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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:phosphocholines
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Accession:CHEBI:36700 term browser browse the term
Definition:Any compound having phosphocholine as part of its structure.
Synonyms:related_synonym: O-phosphocholines;   choline phosphates;   phosphorylcholines


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1,2-dihexadecanoyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions ISO 1,2-Dipalmitoylphosphatidylcholine inhibits the reaction [Asbestos, Crocidolite results in increased secretion of CXCL8 protein] CTD PMID:19041333 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO 1,2-Dipalmitoylphosphatidylcholine inhibits the reaction [Asbestos, Crocidolite results in increased secretion of IL6 protein] CTD PMID:19041333 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Prnp prion protein multiple interactions
affects folding		 ISO Copper affects the reaction [1,2-Dipalmitoylphosphatidylcholine affects the folding of PRNP protein modified form] CTD PMID:20936829 NCBI chr 2:131,751,848...131,780,356
Ensembl chr 2:131,751,848...131,780,349 		JBrowse link
1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fech ferrochelatase affects abundance EXP FECH protein affects the abundance of 1-palmitoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholine CTD PMID:29906468 NCBI chr18:64,589,613...64,622,169
Ensembl chr18:64,585,985...64,623,322 		JBrowse link
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fech ferrochelatase affects abundance EXP FECH protein affects the abundance of 1-palmitoyl-2-linoleoylphosphatidylcholine CTD PMID:29906468 NCBI chr18:64,589,613...64,622,169
Ensembl chr18:64,585,985...64,623,322 		JBrowse link
1-O-oleoyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 multiple interactions EXP [NR5A2 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of 1-oleoyl lysophosphatidylcholine CTD PMID:29515023 NCBI chr 1:136,770,300...136,888,186
Ensembl chr 1:136,770,309...136,888,186 		JBrowse link
G Smad3 SMAD family member 3 decreases abundance EXP SMAD3 protein results in decreased abundance of 1-oleoyl lysophosphatidylcholine CTD PMID:23034213 NCBI chr 9:63,554,048...63,665,276
Ensembl chr 9:63,554,049...63,665,276 		JBrowse link
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of AGTR1 mRNA CTD PMID:16386258 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of ALOX5 mRNA CTD PMID:16386258 NCBI chr 6:116,387,030...116,438,139
Ensembl chr 6:116,387,038...116,438,139 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of CCR2 mRNA CTD PMID:16386258 NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594 		JBrowse link
G Cd68 CD68 antigen increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of CD68 mRNA CTD PMID:16386258 NCBI chr11:69,555,039...69,556,996
Ensembl chr11:69,555,039...69,556,979 		JBrowse link
G Crp C-reactive protein, pentraxin-related increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of CRP mRNA CTD PMID:16386258 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of CXCL8 mRNA CTD PMID:16386258 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions
increases phosphorylation		 ISO AG 1879 inhibits the reaction [1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of GJA1 protein]; resveratrol inhibits the reaction [1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of GJA1 protein] CTD PMID:24079413 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609 		JBrowse link
G Il1a interleukin 1 alpha increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of IL1A mRNA CTD PMID:16386258 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of IL1B mRNA CTD PMID:16386258 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Kcnab2 potassium voltage-gated channel, shaker-related subfamily, beta member 2 multiple interactions ISO [KCNAB2 protein co-treated with NADP] results in increased reduction of 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine CTD PMID:21296056 NCBI chr 4:152,475,201...152,561,991
Ensembl chr 4:152,475,199...152,562,367 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of MAPK1 protein
resveratrol inhibits the reaction [1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of MAPK1 protein]		 CTD PMID:24079413 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO resveratrol inhibits the reaction [1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of MAPK3 protein] CTD PMID:24079413 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of OLR1 mRNA CTD PMID:16386258 NCBI chr 6:129,456,113...129,484,312
Ensembl chr 6:129,462,207...129,484,128 		JBrowse link
G Ptafr platelet-activating factor receptor affects binding
multiple interactions		 ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine binds to PTAFR protein
1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]		 CTD PMID:16386258 NCBI chr 4:132,291,378...132,309,994
Ensembl chr 4:132,291,378...132,309,994 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of PTGS1 mRNA CTD PMID:16386258 NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of PTGS2 mRNA CTD PMID:16386258 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Sele selectin, endothelial cell increases expression
increases secretion		 ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of SELE mRNA
1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased secretion of SELE protein		 CTD PMID:16386258 NCBI chr 1:163,867,200...163,886,056
Ensembl chr 1:163,875,773...163,885,246 		JBrowse link
G Src Rous sarcoma oncogene multiple interactions
increases phosphorylation		 ISO resveratrol inhibits the reaction [1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of SRC protein] CTD PMID:24079413 NCBI chr 2:157,265,828...157,313,758
Ensembl chr 2:157,260,364...157,313,782 		JBrowse link
G Timp4 tissue inhibitor of metalloproteinase 4 increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of TIMP4 mRNA CTD PMID:16386258 NCBI chr 6:115,221,405...115,229,166
Ensembl chr 6:115,218,853...115,229,166 		JBrowse link
G Tnf tumor necrosis factor increases expression
increases secretion		 ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of TNF mRNA
1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased secretion of TNF protein		 CTD PMID:16386258 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lipg lipase, endothelial increases hydrolysis ISO LIPG protein results in increased hydrolysis of 1-O-hexadecyl-2-arachidonyl-sn-glycero-3-phosphocholine CTD PMID:15953354 NCBI chr18:75,072,393...75,095,380
Ensembl chr18:75,072,393...75,094,334 		JBrowse link
1-stearoyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lipc lipase, hepatic multiple interactions EXP [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of stearoyl alpha-lysolecithin CTD PMID:24777581 NCBI chr 9:70,705,410...70,859,503
Ensembl chr 9:70,705,410...70,859,508 		JBrowse link
G Lipg lipase, endothelial multiple interactions EXP [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of stearoyl alpha-lysolecithin CTD PMID:24777581 NCBI chr18:75,072,393...75,095,380
Ensembl chr18:75,072,393...75,094,334 		JBrowse link
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a increases expression ISO Platelet Activating Factor results in increased expression of AGTR1 mRNA CTD PMID:16386258 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850 		JBrowse link
G Alox12 arachidonate 12-lipoxygenase increases expression ISO Platelet Activating Factor results in increased expression of ALOX12 mRNA CTD PMID:16386258 NCBI chr11:70,132,283...70,146,206
Ensembl chr11:70,132,283...70,146,179 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions
increases expression		 ISO [sodium arsenite co-treated with Platelet Activating Factor co-treated with Arachidonic Acid] results in increased phosphorylation of and results in increased activity of ALOX5 protein; [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Calcimycin results in increased abundance of Platelet Activating Factor]
