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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:chlorocarboxylic acid
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Accession:CHEBI:36685 term browser browse the term
Definition:A carboxylic acid containing at least one chloro group.
Synonyms:related_synonym: chlorocarboxylic acids


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chloroacetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of ATF4 protein] CTD PMID:25451595 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions
increases cleavage		 ISO Acetylcysteine inhibits the reaction [chloroacetic acid results in increased cleavage of ATF6 protein] CTD PMID:25451595 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO SB 203580 inhibits the reaction [chloroacetic acid results in increased expression of BAX mRNA] CTD PMID:23103613 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO chloroacetic acid results in decreased expression of BCL2 mRNA
SB 203580 inhibits the reaction [chloroacetic acid results in decreased expression of BCL2 mRNA]		 CTD PMID:23103613 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Capn1 calpain 1 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of CAPN1 protein] CTD PMID:25451595 NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177 		JBrowse link
G Capn2 calpain 2 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of CAPN2 protein] CTD PMID:25451595 NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969 		JBrowse link
G Casp12 caspase 12 multiple interactions ISO Acetylcysteine inhibits the reaction [chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein]; chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein; HSP90B1 protein promotes the reaction [chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein]; HSPA5 protein promotes the reaction [chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein] CTD PMID:25451595 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage		 ISO chloroacetic acid results in increased cleavage of and results in increased activity of CASP3 protein; HSP90B1 protein promotes the reaction [chloroacetic acid results in increased cleavage of CASP3 protein]; HSPA5 protein promotes the reaction [chloroacetic acid results in increased cleavage of CASP3 protein]; SB 203580 inhibits the reaction [chloroacetic acid results in increased activity of CASP3 protein] CTD PMID:23103613 PMID:25451595 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO chloroacetic acid results in increased cleavage of and results in increased activity of CASP7 protein; SB 203580 inhibits the reaction [chloroacetic acid results in increased activity of CASP7 protein] CTD PMID:23103613 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp9 caspase 9 increases cleavage ISO chloroacetic acid results in increased cleavage of CASP9 protein CTD PMID:23103613 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of DDIT3 protein]
chloroacetic acid results in increased expression of DDIT3 mRNA; chloroacetic acid results in increased expression of DDIT3 protein		 CTD PMID:25451595 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation
multiple interactions		 ISO chloroacetic acid results in increased phosphorylation of EIF2A protein
Acetylcysteine inhibits the reaction [chloroacetic acid results in increased phosphorylation of EIF2A protein]		 CTD PMID:25451595 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases phosphorylation		 ISO Acetylcysteine inhibits the reaction [chloroacetic acid results in increased phosphorylation of EIF2AK3 protein] CTD PMID:25451595 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions
increases phosphorylation		 ISO Acetylcysteine inhibits the reaction [chloroacetic acid results in increased phosphorylation of ERN1 protein] CTD PMID:25451595 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO chloroacetic acid results in decreased expression of G6PC mRNA; chloroacetic acid results in decreased expression of G6PC protein CTD PMID:28189721 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase decreases activity EXP chloroacetic acid results in decreased activity of GAPDH protein CTD PMID:15720133 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Gk glycerol kinase decreases expression
multiple interactions		 ISO chloroacetic acid results in decreased expression of GK mRNA
[ethylene dichloride metabolite results in increased abundance of chloroacetic acid] which results in decreased expression of GK mRNA		 CTD PMID:28960355 NCBI chr  X:50,162,089...50,238,707
Ensembl chr  X:50,163,123...50,238,631 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP [vinylidene chloride co-treated with chloroacetic acid] results in increased expression of HMOX1 protein CTD PMID:9860887 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of HSP90B1 protein]; HSP90B1 protein promotes the reaction [chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein]; HSP90B1 protein promotes the reaction [chloroacetic acid results in increased cleavage of CASP3 protein]
chloroacetic acid results in increased expression of HSP90B1 mRNA; chloroacetic acid results in increased expression of HSP90B1 protein		 CTD PMID:25451595 NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of HSPA5 protein]; HSPA5 protein promotes the reaction [chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein]; HSPA5 protein promotes the reaction [chloroacetic acid results in increased cleavage of CASP3 protein]
chloroacetic acid results in increased expression of HSPA5 mRNA; chloroacetic acid results in increased expression of HSPA5 protein		 CTD PMID:25451595 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions EXP [vinylidene chloride co-treated with chloroacetic acid] results in increased expression of HSPD1 protein CTD PMID:9860887 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression ISO chloroacetic acid results in decreased expression of IGF1 mRNA; chloroacetic acid results in decreased expression of IGF1 protein CTD PMID:31520740 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Mbp myelin basic protein affects expression EXP chloroacetic acid affects the expression of MBP mRNA CTD PMID:22954530 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO chloroacetic acid results in decreased expression of MCL1 mRNA CTD PMID:23103613 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mir451a microRNA 451a multiple interactions
increases expression		 ISO [ethylene dichloride metabolite results in increased abundance of chloroacetic acid] which results in increased expression of MIR451A mRNA
chloroacetic acid results in increased expression of MIR451A mRNA		 CTD PMID:28960355 NCBI chr10:62,961,520...62,961,591
Ensembl chr10:62,961,520...62,961,591 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO chloroacetic acid results in increased cleavage of PARP1 protein CTD PMID:23103613 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pygl glycogen phosphorylase L decreases expression ISO chloroacetic acid results in decreased expression of PYGL mRNA; chloroacetic acid results in decreased expression of PYGL protein CTD PMID:28189721 NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310 		JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of XBP1 protein alternative form]
chloroacetic acid results in increased expression of XBP1 mRNA alternative form; chloroacetic acid results in increased expression of XBP1 protein alternative form		 CTD PMID:25451595 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
chloropropylate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Dihydrotestosterone inhibits the reaction [chloropropylate results in increased activity of AR protein] CTD PMID:15064155 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO chloropropylate results in increased activity of ESR1 protein CTD PMID:15064155 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 increases activity ISO chloropropylate results in increased activity of ESR2 protein CTD PMID:15064155 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO chloropropylate binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
furosemide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO
EXP		 Furosemide promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]
[Furosemide results in increased activity of ABCC2 protein] promotes the reaction [Glucose results in increased secretion of S-(2,4-dinitrophenyl)glutathione]		 CTD PMID:12704183 PMID:19782883 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO Furosemide inhibits the reaction [ABCC3 protein affects the transport of estradiol-17 beta-glucuronide] CTD PMID:12704183 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases export
increases transport		 ISO ABCC4 protein results in increased export of Furosemide
ABCC4 protein results in increased transport of Furosemide		 CTD PMID:17135398 PMID:17939016 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 affects expression EXP Furosemide affects the expression of ADAMTS1 mRNA CTD PMID:16526316 NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103 		JBrowse link
