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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:hydrochloride
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Accession:CHEBI:36807 term browser browse the term
Definition:A salt formally resulting from the reaction of hydrochloric acid with an organic base.
Synonyms:related_synonym: Hydrochlorid;   hydrochloride salts;   hydrochlorides

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(1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd1 dopamine receptor D1 multiple interactions
affects localization		 ISO A 77636 binds to and results in increased activity of DRD1 protein; SCH 23390 inhibits the reaction [A 77636 affects the localization of DRD1 protein]; SCH 23390 inhibits the reaction [A 77636 results in increased activity of DRD1 protein] CTD PMID:15985612 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541 		JBrowse link
(S)-duloxetine hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Duloxetine Hydrochloride binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases activity
multiple interactions		 ISO Duloxetine Hydrochloride results in decreased activity of CYP17A1 protein
Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone]; Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Progesterone] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone]; Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone]; Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone] which results in increased chemical synthesis of Androstenedione]; Duloxetine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased hydroxylation of Pregnenolone]; Duloxetine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased hydroxylation of Progesterone]; Duloxetine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone]; Duloxetine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone]		 CTD PMID:29100959 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP [furafylline results in decreased activity of CYP1A2 protein] which results in decreased glutathionylation of Duloxetine Hydrochloride; CYP1A2 protein results in increased activity of and results in increased glutathionylation of Duloxetine Hydrochloride CTD PMID:20669986 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions EXP [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased glutathionylation of Duloxetine Hydrochloride; CYP2D6 protein results in increased activity of and results in increased glutathionylation of Duloxetine Hydrochloride CTD PMID:20669986 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Duloxetine Hydrochloride results in increased expression of HMOX1 mRNA CTD PMID:29134401 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Duloxetine Hydrochloride results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253 		JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 multiple interactions ISO Duloxetine Hydrochloride results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA]; Duloxetine Hydrochloride results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] CTD PMID:22164246 NCBI chr 3:41,019,898...41,181,070
Ensembl chr 3:41,019,898...41,181,070 		JBrowse link
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 multiple interactions ISO Duloxetine Hydrochloride results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA] CTD PMID:22164246 NCBI chr 8:33,435,493...33,463,410
Ensembl chr 8:33,433,905...33,463,467 		JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 multiple interactions ISO Duloxetine Hydrochloride results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] CTD PMID:22164246 NCBI chr11:35,011,007...35,262,362
Ensembl chr11:35,024,196...35,099,383 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization ISO Duloxetine Hydrochloride affects the localization of NFE2L2 protein CTD PMID:29134401 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Prl prolactin increases expression ISO Duloxetine Hydrochloride results in increased expression of PRL protein CTD PMID:17606668 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299 		JBrowse link
4-fluoro-N-\{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl\}benzamide hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions EXP [1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to 1-(3-chlorophenyl)piperazine; [1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine; [1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Physostigmine; tertatolol inhibits the reaction [[1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine]; tertatolol inhibits the reaction [[1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Physostigmine] CTD PMID:8539317 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896 		JBrowse link
acridine orange term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases response to substance ISO BAX protein results in increased susceptibility to Acridine Orange CTD PMID:16177561 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO [Acridine Orange binds to Platinum Compounds] which results in increased expression of GSTP1 mRNA; [Acridine Orange binds to Platinum] which results in increased expression of GSTP1 mRNA CTD PMID:16814760 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Acridine Orange results in increased stability of and results in increased activity of TP53 protein CTD PMID:16177561 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
atomoxetine hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases hydroxylation ISO CYP2D6 protein results in increased hydroxylation of Atomoxetine Hydrochloride CTD PMID:17470523 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436 		JBrowse link
auramine O term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions
increases expression		 ISO ALDH1A1 protein promotes the reaction [Benzophenoneidum results in increased lipidation of and results in increased cleavage of MAP1LC3B protein]
Benzophenoneidum results in increased expression of ALDH1A1 protein		 CTD PMID:28722353 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330 		JBrowse link
G Ano6 anoctamin 6 increases expression ISO Benzophenoneidum results in increased expression of ANO6 protein CTD PMID:28722353 NCBI chr 7:137,142,063...137,335,208
Ensembl chr 7:137,142,170...137,335,208 		JBrowse link
G Araf A-Raf proto-oncogene, serine/threonine kinase increases expression ISO Benzophenoneidum results in increased expression of ARAF protein CTD PMID:28722353 NCBI chr  X:1,369,534...1,391,603
Ensembl chr  X:1,379,194...1,390,873 		JBrowse link
G Atp6ap2 ATPase H+ transporting accessory protein 2 increases expression ISO Benzophenoneidum results in increased expression of ATP6AP2 protein CTD PMID:28722353 NCBI chr  X:11,137,889...11,164,854
Ensembl chr  X:11,136,939...11,164,915 		JBrowse link
G Ccdc22 coiled-coil domain containing 22 increases expression ISO Benzophenoneidum results in increased expression of CCDC22 protein CTD PMID:28722353 NCBI chr  X:15,742,978...15,754,925
Ensembl chr  X:15,742,978...15,754,925 		JBrowse link
G Ccdc39 coiled-coil domain containing 39 increases expression ISO Benzophenoneidum results in increased expression of CCDC39 protein CTD PMID:28722353 NCBI chr 2:120,278,605...120,367,829
Ensembl chr 2:120,278,605...120,316,600 		JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression ISO Benzophenoneidum results in increased expression of CD44 protein CTD PMID:28722353 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658 		JBrowse link
G Chtf18 chromosome transmission fidelity factor 18 increases expression ISO Benzophenoneidum results in increased expression of CHTF18 protein CTD PMID:28722353 NCBI chr10:15,090,762...15,098,825
Ensembl chr10:15,090,316...15,098,791 		JBrowse link
G Commd1 copper metabolism domain containing 1 increases expression ISO Benzophenoneidum results in increased expression of COMMD1 protein CTD PMID:28722353 NCBI chr14:107,664,321...107,759,974
Ensembl chr14:107,664,255...107,760,191 		JBrowse link
G Cops7b COP9 signalosome subunit 7B increases expression ISO Benzophenoneidum results in increased expression of COPS7B protein CTD PMID:28722353 NCBI chr 9:93,607,199...93,633,064
Ensembl chr 9:93,607,477...93,633,064 		JBrowse link
G Cul3 cullin 3 increases expression ISO Benzophenoneidum results in increased expression of CUL3 protein CTD PMID:28722353 NCBI chr 9:86,044,485...86,129,066
Ensembl chr 9:86,044,485...86,129,329 		JBrowse link
G Dynlt1 dynein light chain Tctex-type 1 increases expression ISO Benzophenoneidum results in increased expression of DYNLT1 protein CTD PMID:28722353 NCBI chr 1:47,206,892...47,213,785
Ensembl chr 1:47,206,895...47,213,749 		JBrowse link
G Eif4g3 eukaryotic translation initiation factor 4 gamma, 3 increases expression ISO Benzophenoneidum results in increased expression of EIF4G3 protein CTD PMID:28722353 NCBI chr 5:156,343,663...156,564,037
Ensembl chr 5:156,396,695...156,564,037 		JBrowse link
G Fastkd2 FAST kinase domains 2 increases expression ISO Benzophenoneidum results in increased expression of FASTKD2 protein CTD PMID:28722353 NCBI chr 9:70,448,386...70,471,420
Ensembl chr 9:70,450,444...70,470,550 		JBrowse link
G Hook3 hook microtubule-tethering protein 3 increases expression ISO Benzophenoneidum results in increased expression of HOOK3 protein CTD PMID:28722353 NCBI chr16:70,710,347...70,818,789 JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 increases expression ISO Benzophenoneidum results in increased expression of HSD17B7 protein CTD PMID:28722353 NCBI chr13:88,288,116...88,308,019
Ensembl chr13:88,288,046...88,307,988 		JBrowse link
G Htt huntingtin increases expression ISO Benzophenoneidum results in increased expression of HTT protein CTD PMID:28722353 NCBI chr14:81,105,139...81,254,637
Ensembl chr14:81,105,139...81,254,637 		JBrowse link
G Iqgap3 IQ motif containing GTPase activating protein 3 increases expression ISO Benzophenoneidum results in increased expression of IQGAP3 protein CTD PMID:28722353 NCBI chr 2:187,447,477...187,489,630
Ensembl chr 2:187,447,501...187,489,630 		JBrowse link
G Kifap3 kinesin-associated protein 3 increases expression ISO Benzophenoneidum results in increased expression of KIFAP3 protein CTD PMID:28722353 NCBI chr13:82,072,497...82,217,256
Ensembl chr13:82,072,497...82,217,252 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO ALDH1A1 protein promotes the reaction [Benzophenoneidum results in increased lipidation of and results in increased cleavage of MAP1LC3B protein]; Benzophenoneidum results in increased lipidation of and results in increased cleavage of MAP1LC3B protein CTD PMID:28722353 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 increases expression ISO Benzophenoneidum results in increased expression of MAP2K4 protein CTD PMID:28722353 NCBI chr10:52,196,121...52,301,887
Ensembl chr10:52,196,124...52,290,657 		JBrowse link
G Mbd3 methyl-CpG binding domain protein 3 increases expression ISO Benzophenoneidum results in increased expression of MBD3 protein CTD PMID:28722353 NCBI chr 7:12,179,046...12,186,251
Ensembl chr 7:12,179,203...12,186,656 		JBrowse link
G Noa1 nitric oxide associated 1 increases expression ISO Benzophenoneidum results in increased expression of NOA1 protein CTD PMID:28722353 NCBI chr14:33,107,868...33,124,172
Ensembl chr14:33,108,024...33,124,171 		JBrowse link
G Nup62 nucleoporin 62 increases expression ISO Benzophenoneidum results in increased expression of NUP62 protein CTD PMID:28722353 NCBI chr 1:100,811,140...100,827,119
Ensembl chr 1:100,811,755...100,827,111 		JBrowse link
G Plcg1 phospholipase C, gamma 1 increases expression ISO Benzophenoneidum results in increased expression of PLCG1 protein CTD PMID:28722353 NCBI chr 3:156,727,642...156,758,307
Ensembl chr 3:156,727,642...156,758,307 		JBrowse link
G Ppp4r1 protein phosphatase 4, regulatory subunit 1 increases expression ISO Benzophenoneidum results in increased expression of PPP4R1 protein CTD PMID:28722353 NCBI chr 9:113,515,312...113,573,308
Ensembl chr 9:113,534,326...113,573,307 		JBrowse link
G Prim2 DNA primase subunit 2 increases expression ISO Benzophenoneidum results in increased expression of PRIM2 protein CTD PMID:28722353 NCBI chr 9:38,535,435...38,745,058
Ensembl chr 9:38,536,920...38,745,099 		JBrowse link
G Prom1 prominin 1 increases expression ISO Benzophenoneidum results in increased expression of PROM1 protein CTD PMID:28722353 NCBI chr14:71,532,321...71,637,400
Ensembl chr14:71,533,063...71,637,417 		JBrowse link
G Prorp protein only RNase P catalytic subunit increases expression ISO Benzophenoneidum results in increased expression of PRORP protein CTD PMID:28722353 NCBI chr 6:76,079,880...76,171,298
Ensembl chr 6:76,079,880...76,171,296 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 increases expression ISO Benzophenoneidum results in increased expression of SHMT1 protein CTD PMID:28722353 NCBI chr10:47,030,813...47,059,216
Ensembl chr10:47,031,050...47,059,216 		JBrowse link
G Srsf11 serine and arginine rich splicing factor 11 increases expression ISO Benzophenoneidum results in increased expression of SRSF11 protein CTD PMID:28722353 NCBI chr 2:264,837,463...264,864,296
Ensembl chr 2:264,837,472...264,864,265 		JBrowse link
G Tbc1d15 TBC1 domain family, member 15 increases expression ISO Benzophenoneidum results in increased expression of TBC1D15 protein CTD PMID:28722353 NCBI chr 7:58,164,190...58,219,804
Ensembl chr 7:58,164,198...58,219,790 		JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO Benzophenoneidum results in increased expression of TFAM protein CTD PMID:28722353 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151 		JBrowse link
G Usp24 ubiquitin specific peptidase 24 increases expression ISO Benzophenoneidum results in increased expression of USP24 protein CTD PMID:28722353 NCBI chr 5:125,896,725...126,030,411
Ensembl chr 5:125,896,725...126,030,401 		JBrowse link
G Washc5 WASH complex subunit 5 increases expression ISO Benzophenoneidum results in increased expression of WASHC5 protein CTD PMID:28722353 NCBI chr 7:99,625,379...99,677,237
Ensembl chr 7:99,625,619...99,677,268 		JBrowse link
colesevelam hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crp C-reactive protein decreases expression ISO Colesevelam Hydrochloride results in decreased expression of CRP protein CTD PMID:16616026 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
increases expression		 ISO Colesevelam Hydrochloride promotes the reaction [Simvastatin results in increased expression of HMGCR mRNA]
Colesevelam Hydrochloride results in increased expression of HMGCR mRNA		 CTD PMID:22120639 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654 		JBrowse link
G Ldlr low density lipoprotein receptor increases expression ISO Colesevelam Hydrochloride results in increased expression of LDLR mRNA CTD PMID:22120639 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903 		JBrowse link
colforsin daropate hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression		 ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of ABCB1 mRNA] CTD PMID:12926078 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 multiple interactions
decreases expression		 ISO Colforsin inhibits the reaction [Doxorubicin results in increased expression of ABCB4 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in decreased expression of ABCB4 mRNA] CTD PMID:12926078 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO Colforsin results in increased expression of ABCC2 mRNA; Colforsin results in increased expression of ABCC2 protein CTD PMID:19580841 PMID:26049102 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression
multiple interactions		 ISO Colforsin results in increased expression of ABCG2 mRNA
Colforsin inhibits the reaction [anandamide inhibits the reaction [CREB1 protein modified form binds to ABCG2 promoter]]		 CTD PMID:19580841 PMID:30610963 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases phosphorylation ISO Colforsin results in increased phosphorylation of ACACA protein CTD PMID:18390901 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910 		JBrowse link
G Ache acetylcholinesterase increases activity
increases expression		 EXP Colforsin results in increased activity of ACHE protein; Colforsin results in increased activity of ACHE protein alternative form
Colforsin results in increased expression of ACHE mRNA		 CTD PMID:18514641 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G Acsl3 acyl-CoA synthetase long-chain family member 3 increases expression ISO Colforsin results in increased expression of ACSL3 mRNA CTD PMID:16751804 NCBI chr 9:84,569,601...84,593,565
Ensembl chr 9:84,569,597...84,593,565 		JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions		 ISO
EXP		 Colforsin results in decreased expression of ACTA2 protein
Colforsin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]		 CTD PMID:21603974 PMID:27590029 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394 		JBrowse link
G Adam12 ADAM metallopeptidase domain 12 decreases expression ISO Colforsin results in decreased expression of ADAM12 mRNA CTD PMID:15313392 PMID:15967414 NCBI chr 1:205,951,840...206,286,294
Ensembl chr 1:205,956,342...206,282,575 		JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 decreases expression ISO Colforsin results in decreased expression of ADAMTS1 mRNA CTD PMID:15313392 PMID:15967414 NCBI chr11:25,342,119...25,350,938
Ensembl chr11:25,342,126...25,350,974 		JBrowse link
G Adcy5 adenylate cyclase 5 multiple interactions ISO ADCY5 protein results in increased susceptibility to [Colforsin co-treated with Quinpirole] CTD PMID:12223546 NCBI chr11:68,695,839...68,842,452
Ensembl chr11:68,695,839...68,842,320 		JBrowse link
G Adcy6 adenylate cyclase 6 affects response to substance ISO ADCY6 protein affects the susceptibility to Colforsin CTD PMID:12393090 NCBI chr 7:140,270,678...140,291,722
Ensembl chr 7:140,270,692...140,291,620 		JBrowse link
G Adcy9 adenylate cyclase 9 multiple interactions
increases activity		 ISO [Colforsin co-treated with Miconazole] results in increased activity of ADCY9 protein
Colforsin results in increased activity of ADCY9 protein		 CTD PMID:30607468 NCBI chr10:11,392,698...11,515,406
Ensembl chr10:11,392,625...11,512,600 		JBrowse link
G Adra1a adrenoceptor alpha 1A multiple interactions ISO [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] affects the reaction [[Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the transport of Potassium] CTD PMID:19419905 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451 		JBrowse link
G Adra2c adrenoceptor alpha 2C multiple interactions
affects localization
increases expression		 ISO AKAP13 protein modified form affects the reaction [Colforsin affects the localization of ADRA2C protein]; AKAP13 protein modified form affects the reaction [Colforsin results in increased expression of ADRA2C mRNA] CTD PMID:24701590 NCBI chr14:80,730,307...80,732,010
Ensembl chr14:80,730,307...80,732,010 		JBrowse link
G Adrb1 adrenoceptor beta 1 affects response to substance
multiple interactions		 ISO ADRB1 protein polymorphism affects the susceptibility to Colforsin
[[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of [ADRB1 protein binds to ADRB2 protein]] affects the reaction [KCNH2 protein results in increased transport of Potassium]; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] promotes the reaction [[ADRB1 protein binds to ADRB2 protein] which results in increased abundance of Cyclic AMP]; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of [ADRB1 protein binds to ADRB2 protein]		 CTD PMID:14502278 PMID:19419905 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985 		JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions
increases expression
increases phosphorylation		 ISO [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of [ADRB1 protein binds to ADRB2 protein]] affects the reaction [KCNH2 protein results in increased transport of Potassium]; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] promotes the reaction [[ADRB1 protein binds to ADRB2 protein] which results in increased abundance of Cyclic AMP]; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of [ADRB1 protein binds to ADRB2 protein]
Colforsin results in increased expression of ADRB2 mRNA
Colforsin results in increased phosphorylation of ADRB2 protein		 CTD PMID:14722251 PMID:19419905 PMID:24705868 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834 		JBrowse link
G Adrb3 adrenoceptor beta 3 decreases expression ISO Colforsin results in decreased expression of ADRB3 mRNA CTD PMID:10725275 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
affects localization		 ISO [Colforsin results in increased activity of AHR protein] which results in increased expression of CXCL8 mRNA; [Colforsin results in increased activity of AHR protein] which results in increased expression of CXCL8 protein; [Colforsin results in increased activity of AHR protein] which results in increased secretion of CXCL8 protein; Colforsin promotes the reaction [[AHR protein binds to RELB protein] which binds to CXCL8 promoter]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin promotes the reaction [[AHR protein binds to RELB protein] which binds to CXCL8 promoter]]; PDE2A protein inhibits the reaction [Colforsin affects the localization of AHR protein]
AHR protein inhibits the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PER1 mRNA]		 CTD PMID:15972329 PMID:17329248 PMID:17823304 PMID:23291558 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Akap13 A-kinase anchoring protein 13 multiple interactions ISO AKAP13 protein modified form affects the reaction [Colforsin affects the localization of ADRA2C protein]; AKAP13 protein modified form affects the reaction [Colforsin results in increased expression of ADRA2C mRNA]; AKAP13 protein modified form inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein] CTD PMID:24701590 NCBI chr 1:137,089,558...137,315,272
Ensembl chr 1:137,014,272...137,315,272 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases expression ISO Colforsin results in decreased expression of AKR1C3 mRNA CTD PMID:28235592 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Colforsin inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT1 protein] CTD PMID:16339297 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions EXP Colforsin inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT2 protein] CTD PMID:16339297 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 multiple interactions EXP Colforsin inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT3 protein] CTD PMID:16339297 NCBI chr13:95,076,308...95,348,913
Ensembl chr13:95,081,390...95,348,913 		JBrowse link
G Alb albumin multiple interactions EXP Colforsin inhibits the reaction [Carbon Tetrachloride results in decreased expression of ALB protein] CTD PMID:27590029 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Alpi alkaline phosphatase, intestinal multiple interactions ISO Colforsin inhibits the reaction [Methotrexate results in increased activity of ALPI protein] CTD PMID:16598758 NCBI chr 9:94,197,616...94,201,910
Ensembl chr 9:94,197,618...94,201,084 		JBrowse link
G Alpp alkaline phosphatase, placental increases expression
multiple interactions		 ISO Colforsin results in increased expression of ALPP mRNA
[Colforsin results in increased abundance of Cyclic AMP] which results in increased expression of ALPP mRNA; Chlorpromazine inhibits the reaction [Colforsin results in increased expression of ALPP mRNA]; Clozapine inhibits the reaction [Colforsin results in increased expression of ALPP mRNA]; Desipramine inhibits the reaction [Colforsin results in increased expression of ALPP mRNA]		 CTD PMID:16036225 NCBI chr 9:94,189,961...94,193,054
Ensembl chr 9:94,190,067...94,192,813 		JBrowse link
G Aoc1 amine oxidase, copper containing 1 increases activity EXP Colforsin results in increased activity of AOC1 protein CTD PMID:2860926 NCBI chr 4:78,496,043...78,515,582
Ensembl chr 4:78,496,043...78,515,584 		JBrowse link
G Appbp2 amyloid beta precursor protein binding protein 2 decreases expression ISO Colforsin results in decreased expression of APPBP2 mRNA CTD PMID:16751804 NCBI chr10:72,503,347...72,545,141
Ensembl chr10:72,503,347...72,545,141 		JBrowse link
G Ar androgen receptor multiple interactions
increases expression		 ISO AR protein affects the reaction [Colforsin results in decreased expression of SESN1 protein]; AR protein promotes the reaction [Colforsin results in increased expression of HMGCR protein]; AR protein promotes the reaction [Colforsin results in increased expression of INSIG1 protein]; AR protein promotes the reaction [Colforsin results in increased expression of KLK2 protein]; AR protein promotes the reaction [Colforsin results in increased expression of KLK3 protein]; Colforsin promotes the reaction [Metribolone results in increased activity of AR protein]
Colforsin results in increased expression of AR protein		 CTD PMID:16751804 PMID:17219378 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Areg amphiregulin increases expression
multiple interactions		 ISO Colforsin results in increased expression of AREG mRNA
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of AREG mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of AREG protein]		 CTD PMID:15284208 PMID:15313392 PMID:15474502 PMID:15967414 PMID:20378682 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179 		JBrowse link
G Arntl aryl hydrocarbon receptor nuclear translocator-like increases expression ISO Colforsin results in increased expression of ARNTL mRNA CTD PMID:30524225 NCBI chr 1:178,039,002...178,137,469
Ensembl chr 1:178,039,063...178,137,465 		JBrowse link
G Arrb1 arrestin, beta 1 multiple interactions ISO Colforsin inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA] CTD PMID:24334028 NCBI chr 1:164,502,099...164,573,947
Ensembl chr 1:164,502,389...164,593,139 		JBrowse link
G Atxn3 ataxin 3 decreases expression ISO Colforsin results in decreased expression of ATXN3 mRNA CTD PMID:16751804 NCBI chr 6:125,817,420...125,853,461
Ensembl chr 6:125,819,640...125,853,461 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
increases expression		 ISO 1-bromopropane inhibits the reaction [Colforsin results in increased expression of BDNF mRNA]; 1-bromopropane inhibits the reaction [Colforsin results in increased expression of BDNF protein]
