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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
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Accession:CHEBI:36707 term browser browse the term
Definition:A 2-acyl-1-alkyl-sn-glycero-3-phosphocholine where the 2-O-acyl group is specified as acetyl; a potent phospholipid activator and mediator of many leukocyte functions, including platelet aggregation, inflammation, and anaphylaxis.
Synonyms:related_synonym: 1-alkyl-2-acetyl-sn-glycero-3-phosphocholines;   2-acetyl-1-alkyl-sn-glycero-3-phosphocholine zwitterion;   Formula=C10H21NO7PR;   SMILES=CC(=O)O[C@H](CO[*])COP([O-])(=O)OCC[N+](C)(C)C;   a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine;   platelet-activating factor
 alt_id: CHEBI:11238;   CHEBI:11496;   CHEBI:19004;   CHEBI:19434;   CHEBI:595;   CHEBI:63915;   MESH:D010972
 xref: KEGG:C04598
 xref_mesh: MESH:D010972
 xref: PMID:7639802


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2-acetyl-1-alkyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGTR1 angiotensin II receptor type 1 increases expression EXP Platelet Activating Factor results in increased expression of AGTR1 mRNA CTD PMID:16386258 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008
JBrowse link
G ALOX12 arachidonate 12-lipoxygenase, 12S type increases expression EXP Platelet Activating Factor results in increased expression of ALOX12 mRNA CTD PMID:16386258 NCBI chr17:6,993,791...7,010,754
Ensembl chr17:6,996,049...7,010,754
JBrowse link
G ALOX5 arachidonate 5-lipoxygenase increases expression
multiple interactions
EXP Platelet Activating Factor results in increased expression of ALOX5 mRNA
[sodium arsenite co-treated with Platelet Activating Factor co-treated with Arachidonic Acid] results in increased phosphorylation of and results in increased activity of ALOX5 protein; [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Calcimycin results in increased abundance of Platelet Activating Factor]
CTD PMID:8387780 PMID:10779545 PMID:16386258 NCBI chr10:45,374,209...45,446,121
Ensembl chr10:45,374,176...45,446,119
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions
increases secretion
EXP Foropafant inhibits the reaction [Platelet Activating Factor results in increased secretion of CCL2 protein] CTD PMID:15149885 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CCR2 C-C motif chemokine receptor 2 increases expression EXP Platelet Activating Factor results in increased expression of CCR2 mRNA CTD PMID:16386258 NCBI chr 3:46,354,111...46,360,940
Ensembl chr 3:46,353,864...46,360,940
JBrowse link
G CRP C-reactive protein increases expression EXP Platelet Activating Factor results in increased expression of CRP mRNA CTD PMID:16386258 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589
JBrowse link
G CX3CR1 C-X3-C motif chemokine receptor 1 increases expression EXP Platelet Activating Factor results in increased expression of CX3CR1 mRNA CTD PMID:16386258 NCBI chr 3:39,263,494...39,281,735
Ensembl chr 3:39,263,495...39,281,735
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions
increases secretion
EXP Foropafant inhibits the reaction [Platelet Activating Factor results in increased secretion of CXCL8 protein] CTD PMID:15149885 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G EDN1 endothelin 1 multiple interactions
increases abundance
ISO Carbon Tetrachloride promotes the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor]; EDNRB protein affects the reaction [Carbon Tetrachloride promotes the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor]]; EDNRB protein affects the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor] CTD PMID:18205269 NCBI chr 6:12,256,463...12,297,194
Ensembl chr 6:12,290,361...12,297,194
JBrowse link
G EDNRB endothelin receptor type B multiple interactions ISO EDNRB protein affects the reaction [Carbon Tetrachloride promotes the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor]]; EDNRB protein affects the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor] CTD PMID:18205269 NCBI chr13:77,895,481...77,975,527
Ensembl chr13:77,895,481...77,975,529
JBrowse link
G EGR1 early growth response 1 increases expression EXP Platelet Activating Factor results in increased expression of EGR1 mRNA CTD PMID:16386258 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
JBrowse link