Platelet Activating Factor results in increased expression of ALOX5 mRNA		 CTD PMID:8387780 PMID:10779545 PMID:16386258 NCBI chr 6:116,387,030...116,438,139
Ensembl chr 6:116,387,038...116,438,139 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases secretion		 ISO Foropafant inhibits the reaction [Platelet Activating Factor results in increased secretion of CCL2 protein] CTD PMID:15149885 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 increases expression ISO Platelet Activating Factor results in increased expression of CCR2 mRNA CTD PMID:16386258 NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594 		JBrowse link
G Crp C-reactive protein, pentraxin-related increases expression ISO Platelet Activating Factor results in increased expression of CRP mRNA CTD PMID:16386258 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 increases expression ISO Platelet Activating Factor results in increased expression of CX3CR1 mRNA CTD PMID:16386258 NCBI chr 9:119,877,749...119,897,362
Ensembl chr 9:119,877,749...119,898,945 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions
increases secretion		 ISO Foropafant inhibits the reaction [Platelet Activating Factor results in increased secretion of CXCL8 protein] CTD PMID:15149885 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Edn1 endothelin 1 multiple interactions
increases abundance		 ISO Carbon Tetrachloride promotes the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor]; EDNRB protein affects the reaction [Carbon Tetrachloride promotes the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor]]; EDNRB protein affects the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor] CTD PMID:18205269 NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466 		JBrowse link
G Ednrb endothelin receptor type B multiple interactions ISO EDNRB protein affects the reaction [Carbon Tetrachloride promotes the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor]]; EDNRB protein affects the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor] CTD PMID:18205269 NCBI chr14:104,052,055...104,081,764
Ensembl chr14:104,052,061...104,081,838 		JBrowse link
G Egr1 early growth response 1 increases expression ISO Platelet Activating Factor results in increased expression of EGR1 mRNA CTD PMID:16386258 NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037 		JBrowse link
G Gusb glucuronidase, beta multiple interactions ISO [Platelet Activating Factor co-treated with Cytochalasin B] results in increased secretion of GUSB protein; IMMLG5521 inhibits the reaction [[Platelet Activating Factor co-treated with Cytochalasin B] results in increased secretion of GUSB protein] CTD PMID:23850278 NCBI chr 5:130,011,278...130,031,890
Ensembl chr 5:130,017,852...130,031,890 		JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Platelet Activating Factor results in increased expression of IL1A mRNA CTD PMID:16386258 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
increases secretion		 ISO Platelet Activating Factor results in increased expression of IL1B mRNA
[Platelet Activating Factor co-treated with MIR149 mRNA] affects the secretion of IL1B protein; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased secretion of IL1B protein]		 CTD PMID:16386258 PMID:32830409 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases secretion		 ISO [Platelet Activating Factor co-treated with MIR149 mRNA] affects the secretion of IL6 protein; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased secretion of IL6 protein] CTD PMID:32830409 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Itgam integrin alpha M multiple interactions
increases expression		 ISO Foropafant inhibits the reaction [Platelet Activating Factor results in increased expression of ITGAM protein]; Isoproterenol promotes the reaction [Theophylline inhibits the reaction [Platelet Activating Factor results in increased expression of ITGAM protein]]; Theophylline inhibits the reaction [Platelet Activating Factor results in increased expression of ITGAM protein] CTD PMID:9762784 PMID:11116075 NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663 		JBrowse link
G Ltb4r1 leukotriene B4 receptor 1 affects response to substance EXP LTB4R1 protein affects the susceptibility to Platelet Activating Factor CTD PMID:10934231 NCBI chr14:56,002,154...56,005,951
Ensembl chr14:56,003,419...56,005,951 		JBrowse link
G Mir149 microRNA 149 decreases expression
multiple interactions		 ISO Platelet Activating Factor results in decreased expression of MIR149 mRNA
[Platelet Activating Factor co-treated with MIR149 mRNA] affects the secretion of IL1B protein; [Platelet Activating Factor co-treated with MIR149 mRNA] affects the secretion of IL6 protein; [Platelet Activating Factor co-treated with MIR149 mRNA] affects the secretion of TNF protein; [Platelet Activating Factor co-treated with PVT1 mRNA] affects the expression of MIR149 mRNA		 CTD PMID:32830409 NCBI chr 1:92,778,100...92,778,165
Ensembl chr 1:92,778,100...92,778,165 		JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression ISO Platelet Activating Factor results in increased expression of MMP13 mRNA CTD PMID:16386258 NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331 		JBrowse link
G Myd88 myeloid differentiation primary response gene 88 multiple interactions
increases expression		 ISO PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased expression of MYD88 protein] CTD PMID:32830409 NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477 		JBrowse link
G Nceh1 neutral cholesterol ester hydrolase 1 multiple interactions EXP NCEH1 protein inhibits the reaction [[Chlorpyrifos metabolite co-treated with Cytidine Diphosphate Choline] results in increased abundance of Platelet Activating Factor] CTD PMID:18164358 NCBI chr 3:27,237,153...27,299,112
Ensembl chr 3:27,237,114...27,338,757 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions
increases degradation		 EXP Acetylcysteine inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; BN 50739 inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; Genistein inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; herbimycin inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; Vitamin E inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein] CTD PMID:10921504 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 increases expression ISO Platelet Activating Factor results in increased expression of OLR1 mRNA CTD PMID:16386258 NCBI chr 6:129,456,113...129,484,312
Ensembl chr 6:129,462,207...129,484,128 		JBrowse link
G Pla2g7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) multiple interactions
increases expression		 ISO [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Platelet Activating Factor] results in increased expression of PLA2G7 mRNA; bepafant inhibits the reaction [Platelet Activating Factor results in increased expression of PLA2G7 mRNA] CTD PMID:21432021 NCBI chr17:43,879,009...43,923,093
Ensembl chr17:43,878,989...43,923,092 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression ISO Platelet Activating Factor results in decreased expression of PPARA mRNA CTD PMID:16386258 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Ptafr platelet-activating factor receptor multiple interactions
increases expression
increases phosphorylation
affects binding		 ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]; BN 50730 inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]; BN 50739 inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]; CMI 392 inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]; MK 287 inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]; zileuton inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]
Platelet Activating Factor results in increased expression of PTAFR mRNA
