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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions increases phosphorylation |
ISO |
epigallocatechin gallate inhibits the reaction [Imiquimod results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:24990399 PMID:29402411 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Apex1 |
apurinic/apyrimidinic endodeoxyribonuclease 1 |
decreases expression |
ISO |
imiquimod results in decreased expression of APEX1 mRNA |
CTD |
PMID:21878529 |
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NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
imiquimod results in decreased expression of BCL2 protein |
CTD |
PMID:20033192 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Blm |
BLM RecQ like helicase |
decreases expression |
ISO |
imiquimod results in decreased expression of BLM mRNA |
CTD |
PMID:21878529 |
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NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312
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G |
Brca2 |
BRCA2, DNA repair associated |
decreases expression |
ISO |
imiquimod results in decreased expression of BRCA2 mRNA |
CTD |
PMID:21878529 |
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NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567
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G |
Bst2 |
bone marrow stromal cell antigen 2 |
increases expression |
ISO |
Imiquimod results in increased expression of BST2 protein |
CTD |
PMID:31093508 |
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NCBI chr16:18,216,605...18,220,979
Ensembl chr16:18,217,407...18,220,979
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G |
Casp1 |
caspase 1 |
increases activity multiple interactions |
ISO |
Imiquimod results in increased activity of CASP1 protein [Dronabinol inhibits the reaction [Imiquimod results in increased activity of CASP1 protein]] which affects the localization of IL1B protein; Dronabinol inhibits the reaction [Imiquimod results in increased activity of CASP1 protein] [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Imiquimod] results in increased cleavage of CASP1 protein; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Imiquimod] results in increased cleavage of CASP1 protein] |
CTD |
PMID:31383729 PMID:36577999 |
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NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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G |
Casp3 |
caspase 3 |
increases activity increases cleavage |
ISO |
imiquimod results in increased activity of CASP3 protein imiquimod results in increased cleavage of CASP3 protein |
CTD |
PMID:12902443 PMID:20033192 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
increases secretion |
ISO |
Imiquimod results in increased secretion of CCL2 protein |
CTD |
PMID:34740670 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Cd274 |
CD274 molecule |
increases expression |
ISO |
Imiquimod results in increased expression of CD274 protein |
CTD |
PMID:31093508 |
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NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450
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G |
Cd40 |
CD40 molecule |
increases expression multiple interactions |
ISO |
Imiquimod results in increased expression of CD40 protein LGMN gene mutant form inhibits the reaction [Imiquimod results in increased expression of CD40 protein] |
CTD |
PMID:22916010 PMID:31093508 |
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NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
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G |
Cd80 |
Cd80 molecule |
increases expression |
ISO |
Imiquimod results in increased expression of CD80 protein |
CTD |
PMID:31093508 |
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NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
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G |
Cd86 |
CD86 molecule |
multiple interactions increases expression |
ISO |
[Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of CD86 protein; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased expression of CD86 protein]; Tetrachlorodibenzodioxin promotes the reaction [[Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of CD86 protein] |
CTD |
PMID:21097750 PMID:22916010 PMID:31093508 |
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NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
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G |
Chaf1a |
chromatin assembly factor 1 subunit A |
decreases expression |
ISO |
imiquimod results in decreased expression of CHAF1A mRNA |
CTD |
PMID:21878529 |
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NCBI chr 9:873,953...900,701
Ensembl chr 9:874,051...900,654
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G |
Chaf1b |
chromatin assembly factor 1 subunit B |
decreases expression |
ISO |
imiquimod results in decreased expression of CHAF1B mRNA |
CTD |
PMID:21878529 |
|
NCBI chr11:33,200,894...33,221,076
Ensembl chr11:33,200,981...33,221,070
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G |
