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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:imiquimod
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Accession:CHEBI:36704 term browser browse the term
Definition:An imidazoquinoline fused [4,5-c] carrying isobutyl and amino substituents at N-1 and C-4 respectively. A prescription medication, it acts as an immune response modifier and is used to treat genital warts, superficial basal cell carcinoma, and actinic keratosis.
Synonyms:exact_synonym: 1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine
 related_synonym: 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine;   4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline;   Formula=C14H16N4;   InChI=1S/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17);   InChIKey=DOUYETYNHWVLEO-UHFFFAOYSA-N;   R 837;   SMILES=C1=2C=CC=CC2N=C(C=3N=CN(C13)CC(C)C)N;   imiquimodum
 xref: Beilstein:7710060;   CAS:99011-02-6;   DrugBank:DB00724;   Drug_Central:1429;   LINCS:LSM-5408
 xref_mesh: MESH:C056493
 xref: PMID:10861101;   PMID:15868314;   PMID:16217984;   PMID:18424373;   PMID:27548435;   PMID:28872561;   PMID:29422777;   PMID:29485187;   PMID:29505317;   PMID:29596875;   Patent:AU2005320890;   Patent:EP1831219;   Patent:KR20070102652;   Reaxys:7710060;   Wikipedia:Imiquimod



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imiquimod term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO epigallocatechin gallate inhibits the reaction [Imiquimod results in increased phosphorylation of AKT1 protein] CTD PMID:24990399 PMID:29402411 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 decreases expression ISO imiquimod results in decreased expression of APEX1 mRNA CTD PMID:21878529 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO imiquimod results in decreased expression of BCL2 protein CTD PMID:20033192 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Blm BLM RecQ like helicase decreases expression ISO imiquimod results in decreased expression of BLM mRNA CTD PMID:21878529 NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312
JBrowse link
G Brca2 BRCA2, DNA repair associated decreases expression ISO imiquimod results in decreased expression of BRCA2 mRNA CTD PMID:21878529 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567
JBrowse link
G Bst2 bone marrow stromal cell antigen 2 increases expression ISO Imiquimod results in increased expression of BST2 protein CTD PMID:31093508 NCBI chr16:18,217,404...18,220,979
Ensembl chr16:18,217,407...18,220,979
JBrowse link
G Casp1 caspase 1 increases activity
multiple interactions
ISO Imiquimod results in increased activity of CASP1 protein
[Dronabinol inhibits the reaction [Imiquimod results in increased activity of CASP1 protein]] which affects the localization of IL1B protein; Dronabinol inhibits the reaction [Imiquimod results in increased activity of CASP1 protein]
CTD PMID:31383729 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
ISO imiquimod results in increased activity of CASP3 protein
imiquimod results in increased cleavage of CASP3 protein
CTD PMID:12902443 PMID:20033192 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases secretion ISO Imiquimod results in increased secretion of CCL2 protein CTD PMID:34740670 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cd274 CD274 molecule increases expression ISO Imiquimod results in increased expression of CD274 protein CTD PMID:31093508 NCBI chr 1:227,116,627...227,137,379
Ensembl chr 1:227,116,649...227,134,450
JBrowse link
G Cd40 CD40 molecule increases expression
multiple interactions
ISO Imiquimod results in increased expression of CD40 protein
LGMN gene mutant form inhibits the reaction [Imiquimod results in increased expression of CD40 protein]
CTD PMID:22916010 PMID:31093508 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Cd80 Cd80 molecule increases expression ISO Imiquimod results in increased expression of CD80 protein CTD PMID:31093508 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
JBrowse link
G Cd86 CD86 molecule multiple interactions
increases expression
ISO [Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of CD86 protein; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased expression of CD86 protein]; Tetrachlorodibenzodioxin promotes the reaction [[Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of CD86 protein] CTD PMID:21097750 PMID:22916010 PMID:31093508 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Chaf1a chromatin assembly factor 1 subunit A decreases expression ISO imiquimod results in decreased expression of CHAF1A mRNA CTD PMID:21878529 NCBI chr 9:873,953...900,701
