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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:imiquimod
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Accession:CHEBI:36704 term browser browse the term
Definition:An imidazoquinoline fused [4,5-c] carrying isobutyl and amino substituents at N-1 and C-4 respectively. A prescription medication, it acts as an immune response modifier and is used to treat genital warts, superficial basal cell carcinoma, and actinic keratosis.
Synonyms:exact_synonym: 1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine
 related_synonym: 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine;   4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline;   Formula=C14H16N4;   InChI=1S/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17);   InChIKey=DOUYETYNHWVLEO-UHFFFAOYSA-N;   R 837;   SMILES=C1=2C=CC=CC2N=C(C=3N=CN(C13)CC(C)C)N;   imiquimodum
 xref: Beilstein:7710060;   CAS:99011-02-6;   DrugBank:DB00724;   Drug_Central:1429;   LINCS:LSM-5408
 xref_mesh: MESH:C056493
 xref: PMID:10861101;   PMID:15868314;   PMID:16217984;   PMID:18424373;   PMID:27548435;   PMID:28872561;   PMID:29422777;   PMID:29485187;   PMID:29505317;   PMID:29596875;   Patent:AU2005320890;   Patent:EP1831219;   Patent:KR20070102652;   Reaxys:7710060;   Wikipedia:Imiquimod


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imiquimod term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation		 ISO epigallocatechin gallate inhibits the reaction [Imiquimod results in increased phosphorylation of AKT1 protein] CTD PMID:24990399 PMID:29402411 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 decreases expression ISO imiquimod results in decreased expression of APEX1 mRNA CTD PMID:21878529 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO imiquimod results in decreased expression of BCL2 protein CTD PMID:20033192 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Blm BLM RecQ like helicase decreases expression ISO imiquimod results in decreased expression of BLM mRNA CTD PMID:21878529 NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312 		JBrowse link
G Brca2 BRCA2, DNA repair associated decreases expression ISO imiquimod results in decreased expression of BRCA2 mRNA CTD PMID:21878529 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567 		JBrowse link
G Bst2 bone marrow stromal cell antigen 2 increases expression ISO Imiquimod results in increased expression of BST2 protein CTD PMID:31093508 NCBI chr16:18,217,404...18,220,979
Ensembl chr16:18,217,407...18,220,979 		JBrowse link
G Casp1 caspase 1 increases activity
multiple interactions		 ISO Imiquimod results in increased activity of CASP1 protein
[Dronabinol inhibits the reaction [Imiquimod results in increased activity of CASP1 protein]] which affects the localization of IL1B protein; Dronabinol inhibits the reaction [Imiquimod results in increased activity of CASP1 protein]		 CTD PMID:31383729 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage		 ISO imiquimod results in increased activity of CASP3 protein
imiquimod results in increased cleavage of CASP3 protein		 CTD PMID:12902443 PMID:20033192 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases secretion ISO Imiquimod results in increased secretion of CCL2 protein CTD PMID:34740670 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cd274 CD274 molecule increases expression ISO Imiquimod results in increased expression of CD274 protein CTD PMID:31093508 NCBI chr 1:227,116,627...227,137,379
Ensembl chr 1:227,116,649...227,134,450 		JBrowse link
G Cd40 CD40 molecule increases expression
multiple interactions		 ISO Imiquimod results in increased expression of CD40 protein
LGMN gene mutant form inhibits the reaction [Imiquimod results in increased expression of CD40 protein]		 CTD PMID:22916010 PMID:31093508 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cd80 Cd80 molecule increases expression ISO Imiquimod results in increased expression of CD80 protein CTD PMID:31093508 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030 		JBrowse link
G Cd86 CD86 molecule multiple interactions
increases expression		 ISO [Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of CD86 protein; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased expression of CD86 protein]; Tetrachlorodibenzodioxin promotes the reaction [[Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of CD86 protein] CTD PMID:21097750 PMID:22916010 PMID:31093508 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Chaf1a chromatin assembly factor 1 subunit A decreases expression ISO imiquimod results in decreased expression of CHAF1A mRNA CTD PMID:21878529 NCBI chr 9:873,953...900,701