G Agt angiotensinogen increases expression ISO Furosemide results in increased expression of AGT protein modified form CTD PMID:18081357 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects phosphorylation EXP Furosemide affects the phosphorylation of AKT1 protein CTD PMID:17497460 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alb albumin multiple interactions
affects binding		 ISO [bucolome inhibits the reaction [Furosemide binds to ALB protein]] which affects the abundance of Furosemide; bucolome inhibits the reaction [Furosemide binds to ALB protein] CTD PMID:15640375 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP Furosemide results in increased expression of ALDH1A1 mRNA CTD PMID:28138970 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Ang angiogenin affects expression EXP Furosemide affects the expression of ANG mRNA CTD PMID:16526316 NCBI chr15:24,317,733...24,323,361 JBrowse link
G Angpt2 angiopoietin 2 affects expression EXP Furosemide affects the expression of ANGPT2 mRNA CTD PMID:16526316 NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 affects expression EXP Furosemide affects the expression of APAF1 mRNA CTD PMID:17497460 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Aqp2 aquaporin 2 increases expression EXP Furosemide results in increased expression of AQP2 mRNA; Furosemide results in increased expression of AQP2 protein CTD PMID:17584643 NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468 		JBrowse link
G Arc activity-regulated cytoskeleton-associated protein affects expression EXP Furosemide affects the expression of ARC mRNA CTD PMID:17497460 NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378 		JBrowse link
G Atm ATM serine/threonine kinase affects expression EXP Furosemide affects the expression of ATM mRNA CTD PMID:17497460 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Atp6v1b1 ATPase H+ transporting V1 subunit B1 multiple interactions
increases expression		 EXP [Furosemide co-treated with Amiloride] results in increased expression of ATP6V1B1 protein
Furosemide results in increased expression of ATP6V1B1 protein		 CTD PMID:17311909 NCBI chr 4:116,223,799...116,242,475
Ensembl chr 4:116,223,799...116,242,475 		JBrowse link
G Avpr2 arginine vasopressin receptor 2 increases expression EXP Furosemide results in increased expression of AVPR2 mRNA CTD PMID:17584643 NCBI chr  X:151,633,501...151,636,000
Ensembl chr  X:151,633,522...151,635,989 		JBrowse link
G Bad BCL2-associated agonist of cell death affects expression EXP Furosemide affects the expression of BAD mRNA CTD PMID:17497460 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 affects expression EXP Furosemide affects the expression of BAK1 mRNA CTD PMID:17497460 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects expression EXP Furosemide affects the expression of BAX mRNA CTD PMID:17497460 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl10 BCL10, immune signaling adaptor affects expression EXP Furosemide affects the expression of BCL10 mRNA CTD PMID:17497460 NCBI chr 2:234,840,880...234,850,520
Ensembl chr 2:234,840,858...234,850,523 		JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression EXP Furosemide affects the expression of BCL2 mRNA CTD PMID:17497460 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l10 Bcl2-like 10 affects expression EXP Furosemide affects the expression of BCL2L10 mRNA CTD PMID:17497460 NCBI chr 8:76,107,326...76,113,373
Ensembl chr 8:76,107,326...76,113,367 		JBrowse link
G Bcl2l11 Bcl2-like 11 affects expression EXP Furosemide affects the expression of BCL2L11 mRNA CTD PMID:17497460 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Bcl2l2 Bcl2-like 2 affects expression EXP Furosemide affects the expression of BCL2L2 mRNA CTD PMID:17497460 NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624 		JBrowse link
G Bid BH3 interacting domain death agonist affects expression EXP Furosemide affects the expression of BID mRNA CTD PMID:17497460 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Bik BCL2-interacting killer affects expression EXP Furosemide affects the expression of BIK mRNA CTD PMID:17497460 NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 affects expression EXP Furosemide affects the expression of BIRC2 mRNA CTD PMID:17497460 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 affects expression EXP Furosemide affects the expression of BIRC5 mRNA CTD PMID:17497460 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Birc6 baculoviral IAP repeat-containing 6 affects expression EXP Furosemide affects the expression of BIRC6 mRNA CTD PMID:17497460 NCBI chr 6:20,722,922...20,916,396
Ensembl chr 6:20,722,922...20,916,434 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK affects expression EXP Furosemide affects the expression of BOK mRNA CTD PMID:17497460 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476 		JBrowse link
G Bsnd barttin CLCNK type accessory subunit beta decreases expression EXP Furosemide results in decreased expression of BSND mRNA CTD PMID:12759757 NCBI chr 5:121,251,774...121,260,571
Ensembl chr 5:121,251,774...121,260,571 		JBrowse link
G Calb1 calbindin 1 increases expression ISO Furosemide results in increased expression of CALB1 mRNA; Furosemide results in increased expression of CALB1 protein CTD PMID:17652376 NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431 		JBrowse link
G Car2 carbonic anhydrase 2 decreases activity
increases expression		 ISO
EXP		 Furosemide results in decreased activity of CA2 protein
Furosemide results in increased expression of CA2 mRNA		 CTD PMID:16858005 PMID:28138970 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Casp1 caspase 1 affects expression EXP Furosemide affects the expression of CASP1 mRNA CTD PMID:17497460 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp12 caspase 12 affects expression EXP Furosemide affects the expression of CASP12 mRNA CTD PMID:17497460 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp14 caspase 14 affects expression EXP Furosemide affects the expression of CASP14 mRNA CTD PMID:17497460 NCBI chr 7:10,929,759...10,932,591
Ensembl chr 7:10,926,725...10,933,405 		JBrowse link
G Casp2 caspase 2 affects expression EXP Furosemide affects the expression of CASP2 mRNA CTD PMID:17497460 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp3 caspase 3 affects expression EXP Furosemide affects the expression of CASP3 mRNA CTD PMID:17497460 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp4 caspase 4 affects expression EXP Furosemide affects the expression of CASP4 mRNA CTD PMID:17497460 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Casp6 caspase 6 affects expression EXP Furosemide affects the expression of CASP6 mRNA CTD PMID:17497460 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Casp8 caspase 8 affects expression EXP Furosemide affects the expression of CASP8 mRNA CTD PMID:17497460 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 affects expression EXP Furosemide affects the expression of CASP9 mRNA CTD PMID:17497460 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cd40 CD40 molecule affects expression EXP Furosemide affects the expression of CD40 mRNA CTD PMID:17497460 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cd70 Cd70 molecule affects expression EXP Furosemide affects the expression of CD70 mRNA CTD PMID:17497460 NCBI chr 9:2,006,563...2,009,715
Ensembl chr 9:2,006,563...2,009,715 		JBrowse link
G Cdh5 cadherin 5 decreases expression EXP Furosemide results in decreased expression of CDH5 mRNA CTD PMID:16526316 NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368 		JBrowse link
G Chek1 checkpoint kinase 1 affects expression EXP Furosemide affects the expression of CHEK1 mRNA CTD PMID:17497460 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Chek2 checkpoint kinase 2 affects expression EXP Furosemide affects the expression of CHEK2 mRNA CTD PMID:17497460 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Chga chromogranin A increases expression EXP Furosemide results in increased expression of CHGA mRNA CTD PMID:16526316 NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398 		JBrowse link
G Cidea cell death-inducing DFFA-like effector a affects expression EXP Furosemide affects the expression of CIDEA mRNA CTD PMID:17497460 NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481 		JBrowse link
G Cideb cell death-inducing DFFA-like effector b affects expression EXP Furosemide affects the expression of CIDEB mRNA CTD PMID:17497460 NCBI chr15:29,252,203...29,256,759
Ensembl chr15:29,252,213...29,256,605 		JBrowse link
G Clcnka chloride voltage-gated channel Ka decreases expression EXP Furosemide results in decreased expression of CLCNKA mRNA CTD PMID:12759757 NCBI chr 5:153,691,208...153,706,295
Ensembl chr 5:153,691,209...153,706,148 		JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain decreases expression EXP Furosemide results in decreased expression of COL18A1 mRNA CTD PMID:16526316 NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593 		JBrowse link
G Cradd CASP2 and RIPK1 domain containing adaptor with death domain affects expression EXP Furosemide affects the expression of CRADD mRNA CTD PMID:17497460 NCBI chr 7:29,940,240...29,952,907
Ensembl chr 7:29,798,586...29,952,907 		JBrowse link