Ensembl chr 9:874,051...900,654
JBrowse link
G Chaf1b chromatin assembly factor 1 subunit B decreases expression ISO imiquimod results in decreased expression of CHAF1B mRNA CTD PMID:21878529 NCBI chr11:33,200,894...33,221,076
Ensembl chr11:33,200,981...33,221,070
JBrowse link
G Ctsb cathepsin B increases activity ISO Imiquimod results in increased activity of CTSB protein CTD PMID:22916010 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
JBrowse link
G Ctsk cathepsin K increases activity ISO Imiquimod results in increased activity of CTSK protein CTD PMID:22916010 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
JBrowse link
G Ctsl cathepsin L increases activity ISO Imiquimod results in increased activity of CTSL protein CTD PMID:22916010 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
JBrowse link
G Ctss cathepsin S increases activity ISO Imiquimod results in increased activity of CTSS protein CTD PMID:22916010 NCBI chr 2:183,089,192...183,114,483
Ensembl chr 2:183,086,437...183,114,483
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO [Pam(3)CSK(4) peptide co-treated with Antigens, Bacterial co-treated with Poly I-C co-treated with Lipopolysaccharides co-treated with FSL-1 lipoprotein, synthetic co-treated with imiquimod co-treated with Polyribonucleotides co-treated with ProMune] results in increased expression of CXCL10 protein; Particulate Matter inhibits the reaction [[Pam(3)CSK(4) peptide co-treated with Antigens, Bacterial co-treated with Poly I-C co-treated with Lipopolysaccharides co-treated with FSL-1 lipoprotein, synthetic co-treated with imiquimod co-treated with Polyribonucleotides co-treated with ProMune] results in increased expression of CXCL10 protein]; Vehicle Emissions inhibits the reaction [[Pam(3)CSK(4) peptide co-treated with Antigens, Bacterial co-treated with Poly I-C co-treated with Lipopolysaccharides co-treated with FSL-1 lipoprotein, synthetic co-treated with imiquimod co-treated with Polyribonucleotides co-treated with ProMune] results in increased expression of CXCL10 protein] CTD PMID:28655636 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases secretion ISO Imiquimod results in increased secretion of CXCL1 protein CTD PMID:22916010 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing
multiple interactions
affects metabolic processing
increases chemical synthesis
ISO CYP1A1 protein results in increased metabolism of Imiquimod
CYP1A1 protein affects the reaction [beta-Naphthoflavone results in increased metabolism of Imiquimod]
CYP1A1 protein affects the metabolism of Imiquimod
[CYP1A1 protein results in increased metabolism of Imiquimod] which results in increased chemical synthesis of Imiquimod metabolite
CYP1A1 protein results in increased chemical synthesis of Imiquimod metabolite
CTD PMID:31111189 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
affects metabolic processing
increases chemical synthesis
increases metabolic processing
ISO [CYP1A2 protein results in increased metabolism of Imiquimod] which results in increased chemical synthesis of Imiquimod metabolite
CYP1A2 protein affects the metabolism of Imiquimod
CYP1A2 protein results in increased chemical synthesis of Imiquimod metabolite
CYP1A2 protein affects the reaction [beta-Naphthoflavone results in increased metabolism of Imiquimod]
CTD PMID:31111189 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases metabolic processing ISO CYP2C19 protein results in increased metabolism of Imiquimod CTD PMID:31111189 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing ISO CYP2D6 protein results in increased metabolism of Imiquimod CTD PMID:31111189 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit decreases expression ISO imiquimod results in decreased expression of ERCC2 mRNA CTD PMID:21878529 NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102
JBrowse link
G Ercc5 ERCC excision repair 5, endonuclease increases expression ISO imiquimod results in increased expression of ERCC5 mRNA CTD PMID:21878529 NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472
JBrowse link
G Fancl FA complementation group L decreases expression ISO imiquimod results in decreased expression of FANCL mRNA CTD PMID:21878529 NCBI chr14:100,249,733...100,317,958
Ensembl chr14:100,248,875...100,314,255
JBrowse link
G Fbh1 F-box DNA helicase 1 decreases expression ISO imiquimod results in decreased expression of FBH1 mRNA CTD PMID:21878529 NCBI chr17:66,749,506...66,787,590
Ensembl chr17:66,749,534...66,787,590
JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression ISO imiquimod results in decreased expression of FGF2 CTD PMID:16368197 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Gtf2h3 general transcription factor IIH subunit 3 decreases expression ISO imiquimod results in decreased expression of GTF2H3 mRNA CTD PMID:21878529 NCBI chr12:32,009,010...32,025,484
Ensembl chr12:32,009,014...32,025,497
JBrowse link
G Gtf2h4 general transcription factor 2H subunit 4 decreases expression ISO imiquimod results in decreased expression of GTF2H4 mRNA CTD PMID:21878529 NCBI chr20:3,071,328...3,076,990
Ensembl chr20:3,071,328...3,076,984
JBrowse link
G Gzmb granzyme B multiple interactions ISO Imiquimod results in increased expression of and results in increased secretion of GZMB protein CTD PMID:31093508 NCBI chr15:30,343,361...30,346,792
Ensembl chr15:30,173,603...30,346,814
JBrowse link
G H2ax H2A.X variant histone decreases expression ISO Imiquimod results in decreased expression of H2AX mRNA CTD PMID:21878529 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO [imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ICAM1 protein; Tetrachlorodibenzodioxin promotes the reaction [[imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ICAM1 protein] CTD PMID:21097750 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Hydroxychloroquine co-treated with Imiquimod] results in increased secretion of IL10 protein CTD PMID:31082466 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il11 interleukin 11 multiple interactions
decreases expression
ISO ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL11 mRNA] CTD PMID:31054998 NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129
JBrowse link
G Il11ra1 interleukin 11 receptor subunit alpha 1 multiple interactions
decreases expression
ISO ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL11RA1 mRNA] CTD PMID:31054998 NCBI chr 5:56,931,824...56,941,408
Ensembl chr 5:56,935,516...56,941,408
JBrowse link
G Il12a interleukin 12A multiple interactions
increases secretion
ISO [imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]; Tetrachlorodibenzodioxin inhibits the reaction [[imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]]
Imiquimod results in increased secretion of IL12A protein
CTD PMID:21097750 PMID:31093508 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B multiple interactions
increases secretion
increases expression
ISO [Imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]; ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL12B mRNA]; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased secretion of IL12B protein]; Tetrachlorodibenzodioxin inhibits the reaction [[Imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]] CTD PMID:21097750 PMID:22916010 PMID:31054998 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 multiple interactions
increases expression
ISO ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL13RA1 mRNA] CTD PMID:31054998 NCBI chr  X:115,348,860...115,408,682
Ensembl chr  X:115,348,860...115,408,681
JBrowse link
G Il13ra2 interleukin 13 receptor subunit alpha 2 increases expression ISO Imiquimod results in increased expression of IL13RA2 mRNA CTD PMID:31054998 NCBI chr  X:111,002,590...111,074,053
Ensembl chr  X:111,002,592...111,072,381
JBrowse link
G Il17a interleukin 17A multiple interactions
increases expression
increases secretion
ISO (+)-JQ1 compound inhibits the reaction [Imiquimod results in increased expression of IL17A mRNA]; (+)-JQ1 compound inhibits the reaction [Imiquimod results in increased secretion of IL17A protein]; ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL17A mRNA]; ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL17A protein]; Resveratrol inhibits the reaction [Imiquimod results in increased expression of IL17A mRNA]; SR 1078 inhibits the reaction [(+)-JQ1 compound inhibits the reaction [Imiquimod results in increased expression of IL17A mRNA]]; SR 1078 inhibits the reaction [(+)-JQ1 compound inhibits the reaction [Imiquimod results in increased secretion of IL17A protein]]
Imiquimod results in increased expression of IL17A mRNA; Imiquimod results in increased expression of IL17A protein
imiquimod results in increased secretion of IL17A protein
CTD PMID:25965695 PMID:26149470 PMID:31054998 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il17b interleukin 17B decreases expression
multiple interactions
ISO Imiquimod results in decreased expression of IL17B mRNA
ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL17B mRNA]
CTD PMID:31054998 NCBI chr18:55,141,194...55,145,565
Ensembl chr18:55,141,194...55,145,565
JBrowse link
G Il17rb interleukin 17 receptor B decreases expression
multiple interactions
ISO Imiquimod results in decreased expression of IL17RB mRNA
ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL17RB mRNA]
CTD PMID:31054998 NCBI chr16:5,180,431...5,194,125
Ensembl chr16:5,180,432...5,194,125
JBrowse link
G Il18 interleukin 18 increases expression
multiple interactions
ISO Imiquimod results in increased expression of IL18 mRNA
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL18 mRNA]
CTD PMID:31054998 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il18rap interleukin 18 receptor accessory protein multiple interactions
increases expression
ISO ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL18RAP mRNA] CTD PMID:31054998 NCBI chr 9:42,768,112...42,800,964
Ensembl chr 9:42,768,220...42,800,959
JBrowse link
G Il19 interleukin 19 increases expression
multiple interactions
ISO imiquimod results in increased expression of IL19 mRNA
resveratrol inhibits the reaction [imiquimod results in increased expression of IL19 mRNA]
CTD PMID:25965695 NCBI chr13:42,397,715...42,411,637
Ensembl chr13:42,399,138...42,405,473
JBrowse link
G Il1a interleukin 1 alpha multiple interactions
increases expression
ISO ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL1A mRNA] CTD PMID:31054998 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta increases secretion
multiple interactions
increases expression
ISO Imiquimod results in increased secretion of IL1B protein
[Dronabinol inhibits the reaction [Imiquimod results in increased activity of CASP1 protein]] which affects the localization of IL1B protein; Cannabidiol inhibits the reaction [Imiquimod results in increased secretion of IL1B protein]; Dronabinol inhibits the reaction [Imiquimod results in increased expression of IL1B mRNA]; Dronabinol inhibits the reaction [Imiquimod results in increased secretion of IL1B protein]; JHW 015 inhibits the reaction [Imiquimod results in increased secretion of IL1B protein]
Imiquimod results in increased expression of IL1B mRNA; Imiquimod results in increased expression of IL1B protein
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL1B mRNA]; ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL1B protein]
CTD PMID:18403674 PMID:31054998 PMID:31082466 PMID:31383729 PMID:34740670 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1f10 interleukin 1 family member 10 decreases expression
multiple interactions
ISO Imiquimod results in decreased expression of IL1F10 mRNA
ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL1F10 mRNA]
CTD PMID:31054998 NCBI chr 3:7,072,511...7,075,439
Ensembl chr 3:7,072,511...7,075,439
JBrowse link
G Il1rap interleukin 1 receptor accessory protein increases expression ISO Imiquimod results in increased expression of IL1RAP mRNA CTD PMID:31054998 NCBI chr11:74,062,999...74,199,530
Ensembl chr11:74,070,304...74,199,530
JBrowse link
G Il2 interleukin 2 increases secretion ISO Imiquimod results in increased secretion of IL2 protein CTD PMID:34740670 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il20 interleukin 20 increases expression
multiple interactions
ISO Imiquimod results in increased expression of IL20 mRNA
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL20 mRNA]
CTD PMID:31054998 NCBI chr13:42,380,981...42,384,625
Ensembl chr13:42,380,981...42,384,625
JBrowse link
G Il20rb interleukin 20 receptor subunit beta increases expression
multiple interactions
ISO Imiquimod results in increased expression of IL20RB mRNA
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL20RB mRNA]
CTD PMID:31054998 NCBI chr 8:100,979,085...101,010,829
Ensembl chr 8:100,980,383...101,009,942
JBrowse link
G Il22ra1 interleukin 22 receptor subunit alpha 1 increases expression
multiple interactions
ISO Imiquimod results in increased expression of IL22RA1 mRNA
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL22RA1 mRNA]
CTD PMID:31054998 NCBI chr 5:147,961,496...147,986,296
Ensembl chr 5:147,961,349...147,986,296
JBrowse link
G Il23a interleukin 23 subunit alpha increases secretion
multiple interactions
increases expression
ISO imiquimod results in increased secretion of IL23A protein
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL23A mRNA]; ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL23A protein]
Imiquimod results in increased expression of IL23A mRNA; Imiquimod results in increased expression of IL23A protein
CTD PMID:25965695 PMID:26149470 PMID:31054998 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
G Il27 interleukin 27 multiple interactions
increases expression
ISO ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL27 mRNA] CTD PMID:31054998 NCBI chr 1:181,173,108...181,178,720
Ensembl chr 1:181,173,372...181,178,582
JBrowse link
G Il33 interleukin 33 multiple interactions
increases expression
