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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:imiquimod
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Accession:CHEBI:36704 term browser browse the term
Definition:An imidazoquinoline fused [4,5-c] carrying isobutyl and amino substituents at N-1 and C-4 respectively. A prescription medication, it acts as an immune response modifier and is used to treat genital warts, superficial basal cell carcinoma, and actinic keratosis.
Synonyms:exact_synonym: 1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine
 related_synonym: 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine;   4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline;   Formula=C14H16N4;   InChI=1S/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17);   InChIKey=DOUYETYNHWVLEO-UHFFFAOYSA-N;   R 837;   SMILES=C1=2C=CC=CC2N=C(C=3N=CN(C13)CC(C)C)N;   imiquimodum
 xref: Beilstein:7710060;   CAS:99011-02-6;   DrugBank:DB00724;   Drug_Central:1429;   LINCS:LSM-5408
 xref_mesh: MESH:C056493
 xref: PMID:10861101;   PMID:15868314;   PMID:16217984;   PMID:18424373;   PMID:27548435;   PMID:28872561;   PMID:29422777;   PMID:29485187;   PMID:29505317;   PMID:29596875;   Patent:AU2005320890;   Patent:EP1831219;   Patent:KR20070102652;   Reaxys:7710060;   Wikipedia:Imiquimod

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imiquimod term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation		 ISO epigallocatechin gallate inhibits the reaction [Imiquimod results in increased phosphorylation of AKT1 protein] CTD PMID:24990399 PMID:29402411 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 decreases expression ISO imiquimod results in decreased expression of APEX1 mRNA CTD PMID:21878529 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO imiquimod results in decreased expression of BCL2 protein CTD PMID:20033192 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Blm BLM RecQ like helicase decreases expression ISO imiquimod results in decreased expression of BLM mRNA CTD PMID:21878529 NCBI chr 1:142,246,773...142,332,616
Ensembl chr 1:142,246,790...142,332,588 		JBrowse link
G Brca2 BRCA2, DNA repair associated decreases expression ISO imiquimod results in decreased expression of BRCA2 mRNA CTD PMID:21878529 NCBI chr12:503,660...544,754
Ensembl chr12:504,007...544,748 		JBrowse link
G Bst2 bone marrow stromal cell antigen 2 increases expression ISO Imiquimod results in increased expression of BST2 protein CTD PMID:31093508 NCBI chr16:19,938,781...19,942,353
Ensembl chr16:19,938,784...19,942,353 		JBrowse link
G Casp1 caspase 1 increases activity
multiple interactions		 ISO Imiquimod results in increased activity of CASP1 protein
[Dronabinol inhibits the reaction [Imiquimod results in increased activity of CASP1 protein]] which affects the localization of IL1B protein; Dronabinol inhibits the reaction [Imiquimod results in increased activity of CASP1 protein]		 CTD PMID:31383729 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631 		JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage		 ISO imiquimod results in increased activity of CASP3 protein
imiquimod results in increased cleavage of CASP3 protein		 CTD PMID:12902443 PMID:20033192 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cd274 CD274 molecule increases expression ISO Imiquimod results in increased expression of CD274 protein CTD PMID:31093508 NCBI chr 1:247,519,890...247,539,659
Ensembl chr 1:247,519,939...247,537,943 		JBrowse link
G Cd40 CD40 molecule increases expression
multiple interactions		 ISO Imiquimod results in increased expression of CD40 protein
LGMN gene mutant form inhibits the reaction [Imiquimod results in increased expression of CD40 protein]		 CTD PMID:22916010 PMID:31093508 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704 		JBrowse link
G Cd80 Cd80 molecule increases expression ISO Imiquimod results in increased expression of CD80 protein CTD PMID:31093508 NCBI chr11:64,815,201...64,855,293
Ensembl chr11:64,827,635...64,855,353 		JBrowse link
G Cd86 CD86 molecule multiple interactions