Ctsb |
cathepsin B |
increases activity |
ISO |
Imiquimod results in increased activity of CTSB protein |
CTD |
PMID:22916010 |
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NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
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G |
Ctsk |
cathepsin K |
increases activity |
ISO |
Imiquimod results in increased activity of CTSK protein |
CTD |
PMID:22916010 |
|
NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
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G |
Ctsl |
cathepsin L |
increases activity |
ISO |
Imiquimod results in increased activity of CTSL protein |
CTD |
PMID:22916010 |
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NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
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G |
Ctss |
cathepsin S |
increases activity |
ISO |
Imiquimod results in increased activity of CTSS protein |
CTD |
PMID:22916010 |
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NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483
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G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
multiple interactions |
ISO |
[Pam(3)CSK(4) peptide co-treated with Antigens, Bacterial co-treated with Poly I-C co-treated with Lipopolysaccharides co-treated with FSL-1 lipoprotein, synthetic co-treated with imiquimod co-treated with Polyribonucleotides co-treated with ProMune] results in increased expression of CXCL10 protein; Particulate Matter inhibits the reaction [[Pam(3)CSK(4) peptide co-treated with Antigens, Bacterial co-treated with Poly I-C co-treated with Lipopolysaccharides co-treated with FSL-1 lipoprotein, synthetic co-treated with imiquimod co-treated with Polyribonucleotides co-treated with ProMune] results in increased expression of CXCL10 protein]; Vehicle Emissions inhibits the reaction [[Pam(3)CSK(4) peptide co-treated with Antigens, Bacterial co-treated with Poly I-C co-treated with Lipopolysaccharides co-treated with FSL-1 lipoprotein, synthetic co-treated with imiquimod co-treated with Polyribonucleotides co-treated with ProMune] results in increased expression of CXCL10 protein] |
CTD |
PMID:28655636 |
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NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
increases secretion |
ISO |
Imiquimod results in increased secretion of CXCL1 protein |
CTD |
PMID:22916010 |
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NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases metabolic processing increases chemical synthesis multiple interactions affects metabolic processing |
ISO |
CYP1A1 protein results in increased metabolism of Imiquimod CYP1A1 protein results in increased chemical synthesis of Imiquimod metabolite [CYP1A1 protein results in increased metabolism of Imiquimod] which results in increased chemical synthesis of Imiquimod metabolite CYP1A1 protein affects the metabolism of Imiquimod CYP1A1 protein affects the reaction [beta-Naphthoflavone results in increased metabolism of Imiquimod] |
CTD |
PMID:31111189 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions increases metabolic processing increases chemical synthesis affects metabolic processing |
ISO |
[CYP1A2 protein results in increased metabolism of Imiquimod] which results in increased chemical synthesis of Imiquimod metabolite CYP1A2 protein affects the reaction [beta-Naphthoflavone results in increased metabolism of Imiquimod] CYP1A2 protein results in increased chemical synthesis of Imiquimod metabolite CYP1A2 protein affects the metabolism of Imiquimod |
CTD |
PMID:31111189 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
increases metabolic processing |
ISO |
CYP2C19 protein results in increased metabolism of Imiquimod |
CTD |
PMID:31111189 |
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NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
increases metabolic processing |
ISO |
CYP2D6 protein results in increased metabolism of Imiquimod |
CTD |
PMID:31111189 |
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NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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G |
Ercc2 |
ERCC excision repair 2, TFIIH core complex helicase subunit |
decreases expression |
ISO |
imiquimod results in decreased expression of ERCC2 mRNA |
CTD |
PMID:21878529 |
|
NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102
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G |
Ercc5 |
ERCC excision repair 5, endonuclease |
increases expression |
ISO |
imiquimod results in increased expression of ERCC5 mRNA |
CTD |
PMID:21878529 |
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NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472
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G |
Fancl |
FA complementation group L |
decreases expression |
ISO |
imiquimod results in decreased expression of FANCL mRNA |
CTD |
PMID:21878529 |
|
NCBI chr14:100,249,733...100,317,958
Ensembl chr14:100,248,875...100,314,255
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G |