ISO ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL33 mRNA] CTD PMID:31054998 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
JBrowse link
G Il36a interleukin 36, alpha increases expression
multiple interactions
ISO Imiquimod results in increased expression of IL36A mRNA
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL36A mRNA]
CTD PMID:31054998 NCBI chr 3:6,996,851...7,001,400
Ensembl chr 3:6,996,851...7,001,400
JBrowse link
G Il36b interleukin 36, beta increases expression
multiple interactions
ISO Imiquimod results in increased expression of IL36B mRNA
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL36B mRNA]
CTD PMID:31054998 NCBI chr 3:7,024,862...7,122,489
Ensembl chr 3:7,021,973...7,031,619
JBrowse link
G Il36g interleukin 36, gamma multiple interactions
increases expression
ISO ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL36G mRNA] CTD PMID:31054998 NCBI chr 3:6,948,323...6,954,485
Ensembl chr 3:6,948,297...6,954,480
JBrowse link
G Il36rn interleukin 36 receptor antagonist multiple interactions
increases expression
ISO ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL36RN mRNA] CTD PMID:31054998 NCBI chr 3:7,044,419...7,051,016
Ensembl chr 3:7,044,406...7,051,016
JBrowse link
G Il4 interleukin 4 increases secretion ISO Imiquimod results in increased secretion of IL4 protein CTD PMID:34740670 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 multiple interactions
increases secretion
ISO [Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased secretion of IL6 protein; concanamycin B inhibits the reaction [Imiquimod results in increased secretion of IL6 protein]; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased secretion of IL6 protein]; MV026630 inhibits the reaction [Imiquimod results in increased secretion of IL6 protein]
[Hydroxychloroquine co-treated with Imiquimod] results in increased secretion of IL6 protein; Cannabidiol promotes the reaction [Imiquimod results in increased secretion of IL6 protein]
CTD PMID:21097750 PMID:22916010 PMID:31082466 PMID:31093508 PMID:31383729 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Il7 interleukin 7 increases expression
multiple interactions
ISO Imiquimod results in increased expression of IL7 mRNA
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL7 mRNA]
CTD PMID:31054998 NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075
JBrowse link
G Il7r interleukin 7 receptor multiple interactions
increases expression
ISO ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL7R mRNA] CTD PMID:31054998 NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757
JBrowse link
G Il9r interleukin 9 receptor decreases expression
multiple interactions
ISO Imiquimod results in decreased expression of IL9R mRNA
ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL9R mRNA]
CTD PMID:31054998 NCBI chr10:15,431,706...15,444,144
Ensembl chr10:15,431,706...15,441,990
JBrowse link
G Irak2 interleukin-1 receptor-associated kinase 2 multiple interactions
increases expression
ISO ferulic acid inhibits the reaction [Imiquimod results in increased expression of IRAK2 mRNA] CTD PMID:31054998 NCBI chr 4:146,786,004...146,842,615
Ensembl chr 4:146,786,100...146,842,602
JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 increases expression
multiple interactions
ISO Imiquimod results in increased expression of IRAK3 mRNA
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IRAK3 mRNA]
CTD PMID:31054998 NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121
JBrowse link
G Itgax integrin subunit alpha X multiple interactions ISO [imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ITGAX protein; Tetrachlorodibenzodioxin inhibits the reaction [[imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ITGAX protein] CTD PMID:21097750 NCBI chr 1:182,709,653...182,740,709
Ensembl chr 1:182,719,609...182,740,698
JBrowse link
G Kif22 kinesin family member 22 decreases expression ISO imiquimod results in decreased expression of KIF22 mRNA CTD PMID:21878529 NCBI chr 1:181,635,347...181,650,351
Ensembl chr 1:181,635,183...181,650,401
JBrowse link
G Lgmn legumain increases activity
multiple interactions
ISO Imiquimod results in increased activity of LGMN protein
LGMN gene mutant form inhibits the reaction [Imiquimod results in increased cleavage of TLR7 protein]; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased expression of CD40 protein]; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased expression of CD86 protein]; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased secretion of IL12B protein]; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased secretion of IL6 protein]
