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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions increases phosphorylation |
ISO |
epigallocatechin gallate inhibits the reaction [Imiquimod results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:24990399 PMID:29402411 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Apex1 |
apurinic/apyrimidinic endodeoxyribonuclease 1 |
decreases expression |
ISO |
imiquimod results in decreased expression of APEX1 mRNA |
CTD |
PMID:21878529 |
|
NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
imiquimod results in decreased expression of BCL2 protein |
CTD |
PMID:20033192 |
|
NCBI chr13:22,689,783...22,853,920
|
|
G |
Blm |
BLM RecQ like helicase |
decreases expression |
ISO |
imiquimod results in decreased expression of BLM mRNA |
CTD |
PMID:21878529 |
|
NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312
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G |
Brca2 |
BRCA2, DNA repair associated |
decreases expression |
ISO |
imiquimod results in decreased expression of BRCA2 mRNA |
CTD |
PMID:21878529 |
|
NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567
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|
G |
Bst2 |
bone marrow stromal cell antigen 2 |
increases expression |
ISO |
Imiquimod results in increased expression of BST2 protein |
CTD |
PMID:31093508 |
|
NCBI chr16:18,217,404...18,220,979
Ensembl chr16:18,217,407...18,220,979
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|
G |
Casp1 |
caspase 1 |
increases activity multiple interactions |
ISO |
Imiquimod results in increased activity of CASP1 protein [Dronabinol inhibits the reaction [Imiquimod results in increased activity of CASP1 protein]] which affects the localization of IL1B protein; Dronabinol inhibits the reaction [Imiquimod results in increased activity of CASP1 protein] |
CTD |
PMID:31383729 |
|
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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|
G |
Casp3 |
caspase 3 |
increases activity increases cleavage |
ISO |
imiquimod results in increased activity of CASP3 protein imiquimod results in increased cleavage of CASP3 protein |
CTD |
PMID:12902443 PMID:20033192 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
increases secretion |
ISO |
Imiquimod results in increased secretion of CCL2 protein |
CTD |
PMID:34740670 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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|
G |
Cd274 |
CD274 molecule |
increases expression |
ISO |
Imiquimod results in increased expression of CD274 protein |
CTD |
PMID:31093508 |
|
NCBI chr 1:227,116,627...227,137,379
Ensembl chr 1:227,116,649...227,134,450
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|
G |
Cd40 |
CD40 molecule |
increases expression multiple interactions |
ISO |
Imiquimod results in increased expression of CD40 protein LGMN gene mutant form inhibits the reaction [Imiquimod results in increased expression of CD40 protein] |
CTD |
PMID:22916010 PMID:31093508 |
|
NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
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|
G |
Cd80 |
Cd80 molecule |
increases expression |
ISO |
Imiquimod results in increased expression of CD80 protein |
CTD |
PMID:31093508 |
|
NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
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|
G |
Cd86 |
CD86 molecule |
multiple interactions increases expression |
ISO |
[Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of CD86 protein; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased expression of CD86 protein]; Tetrachlorodibenzodioxin promotes the reaction [[Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of CD86 protein] |
CTD |
PMID:21097750 PMID:22916010 PMID:31093508 |
|
NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
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|
G |
Chaf1a |
chromatin assembly factor 1 subunit A |
decreases expression |
ISO |
imiquimod results in decreased expression of CHAF1A mRNA |
CTD |
PMID:21878529 |
|
NCBI chr 9:873,953...900,701
Ensembl chr 9:874,051...900,654
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|
G |
Chaf1b |
chromatin assembly factor 1 subunit B |
decreases expression |
ISO |
imiquimod results in decreased expression of CHAF1B mRNA |
CTD |
PMID:21878529 |
|
NCBI chr11:33,200,894...33,221,076
Ensembl chr11:33,200,981...33,221,070
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|
G |
Ctsb |
cathepsin B |
increases activity |
ISO |
Imiquimod results in increased activity of CTSB protein |
CTD |
PMID:22916010 |