Fbh1 |
F-box DNA helicase 1 |
decreases expression |
ISO |
imiquimod results in decreased expression of FBH1 mRNA |
CTD |
PMID:21878529 |
|
NCBI chr17:66,749,506...66,787,590
Ensembl chr17:66,749,534...66,787,590
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G |
Fgf2 |
fibroblast growth factor 2 |
decreases expression |
ISO |
imiquimod results in decreased expression of FGF2 |
CTD |
PMID:16368197 |
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NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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G |
Gsdmd |
gasdermin D |
multiple interactions |
ISO |
[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Imiquimod] results in increased cleavage of GSDMD protein; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Imiquimod] results in increased cleavage of GSDMD protein] |
CTD |
PMID:36577999 |
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NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055
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G |
Gtf2h3 |
general transcription factor IIH subunit 3 |
decreases expression |
ISO |
imiquimod results in decreased expression of GTF2H3 mRNA |
CTD |
PMID:21878529 |
|
NCBI chr12:32,009,010...32,025,484
Ensembl chr12:32,009,014...32,025,497
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G |
Gtf2h4 |
general transcription factor 2H subunit 4 |
decreases expression |
ISO |
imiquimod results in decreased expression of GTF2H4 mRNA |
CTD |
PMID:21878529 |
|
NCBI chr20:3,071,328...3,076,990
Ensembl chr20:3,071,328...3,076,984
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G |
Gzmb |
granzyme B |
multiple interactions |
ISO |
Imiquimod results in increased expression of and results in increased secretion of GZMB protein |
CTD |
PMID:31093508 |
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NCBI chr15:30,343,352...30,346,814
Ensembl chr15:30,173,603...30,346,814
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G |
H2ax |
H2A.X variant histone |
decreases expression |
ISO |
Imiquimod results in decreased expression of H2AX mRNA |
CTD |
PMID:21878529 |
|
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
[imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ICAM1 protein; Tetrachlorodibenzodioxin promotes the reaction [[imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ICAM1 protein] |
CTD |
PMID:21097750 |
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NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
[Hydroxychloroquine co-treated with Imiquimod] results in increased secretion of IL10 protein |
CTD |
PMID:31082466 |
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il11 |
interleukin 11 |
multiple interactions decreases expression |
ISO |
ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL11 mRNA] |
CTD |
PMID:31054998 |
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NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129
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G |
Il11ra1 |
interleukin 11 receptor subunit alpha 1 |
multiple interactions decreases expression |
ISO |
ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL11RA1 mRNA] |
CTD |
PMID:31054998 |
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NCBI chr 5:56,931,824...56,941,408
Ensembl chr 5:56,935,516...56,941,408
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G |
Il12a |
interleukin 12A |
multiple interactions increases secretion |
ISO |
[imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]; Tetrachlorodibenzodioxin inhibits the reaction [[imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]] Imiquimod results in increased secretion of IL12A protein |
CTD |
PMID:21097750 PMID:31093508 |
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NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
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G |
Il12b |
interleukin 12B |
multiple interactions increases expression increases secretion |
ISO |
[Imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]; ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL12B mRNA]; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased secretion of IL12B protein]; Tetrachlorodibenzodioxin inhibits the reaction [[Imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]] |
CTD |
PMID:21097750 PMID:22916010 PMID:31054998 |
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NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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G |
Il13ra1 |
interleukin 13 receptor subunit alpha 1 |
multiple interactions increases expression |
ISO |
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL13RA1 mRNA] |
CTD |
PMID:31054998 |
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NCBI chr X:115,348,822...115,408,682
Ensembl chr X:115,348,860...115,408,681 Ensembl chr11:115,348,860...115,408,681
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G |
Il13ra2 |
interleukin 13 receptor subunit alpha 2 |
increases expression |
ISO |
Imiquimod results in increased expression of IL13RA2 mRNA |
CTD |
PMID:31054998 |
