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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:5-methoxyvalerophenone
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Accession:CHEBI:36814 term browser browse the term
Definition:An aromatic ketone that has formula C12H16O2.
Synonyms:exact_synonym: 5-methoxy-1-phenylpentan-1-one
 related_synonym: Formula=C12H16O2;   InChI=1S/C12H16O2/c1-14-10-6-5-9-12(13)11-7-3-2-4-8-11/h2-4,7-8H,5-6,9-10H2,1H3;   InChIKey=GMRYZTZQKPZDLK-UHFFFAOYSA-N;   SMILES=COCCCCC(=O)c1ccccc1
 xref: Beilstein:2046709

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fluvoxamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity		 ISO Fluvoxamine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Fluvoxamine results in decreased activity of ABCB11 protein		 CTD PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance ISO ABCB1A protein affects the susceptibility to Fluvoxamine CTD PMID:15502009 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Fluvoxamine CTD PMID:15502009 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Fluvoxamine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Avp arginine vasopressin increases expression ISO Fluvoxamine results in increased expression of AVP protein CTD PMID:11195401 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 ISO Fluvoxamine results in increased activity of CASP3 protein
Palmitic Acid promotes the reaction [Fluvoxamine results in increased activity of CASP3 protein]		 CTD PMID:22700542 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions		 ISO Fluvoxamine results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Fluvoxamine results in increased activity of CASP7 protein]		 CTD PMID:22700542 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO Fluvoxamine results in decreased activity of CYP19A1 protein CTD PMID:26162595 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
increases response to substance		 ISO
EXP		 [Fluvoxamine results in decreased activity of CYP1A2 protein] which results in decreased chemical synthesis of 16-O-demethylaconitine metabolite; [Fluvoxamine results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; [Fluvoxamine results in decreased activity of CYP1A2 protein] which results in increased chemical synthesis of Aconitine metabolite; CYP1A2 protein binds to and affects the metabolism of Fluvoxamine; Enoxacin inhibits the reaction [CYP1A2 protein affects the metabolism of Fluvoxamine]; Fluvoxamine inhibits the reaction [CYP1A2 protein affects the metabolism of olanzapine]; Fluvoxamine inhibits the reaction [CYP1A2 protein affects the metabolism of Theophylline]; Fluvoxamine inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of Acetaminophen]; Fluvoxamine inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of clozapine N-oxide]; Fluvoxamine inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of norclozapine]; Fluvoxamine inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]
[Fluvoxamine results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Caffeine
CYP1A2 protein results in increased susceptibility to Fluvoxamine		 CTD PMID:9029748 PMID:11763009 PMID:15545309 PMID:15845683 PMID:15905806 PMID:18809730 PMID:18816299 PMID:21277363 PMID:21915887 PMID:26599973 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 multiple interactions ISO Fluvoxamine inhibits the reaction [CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol] CTD PMID:12584149 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO Fluvoxamine inhibits the reaction [CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidol] CTD PMID:12584149 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399 		JBrowse link
G Gad1 glutamate decarboxylase 1 multiple interactions EXP [Haloperidol co-treated with Fluvoxamine] affects the expression of GAD1 protein CTD PMID:15967061 NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A affects response to substance ISO HTR2A gene SNP affects the susceptibility to Fluvoxamine CTD PMID:12607287 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO
EXP		 Fluvoxamine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of ICAM1 mRNA]
Fluvoxamine inhibits the reaction [Carrageenan results in increased expression of ICAM1 mRNA]		 CTD PMID:27803785 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity		 ISO [Terfenadine co-treated with Fluvoxamine] binds to and results in decreased activity of KCNH2 protein; Fluvoxamine binds to and results in decreased activity of KCNH2 protein; Fluvoxamine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Fluvoxamine results in decreased activity of KCNH2 protein		 CTD PMID:20071423 PMID:21158687 PMID:24052561 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions		 EXP
ISO		 Fluvoxamine results in increased expression of NOS2 mRNA
Fluvoxamine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]
Fluvoxamine inhibits the reaction [Carrageenan results in increased expression of NOS2 mRNA]		 CTD PMID:12429386 PMID:27803785 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Prkcb protein kinase C, beta multiple interactions EXP [Haloperidol co-treated with Fluvoxamine] affects the expression of PRKCB protein CTD PMID:15967061 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP
ISO		 Fluvoxamine inhibits the reaction [Carrageenan results in increased expression of PTGS2 mRNA]
Fluvoxamine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 mRNA]		 CTD PMID:27803785 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 decreases activity
affects response to substance		 ISO Fluvoxamine results in decreased activity of SCN5A protein
SCN5A protein affects the susceptibility to Fluvoxamine		 CTD PMID:19875396 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP
ISO		 Fluvoxamine inhibits the reaction [Carrageenan results in increased expression of VCAM1 mRNA]
Fluvoxamine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of VCAM1 mRNA]		 CTD PMID:27803785 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    role 19825
      biological role 19825
        biochemical role 19360
          volatile oil component 6002
            valerophenone 20
              5-methoxyvalerophenone 20
                5-methoxyvalerophenone O-(2-aminoethyl)oxime + 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      carbon group element atom 19668
                        carbon atom 19657
                          organic molecular entity 19657
                            organic group 18569
                              organic divalent group 18560
                                organodiyl group 18560
                                  carbonyl group 18468
                                    carbonyl compound 18468
                                      ketone 16216
                                        aromatic ketone 11936
                                          valerophenone 20
                                            5-methoxyvalerophenone 20
                                              5-methoxyvalerophenone O-(2-aminoethyl)oxime + 20
paths to the root