|
NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
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|
G |
Ctsk |
cathepsin K |
increases activity |
ISO |
Imiquimod results in increased activity of CTSK protein |
CTD |
PMID:22916010 |
|
NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
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G |
Ctsl |
cathepsin L |
increases activity |
ISO |
Imiquimod results in increased activity of CTSL protein |
CTD |
PMID:22916010 |
|
NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
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G |
Ctss |
cathepsin S |
increases activity |
ISO |
Imiquimod results in increased activity of CTSS protein |
CTD |
PMID:22916010 |
|
NCBI chr 2:183,089,192...183,114,483
Ensembl chr 2:183,086,437...183,114,483
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|
G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
multiple interactions |
ISO |
[Pam(3)CSK(4) peptide co-treated with Antigens, Bacterial co-treated with Poly I-C co-treated with Lipopolysaccharides co-treated with FSL-1 lipoprotein, synthetic co-treated with imiquimod co-treated with Polyribonucleotides co-treated with ProMune] results in increased expression of CXCL10 protein; Particulate Matter inhibits the reaction [[Pam(3)CSK(4) peptide co-treated with Antigens, Bacterial co-treated with Poly I-C co-treated with Lipopolysaccharides co-treated with FSL-1 lipoprotein, synthetic co-treated with imiquimod co-treated with Polyribonucleotides co-treated with ProMune] results in increased expression of CXCL10 protein]; Vehicle Emissions inhibits the reaction [[Pam(3)CSK(4) peptide co-treated with Antigens, Bacterial co-treated with Poly I-C co-treated with Lipopolysaccharides co-treated with FSL-1 lipoprotein, synthetic co-treated with imiquimod co-treated with Polyribonucleotides co-treated with ProMune] results in increased expression of CXCL10 protein] |
CTD |
PMID:28655636 |
|
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
increases secretion |
ISO |
Imiquimod results in increased secretion of CXCL1 protein |
CTD |
PMID:22916010 |
|
NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
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|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases metabolic processing multiple interactions affects metabolic processing increases chemical synthesis |
ISO |
CYP1A1 protein results in increased metabolism of Imiquimod CYP1A1 protein affects the reaction [beta-Naphthoflavone results in increased metabolism of Imiquimod] CYP1A1 protein affects the metabolism of Imiquimod [CYP1A1 protein results in increased metabolism of Imiquimod] which results in increased chemical synthesis of Imiquimod metabolite CYP1A1 protein results in increased chemical synthesis of Imiquimod metabolite |
CTD |
PMID:31111189 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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|
G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions affects metabolic processing increases chemical synthesis increases metabolic processing |
ISO |
[CYP1A2 protein results in increased metabolism of Imiquimod] which results in increased chemical synthesis of Imiquimod metabolite CYP1A2 protein affects the metabolism of Imiquimod CYP1A2 protein results in increased chemical synthesis of Imiquimod metabolite CYP1A2 protein affects the reaction [beta-Naphthoflavone results in increased metabolism of Imiquimod] |
CTD |
PMID:31111189 |
|
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp2c6v1 |
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 |
increases metabolic processing |
ISO |
CYP2C19 protein results in increased metabolism of Imiquimod |
CTD |
PMID:31111189 |
|
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
increases metabolic processing |
ISO |
CYP2D6 protein results in increased metabolism of Imiquimod |
CTD |
PMID:31111189 |
|
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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G |
Ercc2 |
ERCC excision repair 2, TFIIH core complex helicase subunit |
decreases expression |
ISO |
imiquimod results in decreased expression of ERCC2 mRNA |
CTD |
PMID:21878529 |
|
NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102
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G |
Ercc5 |
ERCC excision repair 5, endonuclease |
increases expression |
ISO |
imiquimod results in increased expression of ERCC5 mRNA |
CTD |
PMID:21878529 |
|
NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472
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G |
Fancl |