Colforsin results in increased expression of BDNF mRNA; Colforsin results in increased expression of BDNF protein		 CTD PMID:19189864 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210 		JBrowse link
G Bmp6 bone morphogenetic protein 6 multiple interactions ISO BMP6 protein inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA]; BMP6 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]; BMP6 protein inhibits the reaction [Colforsin results in increased expression of HSD3B1 mRNA]; BMP6 protein inhibits the reaction [Colforsin results in increased expression of OXT mRNA]; BMP6 protein inhibits the reaction [Colforsin results in increased expression of STAR mRNA]; BMP6 protein inhibits the reaction [Colforsin results in increased secretion of Progesterone]; FST protein inhibits the reaction [BMP6 protein inhibits the reaction [Colforsin results in increased secretion of Progesterone]] CTD PMID:18936084 NCBI chr17:26,955,142...27,112,820
Ensembl chr17:26,955,142...27,112,820 		JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G multiple interactions EXP Mibefradil inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CACNA1G protein]; Nickel inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CACNA1G protein] CTD PMID:17110049 NCBI chr10:82,129,071...82,197,828
Ensembl chr10:82,129,506...82,197,848 		JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H multiple interactions EXP Mibefradil inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CACNA1H protein]; Nickel inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CACNA1H protein] CTD PMID:17110049 NCBI chr10:14,730,932...14,789,201
Ensembl chr10:14,730,941...14,788,617 		JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I multiple interactions EXP Mibefradil inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CACNA1I protein]; Nickel inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CACNA1I protein] CTD PMID:17110049 NCBI chr 7:121,521,787...121,619,300
Ensembl chr 7:121,511,097...121,619,283 		JBrowse link
G Calcrl calcitonin receptor like receptor multiple interactions ISO Colforsin inhibits the reaction [EDN1 protein results in increased expression of CALCRL mRNA] CTD PMID:25194819 NCBI chr 3:71,747,938...71,845,487
Ensembl chr 3:71,747,956...71,845,232 		JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 increases expression ISO Colforsin results in increased expression of CAMKK2 mRNA CTD PMID:16751804 NCBI chr12:39,253,409...39,302,601
Ensembl chr12:39,253,409...39,302,601 		JBrowse link
G Cask calcium/calmodulin dependent serine protein kinase multiple interactions
increases phosphorylation		 EXP Colforsin promotes the reaction [CASK protein modified form binds to TBR1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of CASK protein] CTD PMID:20067577 NCBI chr  X:9,815,652...10,156,155
Ensembl chr  X:9,815,652...10,156,155 		JBrowse link
G Casp1 caspase 1 increases activity EXP Colforsin results in increased activity of CASP1 mRNA; Colforsin results in increased activity of CASP1 protein CTD PMID:21832250 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 ISO
EXP		 Colforsin results in increased activity of CASP3 protein
Colforsin inhibits the reaction [Puromycin Aminonucleoside results in increased activity of CASP3 protein]
KT 5720 inhibits the reaction [Colforsin results in increased activity of CASP3 protein]
Colforsin inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]		 CTD PMID:16396944 PMID:20131233 PMID:21745194 PMID:31278978 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cat catalase multiple interactions EXP Colforsin inhibits the reaction [mancozeb results in decreased activity of CAT protein] CTD PMID:29283200 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Colforsin inhibits the reaction [Reactive Oxygen Species results in increased expression of CCL5 mRNA]; Colforsin inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA] CTD PMID:10495789 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315 		JBrowse link
G Cd55 CD55 molecule (Cromer blood group) multiple interactions
increases expression		 ISO 3',4'-dimethoxy-alpha-naphthoflavone inhibits the reaction [Colforsin results in increased expression of CD55 mRNA] CTD PMID:22553215 NCBI chr13:47,125,156...47,153,557
Ensembl chr13:47,126,741...47,154,292 		JBrowse link
G Cdc6 cell division cycle 6 increases expression ISO Colforsin results in increased expression of CDC6 mRNA CTD PMID:16751804 NCBI chr10:86,819,477...86,833,301
Ensembl chr10:86,819,472...86,833,402 		JBrowse link
G Cdh1 cadherin 1 affects activity ISO Colforsin affects the activity of CDH1 protein CTD PMID:10413674 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions
increases expression		 ISO
EXP		 Colforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CEBPA mRNA]
Colforsin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of CEBPA protein]
Colforsin results in increased expression of CEBPA protein		 CTD PMID:17407152 PMID:21832167 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression
multiple interactions		 ISO
EXP		 Colforsin results in increased expression of CEBPB mRNA
[Atrazine co-treated with Colforsin] results in increased expression of CEBPB protein		 CTD PMID:14684744 PMID:25253736 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910 		JBrowse link
G Cftr CF transmembrane conductance regulator affects localization
increases activity
multiple interactions		 ISO
EXP		 Colforsin affects the localization of CFTR protein
Colforsin results in increased activity of CFTR protein
[Colforsin co-treated with Genistein] results in increased activity of CFTR protein; AICA ribonucleotide inhibits the reaction [Colforsin results in increased activity of CFTR protein]
[1-Methyl-3-isobutylxanthine co-treated with Colforsin] results in increased activity of CFTR protein
3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone inhibits the reaction [[[Colforsin co-treated with Genistein] results in increased activity of CFTR protein] which results in increased transport of Iodides]; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [Colforsin results in increased activity of CFTR protein]; 5-butyl-6-hydroxy-10-chlorobenzo(c)quinolizinium chloride inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]; 5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]; 6-hydroxy-10-chlorobenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]; [1-Methyl-3-isobutylxanthine co-treated with Colforsin] results in increased activity of CFTR protein; [1-Methyl-3-isobutylxanthine co-treated with Colforsin] results in increased activity of CFTR protein mutant form; [5-butyl-6-hydroxy-10-chlorobenzo(c)quinolizinium chloride co-treated with Colforsin] results in increased activity of CFTR protein mutant form; [[Colforsin co-treated with Genistein] results in increased activity of CFTR protein] which results in increased transport of Iodides; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CFTR protein; [Colforsin co-treated with Genistein] results in increased activity of CFTR protein; [Colforsin co-treated with lumacaftor] results in increased activity of CFTR protein mutant form; [Colforsin co-treated with NS 004] results in increased activity of CFTR protein mutant form; [ivacaftor co-treated with Colforsin co-treated with lumacaftor] results in increased activity of CFTR protein mutant form; [ivacaftor co-treated with Colforsin] results in increased activity of CFTR protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Brefeldin A inhibits the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Brefeldin A inhibits the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]; Colforsin binds to and results in decreased activity of CFTR protein; Colforsin promotes the reaction [CFTR protein affects the export of Chlorides]; Colforsin results in increased phosphorylation of and results in increased activity of CFTR protein; fenamic acid inhibits the reaction [[[Colforsin co-treated with Genistein] results in increased activity of CFTR protein] which results in increased transport of Iodides]; fenamic acid inhibits the reaction [Colforsin results in increased activity of CFTR protein]; geldanamycin promotes the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; geldanamycin promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Glyburide inhibits the reaction [[[Colforsin co-treated with Genistein] results in increased activity of CFTR protein] which results in increased transport of Iodides]; Glyburide inhibits the reaction [Colforsin results in increased activity of CFTR protein]; miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased activity of CFTR protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of CFTR protein]; Ozone inhibits the reaction [Colforsin results in increased activity of CFTR protein]; Thapsigargin promotes the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Thapsigargin promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; VRT 532 analog promotes the reaction [Colforsin results in increased activity of CFTR protein mutant form]; VRT 532 promotes the reaction [Colforsin results in increased activity of CFTR protein mutant form]
Colforsin analog results in increased activity of CFTR protein mutant form; Colforsin results in increased activity of CFTR protein; Colforsin results in increased activity of CFTR protein mutant form		 CTD PMID:12519745 PMID:12914781 PMID:14502435 PMID:14967738 PMID:15163550 PMID:15194485 PMID:15246976 PMID:15389550 PMID:15517342 PMID:15763242 PMID:15790911 PMID:15986093 PMID:15994425 PMID:16027156 PMID:16038730 PMID:17596272 PMID:18230692 PMID:19061877 PMID:21724857 PMID:22074181 PMID:32374624 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676 		JBrowse link
G Cga glycoprotein hormones, alpha polypeptide increases secretion
increases expression
multiple interactions		 ISO
EXP		 Colforsin results in increased secretion of CGA protein
Colforsin results in increased expression of CGA mRNA
Colforsin promotes the reaction [CGA protein results in increased abundance of Cyclic AMP]
Colforsin inhibits the reaction [ESR2 gene mutant form inhibits the reaction [CGA protein results in increased abundance of Cyclic AMP]]		 CTD PMID:8404651 PMID:16503475 PMID:20378682 NCBI chr 5:50,362,491...50,393,368
Ensembl chr 5:50,381,244...50,393,367 		JBrowse link
G Cidec cell death-inducing DFFA-like effector c increases expression ISO Colforsin results in increased expression of CIDEC protein CTD PMID:21097823 NCBI chr 4:145,377,482...145,390,497
Ensembl chr 4:145,377,431...145,390,497 		JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions
affects response to substance
increases activity		 ISO (1-(2-morpholin-4-yl-ethyl)-1H-indol-3-yl)-(2,2,3,3-tetramethylcyclopropyl)methanone inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; (1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; (4-ethyl-1-naphthalenyl)(1-(5-fluoropentyl)-1H-indol-3-yl)methanone inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-(2-cyclohexylethyl)-3-(2-methoxyphenylacetyl)indole inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-(5-fluoropentyl)-3-(4-methyl-1-naphthoyl)indole analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-(5-fluoropentyl)-3-(4-methyl-1-naphthoyl)indole inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-(cyclohexylmethyl)-1H-indole-3-carboxylic acid 8-quinolinyl ester inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-pentyfluoro-1H-indole-3-carboxylic acid 8-quinolinyl ester inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-pentyl-1H-indole-3-carboxylic acid 8-quinolinyl ester inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-pentyl-3-(1-naphthoyl)indole analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 2-(4-methoxyphenyl)-1-(1-pentyl-indol-3-yl)methanone inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 3-((adamantan-1-yl)carbonyl)-1-pentylindole analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 3-((adamantan-1-yl)carbonyl)-1-pentylindole inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol inhibits the reaction [Colforsin results in increased activity of CNR1 protein]; [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]; [Dronabinol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]; [Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased expression of CNR1 mRNA; AM 6527 analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; AM 6527 inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; CNR1 protein inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]; delta(9)-tetrahydrocannabinolic acid inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol inhibits the reaction [Colforsin results in increased activity of CNR1 protein]]; delta(9)-tetrahydrocannabinolic acid inhibits the reaction [Colforsin results in increased activity of CNR1 protein]; Dronabinol inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; Dronabinol inhibits the reaction [Colforsin results in increased activity of CNR1 protein]; FDU-PB-22 inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; FUB-PB-22 compound inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; Indazoles analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; Indoles analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-(1-adamantyl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-(1-adamantyl)-1-pentylindazole-3-carboxamide analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-(adamtan-1-yl)-1-pentyl-1H-indole-3-carboxamide analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-(adamtan-1-yl)-1-pentyl-1H-indole-3-carboxamide inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-1-naphthalenyl-1-pentyl-1H-indazole-3-carboxamide analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-1-naphthalenyl-1-pentyl-1H-indazole-3-carboxamide inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; napht-1-yl 1-(5-fluoropentyl)-1H-indole-3-carboxylate inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; THJ-2201 inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; XLR-11 analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; XLR-11 inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]
CNR1 protein affects the susceptibility to Colforsin		 CTD PMID:27429655 PMID:27527584 PMID:28861508 PMID:31154070 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056 		JBrowse link
G Cnr2 cannabinoid receptor 2 multiple interactions
increases activity
affects response to substance		 ISO (1-(2-morpholin-4-yl-ethyl)-1H-indol-3-yl)-(2,2,3,3-tetramethylcyclopropyl)methanone inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; (1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; (4-ethyl-1-naphthalenyl)(1-(5-fluoropentyl)-1H-indol-3-yl)methanone inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-(2-cyclohexylethyl)-3-(2-methoxyphenylacetyl)indole inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-(5-fluoropentyl)-3-(4-methyl-1-naphthoyl)indole analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-(5-fluoropentyl)-3-(4-methyl-1-naphthoyl)indole inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-(cyclohexylmethyl)-1H-indole-3-carboxylic acid 8-quinolinyl ester inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-pentyfluoro-1H-indole-3-carboxylic acid 8-quinolinyl ester inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-pentyl-1H-indole-3-carboxylic acid 8-quinolinyl ester inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-pentyl-3-(1-naphthoyl)indole analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 2-(4-methoxyphenyl)-1-(1-pentyl-indol-3-yl)methanone inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 3-((adamantan-1-yl)carbonyl)-1-pentylindole analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 3-((adamantan-1-yl)carbonyl)-1-pentylindole inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol inhibits the reaction [Colforsin results in increased activity of CNR2 protein]; [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]; [Dronabinol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]; [Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased expression of CNR2 mRNA; [virodhamine binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; AM 6527 analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; AM 6527 inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; CNR2 protein inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]; Dronabinol inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; Dronabinol inhibits the reaction [Colforsin results in increased activity of CNR2 protein]; FDU-PB-22 inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; FUB-PB-22 compound inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; Indazoles analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; Indoles analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-(1-adamantyl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-(1-adamantyl)-1-pentylindazole-3-carboxamide analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-(adamtan-1-yl)-1-pentyl-1H-indole-3-carboxamide analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-(adamtan-1-yl)-1-pentyl-1H-indole-3-carboxamide inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-1-naphthalenyl-1-pentyl-1H-indazole-3-carboxamide analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-1-naphthalenyl-1-pentyl-1H-indazole-3-carboxamide inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; napht-1-yl 1-(5-fluoropentyl)-1H-indole-3-carboxylate inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; Pertussis Toxin inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]; Pertussis Toxin inhibits the reaction [[virodhamine binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]; SR 144528 inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]; SR 144528 inhibits the reaction [[virodhamine binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]; THJ-2201 inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; XLR-11 analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; XLR-11 inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]
CNR2 protein affects the susceptibility to Colforsin		 CTD PMID:17558435 PMID:27429655 PMID:27527584 PMID:28861508 PMID:30504240 PMID:31154070 NCBI chr 5:154,242,010...154,268,126
Ensembl chr 5:154,260,062...154,268,126 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases activity
increases expression
increases phosphorylation
multiple interactions		 ISO
EXP		 Colforsin results in increased activity of CREB1 protein
Colforsin results in increased expression of CREB1 protein modified form
Colforsin results in increased phosphorylation of CREB1 protein
3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [resveratrol inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]]; Colforsin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CREB1 protein modified form]; Colforsin promotes the reaction [CREB1 protein binds to POU1F1 promoter]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]; Okadaic Acid inhibits the reaction [resveratrol inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]]; resveratrol inhibits the reaction [Colforsin promotes the reaction [CREB1 protein binds to POU1F1 promoter]]; resveratrol inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]; SIRT1 mutant form inhibits the reaction [resveratrol inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]]; SIRT1 protein inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]; SIRT1 protein mutant form inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]
AKAP13 protein modified form inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]; anandamide inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]; Colforsin inhibits the reaction [anandamide inhibits the reaction [CREB1 protein modified form binds to ABCG2 promoter]]; Colforsin results in increased phosphorylation of and results in increased activity of CREB1 protein
oxophenylarsine inhibits the reaction [Colforsin results in increased activity of CREB1 protein]; oxophenylarsine inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]; RTKI cpd inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]		 CTD PMID:10908723 PMID:15522277 PMID:17141199 PMID:17322281 PMID:17460731 PMID:17680988 PMID:18004999 PMID:20512473 PMID:21745194 PMID:23292070 PMID:24701590 PMID:27509375 PMID:27590029 PMID:28601556 PMID:29179997 PMID:30610963 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435 		JBrowse link
G Crebbp CREB binding protein multiple interactions ISO Colforsin promotes the reaction [GCM1 protein binds to CREBBP protein]; CREBBP protein affects the reaction [Colforsin results in increased activity of GCM1 protein] CTD PMID:16166624 NCBI chr10:11,590,994...11,721,039
Ensembl chr10:11,595,044...11,721,039 		JBrowse link
G Crem cAMP responsive element modulator increases expression EXP Colforsin results in increased expression of CREM mRNA; Colforsin results in increased expression of CREM mRNA alternative form; Colforsin results in increased expression of CREM protein CTD PMID:8810303 PMID:12791704 NCBI chr17:57,021,704...57,090,888
Ensembl chr17:57,031,766...57,090,888 		JBrowse link
G Crh corticotropin releasing hormone multiple interactions EXP CRH protein inhibits the reaction [[Colforsin co-treated with CGB3 protein] results in increased chemical synthesis of Cyclic AMP]; CRH protein inhibits the reaction [[Colforsin co-treated with CGB3 protein] results in increased chemical synthesis of Testosterone]; CRH protein inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]; CRH protein inhibits the reaction [Colforsin results in increased chemical synthesis of Testosterone] CTD PMID:2153673 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863 		JBrowse link
G Crls1 cardiolipin synthase 1 increases expression ISO Colforsin results in increased expression of CRLS1 mRNA CTD PMID:16751804 NCBI chr 3:125,503,638...125,522,460
Ensembl chr 3:125,503,638...125,522,441 		JBrowse link
G Cryab crystallin, alpha B multiple interactions EXP Colforsin inhibits the reaction [arsenite results in increased expression of CRYAB protein] CTD PMID:8769853 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 affects expression
multiple interactions
increases expression		 ISO
EXP		 Colforsin affects the expression of CYP11A1 mRNA
[Colforsin co-treated with Zearalenone] results in increased expression of CYP11A1 mRNA
Colforsin results in increased expression of CYP11A1 mRNA
[Colforsin co-treated with triptolide] results in decreased expression of CYP11A1 mRNA; Aminoglutethimide inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA]; BMP6 protein inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA]; Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA]; Metyrapone inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA]; Valproic Acid affects the reaction [Colforsin affects the expression of CYP11A1 mRNA]
[Atrazine co-treated with Colforsin] results in increased expression of CYP11A1 mRNA; RARRES2 protein inhibits the reaction [Colforsin results in increased expression of CYP11A1 protein]		 CTD PMID:14691014 PMID:16935330 PMID:17080404 PMID:18936084 PMID:20726872 PMID:22446829 PMID:22948218 PMID:25253736 PMID:25765474 PMID:25871633 PMID:26783879 PMID:28235592 PMID:31557376 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 increases expression
multiple interactions
increases activity		 ISO Colforsin results in increased expression of CYP11B1 mRNA
[1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene co-treated with Colforsin] affects the expression of CYP11B1 mRNA; [Colforsin co-treated with triptolide] results in decreased expression of CYP11B1 mRNA; Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of CYP11B1 mRNA]
Colforsin results in increased activity of CYP11B1 protein		 CTD PMID:12525251 PMID:17080404 PMID:19164467 PMID:19900470 PMID:21256172 PMID:25765474 PMID:25871633 PMID:28235592 PMID:31557376 NCBI chr 7:116,248,759...116,255,205
Ensembl chr 7:116,156,219...116,255,167 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases expression
multiple interactions
increases activity		 ISO Colforsin results in increased expression of CYP11B2 mRNA
1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene inhibits the reaction [Colforsin results in increased activity of CYP11B1 protein]; 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene inhibits the reaction [Colforsin results in increased activity of CYP11B1 protein]; Etomidate inhibits the reaction [Colforsin results in increased activity of CYP11B1 protein]
[1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene co-treated with Colforsin] affects the expression of CYP11B2 mRNA; [Colforsin co-treated with triptolide] results in decreased expression of CYP11B2 mRNA; Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of CYP11B2 mRNA]; Ketoconazole promotes the reaction [Colforsin results in increased expression of CYP11B2 mRNA]		 CTD PMID:16935330 PMID:17080404 PMID:18651133 PMID:19164467 PMID:19900470 PMID:21256172 PMID:22446829 PMID:25765474 PMID:25871633 PMID:28235592 PMID:31557376 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression
multiple interactions		 ISO Colforsin results in increased expression of CYP17A1 mRNA
[Colforsin co-treated with triptolide] results in decreased expression of CYP17A1 mRNA; Apigenin inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]; Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]; Ketoconazole inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]; Metyrapone inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]; TGFB1 protein inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]; Valproic Acid inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]		 CTD PMID:15625562 PMID:15886251 PMID:16935330 PMID:17080404 PMID:20726872 PMID:22446829 PMID:22461451 PMID:23370353 PMID:25871633 PMID:28235592 PMID:31100596 PMID:31557376 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases activity
increases expression
multiple interactions		 ISO
EXP		 Colforsin results in increased activity of CYP19A1 protein
Colforsin results in increased expression of CYP19A1 mRNA