G GUSB glucuronidase beta multiple interactions ISO [Platelet Activating Factor co-treated with Cytochalasin B] results in increased secretion of GUSB protein; IMMLG5521 inhibits the reaction [[Platelet Activating Factor co-treated with Cytochalasin B] results in increased secretion of GUSB protein] CTD PMID:23850278 NCBI chr 7:65,960,684...65,982,230
Ensembl chr 7:65,960,684...65,982,215
JBrowse link
G IL1A interleukin 1 alpha increases expression EXP Platelet Activating Factor results in increased expression of IL1A mRNA CTD PMID:16386258 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G IL1B interleukin 1 beta increases expression
multiple interactions
increases secretion
EXP Platelet Activating Factor results in increased expression of IL1B mRNA
[Platelet Activating Factor co-treated with MIR149 mRNA] affects the secretion of IL1B protein; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased secretion of IL1B protein]
CTD PMID:16386258 PMID:32830409 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 increases secretion
multiple interactions
EXP Platelet Activating Factor results in increased secretion of IL6 protein
[Platelet Activating Factor co-treated with MIR149 mRNA] affects the secretion of IL6 protein; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased secretion of IL6 protein]
CTD PMID:32830409 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G ITGAM integrin subunit alpha M multiple interactions
increases expression
EXP Foropafant inhibits the reaction [Platelet Activating Factor results in increased expression of ITGAM protein]; Isoproterenol promotes the reaction [Theophylline inhibits the reaction [Platelet Activating Factor results in increased expression of ITGAM protein]]; Theophylline inhibits the reaction [Platelet Activating Factor results in increased expression of ITGAM protein] CTD PMID:9762784 PMID:11116075 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892
JBrowse link
G LTB4R leukotriene B4 receptor affects response to substance ISO LTB4R1 protein affects the susceptibility to Platelet Activating Factor CTD PMID:10934231 NCBI chr14:24,311,502...24,318,036
Ensembl chr14:24,311,450...24,318,036
JBrowse link
G MIR149 microRNA 149 decreases expression
multiple interactions
EXP Platelet Activating Factor results in decreased expression of MIR149 mRNA
[Platelet Activating Factor co-treated with MIR149 mRNA] affects the secretion of IL1B protein; [Platelet Activating Factor co-treated with MIR149 mRNA] affects the secretion of IL6 protein; [Platelet Activating Factor co-treated with MIR149 mRNA] affects the secretion of TNF protein; [Platelet Activating Factor co-treated with PVT1 mRNA] affects the expression of MIR149 mRNA
CTD PMID:32830409 NCBI chr 2:240,456,001...240,456,089
Ensembl chr 2:240,456,001...240,456,089
JBrowse link
G MMP13 matrix metallopeptidase 13 increases expression EXP Platelet Activating Factor results in increased expression of MMP13 mRNA CTD PMID:16386258 NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732
JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor increases expression
multiple interactions
EXP Platelet Activating Factor results in increased expression of MYD88 protein
PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased expression of MYD88 protein]
CTD PMID:32830409 NCBI chr 3:38,138,661...38,143,022
Ensembl chr 3:38,138,478...38,143,022
JBrowse link
G NCEH1 neutral cholesterol ester hydrolase 1 multiple interactions ISO NCEH1 protein inhibits the reaction [[Chlorpyrifos metabolite co-treated with Cytidine Diphosphate Choline] results in increased abundance of Platelet Activating Factor] CTD PMID:18164358 NCBI chr 3:172,630,249...172,711,067
Ensembl chr 3:172,630,249...172,711,218
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions
increases degradation
ISO Acetylcysteine inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; BN 50739 inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; Genistein inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; herbimycin inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; Vitamin E inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein] CTD PMID:10921504 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,513...35,404,749
JBrowse link
G OLR1 oxidized low density lipoprotein receptor 1 increases expression EXP Platelet Activating Factor results in increased expression of OLR1 mRNA CTD PMID:16386258 NCBI chr12:10,158,301...10,172,132
Ensembl chr12:10,158,301...10,172,138
JBrowse link