FA complementation group L |
decreases expression |
ISO |
imiquimod results in decreased expression of FANCL mRNA |
CTD |
PMID:21878529 |
|
NCBI chr14:100,249,733...100,317,958
Ensembl chr14:100,248,875...100,314,255
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G |
Fbh1 |
F-box DNA helicase 1 |
decreases expression |
ISO |
imiquimod results in decreased expression of FBH1 mRNA |
CTD |
PMID:21878529 |
|
NCBI chr17:66,749,506...66,787,590
Ensembl chr17:66,749,534...66,787,590
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G |
Fgf2 |
fibroblast growth factor 2 |
decreases expression |
ISO |
imiquimod results in decreased expression of FGF2 |
CTD |
PMID:16368197 |
|
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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G |
Gtf2h3 |
general transcription factor IIH subunit 3 |
decreases expression |
ISO |
imiquimod results in decreased expression of GTF2H3 mRNA |
CTD |
PMID:21878529 |
|
NCBI chr12:32,009,010...32,025,484
Ensembl chr12:32,009,014...32,025,497
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G |
Gtf2h4 |
general transcription factor 2H subunit 4 |
decreases expression |
ISO |
imiquimod results in decreased expression of GTF2H4 mRNA |
CTD |
PMID:21878529 |
|
NCBI chr20:3,071,328...3,076,990
Ensembl chr20:3,071,328...3,076,984
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G |
Gzmb |
granzyme B |
multiple interactions |
ISO |
Imiquimod results in increased expression of and results in increased secretion of GZMB protein |
CTD |
PMID:31093508 |
|
NCBI chr15:30,343,361...30,346,792
Ensembl chr15:30,173,603...30,346,814
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G |
H2ax |
H2A.X variant histone |
decreases expression |
ISO |
Imiquimod results in decreased expression of H2AX mRNA |
CTD |
PMID:21878529 |
|
NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
[imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ICAM1 protein; Tetrachlorodibenzodioxin promotes the reaction [[imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ICAM1 protein] |
CTD |
PMID:21097750 |
|
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
[Hydroxychloroquine co-treated with Imiquimod] results in increased secretion of IL10 protein |
CTD |
PMID:31082466 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il11 |
interleukin 11 |
multiple interactions decreases expression |
ISO |
ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL11 mRNA] |
CTD |
PMID:31054998 |
|
NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129
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G |
Il11ra1 |
interleukin 11 receptor subunit alpha 1 |
multiple interactions decreases expression |
ISO |
ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL11RA1 mRNA] |
CTD |
PMID:31054998 |
|
NCBI chr 5:56,931,824...56,941,408
Ensembl chr 5:56,935,516...56,941,408
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|
G |
Il12a |
interleukin 12A |
multiple interactions increases secretion |
ISO |
[imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]; Tetrachlorodibenzodioxin inhibits the reaction [[imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]] Imiquimod results in increased secretion of IL12A protein |
CTD |
PMID:21097750 PMID:31093508 |
|
NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
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|
G |
Il12b |
interleukin 12B |
multiple interactions increases secretion increases expression |
ISO |
[Imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]; ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL12B mRNA]; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased secretion of IL12B protein]; Tetrachlorodibenzodioxin inhibits the reaction [[Imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]] |
CTD |
PMID:21097750 PMID:22916010 PMID:31054998 |
|
NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
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G |
Il13ra1 |
interleukin 13 receptor subunit alpha 1 |
multiple interactions increases expression |
ISO |
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL13RA1 mRNA] |
CTD |
PMID:31054998 |
|
NCBI chr X:115,348,860...115,408,682
Ensembl chr X:115,348,860...115,408,681
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G |
Il13ra2 |
interleukin 13 receptor subunit alpha 2 |
increases expression |
ISO |
Imiquimod results in increased expression of IL13RA2 mRNA |
CTD |
PMID:31054998 |
|
NCBI chr X:111,002,590...111,074,053
Ensembl chr X:111,002,592...111,072,381
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G |
Il17a |
interleukin 17A |