G Csf3 colony stimulating factor 3 increases expression EXP Furosemide results in increased expression of CSF3 mRNA CTD PMID:16526316 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603 		JBrowse link
G Dapk2 death-associated protein kinase 2 affects expression EXP Furosemide affects the expression of DAPK2 mRNA CTD PMID:17497460 NCBI chr 8:66,706,536...66,825,567
Ensembl chr 8:66,706,609...66,825,567 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Furosemide results in increased expression of DDIT3 mRNA CTD PMID:24813929 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dffa DNA fragmentation factor subunit alpha affects expression EXP Furosemide affects the expression of DFFA mRNA CTD PMID:17497460 NCBI chr 5:159,540,718...159,553,639
Ensembl chr 5:159,540,715...159,553,633 		JBrowse link
G Efna5 ephrin A5 increases expression EXP Furosemide results in increased expression of EFNA5 mRNA CTD PMID:16526316 NCBI chr 9:102,316,753...102,595,480
Ensembl chr 9:102,320,295...102,597,413 		JBrowse link
G Fadd Fas associated via death domain affects expression EXP Furosemide affects the expression of FADD mRNA CTD PMID:17497460 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Faslg Fas ligand affects expression EXP Furosemide affects the expression of FASLG mRNA CTD PMID:17497460 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fgf16 fibroblast growth factor 16 affects expression EXP Furosemide affects the expression of FGF16 mRNA CTD PMID:16526316 NCBI chr  X:70,816,658...70,827,270
Ensembl chr  X:70,817,433...70,878,717 		JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression EXP Furosemide results in decreased expression of FGF2 mRNA CTD PMID:16526316 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fgf4 fibroblast growth factor 4 increases expression EXP Furosemide results in increased expression of FGF4 mRNA CTD PMID:16526316 NCBI chr 1:200,023,937...200,027,793
Ensembl chr 1:200,024,056...200,025,466 		JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 affects expression EXP Furosemide affects the expression of FGFR4 mRNA CTD PMID:16526316 NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 increases expression EXP Furosemide results in increased expression of FLT1 mRNA CTD PMID:16526316 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions		 ISO
EXP		 Furosemide results in increased expression of FOS protein
Losartan inhibits the reaction [Furosemide results in increased expression of FOS protein]		 CTD PMID:10760498 PMID:15528393 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity EXP Furosemide results in decreased activity of G6PD protein CTD PMID:26820767 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 decreases activity EXP Furosemide results in decreased activity of GABRA4 protein CTD PMID:15613639 NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844 		JBrowse link
G Gad1 glutamate decarboxylase 1 decreases expression EXP Furosemide results in decreased expression of GAD1 mRNA CTD PMID:14596865 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha affects expression EXP Furosemide affects the expression of GADD45A mRNA CTD PMID:17497460 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions EXP [Drinking Water deficiency co-treated with Furosemide co-treated with iodixanol] results in decreased expression of GCLM mRNA; [Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in decreased expression of GCLM mRNA CTD PMID:29860548 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP Furosemide results in decreased activity of GSR protein CTD PMID:26820767 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP [Drinking Water deficiency co-treated with Furosemide co-treated with iodixanol] results in increased expression of HMGB1 protein; [Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in increased expression of HMGB1 protein CTD PMID:29860548 NCBI chr12:5,973,062...5,978,565
Ensembl chr12:5,901,586...5,978,565 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO
EXP		 Furosemide results in increased expression of HMOX1 mRNA
[Drinking Water deficiency co-treated with Furosemide co-treated with iodixanol] results in increased expression of HMOX1 mRNA; [Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in increased expression of HMOX1 mRNA		 CTD PMID:24813929 PMID:29860548 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hrk harakiri, BCL2 interacting protein affects expression EXP Furosemide affects the expression of HRK mRNA CTD PMID:17497460 NCBI chr12:38,387,484...38,409,652 JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases activity EXP Furosemide results in decreased activity of HSD11B1 protein CTD PMID:11749789 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687 		JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO Furosemide results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Hus1 HUS1 checkpoint clamp component affects expression EXP Furosemide affects the expression of HUS1 mRNA CTD PMID:17497460 NCBI chr14:83,688,702...83,703,466
Ensembl chr14:83,688,708...83,703,442 		JBrowse link
G Id1 inhibitor of DNA binding 1 decreases expression EXP Furosemide results in decreased expression of ID1 mRNA CTD PMID:16526316 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419 		JBrowse link
G Id3 inhibitor of DNA binding 3 decreases expression EXP Furosemide results in decreased expression of ID3 mRNA CTD PMID:16526316 NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349 		JBrowse link
G Ifna1 interferon, alpha 1 increases expression EXP Furosemide results in increased expression of IFNA1 mRNA CTD PMID:16526316 NCBI chr 5:103,095,767...103,098,260
Ensembl chr 5:103,097,356...103,097,925 		JBrowse link
G Igf1 insulin-like growth factor 1 increases expression EXP Furosemide results in increased expression of IGF1 mRNA CTD PMID:16526316 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il10 interleukin 10 decreases secretion ISO Furosemide results in decreased secretion of IL10 protein CTD PMID:16612254 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il6 interleukin 6 decreases secretion ISO Furosemide results in decreased secretion of IL6 protein CTD PMID:16612254 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itga5 integrin subunit alpha 5 decreases expression EXP Furosemide results in decreased expression of ITGA5 mRNA CTD PMID:16526316 NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837 		JBrowse link
G Kdr kinase insert domain receptor increases expression EXP Furosemide results in increased expression of KDR mRNA CTD PMID:16526316 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Lta lymphotoxin alpha affects expression EXP Furosemide affects the expression of LTA mRNA CTD PMID:17497460 NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859 		JBrowse link
G Ltb lymphotoxin beta affects expression EXP Furosemide affects the expression of LTB mRNA CTD PMID:17497460 NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381 		JBrowse link
G Ltbr lymphotoxin beta receptor affects expression EXP Furosemide affects the expression of LTBR mRNA CTD PMID:17497460 NCBI chr 4:158,108,884...158,115,339
Ensembl chr 4:158,108,886...158,121,539 		JBrowse link
G Mdk midkine increases expression EXP Furosemide results in increased expression of MDK mRNA CTD PMID:16526316 NCBI chr 3:77,901,156...77,903,997
Ensembl chr 3:77,901,158...77,903,130 		JBrowse link
G Mdm2 MDM2 proto-oncogene affects expression EXP Furosemide affects the expression of MDM2 mRNA CTD PMID:17497460 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Msr1 macrophage scavenger receptor 1 increases expression EXP Furosemide results in increased expression of MSR1 mRNA CTD PMID:16526316 NCBI chr16:52,717,775...52,802,890
Ensembl chr16:52,717,732...52,799,676 		JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 affects expression EXP Furosemide affects the expression of NAIP2 mRNA CTD PMID:17497460 NCBI chr 2:31,507,423...31,559,098
Ensembl chr 2:31,507,424...31,570,542 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases localization
decreases response to substance		 ISO Furosemide results in increased localization of NFE2L2 protein
NFE2L2 protein results in decreased susceptibility to Furosemide		 CTD PMID:18078705 PMID:24813929 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP [Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in increased expression of NLRP3 protein CTD PMID:29860548 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nol3 nucleolar protein 3 affects expression EXP Furosemide affects the expression of NOL3 mRNA CTD PMID:17497460 NCBI chr19:33,154,061...33,158,250
Ensembl chr19:33,154,062...33,158,250 		JBrowse link
G Nos3 nitric oxide synthase 3 affects expression EXP Furosemide affects the expression of NOS3 mRNA CTD PMID:16526316 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nppa natriuretic peptide A decreases expression ISO Furosemide results in decreased expression of NPPA protein CTD PMID:2146706 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP [Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in decreased expression of NQO1 mRNA CTD PMID:29860548 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Pdgfra platelet derived growth factor receptor alpha affects expression EXP Furosemide affects the expression of PDGFRA mRNA CTD PMID:16526316 NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta increases expression EXP Furosemide results in increased expression of PDGFRB mRNA CTD PMID:16526316 NCBI chr18:54,500,002...54,538,843