CTD PMID:22916010 NCBI chr 6:121,544,048...121,582,495
Ensembl chr 6:121,544,053...121,582,480
JBrowse link
G Lig1 DNA ligase 1 decreases expression ISO imiquimod results in decreased expression of LIG1 mRNA CTD PMID:21878529 NCBI chr 1:74,165,688...74,204,400
Ensembl chr 1:74,165,842...74,204,413
JBrowse link
G Lrch4 leucine rich repeats and calponin homology domain containing 4 multiple interactions ISO LRCH4 protein promotes the reaction [Imiquimod results in increased expression of TNF protein] CTD PMID:30523158 NCBI chr12:19,057,582...19,072,573
Ensembl chr12:19,057,587...19,068,577
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO imiquimod results in decreased phosphorylation of MAPK1 protein CTD PMID:20033192 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO imiquimod results in decreased phosphorylation of MAPK3 protein CTD PMID:20033192 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mlh1 mutL homolog 1 decreases expression ISO imiquimod results in decreased expression of MLH1 mRNA CTD PMID:21878529 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases activity ISO imiquimod results in decreased activity of MMP9 protein CTD PMID:14708627 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpg N-methylpurine-DNA glycosylase decreases expression ISO imiquimod results in decreased expression of MPG mRNA CTD PMID:21878529 NCBI chr10:15,396,246...15,402,528
Ensembl chr10:15,395,782...15,402,520
JBrowse link
G Mpo myeloperoxidase increases activity
multiple interactions
ISO imiquimod results in increased activity of MPO protein
(+)-JQ1 compound inhibits the reaction [imiquimod results in increased activity of MPO protein]; SR 1078 inhibits the reaction [(+)-JQ1 compound inhibits the reaction [imiquimod results in increased activity of MPO protein]]
CTD PMID:26149470 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease decreases expression ISO imiquimod results in decreased expression of MRE11A mRNA CTD PMID:21878529 NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279
JBrowse link
G Msh2 mutS homolog 2 decreases expression ISO imiquimod results in decreased expression of MSH2 mRNA CTD PMID:21878529 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938
JBrowse link
G Nudt1 nudix hydrolase 1 decreases expression ISO imiquimod results in decreased expression of NUDT1 mRNA CTD PMID:21878529 NCBI chr12:14,302,514...14,309,559
Ensembl chr12:14,302,694...14,305,826
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions ISO [resveratrol co-treated with imiquimod] results in increased expression of PCK1 mRNA CTD PMID:25965695 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component decreases expression ISO imiquimod results in decreased expression of PMS2 mRNA CTD PMID:21878529 NCBI chr12:10,676,819...10,701,161
Ensembl chr12:10,676,764...10,701,066
JBrowse link
G Pole DNA polymerase epsilon, catalytic subunit decreases expression ISO imiquimod results in decreased expression of POLE mRNA CTD PMID:21878529 NCBI chr12:46,345,420...46,393,984
Ensembl chr12:46,345,420...46,393,939
JBrowse link
G Poll DNA polymerase lambda decreases expression ISO imiquimod results in decreased expression of POLL mRNA CTD PMID:21878529 NCBI chr 1:244,400,202...244,408,762
Ensembl chr 1:244,400,204...244,408,662
JBrowse link
G Ppp1r3c protein phosphatase 1, regulatory subunit 3C multiple interactions ISO [resveratrol co-treated with imiquimod] results in decreased expression of PPP1R3C mRNA CTD PMID:25965695 NCBI chr 1:234,460,958...234,465,961
Ensembl chr 1:234,460,652...234,465,961
JBrowse link
G Rad51ap1 RAD51 associated protein 1 decreases expression ISO imiquimod results in decreased expression of RAD51AP1 mRNA CTD PMID:21878529 NCBI chr 4:159,759,454...159,772,524
Ensembl chr 4:159,759,459...159,772,524
JBrowse link
G Rad51d RAD51 paralog D decreases expression ISO imiquimod results in decreased expression of RAD51D mRNA CTD PMID:21878529 NCBI chr10:67,805,720...67,824,452
Ensembl chr10:67,740,712...67,824,434
JBrowse link
G Rad54l RAD54 like decreases expression ISO imiquimod results in decreased expression of RAD54L mRNA CTD PMID:21878529 NCBI chr 5:129,575,431...129,605,100
Ensembl chr 5:129,575,378...129,605,070
JBrowse link
G Rorc RAR-related orphan receptor C increases expression
multiple interactions
ISO imiquimod results in increased expression of RORC mRNA; imiquimod results in increased expression of RORC protein
(+)-JQ1 compound inhibits the reaction [imiquimod results in increased expression of RORC mRNA]; (+)-JQ1 compound inhibits the reaction [imiquimod results in increased expression of RORC protein]
CTD PMID:26149470 NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907
