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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:5-hydroxy steroid
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Accession:CHEBI:36848 term browser browse the term
Synonyms:related_synonym: 5-hydroxy steroids



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dihydroouabain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G G6PC1 glucose-6-phosphatase catalytic subunit 1 increases expression
multiple interactions
EXP dihydroouabain results in increased expression of G6PC1 mRNA
dihydroouabain promotes the reaction [RORC protein binds to G6PC1 promoter]
CTD PMID:29981919 NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438
JBrowse link
G IL17A interleukin 17A multiple interactions EXP dihydroouabain results in increased expression of and results in increased secretion of IL17A protein CTD PMID:29981919 NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638
JBrowse link
G IL17F interleukin 17F multiple interactions EXP dihydroouabain results in increased expression of and results in increased secretion of IL17F protein CTD PMID:29981919 NCBI chr 6:52,236,681...52,245,689
Ensembl chr 6:52,236,681...52,245,689
JBrowse link
G NPAS2 neuronal PAS domain protein 2 multiple interactions
increases expression
EXP dihydroouabain promotes the reaction [RORC protein binds to NPAS2 promoter]
dihydroouabain results in increased expression of NPAS2 mRNA
CTD PMID:29981919 NCBI chr 2:100,818,723...100,996,829
Ensembl chr 2:100,820,139...100,996,829
JBrowse link
G RORC RAR related orphan receptor C multiple interactions
increases expression
EXP dihydroouabain promotes the reaction [RORC protein binds to G6PC1 promoter]; dihydroouabain promotes the reaction [RORC protein binds to NPAS2 promoter]; RORC protein promotes the reaction [dihydroouabain results in increased expression of RORC mRNA] CTD PMID:29981919 NCBI chr 1:151,806,071...151,831,802
Ensembl chr 1:151,806,071...151,831,845
JBrowse link
hellebrigenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions EXP hellebrigenin results in decreased phosphorylation of and results in decreased expression of AKT1 protein CTD PMID:24954031 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G ATM ATM serine/threonine kinase increases phosphorylation EXP hellebrigenin results in increased phosphorylation of ATM protein CTD PMID:24954031 NCBI chr11:108,223,067...108,369,102
Ensembl chr11:108,223,044...108,369,102
JBrowse link
G BAX BCL2 associated X, apoptosis regulator affects localization EXP hellebrigenin affects the localization of BAX protein CTD PMID:24954031 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G CCNB1 cyclin B1 increases expression EXP hellebrigenin results in increased expression of CCNB1 protein CTD PMID:24954031 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245
JBrowse link
G CDC25C cell division cycle 25C decreases phosphorylation EXP hellebrigenin results in decreased phosphorylation of CDC25C protein CTD PMID:24954031 NCBI chr 5:138,285,265...138,338,355
Ensembl chr 5:138,285,269...138,338,355
JBrowse link
G CDK1 cyclin dependent kinase 1 increases phosphorylation EXP hellebrigenin results in increased phosphorylation of CDK1 protein CTD PMID:24954031 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852
JBrowse link
G CHEK2 checkpoint kinase 2 increases phosphorylation EXP hellebrigenin results in increased phosphorylation of CHEK2 protein CTD PMID:24954031 NCBI chr22:28,687,743...28,741,834
Ensembl chr22:28,687,743...28,742,422
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases activity EXP hellebrigenin results in increased activity of PARP1 protein CTD PMID:24954031 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154
JBrowse link
ouabain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2M alpha-2-macroglobulin affects expression EXP Ouabain affects the expression of A2M protein CTD PMID:17268060 NCBI chr12:9,067,708...9,116,229
Ensembl chr12:9,067,664...9,116,229
JBrowse link
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions
increases expression
EXP 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain results in increased expression of ABCB1 protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain results in increased expression of ABCB1 mRNA]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain results in increased expression of ABCB1 protein]; [Ouabain results in increased expression of ABCB1] which results in decreased susceptibility to Doxorubicin; KN 93 inhibits the reaction [Ouabain results in increased expression of ABCB1 protein]
Ouabain results in increased expression of ABCB1 mRNA; Ouabain results in increased expression of ABCB1 protein
CTD PMID:19647009 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ACAA2 acetyl-CoA acyltransferase 2 affects expression EXP Ouabain affects the expression of ACAA2 protein CTD PMID:17268060 NCBI chr18:49,782,164...49,813,533
Ensembl chr18:49,782,164...49,813,953
JBrowse link
G ACE angiotensin I converting enzyme affects expression ISO Ouabain affects the expression of ACE mRNA; Ouabain affects the expression of ACE protein CTD PMID:16565308 NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380
JBrowse link
G ACTA2 actin alpha 2, smooth muscle affects expression EXP Ouabain affects the expression of ACTA2 protein CTD PMID:17268060 NCBI chr10:88,935,074...88,991,397
Ensembl chr10:88,935,074...88,991,339
JBrowse link
G ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide affects expression EXP Ouabain affects the expression of ADH1C protein CTD PMID:17268060 NCBI chr 4:99,336,497...99,352,746
Ensembl chr 4:99,336,497...99,352,746
JBrowse link
G AGT angiotensinogen affects expression
increases expression
ISO Ouabain affects the expression of AGT protein
Ouabain results in increased expression of AGT protein
CTD PMID:11768735 PMID:16565308 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576
JBrowse link
G AGTR1 angiotensin II receptor type 1 affects expression
decreases expression
ISO Ouabain affects the expression of AGTR1A mRNA
Ouabain results in decreased expression of AGTR1A protein
CTD PMID:16565308 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008
JBrowse link
G AIFM1 apoptosis inducing factor mitochondria associated 1 increases expression EXP Ouabain results in increased expression of AIFM1 protein CTD PMID:31436044 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879
JBrowse link
G ANXA1 annexin A1 affects expression EXP Ouabain affects the expression of ANXA1 protein CTD PMID:17268060 NCBI chr 9:73,151,865...73,170,393
Ensembl chr 9:73,151,865...73,170,393
JBrowse link
G ANXA2 annexin A2 affects expression EXP Ouabain affects the expression of ANXA2 protein CTD PMID:17268060 NCBI chr15:60,347,151...60,397,986
Ensembl chr15:60,347,134...60,402,883
JBrowse link
G APAF1 apoptotic peptidase activating factor 1 increases expression EXP Ouabain results in increased expression of APAF1 protein CTD PMID:31436044 NCBI chr12:98,645,290...98,735,433
Ensembl chr12:98,645,290...98,735,433
JBrowse link
G ARAF A-Raf proto-oncogene, serine/threonine kinase decreases expression EXP Ouabain results in decreased expression of ARAF mRNA CTD PMID:16412265 NCBI chr  X:47,561,205...47,571,908
Ensembl chr  X:47,561,205...47,571,908
