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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tetrachloro-1,4-benzoquinone
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Accession:CHEBI:36703 term browser browse the term
Definition:A member of the class of 1,4-benzoquiones that is 1,4-benzoquinone in which all four hydrogens are substituted by chlorines.
Synonyms:exact_synonym: 2,3,5,6-tetrachlorocyclohexa-2,5-diene-1,4-dione
 related_synonym: 2,3,5,6-Tetrachlor-1,4-benzochinon;   2,3,5,6-tetrachloro-1,4-benzoquinone;   2,3,5,6-tetrachloro-2,5-cyclohexadiene-1,4-dione;   2,3,5,6-tetrachloro-p-benzoquinone;   2,3,5,6-tetrachlorobenzo-1,4-quinone;   Formula=C6Cl4O2;   InChI=1S/C6Cl4O2/c7-1-2(8)6(12)4(10)3(9)5(1)11;   InChIKey=UGNWTBMOAKPKBL-UHFFFAOYSA-N;   SMILES=ClC1=C(Cl)C(=O)C(Cl)=C(Cl)C1=O;   alpha-chloranil;   chloranil;   p-Chloranil;   tetrachloro-p-benzoquinone;   tetrachlorobenzoquinone;   tetrachloroparabenzoquinone
 xref: Beilstein:393006;   CAS:118-75-2;   Gmelin:50924;   KEGG:C18933
 xref_mesh: MESH:D002703
 xref: PMID:11864786;   PMID:19408893;   PMID:20797618;   PPDB:1297


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tetrachloro-1,4-benzoquinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO Chloranil results in increased activity of CASP3 protein CTD PMID:30905860 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions
decreases activity
ISO Curcumin inhibits the reaction [Chloranil results in decreased activity of CAT protein] CTD PMID:25123790 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Esm1 endothelial cell-specific molecule 1 increases expression ISO Chloranil results in increased expression of ESM1 mRNA CTD PMID:24214992 NCBI chr 2:45,104,392...45,113,130
Ensembl chr 2:45,104,305...45,113,131
JBrowse link
G Fbxo32 F-box protein 32 increases expression ISO Chloranil results in increased expression of FBXO32 mRNA CTD PMID:24214992 NCBI chr 7:98,065,664...98,098,071
Ensembl chr 7:98,063,735...98,098,268
JBrowse link
G Ftl1 ferritin light chain 1 multiple interactions
increases expression
ISO [Chloranil results in increased abundance of 5-hydroxymethylcytosine] which results in increased expression of FTL mRNA
Chloranil results in increased expression of FTL mRNA; Chloranil results in increased expression of FTL protein
CTD PMID:24214992 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
JBrowse link
G Gosr2 golgi SNAP receptor complex member 2 increases expression ISO Chloranil results in increased expression of GOSR2 mRNA CTD PMID:24214992 NCBI chr10:91,735,772...91,756,123
Ensembl chr10:91,736,780...91,756,081
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity
multiple interactions
ISO Chloranil results in increased activity of GPT protein
Curcumin inhibits the reaction [Chloranil results in increased activity of GPT protein]
CTD PMID:25123790 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO [Curcumin co-treated with Chloranil] results in increased expression of HMOX1 protein
Chloranil results in increased expression of HMOX1 protein
CTD PMID:25123790 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
ISO Chloranil results in increased expression of IL1B protein
Curcumin inhibits the reaction [Chloranil results in increased expression of IL1B protein]
CTD PMID:25123790 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO Chloranil results in increased expression of IL6 protein
Curcumin inhibits the reaction [Chloranil results in increased expression of IL6 protein]
CTD PMID:25123790 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
ISO Chloranil results in increased expression of NOS2 protein
Curcumin inhibits the reaction [Chloranil results in increased expression of NOS2 protein]
CTD PMID:25123790 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
ISO Chloranil results in increased expression of NQO1 protein
[Curcumin co-treated with Chloranil] results in increased expression of NQO1 protein
CTD PMID:25123790 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO Chloranil results in increased expression of PTGS2 protein
Curcumin inhibits the reaction [Chloranil results in increased expression of PTGS2 protein]
CTD PMID:25123790 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression
affects localization
ISO Curcumin inhibits the reaction [Chloranil affects the localization of RELA protein modified form]; Curcumin inhibits the reaction [Chloranil results in increased expression of RELA protein] CTD PMID:25123790 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rnd3 Rho family GTPase 3 increases expression ISO Chloranil results in increased expression of RND3 mRNA CTD PMID:24214992 NCBI chr 3:36,643,374...36,660,727
Ensembl chr 3:36,642,587...36,660,758
JBrowse link
G Tet1 tet methylcytosine dioxygenase 1 multiple interactions ISO TET1 protein affects the reaction [Chloranil results in increased chemical synthesis of 5-hydroxymethylcytosine]; TET1 protein affects the reaction [Chloranil results in increased oxidation of 5-Methylcytosine] CTD PMID:24214992 NCBI chr20:27,359,122...27,438,039
Ensembl chr20:27,366,213...27,437,427
JBrowse link
G Tet2 tet methylcytosine dioxygenase 2 multiple interactions ISO TET2 protein affects the reaction [Chloranil results in increased chemical synthesis of 5-hydroxymethylcytosine]; TET2 protein affects the reaction [Chloranil results in increased oxidation of 5-Methylcytosine] CTD PMID:24214992 NCBI chr 2:238,719,389...238,802,975
Ensembl chr 2:238,720,835...238,803,024
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Chloranil results in increased expression of TNF protein CTD PMID:25123790 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Ubc ubiquitin C increases expression
multiple interactions
ISO Chloranil results in increased expression of UBC mRNA
[Chloranil results in increased abundance of 5-hydroxymethylcytosine] which results in increased expression of UBC mRNA
CTD PMID:24214992 NCBI chr12:36,638,457...36,642,734
Ensembl chr12:36,638,457...36,642,734
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            tetrachloro-1,4-benzoquinone 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      ketone 16140
                                        cyclic ketone 13810
                                          quinone 8336
                                            benzoquinones 715
                                              1,4-benzoquinones 712
                                                tetrachloro-1,4-benzoquinone 19
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.