Ensembl chr 9:874,051...900,654 		JBrowse link
G Chaf1b chromatin assembly factor 1 subunit B decreases expression ISO imiquimod results in decreased expression of CHAF1B mRNA CTD PMID:21878529 NCBI chr11:33,200,894...33,221,076
Ensembl chr11:33,200,981...33,221,070 		JBrowse link
G Ctsb cathepsin B increases activity ISO Imiquimod results in increased activity of CTSB protein CTD PMID:22916010 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Ctsk cathepsin K increases activity ISO Imiquimod results in increased activity of CTSK protein CTD PMID:22916010 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550 		JBrowse link
G Ctsl cathepsin L increases activity ISO Imiquimod results in increased activity of CTSL protein CTD PMID:22916010 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548 		JBrowse link
G Ctss cathepsin S increases activity ISO Imiquimod results in increased activity of CTSS protein CTD PMID:22916010 NCBI chr 2:183,089,192...183,114,483
Ensembl chr 2:183,086,437...183,114,483 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO [Pam(3)CSK(4) peptide co-treated with Antigens, Bacterial co-treated with Poly I-C co-treated with Lipopolysaccharides co-treated with FSL-1 lipoprotein, synthetic co-treated with imiquimod co-treated with Polyribonucleotides co-treated with ProMune] results in increased expression of CXCL10 protein; Particulate Matter inhibits the reaction [[Pam(3)CSK(4) peptide co-treated with Antigens, Bacterial co-treated with Poly I-C co-treated with Lipopolysaccharides co-treated with FSL-1 lipoprotein, synthetic co-treated with imiquimod co-treated with Polyribonucleotides co-treated with ProMune] results in increased expression of CXCL10 protein]; Vehicle Emissions inhibits the reaction [[Pam(3)CSK(4) peptide co-treated with Antigens, Bacterial co-treated with Poly I-C co-treated with Lipopolysaccharides co-treated with FSL-1 lipoprotein, synthetic co-treated with imiquimod co-treated with Polyribonucleotides co-treated with ProMune] results in increased expression of CXCL10 protein] CTD PMID:28655636 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases secretion ISO Imiquimod results in increased secretion of CXCL1 protein CTD PMID:22916010 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing
multiple interactions
affects metabolic processing
increases chemical synthesis		 ISO CYP1A1 protein results in increased metabolism of Imiquimod
CYP1A1 protein affects the reaction [beta-Naphthoflavone results in increased metabolism of Imiquimod]
CYP1A1 protein affects the metabolism of Imiquimod
[CYP1A1 protein results in increased metabolism of Imiquimod] which results in increased chemical synthesis of Imiquimod metabolite
CYP1A1 protein results in increased chemical synthesis of Imiquimod metabolite		 CTD PMID:31111189 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
affects metabolic processing
increases chemical synthesis
increases metabolic processing		 ISO [CYP1A2 protein results in increased metabolism of Imiquimod] which results in increased chemical synthesis of Imiquimod metabolite
CYP1A2 protein affects the metabolism of Imiquimod
CYP1A2 protein results in increased chemical synthesis of Imiquimod metabolite
CYP1A2 protein affects the reaction [beta-Naphthoflavone results in increased metabolism of Imiquimod]		 CTD PMID:31111189 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases metabolic processing ISO CYP2C19 protein results in increased metabolism of Imiquimod CTD PMID:31111189 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing ISO CYP2D6 protein results in increased metabolism of Imiquimod CTD PMID:31111189 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit decreases expression ISO imiquimod results in decreased expression of ERCC2 mRNA CTD PMID:21878529 NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102 		JBrowse link
G Ercc5 ERCC excision repair 5, endonuclease increases expression ISO imiquimod results in increased expression of ERCC5 mRNA CTD PMID:21878529 NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472 		JBrowse link
G Fancl FA complementation group L decreases expression ISO imiquimod results in decreased expression of FANCL mRNA CTD PMID:21878529 NCBI chr14:100,249,733...100,317,958
Ensembl chr14:100,248,875...100,314,255 		JBrowse link
G Fbh1 F-box DNA helicase 1 decreases expression ISO imiquimod results in decreased expression of FBH1 mRNA CTD PMID:21878529 NCBI chr17:66,749,506...66,787,590
Ensembl chr17:66,749,534...66,787,590 		JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression ISO imiquimod results in decreased expression of FGF2 CTD PMID:16368197 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Gtf2h3 general transcription factor IIH subunit 3 decreases expression ISO imiquimod results in decreased expression of GTF2H3 mRNA CTD PMID:21878529 NCBI chr12:32,009,010...32,025,484
