Ppt2 palmitoyl-protein thioesterase 2 decreases expression ISO Ouabain results in decreased expression of PPT2 mRNA CTD PMID:16412265 NCBI chr17:34,835,636...34,856,993
Ensembl chr17:34,835,636...34,847,484
JBrowse link
G Prkdc protein kinase, DNA activated, catalytic polypeptide decreases expression ISO Ouabain results in decreased expression of PRKDC protein CTD PMID:31436044 NCBI chr16:15,455,698...15,660,103
Ensembl chr16:15,455,730...15,660,099
JBrowse link
G Psmb6 proteasome (prosome, macropain) subunit, beta type 6 affects expression ISO Ouabain affects the expression of PSMB6 protein CTD PMID:17268060 NCBI chr11:70,416,116...70,418,684
Ensembl chr11:70,416,193...70,418,684
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO [Ouabain results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Nitric Oxide CTD PMID:18976649 NCBI chr 1:149,975,782...149,983,985
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 decreases expression ISO Ouabain results in decreased expression of PTPN2 mRNA CTD PMID:16412265 NCBI chr18:67,798,571...67,857,697
Ensembl chr18:67,798,581...67,857,665
JBrowse link
G Rab11b RAB11B, member RAS oncogene family increases expression ISO Ouabain results in increased expression of RAB11B protein CTD PMID:18247327 NCBI chr17:33,961,458...33,979,460
Ensembl chr17:33,961,458...33,979,504
JBrowse link
G Raf1 v-raf-leukemia viral oncogene 1 decreases expression ISO Ouabain results in decreased expression of RAF1 mRNA CTD PMID:28795476 NCBI chr 6:115,595,530...115,653,596
Ensembl chr 6:115,595,028...115,653,596
JBrowse link
G Rasgrf1 RAS protein-specific guanine nucleotide-releasing factor 1 decreases expression ISO Ouabain results in decreased expression of RASGRF1 mRNA CTD PMID:28795476 NCBI chr 9:89,791,565...89,909,032
Ensembl chr 9:89,791,961...89,909,030
JBrowse link
G Rgs2 regulator of G-protein signaling 2 decreases expression ISO Ouabain results in decreased expression of RGS2 mRNA CTD PMID:28795476 NCBI chr 1:143,875,076...143,879,887
Ensembl chr 1:143,875,076...143,879,899
JBrowse link
G Rhoh ras homolog family member H increases expression ISO Ouabain results in increased expression of RHOH mRNA CTD PMID:28795476 NCBI chr 5:66,018,092...66,054,043
Ensembl chr 5:66,018,556...66,054,043
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 increases cleavage
multiple interactions
ISO Ouabain results in increased cleavage of ROCK1 protein
benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Ouabain results in increased cleavage of ROCK1 protein]
CTD PMID:20661774 NCBI chr18:10,064,401...10,182,225
Ensembl chr18:10,064,401...10,182,045
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 multiple interactions
increases cleavage
ISO benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Ouabain results in increased cleavage of ROCK2 protein] CTD PMID:20661774 NCBI chr12:16,944,808...17,038,275
Ensembl chr12:16,944,896...17,037,824
JBrowse link
G Rpa3 replication protein A3 affects expression ISO Ouabain affects the expression of RPA3 protein CTD PMID:17268060 NCBI chr 6:8,255,936...8,259,141
Ensembl chr 6:8,255,936...8,259,173
JBrowse link
G Rpgrip1l Rpgrip1-like decreases expression ISO Ouabain results in decreased expression of RPGRIP1L mRNA CTD PMID:16412265 NCBI chr 8:91,943,658...92,039,919
Ensembl chr 8:91,943,658...92,039,890
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 affects expression ISO Ouabain affects the expression of RPS6KB1 mRNA CTD PMID:28099878 NCBI chr11:86,389,695...86,435,711
Ensembl chr11:86,389,697...86,435,631
JBrowse link
G Ryr2 ryanodine receptor 2, cardiac multiple interactions
increases response to substance
EXP K201 compound inhibits the reaction [RYR2 mutant form results in increased susceptibility to Ouabain] CTD PMID:20080988 NCBI chr13:11,567,985...12,121,831
Ensembl chr13:11,567,988...12,121,831
JBrowse link
