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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:oxime O-ether
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Accession:CHEBI:36816 term browser browse the term
Definition:O-organyl oximes R2C=NOR' (R' =/= H).
Synonyms:related_synonym: Formula=CNOR3;   O-substituted oximes;   SMILES=[*]O\\N=C(/[*])[*];   oxime O-ethers;   oxime ether;   oxime ethers


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cefepime term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgap45 Rho GTPase activating protein 45 affects expression ISO cefepime affects the expression of ARHGAP45 mRNA CTD PMID:25811541 NCBI chr 7:12,541,032...12,741,314
Ensembl chr 7:12,541,061...12,741,296
JBrowse link
G Cat catalase multiple interactions ISO cefepime inhibits the reaction [Amikacin results in decreased activity of CAT protein] CTD PMID:18781908 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Dhfr dihydrofolate reductase decreases activity ISO cefepime results in decreased activity of DHFR protein CTD PMID:25418905 NCBI chr 2:21,931,887...21,958,927
Ensembl chr 2:21,931,493...21,962,453
JBrowse link
G Pgd phosphogluconate dehydrogenase decreases activity EXP cefepime results in decreased activity of PGD protein CTD PMID:15558954 NCBI chr 5:165,966,128...165,982,327 JBrowse link
G RT1-Db1 RT1 class II, locus Db1 affects expression ISO cefepime affects the expression of HLA-DRB1 mRNA CTD PMID:25811541 NCBI chr20:4,087,621...4,097,190
Ensembl chr20:4,087,618...4,097,190
JBrowse link
cefotaxime term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Cefotaxime results in increased expression of BAX protein CTD PMID:15012731 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Cefotaxime inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein] CTD PMID:16939481 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Pgd phosphogluconate dehydrogenase decreases activity EXP Cefotaxime results in decreased activity of PGD protein CTD PMID:15558954 NCBI chr 5:165,966,128...165,982,327 JBrowse link
G RT1-CE5 RT1 class I, locus CE5 affects expression ISO Cefotaxime affects the expression of HLA-F mRNA CTD PMID:25811541 NCBI chr20:4,892,702...4,896,993
Ensembl chr20:4,892,702...4,896,991
JBrowse link
G Tp53 tumor protein p53 increases expression ISO Cefotaxime results in increased expression of TP53 protein CTD PMID:15012731 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
ceftazidime pentahydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 increases transport ISO ABCC4 protein results in increased transport of Ceftazidime CTD PMID:17939016 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Dhfr dihydrofolate reductase decreases activity ISO Ceftazidime results in decreased activity of DHFR protein CTD PMID:25418905 NCBI chr 2:21,931,887...21,958,927
Ensembl chr 2:21,931,493...21,962,453
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Ceftazidime inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein] CTD PMID:16939481 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
ceftriaxone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin I converting enzyme 2 decreases expression EXP Ceftriaxone results in decreased expression of ACE2 mRNA CTD PMID:29745864 NCBI chr  X:32,050,734...32,095,860
Ensembl chr  X:32,049,931...32,096,016
JBrowse link
G Actb actin, beta increases expression EXP Ceftriaxone results in increased expression of ACTB mRNA CTD PMID:29745864 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Bace1 beta-secretase 1 decreases expression EXP Ceftriaxone results in decreased expression of BACE1 mRNA CTD PMID:29745864 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361
JBrowse link
G Cat catalase decreases expression
multiple interactions
ISO
EXP
Ceftriaxone results in decreased expression of CAT protein
Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased activity of CAT protein]; ropinirole promotes the reaction [Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased activity of CAT protein]]
CTD PMID:19442074, PMID:25053526 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Dhfr dihydrofolate reductase decreases activity ISO Ceftriaxone results in decreased activity of DHFR protein CTD PMID:25418905 NCBI chr 2:21,931,887...21,958,927
Ensembl chr 2:21,931,493...21,962,453
JBrowse link
G Ece1 endothelin converting enzyme 1 increases expression EXP Ceftriaxone results in increased expression of ECE1 mRNA CTD PMID:29745864 NCBI chr 5:156,215,469...156,318,652
Ensembl chr 5:156,215,417...156,318,671
JBrowse link
G Epo erythropoietin increases expression EXP Ceftriaxone results in increased expression of EPO mRNA CTD PMID:29745864 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Ide insulin degrading enzyme increases expression EXP Ceftriaxone results in increased expression of IDE mRNA CTD PMID:29745864 NCBI chr 1:255,914,465...256,014,168
Ensembl chr 1:255,914,447...256,013,495
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B protein]; ropinirole promotes the reaction [Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B protein]] CTD PMID:25053526 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Mme membrane metallo-endopeptidase increases expression EXP Ceftriaxone results in increased expression of MME mRNA CTD PMID:29745864 NCBI chr 2:153,799,203...153,880,910
Ensembl chr 2:153,803,349...153,880,738
JBrowse link
G Slc1a2 solute carrier family 1 member 2 multiple interactions
increases expression
EXP Ceftriaxone inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of SLC1A2 protein]; Ceftriaxone inhibits the reaction [Cocaine results in decreased expression of SLC1A2 protein]; Ceftriaxone promotes the reaction [Kainic Acid results in increased expression of SLC1A2 protein]