Ensembl chr12:32,009,014...32,025,497 		JBrowse link
G Gtf2h4 general transcription factor 2H subunit 4 decreases expression ISO imiquimod results in decreased expression of GTF2H4 mRNA CTD PMID:21878529 NCBI chr20:3,071,328...3,076,990
Ensembl chr20:3,071,328...3,076,984 		JBrowse link
G Gzmb granzyme B multiple interactions ISO Imiquimod results in increased expression of and results in increased secretion of GZMB protein CTD PMID:31093508 NCBI chr15:30,343,361...30,346,792
Ensembl chr15:30,173,603...30,346,814 		JBrowse link
G H2ax H2A.X variant histone decreases expression ISO Imiquimod results in decreased expression of H2AX mRNA CTD PMID:21878529 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO [imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ICAM1 protein; Tetrachlorodibenzodioxin promotes the reaction [[imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ICAM1 protein] CTD PMID:21097750 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Hydroxychloroquine co-treated with Imiquimod] results in increased secretion of IL10 protein CTD PMID:31082466 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il11 interleukin 11 multiple interactions
decreases expression		 ISO ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL11 mRNA] CTD PMID:31054998 NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129 		JBrowse link
G Il11ra1 interleukin 11 receptor subunit alpha 1 multiple interactions
decreases expression		 ISO ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL11RA1 mRNA] CTD PMID:31054998 NCBI chr 5:56,931,824...56,941,408
Ensembl chr 5:56,935,516...56,941,408 		JBrowse link
G Il12a interleukin 12A multiple interactions
increases secretion		 ISO [imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]; Tetrachlorodibenzodioxin inhibits the reaction [[imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]]
Imiquimod results in increased secretion of IL12A protein		 CTD PMID:21097750 PMID:31093508 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B multiple interactions
increases secretion
increases expression		 ISO [Imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]; ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL12B mRNA]; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased secretion of IL12B protein]; Tetrachlorodibenzodioxin inhibits the reaction [[Imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]] CTD PMID:21097750 PMID:22916010 PMID:31054998 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 multiple interactions
increases expression		 ISO ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL13RA1 mRNA] CTD PMID:31054998 NCBI chr  X:115,348,860...115,408,682
Ensembl chr  X:115,348,860...115,408,681 		JBrowse link
G Il13ra2 interleukin 13 receptor subunit alpha 2 increases expression ISO Imiquimod results in increased expression of IL13RA2 mRNA CTD PMID:31054998 NCBI chr  X:111,002,590...111,074,053
Ensembl chr  X:111,002,592...111,072,381 		JBrowse link
G Il17a interleukin 17A multiple interactions
increases expression
increases secretion		 ISO (+)-JQ1 compound inhibits the reaction [Imiquimod results in increased expression of IL17A mRNA]; (+)-JQ1 compound inhibits the reaction [Imiquimod results in increased secretion of IL17A protein]; ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL17A mRNA]; ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL17A protein]; Resveratrol inhibits the reaction [Imiquimod results in increased expression of IL17A mRNA]; SR 1078 inhibits the reaction [(+)-JQ1 compound inhibits the reaction [Imiquimod results in increased expression of IL17A mRNA]]; SR 1078 inhibits the reaction [(+)-JQ1 compound inhibits the reaction [Imiquimod results in increased secretion of IL17A protein]]
Imiquimod results in increased expression of IL17A mRNA; Imiquimod results in increased expression of IL17A protein
imiquimod results in increased secretion of IL17A protein		 CTD PMID:25965695 PMID:26149470 PMID:31054998 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il17b interleukin 17B decreases expression
multiple interactions		 ISO Imiquimod results in decreased expression of IL17B mRNA
ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL17B mRNA]		 CTD PMID:31054998 NCBI chr18:55,141,194...55,145,565
Ensembl chr18:55,141,194...55,145,565 		JBrowse link
G Il17rb interleukin 17 receptor B decreases expression
multiple interactions		 ISO Imiquimod results in decreased expression of IL17RB mRNA
ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL17RB mRNA]		 CTD PMID:31054998 NCBI chr16:5,180,431...5,194,125
Ensembl chr16:5,180,432...5,194,125 		JBrowse link
G Il18 interleukin 18 increases expression
multiple interactions		 ISO Imiquimod results in increased expression of IL18 mRNA
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL18 mRNA]		 CTD PMID:31054998 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il18rap interleukin 18 receptor accessory protein multiple interactions
increases expression		 ISO ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL18RAP mRNA] CTD PMID:31054998 NCBI chr 9:42,768,112...42,800,964
Ensembl chr 9:42,768,220...42,800,959 		JBrowse link
G Il19 interleukin 19 increases expression
multiple interactions		 ISO imiquimod results in increased expression of IL19 mRNA
resveratrol inhibits the reaction [imiquimod results in increased expression of IL19 mRNA]		 CTD PMID:25965695 NCBI chr13:42,397,715...42,411,637
Ensembl chr13:42,399,138...42,405,473 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions
increases expression		 ISO ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL1A mRNA] CTD PMID:31054998 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta increases secretion
multiple interactions
increases expression		 ISO Imiquimod results in increased secretion of IL1B protein
[Dronabinol inhibits the reaction [Imiquimod results in increased activity of CASP1 protein]] which affects the localization of IL1B protein; Cannabidiol inhibits the reaction [Imiquimod results in increased secretion of IL1B protein]; Dronabinol inhibits the reaction [Imiquimod results in increased expression of IL1B mRNA]; Dronabinol inhibits the reaction [Imiquimod results in increased secretion of IL1B protein]; JHW 015 inhibits the reaction [Imiquimod results in increased secretion of IL1B protein]
Imiquimod results in increased expression of IL1B mRNA; Imiquimod results in increased expression of IL1B protein
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL1B mRNA]; ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL1B protein]		 CTD PMID:18403674 PMID:31054998 PMID:31082466 PMID:31383729 PMID:34740670 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1f10 interleukin 1 family member 10 decreases expression
multiple interactions		 ISO Imiquimod results in decreased expression of IL1F10 mRNA
ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL1F10 mRNA]		 CTD PMID:31054998 NCBI chr 3:7,072,511...7,075,439
Ensembl chr 3:7,072,511...7,075,439 		JBrowse link
G Il1rap interleukin 1 receptor accessory protein increases expression ISO Imiquimod results in increased expression of IL1RAP mRNA CTD PMID:31054998 NCBI chr11:74,062,999...74,199,530
Ensembl chr11:74,070,304...74,199,530 		JBrowse link
G Il2 interleukin 2 increases secretion ISO Imiquimod results in increased secretion of IL2 protein CTD PMID:34740670 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il20 interleukin 20 increases expression
multiple interactions		 ISO Imiquimod results in increased expression of IL20 mRNA
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL20 mRNA]		 CTD PMID:31054998 NCBI chr13:42,380,981...42,384,625
Ensembl chr13:42,380,981...42,384,625 		JBrowse link
G Il20rb interleukin 20 receptor subunit beta increases expression
multiple interactions		 ISO Imiquimod results in increased expression of IL20RB mRNA
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL20RB mRNA]		 CTD PMID:31054998 NCBI chr 8:100,979,085...101,010,829
Ensembl chr 8:100,980,383...101,009,942 		JBrowse link
G Il22ra1 interleukin 22 receptor subunit alpha 1 increases expression
multiple interactions		 ISO Imiquimod results in increased expression of IL22RA1 mRNA
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL22RA1 mRNA]		 CTD PMID:31054998 NCBI chr 5:147,961,496...147,986,296
Ensembl chr 5:147,961,349...147,986,296 		JBrowse link
G Il23a interleukin 23 subunit alpha increases secretion
multiple interactions
increases expression		 ISO imiquimod results in increased secretion of IL23A protein
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL23A mRNA]; ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL23A protein]
Imiquimod results in increased expression of IL23A mRNA; Imiquimod results in increased expression of IL23A protein		 CTD PMID:25965695 PMID:26149470 PMID:31054998 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923 		JBrowse link
G Il27 interleukin 27 multiple interactions
increases expression		 ISO ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL27 mRNA] CTD PMID:31054998 NCBI chr 1:181,173,108...181,178,720
Ensembl chr 1:181,173,372...181,178,582 		JBrowse link
G Il33 interleukin 33 multiple interactions