JBrowse link
G ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 decreases expression EXP Ouabain results in decreased expression of ARIH1 mRNA CTD PMID:16412265 NCBI chr15:72,474,330...72,602,987
Ensembl chr15:72,474,330...72,602,987
JBrowse link
G ARPC5 actin related protein 2/3 complex subunit 5 affects expression EXP Ouabain affects the expression of ARPC5 protein CTD PMID:17268060 NCBI chr 1:183,620,846...183,635,783
Ensembl chr 1:183,620,846...183,635,783
JBrowse link
G ARRB1 arrestin beta 1 increases expression EXP Ouabain results in increased expression of ARRB1 mRNA CTD PMID:16412265 NCBI chr11:75,260,122...75,351,661
Ensembl chr11:75,260,122...75,351,705
JBrowse link
G ASAH1 N-acylsphingosine amidohydrolase 1 affects expression EXP Ouabain affects the expression of ASAH1 protein CTD PMID:17268060 NCBI chr 8:18,055,992...18,084,961
Ensembl chr 8:18,055,992...18,084,998
JBrowse link
G ATF6B activating transcription factor 6 beta increases expression EXP Ouabain results in increased expression of ATF6B protein CTD PMID:31436044 NCBI chr 6:32,115,264...32,128,246
Ensembl chr 6:32,115,264...32,128,253
JBrowse link
G ATM ATM serine/threonine kinase increases phosphorylation EXP Ouabain results in increased phosphorylation of ATM protein CTD PMID:31436044 NCBI chr11:108,223,067...108,369,102
Ensembl chr11:108,223,044...108,369,102
JBrowse link
G ATP12A ATPase H+/K+ transporting non-gastric alpha2 subunit multiple interactions EXP Ouabain inhibits the reaction [[ATP12A protein co-treated with ATP4B protein] results in increased uptake of Rubidium] CTD PMID:8853415 NCBI chr13:24,680,408...24,712,472
Ensembl chr13:24,680,408...24,712,472
JBrowse link
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 multiple interactions
affects binding
increases expression
affects expression
EXP
ISO
Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A1 mRNA]; Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A1 protein]
Ouabain binds to ATP1A1 protein
Ouabain results in increased expression of ATP1A1 mRNA; Ouabain results in increased expression of ATP1A1 protein
Ouabain affects the expression of ATP1A1 protein
CTD PMID:11768735 PMID:11834625 PMID:12479229 PMID:16716361 PMID:19995221 NCBI chr 1:116,373,244...116,404,774
Ensembl chr 1:116,372,668...116,410,261
JBrowse link
G ATP1A2 ATPase Na+/K+ transporting subunit alpha 2 multiple interactions
affects binding
increases expression
affects response to substance
decreases activity
affects expression
decreases expression
EXP
ISO
Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A2 mRNA]
Ouabain binds to ATP1A2 protein
ATP1A2 protein affects the susceptibility to Ouabain
Ouabain binds to and results in decreased activity of ATP1A2 protein
Ouabain results in decreased activity of ATP1A2 protein
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in decreased expression of ATP1A2 mRNA]
Ouabain affects the expression of ATP1A2 protein
Ouabain results in increased expression of ATP1A2 protein
CTD PMID:11834625 PMID:12479229 PMID:15458945 PMID:16166162 PMID:16716361 More... NCBI chr 1:160,115,759...160,143,591
Ensembl chr 1:160,115,759...160,143,591
JBrowse link
G ATP1A3 ATPase Na+/K+ transporting subunit alpha 3 increases expression
affects binding
multiple interactions
affects expression
decreases expression
EXP
ISO
Ouabain results in increased expression of ATP1A3 mRNA; Ouabain results in increased expression of ATP1A3 protein
ATP1A3 protein binds to Ouabain; Ouabain binds to ATP1A3 protein
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in decreased expression of ATP1A3 mRNA]
Ouabain affects the expression of ATP1A3 protein
Potassium Chloride inhibits the reaction [ATP1A3 protein binds to Ouabain]
CTD PMID:11204457 PMID:12479229 PMID:15276875 PMID:19687166 PMID:19995221 More... NCBI chr19:41,966,582...41,994,230
Ensembl chr19:41,966,582...41,997,497
JBrowse link
G ATP1B1 ATPase Na+/K+ transporting subunit beta 1 multiple interactions
increases expression
ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Ouabain results in increased expression of ATP1B1 mRNA]; Calcium affects the reaction [Ouabain results in increased expression of ATP1B1 mRNA]; W 7 inhibits the reaction [Ouabain results in increased expression of ATP1B1 mRNA] CTD PMID:11204457 NCBI chr 1:169,106,690...169,132,719
Ensembl chr 1:169,105,697...169,310,992
JBrowse link
G ATP4B ATPase H+/K+ transporting subunit beta multiple interactions EXP Ouabain inhibits the reaction [[ATP12A protein co-treated with ATP4B protein] results in increased uptake of Rubidium] CTD PMID:8853415 NCBI chr13:113,648,804...113,658,198
Ensembl chr13:113,648,804...113,658,198
JBrowse link
G ATP5F1A ATP synthase F1 subunit alpha affects expression EXP Ouabain affects the expression of ATP5F1A protein CTD PMID:17268060 NCBI chr18:46,080,248...46,104,227
Ensembl chr18:46,080,248...46,104,334
JBrowse link
G ATR ATR serine/threonine kinase decreases phosphorylation EXP Ouabain results in decreased phosphorylation of ATR protein CTD PMID:31436044 NCBI chr 3:142,449,235...142,578,733
Ensembl chr 3:142,449,007...142,578,733
JBrowse link
G BAHD1 bromo adjacent homology domain containing 1 decreases expression EXP Ouabain results in decreased expression of BAHD1 mRNA CTD PMID:16412265 NCBI chr15:40,437,452...40,468,236
Ensembl chr15:40,439,721...40,468,236
JBrowse link
G BAX BCL2 associated X, apoptosis regulator affects localization
multiple interactions
increases expression
EXP Ouabain affects the localization of BAX protein
Ouabain inhibits the reaction [HSPD1 protein binds to BAX protein]
Ouabain results in increased expression of BAX protein
CTD PMID:17096883 PMID:18247327 PMID:31436044 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP Ouabain results in decreased expression of BCL2 protein CTD PMID:31436044 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 decreases expression EXP Ouabain results in decreased expression of BCL2L1 protein CTD PMID:31436044 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G BDNF brain derived neurotrophic factor multiple interactions
decreases expression
ISO Lithium inhibits the reaction [Ouabain results in decreased expression of BDNF protein] CTD PMID:19954800 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058
JBrowse link
G BRCA1 BRCA1 DNA repair associated decreases expression EXP Ouabain results in decreased expression of BRCA1 protein CTD PMID:31436044 NCBI chr17:43,044,295...43,125,364
Ensembl chr17:43,044,295...43,170,245
JBrowse link
G CALB1 calbindin 1 decreases expression ISO Ouabain results in decreased expression of CALB1 protein CTD PMID:20105455 NCBI chr 8:90,058,608...90,082,879
Ensembl chr 8:90,058,608...90,095,475
JBrowse link
G CALML5 calmodulin like 5 affects expression EXP Ouabain affects the expression of CALML5 protein CTD PMID:17268060 NCBI chr10:5,498,697...5,499,570
Ensembl chr10:5,498,697...5,499,570
JBrowse link
G CAMK2B calcium/calmodulin dependent protein kinase II beta increases expression EXP Ouabain results in increased expression of CAMK2B protein CTD PMID:31436044 NCBI chr 7:44,217,154...44,326,013
Ensembl chr 7:44,210,019...44,334,577
JBrowse link
G CANX calnexin increases expression EXP Ouabain results in increased expression of CANX protein CTD PMID:18247327 NCBI chr 5:179,678,656...179,731,641