JBrowse link
G Ruvbl2 RuvB-like AAA ATPase 2 decreases expression ISO imiquimod results in decreased expression of RUVBL2 mRNA CTD PMID:21878529 NCBI chr 1:95,902,014...95,915,364
Ensembl chr 1:95,901,701...95,915,342
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO imiquimod inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO imiquimod inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
JBrowse link
G Ssrp1 structure specific recognition protein 1 decreases expression ISO imiquimod results in decreased expression of SSRP1 mRNA CTD PMID:21878529 NCBI chr 3:70,124,371...70,134,481
Ensembl chr 3:70,118,655...70,134,482
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression ISO imiquimod results in increased expression of STAT3 mRNA CTD PMID:26149470 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases secretion ISO Imiquimod results in increased secretion of TGFB1 protein CTD PMID:34740670 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO imiquimod results in increased expression of TIMP1 protein CTD PMID:14708627 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tlr7 toll-like receptor 7 multiple interactions
increases cleavage
affects binding
ISO [Imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]; [Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of CD86 protein; [Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ICAM1 protein; [Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ITGAX protein; [Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased secretion of IL6 protein; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased cleavage of TLR7 protein]; Tetrachlorodibenzodioxin inhibits the reaction [[Imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]]; Tetrachlorodibenzodioxin inhibits the reaction [[Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ITGAX protein]; Tetrachlorodibenzodioxin promotes the reaction [[Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of CD86 protein]; Tetrachlorodibenzodioxin promotes the reaction [[Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ICAM1 protein]
Imiquimod binds to TLR7 protein
CTD PMID:21097750 PMID:22916010 PMID:31093508 NCBI chr  X:27,027,380...27,054,309
Ensembl chr  X:27,027,425...27,054,754
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
increases expression
ISO CGP 57380 inhibits the reaction [Imiquimod results in increased expression of TNF protein]; LRCH4 protein promotes the reaction [Imiquimod results in increased expression of TNF protein]
Cannabidiol promotes the reaction [Imiquimod results in increased secretion of TNF protein]
Imiquimod results in increased expression of TNF mRNA; Imiquimod results in increased expression of TNF protein
CTD PMID:18032482 PMID:25965695 PMID:26149470 PMID:30523158 PMID:31093508 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Trex1 three prime repair exonuclease 1 increases expression ISO imiquimod results in increased expression of TREX1 mRNA CTD PMID:21878529 NCBI chr 8:109,706,613...109,707,913
Ensembl chr 8:109,706,613...109,708,796
JBrowse link
G Trim63 tripartite motif containing 63 multiple interactions ISO [resveratrol co-treated with imiquimod] results in increased expression of TRIM63 mRNA CTD PMID:25965695 NCBI chr 5:146,533,492...146,547,332
Ensembl chr 5:146,533,507...146,547,322
JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 decreases expression ISO imiquimod results in decreased expression of UHRF1 mRNA CTD PMID:21878529 NCBI chr 9:1,133,117...1,154,639
Ensembl chr 9:1,134,909...1,154,631
JBrowse link
G Wrnip1 WRN helicase interacting protein 1 decreases expression ISO imiquimod results in decreased expression of WRNIP1 mRNA CTD PMID:21878529 NCBI chr17:31,621,410...31,641,659
Ensembl chr17:31,621,411...31,641,659
JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor increases expression ISO imiquimod results in increased expression of XPC mRNA CTD PMID:21878529 NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      application 19781
        pharmaceutical 19624
          drug 19655
            antineoplastic agent 17669
              imiquimod 107
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic molecule 19856
                              organic cyclic compound 19612
                                organic heterocyclic compound 18824
                                  organic heteropolycyclic compound 18298
                                    organic heterotricyclic compound 15598
                                      imidazoquinoline 173
                                        imiquimod 107
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