increases expression		 ISO ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL33 mRNA] CTD PMID:31054998 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373 		JBrowse link
G Il36a interleukin 36, alpha increases expression
multiple interactions		 ISO Imiquimod results in increased expression of IL36A mRNA
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL36A mRNA]		 CTD PMID:31054998 NCBI chr 3:6,996,851...7,001,400
Ensembl chr 3:6,996,851...7,001,400 		JBrowse link
G Il36b interleukin 36, beta increases expression
multiple interactions		 ISO Imiquimod results in increased expression of IL36B mRNA
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL36B mRNA]		 CTD PMID:31054998 NCBI chr 3:7,024,862...7,122,489
Ensembl chr 3:7,021,973...7,031,619 		JBrowse link
G Il36g interleukin 36, gamma multiple interactions
increases expression		 ISO ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL36G mRNA] CTD PMID:31054998 NCBI chr 3:6,948,323...6,954,485
Ensembl chr 3:6,948,297...6,954,480 		JBrowse link
G Il36rn interleukin 36 receptor antagonist multiple interactions
increases expression		 ISO ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL36RN mRNA] CTD PMID:31054998 NCBI chr 3:7,044,419...7,051,016
Ensembl chr 3:7,044,406...7,051,016 		JBrowse link
G Il4 interleukin 4 increases secretion ISO Imiquimod results in increased secretion of IL4 protein CTD PMID:34740670 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases secretion		 ISO [Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased secretion of IL6 protein; concanamycin B inhibits the reaction [Imiquimod results in increased secretion of IL6 protein]; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased secretion of IL6 protein]; MV026630 inhibits the reaction [Imiquimod results in increased secretion of IL6 protein]
[Hydroxychloroquine co-treated with Imiquimod] results in increased secretion of IL6 protein; Cannabidiol promotes the reaction [Imiquimod results in increased secretion of IL6 protein]		 CTD PMID:21097750 PMID:22916010 PMID:31082466 PMID:31093508 PMID:31383729 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Il7 interleukin 7 increases expression
multiple interactions		 ISO Imiquimod results in increased expression of IL7 mRNA
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL7 mRNA]		 CTD PMID:31054998 NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075 		JBrowse link
G Il7r interleukin 7 receptor multiple interactions
increases expression		 ISO ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL7R mRNA] CTD PMID:31054998 NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757 		JBrowse link
G Il9r interleukin 9 receptor decreases expression
multiple interactions		 ISO Imiquimod results in decreased expression of IL9R mRNA
ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL9R mRNA]		 CTD PMID:31054998 NCBI chr10:15,431,706...15,444,144
Ensembl chr10:15,431,706...15,441,990 		JBrowse link
G Irak2 interleukin-1 receptor-associated kinase 2 multiple interactions
increases expression		 ISO ferulic acid inhibits the reaction [Imiquimod results in increased expression of IRAK2 mRNA] CTD PMID:31054998 NCBI chr 4:146,786,004...146,842,615
Ensembl chr 4:146,786,100...146,842,602 		JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 increases expression
multiple interactions		 ISO Imiquimod results in increased expression of IRAK3 mRNA
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IRAK3 mRNA]		 CTD PMID:31054998 NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121 		JBrowse link
G Itgax integrin subunit alpha X multiple interactions ISO [imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ITGAX protein; Tetrachlorodibenzodioxin inhibits the reaction [[imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ITGAX protein] CTD PMID:21097750 NCBI chr 1:182,709,653...182,740,709
Ensembl chr 1:182,719,609...182,740,698 		JBrowse link
G Kif22 kinesin family member 22 decreases expression ISO imiquimod results in decreased expression of KIF22 mRNA CTD PMID:21878529 NCBI chr 1:181,635,347...181,650,351
Ensembl chr 1:181,635,183...181,650,401 		JBrowse link
G Lgmn legumain increases activity
multiple interactions		 ISO Imiquimod results in increased activity of LGMN protein
LGMN gene mutant form inhibits the reaction [Imiquimod results in increased cleavage of TLR7 protein]; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased expression of CD40 protein]; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased expression of CD86 protein]; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased secretion of IL12B protein]; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased secretion of IL6 protein]		 CTD PMID:22916010 NCBI chr 6:121,544,048...121,582,495