Ensembl chr 5:179,678,628...179,731,641
JBrowse link
G CASP3 caspase 3 increases expression
increases activity
multiple interactions
EXP
ISO
Ouabain results in increased expression of CASP3 protein
Ouabain results in increased activity of CASP3 protein
Ouabain results in increased activity of and results in increased cleavage of CASP3 protein
CTD PMID:11435898 PMID:17096883 PMID:18247327 PMID:20435043 PMID:31436044 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CASP4 caspase 4 increases expression EXP Ouabain results in increased expression of CASP4 protein CTD PMID:31436044 NCBI chr11:104,942,866...104,968,574
Ensembl chr11:104,942,866...104,969,366
JBrowse link
G CASP8 caspase 8 multiple interactions EXP Ouabain results in increased expression of and results in increased activity of CASP8 protein CTD PMID:31436044 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,361,836
JBrowse link
G CASP9 caspase 9 multiple interactions EXP Ouabain results in increased expression of and results in increased activity of CASP9 protein CTD PMID:31436044 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase multiple interactions
decreases activity
ISO Lithium inhibits the reaction [Ouabain results in decreased activity of CAT protein]; Valproic Acid inhibits the reaction [Ouabain results in decreased activity of CAT protein] CTD PMID:20627318 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CAV1 caveolin 1 decreases expression EXP Ouabain results in decreased expression of CAV1 mRNA CTD PMID:28795476 NCBI chr 7:116,525,009...116,561,185
Ensembl chr 7:116,524,994...116,561,179
JBrowse link
G CCDC14 coiled-coil domain containing 14 decreases expression EXP Ouabain results in decreased expression of CCDC14 mRNA CTD PMID:16412265 NCBI chr 3:123,885,176...123,961,229
Ensembl chr 3:123,897,305...123,961,408
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions
increases expression
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Ouabain results in increased expression of CCL2 mRNA]; Amiloride inhibits the reaction [Ouabain results in increased expression of CCL2 protein]; Sodium deficiency inhibits the reaction [Ouabain results in increased expression of CCL2 mRNA]; Sodium deficiency inhibits the reaction [Ouabain results in increased expression of CCL2 protein]
Ouabain results in increased expression of CCL2 mRNA; Ouabain results in increased expression of CCL2 protein
CTD PMID:11340305 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208
JBrowse link
G CCNA1 cyclin A1 decreases expression EXP Ouabain results in decreased expression of CCNA1 mRNA CTD PMID:20460749 NCBI chr13:36,431,517...36,442,870
Ensembl chr13:36,431,520...36,442,870
JBrowse link
G CCNA2 cyclin A2 decreases expression EXP Ouabain results in decreased expression of CCNA2 mRNA CTD PMID:21215801 NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883
JBrowse link
G CCND1 cyclin D1 decreases expression EXP Ouabain results in decreased expression of CCND1 mRNA CTD PMID:28795476 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CDH1 cadherin 1 increases expression
decreases expression
EXP Ouabain results in increased expression of CDH1 mRNA
Ouabain results in decreased expression of CDH1 protein
CTD PMID:28795476 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537
JBrowse link
G CDH2 cadherin 2 decreases expression EXP Ouabain results in decreased expression of CDH2 mRNA; Ouabain results in decreased expression of CDH2 protein CTD PMID:28795476 NCBI chr18:27,932,879...28,177,130
Ensembl chr18:27,932,879...28,177,946
JBrowse link
G CDK2 cyclin dependent kinase 2 decreases expression EXP Ouabain results in decreased expression of CDK2 mRNA; Ouabain results in decreased expression of CDK2 protein CTD PMID:20460749 PMID:21215801 PMID:31436044 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789
JBrowse link
G CDK6 cyclin dependent kinase 6 decreases expression EXP Ouabain results in decreased expression of CDK6 protein CTD PMID:31436044 NCBI chr 7:92,604,921...92,836,573
Ensembl chr 7:92,604,921...92,836,573
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A decreases expression
increases expression
EXP Ouabain results in decreased expression of CDKN1A mRNA; Ouabain results in decreased expression of CDKN1A protein
Ouabain results in increased expression of CDKN1A mRNA; Ouabain results in increased expression of CDKN1A protein
CTD PMID:20460749 PMID:21215801 PMID:28795476 PMID:31436044 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337
JBrowse link
G CKB creatine kinase B decreases activity ISO Ouabain results in decreased activity of CKB protein CTD PMID:19911114 NCBI chr14:103,519,667...103,522,830
Ensembl chr14:103,519,667...103,522,833
JBrowse link
G CLDN1 claudin 1 decreases expression EXP Ouabain results in decreased expression of CLDN1 protein CTD PMID:18247327 NCBI chr 3:190,305,707...190,322,446
Ensembl chr 3:190,305,707...190,322,446
JBrowse link
G CNPY2 canopy FGF signaling regulator 2 affects expression EXP Ouabain affects the expression of CNPY2 protein CTD PMID:17268060 NCBI chr12:56,309,844...56,316,346
Ensembl chr12:56,309,842...56,316,119
JBrowse link
G COL1A1 collagen type I alpha 1 chain increases expression
multiple interactions
ISO Ouabain results in increased expression of COL1A1 mRNA
MIR29B1 mRNA inhibits the reaction [Ouabain results in increased expression of COL1A1 mRNA]
CTD PMID:26702050 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632
JBrowse link
G CS citrate synthase decreases activity ISO Ouabain results in decreased activity of CS protein CTD PMID:20372980 NCBI chr12:56,271,699...56,300,330
Ensembl chr12:56,271,699...56,300,391
JBrowse link
G CYC1 cytochrome c1 multiple interactions EXP Ouabain results in decreased expression of and affects the localization of CYC1 protein CTD PMID:18247327 NCBI chr 8:144,095,076...144,097,525
Ensembl chr 8:144,095,039...144,097,525
JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases expression EXP Ouabain results in increased expression of DDIT3 protein CTD PMID:31436044 NCBI chr12:57,516,588...57,521,698
Ensembl chr12:57,516,588...57,521,737
JBrowse link
G DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit decreases expression EXP Ouabain results in decreased expression of DDOST mRNA CTD PMID:16412265 NCBI chr 1:20,651,777...20,661,369
Ensembl chr 1:20,651,767...20,661,544
JBrowse link
G DNAJA3 DnaJ heat shock protein family (Hsp40) member A3 increases expression EXP Ouabain results in increased expression of DNAJA3 mRNA CTD PMID:28795476 NCBI chr16:4,425,868...4,456,775
Ensembl chr16:4,425,805...4,456,775
JBrowse link
G DRD1 dopamine receptor D1 multiple interactions
decreases expression
EXP
ISO
Ouabain results in decreased expression of and results in increased phosphorylation of DRD1 protein
Ouabain results in decreased expression of DRD1 mRNA
Ouabain results in increased phosphorylation of and results in decreased expression of DRD1 protein
CTD PMID:19626329 PMID:20132239 NCBI chr 5:175,440,036...175,444,182
Ensembl chr 5:175,440,036...175,444,182
JBrowse link
G DSG1 desmoglein 1 affects expression EXP Ouabain affects the expression of DSG1 protein CTD PMID:17268060 NCBI chr18:31,318,160...31,359,246
Ensembl chr18:31,318,160...31,359,246
JBrowse link