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]; [Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP19A1 mRNA; [Colforsin results in increased activity of CYP19A1 protein] which results in increased abundance of Estradiol; [Colforsin results in increased activity of CYP19A1 protein] which results in increased abundance of Testosterone; Alitretinoin inhibits the reaction [NR5A2 protein promotes the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP19A1 mRNA]]; Aminoglutethimide inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]; Atrazine inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]; BMP6 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]; Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]; mono-(2-ethylhexyl)phthalate inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]; NR4A1 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]; NR4A2 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]; NR4A3 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]; NR5A2 protein promotes the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP19A1 mRNA]; Valproic Acid inhibits the reaction [Colforsin results in increased activity of CYP19A1 protein]; Valproic Acid inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]; ZNF461 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]
RARRES2 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 protein]		 CTD PMID:14691014 PMID:16357189 PMID:16935330 PMID:16996190 PMID:17080404 PMID:18936084 PMID:19822197 PMID:20087668 PMID:20723554 PMID:20726872 PMID:22446829 PMID:22461451 PMID:22948218 PMID:24361490 PMID:25765474 PMID:25871633 PMID:28235592 PMID:28859905 PMID:29701941 PMID:31100596 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
affects expression		 EXP
ISO		 Colforsin inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A1 protein]
Valproic Acid affects the reaction [Colforsin affects the expression of CYP1A1 mRNA]
Colforsin affects the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]		 CTD PMID:1849469 PMID:15710352 PMID:20726872 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO
EXP		 Colforsin affects the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]
Colforsin inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A2 protein]		 CTD PMID:1849469 PMID:15710352 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression EXP Colforsin results in increased expression of CYP1B1 mRNA; Colforsin results in increased expression of CYP1B1 protein CTD PMID:7588239 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases expression ISO Colforsin results in increased expression of CYP2A5 mRNA CTD PMID:11162586 NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484 		JBrowse link
G Dbh dopamine beta-hydroxylase multiple interactions
increases expression		 EXP Colforsin inhibits the reaction [Atrazine results in decreased expression of DBH protein]; Colforsin inhibits the reaction [Simazine results in decreased expression of DBH protein]
Colforsin results in increased expression of DBH protein		 CTD PMID:14550852 NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898 		JBrowse link
G Dct dopachrome tautomerase increases expression ISO Colforsin results in increased expression of DCT mRNA; Colforsin results in increased expression of DCT protein CTD PMID:17460731 PMID:28601556 NCBI chr15:103,208,174...103,245,033
Ensembl chr15:103,208,258...103,244,494 		JBrowse link
G Dio2 iodothyronine deiodinase 2 increases activity
multiple interactions
increases expression		 ISO
EXP		 Colforsin results in increased activity of DIO2 protein
Buthionine Sulfoximine inhibits the reaction [Colforsin results in increased activity of DIO2 protein]; Hydrogen Peroxide inhibits the reaction [Colforsin results in increased activity of DIO2 protein]; Hydrogen Peroxide inhibits the reaction [Colforsin results in increased expression of DIO2 mRNA]; Sodium Selenite inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Colforsin results in increased activity of DIO2 protein]]; U 0126 inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Colforsin results in increased activity of DIO2 protein]]; U 0126 inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Colforsin results in increased expression of DIO2 mRNA]]		 CTD PMID:18420745 PMID:19036883 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723 		JBrowse link
G Dio3 iodothyronine deiodinase 3 multiple interactions EXP Colforsin promotes the reaction [Hydrogen Peroxide results in increased expression of DIO3 mRNA] CTD PMID:18420745 NCBI chr 6:134,627,278...134,629,139
Ensembl chr 6:134,627,278...134,629,138 		JBrowse link
G Dnm1l dynamin 1-like multiple interactions
decreases expression		 ISO PINK1 protein affects the reaction [Colforsin results in decreased expression of DNM1L protein] CTD PMID:24792327 NCBI chr11:88,830,968...88,882,271
Ensembl chr11:88,830,957...88,880,198 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO [Quinpirole binds to and results in increased activity of DRD2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; epigallocatechin gallate inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]] CTD PMID:17958328 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642 		JBrowse link
G Dynll2 dynein light chain LC8-type 2 increases expression ISO Colforsin results in increased expression of DYNLL2 mRNA CTD PMID:16751804 NCBI chr10:75,262,536...75,281,302
Ensembl chr10:75,262,537...75,270,561 		JBrowse link
G Edn1 endothelin 1 multiple interactions ISO Colforsin inhibits the reaction [EDN1 protein results in increased expression of CALCRL mRNA]; Colforsin inhibits the reaction [EDN1 protein results in increased expression of ICAM2 mRNA] CTD PMID:25194819 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO [EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of HSPD1 mRNA; [EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD1 mRNA; [EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD1 protein; [EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD2 mRNA; [EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD2 protein; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of HSPD1 mRNA]; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD1 mRNA]; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD1 protein]; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD2 protein] CTD PMID:32092105 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egr1 early growth response 1 decreases expression
multiple interactions		 ISO Colforsin results in decreased expression of EGR1 mRNA; Colforsin results in decreased expression of EGR1 protein
Colforsin inhibits the reaction [Ethanol results in increased expression of EGR1 mRNA]; Colforsin inhibits the reaction [Ethanol results in increased expression of EGR1 protein]; Ethanol inhibits the reaction [Colforsin results in decreased expression of EGR1 mRNA]; Ethanol inhibits the reaction [Colforsin results in decreased expression of EGR1 protein]		 CTD PMID:29802914 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429 		JBrowse link
G Eif2b5 eukaryotic translation initiation factor 2B subunit epsilon increases expression ISO Colforsin results in increased expression of EIF2B5 mRNA CTD PMID:16751804 NCBI chr11:84,080,273...84,090,259
Ensembl chr11:84,080,273...84,090,259 		JBrowse link
G Ephx1 epoxide hydrolase 1 affects expression
multiple interactions		 ISO Colforsin affects the expression of EPHX1 mRNA
Valproic Acid affects the reaction [Colforsin affects the expression of EPHX1 mRNA]		 CTD PMID:20726872 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579 		JBrowse link
G Eps8 epidermal growth factor receptor pathway substrate 8 decreases expression ISO Colforsin results in decreased expression of EPS8 mRNA CTD PMID:15313392 PMID:15967414 NCBI chr 4:171,475,155...171,645,620
Ensembl chr 4:171,475,567...171,591,882 		JBrowse link
G Ereg epiregulin increases expression ISO Colforsin results in increased expression of EREG mRNA CTD PMID:15313392 PMID:15474502 PMID:15967414 PMID:20378682 NCBI chr14:18,577,620...18,591,395
Ensembl chr14:18,576,355...18,591,394 		JBrowse link
G Ervfrd-1 endogenous retrovirus group FRD member 1, envelope multiple interactions
increases expression
increases secretion		 ISO Colforsin promotes the reaction [Benzo(a)pyrene results in increased expression of ERVFRD-1 mRNA]
Colforsin results in increased expression of ERVFRD-1 mRNA; Colforsin results in increased expression of ERVFRD-1 protein
Colforsin results in increased secretion of ERVFRD-1 protein		 CTD PMID:24361490 PMID:29679653 PMID:31278978 NCBI chr12:25,161,130...25,168,182
Ensembl chr12:25,161,130...25,168,182 		JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO Colforsin results in decreased expression of ESR1 mRNA CTD PMID:31278978 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
decreases expression		 ISO Colforsin inhibits the reaction [ESR2 gene mutant form inhibits the reaction [CGA protein results in increased abundance of Cyclic AMP]]
Colforsin results in decreased expression of ESR2 mRNA		 CTD PMID:20378682 PMID:31278978 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251 		JBrowse link
G Esrra estrogen related receptor, alpha increases expression ISO Colforsin results in increased expression of ESRRA mRNA; Colforsin results in increased expression of ESRRA protein CTD PMID:20351196 NCBI chr 1:222,168,729...222,178,842
Ensembl chr 1:222,168,730...222,178,725 		JBrowse link
G Evi5 ecotropic viral integration site 5 increases expression ISO Colforsin results in increased expression of EVI5 mRNA CTD PMID:16751804 NCBI chr14:2,892,738...3,038,237
Ensembl chr14:2,892,753...3,038,237 		JBrowse link
G F2 coagulation factor II multiple interactions ISO Colforsin inhibits the reaction [F2 protein results in increased uptake of Manganese] CTD PMID:2125206 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031 		JBrowse link
G F2r coagulation factor II (thrombin) receptor multiple interactions ISO [C186 65 binds to and results in increased activity of F2R protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP] CTD PMID:22207716 NCBI chr 2:26,118,760...26,135,340
Ensembl chr 2:26,118,760...26,135,340 		JBrowse link
G F2rl3 F2R like thrombin or trypsin receptor 3 multiple interactions ISO [GYPGKF-NH(2) binds to and results in increased activity of F2RL3 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP] CTD PMID:22207716 NCBI chr16:18,817,797...18,819,790
Ensembl chr16:18,814,622...18,819,833 		JBrowse link
G Fads1 fatty acid desaturase 1 increases expression ISO Colforsin results in increased expression of FADS1 mRNA CTD PMID:16751804 NCBI chr 1:226,234,034...226,249,118
Ensembl chr 1:226,234,074...226,249,138 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO [Colforsin co-treated with 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime] results in increased expression of FASN mRNA; [Colforsin co-treated with Leflunomide] results in increased expression of FASN mRNA; [Colforsin co-treated with teriflunomide] results in increased expression of FASN mRNA CTD PMID:30364229 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901 		JBrowse link
G Fgf10 fibroblast growth factor 10 multiple interactions ISO Colforsin inhibits the reaction [FGF10 protein results in increased phosphorylation of MAPK1 protein]; Colforsin inhibits the reaction [FGF10 protein results in increased phosphorylation of MAPK3 protein] CTD PMID:12533312 PMID:14975937 NCBI chr 2:51,673,480...51,747,533
Ensembl chr 2:51,672,722...51,750,369 		JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression ISO Colforsin results in increased expression of FGF2 mRNA; Colforsin results in increased expression of FGF2 protein CTD PMID:10320526 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681 		JBrowse link
G Fgf5 fibroblast growth factor 5 decreases expression EXP Colforsin results in decreased expression of FGF5 mRNA CTD PMID:11598998 NCBI chr14:12,974,921...12,996,046
Ensembl chr14:12,974,921...12,995,584 		JBrowse link
G Fgf8 fibroblast growth factor 8 increases activity ISO Colforsin results in increased activity of FGF8 protein CTD PMID:15193767 NCBI chr 1:265,492,949...265,498,965
Ensembl chr 1:265,493,124...265,498,831 		JBrowse link
G Fgf9 fibroblast growth factor 9 multiple interactions ISO FGF9 protein inhibits the reaction [Colforsin promotes the reaction [IGF1 protein results in increased abundance of Estradiol]]; FGF9 protein inhibits the reaction [IGF1 protein promotes the reaction [Colforsin results in increased abundance of Progesterone]] CTD PMID:22798350 NCBI chr15:38,341,657...38,386,945
Ensembl chr15:38,341,089...38,387,316 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 increases expression ISO Colforsin results in increased expression of FGFR1 mRNA CTD PMID:10320526 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 increases expression ISO Colforsin results in increased expression of FGFR2 mRNA CTD PMID:10320526 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928 		JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 multiple interactions ISO Colforsin promotes the reaction [Dexamethasone results in increased expression of FKBP5 mRNA] CTD PMID:19255438 NCBI chr20:7,976,704...8,097,290
Ensembl chr20:7,976,713...8,019,020 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression EXP Colforsin results in increased expression of FOSB mRNA; Colforsin results in increased expression of FOSB protein CTD PMID:17324382 NCBI chr 1:80,214,691...80,221,417
Ensembl chr 1:80,214,494...80,221,710 		JBrowse link
G Fshb follicle stimulating hormone subunit beta increases expression EXP Colforsin results in increased expression of FSHB mRNA; Colforsin results in increased expression of FSHB protein CTD PMID:8404651 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131 		JBrowse link
G Fst follistatin multiple interactions ISO FST protein inhibits the reaction [BMP6 protein inhibits the reaction [Colforsin results in increased secretion of Progesterone]]; FST protein inhibits the reaction [INHBA protein inhibits the reaction [Colforsin results in increased secretion of Progesterone]] CTD PMID:18936084 NCBI chr 2:46,537,589...46,544,813
Ensembl chr 2:46,538,700...46,544,457 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions EXP
ISO		 [Dexamethasone co-treated with Colforsin] results in increased expression of G6PC1 mRNA
Colforsin inhibits the reaction [Leflunomide results in increased expression of G6PC1 mRNA]; Colforsin inhibits the reaction [teriflunomide results in increased expression of G6PC1 mRNA]		 CTD PMID:18972406 PMID:30364229 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 increases expression EXP Colforsin results in increased expression of GABRA1 CTD PMID:9147380 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665 		JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 decreases expression EXP Colforsin results in decreased expression of GABRA6 CTD PMID:9147380 NCBI chr10:27,847,447...27,862,896
Ensembl chr10:27,847,439...27,862,868 		JBrowse link
G Gas6 growth arrest specific 6 decreases expression ISO Colforsin results in decreased expression of GAS6 mRNA CTD PMID:15313392 NCBI chr16:81,213,364...81,243,824
Ensembl chr16:81,213,364...81,243,757 		JBrowse link
G Gast gastrin multiple interactions
increases secretion		 ISO
EXP		 Calcium promotes the reaction [Colforsin results in increased secretion of GAST protein]; Nitrendipine inhibits the reaction [Colforsin results in increased secretion of GAST protein]
2',5'-dideoxyadenosine inhibits the reaction [Colforsin results in increased secretion of GAST protein]		 CTD PMID:9277405 PMID:19208342 NCBI chr10:88,245,532...88,248,485
Ensembl chr10:88,245,532...88,248,484 		JBrowse link
G Gcg glucagon multiple interactions
increases secretion		 EXP Colforsin promotes the reaction [Pyruvic Acid results in increased secretion of GCG protein]
Colforsin results in increased secretion of GCG protein		 CTD PMID:15919803 NCBI chr 3:48,442,635...48,451,650
Ensembl chr 3:48,442,635...48,451,650 		JBrowse link
G Gcm1 glial cells missing transcription factor 1 multiple interactions
decreases expression		 ISO Colforsin promotes the reaction [GCM1 protein binds to CREBBP protein]; Colforsin results in increased acetylation of and results in increased activity of GCM1 protein; CREBBP protein affects the reaction [Colforsin results in increased activity of GCM1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased activity of GCM1 protein]; trichostatin A promotes the reaction [Colforsin results in increased acetylation of and results in increased activity of GCM1 protein]
Colforsin results in decreased expression of GCM1 mRNA		 CTD PMID:16166624 PMID:31278978 NCBI chr 8:85,355,766...85,369,002
Ensembl chr 8:85,355,766...85,369,002 		JBrowse link
G Gh1 growth hormone 1 increases secretion
multiple interactions		 ISO
EXP		 Colforsin results in increased secretion of GH1 protein
GH1 protein promotes the reaction [Colforsin results in increased metabolism of Lipids]		 CTD PMID:14981226 PMID:19952226 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180 		JBrowse link
G Gli2 GLI family zinc finger 2 multiple interactions EXP Colforsin inhibits the reaction [Carbon Tetrachloride results in increased expression of GLI2 mRNA] CTD PMID:27590029 NCBI chr13:34,829,021...35,049,172
Ensembl chr13:34,829,139...35,048,444 		JBrowse link
G Gnai3 G protein subunit alpha i3 increases expression ISO Colforsin results in increased expression of GNAI3 mRNA CTD PMID:16751804 NCBI chr 2:210,896,779...210,934,733
Ensembl chr 2:210,896,656...210,934,749 		JBrowse link
G Gpbar1 G protein-coupled bile acid receptor 1 multiple interactions ISO [Colforsin binds to and results in increased activity of GPBAR1 protein] which results in increased abundance of Cyclic AMP; Colforsin binds to and results in increased activity of GPBAR1 protein CTD PMID:17963371 NCBI chr 9:81,555,914...81,560,931
Ensembl chr 9:81,559,605...81,560,594 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 increases phosphorylation
multiple interactions		 EXP Colforsin results in increased phosphorylation of GRIN1 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of GRIN1 protein]		 CTD PMID:14622123 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions
increases expression		 EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of GRIN2B protein]
Colforsin results in increased expression of GRIN2B mRNA; Colforsin results in increased expression of GRIN2B protein		 CTD PMID:20067577 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP Colforsin results in increased phosphorylation of and results in decreased activity of GSK3B protein CTD PMID:15950778 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268 		JBrowse link
G Hamp hepcidin antimicrobial peptide affects expression
multiple interactions		 ISO Colforsin affects the expression of HAMP mRNA
Colforsin inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]		 CTD PMID:25633564 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960 		JBrowse link
G Hcar2 hydroxycarboxylic acid receptor 2 multiple interactions ISO [3-Hydroxybutyric Acid results in increased activity of HCAR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; [Niacin results in increased activity of HCAR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; [Nicotinic Acids binds to and results in increased activity of HCAR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; Pertussis Toxin inhibits the reaction [[Nicotinic Acids binds to and results in increased activity of HCAR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]] CTD PMID:17124637 PMID:19223991 NCBI chr12:38,160,464...38,161,546
Ensembl chr12:38,160,464...38,161,546 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase affects expression
increases expression
multiple interactions		 ISO Colforsin affects the expression of HMGCR mRNA
Colforsin results in increased expression of HMGCR mRNA
[Colforsin co-treated with Ketoconazole] results in decreased expression of HMGCR mRNA; [Colforsin co-treated with triptolide] results in decreased expression of HMGCR mRNA; AR protein promotes the reaction [Colforsin results in increased expression of HMGCR protein]; Colforsin inhibits the reaction [Caffeine results in increased expression of HMGCR mRNA]; Valproic Acid affects the reaction [Colforsin affects the expression of HMGCR mRNA]		 CTD PMID:16751804 PMID:16935330 PMID:20726872 PMID:30825513 PMID:31557376 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 multiple interactions ISO Colforsin inhibits the reaction [Caffeine results in increased expression of HMGCS1 mRNA] CTD PMID:30825513 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO
EXP		 Colforsin results in increased expression of HMOX1 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of HMOX1 protein]
Colforsin results in increased expression of HMOX1 mRNA; Colforsin results in increased expression of HMOX1 protein		 CTD PMID:15179140 PMID:16439612 PMID:19483313 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 multiple interactions EXP HNRNPA1 mutant form inhibits the reaction [Colforsin affects the splicing of RUNX1 exon]; HNRNPA1 mutant form inhibits the reaction [Colforsin affects the splicing of SNAP25 exon] CTD PMID:22684629 NCBI chr 7:144,865,302...144,871,592
Ensembl chr 7:144,865,608...144,871,585 		JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K multiple interactions EXP Colforsin promotes the reaction [HNRNPK protein binds to SNAP25 exon] CTD PMID:22684629 NCBI chr17:6,664,730...6,676,753
Ensembl chr17:6,665,659...6,676,654 		JBrowse link
G Hrh2 histamine receptor H 2 multiple interactions ISO Dimaprit inhibits the reaction [HRH2 protein promotes the reaction [Colforsin results in increased abundance of Cyclic AMP]]; HRH2 protein promotes the reaction [Colforsin results in increased abundance of Cyclic AMP] CTD PMID:9187264 NCBI chr17:10,912,959...10,931,389
Ensembl chr17:10,921,507...10,952,441 		JBrowse link
G Hrh3 histamine receptor H3 multiple interactions EXP [imetit results in increased activity of HRH3 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; ciproxifan inhibits the reaction [[imetit results in increased activity of HRH3 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]; Pertussis Toxin inhibits the reaction [[imetit results in increased activity of HRH3 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]; thioperamide inhibits the reaction [[imetit results in increased activity of HRH3 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]] CTD PMID:21276809 NCBI chr 3:175,474,310...175,479,395
Ensembl chr 3:175,473,078...175,479,395 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions
increases expression		 ISO Colforsin inhibits the reaction [1,7-dimethylxanthine results in decreased expression of and results in decreased activity of HSD11B2 protein]; Colforsin inhibits the reaction [1,7-dimethylxanthine results in decreased expression of HSD11B2 mRNA]; Colforsin inhibits the reaction [Caffeine results in decreased expression of and results in decreased activity of HSD11B2 protein]; Colforsin inhibits the reaction [Caffeine results in decreased expression of HSD11B2 mRNA]; Colforsin inhibits the reaction [Ethanol results in decreased expression of HSD11B2 mRNA]; Colforsin inhibits the reaction [Ethanol results in decreased expression of HSD11B2 protein]; Ethanol inhibits the reaction [Colforsin results in increased expression of HSD11B2 mRNA]; Ethanol inhibits the reaction [Colforsin results in increased expression of HSD11B2 protein]
Colforsin results in increased expression of HSD11B2 mRNA; Colforsin results in increased expression of HSD11B2 protein		 CTD PMID:22701600 PMID:24361490 PMID:29802914 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307 		JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 affects expression
increases expression
multiple interactions		 ISO Colforsin affects the expression of HSD17B1 mRNA
Colforsin results in increased expression of HSD17B1 mRNA
[Colforsin co-treated with Aminoglutethimide] results in decreased expression of HSD17B1 mRNA; [Colforsin co-treated with Metyrapone] results in decreased expression of HSD17B1 mRNA; Valproic Acid affects the reaction [Colforsin affects the expression of HSD17B1 mRNA]		 CTD PMID:16935330 PMID:20726872 PMID:22446829 NCBI chr10:88,987,558...88,989,758
Ensembl chr10:88,987,558...88,989,757 		JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 increases expression ISO Colforsin results in increased expression of HSD17B3 mRNA CTD PMID:22461451 NCBI chr17:1,579,319...1,610,745
Ensembl chr17:1,579,319...1,610,745 		JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 affects expression
multiple interactions
increases expression		 ISO Colforsin affects the expression of HSD17B4 mRNA
Aminoglutethimide inhibits the reaction [Colforsin results in increased expression of HSD17B4 mRNA]; Ketoconazole promotes the reaction [Colforsin results in increased expression of HSD17B4 mRNA]; Valproic Acid affects the reaction [Colforsin affects the expression of HSD17B4 mRNA]		 CTD PMID:16935330 PMID:20726872 PMID:22446829 NCBI chr18:44,810,462...44,897,677
Ensembl chr18:44,810,388...44,897,640 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions ISO BMP6 protein inhibits the reaction [Colforsin results in increased expression of HSD3B1 mRNA] CTD PMID:18936084
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 increases expression
multiple interactions		 ISO Colforsin results in increased expression of HSD3B2 mRNA
[Colforsin co-treated with Ketoconazole] results in decreased expression of HSD3B2 mRNA; [Colforsin co-treated with Metyrapone] results in decreased expression of HSD3B2 mRNA; [Colforsin co-treated with triptolide] results in decreased expression of HSD3B2 mRNA; Apigenin inhibits the reaction [Colforsin results in increased expression of HSD3B2 mRNA]; daidzein inhibits the reaction [Colforsin results in increased expression of HSD3B2 mRNA]; Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of HSD3B2 mRNA]; Valproic Acid inhibits the reaction [Colforsin results in increased expression of HSD3B2 mRNA]		 CTD PMID:16935330 PMID:17080404 PMID:20726872 PMID:21256172 PMID:22446829 PMID:23370353 PMID:25765474 PMID:25871633 PMID:28235592 PMID:31100596 PMID:31557376 NCBI chr 2:200,712,895...200,722,429