multiple interactions increases expression increases secretion |
ISO |
(+)-JQ1 compound inhibits the reaction [Imiquimod results in increased expression of IL17A mRNA]; (+)-JQ1 compound inhibits the reaction [Imiquimod results in increased secretion of IL17A protein]; ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL17A mRNA]; ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL17A protein]; Resveratrol inhibits the reaction [Imiquimod results in increased expression of IL17A mRNA]; SR 1078 inhibits the reaction [(+)-JQ1 compound inhibits the reaction [Imiquimod results in increased expression of IL17A mRNA]]; SR 1078 inhibits the reaction [(+)-JQ1 compound inhibits the reaction [Imiquimod results in increased secretion of IL17A protein]] Imiquimod results in increased expression of IL17A mRNA; Imiquimod results in increased expression of IL17A protein imiquimod results in increased secretion of IL17A protein |
CTD |
PMID:25965695 PMID:26149470 PMID:31054998 |
|
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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|
G |
Il17b |
interleukin 17B |
decreases expression multiple interactions |
ISO |
Imiquimod results in decreased expression of IL17B mRNA ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL17B mRNA] |
CTD |
PMID:31054998 |
|
NCBI chr18:55,141,194...55,145,565
Ensembl chr18:55,141,194...55,145,565
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G |
Il17rb |
interleukin 17 receptor B |
decreases expression multiple interactions |
ISO |
Imiquimod results in decreased expression of IL17RB mRNA ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL17RB mRNA] |
CTD |
PMID:31054998 |
|
NCBI chr16:5,180,431...5,194,125
Ensembl chr16:5,180,432...5,194,125
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|
G |
Il18 |
interleukin 18 |
increases expression multiple interactions |
ISO |
Imiquimod results in increased expression of IL18 mRNA ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL18 mRNA] |
CTD |
PMID:31054998 |
|
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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G |
Il18rap |
interleukin 18 receptor accessory protein |
multiple interactions increases expression |
ISO |
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL18RAP mRNA] |
CTD |
PMID:31054998 |
|
NCBI chr 9:42,768,112...42,800,964
Ensembl chr 9:42,768,220...42,800,959
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|
G |
Il19 |
interleukin 19 |
increases expression multiple interactions |
ISO |
imiquimod results in increased expression of IL19 mRNA resveratrol inhibits the reaction [imiquimod results in increased expression of IL19 mRNA] |
CTD |
PMID:25965695 |
|
NCBI chr13:42,397,715...42,411,637
Ensembl chr13:42,399,138...42,405,473
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G |
Il1a |
interleukin 1 alpha |
multiple interactions increases expression |
ISO |
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL1A mRNA] |
CTD |
PMID:31054998 |
|
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
increases secretion multiple interactions increases expression |
ISO |
Imiquimod results in increased secretion of IL1B protein [Dronabinol inhibits the reaction [Imiquimod results in increased activity of CASP1 protein]] which affects the localization of IL1B protein; Cannabidiol inhibits the reaction [Imiquimod results in increased secretion of IL1B protein]; Dronabinol inhibits the reaction [Imiquimod results in increased expression of IL1B mRNA]; Dronabinol inhibits the reaction [Imiquimod results in increased secretion of IL1B protein]; JHW 015 inhibits the reaction [Imiquimod results in increased secretion of IL1B protein] Imiquimod results in increased expression of IL1B mRNA; Imiquimod results in increased expression of IL1B protein ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL1B mRNA]; ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL1B protein] |
CTD |
PMID:18403674 PMID:31054998 PMID:31082466 PMID:31383729 PMID:34740670 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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|
G |
Il1f10 |
interleukin 1 family member 10 |
decreases expression multiple interactions |
ISO |
Imiquimod results in decreased expression of IL1F10 mRNA ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL1F10 mRNA] |
CTD |
PMID:31054998 |
|
NCBI chr 3:7,072,511...7,075,439
Ensembl chr 3:7,072,511...7,075,439
|
|
G |
Il1rap |
interleukin 1 receptor accessory protein |
increases expression |
ISO |
Imiquimod results in increased expression of IL1RAP mRNA |
CTD |
PMID:31054998 |
|