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NCBI chr X:111,002,590...111,074,053
Ensembl chr X:111,002,592...111,072,381
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G |
Il17a |
interleukin 17A |
multiple interactions increases secretion increases expression |
ISO |
(+)-JQ1 compound inhibits the reaction [Imiquimod results in increased expression of IL17A mRNA]; (+)-JQ1 compound inhibits the reaction [Imiquimod results in increased secretion of IL17A protein]; Chloroquine inhibits the reaction [Imiquimod results in increased expression of IL17A protein]; ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL17A mRNA]; ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL17A protein]; Resveratrol inhibits the reaction [Imiquimod results in increased expression of IL17A mRNA]; SR 1078 inhibits the reaction [(+)-JQ1 compound inhibits the reaction [Imiquimod results in increased expression of IL17A mRNA]]; SR 1078 inhibits the reaction [(+)-JQ1 compound inhibits the reaction [Imiquimod results in increased secretion of IL17A protein]] imiquimod results in increased secretion of IL17A protein Imiquimod results in increased expression of IL17A mRNA; Imiquimod results in increased expression of IL17A protein |
CTD |
PMID:25965695 PMID:26149470 PMID:31054998 PMID:36002070 |
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NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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G |
Il17b |
interleukin 17B |
decreases expression multiple interactions |
ISO |
Imiquimod results in decreased expression of IL17B mRNA ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL17B mRNA] |
CTD |
PMID:31054998 |
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NCBI chr18:55,141,194...55,145,565
Ensembl chr18:55,141,194...55,145,565
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G |
Il17rb |
interleukin 17 receptor B |
decreases expression multiple interactions |
ISO |
Imiquimod results in decreased expression of IL17RB mRNA ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL17RB mRNA] |
CTD |
PMID:31054998 |
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NCBI chr16:5,180,431...5,194,125
Ensembl chr16:5,180,432...5,194,125
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G |
Il18 |
interleukin 18 |
increases expression multiple interactions |
ISO |
Imiquimod results in increased expression of IL18 mRNA ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL18 mRNA] |
CTD |
PMID:31054998 |
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NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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G |
Il18rap |
interleukin 18 receptor accessory protein |
multiple interactions increases expression |
ISO |
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL18RAP mRNA] |
CTD |
PMID:31054998 |
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NCBI chr 9:42,768,112...42,800,964
Ensembl chr 9:42,768,220...42,800,959
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G |
Il19 |
interleukin 19 |
increases expression multiple interactions |
ISO |
imiquimod results in increased expression of IL19 mRNA resveratrol inhibits the reaction [imiquimod results in increased expression of IL19 mRNA] |
CTD |
PMID:25965695 |
|
NCBI chr13:42,397,715...42,411,637
Ensembl chr13:42,399,138...42,405,473
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G |
Il1a |
interleukin 1 alpha |
multiple interactions increases expression |
ISO |
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL1A mRNA] |
CTD |
PMID:31054998 |
|
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
increases secretion multiple interactions increases expression |
ISO |
Imiquimod results in increased secretion of IL1B protein [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Imiquimod] results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Imiquimod] results in increased secretion of IL1B protein; Chloroquine inhibits the reaction [Imiquimod results in increased expression of IL1B protein]; Chlorquinaldol inhibits the reaction [[Lipopolysaccharides co-treated with Imiquimod] results in increased secretion of IL1B protein]; ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL1B mRNA]; ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL1B protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Imiquimod] results in increased secretion of IL1B protein] Imiquimod results in increased expression of IL1B mRNA; Imiquimod results in increased expression of IL1B protein [Dronabinol inhibits the reaction [Imiquimod results in increased activity of CASP1 protein]] which affects the localization of IL1B protein; Cannabidiol inhibits the reaction [Imiquimod results in increased secretion of IL1B protein]; Dronabinol inhibits the reaction [Imiquimod results in increased expression of IL1B mRNA]; Dronabinol inhibits the reaction [Imiquimod results in increased secretion of IL1B protein]; JHW 015 inhibits the reaction [Imiquimod results in increased secretion of IL1B protein] |
CTD |
PMID:18403674 PMID:31054998 PMID:31082466 PMID:31383729 PMID:34740670 PMID:36002070 PMID:36577999 More...
