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ONTOLOGY REPORT - ANNOTATIONS
Term:imiquimod
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Accession:CHEBI:36704 term browser browse the term
Definition:An imidazoquinoline fused [4,5-c] carrying isobutyl and amino substituents at N-1 and C-4 respectively. A prescription medication, it acts as an immune response modifier and is used to treat genital warts, superficial basal cell carcinoma, and actinic keratosis.
Synonyms:exact_synonym: 1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine
 related_synonym: 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine;   4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline;   Formula=C14H16N4;   InChI=1S/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17);   InChIKey=DOUYETYNHWVLEO-UHFFFAOYSA-N;   R 837;   SMILES=C1=2C=CC=CC2N=C(C=3N=CN(C13)CC(C)C)N;   imiquimodum
 xref: Beilstein:7710060 "Beilstein";   CAS:99011-02-6 "ChemIDplus";   DrugBank:DB00724;   Drug_Central:1429 "DrugCentral";   LINCS:LSM-5408
 xref_mesh: MESH:C056493
 xref: PMID:10861101 "Europe PMC";   PMID:15868314 "Europe PMC";   PMID:16217984 "Europe PMC";   PMID:18424373 "Europe PMC";   PMID:27548435 "Europe PMC";   PMID:28872561 "Europe PMC";   PMID:29422777 "Europe PMC";   PMID:29485187 "Europe PMC";   PMID:29505317 "Europe PMC";   PMID:29596875 "Europe PMC";   Patent:AU2005320890;   Patent:EP1831219;   Patent:KR20070102652;   Reaxys:7710060 "Reaxys";   Wikipedia:Imiquimod

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imiquimod term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 JBrowse link 15 27,849,943 27,852,083 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Blm BLM RecQ like helicase JBrowse link 1 142,246,773 142,332,616 RGD:6480464
G Brca2 BRCA2, DNA repair associated JBrowse link 12 503,660 544,754 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Cd86 CD86 molecule JBrowse link 11 67,060,305 67,117,990 RGD:6480464
G Chaf1a chromatin assembly factor 1 subunit A JBrowse link 9 11,000,869 11,027,631 RGD:6480464
G Chaf1b chromatin assembly factor 1 subunit B JBrowse link 11 34,101,248 34,121,371 RGD:6480464
G Cxcl10 C-X-C motif chemokine ligand 10 JBrowse link 14 17,210,733 17,212,930 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 JBrowse link 1 147,713,879 147,814,410 RGD:6480464
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 JBrowse link 7 123,599,264 123,608,436 RGD:6480464
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit JBrowse link 1 80,293,574 80,307,334 RGD:6480464
G Ercc5 ERCC excision repair 5, endonuclease JBrowse link 9 50,928,847 50,970,962 RGD:6480464
G Fancl FA complementation group L JBrowse link 14 110,675,306 110,740,880 RGD:6480464
G Fbh1 F-box DNA helicase 1 JBrowse link 17 70,399,093 70,437,151 RGD:6480464
G Fgf2 fibroblast growth factor 2 JBrowse link 2 124,081,072 124,134,133 RGD:6480464
G Gtf2h3 general transcription factor IIH subunit 3 JBrowse link 12 37,427,556 37,444,027 RGD:6480464
G Gtf2h4 general transcription factor 2H subunit 4 JBrowse link 20 3,582,688 3,588,373 RGD:6480464
G Icam1 intercellular adhesion molecule 1 JBrowse link 8 22,035,287 22,047,049 RGD:6480464
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6480464
G Il11 interleukin 11 JBrowse link 1 72,636,959 72,643,255 RGD:6480464
G Il11ra1 interleukin 11 receptor subunit alpha 1 JBrowse link 5 58,149,150 58,159,072 RGD:6480464
G Il12a interleukin 12A JBrowse link 2 165,076,945 165,083,996 RGD:6480464
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:6480464
G Il13ra1 interleukin 13 receptor subunit alpha 1 JBrowse link X 122,724,081 122,783,801 RGD:6480464
G Il13ra2 interleukin 13 receptor subunit alpha 2 JBrowse link X 118,443,955 118,514,716 RGD:6480464
G Il17a interleukin 17A JBrowse link 9 26,841,299 26,844,786 RGD:6480464
G Il17b interleukin 17B JBrowse link 18 57,011,575 57,016,009 RGD:6480464
G Il17rb interleukin 17 receptor B JBrowse link 16 6,064,287 6,077,978 RGD:6480464
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:6480464
G Il18rap interleukin 18 receptor accessory protein JBrowse link 9 47,225,543 47,255,805 RGD:6480464
G Il19 interleukin 19 JBrowse link 13 47,663,592 47,677,869 RGD:6480464
G Il1a interleukin 1 alpha JBrowse link 3 121,824,712 121,836,122 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il1f10 interleukin 1 family member 10 JBrowse link 3 1,408,560 1,416,601 RGD:6480464
G Il1rap interleukin 1 receptor accessory protein JBrowse link 11 77,456,648 77,593,208 RGD:6480464
G Il20 interleukin 20 JBrowse link 13 47,644,071 47,651,487 RGD:6480464
G Il20rb interleukin 20 receptor subunit beta JBrowse link 8 108,745,906 108,778,561 RGD:6480464