G PLA2G7 phospholipase A2 group VII multiple interactions
increases expression
EXP [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Platelet Activating Factor] results in increased expression of PLA2G7 mRNA; bepafant inhibits the reaction [Platelet Activating Factor results in increased expression of PLA2G7 mRNA] CTD PMID:21432021 NCBI chr 6:46,700,558...46,735,836
Ensembl chr 6:46,704,201...46,735,693
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha decreases expression EXP Platelet Activating Factor results in decreased expression of PPARA mRNA CTD PMID:16386258 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
G PTAFR platelet activating factor receptor multiple interactions
increases expression
increases phosphorylation
affects binding
EXP
ISO
1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]; BN 50730 inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]; BN 50739 inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]; CMI 392 inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]; MK 287 inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]; zileuton inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]
Platelet Activating Factor results in increased expression of PTAFR mRNA
Platelet Activating Factor results in increased phosphorylation of PTAFR protein
bepafant inhibits the reaction [Platelet Activating Factor results in increased expression of PTAFR mRNA]; Carbon Tetrachloride promotes the reaction [Platelet Activating Factor binds to PTAFR protein]; RGS4 protein inhibits the reaction [Platelet Activating Factor results in increased phosphorylation of PTAFR protein]; TNF protein affects the reaction [Platelet Activating Factor results in increased expression of PTAFR mRNA]
CTD PMID:9065783 PMID:10447766 PMID:11297424 PMID:11529688 PMID:16386258 PMID:18205269 NCBI chr 1:28,147,166...28,193,856
Ensembl chr 1:28,147,166...28,193,936
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 increases expression EXP Platelet Activating Factor results in increased expression of PTGS1 mRNA CTD PMID:16386258 NCBI chr 9:122,369,906...122,395,703
Ensembl chr 9:122,370,530...122,395,703
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression EXP Platelet Activating Factor results in increased expression of PTGS2 mRNA CTD PMID:16386258 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G PVT1 Pvt1 oncogene increases expression
multiple interactions
EXP Platelet Activating Factor results in increased expression of PVT1 mRNA
[Platelet Activating Factor co-treated with PVT1 mRNA] affects the expression of MIR149 mRNA; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased expression of MYD88 protein]; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased secretion of IL1B protein]; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased secretion of IL6 protein]; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased secretion of TNF protein]
CTD PMID:32830409 NCBI chr 8:127,794,533...128,101,253
Ensembl chr 8:127,794,526...128,187,101
JBrowse link
G RGS4 regulator of G protein signaling 4 multiple interactions ISO RGS4 protein inhibits the reaction [Platelet Activating Factor results in increased phosphorylation of PTAFR protein] CTD PMID:11297424 NCBI chr 1:163,068,871...163,076,802
Ensembl chr 1:163,068,775...163,076,802
JBrowse link
G SELE selectin E increases expression EXP Platelet Activating Factor results in increased expression of SELE mRNA CTD PMID:16386258 NCBI chr 1:169,722,640...169,734,079
Ensembl chr 1:169,722,640...169,764,705
JBrowse link
G SELL selectin L multiple interactions
increases secretion
EXP Isoproterenol promotes the reaction [Theophylline inhibits the reaction [Platelet Activating Factor results in increased secretion of SELL protein]]; Theophylline inhibits the reaction [Platelet Activating Factor results in increased secretion of SELL protein] CTD PMID:9762784 NCBI chr 1:169,690,667...169,711,620
Ensembl chr 1:169,690,665...169,711,702
JBrowse link
G SELP selectin P multiple interactions
increases expression
EXP Foropafant inhibits the reaction [Platelet Activating Factor results in increased expression of SELP protein] CTD PMID:11116075 NCBI chr 1:169,588,849...169,630,125
Ensembl chr 1:169,588,849...169,630,193
JBrowse link
G TIMP4 TIMP metallopeptidase inhibitor 4 increases expression EXP Platelet Activating Factor results in increased expression of TIMP4 mRNA CTD PMID:16386258 NCBI chr 3:12,153,068...12,158,912