Ensembl chr 6:121,544,053...121,582,480 		JBrowse link
G Lig1 DNA ligase 1 decreases expression ISO imiquimod results in decreased expression of LIG1 mRNA CTD PMID:21878529 NCBI chr 1:74,165,688...74,204,400
Ensembl chr 1:74,165,842...74,204,413 		JBrowse link
G Lrch4 leucine rich repeats and calponin homology domain containing 4 multiple interactions ISO LRCH4 protein promotes the reaction [Imiquimod results in increased expression of TNF protein] CTD PMID:30523158 NCBI chr12:19,057,582...19,072,573
Ensembl chr12:19,057,587...19,068,577 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO imiquimod results in decreased phosphorylation of MAPK1 protein CTD PMID:20033192 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO imiquimod results in decreased phosphorylation of MAPK3 protein CTD PMID:20033192 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mlh1 mutL homolog 1 decreases expression ISO imiquimod results in decreased expression of MLH1 mRNA CTD PMID:21878529 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases activity ISO imiquimod results in decreased activity of MMP9 protein CTD PMID:14708627 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpg N-methylpurine-DNA glycosylase decreases expression ISO imiquimod results in decreased expression of MPG mRNA CTD PMID:21878529 NCBI chr10:15,396,246...15,402,528
Ensembl chr10:15,395,782...15,402,520 		JBrowse link
G Mpo myeloperoxidase increases activity
multiple interactions		 ISO imiquimod results in increased activity of MPO protein
(+)-JQ1 compound inhibits the reaction [imiquimod results in increased activity of MPO protein]; SR 1078 inhibits the reaction [(+)-JQ1 compound inhibits the reaction [imiquimod results in increased activity of MPO protein]]		 CTD PMID:26149470 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease decreases expression ISO imiquimod results in decreased expression of MRE11A mRNA CTD PMID:21878529 NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279 		JBrowse link
G Msh2 mutS homolog 2 decreases expression ISO imiquimod results in decreased expression of MSH2 mRNA CTD PMID:21878529 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Nudt1 nudix hydrolase 1 decreases expression ISO imiquimod results in decreased expression of NUDT1 mRNA CTD PMID:21878529 NCBI chr12:14,302,514...14,309,559
Ensembl chr12:14,302,694...14,305,826 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions ISO [resveratrol co-treated with imiquimod] results in increased expression of PCK1 mRNA CTD PMID:25965695 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component decreases expression ISO imiquimod results in decreased expression of PMS2 mRNA CTD PMID:21878529 NCBI chr12:10,676,819...10,701,161
Ensembl chr12:10,676,764...10,701,066 		JBrowse link
G Pole DNA polymerase epsilon, catalytic subunit decreases expression ISO imiquimod results in decreased expression of POLE mRNA CTD PMID:21878529 NCBI chr12:46,345,420...46,393,984
Ensembl chr12:46,345,420...46,393,939 		JBrowse link
G Poll DNA polymerase lambda decreases expression ISO imiquimod results in decreased expression of POLL mRNA CTD PMID:21878529 NCBI chr 1:244,400,202...244,408,762
Ensembl chr 1:244,400,204...244,408,662 		JBrowse link
G Ppp1r3c protein phosphatase 1, regulatory subunit 3C multiple interactions ISO [resveratrol co-treated with imiquimod] results in decreased expression of PPP1R3C mRNA CTD PMID:25965695 NCBI chr 1:234,460,958...234,465,961
Ensembl chr 1:234,460,652...234,465,961 		JBrowse link
G Rad51ap1 RAD51 associated protein 1 decreases expression ISO imiquimod results in decreased expression of RAD51AP1 mRNA CTD PMID:21878529 NCBI chr 4:159,759,454...159,772,524
Ensembl chr 4:159,759,459...159,772,524 		JBrowse link
G Rad51d RAD51 paralog D decreases expression ISO imiquimod results in decreased expression of RAD51D mRNA CTD PMID:21878529 NCBI chr10:67,805,720...67,824,452
Ensembl chr10:67,740,712...67,824,434 		JBrowse link
G Rad54l RAD54 like decreases expression ISO imiquimod results in decreased expression of RAD54L mRNA CTD PMID:21878529 NCBI chr 5:129,575,431...129,605,100
Ensembl chr 5:129,575,378...129,605,070 		JBrowse link
G Rorc RAR-related orphan receptor C increases expression
multiple interactions		 ISO imiquimod results in increased expression of RORC mRNA; imiquimod results in increased expression of RORC protein
(+)-JQ1 compound inhibits the reaction [imiquimod results in increased expression of RORC mRNA]; (+)-JQ1 compound inhibits the reaction [imiquimod results in increased expression of RORC protein]		 CTD PMID:26149470 NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907 		JBrowse link