Ensembl chr 2:202,341,422...202,350,929 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases response to substance ISO HSPA5 protein results in increased susceptibility to Colforsin CTD PMID:22912664 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions ISO [EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of HSPD1 mRNA; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of HSPD1 mRNA] CTD PMID:32092105 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions ISO [JB-788 binds to and results in increased activity of HTR1A protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; Arachidonic Acid metabolite inhibits the reaction [HTR1A protein inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]; HTR1A protein inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; Melitten inhibits the reaction [HTR1A protein inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]] CTD PMID:11356925 PMID:20580787 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896 		JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B multiple interactions ISO HTR1B affects the reaction [almotriptan inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]] CTD PMID:11134654 NCBI chr 8:89,113,984...89,130,830
Ensembl chr 8:89,129,453...89,130,991 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions EXP Colforsin inhibits the reaction [N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of HTR2A mRNA] CTD PMID:22791651 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382 		JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 multiple interactions ISO [Bromocriptine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; [Lisuride binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; [Metergoline binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; [Methiothepin binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; [Paliperidone Palmitate binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; [Risperidone binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP] CTD PMID:19509219 NCBI chr 1:254,547,964...254,671,811
Ensembl chr 1:254,547,620...254,671,778 		JBrowse link
G Iapp islet amyloid polypeptide increases expression EXP Colforsin results in increased expression of IAPP mRNA CTD PMID:9142872 NCBI chr 4:176,509,863...176,517,903
Ensembl chr 4:176,510,696...176,516,083 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Colforsin inhibits the reaction [Reactive Oxygen Species results in increased expression of ICAM1 mRNA]; Colforsin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA] CTD PMID:10495789 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Icam2 intercellular adhesion molecule 2 multiple interactions ISO Colforsin inhibits the reaction [EDN1 protein results in increased expression of ICAM2 mRNA] CTD PMID:25194819 NCBI chr10:94,569,889...94,581,218
Ensembl chr10:94,569,890...94,576,512 		JBrowse link
G Ier3 immediate early response 3 affects response to substance ISO IER3 protein affects the susceptibility to Colforsin CTD PMID:20713914 NCBI chr20:3,438,798...3,440,002
Ensembl chr20:3,438,798...3,440,769 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Colforsin inhibits the reaction [IFNG protein promotes the reaction [decitabine results in increased expression of PLA2G2A protein]] CTD PMID:18953428 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO Colforsin promotes the reaction [IGF1 protein results in increased abundance of Estradiol]; FGF9 protein inhibits the reaction [Colforsin promotes the reaction [IGF1 protein results in increased abundance of Estradiol]]; FGF9 protein inhibits the reaction [IGF1 protein promotes the reaction [Colforsin results in increased abundance of Progesterone]]; IGF1 protein promotes the reaction [Colforsin results in increased abundance of Progesterone] CTD PMID:22798350 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression
multiple interactions		 ISO Colforsin results in increased expression of IGFBP1
[Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased expression of IGFBP1 mRNA		 CTD PMID:12093828 PMID:31154070 NCBI chr14:87,448,716...87,453,783
Ensembl chr14:87,448,692...87,453,785 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO Colforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IKBKB mRNA] CTD PMID:17407152 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815 		JBrowse link
G Il10 interleukin 10 decreases expression ISO Colforsin results in decreased expression of IL10 protein CTD PMID:10996031 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il11 interleukin 11 increases expression ISO Colforsin results in increased expression of IL11 mRNA CTD PMID:22138297 NCBI chr 1:72,636,959...72,643,255
Ensembl chr 1:72,635,267...72,643,255 		JBrowse link
G Il12a interleukin 12A decreases expression ISO Colforsin results in decreased expression of IL12A protein CTD PMID:10996031 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318 		JBrowse link
G Il12b interleukin 12B multiple interactions
increases expression		 ISO Colforsin inhibits the reaction [oxophenylarsine promotes the reaction [Lipopolysaccharides results in increased expression of IL12B protein]]; Colforsin results in increased expression of [IL12B protein binds to IL23A protein]
Colforsin results in increased expression of IL12B protein		 CTD PMID:10996031 PMID:15180965 PMID:20512473 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085 		JBrowse link
G Il13 interleukin 13 decreases secretion
decreases expression		 ISO Colforsin results in decreased secretion of IL13 protein
Colforsin results in decreased expression of IL13 mRNA		 CTD PMID:16083514 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 Colforsin promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]
Colforsin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]		 CTD PMID:11112151 PMID:27590029 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il23a interleukin 23 subunit alpha increases expression
multiple interactions		 ISO Colforsin results in increased expression of IL23A protein
Colforsin results in increased expression of [IL12B protein binds to IL23A protein]		 CTD PMID:15180965 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha decreases expression ISO Colforsin results in decreased expression of IL2RA protein CTD PMID:1709825 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO Colforsin inhibits the reaction [Itraconazole results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [Itraconazole results in decreased secretion of IL4 protein]; Colforsin inhibits the reaction [Ketoconazole results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [Ketoconazole results in decreased secretion of IL4 protein]; Colforsin inhibits the reaction [Miconazole results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [Miconazole results in decreased secretion of IL4 protein]; Colforsin inhibits the reaction [terbinafine results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [terbinafine results in decreased secretion of IL4 protein]; Colforsin inhibits the reaction [Tolnaftate results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [Tolnaftate results in decreased secretion of IL4 protein] CTD PMID:11886533 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531 		JBrowse link
G Il5 interleukin 5 multiple interactions ISO Colforsin inhibits the reaction [Itraconazole results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Itraconazole results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [Ketoconazole results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Ketoconazole results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [Miconazole results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Miconazole results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [terbinafine results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [terbinafine results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [Tolnaftate results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Tolnaftate results in decreased secretion of IL5 protein] CTD PMID:11886533 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases secretion		 EXP
ISO		 Colforsin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
Colforsin inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]; Colforsin promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Colforsin promotes the reaction [TNF protein results in increased expression of IL6 mRNA]
Colforsin results in increased secretion of IL6 protein
oxophenylarsine inhibits the reaction [Colforsin results in increased secretion of IL6 protein]		 CTD PMID:17141199 PMID:20388727 PMID:21803157 PMID:24771768 PMID:25633564 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Inhba inhibin subunit beta A multiple interactions ISO FST protein inhibits the reaction [INHBA protein inhibits the reaction [Colforsin results in increased secretion of Progesterone]]; INHBA protein inhibits the reaction [Colforsin results in increased secretion of Progesterone] CTD PMID:18936084 NCBI chr17:51,894,869...51,919,998
Ensembl chr17:51,898,217...51,912,496 		JBrowse link
G Insig1 insulin induced gene 1 multiple interactions
increases expression		 ISO AR protein promotes the reaction [Colforsin results in increased expression of INSIG1 protein]
Colforsin results in increased expression of INSIG1 mRNA; Colforsin results in increased expression of INSIG1 protein		 CTD PMID:16751804 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO Colforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IRS1 mRNA] CTD PMID:17407152 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488 		JBrowse link
G Itga1 integrin subunit alpha 1 affects response to substance EXP ITGA1 protein affects the susceptibility to Colforsin CTD PMID:15836982 NCBI chr 2:47,127,403...47,281,387
Ensembl chr 2:47,127,219...47,281,421 		JBrowse link
G Itga3 integrin subunit alpha 3 affects response to substance EXP ITGA3 protein affects the susceptibility to Colforsin CTD PMID:15836982 NCBI chr10:82,855,841...82,887,755
Ensembl chr10:82,855,613...82,887,497 		JBrowse link
G Itgb1 integrin subunit beta 1 affects response to substance EXP ITGB1 protein affects the susceptibility to Colforsin CTD PMID:15836982 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535 		JBrowse link
G Itgb5 integrin subunit beta 5 increases expression ISO Colforsin results in increased expression of ITGB5 mRNA CTD PMID:16751804 NCBI chr11:70,056,500...70,172,164
Ensembl chr11:70,056,500...70,172,372 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of [ADRB1 protein binds to ADRB2 protein]] affects the reaction [KCNH2 protein results in increased transport of Potassium] CTD PMID:19419905 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253 		JBrowse link
G Lep leptin decreases expression
decreases secretion
multiple interactions		 ISO Colforsin results in decreased expression of LEP mRNA
Colforsin results in decreased secretion of LEP protein
Colforsin inhibits the reaction [Caffeine results in decreased expression of LEP mRNA]		 CTD PMID:9002984 PMID:26367767 PMID:27381457 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818 		JBrowse link
G Lhb luteinizing hormone subunit beta increases expression
multiple interactions		 EXP Colforsin results in increased expression of LHB protein
[Colforsin co-treated with CGB3 protein] results in increased chemical synthesis of Cyclic AMP; [Colforsin co-treated with CGB3 protein] results in increased chemical synthesis of Testosterone; CRH protein inhibits the reaction [[Colforsin co-treated with CGB3 protein] results in increased chemical synthesis of Cyclic AMP]; CRH protein inhibits the reaction [[Colforsin co-treated with CGB3 protein] results in increased chemical synthesis of Testosterone]; Tetradecanoylphorbol Acetate inhibits the reaction [[Colforsin co-treated with CGB3 protein] results in increased chemical synthesis of Cyclic AMP]; Tetradecanoylphorbol Acetate inhibits the reaction [[Colforsin co-treated with CGB3 protein] results in increased chemical synthesis of Testosterone]		 CTD PMID:2153673 PMID:8404651 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724 		JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor multiple interactions ISO [Colforsin co-treated with deoxynivalenol] results in increased expression of LHCGR mRNA; [Colforsin co-treated with Zearalenone] results in increased expression of LHCGR mRNA CTD PMID:26783879 NCBI chr 6:12,493,182...12,554,482
Ensembl chr 6:12,493,943...12,554,439 		JBrowse link
G Lipe lipase E, hormone sensitive type affects localization EXP Colforsin affects the localization of LIPE protein CTD PMID:11160373 NCBI chr 1:82,248,031...82,266,727
Ensembl chr 1:82,248,046...82,266,727 		JBrowse link
G Lpl lipoprotein lipase increases expression EXP Colforsin results in increased expression of LPL mRNA CTD PMID:9032464 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496 		JBrowse link
G Ltbp2 latent transforming growth factor beta binding protein 2 decreases expression ISO Colforsin results in decreased expression of LTBP2 mRNA CTD PMID:15313392 NCBI chr 6:108,500,114...108,596,653
Ensembl chr 6:108,500,112...108,596,569 		JBrowse link
G Ltc4s leukotriene C4 synthase decreases secretion ISO Colforsin results in decreased secretion of LTC4S protein CTD PMID:16083514 NCBI chr10:35,736,486...35,743,088
Ensembl chr10:35,737,664...35,739,625 		JBrowse link
G Lyz2 lysozyme 2 multiple interactions
decreases secretion
increases secretion		 ISO 3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone inhibits the reaction [Colforsin results in increased secretion of LYZ protein]; [Thapsigargin co-treated with Colforsin] results in increased secretion of LYZ protein
Colforsin results in decreased secretion of LYZ protein		 CTD PMID:15194485 PMID:15234967 NCBI chr 7:60,335,968...60,341,264
Ensembl chr 7:60,335,969...60,341,264 		JBrowse link
G Maf MAF bZIP transcription factor decreases expression ISO Colforsin results in decreased expression of MAF mRNA CTD PMID:16751804 NCBI chr19:48,179,826...48,200,995
Ensembl chr19:48,194,804...48,196,748 		JBrowse link
G Map7 microtubule-associated protein 7 increases expression ISO Colforsin results in increased expression of MAP7 mRNA CTD PMID:16751804 NCBI chr 1:15,620,665...15,748,203
Ensembl chr 1:15,620,653...15,748,203 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
increases activity		 ISO
EXP		 Colforsin inhibits the reaction [FGF10 protein results in increased phosphorylation of MAPK1 protein]; Colforsin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Colforsin inhibits the reaction [Shiga Toxin results in increased activity of MAPK1 protein]
1-Methyl-3-isobutylxanthine promotes the reaction [Colforsin inhibits the reaction [Testosterone results in increased phosphorylation of MAPK1 protein]]; Colforsin inhibits the reaction [Testosterone results in increased phosphorylation of MAPK1 protein]; Colforsin promotes the reaction [1-Methyl-3-isobutylxanthine inhibits the reaction [Testosterone results in increased phosphorylation of MAPK1 protein]]; Colforsin promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin promotes the reaction [1-Methyl-3-isobutylxanthine inhibits the reaction [Testosterone results in increased phosphorylation of MAPK1 protein]]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of MAPK1 protein]; Propranolol inhibits the reaction [Colforsin results in increased activity of MAPK1 protein]; Tetradecanoylphorbol Acetate promotes the reaction [Colforsin results in increased phosphorylation of MAPK1 protein]		 CTD PMID:11093795 PMID:11675405 PMID:12533312 PMID:14975937 PMID:15385614 PMID:17322281 PMID:18004999 PMID:20378682 PMID:21177760 PMID:22875961 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
increases activity
multiple interactions		 ISO
EXP		 Colforsin results in increased phosphorylation of MAPK3 protein
Colforsin results in increased activity of MAPK3 protein
1-Methyl-3-isobutylxanthine promotes the reaction [Colforsin inhibits the reaction [Testosterone results in increased phosphorylation of MAPK3 protein]]; Colforsin inhibits the reaction [Testosterone results in increased phosphorylation of MAPK3 protein]; Colforsin promotes the reaction [1-Methyl-3-isobutylxanthine inhibits the reaction [Testosterone results in increased phosphorylation of MAPK3 protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin promotes the reaction [1-Methyl-3-isobutylxanthine inhibits the reaction [Testosterone results in increased phosphorylation of MAPK3 protein]]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of MAPK3 protein]; Propranolol inhibits the reaction [Colforsin results in increased activity of MAPK3 protein]
Colforsin inhibits the reaction [FGF10 protein results in increased phosphorylation of MAPK3 protein]; Colforsin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; Colforsin inhibits the reaction [Shiga Toxin results in increased activity of MAPK3 protein]		 CTD PMID:11093795 PMID:11675405 PMID:12533312 PMID:14975937 PMID:15385614 PMID:17322281 PMID:18004999 PMID:20378682 PMID:21177760 PMID:22875961 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mc2r melanocortin 2 receptor multiple interactions
increases expression		 ISO Valproic Acid inhibits the reaction [Colforsin results in increased expression of MC2R mRNA] CTD PMID:20726872 PMID:25765474 NCBI chr18:64,166,959...64,178,729
Ensembl chr18:64,167,191...64,177,729 		JBrowse link
G Med28 mediator complex subunit 28 increases expression ISO Colforsin results in increased expression of MED28 mRNA CTD PMID:16751804 NCBI chr14:70,089,225...70,098,021
Ensembl chr14:70,089,225...70,098,021 		JBrowse link
G Mir190 microRNA 190 multiple interactions ISO Colforsin inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA] CTD PMID:24334028 NCBI chr 8:73,030,047...73,030,131
Ensembl chr 8:73,030,047...73,030,131 		JBrowse link
G Mitf melanocyte inducing transcription factor increases expression ISO Colforsin results in increased expression of MITF mRNA; Colforsin results in increased expression of MITF protein CTD PMID:17460731 PMID:28601556 NCBI chr 4:130,172,484...130,425,496
Ensembl chr 4:130,172,727...130,425,532 		JBrowse link
G Mmp16 matrix metallopeptidase 16 increases expression ISO Colforsin results in increased expression of MMP16 mRNA CTD PMID:16751804 NCBI chr 5:31,568,344...31,818,368
Ensembl chr 5:31,568,419...31,810,484 		JBrowse link
G Mterf4 mitochondrial transcription termination factor 4 decreases expression ISO Colforsin results in decreased expression of MTERF4 mRNA CTD PMID:16751804 NCBI chr 9:100,440,482...100,445,158
Ensembl chr 9:100,440,486...100,445,158 		JBrowse link
G Muc4 mucin 4, cell surface associated increases expression ISO Colforsin results in increased expression of MUC4 protein CTD PMID:28049186 NCBI chr11:71,242,973...71,285,217
Ensembl chr11:71,243,334...71,284,939 		JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions EXP Colforsin inhibits the reaction [Dinoprostone results in increased expression of MYH7 protein]; Colforsin inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA] CTD PMID:18851973 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089 		JBrowse link
G Nav1 neuron navigator 1 decreases expression ISO Colforsin results in decreased expression of NAV1 mRNA CTD PMID:16751804 NCBI chr13:52,260,474...52,515,016
Ensembl chr13:52,267,254...52,514,875 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Colforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NFKB1 mRNA] CTD PMID:17407152 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Ngf nerve growth factor multiple interactions
increases expression		 EXP [Colforsin results in increased abundance of Cyclic AMP] which results in increased expression of NGF mRNA
Colforsin results in increased expression of NGF mRNA		 CTD PMID:2174743 PMID:2853697 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453 		JBrowse link
G Ngly1 N-glycanase 1 increases expression ISO Colforsin results in increased expression of NGLY1 mRNA CTD PMID:16751804 NCBI chr15:10,405,453...10,455,973
Ensembl chr15:10,405,164...10,455,956 		JBrowse link
G Nmu neuromedin U increases expression EXP Colforsin results in increased expression of NMU mRNA CTD PMID:23423171 NCBI chr14:34,353,683...34,381,968
Ensembl chr14:34,354,503...34,381,828 		JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP Colforsin inhibits the reaction [Dinoprostone results in increased expression of NPPA protein]; Colforsin inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:11470465 PMID:18851973 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705 		JBrowse link
G Nr0b1 nuclear receptor subfamily 0, group B, member 1 decreases expression
multiple interactions		 ISO Colforsin results in decreased expression of NR0B1 mRNA
Valproic Acid inhibits the reaction [Colforsin results in decreased expression of NR0B1 mRNA]		 CTD PMID:20726872 NCBI chr  X:54,734,385...54,738,513
Ensembl chr  X:54,734,385...54,738,513 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
decreases expression		 EXP
ISO		 Colforsin results in increased activity of NR1I2 protein
Colforsin results in decreased expression of NR1I2 mRNA		 CTD PMID:27732639 PMID:29933105 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases activity ISO Colforsin results in increased activity of NR3C1 protein CTD PMID:19255438 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression
multiple interactions		 ISO Colforsin results in increased expression of NR4A1 mRNA; Colforsin results in increased expression of NR4A1 protein
[Colforsin co-treated with deoxynivalenol] results in increased expression of NR4A1 mRNA; Colforsin promotes the reaction [Zearalenone results in increased expression of NR4A1 mRNA]; NR4A1 protein inhibits the reaction [Ryanodine inhibits the reaction [Colforsin results in increased expression of STAR protein]]; Ryanodine inhibits the reaction [Colforsin results in increased expression of NR4A1 mRNA]; Ryanodine inhibits the reaction [Colforsin results in increased expression of NR4A1 protein]; W 7 inhibits the reaction [Colforsin results in increased expression of NR4A1 mRNA]; W 7 inhibits the reaction [Colforsin results in increased expression of NR4A1 protein]
NR4A1 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]		 CTD PMID:8164692 PMID:19822197 PMID:23183170 PMID:26783879 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 multiple interactions
increases expression		 ISO NR4A2 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]
Colforsin results in increased expression of NR4A2 protein		 CTD PMID:19732956 PMID:19822197 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159 		JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 multiple interactions ISO NR4A3 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA] CTD PMID:19822197 NCBI chr 5:63,781,801...63,822,890
Ensembl chr 5:63,781,801...63,821,637 		JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 affects expression ISO Colforsin affects the expression of NR5A1 mRNA CTD PMID:20726872 NCBI chr 3:22,998,900...23,020,441
Ensembl chr 3:22,999,616...23,020,441 		JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 multiple interactions
increases expression		 ISO alitretinoin inhibits the reaction [NR5A2 protein promotes the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP19A1 mRNA]]; NR5A2 protein promotes the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP19A1 mRNA]
Colforsin results in increased expression of NR5A2 mRNA		 CTD PMID:16357189 NCBI chr13:53,750,470...53,870,288
Ensembl chr13:53,750,473...53,870,428 		JBrowse link
G Nrg1 neuregulin 1 multiple interactions ISO [Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of NRG1 mRNA; U 0126 inhibits the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of NRG1 mRNA] CTD PMID:21047912 NCBI chr16:62,969,573...64,065,063
Ensembl chr16:63,837,216...64,057,434 		JBrowse link
G Ntf3 neurotrophin 3 increases expression EXP Colforsin results in increased expression of NTF3 protein CTD PMID:19854260 NCBI chr 4:158,636,883...158,705,886
Ensembl chr 4:158,636,884...158,705,886 		JBrowse link
G Numa1 nuclear mitotic apparatus protein 1 decreases expression ISO Colforsin results in decreased expression of NUMA1 mRNA CTD PMID:16751804 NCBI chr 1:167,044,544...167,091,453
Ensembl chr 1:167,051,209...167,091,453 		JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide multiple interactions ISO BMP6 protein inhibits the reaction [Colforsin results in increased expression of OXT mRNA] CTD PMID:18936084 NCBI chr 3:123,106,694...123,107,534
Ensembl chr 3:123,106,694...123,107,534 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 ISO [Colforsin co-treated with Theophylline] inhibits the reaction [Etoposide results in increased cleavage of PARP1 protein]
Colforsin results in increased cleavage of PARP1 protein		 CTD PMID:9454737 PMID:31278978 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Pax8 paired box 8 increases expression ISO Colforsin results in increased expression of PAX8 mRNA; Colforsin results in increased expression of PAX8 protein CTD PMID:15961562 NCBI chr 3:1,527,316...1,586,019
Ensembl chr 3:1,527,279...1,584,946 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression
multiple interactions		 EXP
ISO		 Colforsin results in increased expression of PCK1 mRNA
Colforsin inhibits the reaction [Leflunomide results in increased expression of PCK1 mRNA]; Colforsin inhibits the reaction [teriflunomide results in increased expression of PCK1 mRNA]
Dexamethasone promotes the reaction [Colforsin results in increased expression of PCK1 mRNA]		 CTD PMID:25851902 PMID:30364229 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871 		JBrowse link
G Pde1b phosphodiesterase 1B multiple interactions ISO PDE1B protein affects the reaction [Colforsin results in increased phosphorylation of PPP1R1B protein] CTD PMID:12077213 NCBI chr 7:145,117,951...145,147,711
Ensembl chr 7:145,117,951...145,145,376 		JBrowse link
G Pde2a phosphodiesterase 2A multiple interactions ISO PDE2A protein inhibits the reaction [Colforsin affects the localization of AHR protein] CTD PMID:17329248 NCBI chr 1:166,534,643...166,626,158
Ensembl chr 1:166,534,643...166,626,158 		JBrowse link
G Pde4b phosphodiesterase 4B increases expression ISO Colforsin results in increased expression of PDE4B mRNA CTD PMID:15967414 NCBI chr 5:121,759,236...122,136,814
Ensembl chr 5:121,952,977...122,136,814 		JBrowse link
G Pde4d phosphodiesterase 4D increases expression ISO Colforsin results in increased expression of PDE4D mRNA CTD PMID:15967414 NCBI chr 2:40,219,999...41,468,551