Platelet Activating Factor results in increased phosphorylation of PTAFR protein
bepafant inhibits the reaction [Platelet Activating Factor results in increased expression of PTAFR mRNA]; Carbon Tetrachloride promotes the reaction [Platelet Activating Factor binds to PTAFR protein]; RGS4 protein inhibits the reaction [Platelet Activating Factor results in increased phosphorylation of PTAFR protein]; TNF protein affects the reaction [Platelet Activating Factor results in increased expression of PTAFR mRNA]		 CTD PMID:9065783 PMID:10447766 PMID:11297424 PMID:11529688 PMID:16386258 More... NCBI chr 4:132,291,378...132,309,994
Ensembl chr 4:132,291,378...132,309,994 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases expression ISO Platelet Activating Factor results in increased expression of PTGS1 mRNA CTD PMID:16386258 NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Platelet Activating Factor results in increased expression of PTGS2 mRNA CTD PMID:16386258 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Pvt1 Pvt1 oncogene increases expression
multiple interactions		 ISO Platelet Activating Factor results in increased expression of PVT1 mRNA
[Platelet Activating Factor co-treated with PVT1 mRNA] affects the expression of MIR149 mRNA; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased expression of MYD88 protein]; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased secretion of IL1B protein]; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased secretion of IL6 protein]; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased secretion of TNF protein]		 CTD PMID:32830409 NCBI chr15:61,909,835...62,132,064
Ensembl chr15:61,909,817...62,249,945 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 multiple interactions ISO RGS4 protein inhibits the reaction [Platelet Activating Factor results in increased phosphorylation of PTAFR protein] CTD PMID:11297424 NCBI chr 1:169,569,046...169,575,211
Ensembl chr 1:169,569,046...169,575,211 		JBrowse link
G Sele selectin, endothelial cell increases expression ISO Platelet Activating Factor results in increased expression of SELE mRNA CTD PMID:16386258 NCBI chr 1:163,867,200...163,886,056
Ensembl chr 1:163,875,773...163,885,246 		JBrowse link
G Sell selectin, lymphocyte multiple interactions
increases secretion		 ISO Isoproterenol promotes the reaction [Theophylline inhibits the reaction [Platelet Activating Factor results in increased secretion of SELL protein]]; Theophylline inhibits the reaction [Platelet Activating Factor results in increased secretion of SELL protein] CTD PMID:9762784 NCBI chr 1:163,889,556...163,908,354
Ensembl chr 1:163,889,551...163,911,750 		JBrowse link
G Selp selectin, platelet multiple interactions
increases expression		 ISO Foropafant inhibits the reaction [Platelet Activating Factor results in increased expression of SELP protein] CTD PMID:11116075 NCBI chr 1:163,942,833...163,977,595
Ensembl chr 1:163,942,833...163,977,595 		JBrowse link
G Timp4 tissue inhibitor of metalloproteinase 4 increases expression ISO Platelet Activating Factor results in increased expression of TIMP4 mRNA CTD PMID:16386258 NCBI chr 6:115,221,405...115,229,166
Ensembl chr 6:115,218,853...115,229,166 		JBrowse link
G Tnf tumor necrosis factor increases secretion
multiple interactions
increases expression		 ISO
EXP		 Platelet Activating Factor results in increased secretion of TNF protein
[Platelet Activating Factor co-treated with MIR149 mRNA] affects the secretion of TNF protein; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased secretion of TNF protein]
TNF protein affects the reaction [Platelet Activating Factor results in increased expression of PTAFR mRNA]
Platelet Activating Factor results in increased expression of TNF mRNA
Acetylcysteine inhibits the reaction [Platelet Activating Factor results in increased expression of TNF mRNA]; BN 50739 inhibits the reaction [Platelet Activating Factor results in increased expression of TNF mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Platelet Activating Factor results in increased expression of TNF mRNA]; Vitamin E inhibits the reaction [Platelet Activating Factor results in increased expression of TNF mRNA]		 CTD PMID:9065783 PMID:10921504 PMID:16386258 PMID:32830409 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnf tumor necrosis factor increases expression ISO platelet-activating factor increases expression of Tnf protein in portal stenosis rat plasma RGD PMID:10452877 RGD:38508900 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
CDP-choline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 decreases expression ISO Cytidine Diphosphate Choline results in decreased expression of CASP3 protein CTD PMID:12443983 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO Cytidine Diphosphate Choline results in decreased expression of ICAM1 mRNA CTD PMID:16193989 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Nceh1 neutral cholesterol ester hydrolase 1 multiple interactions EXP NCEH1 protein inhibits the reaction [[Chlorpyrifos metabolite co-treated with Cytidine Diphosphate Choline] results in increased abundance of Platelet Activating Factor] CTD PMID:18164358 NCBI chr 3:27,237,153...27,299,112
Ensembl chr 3:27,237,114...27,338,757 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 decreases expression ISO Cytidine Diphosphate Choline results in decreased expression of PARP1 protein modified form CTD PMID:12443983 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Sirt1 sirtuin 1 increases expression
multiple interactions		 ISO Cytidine Diphosphate Choline results in increased expression of SIRT1 protein
Cytidine Diphosphate Choline results in increased expression of and results in increased activity of SIRT1 protein		 CTD PMID:23600725 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
ecothiopate iodide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP Echothiophate Iodide results in decreased activity of ACHE protein CTD PMID:16978018 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728 		JBrowse link
G Alb albumin affects binding ISO Echothiophate Iodide binds to ALB protein CTD PMID:15525694 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Bche butyrylcholinesterase decreases activity
multiple interactions		 ISO Echothiophate Iodide results in decreased activity of BCHE protein
Echothiophate Iodide inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]		 CTD PMID:7377577 PMID:16213467 PMID:17698511 PMID:21802514 NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748 		JBrowse link
G Nceh1 neutral cholesterol ester hydrolase 1 decreases activity EXP Echothiophate Iodide results in decreased activity of NCEH1 protein CTD PMID:16978018 NCBI chr 3:27,237,153...27,299,112
Ensembl chr 3:27,237,114...27,338,757 		JBrowse link
edelfosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO edelfosine inhibits the reaction [Nicotine results in increased phosphorylation of BCL2 protein]; edelfosine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2 protein]; edelfosine promotes the reaction [Cytarabine results in decreased expression of BCL2 protein] CTD PMID:9295281 PMID:12421819 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 multiple interactions ISO edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]]; edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [cinnamaldehyde results in increased activity of TRPA1 protein]] CTD PMID:17571167 NCBI chr13:95,648,226...95,661,748
Ensembl chr13:95,648,240...95,661,735 		JBrowse link
G Lep leptin multiple interactions EXP edelfosine inhibits the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Plcb2 phospholipase C, beta 2 multiple interactions ISO edelfosine inhibits the reaction [Cytarabine affects the localization of PLCB2 protein]; edelfosine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PLCB2 protein] CTD PMID:9295281 NCBI chr 2:118,535,484...118,559,140