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 increases expression EXP Furosemide results in increased expression of PECAM1 mRNA CTD PMID:16526316 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Pf4 platelet factor 4 decreases expression EXP Furosemide results in decreased expression of PF4 mRNA CTD PMID:16526316 NCBI chr14:17,298,438...17,299,148
Ensembl chr14:17,298,308...17,299,365 		JBrowse link
G Pgd phosphogluconate dehydrogenase decreases activity EXP Furosemide results in decreased activity of PGD protein CTD PMID:26820767 NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778 		JBrowse link
G Pgf placental growth factor decreases expression EXP Furosemide results in decreased expression of PGF mRNA CTD PMID:16526316 NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685 		JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions EXP [Drinking Water deficiency co-treated with Furosemide co-treated with iodixanol] results in increased expression of PINK1 protein CTD PMID:29860548 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions EXP [Drinking Water deficiency co-treated with Furosemide co-treated with iodixanol] results in increased expression of PRKN protein CTD PMID:29860548 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Ptger4 prostaglandin E receptor 4 multiple interactions ISO PTGER4 protein affects the reaction [Furosemide results in increased expression of REN mRNA]; PTGER4 protein affects the reaction [Furosemide results in increased expression of REN protein] CTD PMID:15976003 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 affects expression EXP Furosemide affects the expression of PTGS1 mRNA; Furosemide affects the expression of PTGS1 protein CTD PMID:11961000 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 affects expression
multiple interactions
increases expression		 EXP Furosemide affects the expression of PTGS2 mRNA; Furosemide affects the expression of PTGS2 protein
[Furosemide results in increased expression of PTGS2 mRNA] which results in increased abundance of Prostaglandins; [rofecoxib results in decreased activity of PTGS2 protein] inhibits the reaction [Furosemide results in increased abundance of Prostaglandins]
Furosemide results in increased expression of PTGS2 mRNA; Furosemide results in increased expression of PTGS2 protein		 CTD PMID:11135058 PMID:11703585 PMID:11961000 PMID:19031110 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pth parathyroid hormone increases expression
multiple interactions		 EXP Furosemide results in increased expression of PTH protein
NPS R-467 inhibits the reaction [Furosemide results in increased expression of PTH protein]		 CTD PMID:15086907 NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530 		JBrowse link
G Ptn pleiotrophin affects expression EXP Furosemide affects the expression of PTN mRNA CTD PMID:16526316 NCBI chr 4:65,293,731...65,375,572
Ensembl chr 4:65,293,734...65,375,456 		JBrowse link
G Ren renin multiple interactions
increases expression
increases secretion
increases activity		 ISO
EXP		 Furosemide inhibits the reaction [Ethinyl Estradiol results in increased expression of REN protein]; Indomethacin inhibits the reaction [Furosemide results in increased expression of REN protein]; Ketoprofen inhibits the reaction [Furosemide results in increased activity of REN protein]; Sulindac inhibits the reaction [Furosemide results in increased expression of REN protein]
Furosemide results in increased secretion of REN protein
Furosemide results in increased expression of REN mRNA; Furosemide results in increased expression of REN protein
PTGER4 protein affects the reaction [Furosemide results in increased expression of REN mRNA]; PTGER4 protein affects the reaction [Furosemide results in increased expression of REN protein]		 CTD PMID:599795 PMID:1924052 PMID:3530574 PMID:4028619 PMID:7954537 More... NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 affects expression EXP Furosemide affects the expression of RIPK1 mRNA CTD PMID:17497460 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
G Rpa3 replication protein A3 affects expression EXP Furosemide affects the expression of RPA3 mRNA CTD PMID:17497460 NCBI chr 4:36,304,649...36,307,755
Ensembl chr 4:36,304,651...36,307,709 		JBrowse link
G S100b S100 calcium binding protein B multiple interactions EXP [Furosemide results in decreased activity of SLC12A2 protein] affects the reaction [Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein]]; [Furosemide results in decreased activity of SLC12A2 protein] inhibits the reaction [Ammonia results in increased secretion of S100B protein] CTD PMID:23880158 NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743 		JBrowse link
G S100g S100 calcium binding protein G affects expression ISO Furosemide affects the expression of S100G mRNA CTD PMID:17652376 NCBI chr  X:31,705,853...31,708,422
Ensembl chr  X:31,705,866...31,708,433 		JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 increases expression EXP Furosemide results in increased expression of S1PR1 mRNA CTD PMID:16526316 NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681 		JBrowse link
G Serpinb5 serpin family B member 5 increases expression EXP Furosemide results in increased expression of SERPINB5 mRNA CTD PMID:16526316 NCBI chr13:22,985,557...23,005,756
Ensembl chr13:22,985,557...23,005,756 		JBrowse link
G Serpinf1 serpin family F member 1 affects expression EXP Furosemide affects the expression of SERPINF1 mRNA CTD PMID:16526316 NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646 		JBrowse link
G Slc12a1 solute carrier family 12 member 1 decreases activity ISO Furosemide results in decreased activity of SLC12A1 protein CTD PMID:11249848 NCBI chr 3:112,406,140...112,482,913
Ensembl chr 3:112,406,140...112,482,899 		JBrowse link
G Slc12a2 solute carrier family 12 member 2 multiple interactions
decreases activity		 EXP
ISO		 [Furosemide results in decreased activity of SLC12A2 protein] affects the reaction [Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein]]; [Furosemide results in decreased activity of SLC12A2 protein] inhibits the reaction [Ammonia results in increased secretion of S100B protein]; [Furosemide results in decreased activity of SLC12A2 protein] promotes the reaction [Thioctic Acid results in decreased activity of Ammonia]; [Furosemide results in decreased activity of SLC12A2 protein] which results in decreased susceptibility to Ammonia; [Furosemide results in decreased activity of SLC12A2 protein] which results in increased activity of Ammonia
Furosemide inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium]		 CTD PMID:23880158 PMID:29959396 NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440 		JBrowse link
G Slc12a5 solute carrier family 12 member 5 decreases activity
multiple interactions		 EXP
ISO		 Furosemide results in decreased activity of SLC12A5 protein
Furosemide inhibits the reaction [SLC12A5 protein results in increased import of Thallium]		 CTD PMID:18094240 PMID:20086212 NCBI chr 3:153,696,522...153,735,801
Ensembl chr 3:153,696,517...153,735,765 		JBrowse link
G Slc12a7 solute carrier family 12 member 7 decreases activity ISO Furosemide results in decreased activity of SLC12A7 protein CTD PMID:10913127 NCBI chr 1:29,472,692...29,554,246
Ensembl chr 1:29,472,692...29,554,302 		JBrowse link
G Slc22a25 solute carrier family 22, member 25 multiple interactions EXP Furosemide inhibits the reaction [SLC22A19 protein affects the transport of estrone sulfate] CTD PMID:16079298 NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 increases expression
increases secretion
decreases activity		 EXP
ISO		 Furosemide results in increased expression of SLC22A6 protein
SLC22A6 protein results in increased secretion of Furosemide
Furosemide results in decreased activity of SLC22A6 protein		 CTD PMID:12897087 PMID:18216144 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions ISO Furosemide inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline] CTD PMID:15901346 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases activity
multiple interactions
increases secretion		 ISO
EXP		 Furosemide results in decreased activity of SLC22A8 protein
Furosemide inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]
Furosemide inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]
SLC22A8 protein results in increased secretion of Furosemide		 CTD PMID:10224140 PMID:11306713 PMID:18216144 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Slc26a4 solute carrier family 26 member 4 multiple interactions
affects localization		 EXP [Furosemide co-treated with Amiloride] affects the localization of SLC26A4 protein
Furosemide affects the localization of SLC26A4 protein		 CTD PMID:17311909 NCBI chr 6:48,107,575...48,153,762
Ensembl chr 6:48,107,588...48,145,703 		JBrowse link