NCBI chr11:74,062,999...74,199,530
Ensembl chr11:74,070,304...74,199,530
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|
G |
Il2 |
interleukin 2 |
increases secretion |
ISO |
Imiquimod results in increased secretion of IL2 protein |
CTD |
PMID:34740670 |
|
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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|
G |
Il20 |
interleukin 20 |
increases expression multiple interactions |
ISO |
Imiquimod results in increased expression of IL20 mRNA ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL20 mRNA] |
CTD |
PMID:31054998 |
|
NCBI chr13:42,380,981...42,384,625
Ensembl chr13:42,380,981...42,384,625
|
|
G |
Il20rb |
interleukin 20 receptor subunit beta |
increases expression multiple interactions |
ISO |
Imiquimod results in increased expression of IL20RB mRNA ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL20RB mRNA] |
CTD |
PMID:31054998 |
|
NCBI chr 8:100,979,085...101,010,829
Ensembl chr 8:100,980,383...101,009,942
|
|
G |
Il22ra1 |
interleukin 22 receptor subunit alpha 1 |
increases expression multiple interactions |
ISO |
Imiquimod results in increased expression of IL22RA1 mRNA ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL22RA1 mRNA] |
CTD |
PMID:31054998 |
|
NCBI chr 5:147,961,496...147,986,296
Ensembl chr 5:147,961,349...147,986,296
|
|
G |
Il23a |
interleukin 23 subunit alpha |
increases secretion multiple interactions increases expression |
ISO |
imiquimod results in increased secretion of IL23A protein ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL23A mRNA]; ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL23A protein] Imiquimod results in increased expression of IL23A mRNA; Imiquimod results in increased expression of IL23A protein |
CTD |
PMID:25965695 PMID:26149470 PMID:31054998 |
|
NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
|
|
G |
Il27 |
interleukin 27 |
multiple interactions increases expression |
ISO |
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL27 mRNA] |
CTD |
PMID:31054998 |
|
NCBI chr 1:181,173,108...181,178,720
Ensembl chr 1:181,173,372...181,178,582
|
|
G |
Il33 |
interleukin 33 |
multiple interactions increases expression |
ISO |
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL33 mRNA] |
CTD |
PMID:31054998 |
|
NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
|
|
G |
Il36a |
interleukin 36, alpha |
increases expression multiple interactions |
ISO |
Imiquimod results in increased expression of IL36A mRNA ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL36A mRNA] |
CTD |
PMID:31054998 |
|
NCBI chr 3:6,996,851...7,001,400
Ensembl chr 3:6,996,851...7,001,400
|
|
G |
Il36b |
interleukin 36, beta |
increases expression multiple interactions |
ISO |
Imiquimod results in increased expression of IL36B mRNA ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL36B mRNA] |
CTD |
PMID:31054998 |
|
NCBI chr 3:7,024,862...7,122,489
Ensembl chr 3:7,021,973...7,031,619
|
|
G |
Il36g |
interleukin 36, gamma |
multiple interactions increases expression |
ISO |
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL36G mRNA] |
CTD |
PMID:31054998 |
|
NCBI chr 3:6,948,323...6,954,485
Ensembl chr 3:6,948,297...6,954,480
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|
G |
Il36rn |
interleukin 36 receptor antagonist |
multiple interactions increases expression |
ISO |
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL36RN mRNA] |
CTD |
PMID:31054998 |
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NCBI chr 3:7,044,419...7,051,016
Ensembl chr 3:7,044,406...7,051,016
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Il4 |
interleukin 4 |
increases secretion |
ISO |
Imiquimod results in increased secretion of IL4 protein |
CTD |
PMID:34740670 |
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NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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Il6 |
interleukin 6 |
multiple interactions increases secretion |
ISO |
[Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased secretion of IL6 protein; concanamycin B inhibits the reaction [Imiquimod results in increased secretion of IL6 protein]; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased secretion of IL6 protein]; MV026630 inhibits the reaction [Imiquimod results in increased secretion of IL6 protein] [Hydroxychloroquine co-treated with Imiquimod] results in increased secretion of IL6 protein; Cannabidiol promotes the reaction [Imiquimod results in increased secretion of IL6 protein] |
CTD |
PMID:21097750 PMID:22916010 PMID:31082466 PMID:31093508 PMID:31383729 PMID:34740670 More...