Ensembl chr 2:118,537,998...118,558,919 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO edelfosine results in increased expression of PTGS2 protein CTD PMID:12485854 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 multiple interactions ISO edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]]; edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [cinnamaldehyde results in increased activity of TRPA1 protein]] CTD PMID:17571167 NCBI chr 1:14,942,868...14,989,086
Ensembl chr 1:14,942,872...14,989,086 		JBrowse link
glycerylphosphorylcholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gdpd5 glycerophosphodiester phosphodiesterase domain containing 5 affects abundance ISO GDPD5 protein affects the abundance of Glycerylphosphorylcholine CTD PMID:33617914 NCBI chr 7:99,027,976...99,111,082
Ensembl chr 7:99,030,621...99,111,084 		JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 affects abundance ISO PNPLA6 protein affects the abundance of Glycerylphosphorylcholine CTD PMID:36336212 NCBI chr 8:3,565,341...3,594,267
Ensembl chr 8:3,565,384...3,594,267 		JBrowse link
lysophosphatidylcholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmal1 basic helix-loop-helix ARNT like 1 affects abundance EXP BMAL1 gene mutant form affects the abundance of Lysophosphatidylcholines CTD PMID:27056296 NCBI chr 7:112,777,820...112,913,333
Ensembl chr 7:112,806,672...112,913,333 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions		 ISO Lysophosphatidylcholines results in increased expression of CASP3 protein
GPR4 protein promotes the reaction [Lysophosphatidylcholines results in increased expression of CASP3 protein]		 CTD PMID:34293432 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Cav1 caveolin 1, caveolae protein multiple interactions
increases expression		 ISO alpha-Tocopherol inhibits the reaction [Lysophosphatidylcholines results in increased expression of CAV1 mRNA]; quercetin 3-O-glucuronide inhibits the reaction [Lysophosphatidylcholines results in increased expression of CAV1 mRNA]; Quercetin inhibits the reaction [Lysophosphatidylcholines results in increased expression of CAV1 mRNA]; Quercetin inhibits the reaction [Lysophosphatidylcholines results in increased expression of CAV1 protein]
Lysophosphatidylcholines results in increased expression of CAV1 mRNA; Lysophosphatidylcholines results in increased expression of CAV1 protein		 CTD PMID:27257344 NCBI chr 6:17,306,387...17,341,323
Ensembl chr 6:17,306,334...17,341,451 		JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 multiple interactions EXP [[Capsaicin results in increased chemical synthesis of Lysophosphatidylcholines] which results in increased secretion of Lysophosphatidylcholines] promotes the reaction [ENPP2 results in increased chemical synthesis of lysophosphatidic acid]; [ENPP2 protein co-treated with Lysophosphatidylcholines] results in increased chemical synthesis of lysophosphatidic acid CTD PMID:19014389 NCBI chr15:54,702,297...54,816,284
Ensembl chr15:54,702,297...54,816,288 		JBrowse link
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 increases hydrolysis ISO ENPP7 protein results in increased hydrolysis of Lysophosphatidylcholines CTD PMID:12885774 NCBI chr11:118,879,007...118,884,047
Ensembl chr11:118,879,014...118,884,047 		JBrowse link
G Fscn1 fascin actin-bundling protein 1 increases expression EXP Lysophosphatidylcholines results in increased expression of FSCN1 mRNA CTD PMID:22102721 NCBI chr 5:142,946,110...142,958,944
Ensembl chr 5:142,946,098...142,958,940 		JBrowse link
G Gja1 gap junction protein, alpha 1 increases ubiquitination
multiple interactions		 ISO Lysophosphatidylcholines results in increased ubiquitination of GJA1 protein
Lysophosphatidylcholines affects the localization of and results in increased phosphorylation of GJA1 protein; PRKCE affects the reaction [Lysophosphatidylcholines results in increased phosphorylation of GJA1 protein]		 CTD PMID:23973256 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609 		JBrowse link
G Gpr4 G protein-coupled receptor 4 multiple interactions
increases expression		 ISO GPR4 protein promotes the reaction [Lysophosphatidylcholines results in increased expression of CASP3 protein]; GPR4 protein promotes the reaction [Lysophosphatidylcholines results in increased expression of IL18 protein]; GPR4 protein promotes the reaction [Lysophosphatidylcholines results in increased expression of IL1B protein]; GPR4 protein promotes the reaction [Lysophosphatidylcholines results in increased expression of IL33 protein]; GPR4 protein promotes the reaction [Lysophosphatidylcholines results in increased expression of NLRP3 protein]
Lysophosphatidylcholines results in increased expression of GPR4 mRNA; Lysophosphatidylcholines results in increased expression of GPR4 protein		 CTD PMID:34293432 NCBI chr 7:18,946,463...18,958,101
Ensembl chr 7:18,946,463...18,958,099 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Lysophosphatidylcholines results in increased expression of HMOX1 mRNA CTD PMID:9808084 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression
multiple interactions		 ISO Lysophosphatidylcholines results in increased expression of ICAM1 mRNA
quercetin 3-O-glucuronide inhibits the reaction [Lysophosphatidylcholines results in increased expression of ICAM1 mRNA]; Quercetin inhibits the reaction [Lysophosphatidylcholines results in increased expression of ICAM1 mRNA]		 CTD PMID:27257344 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Il18 interleukin 18 multiple interactions
increases expression		 ISO GPR4 protein promotes the reaction [Lysophosphatidylcholines results in increased expression of IL18 protein] CTD PMID:34293432 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions		 ISO Lysophosphatidylcholines results in increased expression of IL1B protein
GPR4 protein promotes the reaction [Lysophosphatidylcholines results in increased expression of IL1B protein]		 CTD PMID:34293432 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il33 interleukin 33 increases expression
multiple interactions		 ISO Lysophosphatidylcholines results in increased expression of IL33 protein
GPR4 protein promotes the reaction [Lysophosphatidylcholines results in increased expression of IL33 protein]		 CTD PMID:34293432 NCBI chr19:29,902,513...29,938,118
Ensembl chr19:29,902,514...29,938,118 		JBrowse link
G Lama3 laminin, alpha 3 increases expression ISO Lysophosphatidylcholines results in increased expression of LAMA3 mRNA CTD PMID:15541073 NCBI chr18:12,466,806...12,716,070
Ensembl chr18:12,466,876...12,716,070 		JBrowse link
G Lamb3 laminin, beta 3 increases expression ISO Lysophosphatidylcholines results in increased expression of LAMB3 mRNA CTD PMID:15541073 NCBI chr 1:192,976,661...193,026,186
Ensembl chr 1:192,890,007...193,026,186 		JBrowse link
G Lamc2 laminin, gamma 2 increases expression ISO Lysophosphatidylcholines results in increased expression of LAMC2 mRNA CTD PMID:15541073 NCBI chr 1:152,998,502...153,062,193
Ensembl chr 1:152,998,502...153,062,193 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lysophosphatidylcholines results in increased phosphorylation of MAPK1 protein]; resveratrol inhibits the reaction [Lysophosphatidylcholines results in increased phosphorylation of MAPK1 protein] CTD PMID:20564508 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lysophosphatidylcholines results in increased phosphorylation of MAPK3 protein]; resveratrol inhibits the reaction [Lysophosphatidylcholines results in increased phosphorylation of MAPK3 protein] CTD PMID:20564508 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mfsd2a MFSD2 lysolipid transporter A, lysophospholipid increases transport ISO MFSD2A results in increased transport of Lysophosphatidylcholines CTD PMID:26005865 NCBI chr 4:122,840,643...122,855,844
Ensembl chr 4:122,840,643...122,854,981 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions
increases expression		 ISO GPR4 protein promotes the reaction [Lysophosphatidylcholines results in increased expression of NLRP3 protein] CTD PMID:34293432 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions
increases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lysophosphatidylcholines results in increased expression of NOS2 mRNA]; resveratrol inhibits the reaction [Lysophosphatidylcholines results in increased expression of NOS2 mRNA] CTD PMID:20564508 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell multiple interactions
decreases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lysophosphatidylcholines results in decreased expression of NOS3 mRNA]; resveratrol inhibits the reaction [Lysophosphatidylcholines results in decreased expression of NOS3 mRNA] CTD PMID:20564508 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 multiple interactions EXP [NR5A2 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Lysophosphatidylcholines CTD PMID:29515023 NCBI chr 1:136,770,300...136,888,186
Ensembl chr 1:136,770,309...136,888,186 		JBrowse link
G Pah phenylalanine hydroxylase multiple interactions EXP Lysophosphatidylcholines results in increased activity of [PAH protein binds to PAH protein binds to PAH protein binds to PAH protein] CTD PMID:19367645 NCBI chr10:87,357,657...87,419,999
Ensembl chr10:87,357,657...87,419,998 		JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 affects abundance ISO PNPLA6 protein affects the abundance of Lysophosphatidylcholines CTD PMID:36336212 NCBI chr 8:3,565,341...3,594,267
Ensembl chr 8:3,565,384...3,594,267 		JBrowse link
G Prkce protein kinase C, epsilon multiple interactions ISO PRKCE affects the reaction [Lysophosphatidylcholines results in increased phosphorylation of GJA1 protein] CTD PMID:23973256 NCBI chr17:86,472,631...86,965,347
Ensembl chr17:86,475,213...86,965,347 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression
multiple interactions		 ISO Lysophosphatidylcholines results in decreased expression of PTGS1 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lysophosphatidylcholines results in decreased expression of PTGS1 mRNA]; resveratrol inhibits the reaction [Lysophosphatidylcholines results in decreased expression of PTGS1 mRNA]		 CTD PMID:20564508 NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lysophosphatidylcholines results in increased expression of PTGS2 mRNA]; resveratrol inhibits the reaction [Lysophosphatidylcholines results in increased expression of PTGS2 mRNA] CTD PMID:20564508 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Trp53 transformation related protein 53 multiple interactions EXP [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of Lysophosphatidylcholines CTD PMID:30258081 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Trpc5 transient receptor potential cation channel, subfamily C, member 5 multiple interactions ISO Lysophosphatidylcholines promotes the reaction [TRPC5 protein results in increased transport of Calcium]; resveratrol inhibits the reaction [Lysophosphatidylcholines promotes the reaction [TRPC5 protein results in increased transport of Calcium]] CTD PMID:21127073 NCBI chr  X:143,160,323...143,471,176
Ensembl chr  X:143,164,667...143,471,176 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression ISO Lysophosphatidylcholines results in increased expression of VCAM1 mRNA CTD PMID:27257344 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337 		JBrowse link
miltefosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A decreases response to substance
multiple interactions		 ISO ABCB1 protein results in decreased susceptibility to miltefosine
miltefosine binds to and results in decreased activity of ABCB1 protein		 CTD PMID:11355955 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Prkca protein kinase C, alpha decreases phosphorylation ISO miltefosine results in decreased phosphorylation of PRKCA protein CTD PMID:31265827 NCBI chr11:107,824,213...108,237,360
Ensembl chr11:107,824,213...108,234,754 		JBrowse link
phosphatidylcholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B member 11 increases secretion EXP ABCB11 protein results in increased secretion of Phosphatidylcholines CTD PMID:14570929 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958 		JBrowse link
G Abcb1a ATP-binding cassette, sub-family B member 1A affects export
affects transport		 ISO ABCB1 protein affects the export of Phosphatidylcholines
ABCB1 protein affects the transport of Phosphatidylcholines		 CTD PMID:11147995 PMID:11745043 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abcb4 ATP-binding cassette, sub-family B member 4 affects transport
affects export		 EXP
ISO		 ABCB4 protein affects the transport of Phosphatidylcholines
ABCB4 protein affects the export of Phosphatidylcholines		 CTD PMID:11745043 PMID:15696852 NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231 		JBrowse link
G Acat1 acetyl-Coenzyme A acetyltransferase 1 decreases activity ISO Phosphatidylcholines results in decreased activity of ACAT1 protein CTD PMID:12559476 NCBI chr 9:53,491,822...53,521,650
Ensembl chr 9:53,491,822...53,521,682 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression EXP Phosphatidylcholines results in decreased expression of ADIPOQ mRNA CTD PMID:23911798 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions
increases abundance		 EXP
ISO		 PEMT protein promotes the reaction [AHR protein results in increased abundance of Phosphatidylcholines] CTD PMID:29416063 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037 		JBrowse link
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in increased expression of AIFM1 protein CTD PMID:21695227 NCBI chr  X:47,563,821...47,602,440
Ensembl chr  X:47,563,821...47,602,440 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide; [[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines; Edetic Acid inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide]; Penicillamine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide]; Trientine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide] CTD PMID:17964426 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654 		JBrowse link
G As3mt arsenite methyltransferase affects metabolic processing EXP AS3MT gene mutant form affects the metabolism of Phosphatidylcholines CTD PMID:27591999 NCBI chr19:46,695,124...46,729,538
Ensembl chr19:46,695,897...46,729,538 		JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in increased expression of BAX protein CTD PMID:21695227 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in decreased expression of BCL2 protein CTD PMID:21695227 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bmal1 basic helix-loop-helix ARNT like 1 increases abundance EXP BMAL1 gene mutant form results in increased abundance of Phosphatidylcholines CTD PMID:27056296 NCBI chr 7:112,777,820...112,913,333
Ensembl chr 7:112,806,672...112,913,333 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in increased expression of CASP3 protein CTD PMID:21695227 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in increased expression of CASP8 protein CTD PMID:21695227 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in increased expression of CASP9 protein CTD PMID:21695227 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression EXP Phosphatidylcholines results in increased expression of CCL2 mRNA CTD PMID:23911798 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in decreased expression of CCND1 protein CTD PMID:21695227 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO Phosphatidylcholines promotes the reaction [rubitecan results in decreased expression of CCNE1 protein] CTD PMID:21695227 NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in decreased expression of CDK2 protein CTD PMID:21695227 NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in increased expression of CDKN1A protein CTD PMID:21695227 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in increased expression of CDKN1B protein CTD PMID:21695227 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476 		JBrowse link