G DUT deoxyuridine triphosphatase affects expression EXP Ouabain affects the expression of DUT protein CTD PMID:17268060 NCBI chr15:48,331,095...48,343,373
Ensembl chr15:48,331,011...48,343,373
JBrowse link
G ECE1 endothelin converting enzyme 1 increases expression EXP Ouabain results in increased expression of ECE1 protein CTD PMID:18247327 NCBI chr 1:21,217,250...21,345,504
Ensembl chr 1:21,217,247...21,345,572
JBrowse link
G ECHS1 enoyl-CoA hydratase, short chain 1 affects expression EXP Ouabain affects the expression of ECHS1 protein CTD PMID:17268060 NCBI chr10:133,362,485...133,373,354
Ensembl chr10:133,362,485...133,373,354
JBrowse link
G EDN1 endothelin 1 increases expression
decreases expression
ISO
EXP
Ouabain results in increased expression of EDN1 mRNA
Ouabain results in decreased expression of EDN1 mRNA
CTD PMID:15477225 PMID:28795476 NCBI chr 6:12,256,484...12,297,194
Ensembl chr 6:12,290,361...12,297,194
JBrowse link
G EDNRA endothelin receptor type A increases expression ISO Ouabain results in increased expression of EDNRA mRNA; Ouabain results in increased expression of EDNRA protein CTD PMID:15477225 PMID:16982439 NCBI chr 4:147,481,097...147,544,954
Ensembl chr 4:147,480,917...147,544,954
JBrowse link
G EGFR epidermal growth factor receptor decreases phosphorylation EXP Ouabain results in decreased phosphorylation of EGFR protein CTD PMID:28795476 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G EIF2A eukaryotic translation initiation factor 2A increases expression EXP Ouabain results in increased expression of EIF2A protein CTD PMID:31436044 NCBI chr 3:150,546,787...150,586,016
Ensembl chr 3:150,546,678...150,586,016
JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP Ouabain results in increased expression of and results in increased phosphorylation of EIF2AK3 protein CTD PMID:31436044 NCBI chr 2:88,556,741...88,628,145
Ensembl chr 2:88,556,741...88,691,518
JBrowse link
G EIF3K eukaryotic translation initiation factor 3 subunit K affects expression EXP Ouabain affects the expression of EIF3K protein CTD PMID:17268060 NCBI chr19:38,619,188...38,636,954
Ensembl chr19:38,619,082...38,636,955
JBrowse link
G ENDOG endonuclease G increases expression EXP Ouabain results in increased expression of ENDOG protein CTD PMID:31436044 NCBI chr 9:128,818,500...128,822,676
Ensembl chr 9:128,818,500...128,822,676
JBrowse link
G ERCC4 ERCC excision repair 4, endonuclease catalytic subunit decreases expression EXP Ouabain results in decreased expression of ERCC4 mRNA CTD PMID:24124520 NCBI chr16:13,920,154...13,952,348
Ensembl chr16:13,920,138...13,952,348
JBrowse link
G ETS1 ETS proto-oncogene 1, transcription factor decreases expression EXP Ouabain results in decreased expression of ETS1 mRNA CTD PMID:28795476 NCBI chr11:128,458,765...128,587,558
Ensembl chr11:128,458,761...128,587,558
JBrowse link
G FADD Fas associated via death domain increases expression EXP Ouabain results in increased expression of FADD protein CTD PMID:31436044 NCBI chr11:70,203,296...70,207,390
Ensembl chr11:70,203,296...70,207,390
JBrowse link
G FANCD2 FA complementation group D2 multiple interactions
decreases expression
EXP Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]; SB 203580 inhibits the reaction [Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]]
Ouabain results in decreased expression of FANCD2 mRNA
CTD PMID:24124520 NCBI chr 3:10,026,437...10,101,932
Ensembl chr 3:10,026,370...10,101,932
JBrowse link
G FANCF FA complementation group F decreases expression EXP Ouabain results in decreased expression of FANCF mRNA CTD PMID:24124520 NCBI chr11:22,622,533...22,625,823
Ensembl chr11:22,622,533...22,625,823
JBrowse link
G FANCI FA complementation group I decreases expression
multiple interactions
EXP Ouabain results in decreased expression of FANCI mRNA
Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein]
CTD PMID:24124520 NCBI chr15:89,243,979...89,317,259
Ensembl chr15:89,243,945...89,317,261
JBrowse link
G FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial increases expression EXP Ouabain results in increased expression of FARS2 mRNA CTD PMID:16412265 NCBI chr 6:5,249,934...5,771,583
Ensembl chr 6:5,261,044...5,829,192
JBrowse link
G FAS Fas cell surface death receptor increases expression EXP Ouabain results in increased expression of FAS protein CTD PMID:31436044 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605
JBrowse link
G FASLG Fas ligand increases expression EXP Ouabain results in increased expression of FASLG protein CTD PMID:31436044 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876
JBrowse link
G FBXO32 F-box protein 32 multiple interactions ISO Ouabain affects the reaction [Botulinum Toxins, Type A affects the expression of FBXO32 mRNA] CTD PMID:21139329 NCBI chr 8:123,497,889...123,541,206
Ensembl chr 8:123,497,889...123,541,206
JBrowse link
G FH fumarate hydratase affects expression EXP Ouabain affects the expression of FH protein CTD PMID:17268060 NCBI chr 1:241,497,603...241,519,755
Ensembl chr 1:241,497,511...241,519,799
JBrowse link
G FKBP7 FKBP prolyl isomerase 7 increases expression EXP Ouabain results in increased expression of FKBP7 mRNA CTD PMID:16412265 NCBI chr 2:178,463,664...178,478,600
Ensembl chr 2:178,463,664...178,478,600
JBrowse link
G FN1 fibronectin 1 decreases expression EXP Ouabain results in decreased expression of FN1 mRNA CTD PMID:28795476 NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073
JBrowse link
G GC GC vitamin D binding protein affects expression EXP Ouabain affects the expression of GC protein CTD PMID:17268060 NCBI chr 4:71,741,693...71,805,520
Ensembl chr 4:71,741,696...71,804,041
JBrowse link
G GLRB glycine receptor beta increases expression EXP Ouabain results in increased expression of GLRB mRNA CTD PMID:16412265 NCBI chr 4:157,076,150...157,172,090
Ensembl chr 4:157,076,125...157,172,090
JBrowse link
G GRB2 growth factor receptor bound protein 2 decreases expression EXP Ouabain results in decreased expression of GRB2 protein CTD PMID:28795476 NCBI chr17:75,318,076...75,405,678
Ensembl chr17:75,318,076...75,405,709
JBrowse link
G GTPBP6 GTP binding protein 6 (putative) increases expression EXP Ouabain results in increased expression of GTPBP6 mRNA CTD PMID:16412265 NCBI chr  X:304,759...318,796
NCBI chr  Y:304,759...318,796
Ensembl chr  X:304,529...318,796
JBrowse link
G H2AX H2A.X variant histone increases phosphorylation EXP Ouabain results in increased phosphorylation of H2AX protein CTD PMID:31436044 NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465
JBrowse link
G HEY1 hes related family bHLH transcription factor with YRPW motif 1 increases expression EXP Ouabain results in increased expression of HEY1 mRNA CTD PMID:28795476 NCBI chr 8:79,764,010...79,767,767
Ensembl chr 8:79,762,371...79,767,857
JBrowse link
G HGF hepatocyte growth factor multiple interactions ISO Ouabain inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide] CTD PMID:18031729 NCBI chr 7:81,699,010...81,770,047
Ensembl chr 7:81,699,010...81,770,438
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions
increases activity
affects localization