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Il7 |
interleukin 7 |
increases expression multiple interactions |
ISO |
Imiquimod results in increased expression of IL7 mRNA ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL7 mRNA] |
CTD |
PMID:31054998 |
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NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075
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Il7r |
interleukin 7 receptor |
multiple interactions increases expression |
ISO |
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL7R mRNA] |
CTD |
PMID:31054998 |
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NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757
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G |
Il9r |
interleukin 9 receptor |
decreases expression multiple interactions |
ISO |
Imiquimod results in decreased expression of IL9R mRNA ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL9R mRNA] |
CTD |
PMID:31054998 |
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NCBI chr10:15,431,706...15,444,144
Ensembl chr10:15,431,706...15,441,990
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G |
Irak2 |
interleukin-1 receptor-associated kinase 2 |
multiple interactions increases expression |
ISO |
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IRAK2 mRNA] |
CTD |
PMID:31054998 |
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NCBI chr 4:146,786,004...146,842,615
Ensembl chr 4:146,786,100...146,842,602
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Irak3 |
interleukin-1 receptor-associated kinase 3 |
increases expression multiple interactions |
ISO |
Imiquimod results in increased expression of IRAK3 mRNA ferulic acid inhibits the reaction [Imiquimod results in increased expression of IRAK3 mRNA] |
CTD |
PMID:31054998 |
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NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121
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Itgax |
integrin subunit alpha X |
multiple interactions |
ISO |
[imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ITGAX protein; Tetrachlorodibenzodioxin inhibits the reaction [[imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ITGAX protein] |
CTD |
PMID:21097750 |
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NCBI chr 1:182,709,653...182,740,709
Ensembl chr 1:182,719,609...182,740,698
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Kif22 |
kinesin family member 22 |
decreases expression |
ISO |
imiquimod results in decreased expression of KIF22 mRNA |
CTD |
PMID:21878529 |
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NCBI chr 1:181,635,347...181,650,351
Ensembl chr 1:181,635,183...181,650,401
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Lgmn |
legumain |
increases activity multiple interactions |
ISO |
Imiquimod results in increased activity of LGMN protein LGMN gene mutant form inhibits the reaction [Imiquimod results in increased cleavage of TLR7 protein]; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased expression of CD40 protein]; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased expression of CD86 protein]; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased secretion of IL12B protein]; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased secretion of IL6 protein] |
CTD |
PMID:22916010 |
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NCBI chr 6:121,544,048...121,582,495
Ensembl chr 6:121,544,053...121,582,480
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Lig1 |
DNA ligase 1 |
decreases expression |
ISO |
imiquimod results in decreased expression of LIG1 mRNA |
CTD |
PMID:21878529 |
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NCBI chr 1:74,165,688...74,204,400
Ensembl chr 1:74,165,842...74,204,413
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Lrch4 |
leucine rich repeats and calponin homology domain containing 4 |
multiple interactions |
ISO |
LRCH4 protein promotes the reaction [Imiquimod results in increased expression of TNF protein] |
CTD |
PMID:30523158 |
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NCBI chr12:19,057,582...19,072,573
Ensembl chr12:19,057,587...19,068,577
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G |
Mapk1 |
mitogen activated protein kinase 1 |
decreases phosphorylation |
ISO |
imiquimod results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:20033192 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
decreases phosphorylation |
ISO |
imiquimod results in decreased phosphorylation of MAPK3 protein |
CTD |
PMID:20033192 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mlh1 |
mutL homolog 1 |
decreases expression |
ISO |
imiquimod results in decreased expression of MLH1 mRNA |
CTD |
PMID:21878529 |
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NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617
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Mmp9 |
matrix metallopeptidase 9 |
decreases activity |
ISO |
imiquimod results in decreased activity of MMP9 protein |
CTD |
PMID:14708627 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Mpg |
N-methylpurine-DNA glycosylase |
decreases expression |
ISO |
imiquimod results in decreased expression of MPG mRNA |
CTD |
PMID:21878529 |