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il1f10 |
interleukin 1 family member 10 |
decreases expression multiple interactions |
ISO |
Imiquimod results in decreased expression of IL1F10 mRNA ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL1F10 mRNA] |
CTD |
PMID:31054998 |
|
NCBI chr 3:7,072,511...7,075,439
Ensembl chr 3:7,072,511...7,075,439
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G |
Il1rap |
interleukin 1 receptor accessory protein |
increases expression |
ISO |
Imiquimod results in increased expression of IL1RAP mRNA |
CTD |
PMID:31054998 |
|
NCBI chr11:74,062,999...74,199,530
Ensembl chr11:74,070,304...74,199,530
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G |
Il2 |
interleukin 2 |
increases secretion |
ISO |
Imiquimod results in increased secretion of IL2 protein |
CTD |
PMID:34740670 |
|
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Il20 |
interleukin 20 |
increases expression multiple interactions |
ISO |
Imiquimod results in increased expression of IL20 mRNA ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL20 mRNA] |
CTD |
PMID:31054998 |
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NCBI chr13:42,380,981...42,384,625
Ensembl chr13:42,380,981...42,384,625
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G |
Il20rb |
interleukin 20 receptor subunit beta |
increases expression multiple interactions |
ISO |
Imiquimod results in increased expression of IL20RB mRNA ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL20RB mRNA] |
CTD |
PMID:31054998 |
|
NCBI chr 8:100,979,085...101,010,829
Ensembl chr 8:100,980,383...101,009,942
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G |
Il22ra1 |
interleukin 22 receptor subunit alpha 1 |
increases expression multiple interactions |
ISO |
Imiquimod results in increased expression of IL22RA1 mRNA ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL22RA1 mRNA] |
CTD |
PMID:31054998 |
|
NCBI chr 5:147,961,496...147,986,296
Ensembl chr 5:147,961,349...147,986,296
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G |
Il23a |
interleukin 23 subunit alpha |
increases secretion increases expression multiple interactions |
ISO |
imiquimod results in increased secretion of IL23A protein Imiquimod results in increased expression of IL23A mRNA; Imiquimod results in increased expression of IL23A protein ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL23A mRNA]; ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL23A protein] |
CTD |
PMID:25965695 PMID:26149470 PMID:31054998 |
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NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
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G |
Il27 |
interleukin 27 |
multiple interactions increases expression |
ISO |
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL27 mRNA] |
CTD |
PMID:31054998 |
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NCBI chr 1:181,173,108...181,178,720
Ensembl chr 1:181,173,372...181,178,582
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G |
Il33 |
interleukin 33 |
multiple interactions increases expression |
ISO |
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL33 mRNA] |
CTD |
PMID:31054998 |
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NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
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Il36a |
interleukin 36, alpha |
increases expression multiple interactions |
ISO |
Imiquimod results in increased expression of IL36A mRNA ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL36A mRNA] |
CTD |
PMID:31054998 |
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NCBI chr 3:6,996,851...7,001,400
Ensembl chr 3:6,996,851...7,001,400
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Il36b |
interleukin 36, beta |
increases expression multiple interactions |
ISO |
Imiquimod results in increased expression of IL36B mRNA ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL36B mRNA] |
CTD |
PMID:31054998 |
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NCBI chr 3:7,024,881...7,030,388
Ensembl chr 3:7,021,973...7,031,619
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G |
Il36g |
interleukin 36, gamma |
multiple interactions increases expression |
ISO |
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL36G mRNA] |
CTD |
PMID:31054998 |
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NCBI chr 3:6,948,323...6,954,485
Ensembl chr 3:6,948,297...6,954,480
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G |
Il36rn |
interleukin 36 receptor antagonist |
multiple interactions increases expression |
ISO |
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL36RN mRNA] |
CTD |
PMID:31054998 |
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NCBI chr 3:7,044,419...7,051,016
Ensembl chr 3:7,044,406...7,051,016
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G |
Il4 |
interleukin 4 |
increases secretion |
ISO |
Imiquimod results in increased secretion of IL4 protein |
CTD |
PMID:34740670 |
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NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Il6 |
interleukin 6 |
multiple interactions increases secretion |
ISO |
[Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased secretion of IL6 protein; concanamycin B inhibits the reaction [Imiquimod results in increased secretion of IL6 protein]; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased secretion of IL6 protein]; MV026630 inhibits the reaction [Imiquimod results in increased secretion of IL6 protein] [Hydroxychloroquine co-treated with Imiquimod] results in increased secretion of IL6 protein; Cannabidiol promotes the reaction [Imiquimod results in increased secretion of IL6 protein] |
CTD |
PMID:21097750 PMID:22916010 PMID:31082466 PMID:31093508 PMID:31383729 PMID:34740670 More...