Ceftriaxone results in increased expression of SLC1A2 protein
CTD PMID:19625514, PMID:19717140, PMID:28257918, PMID:29045497 NCBI chr 3:92,518,679...92,665,731
Ensembl chr 3:92,640,752...92,665,644
JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions EXP Ceftriaxone inhibits the reaction [Cocaine results in decreased expression of SLC7A11 protein] CTD PMID:19717140 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF protein]; ropinirole promotes the reaction [Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF protein]] CTD PMID:25053526 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
cefuroxime term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases activity EXP Cefuroxime results in decreased activity of CAT protein CTD PMID:30797828 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Cefuroxime inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein] CTD PMID:16939481 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases activity ISO Cefuroxime results in decreased activity of NFE2L2 protein CTD PMID:30203046 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 decreases activity ISO Cefuroxime results in decreased activity of NR1I3 protein CTD PMID:30203046 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases activity ISO Cefuroxime results in decreased activity of PPARA protein CTD PMID:30203046 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G RT1-Bb RT1 class II, locus Bb affects expression ISO Cefuroxime affects the expression of HLA-DQB1 mRNA CTD PMID:25811541 NCBI chr20:4,043,726...4,049,367
Ensembl chr20:4,039,413...4,049,711
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 affects expression ISO Cefuroxime affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr20:3,176,124...3,180,825
Ensembl chr20:3,176,107...3,179,818
JBrowse link
fluoxastrobin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO fluoxastrobin inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:30818834 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO fluoxastrobin inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:30818834 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO fluoxastrobin inhibits the reaction [Estradiol results in increased activity of ESR2 protein] CTD PMID:30818834 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions ISO fluoxastrobin inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein]; fluoxastrobin inhibits the reaction [XCT790 results in decreased activity of ESRRA protein] CTD PMID:30818834 NCBI chr 1:222,168,729...222,178,842
Ensembl chr 1:222,168,730...222,178,725
JBrowse link
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha decreases expression ISO fluoxastrobin results in decreased expression of IDH3A mRNA CTD PMID:30818834 NCBI chr 8:59,164,601...59,183,899
Ensembl chr 8:59,164,572...59,183,908
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity ISO fluoxastrobin results in increased activity of NFE2L2 protein CTD PMID:30818834 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO fluoxastrobin inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein] CTD PMID:30818834 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Pgr progesterone receptor multiple interactions ISO fluoxastrobin inhibits the reaction [Promegestone results in increased activity of PGR protein] CTD PMID:30818834 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO fluoxastrobin inhibits the reaction [Rosiglitazone results in increased activity of PPARG protein] CTD PMID:30818834 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO fluoxastrobin inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein] CTD PMID:30818834 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
fluvoxamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO Fluvoxamine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Fluvoxamine results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance ISO ABCB1A protein affects the susceptibility to Fluvoxamine CTD PMID:15502009 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Fluvoxamine CTD PMID:15502009 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Fluvoxamine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Avp arginine vasopressin increases expression ISO Fluvoxamine results in increased expression of AVP protein CTD PMID:11195401 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO Fluvoxamine results in increased activity of CASP3 protein
Palmitic Acid promotes the reaction [Fluvoxamine results in increased activity of CASP3 protein]
CTD PMID:22700542 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions
ISO Fluvoxamine results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Fluvoxamine results in increased activity of CASP7 protein]
CTD PMID:22700542 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO Fluvoxamine results in decreased activity of CYP19A1 protein CTD PMID:26162595 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
increases response to substance
ISO
EXP
[Fluvoxamine results in decreased activity of CYP1A2 protein] which results in decreased chemical synthesis of 16-O-demethylaconitine metabolite; [Fluvoxamine results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; [Fluvoxamine results in decreased activity of CYP1A2 protein] which results in increased chemical synthesis of Aconitine metabolite; CYP1A2 protein binds to and affects the metabolism of Fluvoxamine; Enoxacin inhibits the reaction [CYP1A2 protein affects the metabolism of Fluvoxamine]; Fluvoxamine inhibits the reaction [CYP1A2 protein affects the metabolism of olanzapine]; Fluvoxamine inhibits the reaction [CYP1A2 protein affects the metabolism of Theophylline]; Fluvoxamine inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of Acetaminophen]; Fluvoxamine inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of clozapine N-oxide]; Fluvoxamine inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of norclozapine]; Fluvoxamine inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]