Ensembl chr 2:40,554,146...41,464,264 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 affects response to substance
multiple interactions		 ISO PDK1 protein affects the susceptibility to Colforsin
[PDK1 protein affects the susceptibility to Colforsin] which affects the abundance of Cyclic AMP; tubacin affects the reaction [[PDK1 protein affects the susceptibility to Colforsin] which affects the abundance of Cyclic AMP]		 CTD PMID:28887310 NCBI chr 3:58,530,870...58,561,494
Ensembl chr 3:58,530,870...58,558,027 		JBrowse link
G Per1 period circadian regulator 1 multiple interactions
increases expression		 ISO [Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PER1 mRNA; AHR protein inhibits the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PER1 mRNA]; beta-Naphthoflavone inhibits the reaction [Colforsin results in increased expression of PER1 mRNA] CTD PMID:23291558 NCBI chr10:55,681,761...55,696,557
Ensembl chr10:55,687,050...55,695,994 		JBrowse link
G Pgr progesterone receptor increases expression ISO Colforsin results in increased expression of PGR mRNA CTD PMID:20378682 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796 		JBrowse link
G Pias1 protein inhibitor of activated STAT, 1 decreases expression ISO Colforsin results in decreased expression of PIAS1 mRNA CTD PMID:16751804 NCBI chr 8:67,771,720...67,869,015
Ensembl chr 8:67,771,720...67,869,019 		JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions ISO PINK1 protein affects the reaction [Colforsin results in decreased expression of DNM1L protein] CTD PMID:24792327 NCBI chr 5:156,677,146...156,689,258
Ensembl chr 5:156,677,146...156,689,415 		JBrowse link
G Pla2g2a phospholipase A2 group IIA multiple interactions ISO Colforsin inhibits the reaction [IFNG protein promotes the reaction [decitabine results in increased expression of PLA2G2A protein]] CTD PMID:18953428 NCBI chr 5:157,282,650...157,285,295
Ensembl chr 5:157,282,669...157,285,328 		JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 multiple interactions ISO PNPLA2 protein affects the reaction [Colforsin results in increased phosphorylation of and results in increased activity of PRKAA1 protein] CTD PMID:18390901 NCBI chr 1:214,434,638...214,439,720
Ensembl chr 1:214,434,626...214,439,720 		JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 multiple interactions
increases expression		 ISO 1-Methyl-3-isobutylxanthine promotes the reaction [Colforsin results in increased expression of and results in increased activity of PNPLA6 protein]; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PNPLA6 mRNA; Colforsin results in increased expression of and results in increased activity of PNPLA6 protein; Cycloheximide inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of PNPLA6 protein]; Cycloheximide inhibits the reaction [Colforsin results in increased activity of PNPLA6 protein]
Colforsin results in increased expression of PNPLA6 mRNA		 CTD PMID:20380879 NCBI chr12:2,068,749...2,098,139
Ensembl chr12:2,069,959...2,097,904 		JBrowse link
G Pou1f1 POU class 1 homeobox 1 multiple interactions EXP Colforsin promotes the reaction [CREB1 protein binds to POU1F1 promoter]; resveratrol inhibits the reaction [Colforsin promotes the reaction [CREB1 protein binds to POU1F1 promoter]] CTD PMID:23292070 NCBI chr11:2,645,659...2,662,581
Ensembl chr11:2,645,865...2,662,579 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO Colforsin results in decreased expression of PPARG mRNA CTD PMID:31278978 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Colforsin results in increased expression of PPARGC1A mRNA CTD PMID:16357189 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009 		JBrowse link
G Ppargc1b PPARG coactivator 1 beta increases expression ISO Colforsin results in increased expression of PPARGC1B mRNA CTD PMID:16357189 NCBI chr18:56,626,725...56,650,524
Ensembl chr18:56,626,712...56,728,968 		JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A increases phosphorylation
multiple interactions		 ISO Colforsin results in increased phosphorylation of PPP1R12A protein
Capsaicin inhibits the reaction [Colforsin results in increased phosphorylation of PPP1R12A protein]; capsazepine inhibits the reaction [Colforsin results in increased phosphorylation of PPP1R12A protein]		 CTD PMID:21474433 NCBI chr 7:51,404,971...51,515,382
Ensembl chr 7:51,404,919...51,515,373 		JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B increases phosphorylation
multiple interactions		 ISO Colforsin results in increased phosphorylation of PPP1R1B protein
PDE1B protein affects the reaction [Colforsin results in increased phosphorylation of PPP1R1B protein]		 CTD PMID:12077213 NCBI chr10:86,303,727...86,312,770
Ensembl chr10:86,303,727...86,312,762 		JBrowse link
G Prima1 proline rich membrane anchor 1 increases expression EXP Colforsin results in increased expression of PRIMA1 mRNA CTD PMID:18514641 NCBI chr 6:127,075,954...127,127,985
Ensembl chr 6:127,075,954...127,127,413 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions ISO Colforsin results in increased phosphorylation of and results in increased activity of PRKAA1 protein; PNPLA2 protein affects the reaction [Colforsin results in increased phosphorylation of and results in increased activity of PRKAA1 protein] CTD PMID:18390901 NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha multiple interactions
increases activity		 EXP
ISO		 Colforsin inhibits the reaction [Oxidopamine results in decreased phosphorylation of PRKACA protein]
Colforsin results in increased activity of PRKACA protein		 CTD PMID:16339297 PMID:28601556 NCBI chr19:25,095,089...25,118,869
Ensembl chr19:25,095,089...25,118,860 		JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta multiple interactions ISO [PRKACB protein mutant form results in increased susceptibility to [Colforsin co-treated with 1-Methyl-3-isobutylxanthine]] results in decreased stability of [PRKACB protein mutant form binds to PRKAR1A protein]; [PRKACB protein mutant form results in increased susceptibility to [Colforsin co-treated with 1-Methyl-3-isobutylxanthine]] results in decreased stability of [PRKACB protein mutant form binds to PRKAR1B protein]; PRKACB protein mutant form results in increased susceptibility to [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] CTD PMID:29669941 NCBI chr 2:252,602,197...252,691,886
Ensembl chr 2:252,605,307...252,691,886 		JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha multiple interactions ISO [PRKACB protein mutant form results in increased susceptibility to [Colforsin co-treated with 1-Methyl-3-isobutylxanthine]] results in decreased stability of [PRKACB protein mutant form binds to PRKAR1A protein] CTD PMID:29669941 NCBI chr10:97,940,705...97,959,199
Ensembl chr10:97,940,705...97,957,336 		JBrowse link
G Prkar1b protein kinase cAMP-dependent type I regulatory subunit beta multiple interactions ISO [PRKACB protein mutant form results in increased susceptibility to [Colforsin co-treated with 1-Methyl-3-isobutylxanthine]] results in decreased stability of [PRKACB protein mutant form binds to PRKAR1B protein] CTD PMID:29669941 NCBI chr12:17,614,536...17,713,567
Ensembl chr12:17,614,632...17,712,373 		JBrowse link
G Prkar2a protein kinase cAMP-dependent type II regulatory subunit alpha increases phosphorylation ISO Colforsin results in increased phosphorylation of PRKAR2A protein CTD PMID:25943029 NCBI chr 8:117,486,085...117,548,768
Ensembl chr 8:117,486,083...117,546,370 		JBrowse link
G Prl prolactin multiple interactions
increases expression		 EXP
ISO		 Colforsin inhibits the reaction [Octreotide results in decreased secretion of PRL protein]; Octreotide inhibits the reaction [Colforsin results in increased expression of PRL protein]
[Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased expression of PRL mRNA; [Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased secretion of PRL protein; Cannabidiol inhibits the reaction [[Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased expression of PRL mRNA]; Cannabidiol inhibits the reaction [[Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased secretion of PRL protein]; Cannabinol inhibits the reaction [[Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased expression of PRL mRNA]; Cannabinol inhibits the reaction [[Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased secretion of PRL protein]; Dronabinol inhibits the reaction [[Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased expression of PRL mRNA]; Dronabinol inhibits the reaction [[Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased secretion of PRL protein]; Rimonabant inhibits the reaction [Dronabinol inhibits the reaction [[Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased expression of PRL mRNA]]		 CTD PMID:1322274 PMID:31154070 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299 		JBrowse link
G Ptch1 patched 1 multiple interactions EXP Colforsin inhibits the reaction [Carbon Tetrachloride results in increased expression of PTCH1 mRNA] CTD PMID:27590029 NCBI chr17:1,032,242...1,085,885
Ensembl chr17:1,029,048...1,093,873 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 ISO
EXP		 Colforsin promotes the reaction [bisperoxovanadium results in increased expression of PTGS2 mRNA]; Colforsin promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]
Colforsin results in increased expression of PTGS2 mRNA
bifenthrin inhibits the reaction [Colforsin results in increased expression of PTGS2 mRNA]; Colforsin inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]
Colforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]; Colforsin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]		 CTD PMID:11112151 PMID:12493747 PMID:15213229 PMID:17407152 PMID:19063610 PMID:20378682 PMID:21251947 PMID:27590029 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rap1a RAP1A, member of RAS oncogene family increases activity
multiple interactions		 EXP Colforsin results in increased activity of RAP1A protein
Rolipram affects the reaction [Colforsin results in increased activity of RAP1A protein]		 CTD PMID:10908723 NCBI chr 2:208,193,950...208,215,186
Ensembl chr 2:208,193,954...208,215,187 		JBrowse link
G Rap1b RAP1B, member of RAS oncogene family multiple interactions
increases activity		 EXP Rolipram affects the reaction [Colforsin results in increased activity of RAP1B protein] CTD PMID:10908723 NCBI chr 7:60,850,406...60,878,226
Ensembl chr 7:60,853,930...60,860,990 		JBrowse link
G Rarres2 retinoic acid receptor responder 2 multiple interactions EXP RARRES2 protein inhibits the reaction [Colforsin results in increased expression of CYP11A1 protein]; RARRES2 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 protein] CTD PMID:22948218 NCBI chr 4:78,205,809...78,208,956
Ensembl chr 4:78,205,812...78,208,767 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO [Colforsin co-treated with Theophylline] inhibits the reaction [Etoposide results in decreased phosphorylation of RB1 protein] CTD PMID:9454737 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO		 Colforsin inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA protein]; Colforsin inhibits the reaction [Morphine results in increased phosphorylation of RELA protein]
RELA affects the reaction [[monobutyl phthalate co-treated with Colforsin] results in increased secretion of Progesterone]		 CTD PMID:22258905 PMID:26745512 PMID:27590029 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit multiple interactions ISO Colforsin promotes the reaction [[AHR protein binds to RELB protein] which binds to CXCL8 promoter]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin promotes the reaction [[AHR protein binds to RELB protein] which binds to CXCL8 promoter]] CTD PMID:17823304 NCBI chr 1:80,517,081...80,545,019
Ensembl chr 1:80,517,411...80,544,825 		JBrowse link
G Ren renin increases expression
multiple interactions
increases secretion		 ISO Colforsin results in increased expression of REN mRNA
[Sodium, Dietary deficiency results in increased susceptibility to Colforsin] which results in increased secretion of REN protein
Colforsin results in increased secretion of REN protein		 CTD PMID:9256163 PMID:10432392 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151 		JBrowse link
G Rnf4 ring finger protein 4 multiple interactions EXP [Tetradecanoylphorbol Acetate co-treated with Colforsin] results in increased expression of RNF4 mRNA CTD PMID:14749358 NCBI chr14:81,658,400...81,679,756
Ensembl chr14:81,660,354...81,679,082 		JBrowse link
G Rrp12 ribosomal RNA processing 12 homolog increases expression ISO Colforsin results in increased expression of RRP12 mRNA CTD PMID:16751804 NCBI chr 1:261,106,768...261,140,416
Ensembl chr 1:261,106,760...261,140,389 		JBrowse link
G Runx1 RUNX family transcription factor 1 affects splicing
multiple interactions		 EXP Colforsin affects the splicing of RUNX1 exon
HNRNPA1 mutant form inhibits the reaction [Colforsin affects the splicing of RUNX1 exon]		 CTD PMID:22684629 NCBI chr11:32,765,147...33,003,061
Ensembl chr11:32,769,165...33,003,021 		JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression EXP Colforsin results in increased expression of RUNX2 mRNA CTD PMID:20197312 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092 		JBrowse link
G Sele selectin E multiple interactions ISO [Colforsin co-treated with Rolipram] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SELE protein]; [Colforsin co-treated with Rolipram] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SELE protein]; [Colforsin co-treated with Rolipram] inhibits the reaction [TNF protein results in increased expression of SELE protein]; [Colforsin co-treated with Rolipram] inhibits the reaction [TNF protein results in increased secretion of SELE protein] CTD PMID:8780174 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341 		JBrowse link
G Selenop selenoprotein P multiple interactions EXP Colforsin promotes the reaction [Dexamethasone results in increased expression of SELENOP mRNA] CTD PMID:18972406 NCBI chr 2:53,105,912...53,116,198
Ensembl chr 2:53,109,684...53,114,858 		JBrowse link
G Sesn1 sestrin 1 decreases expression
multiple interactions		 ISO Colforsin results in decreased expression of SESN1 mRNA; Colforsin results in decreased expression of SESN1 protein
AR protein affects the reaction [Colforsin results in decreased expression of SESN1 protein]		 CTD PMID:16751804 NCBI chr20:46,667,116...46,758,306
Ensembl chr20:46,667,121...46,758,305 		JBrowse link
G Sftpc surfactant protein C increases expression ISO Colforsin results in increased expression of SFTPC mRNA CTD PMID:2539393 NCBI chr15:52,211,538...52,214,480
Ensembl chr15:52,211,544...52,214,616 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP
ISO		 SIRT1 mutant form inhibits the reaction [Resveratrol inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]]; SIRT1 protein inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]; SIRT1 protein mutant form inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]
Colforsin inhibits the reaction [Caffeine results in decreased expression of SIRT1 mRNA]		 CTD PMID:23292070 PMID:30825513 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199 		JBrowse link
G Slc26a4 solute carrier family 26 member 4 increases expression ISO Colforsin results in increased expression of SLC26A4 protein CTD PMID:22811483 NCBI chr 6:50,809,103...50,848,443
Ensembl chr 6:50,808,923...50,846,965 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO Colforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SLC2A4 mRNA] CTD PMID:17407152 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487 		JBrowse link
G Slc2a5 solute carrier family 2 member 5 multiple interactions
increases expression		 ISO
EXP		 Colforsin promotes the reaction [Fructose results in increased expression of SLC2A5 mRNA]; Colforsin promotes the reaction [Glucose results in increased expression of SLC2A5 mRNA]
[[Colforsin results in increased abundance of Cyclic AMP] which results in increased expression of SLC2A5 protein] which results in increased uptake of Fructose; [Colforsin results in increased abundance of Cyclic AMP] which results in increased expression of SLC2A5 protein; Colforsin results in increased expression of and results in decreased degradation of SLC2A5 mRNA
Colforsin results in increased expression of SLC2A5 mRNA		 CTD PMID:8037665 PMID:12820898 NCBI chr 5:167,142,182...167,174,203
Ensembl chr 5:167,141,875...167,174,310 		JBrowse link
G Slc30a1 solute carrier family 30 member 1 increases expression ISO Colforsin results in increased expression of SLC30A1 mRNA CTD PMID:16503475 NCBI chr13:110,677,810...110,681,683
Ensembl chr13:110,677,810...110,681,683 		JBrowse link
G Slc30a2 solute carrier family 30 member 2 increases expression ISO Colforsin results in increased expression of SLC30A2 mRNA CTD PMID:16503475 NCBI chr 5:152,559,577...152,571,800
Ensembl chr 5:152,559,577...152,571,799 		JBrowse link
G Slc30a4 solute carrier family 30 member 4 increases expression ISO Colforsin results in increased expression of SLC30A4 mRNA CTD PMID:16503475 NCBI chr 3:114,805,919...114,828,154
Ensembl chr 3:114,805,922...114,828,154 		JBrowse link
G Slc30a7 solute carrier family 30 member 7 decreases expression ISO Colforsin results in decreased expression of SLC30A7 mRNA CTD PMID:16751804 NCBI chr 2:218,888,431...218,951,030
Ensembl chr 2:218,888,431...218,951,030 		JBrowse link
G Slc45a2 solute carrier family 45, member 2 increases expression ISO Colforsin results in increased expression of SLC45A2 mRNA CTD PMID:17460731 NCBI chr 2:60,966,671...60,999,398
Ensembl chr 2:60,966,789...60,999,398 		JBrowse link
G Slc5a5 solute carrier family 5 member 5 multiple interactions
increases expression		 ISO
EXP		 Colforsin inhibits the reaction [[Tretinoin co-treated with Hydrocortisone] results in increased activity of SLC5A5 protein]
Colforsin results in increased expression of SLC5A5 mRNA; Colforsin results in increased expression of SLC5A5 protein		 CTD PMID:16439463 PMID:16954431 NCBI chr16:20,297,414...20,307,401
Ensembl chr16:20,297,414...20,307,400 		JBrowse link
G Smo smoothened, frizzled class receptor multiple interactions EXP Colforsin inhibits the reaction [Carbon Tetrachloride results in increased expression of SMO mRNA] CTD PMID:27590029 NCBI chr 4:57,019,941...57,041,779
Ensembl chr 4:57,019,941...57,042,770 		JBrowse link
G Snap25 synaptosome associated protein 25 affects splicing
multiple interactions		 EXP Colforsin affects the splicing of SNAP25 exon
Colforsin promotes the reaction [HNRNPK protein binds to SNAP25 exon]; HNRNPA1 mutant form inhibits the reaction [Colforsin affects the splicing of SNAP25 exon]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin affects the splicing of SNAP25 exon]		 CTD PMID:22684629 NCBI chr 3:129,697,408...129,788,417
Ensembl chr 3:129,599,353...129,788,400 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions
increases expression		 ISO Colforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA]
Colforsin results in increased expression of SOCS3 protein
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [[[Colforsin co-treated with Rolipram] results in increased abundance of Cyclic AMP] which results in increased expression of SOCS3 protein]; [[Colforsin co-treated with Rolipram] results in increased abundance of Cyclic AMP] which results in increased expression of SOCS3 protein; dorsomorphin inhibits the reaction [[[Colforsin co-treated with Rolipram] results in increased abundance of Cyclic AMP] which results in increased expression of SOCS3 protein]		 CTD PMID:17407152 PMID:23782265 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO [EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD1 mRNA; [EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD1 protein; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD1 mRNA]; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD1 protein] CTD PMID:32092105 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression
multiple interactions
increases activity		 ISO Colforsin results in increased expression of SOD2 mRNA
[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD2 mRNA; [EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD2 protein; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD2 protein]
Colforsin results in increased activity of SOD2 protein		 CTD PMID:12093828 PMID:32092105 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Spcs3 signal peptidase complex subunit 3 increases expression ISO Colforsin results in increased expression of SPCS3 mRNA CTD PMID:16751804 NCBI chr16:40,050,862...40,056,296
Ensembl chr16:40,050,734...40,058,822 		JBrowse link
G Sqstm1 sequestosome 1 increases degradation ISO Colforsin results in increased degradation of SQSTM1 protein CTD PMID:25943029 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294 		JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 increases expression ISO Colforsin results in increased expression of SRD5A1 mRNA CTD PMID:22461451 NCBI chr 1:36,320,504...36,354,694
Ensembl chr 1:36,320,461...36,354,756 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO Colforsin inhibits the reaction [Caffeine results in increased expression of SREBF2 mRNA] CTD PMID:30825513 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603 		JBrowse link
G Sst somatostatin multiple interactions ISO [SST protein co-treated with SSTR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP] CTD PMID:22056254 NCBI chr11:80,358,172...80,359,449
Ensembl chr11:80,358,211...80,359,444 		JBrowse link
G Sstr2 somatostatin receptor 2 multiple interactions ISO [64Cu-CB-TE2A-Y3-TATE co-treated with SSTR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]; [SST protein co-treated with SSTR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP] CTD PMID:22056254 NCBI chr10:102,136,283...102,143,449
Ensembl chr10:102,136,283...102,143,434 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions
increases expression		 ISO
EXP		 BMP6 protein inhibits the reaction [Colforsin results in increased expression of STAR mRNA]; Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of STAR mRNA]; Valproic Acid inhibits the reaction [Colforsin results in increased expression of STAR mRNA]
[Colforsin co-treated with deoxynivalenol] results in increased expression of STAR mRNA; Colforsin affects the reaction [Zearalenone results in increased expression of STAR mRNA]; NR4A1 protein inhibits the reaction [Ryanodine inhibits the reaction [Colforsin results in increased expression of STAR protein]]; Ryanodine inhibits the reaction [Colforsin results in increased expression of STAR mRNA]; Ryanodine inhibits the reaction [Colforsin results in increased expression of STAR protein]; W 7 inhibits the reaction [Colforsin results in increased expression of STAR mRNA]; W 7 inhibits the reaction [Colforsin results in increased expression of STAR protein]
Colforsin results in increased expression of STAR mRNA; Colforsin results in increased expression of STAR protein
[Atrazine co-treated with Colforsin] results in increased expression of STAR mRNA		 CTD PMID:14691014 PMID:15967414 PMID:16254025 PMID:16935330 PMID:17080404 PMID:18936084 PMID:20726872 PMID:22461451 PMID:23183170 PMID:25253736 PMID:25765474 PMID:25871633 PMID:26745512 PMID:26783879 PMID:28235592 PMID:28859905 PMID:31100596 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847 		JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 decreases expression ISO Colforsin results in decreased expression of SULT1E1 mRNA CTD PMID:22446829 NCBI chr14:22,070,861...22,089,264
Ensembl chr14:22,072,024...22,089,248 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 decreases expression
multiple interactions		 ISO Colforsin results in decreased expression of SULT2A1 mRNA
Hexachlorocyclohexane promotes the reaction [Colforsin results in decreased expression of SULT2A1 mRNA]		 CTD PMID:17080404 PMID:22446829 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230 		JBrowse link
G Sult2b1 sulfotransferase family 2B member 1 decreases expression ISO Colforsin results in decreased expression of SULT2B1 mRNA CTD PMID:22446829 NCBI chr 1:101,712,254...101,774,683
Ensembl chr 1:101,710,959...101,773,508 		JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP Colforsin promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]; HU 211 inhibits the reaction [Colforsin promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]] CTD PMID:15750287 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819 		JBrowse link
G Tbr1 T-box brain transcription factor 1 multiple interactions EXP Colforsin promotes the reaction [CASK protein modified form binds to TBR1 protein] CTD PMID:20067577 NCBI chr 3:47,677,720...47,685,902
Ensembl chr 3:47,677,720...47,685,902 		JBrowse link
G Testin testin gene affects expression EXP Colforsin affects the expression of TESTIN mRNA CTD PMID:11090432 NCBI chr17:4,194,796...4,225,376
Ensembl chr17:4,212,890...4,225,376 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO
EXP		 Colforsin inhibits the reaction [Dronabinol results in increased expression of TGFB1 protein]; TGFB1 protein inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]
Colforsin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]		 CTD PMID:11779138 PMID:15625562 PMID:27590029 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tgs1 trimethylguanosine synthase 1 increases expression ISO Colforsin results in increased expression of TGS1 mRNA CTD PMID:16751804 NCBI chr 5:16,413,356...16,446,881
Ensembl chr 5:16,413,356...16,446,881 		JBrowse link
G Th tyrosine hydroxylase multiple interactions
increases activity
increases expression		 EXP 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol inhibits the reaction [Colforsin results in increased expression of TH mRNA]; bisindolylmaleimide I inhibits the reaction [Colforsin results in increased expression of TH mRNA]; HU 211 inhibits the reaction [Colforsin results in increased expression of TH mRNA]; KT 5720 inhibits the reaction [Colforsin results in increased expression of TH mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of TH mRNA]
Colforsin results in increased activity of TH protein