G S100a13 S100 calcium binding protein A13 affects expression ISO Ouabain affects the expression of S100A13 protein CTD PMID:17268060 NCBI chr 3:90,421,539...90,431,888
Ensembl chr 3:90,421,742...90,431,888
JBrowse link
G S100b S100 protein, beta polypeptide, neural increases expression ISO Ouabain results in increased expression of S100B protein CTD PMID:15581912 NCBI chr10:76,089,670...76,097,153
Ensembl chr10:76,089,687...76,096,993
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 multiple interactions
decreases expression
ISO Ouabain inhibits the reaction [SGK1 protein results in increased transport of Potassium]
Ouabain results in decreased expression of SGK1 mRNA
CTD PMID:12590200 PMID:28795476 NCBI chr10:21,758,083...21,875,802
Ensembl chr10:21,758,083...21,875,802
JBrowse link
G Sgk2 serum/glucocorticoid regulated kinase 2 multiple interactions ISO Ouabain inhibits the reaction [SGK2 protein results in increased transport of Potassium] CTD PMID:12590200 NCBI chr 2:162,829,249...162,856,059
Ensembl chr 2:162,829,250...162,856,047
JBrowse link
G Sgk3 serum/glucocorticoid regulated kinase 3 multiple interactions ISO Ouabain inhibits the reaction [SGK3 protein results in increased transport of Potassium] CTD PMID:12590200 NCBI chr 1:9,868,355...9,972,795
Ensembl chr 1:9,868,332...9,971,070
JBrowse link
G Shc3 src homology 2 domain-containing transforming protein C3 increases expression ISO Ouabain results in increased expression of SHC3 mRNA CTD PMID:28795476 NCBI chr13:51,577,422...51,724,909
Ensembl chr13:51,585,077...51,723,523
JBrowse link
G Slc16a1 solute carrier family 16 (monocarboxylic acid transporters), member 1 multiple interactions ISO Ouabain inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid] CTD PMID:15804185 NCBI chr 3:104,545,980...104,565,778
Ensembl chr 3:104,545,984...104,565,778
JBrowse link
G Slc22a12 solute carrier family 22 (organic anion/cation transporter), member 12 multiple interactions EXP Ouabain promotes the reaction [SLC22A12 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:15284287 NCBI chr19:6,585,884...6,593,100
Ensembl chr19:6,585,875...6,593,062
JBrowse link
G Slc5a5 solute carrier family 5 (sodium iodide symporter), member 5 multiple interactions ISO Ouabain inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide] CTD PMID:12541134 NCBI chr 8:71,335,529...71,345,429
Ensembl chr 8:71,335,533...71,345,401
JBrowse link
G Slc5a6 solute carrier family 5 (sodium-dependent vitamin transporter), member 6 multiple interactions ISO Ouabain inhibits the reaction [SLC5A6 protein results in increased transport of Biotin] CTD PMID:15561972 NCBI chr 5:31,193,380...31,206,268
Ensembl chr 5:31,193,380...31,206,268
JBrowse link
G Slc8a1 solute carrier family 8 (sodium/calcium exchanger), member 1 affects response to substance
increases expression
multiple interactions
EXP
ISO
SLC8A1 affects the susceptibility to Ouabain
Ouabain results in increased expression of SLC8A1 protein
SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]; SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]
CTD PMID:16166162 PMID:19897708 NCBI chr17:81,680,534...82,045,816
Ensembl chr17:81,680,534...82,045,806
JBrowse link
G Slc9a1 solute carrier family 9 (sodium/hydrogen exchanger), member 1 multiple interactions
increases expression
ISO N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased expression of SLC9A1 mRNA] CTD PMID:19687166 NCBI chr 4:133,097,022...133,151,013
Ensembl chr 4:133,097,017...133,151,013
JBrowse link
G Smad4 SMAD family member 4 decreases expression ISO Ouabain results in decreased expression of SMAD4 mRNA CTD PMID:28795476 NCBI chr18:73,767,861...73,836,862
Ensembl chr18:73,772,080...73,836,851
JBrowse link
G Snai1 snail family zinc finger 1 decreases expression ISO Ouabain results in decreased expression of SNAI1 mRNA CTD PMID:33760381 NCBI chr 2:167,380,115...167,384,734