EXP 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain affects the localization of HIF1A protein]; 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain results in increased phosphorylation of HIF1A protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Ouabain affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Ouabain results in increased phosphorylation of HIF1A protein]; Ouabain results in increased phosphorylation of and results in increased expression of HIF1A protein
Ouabain results in increased activity of HIF1A protein
CTD PMID:19647009 NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 affects expression EXP Ouabain affects the expression of HNRNPA2B1 protein CTD PMID:17268060 NCBI chr 7:26,189,927...26,200,746
Ensembl chr 7:26,171,151...26,201,529
JBrowse link
G HNRNPDL heterogeneous nuclear ribonucleoprotein D like decreases expression EXP Ouabain results in decreased expression of HNRNPDL mRNA CTD PMID:16412265 NCBI chr 4:82,422,564...82,430,462
Ensembl chr 4:82,422,565...82,430,462
JBrowse link
G HPCAL1 hippocalcin like 1 affects expression EXP Ouabain affects the expression of HPCAL1 protein CTD PMID:17268060 NCBI chr 2:10,302,904...10,427,604
Ensembl chr 2:10,302,889...10,427,617
JBrowse link
G HRG histidine rich glycoprotein affects expression EXP Ouabain affects the expression of HRG protein CTD PMID:17268060 NCBI chr 3:186,666,014...186,678,234
Ensembl chr 3:186,660,216...186,678,234
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Ouabain results in increased expression of HSPA5 protein CTD PMID:31436044 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382
JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 affects expression
multiple interactions
EXP Ouabain affects the expression of HSPD1 protein
Ouabain inhibits the reaction [HSPD1 protein binds to BAX protein]; Ouabain results in decreased expression of and affects the localization of HSPD1 protein
CTD PMID:17268060 PMID:18247327 NCBI chr 2:197,486,584...197,500,274
Ensembl chr 2:197,486,584...197,516,737
JBrowse link
G ID2 inhibitor of DNA binding 2 increases expression EXP Ouabain results in increased expression of ID2 mRNA CTD PMID:28795476 NCBI chr 2:8,682,056...8,684,461
Ensembl chr 2:8,678,845...8,684,461
JBrowse link
G IL2RA interleukin 2 receptor subunit alpha decreases expression EXP Ouabain results in decreased expression of IL2RA mRNA CTD PMID:7593202 NCBI chr10:6,010,689...6,062,367
Ensembl chr10:6,010,689...6,062,370
JBrowse link
G IL2RB interleukin 2 receptor subunit beta decreases expression EXP Ouabain results in decreased expression of IL2RB CTD PMID:7593202 NCBI chr22:37,125,838...37,175,118
Ensembl chr22:37,118,666...37,175,118
JBrowse link
G IL6 interleukin 6 increases secretion
increases expression
EXP Ouabain results in increased secretion of IL6 protein
Ouabain results in increased expression of IL6 mRNA
CTD PMID:33760381 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G IL6R interleukin 6 receptor increases expression EXP Ouabain results in increased expression of IL6R mRNA CTD PMID:33760381 NCBI chr 1:154,405,343...154,469,450
Ensembl chr 1:154,405,193...154,469,450
JBrowse link
G ILK integrin linked kinase decreases expression EXP Ouabain results in decreased expression of ILK mRNA CTD PMID:28795476 NCBI chr11:6,603,774...6,610,870
Ensembl chr11:6,603,708...6,610,874
JBrowse link
G ITGAV integrin subunit alpha V decreases expression EXP Ouabain results in decreased expression of ITGAV mRNA CTD PMID:28795476 NCBI chr 2:186,590,056...186,680,901
Ensembl chr 2:186,590,010...186,680,901
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit decreases expression
decreases phosphorylation
EXP Ouabain results in decreased expression of JUN mRNA
Ouabain results in decreased phosphorylation of JUN protein
CTD PMID:28795476 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
JBrowse link
G KCND2 potassium voltage-gated channel subfamily D member 2 increases expression EXP
ISO
Ouabain results in increased expression of KCND2 mRNA CTD PMID:16412265 NCBI chr 7:120,272,908...120,750,337
Ensembl chr 7:120,273,175...120,750,337
JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 decreases expression
multiple interactions
decreases activity
EXP Ouabain results in decreased expression of KCNH2 protein modified form
Ouabain inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Ouabain results in decreased activity of KCNH2 protein
CTD PMID:19139152 PMID:21158687 NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321
JBrowse link
G LEF1 lymphoid enhancer binding factor 1 decreases expression EXP Ouabain results in decreased expression of LEF1 mRNA CTD PMID:28795476 NCBI chr 4:108,047,548...108,168,932
Ensembl chr 4:108,047,545...108,168,956
JBrowse link
G LGALS1 galectin 1 affects expression
increases expression
EXP Ouabain affects the expression of LGALS1 protein
Ouabain results in increased expression of LGALS1 protein
CTD PMID:17268060 PMID:18247327 NCBI chr22:37,675,636...37,679,802
Ensembl chr22:37,675,636...37,679,802
JBrowse link
G LIMK1 LIM domain kinase 1 decreases expression EXP Ouabain results in decreased expression of LIMK1 mRNA CTD PMID:28795476 NCBI chr 7:74,083,804...74,122,525
Ensembl chr 7:74,082,933...74,122,525
JBrowse link
G LSS lanosterol synthase increases abundance EXP LSS protein results in increased abundance of Ouabain CTD PMID:21106941 NCBI chr21:46,188,446...46,228,774
Ensembl chr21:46,188,141...46,228,824
JBrowse link
G MAP2K6 mitogen-activated protein kinase kinase 6 increases expression EXP Ouabain results in increased expression of MAP2K6 mRNA CTD PMID:28795476 NCBI chr17:69,414,697...69,553,865
Ensembl chr17:69,414,697...69,553,865
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
decreases phosphorylation
ISO
EXP
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased phosphorylation of MAPK1 protein]
Ouabain results in decreased phosphorylation of MAPK1 protein
CTD PMID:19687166 PMID:28795476 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
decreases phosphorylation
ISO
EXP
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased phosphorylation of MAPK3 protein]
Ouabain results in decreased phosphorylation of MAPK3 protein
CTD PMID:19687166 PMID:28795476 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK7 mitogen-activated protein kinase 7 multiple interactions EXP Ouabain inhibits the reaction [palytoxin results in increased phosphorylation of and results in increased activity of MAPK7 protein] CTD PMID:19716839 NCBI chr17:19,377,750...19,383,544
Ensembl chr17:19,377,721...19,383,544
JBrowse link
G MDH2 malate dehydrogenase 2 affects expression EXP Ouabain affects the expression of MDH2 protein CTD PMID:17268060 NCBI chr 7:76,048,106...76,067,508
Ensembl chr 7:76,048,051...76,067,508
JBrowse link
G MDM2 MDM2 proto-oncogene multiple interactions EXP Ouabain results in decreased expression of and results in decreased phosphorylation of MDM2 protein CTD PMID:31436044 NCBI chr12:68,808,172...68,850,686
Ensembl chr12:68,808,177...68,845,544
JBrowse link
G MGMT O-6-methylguanine-DNA methyltransferase decreases expression EXP Ouabain results in decreased expression of MGMT protein CTD PMID:31436044 NCBI chr10:129,467,241...129,770,983
Ensembl chr10:129,467,190...129,770,983
JBrowse link
G MIR29B1 microRNA 29b-1 multiple interactions
decreases expression
ISO MIR29B1 mRNA inhibits the reaction [Ouabain results in increased expression of COL1A1 mRNA]