G Il22 interleukin 22 JBrowse link 7 61,236,037 61,240,502 RGD:6480464
G Il22ra1 interleukin 22 receptor subunit alpha 1 JBrowse link 5 154,078,093 154,102,903 RGD:6480464
G Il23a interleukin 23 subunit alpha JBrowse link 7 2,710,609 2,712,723 RGD:6480464
G Il27 interleukin 27 JBrowse link 1 198,003,615 198,010,112 RGD:6480464
G Il33 interleukin 33 JBrowse link 1 248,112,611 248,147,030 RGD:6480464
G Il36a interleukin 36, alpha JBrowse link 3 1,330,790 1,335,811 RGD:6480464
G Il36b interleukin 36, beta JBrowse link 3 1,366,123 1,464,851 RGD:6480464
G Il36g interleukin 36, gamma JBrowse link 3 1,285,658 1,291,836 RGD:6480464
G Il36rn interleukin 36 receptor antagonist JBrowse link 3 1,385,256 1,392,275 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Il7 interleukin 7 JBrowse link 2 96,427,884 96,474,979 RGD:6480464
G Il7r interleukin 7 receptor RGD:6480464
G Il9r interleukin 9 receptor JBrowse link 10 15,697,216 15,708,684 RGD:6480464
G Irak2 interleukin-1 receptor-associated kinase 2 JBrowse link 4 145,594,575 145,651,066 RGD:6480464
G Irak3 interleukin-1 receptor-associated kinase 3 JBrowse link 7 64,922,830 64,982,224 RGD:6480464
G Itgax integrin subunit alpha X JBrowse link 1 199,555,560 199,576,948 RGD:6480464
G Kif22 kinesin family member 22 JBrowse link 1 198,461,406 198,476,430 RGD:6480464
G Lig1 DNA ligase 1 JBrowse link 1 75,356,212 75,394,757 RGD:6480464
G Lrch4 leucine rich repeats and calponin homology domain containing 4 JBrowse link 12 22,127,387 22,138,436 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mlh1 mutL homolog 1 JBrowse link 8 119,486,655 119,523,716 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:6480464
G Mpg N-methylpurine-DNA glycosylase JBrowse link 10 15,661,768 15,667,995 RGD:6480464
G Mpo myeloperoxidase JBrowse link 10 75,087,892 75,098,260 RGD:6480464
G Mre11 MRE11 homolog, double strand break repair nuclease JBrowse link 8 13,304,355 13,350,329 RGD:6480464
G Msh2 mutS homolog 2 JBrowse link 6 11,215,951 11,274,916 RGD:6480464
G Nudt1 nudix hydrolase 1 JBrowse link 12 16,391,578 16,398,771 RGD:6480464
G Pck1 phosphoenolpyruvate carboxykinase 1 JBrowse link 3 171,213,936 171,219,885 RGD:6480464
G Pms2 PMS1 homolog 2, mismatch repair system component JBrowse link 12 12,714,394 12,738,654 RGD:6480464
G Pole DNA polymerase epsilon, catalytic subunit JBrowse link 12 52,403,533 52,452,075 RGD:6480464
G Poll DNA polymerase lambda JBrowse link 1 265,290,337 265,298,847 RGD:6480464
G Ppp1r3c protein phosphatase 1, regulatory subunit 3C JBrowse link 1 255,371,830 255,376,833 RGD:6480464
G Rad51ap1 RAD51 associated protein 1 JBrowse link 4 159,469,803 159,482,869 RGD:6480464
G Rad51d RAD51 paralog D JBrowse link 10 70,222,703 70,241,352 RGD:6480464
G Rad54l RAD54 like JBrowse link 5 134,948,511 134,978,125 RGD:6480464
G Rorc RAR-related orphan receptor C JBrowse link 2 195,612,471 195,636,797 RGD:6480464
G Ruvbl2 RuvB-like AAA ATPase 2 JBrowse link 1 101,413,766 101,426,970 RGD:6480464
G Slc47a1 solute carrier family 47 member 1 JBrowse link 10 47,631,425 47,685,379 RGD:6480464
G Slc47a2 solute carrier family 47 member 2 JBrowse link 10 47,587,909 47,631,373 RGD:6480464
G Ssrp1 structure specific recognition protein 1 JBrowse link 3 72,447,516 72,457,621 RGD:6480464
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:6480464
G Timp1 TIMP metallopeptidase inhibitor 1 JBrowse link X 1,364,771 1,369,451 RGD:6480464
G Tlr7 toll-like receptor 7 JBrowse link X 28,486,836 28,513,004 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Trex1 three prime repair exonuclease 1 JBrowse link 8 117,796,127 117,797,427 RGD:6480464
G Trim63 tripartite motif containing 63 JBrowse link 5 152,533,362 152,547,138 RGD:6480464
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 JBrowse link 9 10,738,211 10,758,403 RGD:6480464
G Wrnip1 WRN helicase interacting protein 1 JBrowse link 17 32,933,395 32,953,641 RGD:6480464
G Xpc XPC complex subunit, DNA damage recognition and repair factor JBrowse link 4 123,134,457 123,161,985 RGD:6480464
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      application 19235
        pharmaceutical 19097
          drug 19097
            antineoplastic agent 16555
              imiquimod 91
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic molecule 19343
                              organic cyclic compound 19093
                                organic heterocyclic compound 18157
                                  organic heteropolycyclic compound 17423
                                    organic heterotricyclic compound 13723
                                      imidazoquinoline 151
                                        imiquimod 91
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