increases expression		 ISO [Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of CD86 protein; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased expression of CD86 protein]; Tetrachlorodibenzodioxin promotes the reaction [[Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of CD86 protein] CTD PMID:21097750 PMID:22916010 PMID:31093508 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795 		JBrowse link
G Chaf1a chromatin assembly factor 1 subunit A decreases expression ISO imiquimod results in decreased expression of CHAF1A mRNA CTD PMID:21878529 NCBI chr 9:11,000,869...11,027,631
Ensembl chr 9:11,001,129...11,027,506 		JBrowse link
G Chaf1b chromatin assembly factor 1 subunit B decreases expression ISO imiquimod results in decreased expression of CHAF1B mRNA CTD PMID:21878529 NCBI chr11:34,101,248...34,121,371
Ensembl chr11:34,101,197...34,121,378 		JBrowse link
G Ctsb cathepsin B increases activity ISO Imiquimod results in increased activity of CTSB protein CTD PMID:22916010 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612 		JBrowse link
G Ctsk cathepsin K increases activity ISO Imiquimod results in increased activity of CTSK protein CTD PMID:22916010 NCBI chr 2:196,655,469...196,666,447
Ensembl chr 2:196,655,469...196,666,446 		JBrowse link
G Ctsl cathepsin L increases activity ISO Imiquimod results in increased activity of CTSL protein CTD PMID:22916010 NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279 		JBrowse link
G Ctss cathepsin S increases activity ISO Imiquimod results in increased activity of CTSS protein CTD PMID:22916010 NCBI chr 2:197,655,780...197,679,768
Ensembl chr 2:197,655,786...197,679,458 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO [Pam(3)CSK(4) peptide co-treated with Antigens, Bacterial co-treated with Poly I-C co-treated with Lipopolysaccharides co-treated with FSL-1 lipoprotein, synthetic co-treated with imiquimod co-treated with Polyribonucleotides co-treated with ProMune] results in increased expression of CXCL10 protein; Particulate Matter inhibits the reaction [[Pam(3)CSK(4) peptide co-treated with Antigens, Bacterial co-treated with Poly I-C co-treated with Lipopolysaccharides co-treated with FSL-1 lipoprotein, synthetic co-treated with imiquimod co-treated with Polyribonucleotides co-treated with ProMune] results in increased expression of CXCL10 protein]; Vehicle Emissions inhibits the reaction [[Pam(3)CSK(4) peptide co-treated with Antigens, Bacterial co-treated with Poly I-C co-treated with Lipopolysaccharides co-treated with FSL-1 lipoprotein, synthetic co-treated with imiquimod co-treated with Polyribonucleotides co-treated with ProMune] results in increased expression of CXCL10 protein] CTD PMID:28655636 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases secretion ISO Imiquimod results in increased secretion of CXCL1 protein CTD PMID:22916010 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing
multiple interactions
affects metabolic processing
increases chemical synthesis		 ISO CYP1A1 protein results in increased metabolism of Imiquimod
CYP1A1 protein affects the reaction [beta-Naphthoflavone results in increased metabolism of Imiquimod]
CYP1A1 protein affects the metabolism of Imiquimod
[CYP1A1 protein results in increased metabolism of Imiquimod] which results in increased chemical synthesis of Imiquimod metabolite
CYP1A1 protein results in increased chemical synthesis of Imiquimod metabolite		 CTD PMID:31111189 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
affects metabolic processing
increases chemical synthesis
increases metabolic processing		 ISO [CYP1A2 protein results in increased metabolism of Imiquimod] which results in increased chemical synthesis of Imiquimod metabolite
CYP1A2 protein affects the metabolism of Imiquimod
CYP1A2 protein results in increased chemical synthesis of Imiquimod metabolite
CYP1A2 protein affects the reaction [beta-Naphthoflavone results in increased metabolism of Imiquimod]		 CTD PMID:31111189 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases metabolic processing ISO CYP2C19 protein results in increased metabolism of Imiquimod CTD PMID:31111189 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing ISO CYP2D6 protein results in increased metabolism of Imiquimod CTD PMID:31111189 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436 		JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit decreases expression ISO imiquimod results in decreased expression of ERCC2 mRNA CTD PMID:21878529 NCBI chr 1:80,293,574...80,307,334