Ensembl chr 3:12,153,068...12,158,912
JBrowse link
G TNF tumor necrosis factor increases secretion
multiple interactions
increases expression
EXP
ISO
Platelet Activating Factor results in increased secretion of TNF protein
[Platelet Activating Factor co-treated with MIR149 mRNA] affects the secretion of TNF protein; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased secretion of TNF protein]
TNF protein affects the reaction [Platelet Activating Factor results in increased expression of PTAFR mRNA]
Platelet Activating Factor results in increased expression of TNF mRNA
Acetylcysteine inhibits the reaction [Platelet Activating Factor results in increased expression of TNF mRNA]; BN 50739 inhibits the reaction [Platelet Activating Factor results in increased expression of TNF mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Platelet Activating Factor results in increased expression of TNF mRNA]; Vitamin E inhibits the reaction [Platelet Activating Factor results in increased expression of TNF mRNA]
CTD PMID:9065783 PMID:10921504 PMID:16386258 PMID:32830409 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TNF tumor necrosis factor increases expression ISO platelet-activating factor increases expression of Tnf protein in portal stenosis rat plasma RGD PMID:10452877 RGD:38508900 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 24815
    chemical entity 24785
      molecular entity 24749
        ion 17243
          organic ion 8786
            organic cation 7518
              quaternary ammonium ion 5190
                quaternary nitrogen compound 639
                  ammonium betaine 340
                    2-acetyl-1-alkyl-sn-glycero-3-phosphocholine 35
                      1-[(9Z)-hexadecenyl]-2-acetyl-sn-glycero-3-phosphocholine 0
                      1-decyl-2-acetyl-sn-glycero-3-phosphocholine 0
                      1-dodecyl-2-acetyl-sn-glycero-3-phosphocholine 0
                      1-tetradecyl-2-acetyl-sn-glycero-3-phosphocholine 0
                      2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine 0
                      2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 24815
    subatomic particle 24774
      composite particle 24774
        hadron 24774
          baryon 24774
            nucleon 24774
              atomic nucleus 24774
                atom 24774
                  main group element atom 24641
                    p-block element atom 24641
                      chalcogen 23783
                        oxygen atom 23669
                          oxygen molecular entity 23669
                            hydroxides 22930
                              oxoacid 22138
                                pnictogen oxoacid 11157
                                  phosphorus oxoacid 9999
                                    phosphoric acids 8794
                                      phosphoric acid 8794
                                        phosphoric acid derivative 8488
                                          phosphate 8488
                                            organic phosphate 8487
                                              phospholipid 309
                                                glycerophospholipid 208
                                                  glycerophosphocholine 121
                                                    alkylacylglycero-3-phosphocholine 35
                                                      alkyl,acyl-sn-glycero-3-phosphocholine 35
                                                        2-acyl-1-alkyl-sn-glycero-3-phosphocholine 35
                                                          2-acetyl-1-alkyl-sn-glycero-3-phosphocholine 35
                                                            1-[(9Z)-hexadecenyl]-2-acetyl-sn-glycero-3-phosphocholine 0
                                                            1-decyl-2-acetyl-sn-glycero-3-phosphocholine 0
                                                            1-dodecyl-2-acetyl-sn-glycero-3-phosphocholine 0
                                                            1-tetradecyl-2-acetyl-sn-glycero-3-phosphocholine 0
                                                            2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine 0
                                                            2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine 1
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