G Ruvbl2 RuvB-like AAA ATPase 2 decreases expression ISO imiquimod results in decreased expression of RUVBL2 mRNA CTD PMID:21878529 NCBI chr 1:95,902,014...95,915,364
Ensembl chr 1:95,901,701...95,915,342 		JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO imiquimod inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO imiquimod inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904 		JBrowse link
G Ssrp1 structure specific recognition protein 1 decreases expression ISO imiquimod results in decreased expression of SSRP1 mRNA CTD PMID:21878529 NCBI chr 3:70,124,371...70,134,481
Ensembl chr 3:70,118,655...70,134,482 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression ISO imiquimod results in increased expression of STAT3 mRNA CTD PMID:26149470 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases secretion ISO Imiquimod results in increased secretion of TGFB1 protein CTD PMID:34740670 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO imiquimod results in increased expression of TIMP1 protein CTD PMID:14708627 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tlr7 toll-like receptor 7 multiple interactions
increases cleavage
affects binding		 ISO [Imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]; [Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of CD86 protein; [Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ICAM1 protein; [Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ITGAX protein; [Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased secretion of IL6 protein; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased cleavage of TLR7 protein]; Tetrachlorodibenzodioxin inhibits the reaction [[Imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]]; Tetrachlorodibenzodioxin inhibits the reaction [[Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ITGAX protein]; Tetrachlorodibenzodioxin promotes the reaction [[Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of CD86 protein]; Tetrachlorodibenzodioxin promotes the reaction [[Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ICAM1 protein]
Imiquimod binds to TLR7 protein		 CTD PMID:21097750 PMID:22916010 PMID:31093508 NCBI chr  X:27,027,380...27,054,309
Ensembl chr  X:27,027,425...27,054,754 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
increases expression		 ISO CGP 57380 inhibits the reaction [Imiquimod results in increased expression of TNF protein]; LRCH4 protein promotes the reaction [Imiquimod results in increased expression of TNF protein]
Cannabidiol promotes the reaction [Imiquimod results in increased secretion of TNF protein]
Imiquimod results in increased expression of TNF mRNA; Imiquimod results in increased expression of TNF protein		 CTD PMID:18032482 PMID:25965695 PMID:26149470 PMID:30523158 PMID:31093508 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Trex1 three prime repair exonuclease 1 increases expression ISO imiquimod results in increased expression of TREX1 mRNA CTD PMID:21878529 NCBI chr 8:109,706,613...109,707,913
Ensembl chr 8:109,706,613...109,708,796 		JBrowse link
G Trim63 tripartite motif containing 63 multiple interactions ISO [resveratrol co-treated with imiquimod] results in increased expression of TRIM63 mRNA CTD PMID:25965695 NCBI chr 5:146,533,492...146,547,332
Ensembl chr 5:146,533,507...146,547,322 		JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 decreases expression ISO imiquimod results in decreased expression of UHRF1 mRNA CTD PMID:21878529 NCBI chr 9:1,133,117...1,154,639
Ensembl chr 9:1,134,909...1,154,631 		JBrowse link
G Wrnip1 WRN helicase interacting protein 1 decreases expression ISO imiquimod results in decreased expression of WRNIP1 mRNA CTD PMID:21878529 NCBI chr17:31,621,410...31,641,659
Ensembl chr17:31,621,411...31,641,659 		JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor increases expression ISO imiquimod results in increased expression of XPC mRNA CTD PMID:21878529 NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      application 19781
        pharmaceutical 19624
          drug 19655
            antineoplastic agent 17669
              imiquimod 107
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic molecule 19856
                              organic cyclic compound 19612
                                organic heterocyclic compound 18824
                                  organic heteropolycyclic compound 18298
                                    organic heterotricyclic compound 15598
                                      imidazoquinoline 173
                                        imiquimod 107
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