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NCBI chr10:15,396,246...15,402,528
Ensembl chr10:15,395,782...15,402,520
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Mpo |
myeloperoxidase |
increases activity multiple interactions |
ISO |
imiquimod results in increased activity of MPO protein (+)-JQ1 compound inhibits the reaction [imiquimod results in increased activity of MPO protein]; SR 1078 inhibits the reaction [(+)-JQ1 compound inhibits the reaction [imiquimod results in increased activity of MPO protein]] |
CTD |
PMID:26149470 |
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NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Mre11 |
MRE11 homolog, double strand break repair nuclease |
decreases expression |
ISO |
imiquimod results in decreased expression of MRE11A mRNA |
CTD |
PMID:21878529 |
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NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279
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Msh2 |
mutS homolog 2 |
decreases expression |
ISO |
imiquimod results in decreased expression of MSH2 mRNA |
CTD |
PMID:21878529 |
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NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938
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Nudt1 |
nudix hydrolase 1 |
decreases expression |
ISO |
imiquimod results in decreased expression of NUDT1 mRNA |
CTD |
PMID:21878529 |
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NCBI chr12:14,302,514...14,309,559
Ensembl chr12:14,302,694...14,305,826
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G |
Pck1 |
phosphoenolpyruvate carboxykinase 1 |
multiple interactions |
ISO |
[resveratrol co-treated with imiquimod] results in increased expression of PCK1 mRNA |
CTD |
PMID:25965695 |
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NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
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Pms2 |
PMS1 homolog 2, mismatch repair system component |
decreases expression |
ISO |
imiquimod results in decreased expression of PMS2 mRNA |
CTD |
PMID:21878529 |
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NCBI chr12:10,676,819...10,701,161
Ensembl chr12:10,676,764...10,701,066
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Pole |
DNA polymerase epsilon, catalytic subunit |
decreases expression |
ISO |
imiquimod results in decreased expression of POLE mRNA |
CTD |
PMID:21878529 |
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NCBI chr12:46,345,420...46,393,984
Ensembl chr12:46,345,420...46,393,939
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Poll |
DNA polymerase lambda |
decreases expression |
ISO |
imiquimod results in decreased expression of POLL mRNA |
CTD |
PMID:21878529 |
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NCBI chr 1:244,400,202...244,408,762
Ensembl chr 1:244,400,204...244,408,662
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Ppp1r3c |
protein phosphatase 1, regulatory subunit 3C |
multiple interactions |
ISO |
[resveratrol co-treated with imiquimod] results in decreased expression of PPP1R3C mRNA |
CTD |
PMID:25965695 |
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NCBI chr 1:234,460,958...234,465,961
Ensembl chr 1:234,460,652...234,465,961
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Rad51ap1 |
RAD51 associated protein 1 |
decreases expression |
ISO |
imiquimod results in decreased expression of RAD51AP1 mRNA |
CTD |
PMID:21878529 |
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NCBI chr 4:159,759,454...159,772,524
Ensembl chr 4:159,759,459...159,772,524
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Rad51d |
RAD51 paralog D |
decreases expression |
ISO |
imiquimod results in decreased expression of RAD51D mRNA |
CTD |
PMID:21878529 |
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NCBI chr10:67,805,720...67,824,452
Ensembl chr10:67,740,712...67,824,434
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Rad54l |
RAD54 like |
decreases expression |
ISO |
imiquimod results in decreased expression of RAD54L mRNA |
CTD |
PMID:21878529 |
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NCBI chr 5:129,575,431...129,605,100
Ensembl chr 5:129,575,378...129,605,070
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Rorc |
RAR-related orphan receptor C |
increases expression multiple interactions |
ISO |
imiquimod results in increased expression of RORC mRNA; imiquimod results in increased expression of RORC protein (+)-JQ1 compound inhibits the reaction [imiquimod results in increased expression of RORC mRNA]; (+)-JQ1 compound inhibits the reaction [imiquimod results in increased expression of RORC protein] |
CTD |
PMID:26149470 |
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NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907
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Ruvbl2 |
RuvB-like AAA ATPase 2 |
decreases expression |
ISO |
imiquimod results in decreased expression of RUVBL2 mRNA |
CTD |
PMID:21878529 |
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NCBI chr 1:95,902,014...95,915,364
Ensembl chr 1:95,901,701...95,915,342
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Slc47a1 |
solute carrier family 47 member 1 |
multiple interactions |
ISO |