G Ces1d carboxylesterase 1D decreases expression EXP Phosphatidylcholines results in decreased expression of CES1D mRNA CTD PMID:23911798 NCBI chr 8:93,892,700...93,924,432
Ensembl chr 8:93,892,696...93,924,466 		JBrowse link
G Col1a1 collagen, type I, alpha 1 multiple interactions ISO [silybin co-treated with Phosphatidylcholines co-treated with Vitamin E] inhibits the reaction [Dimethylnitrosamine results in increased expression of COL1A1 mRNA] CTD PMID:16169303 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868 		JBrowse link
G Crp C-reactive protein, pentraxin-related affects binding
decreases activity		 ISO CRP protein binds to Phosphatidylcholines
Phosphatidylcholines results in decreased activity of CRP protein		 CTD PMID:16962105 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects activity ISO Phosphatidylcholines affects the activity of CYP1A2 protein CTD PMID:15966743 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 increases activity ISO Phosphatidylcholines results in increased activity of CYP7A1 protein CTD PMID:12559476 NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633 		JBrowse link
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 increases hydrolysis ISO ENPP7 protein results in increased hydrolysis of Phosphatidylcholines CTD PMID:12885774 NCBI chr11:118,879,007...118,884,047
Ensembl chr11:118,879,014...118,884,047 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO [orlistat results in decreased activity of FASN protein] which results in decreased abundance of Phosphatidylcholines CTD PMID:18723500 NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373 		JBrowse link
G Fgf15 fibroblast growth factor 15 decreases abundance EXP FGF19 protein results in decreased abundance of Phosphatidylcholines CTD PMID:29416063 NCBI chr 7:144,450,269...144,454,690
Ensembl chr 7:144,450,268...144,454,690 		JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO GPX4 mutant form promotes the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite]; GPX4 protein inhibits the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite] CTD PMID:22433871 NCBI chr10:79,883,000...79,892,273
Ensembl chr10:79,883,000...79,892,273 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase increases activity ISO Phosphatidylcholines results in increased activity of HMGCR protein CTD PMID:12559476 NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444 		JBrowse link
G Igf1 insulin-like growth factor 1 increases degradation EXP IGF1 protein results in increased degradation of Phosphatidylcholines CTD PMID:2120207 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904 		JBrowse link
G Il10 interleukin 10 increases expression EXP Phosphatidylcholines results in increased expression of IL10 mRNA CTD PMID:23911798 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions		 EXP Phosphatidylcholines results in increased expression of IL1B mRNA
Phosphatidylcholines results in increased expression of and results in increased secretion of IL1B protein		 CTD PMID:23911798 PMID:30958839 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 increases expression EXP Phosphatidylcholines results in increased expression of IL6 mRNA CTD PMID:23911798 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Lep leptin decreases expression EXP Phosphatidylcholines results in decreased expression of LEP mRNA CTD PMID:23911798 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Lipc lipase, hepatic multiple interactions
increases abundance		 EXP [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of Phosphatidylcholines
LIPC gene mutant form results in increased abundance of Phosphatidylcholines		 CTD PMID:24777581 NCBI chr 9:70,705,410...70,859,503
Ensembl chr 9:70,705,410...70,859,508 		JBrowse link
G Lipe lipase, hormone sensitive increases expression EXP Phosphatidylcholines results in increased expression of LIPE mRNA CTD PMID:23911798 NCBI chr 7:25,078,952...25,097,911
Ensembl chr 7:25,078,952...25,098,135 		JBrowse link
G Lipg lipase, endothelial multiple interactions
increases abundance		 EXP [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of Phosphatidylcholines
LIPG gene mutant form results in increased abundance of Phosphatidylcholines		 CTD PMID:24777581 NCBI chr18:75,072,393...75,095,380
Ensembl chr18:75,072,393...75,094,334 		JBrowse link
G Ltf lactotransferrin multiple interactions EXP [LTF protein co-treated with Phosphatidylcholines co-treated with Phytosterols] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:16141546 NCBI chr 9:110,848,360...110,871,834
Ensembl chr 9:110,848,339...110,871,835 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO [silybin co-treated with Phosphatidylcholines co-treated with Vitamin E] inhibits the reaction [Dimethylnitrosamine results in increased expression of MMP2 mRNA] CTD PMID:16169303 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO NOX4 mutant form inhibits the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite] CTD PMID:22433871 NCBI chr 7:86,893,638...87,047,918
Ensembl chr 7:86,895,304...87,047,918 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases abundance EXP NR0B2 protein results in decreased abundance of Phosphatidylcholines CTD PMID:29416063 NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847 		JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 multiple interactions EXP [NR5A2 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Phosphatidylcholines CTD PMID:29515023 NCBI chr 1:136,770,300...136,888,186
Ensembl chr 1:136,770,309...136,888,186 		JBrowse link
G Pafah1b1 platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 multiple interactions
increases secretion		 ISO PAFAH1B1 protein promotes the reaction [Terbutaline results in increased secretion of Phosphatidylcholines]; PAFAH1B1 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased secretion of Phosphatidylcholines]
PAFAH1B1 protein results in increased secretion of Phosphatidylcholines		 CTD PMID:12013527 NCBI chr11:74,564,775...74,615,210
Ensembl chr11:74,564,775...74,615,496 		JBrowse link
G Pafah2 platelet-activating factor acetylhydrolase 2 multiple interactions ISO PAFAH2 inhibits the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite] CTD PMID:22433871 NCBI chr 4:134,123,631...134,154,723
Ensembl chr 4:134,123,631...134,154,724 		JBrowse link
G Pcyt1a phosphate cytidylyltransferase 1, choline, alpha isoform multiple interactions ISO PCYT1A protein promotes the reaction [PLPP6 protein results in increased chemical synthesis of Phosphatidylcholines] CTD PMID:18930839 NCBI chr16:32,249,739...32,293,883
Ensembl chr16:32,249,739...32,293,888 		JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase multiple interactions ISO
EXP		 PEMT protein promotes the reaction [AHR protein results in increased abundance of Phosphatidylcholines] CTD PMID:29416063 NCBI chr11:59,861,440...59,937,394
Ensembl chr11:59,861,440...59,937,315 		JBrowse link
G Plin1 perilipin 1 increases expression EXP Phosphatidylcholines results in increased expression of PLIN1 mRNA CTD PMID:23911798 NCBI chr 7:79,370,912...79,382,652
Ensembl chr 7:79,369,966...79,382,651 		JBrowse link
G Plpp6 phospholipid phosphatase 6 multiple interactions
increases chemical synthesis		 ISO PCYT1A protein promotes the reaction [PLPP6 protein results in increased chemical synthesis of Phosphatidylcholines] CTD PMID:18930839 NCBI chr19:28,941,320...28,944,201
Ensembl chr19:28,941,353...28,944,211 		JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 decreases expression EXP Phosphatidylcholines results in decreased expression of PNPLA2 mRNA CTD PMID:23911798 NCBI chr 7:141,035,101...141,040,656