Ensembl chr 1:80,293,566...80,307,344 		JBrowse link
G Ercc5 ERCC excision repair 5, endonuclease increases expression ISO imiquimod results in increased expression of ERCC5 mRNA CTD PMID:21878529 NCBI chr 9:50,928,847...50,970,962
Ensembl chr 9:50,925,619...50,970,955 		JBrowse link
G Fancl FA complementation group L decreases expression ISO imiquimod results in decreased expression of FANCL mRNA CTD PMID:21878529 NCBI chr14:110,675,306...110,740,880
Ensembl chr14:110,676,090...110,740,317 		JBrowse link
G Fbh1 F-box DNA helicase 1 decreases expression ISO imiquimod results in decreased expression of FBH1 mRNA CTD PMID:21878529 NCBI chr17:70,399,093...70,437,151
Ensembl chr17:70,399,049...70,437,144 		JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression ISO imiquimod results in decreased expression of FGF2 CTD PMID:16368197 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681 		JBrowse link
G Gtf2h3 general transcription factor IIH subunit 3 decreases expression ISO imiquimod results in decreased expression of GTF2H3 mRNA CTD PMID:21878529 NCBI chr12:37,427,556...37,444,027
Ensembl chr12:37,427,546...37,444,282 		JBrowse link
G Gtf2h4 general transcription factor 2H subunit 4 decreases expression ISO imiquimod results in decreased expression of GTF2H4 mRNA CTD PMID:21878529 NCBI chr20:3,582,688...3,588,373
Ensembl chr20:3,582,742...3,588,375 		JBrowse link
G Gzmb granzyme B multiple interactions ISO Imiquimod results in increased expression of and results in increased secretion of GZMB protein CTD PMID:31093508 NCBI chr15:35,413,862...35,417,293
Ensembl chr15:35,413,793...35,417,316 		JBrowse link
G H2ax H2A.X variant histone decreases expression ISO Imiquimod results in decreased expression of H2AX mRNA CTD PMID:21878529 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO [imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ICAM1 protein; Tetrachlorodibenzodioxin promotes the reaction [[imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ICAM1 protein] CTD PMID:21097750 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Hydroxychloroquine co-treated with Imiquimod] results in increased secretion of IL10 protein CTD PMID:31082466 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il11 interleukin 11 multiple interactions
decreases expression		 ISO ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL11 mRNA] CTD PMID:31054998 NCBI chr 1:72,636,959...72,643,255
Ensembl chr 1:72,635,267...72,643,255 		JBrowse link
G Il11ra1 interleukin 11 receptor subunit alpha 1 multiple interactions
decreases expression		 ISO ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL11RA1 mRNA] CTD PMID:31054998 NCBI chr 5:58,149,150...58,159,072
Ensembl chr 5:58,151,985...58,159,072 		JBrowse link
G Il12a interleukin 12A multiple interactions
increases secretion		 ISO [imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]; Tetrachlorodibenzodioxin inhibits the reaction [[imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]]
Imiquimod results in increased secretion of IL12A protein		 CTD PMID:21097750 PMID:31093508 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318 		JBrowse link
G Il12b interleukin 12B multiple interactions
increases secretion
increases expression		 ISO [Imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]; ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL12B mRNA]; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased secretion of IL12B protein]; Tetrachlorodibenzodioxin inhibits the reaction [[Imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]] CTD PMID:21097750 PMID:22916010 PMID:31054998 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085 		JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 multiple interactions
increases expression		 ISO ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL13RA1 mRNA] CTD PMID:31054998 NCBI chr  X:122,724,081...122,783,801