Ouabain results in decreased expression of MIR29B1 mRNA
CTD PMID:26702050 NCBI chr 7:130,877,459...130,877,539
Ensembl chr 7:130,877,459...130,877,539
JBrowse link
G MMP13 matrix metallopeptidase 13 decreases expression EXP Ouabain results in decreased expression of MMP13 mRNA CTD PMID:28795476 NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732
JBrowse link
G MMP2 matrix metallopeptidase 2 decreases expression
multiple interactions
EXP Ouabain results in decreased expression of MMP2 mRNA
Ouabain results in decreased expression of and results in decreased activity of MMP2 protein
CTD PMID:28795476 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G MMP9 matrix metallopeptidase 9 decreases expression EXP Ouabain results in decreased expression of MMP9 mRNA; Ouabain results in decreased expression of MMP9 protein CTD PMID:28795476 PMID:33760381 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G MRAS muscle RAS oncogene homolog decreases expression EXP Ouabain results in decreased expression of MRAS mRNA CTD PMID:28795476 NCBI chr 3:138,347,648...138,405,535
Ensembl chr 3:138,347,648...138,405,534
JBrowse link
G MRTFA myocardin related transcription factor A decreases expression EXP Ouabain results in decreased expression of MRTFA mRNA CTD PMID:28795476 NCBI chr22:40,410,289...40,636,719
Ensembl chr22:40,410,281...40,636,719
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor decreases expression
increases expression
EXP Ouabain results in decreased expression of MYC mRNA; Ouabain results in decreased expression of MYC protein
Ouabain results in increased expression of MYC protein
CTD PMID:9653513 PMID:21215801 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G MYL12A myosin light chain 12A increases expression EXP Ouabain results in increased expression of MYL12A protein CTD PMID:17268060 NCBI chr18:3,247,482...3,256,237
Ensembl chr18:3,247,481...3,256,236
JBrowse link
G MYLK myosin light chain kinase decreases expression EXP Ouabain results in decreased expression of MYLK mRNA CTD PMID:28795476 NCBI chr 3:123,610,049...123,884,332
Ensembl chr 3:123,610,049...123,884,332
JBrowse link
G NECTIN3 nectin cell adhesion molecule 3 decreases expression EXP Ouabain results in decreased expression of NECTIN3 mRNA CTD PMID:28795476 NCBI chr 3:111,071,816...111,194,170
Ensembl chr 3:111,070,071...111,275,563
JBrowse link
G NECTIN4 nectin cell adhesion molecule 4 increases expression EXP Ouabain results in increased expression of NECTIN4 mRNA CTD PMID:28795476 NCBI chr 1:161,070,998...161,089,558
Ensembl chr 1:161,070,998...161,089,558
JBrowse link
G NEFL neurofilament light chain decreases expression EXP Ouabain results in decreased expression of NEFL mRNA CTD PMID:28795476 NCBI chr 8:24,950,955...24,956,612
Ensembl chr 8:24,950,955...24,956,721
JBrowse link
G NOS1 nitric oxide synthase 1 affects expression
increases expression
ISO Ouabain affects the expression of NOS1 protein
Ouabain results in increased expression of NOS1 protein
CTD PMID:12384489 PMID:15097235 NCBI chr12:117,208,142...117,361,626
Ensembl chr12:117,208,142...117,452,170
JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions
increases expression
affects expression
ISO 5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide inhibits the reaction [Ouabain results in increased expression of NOS3 protein]
Ouabain affects the expression of NOS3 protein
CTD PMID:12384489 PMID:15477225 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
JBrowse link
G NPC2 NPC intracellular cholesterol transporter 2 decreases expression EXP Ouabain results in decreased expression of NPC2 mRNA CTD PMID:16412265 NCBI chr14:74,479,935...74,493,512
Ensembl chr14:74,476,192...74,494,177
JBrowse link
G NPPA natriuretic peptide A increases expression
multiple interactions
ISO Ouabain results in increased expression of NPPA mRNA
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased expression of NPPA mRNA]; Ouabain promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]
CTD PMID:17266992 PMID:19687166 NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345
JBrowse link
G NRAS NRAS proto-oncogene, GTPase decreases expression EXP Ouabain results in decreased expression of NRAS mRNA CTD PMID:28795476 NCBI chr 1:114,704,469...114,716,771
Ensembl chr 1:114,704,469...114,716,771
JBrowse link
G PARK7 Parkinsonism associated deglycase affects response to substance ISO PARK7 affects the susceptibility to Ouabain CTD PMID:16624565 NCBI chr 1:7,961,711...7,985,505
Ensembl chr 1:7,954,291...7,985,505
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions
increases cleavage
EXP Mitomycin promotes the reaction [Ouabain results in increased cleavage of PARP1 protein]; Ouabain promotes the reaction [Mitomycin results in increased cleavage of PARP1 protein] CTD PMID:24124520 PMID:31436044 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154
JBrowse link
G PCNA proliferating cell nuclear antigen decreases expression EXP Ouabain results in decreased expression of PCNA mRNA; Ouabain results in decreased expression of PCNA protein CTD PMID:20460749 PMID:21215801 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
JBrowse link
G PDCD6 programmed cell death 6 increases expression EXP Ouabain results in increased expression of PDCD6 protein CTD PMID:18247327 NCBI chr 5:271,646...314,974
Ensembl chr 5:271,621...314,974
JBrowse link
G PFDN5 prefoldin subunit 5 affects expression EXP Ouabain affects the expression of PFDN5 protein CTD PMID:17268060 NCBI chr12:53,295,542...53,299,450
Ensembl chr12:53,295,291...53,299,452
JBrowse link
G PFN1 profilin 1 affects expression
decreases expression
EXP Ouabain affects the expression of PFN1 protein
Ouabain results in decreased expression of PFN1 protein
CTD PMID:17268060 PMID:18247327 NCBI chr17:4,945,652...4,948,530
Ensembl chr17:4,945,652...4,949,061
JBrowse link
G PLAUR plasminogen activator, urokinase receptor decreases expression EXP Ouabain results in decreased expression of PLAUR mRNA CTD PMID:28795476 NCBI chr19:43,646,095...43,670,169
Ensembl chr19:43,646,095...43,670,547
JBrowse link
G PLCG1 phospholipase C gamma 1 decreases expression EXP Ouabain results in decreased expression of PLCG1 mRNA CTD PMID:28795476 NCBI chr20:41,137,543...41,177,626
Ensembl chr20:41,136,960...41,196,801
JBrowse link
G PPT2 palmitoyl-protein thioesterase 2 decreases expression EXP Ouabain results in decreased expression of PPT2 mRNA CTD PMID:16412265 NCBI chr 6:32,153,528...32,163,675
Ensembl chr 6:32,153,441...32,163,678
JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit decreases expression EXP Ouabain results in decreased expression of PRKDC protein CTD PMID:31436044 NCBI chr 8:47,773,111...47,960,136
Ensembl chr 8:47,773,111...47,960,178
JBrowse link
G PSMB6 proteasome 20S subunit beta 6 affects expression EXP Ouabain affects the expression of PSMB6 protein CTD PMID:17268060 NCBI chr17:4,796,164...4,798,495
Ensembl chr17:4,796,144...4,798,502
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO [Ouabain results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Nitric Oxide CTD PMID:18976649 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 decreases expression EXP Ouabain results in decreased expression of PTPN2 mRNA CTD PMID:16412265 NCBI chr18:12,785,478...12,884,237