G Sparc secreted protein acidic and cysteine rich increases expression EXP Furosemide results in increased expression of SPARC mRNA CTD PMID:16526316 NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396 		JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 increases expression EXP Furosemide results in increased expression of SPINK1 mRNA CTD PMID:28138970 NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP [Drinking Water deficiency co-treated with Furosemide] results in increased expression of SQSTM1 protein; iodixanol inhibits the reaction [[Drinking Water deficiency co-treated with Furosemide] results in increased expression of SQSTM1 protein]; Iohexol inhibits the reaction [[Drinking Water deficiency co-treated with Furosemide] results in increased expression of SQSTM1 protein] CTD PMID:29860548 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Tek TEK receptor tyrosine kinase increases expression EXP Furosemide results in increased expression of TEK mRNA CTD PMID:16526316 NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804 		JBrowse link
G Tgfa transforming growth factor alpha increases expression EXP Furosemide results in increased expression of TGFA mRNA CTD PMID:16526316 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 affects expression EXP Furosemide affects the expression of TGFB1 protein CTD PMID:18001696 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression EXP Furosemide results in increased expression of TGFB2 mRNA CTD PMID:16526316 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 increases expression EXP Furosemide results in increased expression of TGFBR1 mRNA CTD PMID:16526316 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 increases expression EXP Furosemide results in increased expression of TGFBR2 mRNA CTD PMID:16526316 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
G Thbs1 thrombospondin 1 affects expression EXP Furosemide affects the expression of THBS1 mRNA CTD PMID:16526316 NCBI chr 3:105,056,286...105,071,445
Ensembl chr 3:105,056,292...105,071,440 		JBrowse link
G Thbs2 thrombospondin 2 increases expression EXP Furosemide results in increased expression of THBS2 mRNA CTD PMID:16526316 NCBI chr 1:55,670,394...55,699,789
Ensembl chr 1:55,670,394...55,699,789 		JBrowse link
G Thbs3 thrombospondin 3 affects expression EXP Furosemide affects the expression of THBS3 mRNA CTD PMID:16526316 NCBI chr 2:174,621,788...174,633,594
Ensembl chr 2:174,621,812...174,633,594 		JBrowse link
G Thbs4 thrombospondin 4 affects expression EXP Furosemide affects the expression of THBS4 mRNA CTD PMID:16526316 NCBI chr 2:23,983,158...24,025,289
Ensembl chr 2:23,983,158...24,026,313 		JBrowse link
G Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 increases expression EXP Furosemide results in increased expression of TIE1 mRNA CTD PMID:16526316 NCBI chr 5:132,000,013...132,019,658
Ensembl chr 5:132,000,015...132,019,592 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 affects expression EXP Furosemide affects the expression of TIMP2 mRNA CTD PMID:16526316 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
G Tnf tumor necrosis factor decreases secretion
affects expression		 ISO
EXP		 Furosemide results in decreased secretion of TNF protein
Furosemide affects the expression of TNF mRNA		 CTD PMID:16526316 PMID:16612254 PMID:17497460 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf11a TNF receptor superfamily member 11A affects expression EXP Furosemide affects the expression of TNFRSF11A mRNA CTD PMID:17497460 NCBI chr13:21,928,370...21,986,719
Ensembl chr13:21,928,408...21,986,695 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A affects expression EXP Furosemide affects the expression of TNFRSF1A mRNA CTD PMID:17497460 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B affects expression EXP Furosemide affects the expression of TNFRSF1B mRNA CTD PMID:17497460 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206 		JBrowse link
G Tnfrsf25 TNF receptor superfamily member 25 affects expression EXP Furosemide affects the expression of TNFRSF25 mRNA CTD PMID:17497460 NCBI chr 5:162,621,669...162,626,341
Ensembl chr 5:162,622,075...162,626,341 		JBrowse link
G Tnfrsf8 TNF receptor superfamily member 8 affects expression EXP Furosemide affects the expression of TNFRSF8 mRNA CTD PMID:17497460 NCBI chr 5:157,123,183...157,168,421
Ensembl chr 5:157,123,185...157,168,421 		JBrowse link
G Tnfrsf9 TNF receptor superfamily member 9 affects expression EXP Furosemide affects the expression of TNFRSF9 mRNA CTD PMID:17497460 NCBI chr 5:161,381,662...161,408,003
Ensembl chr 5:161,381,662...161,408,000 		JBrowse link
G Tnfsf10 TNF superfamily member 10 affects expression EXP Furosemide affects the expression of TNFSF10 mRNA CTD PMID:17497460 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Tnfsf11 TNF superfamily member 11 affects expression EXP Furosemide affects the expression of TNFSF11 mRNA CTD PMID:17497460 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Tnfsf12 TNF superfamily member 12 affects expression EXP Furosemide affects the expression of TNFSF12 mRNA CTD PMID:17497460 NCBI chr10:54,403,870...54,413,213
Ensembl chr10:54,403,870...54,413,213 		JBrowse link
G Tnfsf13 TNF superfamily member 13 affects expression EXP Furosemide affects the expression of TNFSF13 mRNA CTD PMID:17497460 NCBI chr10:54,400,054...54,403,723
Ensembl chr10:54,400,065...54,403,042 		JBrowse link
G Tnfsf8 TNF superfamily member 8 affects expression EXP Furosemide affects the expression of TNFSF8 mRNA CTD PMID:17497460 NCBI chr 5:77,253,881...77,277,078
Ensembl chr 5:77,251,373...77,277,421 		JBrowse link
G Tnfsf9 TNF superfamily member 9 affects expression EXP Furosemide affects the expression of TNFSF9 mRNA CTD PMID:17497460 NCBI chr 9:1,944,017...1,946,351
Ensembl chr 9:1,944,017...1,946,345 		JBrowse link
G Tpmt thiopurine S-methyltransferase decreases activity ISO Furosemide results in decreased activity of TPMT protein CTD PMID:8866635 NCBI chr17:17,644,088...17,662,709
Ensembl chr17:17,644,173...17,662,709 		JBrowse link
G Traf5 TNF receptor-associated factor 5 affects expression EXP Furosemide affects the expression of TRAF5 mRNA CTD PMID:17497460 NCBI chr13:103,569,944...103,618,756
Ensembl chr13:103,572,314...103,618,709 		JBrowse link
G Traf6 TNF receptor associated factor 6 affects expression EXP Furosemide affects the expression of TRAF6 mRNA CTD PMID:17497460 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Trpv5 transient receptor potential cation channel, subfamily V, member 5 increases expression ISO Furosemide results in increased expression of TRPV5 mRNA; Furosemide results in increased expression of TRPV5 protein CTD PMID:17652376 NCBI chr 4:70,536,432...70,562,743
Ensembl chr 4:70,536,440...70,562,745 		JBrowse link
G Trpv6 transient receptor potential cation channel, subfamily V, member 6 increases expression ISO Furosemide results in increased expression of TRPV6 mRNA CTD PMID:17652376 NCBI chr 4:70,507,347...70,523,013
Ensembl chr 4:70,507,348...70,523,017 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO Furosemide results in increased expression of UGT1A1 mRNA CTD PMID:18227147 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Furosemide CTD PMID:15117964 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression EXP Furosemide results in increased expression of VCAM1 mRNA CTD PMID:16526316 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vegfa vascular endothelial growth factor A affects expression EXP Furosemide affects the expression of VEGFA mRNA CTD PMID:16526316 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vegfc vascular endothelial growth factor C increases expression EXP Furosemide results in increased expression of VEGFC mRNA CTD PMID:16526316 NCBI chr16:37,712,408...37,827,657
Ensembl chr16:37,712,262...37,827,848 		JBrowse link
G Xiap X-linked inhibitor of apoptosis affects expression EXP Furosemide affects the expression of XIAP mRNA CTD PMID:17497460 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
N-(2,6-diethylphenyl)-2-chloroacetamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases chemical synthesis
multiple interactions
increases abundance		 ISO CYP3A4 protein results in increased chemical synthesis of 2-chloro-N-(2,6-diethylphenyl)acetamide
[CYP3A4 protein results in increased metabolism of alachlor] which results in increased abundance of 2-chloro-N-(2,6-diethylphenyl)acetamide
CYP3A4 protein results in increased abundance of 2-chloro-N-(2,6-diethylphenyl)acetamide		 CTD PMID:10475613 PMID:18273908 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
niclosamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha decreases expression ISO Niclosamide results in decreased expression of ACACA mRNA CTD PMID:22576131 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ACP5 mRNA]		 CTD PMID:26792726 PMID:28824321 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression ISO Niclosamide results in decreased expression of ACSL1 mRNA CTD PMID:22576131 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO Niclosamide inhibits the reaction [Doxorubicin results in increased expression of ACTA2 protein]
Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of ACTA2 protein]		 CTD PMID:26643609 PMID:28318631 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide decreases expression ISO Niclosamide results in decreased expression of ADH4 mRNA CTD PMID:28284560 NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591 		JBrowse link
G Afp alpha-fetoprotein multiple interactions EXP Niclosamide inhibits the reaction [Thioacetamide results in increased expression of AFP protein]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of AFP protein]] CTD PMID:32961231 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases cleavage ISO Niclosamide results in increased cleavage of AIFM1 protein CTD PMID:22576131 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases expression
multiple interactions		 ISO Niclosamide results in increased expression of AKT1 mRNA
Niclosamide inhibits the reaction [TNF protein results in increased activity of AKT1 protein]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased phosphorylation of AKT1 protein]		 CTD PMID:20215516 PMID:26792726 PMID:29843133 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression ISO Niclosamide results in decreased expression of ALDH1A1 protein CTD PMID:24736023 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Aldob aldolase, fructose-bisphosphate B increases expression ISO Niclosamide results in increased expression of ALDOB mRNA CTD PMID:22576131 NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116 		JBrowse link
G Aldoc aldolase, fructose-bisphosphate C decreases expression ISO Niclosamide results in decreased expression of ALDOC mRNA CTD PMID:22576131 NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066 		JBrowse link
G Alox12b arachidonate 12-lipoxygenase, 12R type increases expression
multiple interactions
decreases response to substance		 ISO Niclosamide results in increased expression of ALOX12B mRNA
TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX12B mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX12B mRNA]
ALOX12B protein results in decreased susceptibility to Niclosamide		 CTD PMID:30258081 NCBI chr10:53,863,060...53,874,938
Ensembl chr10:53,863,060...53,874,938 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions
decreases response to substance
increases expression		 ISO TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX5 mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX5 mRNA]
ALOX5 protein results in decreased susceptibility to Niclosamide		 CTD PMID:30258081 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated decreases expression ISO Niclosamide results in decreased expression of ALPL mRNA CTD PMID:28824321 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Apof apolipoprotein F decreases expression ISO Niclosamide results in decreased expression of APOF mRNA CTD PMID:28284560 NCBI chr 7:700,688...702,130
Ensembl chr 7:700,762...701,946 		JBrowse link
G Ar androgen receptor multiple interactions
decreases expression		 ISO [enzalutamide co-treated with Niclosamide] results in decreased expression of AR protein; [Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]] which results in decreased expression of KLK3 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Niclosamide results in decreased expression of and results in increased degradation of AR protein alternative form]; bicalutamide promotes the reaction [Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]]; bicalutamide promotes the reaction [Niclosamide results in decreased expression of AR protein alternative form]; bicalutamide promotes the reaction [Niclosamide results in decreased expression of AR protein]; Niclosamide inhibits the reaction [AR protein alternative form binds to KLK3 promoter]; Niclosamide inhibits the reaction [AR protein alternative form results in decreased susceptibility to enzalutamide]; Niclosamide inhibits the reaction [AR protein alternative form results in increased expression of KLK3 mRNA]; Niclosamide inhibits the reaction [AR protein alternative form results in increased expression of KLK3 protein]; Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]; Niclosamide inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Niclosamide results in decreased expression of and results in increased degradation of AR protein alternative form
Niclosamide results in decreased expression of AR protein; Niclosamide results in decreased expression of AR protein alternative form		 CTD PMID:24740322 PMID:25970160 PMID:28500234 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Araf A-Raf proto-oncogene, serine/threonine kinase decreases expression ISO Niclosamide analog results in decreased expression of ARAF protein; Niclosamide results in decreased expression of ARAF protein CTD PMID:28284560 NCBI chr  X:1,227,392...1,292,356
Ensembl chr  X:1,227,392...1,239,073 		JBrowse link
G Asf1b anti-silencing function 1B histone chaperone decreases expression ISO Niclosamide results in decreased expression of ASF1B mRNA CTD PMID:28284560 NCBI chr19:24,181,024...24,195,604
Ensembl chr19:24,181,028...24,195,549 		JBrowse link
G Atf3 activating transcription factor 3 increases expression
multiple interactions		 ISO Niclosamide results in increased expression of ATF3 mRNA; Niclosamide results in increased expression of ATF3 protein
ATF3 protein affects the reaction [Niclosamide results in increased cleavage of CASP3 protein]; ATF3 protein affects the reaction [Niclosamide results in increased expression of DDIT3 mRNA]; ATF3 protein affects the reaction [Niclosamide results in increased expression of EIF2AK3 mRNA]		 CTD PMID:26917416 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO Niclosamide results in increased expression of ATF4 mRNA; Niclosamide results in increased expression of ATF4 protein CTD PMID:26917416 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha increases expression ISO Niclosamide results in increased expression of ATP5F1A mRNA CTD PMID:22576131 NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794 		JBrowse link
G Atp5f1d ATP synthase F1 subunit delta increases expression ISO Niclosamide results in increased expression of ATP5F1D mRNA CTD PMID:22576131 NCBI chr 7:9,560,604...9,565,919
Ensembl chr 7:9,560,608...9,565,929 		JBrowse link
G Atp5mc3 ATP synthase membrane subunit c locus 3 decreases expression ISO Niclosamide results in decreased expression of ATP5MC3 mRNA CTD PMID:22576131 NCBI chr 3:58,810,535...58,813,185
Ensembl chr 3:58,810,535...58,814,279 		JBrowse link
G Atp5mf ATP synthase membrane subunit f decreases expression ISO Niclosamide results in decreased expression of ATP5MF mRNA CTD PMID:22576131 NCBI chr12:9,421,665...9,428,236
Ensembl chr12:9,421,579...9,428,236 		JBrowse link
G Atp5mg ATP synthase membrane subunit g decreases expression ISO Niclosamide results in decreased expression of ATP5MG mRNA CTD PMID:22576131 NCBI chr 8:45,226,750...45,233,582
Ensembl chr 8:45,225,686...45,233,559 		JBrowse link
G Atp5pb ATP synthase peripheral stalk-membrane subunit b decreases expression ISO Niclosamide results in decreased expression of ATP5PB mRNA CTD PMID:22576131 NCBI chr 2:193,424,138...193,435,418
Ensembl chr 2:193,424,047...193,435,418 		JBrowse link
G Atp6ap1 ATPase H+ transporting accessory protein 1 decreases expression ISO Niclosamide results in decreased expression of ATP6AP1 mRNA CTD PMID:22576131 NCBI chr  X:152,079,954...152,087,034
Ensembl chr  X:152,079,865...152,087,034 		JBrowse link
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 multiple interactions ISO Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ATP6V0D2 mRNA] CTD PMID:26792726 NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354 		JBrowse link
G Aurkb aurora kinase B decreases expression ISO Niclosamide results in decreased expression of AURKB mRNA CTD PMID:28284560 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837 		JBrowse link
G Axin2 axin 2 multiple interactions
decreases expression		 ISO Niclosamide inhibits the reaction [Lithium Chloride results in increased expression of AXIN2 mRNA]
Niclosamide results in decreased expression of AXIN2 mRNA; Niclosamide results in decreased expression of AXIN2 protein		 CTD PMID:22576131 PMID:24534281 PMID:24552774 PMID:24736023 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO [Niclosamide binds to Polyethyleneimine] which results in increased expression of BAD mRNA CTD PMID:25988281 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO [Niclosamide binds to Polyethyleneimine] which results in increased expression of BAK1 mRNA CTD PMID:25988281 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
decreases expression		 ISO Niclosamide results in increased expression of BAX protein
[Niclosamide binds to Polyethyleneimine] which results in increased expression of BAX mRNA; [Niclosamide co-treated with bicalutamide] results in increased expression of BAX protein; bicalutamide inhibits the reaction [Niclosamide results in decreased expression of BAX protein]		 CTD PMID:25634333 PMID:25988281 PMID:26703449 PMID:28500234 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions
increases expression		 ISO TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of BBC3 mRNA] CTD PMID:30258081 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO Niclosamide analog results in decreased expression of BCL2 protein; Niclosamide results in decreased expression of BCL2 protein
