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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hydroxypregnenolone
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Accession:CHEBI:36730 term browser browse the term
Definition:A C21-steroid that is pregnenolone in which a hydrogen attached to a carbon is substituted by a hydroxy group.
Synonyms:related_synonym: Formula=C21H32O3



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17alpha-hydroxypregnenolone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 affects chemical synthesis
affects metabolic processing
decreases acetylation
multiple interactions
increases metabolic processing
ISO CYP17A1 protein affects the chemical synthesis of 17-alpha-Hydroxypregnenolone
CYP17A1 protein affects the metabolism of 17-alpha-Hydroxypregnenolone
CYP17A1 protein results in decreased acetylation of 17-alpha-Hydroxypregnenolone
[[abiraterone results in decreased activity of CYP17A1 protein] which results in decreased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone; [CYP17A1 protein results in increased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone; [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone; Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone]; Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone]; Duloxetine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone]; Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone]; Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone]; Venlafaxine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone]
CTD PMID:15562394 PMID:16030167 PMID:17194026 PMID:29100959 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20050
    chemical entity 20049
      group 19976
        inorganic group 19464
          oxo group 18872
            organic oxo compound 18872
              carbonyl compound 18872
                ketone 17097
                  hydroxypregnenolone 1
                    16alpha,17alpha-dihydroxypregnenolone 0
                    16alpha-hydroxypregnenolone 0
                    17alpha-hydroxypregnenolone + 1
                    21-hydroxypregnenolone + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20050
    subatomic particle 20048
      composite particle 20048
        hadron 20048
          baryon 20048
            nucleon 20048
              atomic nucleus 20048
                atom 20048
                  main group element atom 19948
                    p-block element atom 19948
                      carbon group element atom 19872
                        carbon atom 19863
                          organic molecular entity 19863
                            organic molecule 19809
                              organic cyclic compound 19572
                                organic polycyclic compound 16967
                                  steroid 13376
                                    hydroxy steroid 13005
                                      3-hydroxy steroid 10393
                                        3beta-hydroxy steroid 2022
                                          3beta-hydroxy-Delta(5)-steroid 1853
                                            pregnenolone 1567
                                              hydroxypregnenolone 1
                                                16alpha,17alpha-dihydroxypregnenolone 0
                                                16alpha-hydroxypregnenolone 0
                                                17alpha-hydroxypregnenolone + 1
                                                21-hydroxypregnenolone + 0
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