Ensembl chr18:12,785,478...12,929,643
JBrowse link
G RAB11B RAB11B, member RAS oncogene family increases expression EXP Ouabain results in increased expression of RAB11B protein CTD PMID:18247327 NCBI chr19:8,390,360...8,404,434
Ensembl chr19:8,389,981...8,404,434
JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase decreases expression EXP Ouabain results in decreased expression of RAF1 mRNA CTD PMID:28795476 NCBI chr 3:12,583,601...12,664,117
Ensembl chr 3:12,582,101...12,664,201
JBrowse link
G RASGRF1 Ras protein specific guanine nucleotide releasing factor 1 decreases expression EXP Ouabain results in decreased expression of RASGRF1 mRNA CTD PMID:28795476 NCBI chr15:78,959,906...79,090,780
Ensembl chr15:78,959,906...79,090,780
JBrowse link
G RGS2 regulator of G protein signaling 2 decreases expression EXP Ouabain results in decreased expression of RGS2 mRNA CTD PMID:28795476 NCBI chr 1:192,809,039...192,812,275
Ensembl chr 1:192,809,039...192,812,275
JBrowse link
G RHOH ras homolog family member H increases expression EXP Ouabain results in increased expression of RHOH mRNA CTD PMID:28795476 NCBI chr 4:40,191,080...40,246,967
Ensembl chr 4:40,191,011...40,246,967
JBrowse link
G ROCK1 Rho associated coiled-coil containing protein kinase 1 increases cleavage
multiple interactions
EXP Ouabain results in increased cleavage of ROCK1 protein
benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Ouabain results in increased cleavage of ROCK1 protein]
CTD PMID:20661774 NCBI chr18:20,946,906...21,111,813
Ensembl chr18:20,946,906...21,111,813
JBrowse link
G ROCK2 Rho associated coiled-coil containing protein kinase 2 multiple interactions
increases cleavage
EXP benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Ouabain results in increased cleavage of ROCK2 protein] CTD PMID:20661774 NCBI chr 2:11,179,759...11,345,437
Ensembl chr 2:11,179,759...11,348,330
JBrowse link
G RPA3 replication protein A3 affects expression EXP Ouabain affects the expression of RPA3 protein CTD PMID:17268060 NCBI chr 7:7,636,518...7,718,607
Ensembl chr 7:7,636,518...7,718,607
JBrowse link
G RPGRIP1L RPGRIP1 like decreases expression EXP Ouabain results in decreased expression of RPGRIP1L mRNA CTD PMID:16412265 NCBI chr16:53,598,153...53,703,859
Ensembl chr16:53,598,153...53,703,938
JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 affects expression ISO Ouabain affects the expression of RPS6KB1 mRNA CTD PMID:28099878 NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574
JBrowse link
G RYR2 ryanodine receptor 2 multiple interactions
increases response to substance
ISO K201 compound inhibits the reaction [RYR2 mutant form results in increased susceptibility to Ouabain] CTD PMID:20080988 NCBI chr 1:237,042,184...237,833,988
Ensembl chr 1:237,042,184...237,833,988
JBrowse link
G S100A13 S100 calcium binding protein A13 affects expression EXP Ouabain affects the expression of S100A13 protein CTD PMID:17268060 NCBI chr 1:153,618,799...153,634,361
Ensembl chr 1:153,618,787...153,631,360
JBrowse link
G S100B S100 calcium binding protein B increases expression ISO Ouabain results in increased expression of S100B protein CTD PMID:15581912 NCBI chr21:46,598,604...46,605,082
Ensembl chr21:46,598,604...46,605,208
JBrowse link
G SGK1 serum/glucocorticoid regulated kinase 1 multiple interactions
decreases expression
EXP Ouabain inhibits the reaction [SGK1 protein results in increased transport of Potassium]
Ouabain results in decreased expression of SGK1 mRNA
CTD PMID:12590200 PMID:28795476 NCBI chr 6:134,169,256...134,318,112
Ensembl chr 6:134,169,248...134,318,112
JBrowse link
G SGK2 serum/glucocorticoid regulated kinase 2 multiple interactions EXP Ouabain inhibits the reaction [SGK2 protein results in increased transport of Potassium] CTD PMID:12590200 NCBI chr20:43,559,027...43,585,627
Ensembl chr20:43,558,968...43,588,237
JBrowse link
G SGK3 serum/glucocorticoid regulated kinase family member 3 multiple interactions EXP Ouabain inhibits the reaction [SGK3 protein results in increased transport of Potassium] CTD PMID:12590200 NCBI chr 8:66,712,781...66,862,022
Ensembl chr 8:66,712,734...66,862,022
JBrowse link
G SHC3 SHC adaptor protein 3 increases expression EXP Ouabain results in increased expression of SHC3 mRNA CTD PMID:28795476 NCBI chr 9:89,005,771...89,178,818
Ensembl chr 9:89,005,771...89,178,818
JBrowse link
G SLC16A1 solute carrier family 16 member 1 multiple interactions EXP Ouabain inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid] CTD PMID:15804185 NCBI chr 1:112,911,847...112,956,196
Ensembl chr 1:112,911,847...112,957,593
JBrowse link
G SLC22A12 solute carrier family 22 member 12 multiple interactions ISO Ouabain promotes the reaction [SLC22A12 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:15284287 NCBI chr11:64,591,220...64,602,344
Ensembl chr11:64,590,641...64,602,353
JBrowse link
G SLC5A5 solute carrier family 5 member 5 multiple interactions EXP Ouabain inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide] CTD PMID:12541134 NCBI chr19:17,871,945...17,895,174
Ensembl chr19:17,871,945...17,895,174
JBrowse link
G SLC5A6 solute carrier family 5 member 6 multiple interactions EXP Ouabain inhibits the reaction [SLC5A6 protein results in increased transport of Biotin] CTD PMID:15561972 NCBI chr 2:27,199,587...27,212,787
Ensembl chr 2:27,199,587...27,212,958
JBrowse link
G SLC8A1 solute carrier family 8 member A1 affects response to substance
multiple interactions
increases expression
ISO SLC8A1 affects the susceptibility to Ouabain
SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]; SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]
CTD PMID:16166162 PMID:19897708 NCBI chr 2:40,097,270...40,512,435
Ensembl chr 2:40,097,270...40,611,053
JBrowse link
G SLC9A1 solute carrier family 9 member A1 multiple interactions
increases expression
ISO N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased expression of SLC9A1 mRNA] CTD PMID:19687166 NCBI chr 1:27,098,809...27,155,125
Ensembl chr 1:27,098,809...27,166,981
JBrowse link
G SMAD4 SMAD family member 4 decreases expression EXP Ouabain results in decreased expression of SMAD4 mRNA CTD PMID:28795476 NCBI chr18:51,030,213...51,085,042
Ensembl chr18:51,028,394...51,085,045
JBrowse link
G SNAI1 snail family transcriptional repressor 1 decreases expression EXP Ouabain results in decreased expression of SNAI1 mRNA CTD PMID:33760381 NCBI chr20:49,982,980...49,988,886
Ensembl chr20:49,982,980...49,988,886
JBrowse link
G SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1 decreases expression EXP Ouabain results in decreased expression of SOS1 protein CTD PMID:28795476 NCBI chr 2:38,981,549...39,124,868
Ensembl chr 2:38,962,206...39,124,345
JBrowse link
G SOS2 SOS Ras/Rho guanine nucleotide exchange factor 2 decreases expression EXP Ouabain results in decreased expression of SOS2 mRNA CTD PMID:28795476 NCBI chr14:50,117,130...50,231,882
Ensembl chr14:50,117,130...50,231,578
JBrowse link
G SPHK1 sphingosine kinase 1 decreases expression EXP Ouabain results in decreased expression of SPHK1 mRNA CTD PMID:28795476 NCBI chr17:76,383,204...76,387,855
Ensembl chr17:76,376,584...76,387,860
JBrowse link