[Niclosamide binds to Polyethyleneimine] which results in decreased expression of BCL2 mRNA; [Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2 protein]] which results in increased susceptibility to Erlotinib Hydrochloride; bicalutamide promotes the reaction [Niclosamide results in decreased expression of BCL2 protein]; Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2 protein]; Niclosamide inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; Niclosamide promotes the reaction [bicalutamide results in decreased expression of BCL2 protein]		 CTD PMID:20215516 PMID:23894143 PMID:25634333 PMID:25988281 PMID:26116531 More... NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression		 ISO [Niclosamide binds to Polyethyleneimine] which results in decreased expression of BCL2L1 mRNA; bicalutamide promotes the reaction [Niclosamide results in decreased expression of BCL2L1 protein]; Niclosamide inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA]; Niclosamide promotes the reaction [bicalutamide results in decreased expression of BCL2L1 protein]
Niclosamide analog results in decreased expression of BCL2L1 protein; Niclosamide results in decreased expression of BCL2L1 protein		 CTD PMID:20215516 PMID:25988281 PMID:26116531 PMID:28284560 PMID:28500234 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bcl2l2 Bcl2-like 2 decreases expression
multiple interactions		 ISO Niclosamide results in decreased expression of BCL2L2 protein
[Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L2 protein]] which results in increased susceptibility to Erlotinib Hydrochloride; Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L2 protein]		 CTD PMID:23894143 NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624 		JBrowse link
G Bcl6 BCL6, transcription repressor multiple interactions ISO Niclosamide affects the reaction [FAS protein mutant form affects the expression of BCL6 mRNA]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of BCL6 protein] CTD PMID:33632240 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
G Bcl9 BCL9, transcription coactivator decreases expression EXP Niclosamide results in decreased expression of BCL9 mRNA CTD PMID:27338550 NCBI chr 2:184,760,616...184,846,261
Ensembl chr 2:184,760,618...184,786,435 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
affects expression
decreases expression		 ISO enzalutamide promotes the reaction [Niclosamide results in decreased expression of BIRC5 protein]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of BIRC5 protein]
Niclosamide affects the expression of BIRC5 protein
Niclosamide analog results in decreased expression of BIRC5 protein; Niclosamide results in decreased expression of BIRC5 protein		 CTD PMID:24552774 PMID:24736023 PMID:25970160 PMID:28284560 PMID:28500234 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase decreases expression
decreases phosphorylation		 ISO Niclosamide analog results in decreased expression of BRAF protein; Niclosamide results in decreased expression of BRAF protein
Niclosamide analog results in decreased phosphorylation of BRAF protein		 CTD PMID:28284560 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO [Niclosamide co-treated with Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CASP1 protein
Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased cleavage of CASP1 protein]		 CTD PMID:33524445 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
increases expression
decreases expression		 ISO
EXP		 Niclosamide results in increased cleavage of CASP3 protein
Niclosamide inhibits the reaction [Thioacetamide results in decreased expression of CASP3 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in decreased expression of CASP3 mRNA]]
[TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased expression of CASP3 protein modified form; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 protein modified form]
Niclosamide results in increased expression of CASP3 protein modified form
Niclosamide results in decreased expression of CASP3 protein
7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [Niclosamide results in increased cleavage of CASP3 protein]; [Niclosamide binds to Polyethyleneimine] which results in increased expression of CASP3 mRNA; ATF3 protein affects the reaction [Niclosamide results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Niclosamide results in increased cleavage of CASP3 protein]; TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of CASP3 protein]; WNT7A protein affects the reaction [Niclosamide results in increased cleavage of CASP3 protein]		 CTD PMID:20215516 PMID:21871175 PMID:24750999 PMID:25174399 PMID:25634333 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions
increases expression		 ISO bicalutamide promotes the reaction [Niclosamide results in increased expression of CASP7 protein modified form] CTD PMID:26116531 PMID:28500234 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
increases cleavage		 ISO TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of CASP9 protein]
Niclosamide results in increased expression of CASP9 protein modified form		 CTD PMID:26116531 PMID:26703449 PMID:30258081 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO
EXP		 Niclosamide inhibits the reaction [Doxorubicin results in increased expression of CCL2 mRNA]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of CCL2 mRNA]		 CTD PMID:24561310 PMID:28318631 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 multiple interactions ISO
EXP		 Niclosamide inhibits the reaction [Doxorubicin results in increased expression of CCL20 mRNA]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of CCL20 mRNA]		 CTD PMID:28318631 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein] CTD PMID:24561310 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL5 protein] CTD PMID:24561310 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Niclosamide results in decreased expression of CCNB1 mRNA CTD PMID:28284560 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression		 EXP
ISO		 Niclosamide inhibits the reaction [Epinephrine results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [GCG protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [GCG protein results in increased expression of CCND1 protein]; Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 protein]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 mRNA]]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 protein]]
Niclosamide results in decreased expression of CCND1 mRNA
Niclosamide analog results in decreased expression of CCND1 protein; Niclosamide results in decreased expression of CCND1 mRNA; Niclosamide results in decreased expression of CCND1 protein
Niclosamide inhibits the reaction [IL6 protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA]; Niclosamide promotes the reaction [bicalutamide results in decreased expression of CCND1 protein]		 CTD PMID:19160421 PMID:20215516 PMID:24552774 PMID:24736023 PMID:26297436 More... NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnd2 cyclin D2 decreases expression
increases expression		 ISO Niclosamide results in decreased expression of CCND2 mRNA
Niclosamide results in increased expression of CCND2 mRNA		 CTD PMID:22576131 PMID:27226553 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495 		JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO Niclosamide results in decreased expression of CCND3 mRNA CTD PMID:22576131 PMID:27226553 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371 		JBrowse link
G Ccne2 cyclin E2 multiple interactions ISO Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of CCNE2 mRNA] CTD PMID:27542212 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632 		JBrowse link
G Ccng2 cyclin G2 multiple interactions ISO Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CCNG2 mRNA] CTD PMID:27542212 NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830 		JBrowse link
G Cd40 CD40 molecule multiple interactions ISO Niclosamide inhibits the reaction [Lipopolysaccharides affects the expression of CD40 protein] CTD PMID:24561310 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cd80 Cd80 molecule multiple interactions ISO Niclosamide inhibits the reaction [Lipopolysaccharides affects the expression of CD80 protein] CTD PMID:24561310 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030 		JBrowse link
G Cd86 CD86 molecule multiple interactions ISO Niclosamide inhibits the reaction [Lipopolysaccharides affects the expression of CD86 protein] CTD PMID:24561310 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Cdc37 cell division cycle 37, HSP90 cochaperone multiple interactions ISO CDC37 protein binds to and results in increased susceptibility to Niclosamide analog CTD PMID:28284560 NCBI chr 8:19,677,400...19,690,761
Ensembl chr 8:19,671,938...19,690,809 		JBrowse link
G Cdc42 cell division cycle 42 decreases expression
decreases phosphorylation		 ISO Niclosamide results in decreased expression of CDC42 mRNA
Niclosamide results in decreased phosphorylation of CDC42 protein		 CTD PMID:29251334 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111 		JBrowse link