[Fluvoxamine results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Caffeine
CYP1A2 protein results in increased susceptibility to Fluvoxamine
CTD PMID:9029748, PMID:11763009, PMID:15545309, PMID:15845683, PMID:15905806, PMID:18809730, PMID:18816299, PMID:21277363, PMID:21915887, PMID:26599973 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO Fluvoxamine inhibits the reaction [CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidol] CTD PMID:12584149 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Gad1 glutamate decarboxylase 1 multiple interactions EXP [Haloperidol co-treated with Fluvoxamine] affects the expression of GAD1 protein CTD PMID:15967061 NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A affects response to substance ISO HTR2A gene SNP affects the susceptibility to Fluvoxamine CTD PMID:12607287 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO
EXP
Fluvoxamine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of ICAM1 mRNA]
Fluvoxamine inhibits the reaction [Carrageenan results in increased expression of ICAM1 mRNA]
CTD PMID:27803785 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
ISO [Terfenadine co-treated with Fluvoxamine] binds to and results in decreased activity of KCNH2 protein; Fluvoxamine binds to and results in decreased activity of KCNH2 protein; Fluvoxamine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Fluvoxamine results in decreased activity of KCNH2 protein
CTD PMID:20071423, PMID:21158687, PMID:24052561 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
EXP
ISO
Fluvoxamine results in increased expression of NOS2 mRNA
Fluvoxamine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]
Fluvoxamine inhibits the reaction [Carrageenan results in increased expression of NOS2 mRNA]
CTD PMID:12429386, PMID:27803785 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Prkcb protein kinase C, beta multiple interactions EXP [Haloperidol co-treated with Fluvoxamine] affects the expression of PRKCB protein CTD PMID:15967061 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP
ISO
Fluvoxamine inhibits the reaction [Carrageenan results in increased expression of PTGS2 mRNA]
Fluvoxamine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 mRNA]
CTD PMID:27803785 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 decreases activity
affects response to substance
ISO Fluvoxamine results in decreased activity of SCN5A protein
SCN5A protein affects the susceptibility to Fluvoxamine
CTD PMID:19875396 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP
ISO
Fluvoxamine inhibits the reaction [Carrageenan results in increased expression of VCAM1 mRNA]
Fluvoxamine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of VCAM1 mRNA]
CTD PMID:27803785 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
kresoxim-methyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr2 estrogen receptor 2 multiple interactions ISO kresoxim-methyl inhibits the reaction [Estradiol results in increased activity of ESR2 protein] CTD PMID:30818834 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions ISO kresoxim-methyl inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein]; kresoxim-methyl inhibits the reaction [XCT790 results in decreased activity of ESRRA protein] CTD PMID:30818834 NCBI chr 1:222,168,729...222,178,842
Ensembl chr 1:222,168,730...222,178,725
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity ISO kresoxim-methyl results in increased activity of NFE2L2 protein CTD PMID:30818834 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Pgr progesterone receptor multiple interactions ISO kresoxim-methyl inhibits the reaction [Promegestone results in increased activity of PGR protein] CTD PMID:30818834 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO kresoxim-methyl inhibits the reaction [Rosiglitazone results in increased activity of PPARG protein] CTD PMID:30818834 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO kresoxim-methyl inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein] CTD PMID:30818834 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Thrb thyroid hormone receptor beta affects binding ISO kresoxim-methyl binds to THRB protein CTD PMID:28973306 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Tp53 tumor protein p53 increases activity ISO kresoxim-methyl results in increased activity of TP53 protein CTD PMID:30818834 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
oxiconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO oxiconazole results in decreased activity of CYP19A1 protein CTD PMID:24496634 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO oxiconazole inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO oxiconazole results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO oxiconazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]; oxiconazole promotes the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Rifampin inhibits the reaction [oxiconazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]] CTD PMID:17998298 NCBI chr 6:28,677,563...28,931,844
Ensembl chr 6:28,677,540...28,931,843
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
decreases expression
decreases activity