Ensembl chr 7:141,035,111...141,040,656 		JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 affects abundance ISO PNPLA6 protein affects the abundance of Phosphatidylcholines CTD PMID:36336212 NCBI chr 8:3,565,341...3,594,267
Ensembl chr 8:3,565,384...3,594,267 		JBrowse link
G Pon2 paraoxonase 2 increases activity
increases expression		 EXP Phosphatidylcholines results in increased activity of PON2 protein
Phosphatidylcholines results in increased expression of PON2 mRNA		 CTD PMID:12615656 NCBI chr 6:5,264,620...5,298,408
Ensembl chr 6:5,264,147...5,298,455 		JBrowse link
G Pon3 paraoxonase 3 multiple interactions EXP Phosphatidylcholines inhibits the reaction [PON3 protein results in increased metabolism of Lovastatin] CTD PMID:12615656 NCBI chr 6:5,216,253...5,256,236
Ensembl chr 6:5,220,852...5,256,286 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma increases expression EXP Phosphatidylcholines results in increased expression of PPARG mRNA CTD PMID:23911798 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Ppargc1b peroxisome proliferative activated receptor, gamma, coactivator 1 beta increases abundance EXP PPARGC1B results in increased abundance of Phosphatidylcholines CTD PMID:17932310 NCBI chr18:61,424,516...61,533,846
Ensembl chr18:61,431,207...61,533,502 		JBrowse link
G Pten phosphatase and tensin homolog affects binding
multiple interactions		 ISO PTEN protein binds to Phosphatidylcholines
[TXN protein binds to PTEN protein] inhibits the reaction [PTEN protein binds to Phosphatidylcholines]		 CTD PMID:15313215 NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560 		JBrowse link
G Retn resistin decreases expression EXP Phosphatidylcholines results in decreased expression of RETN mRNA CTD PMID:23911798 NCBI chr 8:3,705,770...3,709,818
Ensembl chr 8:3,705,770...3,710,110 		JBrowse link
G Sftpa1 surfactant associated protein A1 multiple interactions ISO [SFTPA1 protein polymorphism binds to SFTPA2 protein polymorphism] inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]; Ozone inhibits the reaction [[SFTPA1 protein polymorphism binds to SFTPA2 protein polymorphism] inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]]; Ozone inhibits the reaction [SFTPA1 protein polymorphism inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]] CTD PMID:15065867 NCBI chr14:40,853,745...40,858,330
Ensembl chr14:40,853,739...40,858,409 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [silybin co-treated with Phosphatidylcholines co-treated with Vitamin E] inhibits the reaction [Dimethylnitrosamine results in increased expression of TGFB1 mRNA] CTD PMID:16169303 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 multiple interactions ISO [silybin co-treated with Phosphatidylcholines co-treated with Vitamin E] inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP1 mRNA] CTD PMID:16169303 NCBI chr  X:20,736,524...20,740,972
Ensembl chr  X:20,736,405...20,740,974 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
increases abundance		 ISO
EXP		 GPX4 mutant form promotes the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite]; GPX4 protein inhibits the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite]; NOX4 mutant form inhibits the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite]; PAFAH2 inhibits the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite]
Phosphatidylcholines results in increased expression of TNF mRNA
[LTF protein co-treated with Phosphatidylcholines co-treated with Phytosterols] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Phosphatidylcholines results in increased expression of and results in increased secretion of TNF protein		 CTD PMID:16141546 PMID:22433871 PMID:23911798 PMID:30958839 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO Phosphatidylcholines inhibits the reaction [rubitecan results in increased expression of TP53 protein] CTD PMID:21695227 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO [TXN protein binds to PTEN protein] inhibits the reaction [PTEN protein binds to Phosphatidylcholines] CTD PMID:15313215 NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411 		JBrowse link
phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dek DEK proto-oncogene decreases chemical synthesis ISO DEK protein results in decreased chemical synthesis of Phosphorylcholine CTD PMID:28558019 NCBI chr13:47,238,243...47,261,134
Ensembl chr13:47,238,251...47,259,677 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO [Cerulenin results in decreased activity of FASN protein] which results in decreased abundance of Phosphorylcholine; [orlistat results in decreased activity of FASN protein] which results in decreased abundance of Phosphorylcholine CTD PMID:18723500 NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373 		JBrowse link
G Hsf1 heat shock factor 1 increases activity ISO Phosphorylcholine results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr15:76,361,562...76,385,355
Ensembl chr15:76,361,622...76,386,113 		JBrowse link
G Mmp1b matrix metallopeptidase 1b (interstitial collagenase) multiple interactions
increases expression		 ISO Genistein inhibits the reaction [Phosphorylcholine analog results in increased expression of MMP1 mRNA]; herbimycin inhibits the reaction [Phosphorylcholine analog results in increased expression of MMP1 mRNA] CTD PMID:15878362 NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047 		JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 increases expression
multiple interactions		 ISO Phosphorylcholine analog results in increased expression of TIMP1 mRNA
Genistein inhibits the reaction [Phosphorylcholine analog results in increased expression of TIMP1 mRNA]; herbimycin inhibits the reaction [Phosphorylcholine analog results in increased expression of TIMP1 mRNA]		 CTD PMID:15878362 NCBI chr  X:20,736,524...20,740,972
Ensembl chr  X:20,736,405...20,740,974 		JBrowse link
G Tnf tumor necrosis factor increases expression ISO Phosphorylcholine analog results in increased expression of TNF mRNA CTD PMID:15878362 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
phosphorylcholine chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dek DEK proto-oncogene decreases chemical synthesis ISO DEK protein results in decreased chemical synthesis of Phosphorylcholine CTD PMID:28558019 NCBI chr13:47,238,243...47,261,134
Ensembl chr13:47,238,251...47,259,677 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO [Cerulenin results in decreased activity of FASN protein] which results in decreased abundance of Phosphorylcholine; [orlistat results in decreased activity of FASN protein] which results in decreased abundance of Phosphorylcholine CTD PMID:18723500 NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373 		JBrowse link
G Hsf1 heat shock factor 1 increases activity ISO Phosphorylcholine results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr15:76,361,562...76,385,355
Ensembl chr15:76,361,622...76,386,113 		JBrowse link
G Mmp1b matrix metallopeptidase 1b (interstitial collagenase) multiple interactions
increases expression		 ISO Genistein inhibits the reaction [Phosphorylcholine analog results in increased expression of MMP1 mRNA]; herbimycin inhibits the reaction [Phosphorylcholine analog results in increased expression of MMP1 mRNA] CTD PMID:15878362 NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047 		JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 increases expression
multiple interactions		 ISO Phosphorylcholine analog results in increased expression of TIMP1 mRNA
Genistein inhibits the reaction [Phosphorylcholine analog results in increased expression of TIMP1 mRNA]; herbimycin inhibits the reaction [Phosphorylcholine analog results in increased expression of TIMP1 mRNA]		 CTD PMID:15878362 NCBI chr  X:20,736,524...20,740,972
Ensembl chr  X:20,736,405...20,740,974 		JBrowse link
G Tnf tumor necrosis factor increases expression ISO Phosphorylcholine analog results in increased expression of TNF mRNA CTD PMID:15878362 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22194