Ensembl chr 2:167,380,115...167,384,734
JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 decreases expression ISO Ouabain results in decreased expression of SOS1 protein CTD PMID:28795476 NCBI chr17:80,701,181...80,787,882
Ensembl chr17:80,701,180...80,787,882
JBrowse link
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 decreases expression ISO Ouabain results in decreased expression of SOS2 mRNA CTD PMID:28795476 NCBI chr12:69,630,535...69,728,626
Ensembl chr12:69,630,536...69,728,626
JBrowse link
G Sphk1 sphingosine kinase 1 decreases expression ISO Ouabain results in decreased expression of SPHK1 mRNA CTD PMID:28795476 NCBI chr11:116,421,662...116,427,502
Ensembl chr11:116,421,751...116,427,501
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression ISO Ouabain results in decreased expression of TGFB1 mRNA CTD PMID:28795476 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link
G Tgfb2 transforming growth factor, beta 2 decreases expression ISO Ouabain results in decreased expression of TGFB2 mRNA CTD PMID:28795476 NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186
JBrowse link
G Tgfb3 transforming growth factor, beta 3 decreases expression ISO Ouabain results in decreased expression of TGFB3 mRNA CTD PMID:28795476 NCBI chr12:86,103,517...86,125,815
Ensembl chr12:86,103,519...86,125,815
JBrowse link
G Tgfbr3 transforming growth factor, beta receptor III increases expression ISO Ouabain results in increased expression of TGFBR3 mRNA CTD PMID:28795476 NCBI chr 5:107,254,433...107,437,495
Ensembl chr 5:107,254,436...107,437,495
JBrowse link
G Tln1 talin 1 decreases expression ISO Ouabain results in decreased expression of TLN1 mRNA CTD PMID:28795476 NCBI chr 4:43,531,513...43,562,583
Ensembl chr 4:43,531,519...43,562,691
JBrowse link
G Tln2 talin 2 decreases expression ISO Ouabain results in decreased expression of TLN2 mRNA CTD PMID:28795476 NCBI chr 9:67,124,367...67,541,357
Ensembl chr 9:67,124,369...67,466,985
JBrowse link
G Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b increases expression ISO Ouabain results in increased expression of TNFRSF10A protein CTD PMID:31436044 NCBI chr14:70,004,921...70,021,860
Ensembl chr14:70,004,921...70,021,860
JBrowse link
G Tpi1 triosephosphate isomerase 1 affects expression ISO Ouabain affects the expression of TPI1 protein CTD PMID:17268060 NCBI chr 6:124,787,549...124,791,121
Ensembl chr 6:124,787,549...124,791,259
JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 affects expression ISO Ouabain affects the expression of TPT1 protein CTD PMID:17268060 NCBI chr14:76,082,472...76,085,743
Ensembl chr14:76,082,533...76,085,965
JBrowse link
G Trim63 tripartite motif-containing 63 multiple interactions EXP [Ouabain co-treated with Botulinum Toxins, Type A] affects the expression of TRIM63 mRNA CTD PMID:21139329 NCBI chr 4:134,042,431...134,056,940
Ensembl chr 4:134,042,431...134,056,940
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO Ouabain results in decreased expression of and results in increased phosphorylation of TP53 protein CTD PMID:31436044 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 increases expression ISO Ouabain results in increased expression of TRPC1 protein CTD PMID:19897708 NCBI chr 9:95,587,125...95,632,438
Ensembl chr 9:95,587,135...95,632,428
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 increases expression
multiple interactions
ISO Ouabain results in increased expression of TRPC6 protein
SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]
CTD PMID:19897708 NCBI chr 9:8,543,868...8,680,753
Ensembl chr 9:8,544,143...8,680,742
JBrowse link
G Twist1 twist basic helix-loop-helix transcription factor 1 increases expression ISO Ouabain results in increased expression of TWIST1 mRNA CTD PMID:33760381 NCBI chr12:34,007,670...34,009,830
Ensembl chr12:34,007,670...34,009,828
JBrowse link