Ensembl chr  X:122,724,129...122,781,479 		JBrowse link
G Il13ra2 interleukin 13 receptor subunit alpha 2 increases expression ISO Imiquimod results in increased expression of IL13RA2 mRNA CTD PMID:31054998 NCBI chr  X:118,443,955...118,514,716
Ensembl chr  X:118,443,823...118,513,061 		JBrowse link
G Il17a interleukin 17A multiple interactions
increases expression
increases secretion		 ISO (+)-JQ1 compound inhibits the reaction [Imiquimod results in increased expression of IL17A mRNA]; (+)-JQ1 compound inhibits the reaction [Imiquimod results in increased secretion of IL17A protein]; ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL17A mRNA]; ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL17A protein]; Resveratrol inhibits the reaction [Imiquimod results in increased expression of IL17A mRNA]; SR 1078 inhibits the reaction [(+)-JQ1 compound inhibits the reaction [Imiquimod results in increased expression of IL17A mRNA]]; SR 1078 inhibits the reaction [(+)-JQ1 compound inhibits the reaction [Imiquimod results in increased secretion of IL17A protein]]
Imiquimod results in increased expression of IL17A mRNA; Imiquimod results in increased expression of IL17A protein
imiquimod results in increased secretion of IL17A protein		 CTD PMID:25965695 PMID:26149470 PMID:31054998 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786 		JBrowse link
G Il17b interleukin 17B decreases expression
multiple interactions		 ISO Imiquimod results in decreased expression of IL17B mRNA
ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL17B mRNA]		 CTD PMID:31054998 NCBI chr18:57,011,575...57,016,009
Ensembl chr18:57,011,575...57,016,009 		JBrowse link
G Il17rb interleukin 17 receptor B decreases expression
multiple interactions		 ISO Imiquimod results in decreased expression of IL17RB mRNA
ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL17RB mRNA]		 CTD PMID:31054998 NCBI chr16:6,064,287...6,077,978
Ensembl chr16:6,064,288...6,077,978 		JBrowse link
G Il18 interleukin 18 increases expression
multiple interactions		 ISO Imiquimod results in increased expression of IL18 mRNA
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL18 mRNA]		 CTD PMID:31054998 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299 		JBrowse link
G Il18rap interleukin 18 receptor accessory protein multiple interactions
increases expression		 ISO ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL18RAP mRNA] CTD PMID:31054998 NCBI chr 9:47,225,543...47,255,805
Ensembl chr 9:47,225,585...47,258,503 		JBrowse link
G Il19 interleukin 19 increases expression
multiple interactions		 ISO imiquimod results in increased expression of IL19 mRNA
resveratrol inhibits the reaction [imiquimod results in increased expression of IL19 mRNA]		 CTD PMID:25965695 NCBI chr13:47,663,592...47,677,869
Ensembl chr13:47,664,080...47,670,407 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions
increases expression		 ISO ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL1A mRNA] CTD PMID:31054998 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086 		JBrowse link
G Il1b interleukin 1 beta increases secretion
multiple interactions
increases expression		 ISO Imiquimod results in increased secretion of IL1B protein
[Dronabinol inhibits the reaction [Imiquimod results in increased activity of CASP1 protein]] which affects the localization of IL1B protein; Dronabinol inhibits the reaction [Imiquimod results in increased expression of IL1B mRNA]; Dronabinol inhibits the reaction [Imiquimod results in increased secretion of IL1B protein]; JHW 015 inhibits the reaction [Imiquimod results in increased secretion of IL1B protein]
Imiquimod results in increased expression of IL1B mRNA; Imiquimod results in increased expression of IL1B protein
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL1B mRNA]; ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL1B protein]		 CTD PMID:18403674 PMID:31054998 PMID:31082466 PMID:31383729 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il1f10 interleukin 1 family member 10 decreases expression
multiple interactions		 ISO Imiquimod results in decreased expression of IL1F10 mRNA
ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL1F10 mRNA]		 CTD PMID:31054998 NCBI chr 3:1,408,560...1,416,601
Ensembl chr 3:1,413,671...1,416,599 		JBrowse link
G Il1rap interleukin 1 receptor accessory protein increases expression ISO Imiquimod results in increased expression of IL1RAP mRNA CTD PMID:31054998 NCBI chr11:77,456,648...77,593,208
Ensembl chr11:77,463,954...77,593,207 		JBrowse link
G Il20 interleukin 20 increases expression
multiple interactions		 ISO Imiquimod results in increased expression of IL20 mRNA
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL20 mRNA]		 CTD PMID:31054998 NCBI chr13:47,644,071...47,651,487
Ensembl chr13:47,644,071...47,647,715 		JBrowse link
G Il20rb interleukin 20 receptor subunit beta increases expression
multiple interactions		 ISO Imiquimod results in increased expression of IL20RB mRNA
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL20RB mRNA]		 CTD PMID:31054998 NCBI chr 8:108,745,906...108,778,561
Ensembl chr 8:108,747,204...108,777,717 		JBrowse link
G Il22ra1 interleukin 22 receptor subunit alpha 1 increases expression
multiple interactions		 ISO Imiquimod results in increased expression of IL22RA1 mRNA
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL22RA1 mRNA]		 CTD PMID:31054998 NCBI chr 5:154,078,093...154,102,903
Ensembl chr 5:154,077,944...154,106,433 		JBrowse link
G Il23a interleukin 23 subunit alpha increases secretion
multiple interactions
increases expression		 ISO imiquimod results in increased secretion of IL23A protein
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL23A mRNA]; ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL23A protein]
Imiquimod results in increased expression of IL23A mRNA; Imiquimod results in increased expression of IL23A protein		 CTD PMID:25965695 PMID:26149470 PMID:31054998 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723 		JBrowse link
G Il27 interleukin 27 multiple interactions
increases expression		 ISO ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL27 mRNA] CTD PMID:31054998 NCBI chr 1:198,003,615...198,010,112
Ensembl chr 1:198,003,683...198,008,893 		JBrowse link
G Il33 interleukin 33 multiple interactions
increases expression		 ISO ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL33 mRNA] CTD PMID:31054998 NCBI chr 1:248,112,611...248,147,030
Ensembl chr 1:248,132,090...248,147,029 		JBrowse link
G Il36a interleukin 36, alpha increases expression
multiple interactions		 ISO Imiquimod results in increased expression of IL36A mRNA
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL36A mRNA]		 CTD PMID:31054998 NCBI chr 3:1,330,790...1,335,811
Ensembl chr 3:1,331,226...1,335,775 		JBrowse link
G Il36b interleukin 36, beta increases expression
multiple interactions		 ISO Imiquimod results in increased expression of IL36B mRNA
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL36B mRNA]		 CTD PMID:31054998 NCBI chr 3:1,366,123...1,464,851
Ensembl chr 3:1,366,119...1,371,626 		JBrowse link
G Il36g interleukin 36, gamma multiple interactions
increases expression		 ISO ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL36G mRNA] CTD PMID:31054998 NCBI chr 3:1,285,658...1,291,836
Ensembl chr 3:1,285,664...1,291,865 		JBrowse link
G Il36rn interleukin 36 receptor antagonist multiple interactions
increases expression		 ISO ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL36RN mRNA] CTD PMID:31054998 NCBI chr 3:1,385,256...1,392,275
Ensembl chr 3:1,385,654...1,392,275 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases secretion		 ISO [Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased secretion of IL6 protein; concanamycin B inhibits the reaction [Imiquimod results in increased secretion of IL6 protein]; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased secretion of IL6 protein]; MV026630 inhibits the reaction [Imiquimod results in increased secretion of IL6 protein]
[Hydroxychloroquine co-treated with Imiquimod] results in increased secretion of IL6 protein		 CTD PMID:21097750 PMID:22916010 PMID:31082466 PMID:31093508 PMID:31383729 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Il7 interleukin 7 increases expression