imiquimod inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:22419765 |
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NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
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G |
Slc47a2 |
solute carrier family 47 member 2 |
multiple interactions |
ISO |
imiquimod inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:22419765 |
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NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
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Ssrp1 |
structure specific recognition protein 1 |
decreases expression |
ISO |
imiquimod results in decreased expression of SSRP1 mRNA |
CTD |
PMID:21878529 |
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NCBI chr 3:70,124,371...70,134,481
Ensembl chr 3:70,118,655...70,134,482
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Stat3 |
signal transducer and activator of transcription 3 |
increases expression |
ISO |
imiquimod results in increased expression of STAT3 mRNA |
CTD |
PMID:26149470 |
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NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Tgfb1 |
transforming growth factor, beta 1 |
increases secretion |
ISO |
Imiquimod results in increased secretion of TGFB1 protein |
CTD |
PMID:34740670 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
increases expression |
ISO |
imiquimod results in increased expression of TIMP1 protein |
CTD |
PMID:14708627 |
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NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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G |
Tlr7 |
toll-like receptor 7 |
multiple interactions increases cleavage affects binding |
ISO |
[Imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]; [Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of CD86 protein; [Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ICAM1 protein; [Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ITGAX protein; [Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased secretion of IL6 protein; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased cleavage of TLR7 protein]; Tetrachlorodibenzodioxin inhibits the reaction [[Imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]]; Tetrachlorodibenzodioxin inhibits the reaction [[Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ITGAX protein]; Tetrachlorodibenzodioxin promotes the reaction [[Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of CD86 protein]; Tetrachlorodibenzodioxin promotes the reaction [[Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ICAM1 protein] Imiquimod binds to TLR7 protein |
CTD |
PMID:21097750 PMID:22916010 PMID:31093508 |
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NCBI chr X:27,027,380...27,054,309
Ensembl chr X:27,027,425...27,054,754
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Tnf |
tumor necrosis factor |
multiple interactions increases secretion increases expression |
ISO |
CGP 57380 inhibits the reaction [Imiquimod results in increased expression of TNF protein]; LRCH4 protein promotes the reaction [Imiquimod results in increased expression of TNF protein] Cannabidiol promotes the reaction [Imiquimod results in increased secretion of TNF protein] Imiquimod results in increased expression of TNF mRNA; Imiquimod results in increased expression of TNF protein |
CTD |
PMID:18032482 PMID:25965695 PMID:26149470 PMID:30523158 PMID:31093508 PMID:34740670 More...
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Trex1 |
three prime repair exonuclease 1 |
increases expression |
ISO |
imiquimod results in increased expression of TREX1 mRNA |
CTD |
PMID:21878529 |
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NCBI chr 8:109,706,613...109,707,913
Ensembl chr 8:109,706,613...109,708,796
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G |
Trim63 |
tripartite motif containing 63 |
multiple interactions |
ISO |
[resveratrol co-treated with imiquimod] results in increased expression of TRIM63 mRNA |
CTD |
PMID:25965695 |
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NCBI chr 5:146,533,492...146,547,332
Ensembl chr 5:146,533,507...146,547,322
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G |
Uhrf1 |
ubiquitin-like with PHD and ring finger domains 1 |
decreases expression |
ISO |
imiquimod results in decreased expression of UHRF1 mRNA |
CTD |
PMID:21878529 |
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NCBI chr 9:1,133,117...1,154,639
Ensembl chr 9:1,134,909...1,154,631
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G |
Wrnip1 |
WRN helicase interacting protein 1 |
decreases expression |
ISO |
imiquimod results in decreased expression of WRNIP1 mRNA |
CTD |
PMID:21878529 |
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NCBI chr17:31,621,410...31,641,659
Ensembl chr17:31,621,411...31,641,659
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G |
Xpc |
XPC complex subunit, DNA damage recognition and repair factor |
increases expression |
ISO |
imiquimod results in increased expression of XPC mRNA |
CTD |
PMID:21878529 |
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NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010
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