Colforsin results in increased expression of TH mRNA; Colforsin results in increased expression of TH protein		 CTD PMID:9288946 PMID:14550852 PMID:18992715 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO Colforsin results in increased expression of TIMP1 mRNA CTD PMID:20378682 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions
increases expression		 EXP Colforsin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of TIMP2 protein]
Colforsin results in increased expression of TIMP2 protein		 CTD PMID:21832167 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072 		JBrowse link
G Tmem50a transmembrane protein 50A increases expression ISO Colforsin results in increased expression of TMEM50A mRNA CTD PMID:16751804 NCBI chr 5:153,233,965...153,252,006
Ensembl chr 5:153,233,962...153,252,021 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 ISO
EXP		 Colforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TNF mRNA]; Colforsin inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Colforsin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]
[Colforsin co-treated with Rolipram] inhibits the reaction [TNF protein results in increased expression of SELE protein]; [Colforsin co-treated with Rolipram] inhibits the reaction [TNF protein results in increased secretion of SELE protein]; Colforsin inhibits the reaction [3,4-dihydroxyphenylethanol promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; Colforsin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Colforsin inhibits the reaction [Shiga Toxin results in increased expression of TNF mRNA]; Colforsin promotes the reaction [TNF protein results in increased expression of IL6 mRNA]
Colforsin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Colforsin inhibits the reaction [Dopamine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]]; Colforsin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF protein]; Colforsin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Colforsin results in decreased expression of TNF protein		 CTD PMID:8780174 PMID:10495789 PMID:10996031 PMID:11675405 PMID:12509806 PMID:15081246 PMID:17407152 PMID:20388727 PMID:21803157 PMID:24771768 PMID:25866079 PMID:27590029 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tob1 transducer of ErbB-2.1 increases expression ISO Colforsin results in increased expression of TOB1 mRNA CTD PMID:15313392 NCBI chr10:81,913,689...81,915,727
Ensembl chr10:81,913,689...81,915,716 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO Colforsin results in increased expression of TP53 protein CTD PMID:10642304 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP
ISO		 Colforsin promotes the reaction [Capsaicin results in increased activity of TRPV1]
Colforsin promotes the reaction [Capsaicin results in increased activity of TRPV1 protein]; Colforsin promotes the reaction [Capsaicin results in increased activity of TRPV1]		 CTD PMID:12886029 PMID:17913835 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679 		JBrowse link
G Txnip thioredoxin interacting protein increases activity EXP Colforsin results in increased activity of TXNIP mRNA CTD PMID:21832250 NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974 		JBrowse link
G Tyr tyrosinase increases activity
decreases expression
increases expression
multiple interactions		 ISO Colforsin results in increased activity of TYR protein
Colforsin results in decreased expression of TYR protein
Colforsin results in increased expression of TYR protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Colforsin results in increased expression of TYR protein]; [Colforsin co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] results in decreased expression of TYR protein; [Colforsin co-treated with Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased expression of TYR protein; [Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] promotes the reaction [Colforsin results in increased expression of TYR protein]
Colforsin results in increased expression of TYR mRNA
[resveratrol co-treated with Colforsin] results in decreased activity of TYR protein; [Zinc analog co-treated with Copper analog] inhibits the reaction [Colforsin results in increased expression of TYR mRNA]; Colforsin results in increased expression of and results in increased activity of TYR protein; Particulate Matter inhibits the reaction [Colforsin results in increased expression of TYR mRNA]		 CTD PMID:17460731 PMID:23700242 PMID:28601556 PMID:28849034 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802 		JBrowse link
G Tyrp1 tyrosinase-related protein 1 increases expression
multiple interactions		 ISO Colforsin results in increased expression of TYRP1 mRNA; Colforsin results in increased expression of TYRP1 protein
[Zinc analog co-treated with Copper analog] inhibits the reaction [Colforsin results in increased expression of TYRP1 mRNA]; Particulate Matter inhibits the reaction [Colforsin results in increased expression of TYRP1 mRNA]		 CTD PMID:17460731 PMID:23700242 PMID:28601556 NCBI chr 5:98,387,291...98,406,083
Ensembl chr 5:98,387,291...98,406,083 		JBrowse link
G Ube2j1 ubiquitin-conjugating enzyme E2, J1 increases expression ISO Colforsin results in increased expression of UBE2J1 mRNA CTD PMID:16751804 NCBI chr 5:48,274,387...48,292,699
Ensembl chr 5:48,274,477...48,290,658 		JBrowse link
G Usf1 upstream transcription factor 1 multiple interactions ISO USF1 gene polymorphism promotes the reaction [Colforsin results in increased metabolism of Lipids]; USF1 protein affects the reaction [Colforsin results in increased metabolism of Lipids] CTD PMID:15985485 NCBI chr13:89,797,750...89,805,561
Ensembl chr13:89,797,800...89,805,558 		JBrowse link
G Vasp vasodilator-stimulated phosphoprotein increases phosphorylation ISO Colforsin results in increased phosphorylation of VASP protein CTD PMID:18182247 NCBI chr 1:80,170,608...80,185,882
Ensembl chr 1:80,170,619...80,185,882 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression		 ISO Colforsin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of VEGFA mRNA] CTD PMID:10788502 PMID:19063610 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
G Vim vimentin multiple interactions ISO VIM affects the reaction [[monobutyl phthalate co-treated with Colforsin] results in increased secretion of Progesterone] CTD PMID:26745512 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212 		JBrowse link
G Wt1 WT1 transcription factor increases expression ISO Colforsin results in increased expression of WT1 mRNA CTD PMID:15961562 NCBI chr 3:95,133,221...95,180,574
Ensembl chr 3:95,133,713...95,180,564 		JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of XIAP protein] which results in decreased susceptibility to Cisplatin; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of XIAP mRNA; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of XIAP protein CTD PMID:21255191 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000 		JBrowse link
G Zbtb10 zinc finger and BTB domain containing 10 decreases expression ISO Colforsin results in decreased expression of ZBTB10 mRNA CTD PMID:16751804 NCBI chr 2:94,692,939...94,730,976
Ensembl chr 2:94,692,939...94,730,978 		JBrowse link
G Zfp36l1 zinc finger protein 36, C3H type-like 1 increases expression EXP Colforsin results in increased expression of ZFP36L1 mRNA CTD PMID:23423171 NCBI chr 6:103,308,032...103,313,074
Ensembl chr 6:103,308,045...103,313,074 		JBrowse link
G Zfp36l2 zinc finger protein 36, C3H type-like 2 decreases expression ISO Colforsin results in decreased expression of ZFP36L2 mRNA CTD PMID:15967414 NCBI chr 6:7,417,416...7,423,447
Ensembl chr 6:7,417,425...7,421,456 		JBrowse link
donepezil hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity
affects binding
multiple interactions
affects activity		 ISO
EXP		 Donepezil results in decreased activity of ACHE protein
Donepezil binds to ACHE protein
Donepezil inhibits the reaction [Celecoxib results in increased activity of ACHE protein]; Donepezil inhibits the reaction [Streptozocin results in increased activity of ACHE protein]
ALB protein affects the reaction [Donepezil results in decreased activity of ACHE protein]; Donepezil binds to and results in decreased activity of ACHE protein; Donepezil inhibits the reaction [asoxime chloride inhibits the reaction [Sarin results in decreased activity of ACHE protein]]; Donepezil inhibits the reaction [Obidoxime Chloride metabolite results in decreased activity of ACHE protein]; Donepezil promotes the reaction [Obidoxime Chloride inhibits the reaction [Sarin results in decreased activity of ACHE protein]]
Donepezil affects the activity of ACHE protein
AFDX 384 affects the reaction [Donepezil affects the activity of ACHE protein]; Donepezil inhibits the reaction [Streptozocin results in increased activity of ACHE protein]		 CTD PMID:9228650 PMID:12111444 PMID:12589378 PMID:14535624 PMID:15135892 PMID:18061284 PMID:18208924 PMID:18343489 PMID:18571635 PMID:19345205 PMID:19705549 PMID:23060470 PMID:25522658 PMID:26902639 PMID:27238725 PMID:30481507 PMID:31176713 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G Alb albumin multiple interactions ISO ALB protein affects the reaction [Donepezil results in decreased activity of ACHE protein] CTD PMID:26902639 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G App amyloid beta precursor protein increases abundance
decreases response to substance
multiple interactions		 ISO
EXP		 Donepezil results in increased abundance of APP protein
Donepezil results in decreased susceptibility to APP protein
Donepezil inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of APP protein alternative form]; Donepezil inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of APP protein]; Donepezil inhibits the reaction [APP protein modified form results in increased expression of TNF protein]
Donepezil inhibits the reaction [APP protein modified form affects the localization of RELA protein]; Donepezil inhibits the reaction [APP protein modified form results in increased expression of NOS2 protein]; Donepezil inhibits the reaction [APP protein modified form results in increased expression of PTGS2 protein]; Donepezil inhibits the reaction [APP protein modified form results in increased expression of TNF protein]; Donepezil inhibits the reaction [Streptozocin results in increased expression of APP protein]		 CTD PMID:18061284 PMID:18571635 PMID:24189446 PMID:28734741 PMID:30481507 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Arg1 arginase 1 multiple interactions ISO Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of ARG1 mRNA]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of ARG1 protein]] CTD PMID:26114860 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863 		JBrowse link
G Bace1 beta-secretase 1 multiple interactions ISO Donepezil inhibits the reaction [Streptozocin results in increased expression of BACE1 protein] CTD PMID:30481507 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361 		JBrowse link
G Bche butyrylcholinesterase decreases activity ISO
EXP		 Donepezil results in decreased activity of BCHE protein CTD PMID:16036213 PMID:18656440 PMID:19345205 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Donepezil inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein] CTD PMID:19345205 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 ISO
EXP		 Donepezil results in increased activity of CASP3 protein
Donepezil inhibits the reaction [Hydrogen Peroxide results in decreased expression of CASP3 protein]		 CTD PMID:19345205 PMID:20522977 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp8 caspase 8 increases activity ISO Donepezil results in increased activity of CASP8 protein CTD PMID:20522977 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 increases activity ISO Donepezil results in increased activity of CASP9 protein CTD PMID:20522977 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Cat catalase multiple interactions ISO Donepezil inhibits the reaction [Streptozocin results in decreased activity of CAT protein] CTD PMID:30481507 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Egr1 early growth response 1 multiple interactions
affects expression		 ISO Donepezil inhibits the reaction [Scopolamine results in decreased expression of EGR1 protein]
EGR1 protein affects the reaction [Donepezil affects the expression of ICAM1 protein]
Donepezil affects the expression of EGR1 mRNA; Donepezil affects the expression of EGR1 protein		 CTD PMID:29133030 PMID:32174113 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429 		JBrowse link
G F3 coagulation factor III, tissue factor affects expression ISO Donepezil affects the expression of F3 mRNA; Donepezil affects the expression of F3 protein CTD PMID:32174113 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272 		JBrowse link
G Fiz1 FLT3-interacting zinc finger 1 multiple interactions ISO Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of FIZ1 mRNA]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of FIZ1 protein]] CTD PMID:26114860 NCBI chr 1:72,379,705...72,387,301
Ensembl chr 1:72,380,711...72,387,301 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Donepezil inhibits the reaction [Scopolamine results in decreased expression of FOS protein] CTD PMID:29133030 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
affects expression		 ISO EGR1 protein affects the reaction [Donepezil affects the expression of ICAM1 protein]
Donepezil affects the expression of ICAM1 mRNA; Donepezil affects the expression of ICAM1 protein		 CTD PMID:32174113 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of IL10]] CTD PMID:26114860 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il13 interleukin 13 multiple interactions ISO Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of IL13]] CTD PMID:26114860 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL1B mRNA]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL1B protein]; Donepezil inhibits the reaction [Streptozocin results in increased expression of IL1B protein]; Donepezil inhibits the reaction [Valproic Acid results in increased expression of IL1B protein] CTD PMID:26114860 PMID:30481507 PMID:31369746 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of ARG1 mRNA]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of ARG1 protein]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of CHIL3 mRNA]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of CHIL3 protein]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of FIZ1 mRNA]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of FIZ1 protein]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of IL10]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of IL13]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of TGFB2]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased phosphorylation of STAT6 protein]] CTD PMID:26114860 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531 		JBrowse link
G Il6 interleukin 6 multiple interactions
affects expression
affects secretion		 ISO Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 mRNA]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 protein]; Donepezil inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; Donepezil inhibits the reaction [Valproic Acid results in increased expression of IL6 protein]
Donepezil affects the expression of IL6 mRNA
Donepezil affects the secretion of IL6 protein		 CTD PMID:26114860 PMID:30481507 PMID:31369746 PMID:32174113 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Donepezil inhibits the reaction [Scopolamine results in decreased expression of JUN protein] CTD PMID:29133030 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Donepezil inhibits the reaction [Streptozocin results in decreased phosphorylation of MAPK1 protein] CTD PMID:23562514 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Donepezil inhibits the reaction [Streptozocin results in decreased phosphorylation of MAPK3 protein] CTD PMID:23562514 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP Donepezil inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of MAPK8 protein] CTD PMID:19345205 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP Donepezil inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of MAPK9 protein] CTD PMID:19345205 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions		 ISO Donepezil results in decreased expression of MMP9 protein
Donepezil results in decreased expression of and results in decreased activity of MMP9 protein		 CTD PMID:21750701 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Donepezil inhibits the reaction [Streptozocin results in increased activity of MPO protein] CTD PMID:23060470 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Donepezil inhibits the reaction [APP protein modified form results in increased expression of NOS2 protein]; Donepezil inhibits the reaction [Valproic Acid results in increased expression of NOS2 protein] CTD PMID:24189446 PMID:31369746 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nppb natriuretic peptide B decreases expression ISO Donepezil results in decreased expression of NPPB protein CTD PMID:19879468 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531 		JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 affects expression ISO Donepezil affects the expression of OLR1 mRNA; Donepezil affects the expression of OLR1 protein CTD PMID:32174113 NCBI chr 4:163,239,853...163,261,937
Ensembl chr 4:163,239,849...163,261,958 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression
multiple interactions
affects expression		 ISO Donepezil results in decreased expression of PTGS1 mRNA
[Rivastigmine co-treated with Donepezil] results in decreased expression of PTGS1 mRNA; [Rivastigmine co-treated with Donepezil] results in decreased expression of PTGS1 protein; [Sodium Fluoride co-treated with Donepezil] results in increased expression of PTGS1 mRNA; [Sodium Fluoride co-treated with Donepezil] results in increased expression of PTGS1 protein; [Sodium Fluoride co-treated with Rivastigmine co-treated with Donepezil] results in increased expression of PTGS1 mRNA; [Sodium Fluoride co-treated with Rivastigmine co-treated with Donepezil] results in increased expression of PTGS1 protein
Donepezil affects the expression of PTGS1 protein		 CTD PMID:29777723 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression		 ISO [Donepezil co-treated with Rivastigmine] results in decreased expression of PTGS2 protein; [Rivastigmine co-treated with Donepezil] results in decreased expression of PTGS2 mRNA
Donepezil inhibits the reaction [APP protein modified form results in increased expression of PTGS2 protein]; Donepezil inhibits the reaction [Valproic Acid results in increased expression of PTGS2 protein]
Donepezil results in decreased expression of PTGS2 mRNA; Donepezil results in decreased expression of PTGS2 protein		 CTD PMID:24189446 PMID:29777723 PMID:31369746 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Donepezil inhibits the reaction [APP protein modified form affects the localization of RELA protein]; Donepezil inhibits the reaction [Valproic Acid results in increased expression of RELA protein] CTD PMID:24189446 PMID:31369746 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Donepezil inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP Donepezil inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD1 mRNA] CTD PMID:28734741 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions EXP Donepezil inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD3 mRNA] CTD PMID:28734741 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions ISO Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased phosphorylation of STAT6 protein]] CTD PMID:26114860 NCBI chr 7:70,946,228...70,963,542
Ensembl chr 7:70,946,228...70,964,484 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions ISO Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of TGFB2]] CTD PMID:26114860 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
affects expression
affects secretion		 ISO
EXP		 Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF mRNA]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF protein]; Donepezil inhibits the reaction [APP protein modified form results in increased expression of TNF protein]; Donepezil inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Donepezil inhibits the reaction [Valproic Acid results in increased expression of TNF protein]
Donepezil affects the expression of TNF mRNA
Donepezil affects the secretion of TNF protein		 CTD PMID:24189446 PMID:26114860 PMID:30481507 PMID:31369746 PMID:32174113 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Donepezil inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 protein] CTD PMID:19345205 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions EXP Donepezil inhibits the reaction [Hydrogen Peroxide results in decreased expression of XIAP protein] CTD PMID:19345205 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000 		JBrowse link
dorzolamide hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ca3 carbonic anhydrase 3 multiple interactions ISO dorzolamide binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410 		JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO dorzolamide binds to and results in decreased activity of CA2 protein CTD PMID:17826101 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029 		JBrowse link
erlotinib hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Erlotinib Hydrochloride inhibits the reaction [ABCG2 gene mutant form results in decreased susceptibility to Mitoxantrone]; Erlotinib Hydrochloride inhibits the reaction [ABCG2 protein results in decreased susceptibility to Mitoxantrone]; Erlotinib Hydrochloride inhibits the reaction [ABCG2 protein results in increased export of Methotrexate]; Erlotinib Hydrochloride inhibits the reaction [ABCG2 results in increased export of Methotrexate] CTD PMID:18829547 PMID:19232821 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases phosphorylation ISO Erlotinib Hydrochloride results in increased phosphorylation of ACACA protein CTD PMID:23707608 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910 		JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 multiple interactions ISO [Interleukin 1 Receptor Antagonist Protein co-treated with Erlotinib Hydrochloride] results in decreased expression of ADGRE1 protein CTD PMID:27738319 NCBI chr 9:9,431,888...9,585,883
Ensembl chr 9:9,431,860...9,585,865 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions		 ISO Erlotinib Hydrochloride results in decreased phosphorylation of AKT1 protein
Erlotinib Hydrochloride inhibits the reaction [Derp2 allergen, Dermatophagoides pteronyssinus results in increased phosphorylation of AKT1 protein]		 CTD PMID:21195724 PMID:30623574 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions ISO [Erlotinib Hydrochloride co-treated with Arsenic Trioxide] results in increased expression of APAF1 mRNA CTD PMID:29274334 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192 		JBrowse link
G Areg amphiregulin affects response to substance ISO AREG protein affects the susceptibility to Erlotinib Hydrochloride CTD PMID:18980991 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179 		JBrowse link
G Arf1 ADP-ribosylation factor 1 decreases response to substance ISO ARF1 mRNA results in decreased susceptibility to Erlotinib Hydrochloride CTD PMID:23125191 NCBI chr10:45,562,700...45,579,214
Ensembl chr10:45,563,547...45,579,029 		JBrowse link
G Atf4 activating transcription factor 4 increases expression EXP Erlotinib Hydrochloride results in increased expression of ATF4 protein CTD PMID:24768708 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772 		JBrowse link
G Atg5 autophagy related 5 decreases response to substance
increases expression		 ISO ATG5 protein results in decreased susceptibility to Erlotinib Hydrochloride
Erlotinib Hydrochloride results in increased expression of ATG5 protein		 CTD PMID:21655094 PMID:23917044 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140 		JBrowse link
G Atg7 autophagy related 7 increases expression ISO Erlotinib Hydrochloride results in increased expression of ATG7 protein CTD PMID:21655094 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124 		JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO Erlotinib Hydrochloride promotes the reaction [Arsenic Trioxide results in increased expression of ATM mRNA] CTD PMID:29274334 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045 		JBrowse link
G Atr ATR serine/threonine kinase multiple interactions
increases expression		 ISO Erlotinib Hydrochloride promotes the reaction [Arsenic Trioxide results in increased expression of ATR mRNA]
Erlotinib Hydrochloride results in increased expression of ATR mRNA		 CTD PMID:29274334 NCBI chr 8:103,673,578...103,770,886
Ensembl chr 8:103,673,411...103,770,947 		JBrowse link
G Axl Axl receptor tyrosine kinase decreases response to substance
multiple interactions		 ISO AXL results in decreased susceptibility to Erlotinib Hydrochloride
[GSK 1363089 results in decreased activity of AXL protein] which results in increased susceptibility to Erlotinib Hydrochloride; [MP470 results in decreased activity of AXL protein] which results in increased susceptibility to Erlotinib Hydrochloride		 CTD PMID:22751098 NCBI chr 1:82,550,892...82,580,761
Ensembl chr 1:82,549,420...82,580,761 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO Erlotinib Hydrochloride promotes the reaction [Arsenic Trioxide results in increased expression of BAD mRNA] CTD PMID:29274334 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Erlotinib Hydrochloride promotes the reaction [Arsenic Trioxide results in increased expression of BAX mRNA] CTD PMID:29274334 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions
increases expression		 ISO [Erlotinib Hydrochloride co-treated with Arsenic Trioxide] results in increased expression of BBC3 mRNA; Erlotinib Hydrochloride promotes the reaction [Resveratrol results in increased expression of BBC3 protein]; Resveratrol promotes the reaction [Erlotinib Hydrochloride results in increased expression of BBC3 protein] CTD PMID:25895606 PMID:29274334 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions		 ISO Erlotinib Hydrochloride results in increased expression of BCL2 mRNA; Erlotinib Hydrochloride results in increased expression of BCL2 protein