ISO oxiconazole binds to and results in increased activity of NR1I2 protein; oxiconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]]; oxiconazole inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]; oxiconazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]; oxiconazole promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]; oxiconazole promotes the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Rifampin inhibits the reaction [oxiconazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Rifampin inhibits the reaction [oxiconazole results in increased expression of NR1I2 mRNA]
oxiconazole results in decreased expression of NR1I2 mRNA
oxiconazole results in decreased activity of NR1I2 protein
CTD PMID:17438109, PMID:17998298 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO oxiconazole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
trifloxystrobin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO trifloxystrobin inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:30818834 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Becn1 beclin 1 increases expression ISO trifloxystrobin results in increased expression of BECN1 protein CTD PMID:27853101 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Dnm1l dynamin 1-like increases phosphorylation
multiple interactions
ISO trifloxystrobin results in increased phosphorylation of DNM1L protein
MitoTEMPO inhibits the reaction [trifloxystrobin results in increased phosphorylation of DNM1L protein]
CTD PMID:27853101 NCBI chr11:88,830,968...88,882,271
Ensembl chr11:88,830,957...88,880,198
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO trifloxystrobin inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:30818834 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO trifloxystrobin inhibits the reaction [Estradiol results in increased activity of ESR2 protein] CTD PMID:30818834 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions ISO trifloxystrobin inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein]; trifloxystrobin inhibits the reaction [XCT790 results in decreased activity of ESRRA protein] CTD PMID:30818834 NCBI chr 1:222,168,729...222,178,842
Ensembl chr 1:222,168,730...222,178,725
JBrowse link
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha decreases expression ISO trifloxystrobin results in decreased expression of IDH3A mRNA CTD PMID:30818834 NCBI chr 8:59,164,601...59,183,899
Ensembl chr 8:59,164,572...59,183,908
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 increases expression ISO trifloxystrobin results in increased expression of LAMP2 protein CTD PMID:27853101 NCBI chr  X:124,722,628...124,766,079
Ensembl chr  X:124,722,628...124,766,044
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression ISO trifloxystrobin results in increased expression of MAP1LC3B protein alternative form CTD PMID:27853101 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity ISO trifloxystrobin results in increased activity of NFE2L2 protein CTD PMID:30818834 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO trifloxystrobin inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein] CTD PMID:30818834 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO trifloxystrobin results in increased activity of NR1I3 protein CTD PMID:30818834 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Pgr progesterone receptor multiple interactions ISO trifloxystrobin inhibits the reaction [Promegestone results in increased activity of PGR protein] CTD PMID:30818834 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pink1 PTEN induced kinase 1 increases expression
multiple interactions
ISO trifloxystrobin results in increased expression of PINK1 protein
MitoTEMPO inhibits the reaction [trifloxystrobin results in increased expression of PINK1 protein]
CTD PMID:27853101 NCBI chr 5:156,677,146...156,689,258
Ensembl chr 5:156,677,146...156,689,415
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO trifloxystrobin inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein] CTD PMID:30818834 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase increases expression
multiple interactions
ISO trifloxystrobin results in increased expression of PRKN protein
MitoTEMPO inhibits the reaction [trifloxystrobin results in increased expression of PRKN protein]
CTD PMID:27853101 NCBI chr 1:48,880,015...50,069,998 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    chemical entity 19816
      atom 19814
        nonmetal atom 19690
          nitrogen atom 18565
            nitrogen molecular entity 18565
              organonitrogen compound 18338
                oxime O-ether 65
                  (3E)-3-(methoxyimino)propane-1,2-diol 0
                  (3Z,6E)-3,6-bis(methoxyimino)hexane-1,2,4,5-tetrol 0
                  (E)-2-(methoxyimino)-3-methylbutanoic acid 0
                  17-hydroxyprogesterone 3-O-(carboxymethyl)oxime 0
                  17beta-estradiol 6-O-(carboxymethyl)oxime 0
                  2-(ethoxyimino)-2-ketoglutaric acid 0
                  2-methylpropanal O-methyloxime + 0
                  5-methoxyvalerophenone O-(2-aminoethyl)oxime + 19
                  Cefteram pivoxil 0
                  LY-221481 0
                  N(2)-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]-N-butyl-3,3-dimethoxyalaninamide 0
                  N(2)-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]-N-butyl-L-alaninamide 0
                  N(2)-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]-N-butyl-L-cysteinamide 0
                  N(2)-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]-N-butyl-L-serinamide 0
                  N-butyl-N(2)-[(2Z)-2-(2-furyl)-2-(methoxyimino)acetyl]-3,3-dimethoxyalaninamide 0
                  N-butyl-N(2)-[(2Z)-2-(2-furyl)-2-(methoxyimino)acetyl]-L-alaninamide 0