G TGFB1 transforming growth factor beta 1 decreases expression EXP Ouabain results in decreased expression of TGFB1 mRNA CTD PMID:28795476 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TGFB2 transforming growth factor beta 2 decreases expression EXP Ouabain results in decreased expression of TGFB2 mRNA CTD PMID:28795476 NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619
JBrowse link
G TGFB3 transforming growth factor beta 3 decreases expression EXP Ouabain results in decreased expression of TGFB3 mRNA CTD PMID:28795476 NCBI chr14:75,958,097...75,983,011
Ensembl chr14:75,958,097...75,983,011
JBrowse link
G TGFBR3 transforming growth factor beta receptor 3 increases expression EXP Ouabain results in increased expression of TGFBR3 mRNA CTD PMID:28795476 NCBI chr 1:91,680,343...91,906,002
Ensembl chr 1:91,680,343...91,906,335
JBrowse link
G TLN1 talin 1 decreases expression EXP Ouabain results in decreased expression of TLN1 mRNA CTD PMID:28795476 NCBI chr 9:35,696,948...35,732,195
Ensembl chr 9:35,696,948...35,732,195
JBrowse link
G TLN2 talin 2 decreases expression EXP Ouabain results in decreased expression of TLN2 mRNA CTD PMID:28795476 NCBI chr15:62,390,550...62,844,631
Ensembl chr15:62,390,526...62,844,631
JBrowse link
G TNFRSF10A TNF receptor superfamily member 10a increases expression EXP Ouabain results in increased expression of TNFRSF10A protein CTD PMID:31436044 NCBI chr 8:23,190,452...23,225,102
Ensembl chr 8:23,190,452...23,225,102
JBrowse link
G TNFRSF10B TNF receptor superfamily member 10b increases expression EXP Ouabain results in increased expression of TNFRSF10B protein CTD PMID:31436044 NCBI chr 8:23,020,133...23,069,031
Ensembl chr 8:23,020,133...23,069,031
JBrowse link
G TP53 tumor protein p53 multiple interactions EXP Ouabain results in decreased expression of and results in increased phosphorylation of TP53 protein CTD PMID:31436044 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TPI1 triosephosphate isomerase 1 affects expression EXP Ouabain affects the expression of TPI1 protein CTD PMID:17268060 NCBI chr12:6,867,420...6,870,948
Ensembl chr12:6,867,119...6,870,948
JBrowse link
G TPT1 tumor protein, translationally-controlled 1 affects expression EXP Ouabain affects the expression of TPT1 protein CTD PMID:17268060 NCBI chr13:45,333,471...45,341,183
Ensembl chr13:45,333,471...45,341,284
JBrowse link
G TRIM63 tripartite motif containing 63 multiple interactions ISO [Ouabain co-treated with Botulinum Toxins, Type A] affects the expression of TRIM63 mRNA CTD PMID:21139329 NCBI chr 1:26,051,301...26,067,630
Ensembl chr 1:26,051,301...26,068,436
JBrowse link
G TRPC1 transient receptor potential cation channel subfamily C member 1 increases expression ISO Ouabain results in increased expression of TRPC1 protein CTD PMID:19897708 NCBI chr 3:142,724,034...142,807,888
Ensembl chr 3:142,724,034...142,807,888
JBrowse link
G TRPC6 transient receptor potential cation channel subfamily C member 6 increases expression
multiple interactions
ISO Ouabain results in increased expression of TRPC6 protein
SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]
CTD PMID:19897708 NCBI chr11:101,451,564...101,584,007
Ensembl chr11:101,451,564...101,872,562
JBrowse link
G TWIST1 twist family bHLH transcription factor 1 increases expression EXP Ouabain results in increased expression of TWIST1 mRNA CTD PMID:33760381 NCBI chr 7:19,113,047...19,117,636
Ensembl chr 7:19,020,991...19,117,636
JBrowse link
G TXN thioredoxin affects expression EXP Ouabain affects the expression of TXN protein CTD PMID:17268060 NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507
JBrowse link
G VIM vimentin decreases expression EXP Ouabain results in decreased expression of VIM mRNA CTD PMID:33760381 NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593
JBrowse link
G ZFHX3 zinc finger homeobox 3 decreases expression EXP Ouabain results in decreased expression of ZFHX3 mRNA CTD PMID:16412265 NCBI chr16:72,782,885...73,891,930
Ensembl chr16:72,782,885...73,891,871
JBrowse link
strophanthidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases transport EXP ABCB1 protein results in increased transport of Strophanthidin CTD PMID:26708294 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G G6PC1 glucose-6-phosphatase catalytic subunit 1 increases expression
multiple interactions
EXP Strophanthidin results in increased expression of G6PC1 mRNA
Strophanthidin promotes the reaction [RORC protein binds to G6PC1 promoter]
CTD PMID:29981919 NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438
JBrowse link
G IL17A interleukin 17A multiple interactions EXP Strophanthidin results in increased expression of and results in increased secretion of IL17A protein CTD PMID:29981919 NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638
JBrowse link
G IL17F interleukin 17F multiple interactions EXP Strophanthidin results in increased expression of and results in increased secretion of IL17F protein CTD PMID:29981919 NCBI chr 6:52,236,681...52,245,689
Ensembl chr 6:52,236,681...52,245,689
JBrowse link
G NPAS2 neuronal PAS domain protein 2 increases expression
multiple interactions
EXP Strophanthidin results in increased expression of NPAS2 mRNA
Strophanthidin promotes the reaction [RORC protein binds to NPAS2 promoter]
CTD PMID:29981919 NCBI chr 2:100,818,723...100,996,829
Ensembl chr 2:100,820,139...100,996,829
JBrowse link
G RORC RAR related orphan receptor C increases expression
multiple interactions
EXP Strophanthidin results in increased expression of RORC mRNA
RORC protein promotes the reaction [Strophanthidin results in increased expression of RORC mRNA]; Strophanthidin promotes the reaction [RORC protein binds to G6PC1 promoter]; Strophanthidin promotes the reaction [RORC protein binds to NPAS2 promoter]
CTD PMID:29981919 NCBI chr 1:151,806,071...151,831,802
Ensembl chr 1:151,806,071...151,831,845
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 25458
    chemical entity 25438
      molecular entity 25409
        polyatomic entity 25304
          heteroatomic molecular entity 24929
            hydroxides 23364
              organic hydroxy compound 21619
                hydroxy steroid 15185
                  5-hydroxy steroid 208
                    5alpha-hydroxy steroid + 0
                    5beta-hydroxy steroid + 208
Path 2
Term Annotations click to browse term
  CHEBI ontology 25458
    subatomic particle 25427
      composite particle 25433
        hadron 25427
          baryon 25427
            nucleon 25427
              atomic nucleus 25427
                atom 25427
                  main group element atom 25279
                    p-block element atom 25279
                      carbon group element atom 24839
                        carbon atom 24821
                          organic molecular entity 24815
                            organic molecule 24670
                              organic cyclic compound 24012
                                organic polycyclic compound 18713
                                  steroid 15537
                                    hydroxy steroid 15185
                                      5-hydroxy steroid 208
                                        5alpha-hydroxy steroid + 0
                                        5beta-hydroxy steroid + 208
paths to the root