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Il7 |
interleukin 7 |
increases expression multiple interactions |
ISO |
Imiquimod results in increased expression of IL7 mRNA ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL7 mRNA] |
CTD |
PMID:31054998 |
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NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075
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G |
Il7r |
interleukin 7 receptor |
multiple interactions increases expression |
ISO |
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL7R mRNA] |
CTD |
PMID:31054998 |
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NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757
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G |
Il9r |
interleukin 9 receptor |
decreases expression multiple interactions |
ISO |
Imiquimod results in decreased expression of IL9R mRNA ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL9R mRNA] |
CTD |
PMID:31054998 |
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NCBI chr10:15,431,706...15,444,144
Ensembl chr10:15,431,706...15,441,990
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G |
Irak2 |
interleukin-1 receptor-associated kinase 2 |
multiple interactions increases expression |
ISO |
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IRAK2 mRNA] |
CTD |
PMID:31054998 |
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NCBI chr 4:146,786,004...146,842,615
Ensembl chr 4:146,786,100...146,842,602
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G |
Irak3 |
interleukin-1 receptor-associated kinase 3 |
increases expression multiple interactions |
ISO |
Imiquimod results in increased expression of IRAK3 mRNA ferulic acid inhibits the reaction [Imiquimod results in increased expression of IRAK3 mRNA] |
CTD |
PMID:31054998 |
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NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121
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G |
Itgax |
integrin subunit alpha X |
multiple interactions |
ISO |
[imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ITGAX protein; Tetrachlorodibenzodioxin inhibits the reaction [[imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ITGAX protein] |
CTD |
PMID:21097750 |
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NCBI chr 1:182,709,653...182,740,709
Ensembl chr 1:182,719,609...182,740,698
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G |
Kif22 |
kinesin family member 22 |
decreases expression |
ISO |
imiquimod results in decreased expression of KIF22 mRNA |
CTD |
PMID:21878529 |
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NCBI chr 1:181,635,347...181,650,351
Ensembl chr 1:181,635,183...181,650,401
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G |
Lgmn |
legumain |
increases activity multiple interactions |
ISO |
Imiquimod results in increased activity of LGMN protein LGMN gene mutant form inhibits the reaction [Imiquimod results in increased cleavage of TLR7 protein]; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased expression of CD40 protein]; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased expression of CD86 protein]; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased secretion of IL12B protein]; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased secretion of IL6 protein] |
CTD |
PMID:22916010 |
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NCBI chr 6:121,544,048...121,582,495
Ensembl chr 6:121,544,053...121,582,480
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G |
Lig1 |
DNA ligase 1 |
decreases expression |
ISO |
imiquimod results in decreased expression of LIG1 mRNA |
CTD |
PMID:21878529 |
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NCBI chr 1:74,165,688...74,204,400
Ensembl chr 1:74,165,842...74,204,413
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G |
Lrch4 |
leucine rich repeats and calponin homology domain containing 4 |
multiple interactions |
ISO |
LRCH4 protein promotes the reaction [Imiquimod results in increased expression of TNF protein] |
CTD |
PMID:30523158 |
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NCBI chr12:19,057,582...19,072,573
Ensembl chr12:19,057,587...19,068,577
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G |
Mapk1 |
mitogen activated protein kinase 1 |
decreases phosphorylation |
ISO |
imiquimod results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:20033192 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
decreases phosphorylation |
ISO |
imiquimod results in decreased phosphorylation of MAPK3 protein |
CTD |
PMID:20033192 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mlh1 |
mutL homolog 1 |
decreases expression |
ISO |
imiquimod results in decreased expression of MLH1 mRNA |
CTD |
PMID:21878529 |
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NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617
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G |
Mmp9 |
matrix metallopeptidase 9 |
decreases activity |
ISO |
imiquimod results in decreased activity of MMP9 protein |
CTD |
PMID:14708627 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mpg |
N-methylpurine-DNA glycosylase |
decreases expression |
ISO |
imiquimod results in decreased expression of MPG mRNA |
CTD |
PMID:21878529 |
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NCBI chr10:15,396,246...15,402,528
Ensembl chr10:15,395,782...15,402,520