                  N-butyl-N(2)-[(2Z)-2-(2-furyl)-2-(methoxyimino)acetyl]-L-cysteinamide 0
                  N-butyl-N(2)-[(2Z)-2-(2-furyl)-2-(methoxyimino)acetyl]-L-serinamide 0
                  Nitrilacarb 0
                  alloxydim 0
                  cefditoren pivoxil 0
                  cefepime 5
                  cefetamet pivoxil 0
                  cefodizime 0
                  cefotaxime 5
                  ceftaroline + 0
                  ceftaroline fosamil + 0
                  ceftazidime + 3
                  ceftriaxone 13
                  cefuroxime 7
                  clethodim 0
                  cycloxydim 0
                  cyflufenamid 0
                  cymoxanil 0
                  dimoxystrobin 0
                  enoxastrobin 0
                  fenaminstrobin 0
                  fluoxastrobin 10
                  kresoxim-methyl 8
                  methoxyiminoacetamide strobilurin antifungal agent + 0
                  methyl (2-chloro-5-\{N-[(6-methylpyridin-2-yl)methoxy]ethanimidoyl\}benzyl)carbamate + 0
                  metominostrobin 0
                  orysastrobin 0
                  oxiconazole 6
                  phenyl acetimidate 0
                  picarbutrazox 0
                  profoxydim 0
                  progesterone 3-O-(carboxymethyl)oxime + 0
                  propaquizafop 0
                  pyrifenox 0
                  testosterone 3-(O-carboxymethyl)oxime + 0
                  testosterone-3-CMO-Hist + 0
                  trifloxystrobin 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon group molecular entity 19608
                          organic molecular entity 19597
                            heteroorganic entity 19184
                              organochalcogen compound 18894
                                organooxygen compound 18816
                                  ether 16076
                                    oxime O-ether 65
                                      (3E)-3-(methoxyimino)propane-1,2-diol 0
                                      (3Z,6E)-3,6-bis(methoxyimino)hexane-1,2,4,5-tetrol 0
                                      (E)-2-(methoxyimino)-3-methylbutanoic acid 0
                                      17-hydroxyprogesterone 3-O-(carboxymethyl)oxime 0
                                      17beta-estradiol 6-O-(carboxymethyl)oxime 0
                                      2-(ethoxyimino)-2-ketoglutaric acid 0
                                      2-methylpropanal O-methyloxime + 0
                                      5-methoxyvalerophenone O-(2-aminoethyl)oxime + 19
                                      Cefteram pivoxil 0
                                      LY-221481 0
                                      N(2)-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]-N-butyl-3,3-dimethoxyalaninamide 0
                                      N(2)-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]-N-butyl-L-alaninamide 0
                                      N(2)-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]-N-butyl-L-cysteinamide 0
                                      N(2)-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]-N-butyl-L-serinamide 0
                                      N-butyl-N(2)-[(2Z)-2-(2-furyl)-2-(methoxyimino)acetyl]-3,3-dimethoxyalaninamide 0
                                      N-butyl-N(2)-[(2Z)-2-(2-furyl)-2-(methoxyimino)acetyl]-L-alaninamide 0
                                      N-butyl-N(2)-[(2Z)-2-(2-furyl)-2-(methoxyimino)acetyl]-L-cysteinamide 0
                                      N-butyl-N(2)-[(2Z)-2-(2-furyl)-2-(methoxyimino)acetyl]-L-serinamide 0
                                      Nitrilacarb 0
                                      alloxydim 0
                                      cefditoren pivoxil 0
                                      cefepime 5
                                      cefetamet pivoxil 0
                                      cefodizime 0
                                      cefotaxime 5
                                      ceftaroline + 0
                                      ceftaroline fosamil + 0
                                      ceftazidime + 3
                                      ceftriaxone 13
                                      cefuroxime 7
                                      clethodim 0
                                      cycloxydim 0
                                      cyflufenamid 0
                                      cymoxanil 0
                                      dimoxystrobin 0
                                      enoxastrobin 0
                                      fenaminstrobin 0
                                      fluoxastrobin 10
                                      kresoxim-methyl 8
                                      methoxyiminoacetamide strobilurin antifungal agent + 0
                                      methyl (2-chloro-5-\{N-[(6-methylpyridin-2-yl)methoxy]ethanimidoyl\}benzyl)carbamate + 0
                                      metominostrobin 0
                                      orysastrobin 0
                                      oxiconazole 6
                                      phenyl acetimidate 0
                                      picarbutrazox 0
                                      profoxydim 0
                                      progesterone 3-O-(carboxymethyl)oxime + 0
                                      propaquizafop 0
                                      pyrifenox 0
                                      testosterone 3-(O-carboxymethyl)oxime + 0
                                      testosterone-3-CMO-Hist + 0
                                      trifloxystrobin 16
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.