multiple interactions		 ISO Imiquimod results in increased expression of IL7 mRNA
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL7 mRNA]		 CTD PMID:31054998 NCBI chr 2:96,427,884...96,474,979
Ensembl chr 2:96,439,286...96,474,977 		JBrowse link
G Il7r interleukin 7 receptor multiple interactions
increases expression		 ISO ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL7R mRNA] CTD PMID:31054998
G Il9r interleukin 9 receptor decreases expression
multiple interactions		 ISO Imiquimod results in decreased expression of IL9R mRNA
ferulic acid inhibits the reaction [Imiquimod results in decreased expression of IL9R mRNA]		 CTD PMID:31054998 NCBI chr10:15,697,216...15,708,684
Ensembl chr10:15,696,824...15,710,423 		JBrowse link
G Irak2 interleukin-1 receptor-associated kinase 2 multiple interactions
increases expression		 ISO ferulic acid inhibits the reaction [Imiquimod results in increased expression of IRAK2 mRNA] CTD PMID:31054998 NCBI chr 4:145,594,575...145,651,066
Ensembl chr 4:145,594,575...145,651,053 		JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 increases expression
multiple interactions		 ISO Imiquimod results in increased expression of IRAK3 mRNA
ferulic acid inhibits the reaction [Imiquimod results in increased expression of IRAK3 mRNA]		 CTD PMID:31054998 NCBI chr 7:64,922,830...64,982,224
Ensembl chr 7:64,923,615...64,982,281 		JBrowse link
G Itgax integrin subunit alpha X multiple interactions ISO [imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ITGAX protein; Tetrachlorodibenzodioxin inhibits the reaction [[imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ITGAX protein] CTD PMID:21097750 NCBI chr 1:199,555,560...199,576,948
Ensembl chr 1:199,555,722...199,576,932 		JBrowse link
G Kif22 kinesin family member 22 decreases expression ISO imiquimod results in decreased expression of KIF22 mRNA CTD PMID:21878529 NCBI chr 1:198,461,406...198,476,430
Ensembl chr 1:198,461,169...198,476,476 		JBrowse link
G Lgmn legumain increases activity
multiple interactions		 ISO Imiquimod results in increased activity of LGMN protein
LGMN gene mutant form inhibits the reaction [Imiquimod results in increased cleavage of TLR7 protein]; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased expression of CD40 protein]; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased expression of CD86 protein]; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased secretion of IL12B protein]; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased secretion of IL6 protein]		 CTD PMID:22916010 NCBI chr 6:126,282,246...126,308,207
Ensembl chr 6:126,282,233...126,320,726 		JBrowse link
G Lig1 DNA ligase 1 decreases expression ISO imiquimod results in decreased expression of LIG1 mRNA CTD PMID:21878529 NCBI chr 1:75,356,212...75,394,757
Ensembl chr 1:75,356,220...75,394,758 		JBrowse link
G Lrch4 leucine rich repeats and calponin homology domain containing 4 multiple interactions ISO LRCH4 protein promotes the reaction [Imiquimod results in increased expression of TNF protein] CTD PMID:30523158 NCBI chr12:22,127,387...22,138,436
Ensembl chr12:22,127,393...22,138,382 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO imiquimod results in decreased phosphorylation of MAPK1 protein CTD PMID:20033192 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO imiquimod results in decreased phosphorylation of MAPK3 protein CTD PMID:20033192 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mlh1 mutL homolog 1 decreases expression ISO imiquimod results in decreased expression of MLH1 mRNA CTD PMID:21878529 NCBI chr 8:119,486,655...119,523,716
Ensembl chr 8:119,486,691...119,523,964 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases activity ISO imiquimod results in decreased activity of MMP9 protein CTD PMID:14708627 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Mpg N-methylpurine-DNA glycosylase decreases expression ISO imiquimod results in decreased expression of MPG mRNA CTD PMID:21878529 NCBI chr10:15,661,768...15,667,995
Ensembl chr10:15,661,608...15,668,022 		JBrowse link
G Mpo myeloperoxidase increases activity
multiple interactions		 ISO imiquimod results in increased activity of MPO protein