G Txn1 thioredoxin 1 affects expression ISO Ouabain affects the expression of TXN protein CTD PMID:17268060 NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411
JBrowse link
G Vim vimentin decreases expression ISO Ouabain results in decreased expression of VIM mRNA CTD PMID:33760381 NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637
JBrowse link
G Zfhx3 zinc finger homeobox 3 decreases expression ISO Ouabain results in decreased expression of ZFHX3 mRNA CTD PMID:16412265 NCBI chr 8:109,005,975...109,688,268
Ensembl chr 8:108,669,276...109,688,262
JBrowse link
strophanthidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A increases transport ISO ABCB1 protein results in increased transport of Strophanthidin CTD PMID:26708294 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
JBrowse link
G G6pc glucose-6-phosphatase, catalytic increases expression
multiple interactions
ISO Strophanthidin results in increased expression of G6PC1 mRNA
Strophanthidin promotes the reaction [RORC protein binds to G6PC1 promoter]
CTD PMID:29981919 NCBI chr11:101,258,542...101,268,729
Ensembl chr11:101,258,387...101,268,729
JBrowse link
G Il17a interleukin 17A multiple interactions ISO Strophanthidin results in increased expression of and results in increased secretion of IL17A protein CTD PMID:29981919 NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720
JBrowse link
G Il17f interleukin 17F multiple interactions ISO Strophanthidin results in increased expression of and results in increased secretion of IL17F protein CTD PMID:29981919 NCBI chr 1:20,847,370...20,855,498
Ensembl chr 1:20,847,370...20,860,841
JBrowse link
G Npas2 neuronal PAS domain protein 2 multiple interactions
increases expression
ISO Strophanthidin promotes the reaction [RORC protein binds to NPAS2 promoter]
Strophanthidin results in increased expression of NPAS2 mRNA
CTD PMID:29981919 NCBI chr 1:39,233,013...39,402,321
Ensembl chr 1:39,232,812...39,402,317
JBrowse link
G Rorc RAR-related orphan receptor gamma increases expression
multiple interactions
ISO Strophanthidin results in increased expression of RORC mRNA
RORC protein promotes the reaction [Strophanthidin results in increased expression of RORC mRNA]; Strophanthidin promotes the reaction [RORC protein binds to G6PC1 promoter]; Strophanthidin promotes the reaction [RORC protein binds to NPAS2 promoter]
CTD PMID:29981919 NCBI chr 3:94,280,101...94,305,583
Ensembl chr 3:94,280,101...94,305,583
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21873
    chemical entity 21871
      molecular entity 21862
        polyatomic entity 21761
          heteroatomic molecular entity 21681
            hydroxides 20464
              organic hydroxy compound 19503
                hydroxy steroid 14302
                  5-hydroxy steroid 207
                    5alpha-hydroxy steroid + 0
                    5beta-hydroxy steroid + 207
Path 2
Term Annotations click to browse term
  CHEBI ontology 21873
    subatomic particle 21863
      composite particle 21863
        hadron 21863
          baryon 21863
            nucleon 21863
              atomic nucleus 21863
                atom 21863
                  main group element atom 21785
                    p-block element atom 21785
                      carbon group element atom 21593
                        carbon atom 21514
                          organic molecular entity 21514
                            organic molecule 21380
                              organic cyclic compound 20985
                                organic polycyclic compound 17884
                                  steroid 14600
                                    hydroxy steroid 14302
                                      5-hydroxy steroid 207
                                        5alpha-hydroxy steroid + 0
                                        5beta-hydroxy steroid + 207
paths to the root