[Erlotinib Hydrochloride co-treated with Arsenic Trioxide] results in decreased expression of BCL2 mRNA; [Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2 protein]] which results in increased susceptibility to Erlotinib Hydrochloride; Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2 protein]		 CTD PMID:23894143 PMID:29274334 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions
increases expression		 ISO Harmine promotes the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L11 protein] CTD PMID:30171258 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192 		JBrowse link
G Bcl2l2 Bcl2-like 2 increases expression
multiple interactions		 ISO Erlotinib Hydrochloride results in increased expression of BCL2L2 mRNA; Erlotinib Hydrochloride results in increased expression of BCL2L2 protein
[Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L2 protein]] which results in increased susceptibility to Erlotinib Hydrochloride; Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L2 protein]		 CTD PMID:23894143 NCBI chr15:33,543,774...33,549,165
Ensembl chr15:33,544,312...33,549,164 		JBrowse link
G Becn1 beclin 1 decreases response to substance ISO BECN1 protein results in decreased susceptibility to Erlotinib Hydrochloride CTD PMID:23917044 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression		 ISO [Erlotinib Hydrochloride co-treated with Arsenic Trioxide] results in decreased expression of BIRC5 mRNA; Erlotinib Hydrochloride inhibits the reaction [betulinic acid results in decreased expression of BIRC5 protein]; Erlotinib Hydrochloride promotes the reaction [Resveratrol results in decreased expression of BIRC5 protein]; Resveratrol promotes the reaction [Erlotinib Hydrochloride results in decreased expression of BIRC5 protein] CTD PMID:25895606 PMID:29274334 PMID:30136359 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413 		JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions ISO Erlotinib Hydrochloride inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 protein] CTD PMID:25981168 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282 		JBrowse link
G Brca1 BRCA1, DNA repair associated multiple interactions ISO [Erlotinib Hydrochloride results in decreased activity of EGFR protein] which results in decreased phosphorylation of BRCA1 protein CTD PMID:23548265 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681 		JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
increases activity		 ISO Erlotinib Hydrochloride results in increased cleavage of CASP3 protein
[TWIST1 protein results in decreased susceptibility to Erlotinib Hydrochloride] which results in decreased cleavage of CASP3 protein
Erlotinib Hydrochloride results in increased activity of CASP3 protein
Erlotinib Hydrochloride promotes the reaction [resveratrol results in increased activity of CASP3 protein]; resveratrol promotes the reaction [Erlotinib Hydrochloride results in increased activity of CASP3 protein]		 CTD PMID:23125191 PMID:25895606 PMID:30171258 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in decreased expression of CCL2 mRNA; [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in increased expression of CCL2 mRNA CTD PMID:27738319 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO [Erlotinib Hydrochloride co-treated with Arsenic Trioxide] results in decreased expression of CCNB1 mRNA CTD PMID:29274334 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Erlotinib Hydrochloride inhibits the reaction [sodium arsenite results in increased expression of CCND1 protein] CTD PMID:19168569 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Cd69 Cd69 molecule decreases expression ISO Erlotinib Hydrochloride results in decreased expression of CD69 protein CTD PMID:21195724 NCBI chr 4:163,041,147...163,049,065
Ensembl chr 4:163,041,141...163,049,084 		JBrowse link
G Cdh1 cadherin 1 multiple interactions
decreases expression		 ISO
EXP		 Erlotinib Hydrochloride promotes the reaction [Deoxycholic Acid results in decreased glycosylation of and results in increased degradation of CDH1 protein]; Erlotinib Hydrochloride results in decreased glycosylation of and results in increased degradation of CDH1 protein
Erlotinib Hydrochloride results in decreased expression of CDH1 mRNA; Erlotinib Hydrochloride results in decreased expression of CDH1 protein
DDIT3 mutant form inhibits the reaction [Erlotinib Hydrochloride results in decreased expression of CDH1 protein]		 CTD PMID:22223758 PMID:24768708 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases phosphorylation ISO Erlotinib Hydrochloride results in decreased phosphorylation of CDK4 protein CTD PMID:21195724 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions
decreases expression		 ISO betulinic acid promotes the reaction [Erlotinib Hydrochloride results in decreased expression of CDK6 protein] CTD PMID:30136359 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions		 ISO Erlotinib Hydrochloride results in increased expression of CDKN1A mRNA
Erlotinib Hydrochloride promotes the reaction [Arsenic Trioxide results in increased expression of CDKN1A mRNA]		 CTD PMID:29274334 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Chfr checkpoint with forkhead and ring finger domains multiple interactions ISO CHFR protein affects the susceptibility to [Cisplatin co-treated with Erlotinib Hydrochloride] CTD PMID:20705357 NCBI chr12:52,562,594...52,596,162
Ensembl chr12:52,562,597...52,596,076 		JBrowse link
G Chrdl2 chordin-like 2 multiple interactions ISO [gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of CHRDL2 protein CTD PMID:24979617 NCBI chr 1:165,008,997...165,036,431
Ensembl chr 1:165,008,912...165,036,435 		JBrowse link
G Csf3 colony stimulating factor 3 increases secretion ISO Erlotinib Hydrochloride results in increased secretion of CSF3 protein CTD PMID:27738319 NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression		 ISO [betulinic acid co-treated with Erlotinib Hydrochloride] results in decreased expression of CTNNB1 protein
Erlotinib Hydrochloride results in decreased expression of CTNNB1 protein		 CTD PMID:30136359 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 multiple interactions ISO [gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of CXCL11 protein CTD PMID:24979617 NCBI chr14:17,195,395...17,198,170
Ensembl chr14:17,195,014...17,198,291 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO Erlotinib Hydrochloride results in decreased activity of CYP19A1 protein CTD PMID:26141389 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Erlotinib Hydrochloride results in increased expression of CYP2B6 mRNA CTD PMID:30364229 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases expression
decreases activity		 ISO Erlotinib Hydrochloride results in increased expression of CYP3A4 mRNA
Erlotinib Hydrochloride results in decreased activity of CYP3A4 protein		 CTD PMID:18839173 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Cyp51 cytochrome P450, family 51 increases response to substance ISO CYP51A1 mRNA results in increased susceptibility to Erlotinib Hydrochloride CTD PMID:23125191 NCBI chr 4:27,175,564...27,194,018
Ensembl chr 4:27,175,243...27,194,018 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions		 ISO
EXP		 Erlotinib Hydrochloride results in increased expression of DDIT3 protein
DDIT3 mutant form inhibits the reaction [Erlotinib Hydrochloride results in decreased expression of CDH1 protein]; DDIT3 mutant form inhibits the reaction [Erlotinib Hydrochloride results in increased expression of IL6 mRNA]; DDIT3 mutant form inhibits the reaction [Erlotinib Hydrochloride results in increased secretion of IL6 protein]		 CTD PMID:24768708 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Dennd6b DENN domain containing 6B decreases expression ISO Erlotinib Hydrochloride results in decreased expression of DENND6B mRNA CTD PMID:27720938 NCBI chr 7:130,162,728...130,178,282
Ensembl chr 7:130,164,675...130,176,696 		JBrowse link
G Dusp1 dual specificity phosphatase 1 multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in increased expression of DUSP1 mRNA CTD PMID:27738319 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO
EXP		 Erlotinib Hydrochloride inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Cisplatin]]; Erlotinib Hydrochloride inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]; Erlotinib Hydrochloride inhibits the reaction [EGF protein results in decreased susceptibility to Crizotinib]; Erlotinib Hydrochloride inhibits the reaction [EGF protein results in increased activity of ELK1 protein]; Erlotinib Hydrochloride inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Erlotinib Hydrochloride inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein]; Erlotinib Hydrochloride promotes the reaction [EGF protein binds to EGFR protein]
Erlotinib Hydrochloride inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Erlotinib Hydrochloride inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]		 CTD PMID:21613822 PMID:21787763 PMID:22553343 PMID:25625231 PMID:27427493 PMID:30364229 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor affects response to substance
decreases expression
decreases phosphorylation
decreases activity
multiple interactions
decreases response to substance		 ISO EGFR protein affects the susceptibility to Erlotinib Hydrochloride; EGFR protein mutant form affects the susceptibility to Erlotinib Hydrochloride
Erlotinib Hydrochloride results in decreased expression of EGFR protein modified form
Erlotinib Hydrochloride results in decreased phosphorylation of EGFR protein
Erlotinib Hydrochloride results in decreased activity of EGFR protein
[Erlotinib Hydrochloride results in decreased activity of EGFR protein] which results in decreased expression of RAD50 protein; [Erlotinib Hydrochloride results in decreased activity of EGFR protein] which results in decreased expression of RAD51 protein; [Erlotinib Hydrochloride results in decreased activity of EGFR protein] which results in decreased phosphorylation of BRCA1 protein; EGFR gene mutant form results in increased susceptibility to [gemcitabine co-treated with Cisplatin co-treated with Erlotinib Hydrochloride]; Erlotinib Hydrochloride inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of EGFR protein]; Erlotinib Hydrochloride inhibits the reaction [Derp2 allergen, Dermatophagoides pteronyssinus results in increased phosphorylation of EGFR protein]; Erlotinib Hydrochloride inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Erlotinib Hydrochloride inhibits the reaction [EGFR protein mutant form results in increased expression of FOXG1 mRNA]; Erlotinib Hydrochloride inhibits the reaction [EGFR protein mutant form results in increased expression of FOXG1 protein]; Erlotinib Hydrochloride inhibits the reaction [EGFR protein mutant form results in increased expression of SOX9 mRNA]; Erlotinib Hydrochloride inhibits the reaction [EGFR protein mutant form results in increased expression of SOX9 protein]; Erlotinib Hydrochloride inhibits the reaction [Particulate Matter analog results in increased phosphorylation of EGFR protein]; Erlotinib Hydrochloride inhibits the reaction [sodium arsenite results in increased phosphorylation of EGFR protein]; Erlotinib Hydrochloride promotes the reaction [Deoxycholic Acid results in decreased glycosylation of and results in decreased expression of EGFR protein]; Erlotinib Hydrochloride promotes the reaction [EGF protein binds to EGFR protein]; Erlotinib Hydrochloride results in decreased activity of and results in decreased phosphorylation of EGFR protein; Erlotinib Hydrochloride results in decreased glycosylation of and results in decreased expression of EGFR protein
EGFR protein mutant form results in decreased susceptibility to Erlotinib Hydrochloride		 CTD PMID:12907618 PMID:16407879 PMID:16891461 PMID:19168569 PMID:21080748 PMID:21541241 PMID:21787763 PMID:22223758 PMID:22751098 PMID:23099361 PMID:23440206 PMID:23548265 PMID:23894143 PMID:25625231 PMID:26455392 PMID:28101945 PMID:30136359 PMID:30364229 PMID:30623574 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases expression EXP Erlotinib Hydrochloride results in increased expression of EIF2S1 protein modified form CTD PMID:24768708 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041 		JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions ISO Erlotinib Hydrochloride inhibits the reaction [EGF protein results in increased activity of ELK1 protein]; Erlotinib Hydrochloride inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein] CTD PMID:25625231 PMID:30364229 NCBI chr  X:1,287,875...1,304,822
Ensembl chr  X:1,297,099...1,304,822 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 decreases response to substance ISO ERBB3 mRNA results in decreased susceptibility to Erlotinib Hydrochloride CTD PMID:23125191 NCBI chr 7:2,989,202...3,010,610
Ensembl chr 7:2,989,340...3,010,350 		JBrowse link
G Foxg1 forkhead box G1 multiple interactions
decreases expression		 ISO Erlotinib Hydrochloride inhibits the reaction [EGFR protein mutant form results in increased expression of FOXG1 mRNA]; Erlotinib Hydrochloride inhibits the reaction [EGFR protein mutant form results in increased expression of FOXG1 protein]
Erlotinib Hydrochloride results in decreased expression of FOXG1 protein		 CTD PMID:26455392 NCBI chr 6:69,971,227...69,974,037
Ensembl chr 6:69,971,227...69,974,037 		JBrowse link
G Foxo3 forkhead box O3 decreases phosphorylation ISO Erlotinib Hydrochloride results in decreased phosphorylation of FOXO3 protein CTD PMID:23099361 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144 		JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions ISO [gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of GDF15 protein CTD PMID:24979617 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978 		JBrowse link
G Gmpr guanosine monophosphate reductase decreases expression ISO Erlotinib Hydrochloride results in decreased expression of GMPR mRNA CTD PMID:27720938 NCBI chr17:19,543,274...19,580,929
Ensembl chr17:19,543,275...19,580,929 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression ISO Erlotinib Hydrochloride results in decreased expression of GSK3B protein modified form CTD PMID:30136359 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268 		JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases expression		 ISO Erlotinib Hydrochloride promotes the reaction [Resveratrol results in increased expression of H2AX protein modified form]; Resveratrol promotes the reaction [Erlotinib Hydrochloride results in increased expression of H2AX protein modified form] CTD PMID:25895606 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981 		JBrowse link
G Hbegf heparin-binding EGF-like growth factor multiple interactions ISO Erlotinib Hydrochloride inhibits the reaction [HBEGF protein results in decreased susceptibility to crizotinib] CTD PMID:22553343 NCBI chr18:29,330,302...29,340,185
Ensembl chr18:29,329,764...29,340,403 		JBrowse link
G Ifitm3 interferon induced transmembrane protein 3 decreases expression ISO Erlotinib Hydrochloride results in decreased expression of IFITM3 mRNA CTD PMID:27720938 NCBI chr 1:213,810,712...213,811,821
Ensembl chr 1:213,810,696...213,811,901 		JBrowse link
G Ifng interferon gamma decreases secretion ISO Erlotinib Hydrochloride results in decreased secretion of IFNG protein CTD PMID:21195724 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Il17f interleukin 17F increases expression ISO
EXP		 Erlotinib Hydrochloride results in increased expression of IL17F mRNA CTD PMID:24768708 NCBI chr 9:26,885,702...26,897,219
Ensembl chr 9:26,885,708...26,897,219 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in increased expression of IL1A mRNA CTD PMID:27738319 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion		 ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in increased expression of IL1B mRNA
Erlotinib Hydrochloride results in increased secretion of IL1B protein		 CTD PMID:27738319 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in decreased expression of IL1R1 mRNA CTD PMID:27738319 NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670 		JBrowse link
G Il1r2 interleukin 1 receptor type 2 multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which affects the expression of IL1R2 mRNA CTD PMID:27738319 NCBI chr 9:46,840,646...46,881,241
Ensembl chr 9:46,840,992...46,881,264 		JBrowse link
G Il1rap interleukin 1 receptor accessory protein multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in increased expression of IL1RAP mRNA CTD PMID:27738319 NCBI chr11:77,456,648...77,593,208
Ensembl chr11:77,463,954...77,593,207 		JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which affects the expression of IL1RN mRNA; [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in decreased expression of IL1RN mRNA; [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in decreased secretion of IL1RN protein CTD PMID:27738319 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614 		JBrowse link
G Il2 interleukin 2 decreases secretion ISO Erlotinib Hydrochloride results in decreased secretion of IL2 protein CTD PMID:21195724 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854 		JBrowse link
G Il25 interleukin 25 increases expression ISO
EXP		 Erlotinib Hydrochloride results in increased expression of IL25 mRNA CTD PMID:24768708 NCBI chr15:33,594,852...33,599,692
Ensembl chr15:33,596,301...33,599,685 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha decreases expression ISO Erlotinib Hydrochloride results in decreased expression of IL2RA protein CTD PMID:21195724 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071 		JBrowse link
G Il6 interleukin 6 increases expression
increases secretion
multiple interactions		 ISO
EXP		 Erlotinib Hydrochloride results in increased expression of IL6 mRNA
Erlotinib Hydrochloride results in increased secretion of IL6 protein
Erlotinib Hydrochloride inhibits the reaction [Derp2 allergen, Dermatophagoides pteronyssinus results in increased expression of IL6 mRNA]; Erlotinib Hydrochloride inhibits the reaction [Derp2 allergen, Dermatophagoides pteronyssinus results in increased secretion of IL6 protein]; Interleukin 1 Receptor Antagonist Protein inhibits the reaction [Erlotinib Hydrochloride results in increased secretion of IL6 protein]
DDIT3 mutant form inhibits the reaction [Erlotinib Hydrochloride results in increased expression of IL6 mRNA]; DDIT3 mutant form inhibits the reaction [Erlotinib Hydrochloride results in increased secretion of IL6 protein]		 CTD PMID:24768708 PMID:27738319 PMID:30623574 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in decreased expression of IRAK1 mRNA CTD PMID:27738319 NCBI chr  X:156,716,469...156,726,367
Ensembl chr  X:156,716,604...156,725,977 		JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression EXP Erlotinib Hydrochloride results in decreased expression of ITGB1 mRNA CTD PMID:24768708 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535 		JBrowse link
G Jak2 Janus kinase 2 decreases phosphorylation ISO Erlotinib Hydrochloride results in decreased phosphorylation of JAK2 protein CTD PMID:23894143 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects activity ISO Erlotinib Hydrochloride affects the activity of KCNH2 protein CTD PMID:23707608 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253 		JBrowse link
G Kitlg KIT ligand multiple interactions ISO [gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of KITLG protein CTD PMID:24979617 NCBI chr 7:42,269,784...42,351,054
Ensembl chr 7:42,269,784...42,351,054 		JBrowse link
G Kras KRAS proto-oncogene, GTPase increases response to substance ISO KRAS protein results in increased susceptibility to Erlotinib Hydrochloride CTD PMID:20705357 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO Erlotinib Hydrochloride promotes the reaction [betulinic acid results in increased expression of MAP1LC3B protein modified form] CTD PMID:30136359 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions		 ISO
EXP		 Erlotinib Hydrochloride results in decreased phosphorylation of MAPK1 protein
Erlotinib Hydrochloride inhibits the reaction [Particulate Matter analog results in increased phosphorylation of MAPK1 protein]
Erlotinib Hydrochloride inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]
Erlotinib Hydrochloride inhibits the reaction [Alprenolol results in increased phosphorylation of MAPK1 protein]; Erlotinib Hydrochloride inhibits the reaction [carvedilol results in increased phosphorylation of MAPK1 protein]		 CTD PMID:18787115 PMID:18980991 PMID:21195724 PMID:27427493 PMID:28101945 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions		 ISO
EXP		 Erlotinib Hydrochloride results in decreased phosphorylation of MAPK3 protein
Erlotinib Hydrochloride inhibits the reaction [Particulate Matter analog results in increased phosphorylation of MAPK3 protein]
Erlotinib Hydrochloride inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]
Erlotinib Hydrochloride inhibits the reaction [Alprenolol results in increased phosphorylation of MAPK3 protein]; Erlotinib Hydrochloride inhibits the reaction [carvedilol results in increased phosphorylation of MAPK3 protein]		 CTD PMID:18787115 PMID:18980991 PMID:21195724 PMID:27427493 PMID:28101945 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression
multiple interactions		 ISO Erlotinib Hydrochloride results in decreased expression of MCL1 protein
resveratrol promotes the reaction [Erlotinib Hydrochloride results in decreased expression of MCL1 protein]		 CTD PMID:25895606 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase multiple interactions
decreases phosphorylation		 ISO [Erlotinib Hydrochloride co-treated with Dasatinib] results in decreased phosphorylation of MET protein
Erlotinib Hydrochloride results in decreased phosphorylation of MET protein		 CTD PMID:21106725 PMID:23894143 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665 		JBrowse link
G Micb MHC class I polypeptide-related sequence B increases expression ISO Erlotinib Hydrochloride results in increased expression of MICB protein CTD PMID:21951556 NCBI chr 1:79,754,587...79,772,092
Ensembl chr 1:79,754,587...79,772,092 		JBrowse link
G Mmp14 matrix metallopeptidase 14 multiple interactions ISO Erlotinib Hydrochloride inhibits the reaction [Acrolein results in increased expression of MMP14 mRNA] CTD PMID:19661247 NCBI chr15:33,074,441...33,083,666
Ensembl chr15:33,074,441...33,083,655 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO [Erlotinib Hydrochloride co-treated with Arsenic Trioxide] results in decreased expression of MMP2 mRNA CTD PMID:29274334 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [Erlotinib Hydrochloride co-treated with Arsenic Trioxide] results in decreased expression of MMP9 mRNA CTD PMID:29274334 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 decreases response to substance
multiple interactions		 ISO MSMO1 protein results in decreased susceptibility to Erlotinib Hydrochloride
MSMO1 protein inhibits the reaction [Erlotinib Hydrochloride results in decreased expression of RPS6 protein modified form]		 CTD PMID:23125191 NCBI chr16:26,859,441...26,875,880
Ensembl chr16:26,859,397...26,875,973 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation
multiple interactions		 ISO Erlotinib Hydrochloride results in decreased phosphorylation of MTOR protein
resveratrol promotes the reaction [Erlotinib Hydrochloride results in decreased phosphorylation of MTOR protein]		 CTD PMID:21655094 PMID:25895606 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO Erlotinib Hydrochloride inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA] CTD PMID:18006877 PMID:19661247 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which affects the expression of MYD88 mRNA CTD PMID:27738319 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which affects the expression of NFKBIA mRNA CTD PMID:27738319 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Nol10 nucleolar protein 10 decreases expression ISO Erlotinib Hydrochloride results in decreased expression of NOL10 mRNA CTD PMID:27720938 NCBI chr 6:42,656,661...42,745,099
Ensembl chr 6:42,656,616...42,745,098 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions
decreases response to substance
increases expression		 ISO Erlotinib Hydrochloride results in increased expression of and results in increased stability of NOX4 mRNA
NOX4 protein results in decreased susceptibility to Erlotinib Hydrochloride
Erlotinib Hydrochloride results in increased expression of NOX4 protein		 CTD PMID:23917044 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Erlotinib Hydrochloride binds to and results in increased activity of NR1I2 protein CTD PMID:18839173 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects localization ISO Erlotinib Hydrochloride affects the localization of NR1I3 protein mutant form CTD PMID:30364229 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277 		JBrowse link
G Nsdhl NAD(P) dependent steroid dehydrogenase-like decreases response to substance ISO NSDHL protein results in decreased susceptibility to Erlotinib Hydrochloride CTD PMID:23125191 NCBI chr  X:152,933,118...152,964,399
Ensembl chr  X:152,933,069...152,964,390 		JBrowse link
G Osm oncostatin M multiple interactions ISO [gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of OSM protein CTD PMID:24979617 NCBI chr14:84,457,487...84,469,426
Ensembl chr14:84,465,515...84,470,409 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
increases expression		 ISO Erlotinib Hydrochloride results in increased cleavage of PARP1 protein
[TWIST1 protein results in decreased susceptibility to Erlotinib Hydrochloride] which results in decreased cleavage of PARP1 protein; Harmine promotes the reaction [Erlotinib Hydrochloride results in increased cleavage of PARP1 protein]; Resveratrol promotes the reaction [Erlotinib Hydrochloride results in increased expression of PARP1 protein modified form]; TWIST1 protein inhibits the reaction [Erlotinib Hydrochloride results in increased cleavage of PARP1 protein]		 CTD PMID:23125191 PMID:25895606 PMID:30171258 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Pml PML nuclear body scaffold increases expression
decreases response to substance
increases localization		 ISO Erlotinib Hydrochloride results in increased expression of PML protein