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G |
Mpo |
myeloperoxidase |
increases activity multiple interactions |
ISO |
imiquimod results in increased activity of MPO protein (+)-JQ1 compound inhibits the reaction [imiquimod results in increased activity of MPO protein]; SR 1078 inhibits the reaction [(+)-JQ1 compound inhibits the reaction [imiquimod results in increased activity of MPO protein]] |
CTD |
PMID:26149470 |
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NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Mre11 |
MRE11 homolog, double strand break repair nuclease |
decreases expression |
ISO |
imiquimod results in decreased expression of MRE11A mRNA |
CTD |
PMID:21878529 |
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NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279
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G |
Msh2 |
mutS homolog 2 |
decreases expression |
ISO |
imiquimod results in decreased expression of MSH2 mRNA |
CTD |
PMID:21878529 |
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NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938
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G |
Nudt1 |
nudix hydrolase 1 |
decreases expression |
ISO |
imiquimod results in decreased expression of NUDT1 mRNA |
CTD |
PMID:21878529 |
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NCBI chr12:14,302,514...14,309,559
Ensembl chr12:14,302,694...14,305,826
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G |
Pck1 |
phosphoenolpyruvate carboxykinase 1 |
multiple interactions |
ISO |
[resveratrol co-treated with imiquimod] results in increased expression of PCK1 mRNA |
CTD |
PMID:25965695 |
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NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
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G |
Pcna |
proliferating cell nuclear antigen |
increases expression multiple interactions |
ISO |
Imiquimod results in increased expression of PCNA protein Chloroquine inhibits the reaction [Imiquimod results in increased expression of PCNA protein] |
CTD |
PMID:36002070 |
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NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Pms2 |
PMS1 homolog 2, mismatch repair system component |
decreases expression |
ISO |
imiquimod results in decreased expression of PMS2 mRNA |
CTD |
PMID:21878529 |
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NCBI chr12:10,676,818...10,701,161
Ensembl chr12:10,676,764...10,701,066
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G |
Pole |
DNA polymerase epsilon, catalytic subunit |
decreases expression |
ISO |
imiquimod results in decreased expression of POLE mRNA |
CTD |
PMID:21878529 |
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NCBI chr12:46,345,420...46,393,984
Ensembl chr12:46,345,420...46,393,939
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G |
Poll |
DNA polymerase lambda |
decreases expression |
ISO |
imiquimod results in decreased expression of POLL mRNA |
CTD |
PMID:21878529 |
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NCBI chr 1:244,400,202...244,408,762
Ensembl chr 1:244,400,204...244,408,662
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G |
Ppp1r3c |
protein phosphatase 1, regulatory subunit 3C |
multiple interactions |
ISO |
[resveratrol co-treated with imiquimod] results in decreased expression of PPP1R3C mRNA |
CTD |
PMID:25965695 |
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NCBI chr 1:234,460,958...234,465,961
Ensembl chr 1:234,460,652...234,465,961
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G |
Rad51ap1 |
RAD51 associated protein 1 |
decreases expression |
ISO |
imiquimod results in decreased expression of RAD51AP1 mRNA |
CTD |
PMID:21878529 |
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NCBI chr 4:159,759,454...159,772,473
Ensembl chr 4:159,759,459...159,772,524
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G |
Rad51d |
RAD51 paralog D |
decreases expression |
ISO |
imiquimod results in decreased expression of RAD51D mRNA |
CTD |
PMID:21878529 |
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NCBI chr10:67,805,720...67,824,452
Ensembl chr10:67,740,712...67,824,434
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G |
Rad54l |
RAD54 like |
decreases expression |
ISO |
imiquimod results in decreased expression of RAD54L mRNA |
CTD |
PMID:21878529 |
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NCBI chr 5:129,575,431...129,605,100
Ensembl chr 5:129,575,378...129,605,070
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G |
Rorc |
RAR-related orphan receptor C |
increases expression multiple interactions |
ISO |
imiquimod results in increased expression of RORC mRNA; imiquimod results in increased expression of RORC protein (+)-JQ1 compound inhibits the reaction [imiquimod results in increased expression of RORC mRNA]; (+)-JQ1 compound inhibits the reaction [imiquimod results in increased expression of RORC protein] |
CTD |
PMID:26149470 |
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NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907
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G |
Ruvbl2 |
RuvB-like AAA ATPase 2 |
decreases expression |
ISO |
imiquimod results in decreased expression of RUVBL2 mRNA |
CTD |
PMID:21878529 |
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NCBI chr 1:95,902,014...95,915,247
Ensembl chr 1:95,901,701...95,915,342