    role 22179
      biological role 22178
        molecular messenger 19405
          neurotransmitter 12001
            choline 3697
              choline ester 135
                phosphocholines 135
                  1-o-hexadecyl-2-deoxy-2-thio-s-acetyl-sn-glyceryl-3-phosphorylcholine 0
                  15-methylhexadecasphing-4-enine-1-phosphocholine + 0
                  2-hexadecanoylthio-1-ethylphosphorylcholine 0
                  4-diazoniophenylphosphorylcholine 0
                  6-(O-phosphocholine)oxyhexanoate 0
                  6-(O-phosphocholine)oxyhexanoic acid 0
                  6-(O-phosphocholine)oxyhexanoic acid betaine 0
                  C17 sphingosine-1-phosphocholine 0
                  CDP-choline 5
                  CIML B 0
                  CIML D 0
                  N-acetyl-D-galactosamine-6-phosphocholine 0
                  PG(20:0/21:0) 0
                  SM 8:0 0
                  SM(d14:0/20:0) 0
                  SM(d14:0/22:0) 0
                  SM(d14:0/24:0) 0
                  SM(d14:0/26:0) 0
                  SM(d14:0/27:0) 0
                  SM(d14:0/28:0) 0
                  SM(d16:1/23:0) 0
                  SM(d18:2/20:1) 0
                  SM(d32:1) 0
                  SM(d33:1) 0
                  SM(d34:1) 0
                  SM(d34:2) 0
                  SM(d35:1) 0
                  SM(d36:3) 0
                  SM(d38:1) 0
                  SM(d38:2) 0
                  SM(d40:1) 0
                  SM(d40:2) 0
                  SM(d41:1) 0
                  SM(d41:2) 0
                  SM(d42:1) 0
                  SM(d42:2) 0
                  SM(d43:1) 0
                  SM(d43:2) 0
                  SM(d44:1) 0
                  SM(d44:2) 0
                  [(2S,3R)-3-hydroxy-2-(octadecanoylamino)octadec-5-enyl] 2-(trimethylazaniumyl)ethyl phosphate 0
                  beta-glycerylphosphocholine 0
                  bis(p-nitrophenyl)phosphocholine 0
                  choline alfoscerate 0
                  dithioglycerophosphocholine + 0
                  dodecylphosphocholine 0
                  ecothiopate + 4
                  elaidylphosphocholine 0
                  glycerophosphocholine + 126
                  miltefosine 2
                  monothioglycerophosphocholine + 0
                  p-aminophenylphosphocholine 0
                  p-nitrophenylphosphocholine 0
                  phosphocholine + 6
                  sphinganine-1-phosphocholine 0
                  sphingomyelin + 0
                  sphingosine-1-phosphocholine + 0
                  sphingosylphosphocholine acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22194
    subatomic particle 22186
      composite particle 22186
        hadron 22186
          baryon 22186
            nucleon 22186
              atomic nucleus 22186
                atom 22186
                  main group element atom 22120
                    main group molecular entity 22120
                      s-block molecular entity 21717
                        hydrogen molecular entity 21634
                          hydrides 20777
                            inorganic hydride 18692
                              pnictogen hydride 18672
                                nitrogen hydride 18540
                                  ammonium 8217
                                    ammonium ion derivative 8212
                                      quaternary ammonium ion 5407
                                        cholines 4939
                                          choline 3697
                                            choline ester 135
                                              phosphocholines 135
                                                1-o-hexadecyl-2-deoxy-2-thio-s-acetyl-sn-glyceryl-3-phosphorylcholine 0
                                                15-methylhexadecasphing-4-enine-1-phosphocholine + 0
                                                2-hexadecanoylthio-1-ethylphosphorylcholine 0
                                                4-diazoniophenylphosphorylcholine 0
                                                6-(O-phosphocholine)oxyhexanoate 0
                                                6-(O-phosphocholine)oxyhexanoic acid 0
                                                6-(O-phosphocholine)oxyhexanoic acid betaine 0
                                                C17 sphingosine-1-phosphocholine 0
                                                CDP-choline 5
                                                CIML B 0
                                                CIML D 0
                                                N-acetyl-D-galactosamine-6-phosphocholine 0
                                                PG(20:0/21:0) 0
                                                SM 8:0 0
                                                SM(d14:0/20:0) 0
                                                SM(d14:0/22:0) 0
                                                SM(d14:0/24:0) 0
                                                SM(d14:0/26:0) 0
                                                SM(d14:0/27:0) 0
                                                SM(d14:0/28:0) 0
                                                SM(d16:1/23:0) 0
                                                SM(d18:2/20:1) 0
                                                SM(d32:1) 0
                                                SM(d33:1) 0
                                                SM(d34:1) 0
                                                SM(d34:2) 0
                                                SM(d35:1) 0
                                                SM(d36:3) 0
                                                SM(d38:1) 0
                                                SM(d38:2) 0
                                                SM(d40:1) 0
                                                SM(d40:2) 0
                                                SM(d41:1) 0
                                                SM(d41:2) 0
                                                SM(d42:1) 0
                                                SM(d42:2) 0
                                                SM(d43:1) 0
                                                SM(d43:2) 0
                                                SM(d44:1) 0
                                                SM(d44:2) 0
                                                [(2S,3R)-3-hydroxy-2-(octadecanoylamino)octadec-5-enyl] 2-(trimethylazaniumyl)ethyl phosphate 0
                                                beta-glycerylphosphocholine 0
                                                bis(p-nitrophenyl)phosphocholine 0
                                                choline alfoscerate 0
                                                dithioglycerophosphocholine + 0
                                                dodecylphosphocholine 0
                                                ecothiopate + 4
                                                elaidylphosphocholine 0
                                                glycerophosphocholine + 126
                                                miltefosine 2
                                                monothioglycerophosphocholine + 0
                                                p-aminophenylphosphocholine 0
                                                p-nitrophenylphosphocholine 0
                                                phosphocholine + 6
                                                sphinganine-1-phosphocholine 0
                                                sphingomyelin + 0
                                                sphingosine-1-phosphocholine + 0
                                                sphingosylphosphocholine acid 0
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