(+)-JQ1 compound inhibits the reaction [imiquimod results in increased activity of MPO protein]; SR 1078 inhibits the reaction [(+)-JQ1 compound inhibits the reaction [imiquimod results in increased activity of MPO protein]]		 CTD PMID:26149470 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260 		JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease decreases expression ISO imiquimod results in decreased expression of MRE11A mRNA CTD PMID:21878529 NCBI chr 8:13,304,355...13,350,329
Ensembl chr 8:13,305,152...13,352,489 		JBrowse link
G Msh2 mutS homolog 2 decreases expression ISO imiquimod results in decreased expression of MSH2 mRNA CTD PMID:21878529 NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932 		JBrowse link
G Nudt1 nudix hydrolase 1 decreases expression ISO imiquimod results in decreased expression of NUDT1 mRNA CTD PMID:21878529 NCBI chr12:16,391,578...16,398,771
Ensembl chr12:16,391,578...16,395,029 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions ISO [resveratrol co-treated with imiquimod] results in increased expression of PCK1 mRNA CTD PMID:25965695 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component decreases expression ISO imiquimod results in decreased expression of PMS2 mRNA CTD PMID:21878529 NCBI chr12:12,714,394...12,738,654
Ensembl chr12:12,714,394...12,738,641 		JBrowse link
G Pole DNA polymerase epsilon, catalytic subunit decreases expression ISO imiquimod results in decreased expression of POLE mRNA CTD PMID:21878529 NCBI chr12:52,403,533...52,452,075
Ensembl chr12:52,403,529...52,452,040 		JBrowse link
G Poll DNA polymerase lambda decreases expression ISO imiquimod results in decreased expression of POLL mRNA CTD PMID:21878529 NCBI chr 1:265,290,337...265,298,847
Ensembl chr 1:265,290,339...265,298,797 		JBrowse link
G Ppp1r3c protein phosphatase 1, regulatory subunit 3C multiple interactions ISO [resveratrol co-treated with imiquimod] results in decreased expression of PPP1R3C mRNA CTD PMID:25965695 NCBI chr 1:255,371,830...255,376,833
Ensembl chr 1:255,371,810...255,376,833 		JBrowse link
G Rad51ap1 RAD51 associated protein 1 decreases expression ISO imiquimod results in decreased expression of RAD51AP1 mRNA CTD PMID:21878529 NCBI chr 4:159,469,803...159,482,869
Ensembl chr 4:159,469,804...159,482,869 		JBrowse link
G Rad51d RAD51 paralog D decreases expression ISO imiquimod results in decreased expression of RAD51D mRNA CTD PMID:21878529 NCBI chr10:70,222,703...70,241,352
Ensembl chr10:70,227,163...70,241,254 		JBrowse link
G Rad54l RAD54 like decreases expression ISO imiquimod results in decreased expression of RAD54L mRNA CTD PMID:21878529 NCBI chr 5:134,948,511...134,978,125
Ensembl chr 5:134,948,512...134,978,125 		JBrowse link
G Rorc RAR-related orphan receptor C increases expression
multiple interactions		 ISO imiquimod results in increased expression of RORC mRNA; imiquimod results in increased expression of RORC protein
(+)-JQ1 compound inhibits the reaction [imiquimod results in increased expression of RORC mRNA]; (+)-JQ1 compound inhibits the reaction [imiquimod results in increased expression of RORC protein]		 CTD PMID:26149470 NCBI chr 2:195,612,471...195,636,797
Ensembl chr 2:195,617,021...195,637,630 		JBrowse link
G Ruvbl2 RuvB-like AAA ATPase 2 decreases expression ISO imiquimod results in decreased expression of RUVBL2 mRNA CTD PMID:21878529 NCBI chr 1:101,413,766...101,426,970
Ensembl chr 1:101,413,766...101,426,852 		JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO imiquimod inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO imiquimod inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,587,909...47,631,373
Ensembl chr10:47,588,497...47,630,799 		JBrowse link
G Ssrp1 structure specific recognition protein 1 decreases expression ISO imiquimod results in decreased expression of SSRP1 mRNA CTD PMID:21878529 NCBI chr 3:72,447,516...72,457,621
Ensembl chr 3:72,447,537...72,457,649 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression ISO imiquimod results in increased expression of STAT3 mRNA CTD PMID:26149470 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO imiquimod results in increased expression of TIMP1 protein CTD PMID:14708627 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384 		JBrowse link
