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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tetrachloro-1,4-benzoquinone
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Accession:CHEBI:36703 term browser browse the term
Definition:A member of the class of 1,4-benzoquiones that is 1,4-benzoquinone in which all four hydrogens are substituted by chlorines.
Synonyms:exact_synonym: 2,3,5,6-tetrachlorocyclohexa-2,5-diene-1,4-dione
 related_synonym: 2,3,5,6-Tetrachlor-1,4-benzochinon;   2,3,5,6-tetrachloro-1,4-benzoquinone;   2,3,5,6-tetrachloro-2,5-cyclohexadiene-1,4-dione;   2,3,5,6-tetrachloro-p-benzoquinone;   2,3,5,6-tetrachlorobenzo-1,4-quinone;   Formula=C6Cl4O2;   InChI=1S/C6Cl4O2/c7-1-2(8)6(12)4(10)3(9)5(1)11;   InChIKey=UGNWTBMOAKPKBL-UHFFFAOYSA-N;   SMILES=ClC1=C(Cl)C(=O)C(Cl)=C(Cl)C1=O;   alpha-chloranil;   chloranil;   p-Chloranil;   tetrachloro-p-benzoquinone;   tetrachlorobenzoquinone;   tetrachloroparabenzoquinone
 xref: Beilstein:393006;   CAS:118-75-2;   Gmelin:50924;   KEGG:C18933
 xref_mesh: MESH:D002703
 xref: PMID:11864786;   PMID:19408893;   PMID:20797618;   PPDB:1297


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tetrachloro-1,4-benzoquinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO Chloranil results in increased activity of CASP3 protein CTD PMID:30905860 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions
decreases activity
ISO Curcumin inhibits the reaction [Chloranil results in decreased activity of CAT protein] CTD PMID:25123790 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Esm1 endothelial cell-specific molecule 1 increases expression ISO Chloranil results in increased expression of ESM1 mRNA CTD PMID:24214992 NCBI chr 2:44,876,067...44,884,805
Ensembl chr 2:44,876,067...44,884,804
JBrowse link
G Fbxo32 F-box protein 32 increases expression ISO Chloranil results in increased expression of FBXO32 mRNA CTD PMID:24214992 NCBI chr 7:89,731,626...89,764,761
Ensembl chr 7:89,730,232...89,765,436
JBrowse link
G Ftl1 ferritin light chain 1 multiple interactions
increases expression
ISO [Chloranil results in increased abundance of 5-hydroxymethylcytosine] which results in increased expression of FTL mRNA
Chloranil results in increased expression of FTL mRNA; Chloranil results in increased expression of FTL protein
CTD PMID:24214992 NCBI chr 1:95,936,390...95,938,234
Ensembl chr 1:95,936,387...95,939,725
JBrowse link
G Gosr2 golgi SNAP receptor complex member 2 increases expression ISO Chloranil results in increased expression of GOSR2 mRNA CTD PMID:24214992 NCBI chr10:88,585,291...88,605,642
Ensembl chr10:88,586,299...88,605,625
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity
multiple interactions
ISO Chloranil results in increased activity of GPT protein
Curcumin inhibits the reaction [Chloranil results in increased activity of GPT protein]
CTD PMID:25123790 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO [Curcumin co-treated with Chloranil] results in increased expression of HMOX1 protein
Chloranil results in increased expression of HMOX1 protein
CTD PMID:25123790 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
ISO Chloranil results in increased expression of IL1B protein
Curcumin inhibits the reaction [Chloranil results in increased expression of IL1B protein]
CTD PMID:25123790 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO Chloranil results in increased expression of IL6 protein
Curcumin inhibits the reaction [Chloranil results in increased expression of IL6 protein]
CTD PMID:25123790 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
ISO Chloranil results in increased expression of NOS2 protein
Curcumin inhibits the reaction [Chloranil results in increased expression of NOS2 protein]
CTD PMID:25123790 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
ISO Chloranil results in increased expression of NQO1 protein
[Curcumin co-treated with Chloranil] results in increased expression of NQO1 protein
CTD PMID:25123790 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO Chloranil results in increased expression of PTGS2 protein
Curcumin inhibits the reaction [Chloranil results in increased expression of PTGS2 protein]
CTD PMID:25123790 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression
affects localization
ISO Curcumin inhibits the reaction [Chloranil affects the localization of RELA protein modified form]; Curcumin inhibits the reaction [Chloranil results in increased expression of RELA protein] CTD PMID:25123790 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rnd3 Rho family GTPase 3 increases expression ISO Chloranil results in increased expression of RND3 mRNA CTD PMID:24214992 NCBI chr 3:35,571,929...35,589,283
Ensembl chr 3:35,571,143...35,589,327
JBrowse link
G Tet1 tet methylcytosine dioxygenase 1 multiple interactions ISO TET1 protein affects the reaction [Chloranil results in increased chemical synthesis of 5-hydroxymethylcytosine]; TET1 protein affects the reaction [Chloranil results in increased oxidation of 5-Methylcytosine] CTD PMID:24214992 NCBI chr20:25,761,042...25,840,926
Ensembl chr20:25,768,120...25,833,052
JBrowse link
G Tet2 tet methylcytosine dioxygenase 2 multiple interactions ISO TET2 protein affects the reaction [Chloranil results in increased chemical synthesis of 5-hydroxymethylcytosine]; TET2 protein affects the reaction [Chloranil results in increased oxidation of 5-Methylcytosine] CTD PMID:24214992 NCBI chr 2:221,988,645...222,072,813
Ensembl chr 2:221,988,645...222,072,534
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Chloranil results in increased expression of TNF protein CTD PMID:25123790 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Ubc ubiquitin C increases expression
multiple interactions
ISO Chloranil results in increased expression of UBC mRNA
[Chloranil results in increased abundance of 5-hydroxymethylcytosine] which results in increased expression of UBC mRNA
CTD PMID:24214992 NCBI chr12:31,238,889...31,243,924
Ensembl chr12:31,239,152...31,243,925
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        biochemical role 19389
          metabolite 19364
            tetrachloro-1,4-benzoquinone 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      ketone 16923
                                        cyclic ketone 15391
                                          quinone 8379
                                            benzoquinones 736
                                              1,4-benzoquinones 731
                                                tetrachloro-1,4-benzoquinone 19
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