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G |
Slc47a1 |
solute carrier family 47 member 1 |
multiple interactions |
ISO |
imiquimod inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:22419765 |
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NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
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G |
Slc47a2 |
solute carrier family 47 member 2 |
multiple interactions |
ISO |
imiquimod inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:22419765 |
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NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
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G |
Ssrp1 |
structure specific recognition protein 1 |
decreases expression |
ISO |
imiquimod results in decreased expression of SSRP1 mRNA |
CTD |
PMID:21878529 |
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NCBI chr 3:70,124,371...70,134,481
Ensembl chr 3:70,118,655...70,134,482
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G |
Stat3 |
signal transducer and activator of transcription 3 |
increases expression |
ISO |
imiquimod results in increased expression of STAT3 mRNA |
CTD |
PMID:26149470 |
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NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Tgfb1 |
transforming growth factor, beta 1 |
increases secretion |
ISO |
Imiquimod results in increased secretion of TGFB1 protein |
CTD |
PMID:34740670 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
increases expression |
ISO |
imiquimod results in increased expression of TIMP1 protein |
CTD |
PMID:14708627 |
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NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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G |
Tlr7 |
toll-like receptor 7 |
multiple interactions affects binding increases cleavage |
ISO |
[Imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]; [Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of CD86 protein; [Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ICAM1 protein; [Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ITGAX protein; [Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased secretion of IL6 protein; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased cleavage of TLR7 protein]; Tetrachlorodibenzodioxin inhibits the reaction [[Imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]]; Tetrachlorodibenzodioxin inhibits the reaction [[Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ITGAX protein]; Tetrachlorodibenzodioxin promotes the reaction [[Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of CD86 protein]; Tetrachlorodibenzodioxin promotes the reaction [[Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ICAM1 protein] Imiquimod binds to TLR7 protein |
CTD |
PMID:21097750 PMID:22916010 PMID:31093508 |
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NCBI chr X:27,027,380...27,054,309
Ensembl chr X:27,027,425...27,054,754
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G |
Tnf |
tumor necrosis factor |
multiple interactions increases expression increases secretion |
ISO |
CGP 57380 inhibits the reaction [Imiquimod results in increased expression of TNF protein]; LRCH4 protein promotes the reaction [Imiquimod results in increased expression of TNF protein] Imiquimod results in increased expression of TNF mRNA; Imiquimod results in increased expression of TNF protein Imiquimod results in increased secretion of TNF protein Cannabidiol promotes the reaction [Imiquimod results in increased secretion of TNF protein] |
CTD |
PMID:18032482 PMID:25965695 PMID:26149470 PMID:30523158 PMID:31093508 PMID:34740670 More...
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Trex1 |
three prime repair exonuclease 1 |
increases expression |
ISO |
imiquimod results in increased expression of TREX1 mRNA |
CTD |
PMID:21878529 |
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NCBI chr 8:109,706,613...109,707,913
Ensembl chr 8:109,706,613...109,708,796
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G |
Trim63 |
tripartite motif containing 63 |
multiple interactions |
ISO |
[resveratrol co-treated with imiquimod] results in increased expression of TRIM63 mRNA |
CTD |
PMID:25965695 |
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NCBI chr 5:146,533,492...146,547,332
Ensembl chr 5:146,533,507...146,547,322
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G |
Uhrf1 |
ubiquitin-like with PHD and ring finger domains 1 |
decreases expression |
ISO |
imiquimod results in decreased expression of UHRF1 mRNA |
CTD |
PMID:21878529 |
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NCBI chr 9:1,133,117...1,154,639
Ensembl chr 9:1,134,909...1,154,631
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G |
Wrnip1 |
WRN helicase interacting protein 1 |
decreases expression |
ISO |
imiquimod results in decreased expression of WRNIP1 mRNA |
CTD |
PMID:21878529 |
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NCBI chr17:31,621,410...31,641,659
Ensembl chr17:31,621,411...31,641,659
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G |
Xpc |
XPC complex subunit, DNA damage recognition and repair factor |
increases expression |
ISO |
imiquimod results in increased expression of XPC mRNA |
CTD |
PMID:21878529 |
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NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010
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