G Tlr7 toll-like receptor 7 multiple interactions
increases cleavage
affects binding		 ISO [Imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]; [Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of CD86 protein; [Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ICAM1 protein; [Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ITGAX protein; [Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased secretion of IL6 protein; LGMN gene mutant form inhibits the reaction [Imiquimod results in increased cleavage of TLR7 protein]; Tetrachlorodibenzodioxin inhibits the reaction [[Imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]]; Tetrachlorodibenzodioxin inhibits the reaction [[Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ITGAX protein]; Tetrachlorodibenzodioxin promotes the reaction [[Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of CD86 protein]; Tetrachlorodibenzodioxin promotes the reaction [[Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ICAM1 protein]
Imiquimod binds to TLR7 protein		 CTD PMID:21097750 PMID:22916010 PMID:31093508 NCBI chr  X:28,486,836...28,513,004
Ensembl chr  X:28,486,869...28,512,957 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
increases expression		 ISO CGP 57380 inhibits the reaction [Imiquimod results in increased expression of TNF protein]; LRCH4 protein promotes the reaction [Imiquimod results in increased expression of TNF protein]
Imiquimod results in increased secretion of TNF protein
Imiquimod results in increased expression of TNF mRNA; Imiquimod results in increased expression of TNF protein		 CTD PMID:18032482 PMID:25965695 PMID:26149470 PMID:30523158 PMID:31093508 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Trex1 three prime repair exonuclease 1 increases expression ISO imiquimod results in increased expression of TREX1 mRNA CTD PMID:21878529 NCBI chr 8:117,796,127...117,797,427
Ensembl chr 8:117,796,128...117,797,427 		JBrowse link
G Trim63 tripartite motif containing 63 multiple interactions ISO [resveratrol co-treated with imiquimod] results in increased expression of TRIM63 mRNA CTD PMID:25965695 NCBI chr 5:152,533,362...152,547,138
Ensembl chr 5:152,533,349...152,547,179 		JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 decreases expression ISO imiquimod results in decreased expression of UHRF1 mRNA CTD PMID:21878529 NCBI chr 9:10,738,211...10,758,403
Ensembl chr 9:10,738,222...10,757,954 		JBrowse link
G Wrnip1 WRN helicase interacting protein 1 decreases expression ISO imiquimod results in decreased expression of WRNIP1 mRNA CTD PMID:21878529 NCBI chr17:32,933,395...32,953,641
Ensembl chr17:32,933,396...32,953,641 		JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor increases expression ISO imiquimod results in increased expression of XPC mRNA CTD PMID:21878529 NCBI chr 4:123,134,457...123,161,985
Ensembl chr 4:123,134,457...123,161,985 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19883
    role 19833
      application 19505
        pharmaceutical 19375
          drug 19375
            antineoplastic agent 17034
              imiquimod 103
Path 2
Term Annotations click to browse term
  CHEBI ontology 19883
    subatomic particle 19881
      composite particle 19881
        hadron 19881
          baryon 19881
            nucleon 19881
              atomic nucleus 19881
                atom 19881
                  main group element atom 19771
                    p-block element atom 19771
                      carbon group element atom 19679
                        carbon atom 19668
                          organic molecular entity 19668
                            organic molecule 19596
                              organic cyclic compound 19407
                                organic heterocyclic compound 18517
                                  organic heteropolycyclic compound 17907
                                    organic heterotricyclic compound 14607
                                      imidazoquinoline 167
                                        imiquimod 103
paths to the root