PML protein results in decreased susceptibility to Erlotinib Hydrochloride
Erlotinib Hydrochloride results in increased localization of PML protein		 CTD PMID:23440206 NCBI chr 8:63,002,515...63,034,310
Ensembl chr 8:63,004,870...63,034,226 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in increased expression of PTGS2 mRNA CTD PMID:27738319 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Ptpn9 protein tyrosine phosphatase, non-receptor type 9 decreases expression
decreases response to substance		 ISO Erlotinib Hydrochloride results in decreased expression of PTPN9 protein
PTPN9 mutant form results in decreased susceptibility to Erlotinib Hydrochloride		 CTD PMID:23894143 NCBI chr 8:61,658,851...61,739,458
Ensembl chr 8:61,659,445...61,739,434 		JBrowse link
G Rad50 RAD50 double strand break repair protein multiple interactions ISO [Erlotinib Hydrochloride results in decreased activity of EGFR protein] which results in decreased expression of RAD50 protein CTD PMID:23548265 NCBI chr10:39,002,130...39,054,042
Ensembl chr10:39,001,498...39,054,142 		JBrowse link
G Rad51 RAD51 recombinase multiple interactions ISO [Erlotinib Hydrochloride results in decreased activity of EGFR protein] which results in decreased expression of RAD51 protein CTD PMID:23548265 NCBI chr 3:110,918,240...110,942,920
Ensembl chr 3:110,918,243...110,942,917 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases phosphorylation ISO Erlotinib Hydrochloride results in decreased phosphorylation of RAF1 protein CTD PMID:21195724 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation
multiple interactions
decreases expression		 ISO Erlotinib Hydrochloride results in decreased phosphorylation of RB1 protein
betulinic acid promotes the reaction [Erlotinib Hydrochloride results in decreased expression of RB1 protein modified form]; Erlotinib Hydrochloride promotes the reaction [betulinic acid results in decreased expression of RB1 protein modified form]		 CTD PMID:21195724 PMID:30136359 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Erlotinib Hydrochloride inhibits the reaction [Particulate Matter analog results in increased acetylation of RELA protein] CTD PMID:28101945 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation
decreases expression
multiple interactions		 ISO Erlotinib Hydrochloride results in decreased phosphorylation of RPS6 protein
Erlotinib Hydrochloride results in decreased expression of RPS6 protein modified form
MSMO1 protein inhibits the reaction [Erlotinib Hydrochloride results in decreased expression of RPS6 protein modified form]		 CTD PMID:23125191 PMID:23440206 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation
multiple interactions		 ISO Erlotinib Hydrochloride results in decreased phosphorylation of RPS6KB1 protein
resveratrol promotes the reaction [Erlotinib Hydrochloride results in decreased phosphorylation of RPS6KB1 protein]		 CTD PMID:21655094 PMID:25895606 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364 		JBrowse link
G Selenbp1 selenium binding protein 1 decreases expression ISO Erlotinib Hydrochloride results in decreased expression of SELENBP1 mRNA CTD PMID:27720938 NCBI chr 2:196,105,592...196,146,474
Ensembl chr 2:196,105,569...196,113,149 		JBrowse link
G Siah2 siah E3 ubiquitin protein ligase 2 decreases expression ISO Erlotinib Hydrochloride results in decreased expression of SIAH2 mRNA CTD PMID:27720938 NCBI chr 2:148,874,151...148,891,900
Ensembl chr 2:148,874,151...148,891,900 		JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO [Erlotinib Hydrochloride co-treated with Arsenic Trioxide] results in decreased expression of SNAI1 mRNA CTD PMID:29274334 NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378 		JBrowse link
G Snai2 snail family transcriptional repressor 2 multiple interactions ISO [Erlotinib Hydrochloride co-treated with Arsenic Trioxide] results in decreased expression of SNAI2 mRNA CTD PMID:29274334 NCBI chr11:90,404,421...90,406,730
Ensembl chr11:90,403,333...90,406,797 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression EXP Erlotinib Hydrochloride results in increased expression of SOCS3 mRNA CTD PMID:24768708 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040 		JBrowse link
G Sox9 SRY-box transcription factor 9 multiple interactions
decreases expression		 ISO Erlotinib Hydrochloride inhibits the reaction [EGFR protein mutant form results in increased expression of SOX9 mRNA]; Erlotinib Hydrochloride inhibits the reaction [EGFR protein mutant form results in increased expression of SOX9 protein]
Erlotinib Hydrochloride results in decreased expression of SOX9 protein		 CTD PMID:26455392 NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379 		JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO Erlotinib Hydrochloride results in increased expression of SQSTM1 protein CTD PMID:30136359 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase decreases phosphorylation ISO Erlotinib Hydrochloride results in decreased phosphorylation of SRC protein CTD PMID:23894143 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation
decreases expression
increases response to substance
decreases response to substance
multiple interactions		 ISO Erlotinib Hydrochloride results in increased phosphorylation of STAT3 protein
Erlotinib Hydrochloride results in decreased expression of STAT3 protein modified form
STAT3 mutant form results in increased susceptibility to Erlotinib Hydrochloride
STAT3 mRNA results in decreased susceptibility to Erlotinib Hydrochloride
[betulinic acid co-treated with Erlotinib Hydrochloride] results in decreased expression of STAT3 protein modified form; [Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased phosphorylation of STAT3 protein]] which results in increased susceptibility to Erlotinib Hydrochloride; Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased phosphorylation of STAT3 protein]		 CTD PMID:23125191 PMID:23894143 PMID:30136359 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233 		JBrowse link
G Tent5c terminal nucleotidyltransferase 5C decreases expression ISO Erlotinib Hydrochloride results in decreased expression of TENT5C mRNA CTD PMID:27720938 NCBI chr 2:202,797,766...202,816,562
Ensembl chr 2:202,798,198...202,816,562 		JBrowse link
G Tfap2a transcription factor AP-2 alpha multiple interactions ISO Erlotinib Hydrochloride inhibits the reaction [TFAP2A protein binds to ULBP1 promoter]; Tetradecanoylphorbol Acetate inhibits the reaction [Erlotinib Hydrochloride inhibits the reaction [TFAP2A protein binds to ULBP1 promoter]] CTD PMID:21499124 PMID:21951556 NCBI chr17:24,653,342...24,670,457
Ensembl chr17:24,654,902...24,670,457 		JBrowse link
G Tgfa transforming growth factor alpha multiple interactions ISO Erlotinib Hydrochloride inhibits the reaction [TGFA protein results in decreased susceptibility to crizotinib] CTD PMID:22553343 NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Erlotinib Hydrochloride inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Cisplatin]]; Erlotinib Hydrochloride inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]] CTD PMID:21613822 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 decreases response to substance ISO TMED2 mRNA results in decreased susceptibility to Erlotinib Hydrochloride CTD PMID:23125191 NCBI chr12:37,471,259...37,480,344
Ensembl chr12:37,471,260...37,480,297 		JBrowse link
G Tnfsf8 TNF superfamily member 8 multiple interactions ISO [gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of TNFSF8 protein CTD PMID:24979617 NCBI chr 5:79,664,779...79,691,547
Ensembl chr 5:79,664,765...79,691,258 		JBrowse link
G Tollip toll interacting protein multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in increased expression of TOLLIP mRNA CTD PMID:27738319 NCBI chr 1:214,823,993...214,844,861
Ensembl chr 1:214,823,978...214,844,858 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 ISO Erlotinib Hydrochloride promotes the reaction [Arsenic Trioxide results in increased expression of TP53 mRNA]; Erlotinib Hydrochloride promotes the reaction [Resveratrol results in increased expression of TP53 protein]; Resveratrol promotes the reaction [Erlotinib Hydrochloride results in increased expression of TP53 protein] CTD PMID:25895606 PMID:29274334 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in increased expression of TRAF6 mRNA CTD PMID:27738319 NCBI chr 3:91,252,829...91,271,607
Ensembl chr 3:91,252,829...91,271,607 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 increases expression
decreases response to substance
multiple interactions		 ISO Erlotinib Hydrochloride results in increased expression of TWIST1 protein
TWIST1 protein results in decreased susceptibility to Erlotinib Hydrochloride
[TWIST1 protein results in decreased susceptibility to Erlotinib Hydrochloride] which results in decreased cleavage of PARP1 protein; TWIST1 protein inhibits the reaction [Erlotinib Hydrochloride results in increased cleavage of PARP1 protein]
[TWIST1 protein results in decreased susceptibility to Erlotinib Hydrochloride] which results in decreased cleavage of CASP3 protein		 CTD PMID:30171258 NCBI chr 6:53,401,241...53,403,235
Ensembl chr 6:53,401,109...53,403,214 		JBrowse link
G Tyms thymidylate synthetase decreases expression
multiple interactions		 ISO Erlotinib Hydrochloride results in decreased expression of TYMS protein
betulinic acid promotes the reaction [Erlotinib Hydrochloride results in decreased expression of TYMS protein]; Erlotinib Hydrochloride promotes the reaction [betulinic acid results in decreased expression of TYMS protein]		 CTD PMID:30136359 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564 		JBrowse link
G Ulbp1 UL16 binding protein 1 increases expression
multiple interactions		 ISO Erlotinib Hydrochloride results in increased expression of ULBP1 mRNA; Erlotinib Hydrochloride results in increased expression of ULBP1 protein
Erlotinib Hydrochloride inhibits the reaction [TFAP2A protein binds to ULBP1 promoter]; Tetradecanoylphorbol Acetate inhibits the reaction [Erlotinib Hydrochloride inhibits the reaction [TFAP2A protein binds to ULBP1 promoter]]; Tetradecanoylphorbol Acetate inhibits the reaction [Erlotinib Hydrochloride results in increased expression of ULBP1 mRNA]		 CTD PMID:21499124 PMID:21951556 NCBI chr 1:1,181,301...1,200,526
Ensembl chr 1:1,180,932...1,220,916 		JBrowse link
G Xbp1 X-box binding protein 1 increases expression EXP Erlotinib Hydrochloride results in increased expression of XBP1 protein modified form CTD PMID:24768708 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145 		JBrowse link
fingolimod hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions
increases expression		 ISO [Fingolimod Hydrochloride results in increased abundance of 27-hydroxycholesterol] which results in increased expression of ABCA1 mRNA; NPC1 protein affects the reaction [Fingolimod Hydrochloride results in increased expression of ABCA1 protein]; UVI 3003 inhibits the reaction [Fingolimod Hydrochloride results in increased expression of ABCA1 protein]
Fingolimod Hydrochloride results in increased expression of ABCA1 mRNA; Fingolimod Hydrochloride results in increased expression of ABCA1 protein		 CTD PMID:20056921 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of ACTA2 mRNA]; Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of ACTA2 protein] CTD PMID:24893116 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394 		JBrowse link
G Adm adrenomedullin multiple interactions EXP Fingolimod Hydrochloride promotes the reaction [Mercuric Chloride results in increased expression of ADM mRNA]; Fingolimod Hydrochloride promotes the reaction [Mercuric Chloride results in increased expression of ADM protein] CTD PMID:15680492 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation		 ISO Acetylcysteine inhibits the reaction [Fingolimod Hydrochloride results in decreased phosphorylation of AKT1 protein]; pifithrin inhibits the reaction [Fingolimod Hydrochloride results in decreased phosphorylation of AKT1 protein]; pyrazolanthrone inhibits the reaction [Fingolimod Hydrochloride results in decreased phosphorylation of AKT1 protein] CTD PMID:25939952 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO Fingolimod Hydrochloride promotes the reaction [APOA1 protein results in increased secretion of Cholesterol] CTD PMID:20056921 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875 		JBrowse link
G Atg12 autophagy related 12 increases expression ISO Fingolimod Hydrochloride results in increased expression of ATG12 protein CTD PMID:25939952 NCBI chr18:40,721,799...40,732,143
Ensembl chr18:40,721,800...40,732,126 		JBrowse link
G Atg3 autophagy related 3 increases expression ISO Fingolimod Hydrochloride results in increased expression of ATG3 protein CTD PMID:25939952 NCBI chr11:60,585,192...60,613,706
Ensembl chr11:60,585,171...60,613,718 		JBrowse link
G Atg5 autophagy related 5 increases expression ISO Fingolimod Hydrochloride results in increased expression of ATG5 protein CTD PMID:25939952 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140 		JBrowse link
G Atg7 autophagy related 7 increases expression ISO Fingolimod Hydrochloride results in increased expression of ATG7 protein CTD PMID:25939952 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124 		JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression ISO Fingolimod Hydrochloride results in increased expression of BDNF mRNA CTD PMID:24859201 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210 		JBrowse link
G Becn1 beclin 1 multiple interactions ISO BECN1 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of BECN1 protein]; Fingolimod Hydrochloride results in increased expression of and results in increased cleavage of BECN1 protein CTD PMID:25939952 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases cleavage		 ISO 3-methyladenine inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of CASP3 protein]
Fingolimod Hydrochloride results in increased activity of CASP3 protein		 CTD PMID:25939952 PMID:29654831 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp8 caspase 8 increases cleavage
multiple interactions		 ISO Fingolimod Hydrochloride results in increased cleavage of CASP8 protein
SQSTM1 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of CASP8 protein]		 CTD PMID:25939952 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases response to substance
increases expression		 ISO 3-amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid inhibits the reaction [Fingolimod Hydrochloride results in increased expression of CCL2 protein]
CCL2 results in increased susceptibility to Fingolimod Hydrochloride		 CTD PMID:23043544 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions		 ISO Fingolimod Hydrochloride results in decreased expression of CCND1 mRNA
Estradiol inhibits the reaction [Fingolimod Hydrochloride results in decreased expression of CCND1 mRNA]; Fingolimod Hydrochloride inhibits the reaction [Estradiol results in decreased expression of CCND1 mRNA]		 CTD PMID:29654831 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Ccng2 cyclin G2 increases expression ISO Fingolimod Hydrochloride results in increased expression of CCNG2 mRNA CTD PMID:24356939 NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of COL1A1 mRNA] CTD PMID:24893116 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789 		JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of COL3A1 mRNA] CTD PMID:24893116 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217 		JBrowse link
G Comt catechol-O-methyltransferase increases expression ISO Fingolimod Hydrochloride results in increased expression of COMT mRNA CTD PMID:29654831 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 multiple interactions
decreases expression		 ISO Fingolimod Hydrochloride inhibits the reaction [Estradiol results in increased expression of CXCR4 mRNA]
Fingolimod Hydrochloride results in decreased expression of CXCR4 mRNA		 CTD PMID:29654831 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases expression ISO Fingolimod Hydrochloride results in decreased expression of CYP19A1 mRNA CTD PMID:29654831 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression ISO Fingolimod Hydrochloride results in decreased expression of CYP1A1 mRNA CTD PMID:29654831 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases expression ISO Fingolimod Hydrochloride results in decreased expression of CYP1B1 mRNA CTD PMID:29654831 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Estradiol results in increased expression of ESR1 protein] CTD PMID:29654831 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
decreases expression		 ISO Fingolimod Hydrochloride inhibits the reaction [Estradiol results in increased expression of ESR2 protein]
Fingolimod Hydrochloride results in decreased expression of ESR2 protein		 CTD PMID:29654831 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Fingolimod Hydrochloride results in increased expression of FOS mRNA CTD PMID:24859201 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Gnaq G protein subunit alpha q multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of GNAQ protein] CTD PMID:25980589 NCBI chr 1:233,382,778...233,622,584
Ensembl chr 1:233,382,708...233,622,786 		JBrowse link
G Hdac1 histone deacetylase 1 affects binding
multiple interactions		 ISO Fingolimod Hydrochloride metabolite binds to HDAC1 protein
Fingolimod Hydrochloride metabolite inhibits the reaction [S1PR1 protein binds to HDAC1 protein]; SPHK2 protein promotes the reaction [Fingolimod Hydrochloride metabolite binds to HDAC1 protein]		 CTD PMID:24859201 NCBI chr 5:147,716,664...147,743,723
Ensembl chr 5:147,716,664...147,743,723 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO Fingolimod Hydrochloride results in increased expression of HMGCR mRNA CTD PMID:24356939 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Fingolimod Hydrochloride results in increased expression of HMGCS1 mRNA CTD PMID:24356939 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression ISO Fingolimod Hydrochloride results in increased expression of IDI1 mRNA CTD PMID:24356939 NCBI chr17:57,976,266...57,984,036
Ensembl chr17:57,976,268...57,984,036 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of IL1B protein] CTD PMID:24893116 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of IL6 protein] CTD PMID:24893116 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Fingolimod Hydrochloride results in decreased activity of KCNH2 protein CTD PMID:25223691 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253 		JBrowse link
G Klhl24 kelch-like family member 24 increases expression ISO Fingolimod Hydrochloride results in increased expression of KLHL24 mRNA CTD PMID:24356939 NCBI chr11:84,613,101...84,643,674
Ensembl chr11:84,615,760...84,633,504 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Fingolimod Hydrochloride results in increased phosphorylation of MAPK1 protein CTD PMID:25939952 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Fingolimod Hydrochloride results in increased phosphorylation of MAPK3 protein CTD PMID:25939952 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA]; Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein] CTD PMID:25980589 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO Fingolimod Hydrochloride results in decreased phosphorylation of MTOR protein CTD PMID:25939952 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967 		JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 multiple interactions
increases expression		 ISO NPC1 protein affects the reaction [Fingolimod Hydrochloride results in increased expression of ABCA1 protein]
Fingolimod Hydrochloride results in increased expression of NPC1 protein		 CTD PMID:20056921 NCBI chr18:3,616,878...3,662,656
Ensembl chr18:3,616,878...3,662,683 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 ISO 3-methyladenine inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; BECN1 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; necrostatin-1 inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; RIPK3 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; SQSTM1 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein] CTD PMID:25939952 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Pdcd4 programmed cell death 4 increases expression ISO Fingolimod Hydrochloride results in increased expression of PDCD4 mRNA CTD PMID:24356939 NCBI chr 1:274,616,625...274,648,204
Ensembl chr 1:274,625,224...274,648,204 		JBrowse link
G Plcb4 phospholipase C, beta 4 multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of PLCB4 protein] CTD PMID:25980589 NCBI chr 3:128,601,163...128,971,720
Ensembl chr 3:128,756,799...128,971,746 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions
increases expression		 ISO necrostatin-1 inhibits the reaction [Fingolimod Hydrochloride results in increased expression of RIPK1 protein] CTD PMID:25939952 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 increases expression
multiple interactions		 ISO Fingolimod Hydrochloride results in increased expression of RIPK3 protein
RIPK3 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; RIPK3 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased phosphorylation of TP53 protein]		 CTD PMID:25939952 NCBI chr15:34,470,796...34,479,741
Ensembl chr15:34,470,796...34,479,741 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO Fingolimod Hydrochloride results in decreased phosphorylation of RPS6KB1 protein CTD PMID:25939952 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364 		JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 multiple interactions
decreases activity
decreases expression		 ISO Fingolimod Hydrochloride inhibits the reaction [SPHK2 protein results in increased expression of S1PR1 protein]; Fingolimod Hydrochloride metabolite inhibits the reaction [S1PR1 protein binds to HDAC1 protein]
Fingolimod Hydrochloride analog results in decreased activity of S1PR1 protein
Fingolimod Hydrochloride results in decreased expression of S1PR1 protein
[3-amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid results in decreased activity of S1PR1 protein] which results in decreased susceptibility to Fingolimod Hydrochloride		 CTD PMID:23043544 PMID:24420784 PMID:24859201 NCBI chr 2:218,654,406...218,658,761
Ensembl chr 2:218,654,554...218,658,761 		JBrowse link
G S1pr3 sphingosine-1-phosphate receptor 3 multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of S1PR3 protein] CTD PMID:25980589 NCBI chr17:13,799,383...13,812,877
Ensembl chr17:13,799,383...13,812,704 		JBrowse link
G Sphk2 sphingosine kinase 2 multiple interactions
increases response to substance
increases phosphorylation		 ISO Fingolimod Hydrochloride inhibits the reaction [SPHK2 protein results in increased expression of S1PR1 protein]; SPHK2 protein promotes the reaction [Fingolimod Hydrochloride metabolite binds to HDAC1 protein]
SPHK2 results in increased susceptibility to Fingolimod Hydrochloride
SPHK2 protein results in increased phosphorylation of Fingolimod Hydrochloride		 CTD PMID:23043544 PMID:24859201 NCBI chr 1:101,692,972...101,700,604
Ensembl chr 1:101,692,973...101,697,277 		JBrowse link
G Sqle squalene epoxidase increases expression ISO Fingolimod Hydrochloride results in increased expression of SQLE mRNA CTD PMID:24356939 NCBI chr 7:99,609,929...99,624,803
Ensembl chr 7:99,609,191...99,624,732 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
decreases expression		 ISO Fingolimod Hydrochloride affects the reaction [bafilomycin A1 results in increased expression of SQSTM1 protein]; SQSTM1 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of CASP8 protein]; SQSTM1 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]
Fingolimod Hydrochloride results in decreased expression of SQSTM1 protein		 CTD PMID:25939952 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294 		JBrowse link
G Tfe3 transcription factor binding to IGHM enhancer 3 decreases phosphorylation ISO Fingolimod Hydrochloride results in decreased phosphorylation of TFE3 protein CTD PMID:29945972 NCBI chr  X:15,574,579...15,587,826
Ensembl chr  X:15,575,934...15,587,419 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA] CTD PMID:24893116 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of TNF protein] CTD PMID:24893116 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases phosphorylation		 ISO Acetylcysteine inhibits the reaction [Fingolimod Hydrochloride results in increased phosphorylation of TP53 protein]; necrostatin-1 inhibits the reaction [Fingolimod Hydrochloride results in increased phosphorylation of TP53 protein]; pyrazolanthrone inhibits the reaction [Fingolimod Hydrochloride results in increased phosphorylation of TP53 protein]; RIPK3 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased phosphorylation of TP53 protein] CTD PMID:25939952 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of VEGFA mRNA] CTD PMID:24893116 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
G Vegfd vascular endothelial growth factor D increases expression ISO Fingolimod Hydrochloride results in increased expression of VEGFD mRNA CTD PMID:24859201 NCBI chr  X:31,816,480...31,852,239
Ensembl chr  X:31,816,436...31,851,715 		JBrowse link
fluoxetine hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc6a4 solute carrier family 6 member 4 decreases expression EXP fluoxetine decreases expression of Slc6a4 mRNA in the dorsal raphe nucleus RGD PMID:15936043 RGD:38549581 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463 		JBrowse link
lurasidone hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd2 dopamine receptor D2 multiple interactions ISO Lurasidone Hydrochloride binds to and results in decreased activity of DRD2 protein CTD PMID:20404009 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions ISO Lurasidone Hydrochloride binds to and results in increased activity of HTR1A protein CTD PMID:20404009 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896 		JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 multiple interactions ISO Lurasidone Hydrochloride binds to and results in decreased activity of HTR7 protein CTD PMID:20404009 NCBI chr 1:254,547,964...254,671,811
Ensembl chr 1:254,547,620...254,671,778 		JBrowse link
methoctramine tetrahydrochloride term browser