G Cdc6 cell division cycle 6 decreases expression ISO Niclosamide results in decreased expression of CDC6 mRNA CTD PMID:28284560 NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011 		JBrowse link
G Cdca2 cell division cycle associated 2 decreases expression ISO Niclosamide results in decreased expression of CDCA2 mRNA CTD PMID:28284560 NCBI chr15:41,895,946...41,942,226
Ensembl chr15:41,895,901...41,941,611 		JBrowse link
G Cdca5 cell division cycle associated 5 decreases expression ISO Niclosamide results in decreased expression of CDCA5 mRNA CTD PMID:28284560 NCBI chr 1:203,378,550...203,392,027
Ensembl chr 1:203,378,577...203,392,023 		JBrowse link
G Cdca8 cell division cycle associated 8 decreases expression ISO Niclosamide results in decreased expression of CDCA8 mRNA CTD PMID:28284560 NCBI chr 5:137,176,414...137,198,686
Ensembl chr 5:137,176,417...137,198,629 		JBrowse link
G Cdh1 cadherin 1 multiple interactions
increases expression		 ISO Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in decreased expression of CDH1 protein]; WNT7A protein affects the reaction [Niclosamide results in increased expression of CDH1 protein]
Niclosamide results in increased expression of CDH1 mRNA; Niclosamide results in increased expression of CDH1 protein		 CTD PMID:25174399 PMID:26643609 PMID:30143678 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of CDH2 protein] CTD PMID:26643609 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO Niclosamide results in decreased expression of CDK2 protein CTD PMID:29031202 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Niclosamide results in decreased expression of CDK4 protein CTD PMID:29031202 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression		 ISO TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of CDKN1A mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of CDKN1A mRNA] CTD PMID:30258081 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 decreases expression ISO Niclosamide results in decreased expression of CDKN3 mRNA CTD PMID:28284560 NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945 		JBrowse link
G Celsr3 cadherin, EGF LAG seven-pass G-type receptor 3 increases expression ISO Niclosamide results in increased expression of CELSR3 mRNA CTD PMID:28284560 NCBI chr 8:109,530,597...109,558,360
Ensembl chr 8:109,530,641...109,558,354 		JBrowse link
G Cenpa centromere protein A decreases expression ISO Niclosamide results in decreased expression of CENPA mRNA CTD PMID:28284560 NCBI chr 6:25,700,142...25,711,767
Ensembl chr 6:25,700,142...25,711,675 		JBrowse link
G Cfp complement factor properdin increases expression ISO Niclosamide results in increased expression of CFP mRNA CTD PMID:28284560 NCBI chr  X:1,162,014...1,167,576
Ensembl chr  X:1,161,979...1,167,573 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO Niclosamide results in decreased phosphorylation of and affects the localization of CHUK protein CTD PMID:26116531 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO Niclosamide results in decreased expression of COL1A1 mRNA CTD PMID:28824321 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Colec10 collectin subfamily member 10 increases expression ISO Niclosamide results in increased expression of COLEC10 mRNA CTD PMID:28284560 NCBI chr 7:85,744,895...85,806,368
Ensembl chr 7:85,744,895...85,805,675 		JBrowse link
G Crebbp CREB binding protein increases expression ISO Niclosamide results in increased expression of CREBBP mRNA CTD PMID:22576131 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Csf1 colony stimulating factor 1 multiple interactions ISO Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ACP5 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of and affects the localization of NFATC1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 protein modified form]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of FOS mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ITGB3 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MMP9 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFATC1 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OCSTAMP mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OSCAR mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of TRAF6 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK3 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK8 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK9 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of NFKBIA protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of RELA protein] CTD PMID:28824321 NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704 		JBrowse link
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 multiple interactions ISO Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CSGALNACT1 mRNA] CTD PMID:27542212 NCBI chr16:20,995,210...21,330,586
Ensembl chr16:21,235,784...21,330,319 		JBrowse link
G Csnk1e casein kinase 1, epsilon increases expression ISO Niclosamide results in increased expression of CSNK1E mRNA CTD PMID:22576131 NCBI chr 7:110,983,322...111,006,926
Ensembl chr 7:110,983,318...111,006,794 		JBrowse link
G Csrnp1 cysteine and serine rich nuclear protein 1 increases expression ISO Niclosamide results in increased expression of CSRNP1 mRNA CTD PMID:28284560 NCBI chr 8:119,704,712...119,717,767
Ensembl chr 8:119,704,713...119,718,183 		JBrowse link
G Ctbp1 C-terminal binding protein 1 increases expression ISO Niclosamide results in increased expression of CTBP1 mRNA CTD PMID:22576131 NCBI chr14:77,455,580...77,482,821
Ensembl chr14:77,455,696...77,482,821 		JBrowse link
G Ctnnb1 catenin beta 1 increases expression
decreases expression
increases ubiquitination
decreases activity
multiple interactions		 ISO
EXP		 Niclosamide results in increased expression of CTNNB1 mRNA
Niclosamide results in decreased expression of CTNNB1 mRNA
Niclosamide results in increased ubiquitination of CTNNB1 protein
Niclosamide results in decreased activity of CTNNB1 protein
Niclosamide inhibits the reaction [Epinephrine results in increased phosphorylation of CTNNB1 protein]; Niclosamide inhibits the reaction [GCG protein results in increased phosphorylation of CTNNB1 protein]; Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CTNNB1 protein]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CTNNB1 protein]]
Niclosamide analog results in decreased expression of CTNNB1 protein; Niclosamide results in decreased expression of CTNNB1 protein
Imatinib Mesylate promotes the reaction [Niclosamide results in decreased expression of CTNNB1 protein]; Niclosamide inhibits the reaction [CTNNB1 protein binds to CTNNBIP1 protein]; Niclosamide inhibits the reaction [Lithium Chloride affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [WNT3A protein affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [WNT3A protein results in increased stability of CTNNB1 protein]; Niclosamide promotes the reaction [Imatinib Mesylate results in decreased expression of CTNNB1 protein]		 CTD PMID:19772353 PMID:21531761 PMID:22576131 PMID:24534281 PMID:24552774 More... NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Ctnnbip1 catenin, beta-interacting protein 1 multiple interactions ISO Niclosamide inhibits the reaction [CTNNB1 protein binds to CTNNBIP1 protein] CTD PMID:24534281 NCBI chr 5:159,961,961...160,010,942
Ensembl chr 5:159,961,928...160,010,939 		JBrowse link
G Ctsc cathepsin C decreases expression ISO Niclosamide results in decreased expression of CTSC protein CTD PMID:29480568 NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387 		JBrowse link
G Ctsd cathepsin D decreases expression ISO Niclosamide results in decreased expression of CTSD protein CTD PMID:29480568 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488 		JBrowse link
G Ctsk cathepsin K multiple interactions ISO Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA] CTD PMID:26792726 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550 		JBrowse link
G Cxcr5 C-X-C motif chemokine receptor 5 multiple interactions ISO Niclosamide affects the reaction [FAS protein mutant form affects the expression of CXCR5 mRNA] CTD PMID:33632240 NCBI chr 8:44,842,098...44,858,425
Ensembl chr 8:44,843,413...44,857,893 		JBrowse link
G Cycs cytochrome c, somatic increases expression ISO Niclosamide results in increased expression of CYCS protein CTD PMID:26703449 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity ISO Niclosamide results in increased activity of CYP1A1 protein CTD PMID:12451431 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
increases expression		 ISO Niclosamide results in decreased activity of CYP1A2 protein
Niclosamide results in increased expression of CYP1A2 mRNA		 CTD PMID:11124226 PMID:28284560 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Niclosamide results in decreased activity of CYP2D6 protein CTD PMID:11124226 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp39a1 cytochrome P450, family 39, subfamily a, polypeptide 1 increases expression ISO Niclosamide results in increased expression of CYP39A1 mRNA CTD PMID:28284560 NCBI chr 9:17,230,455...17,306,775
Ensembl chr 9:17,230,455...17,306,775 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO Niclosamide results in decreased activity of CYP3A4 protein CTD PMID:11124226 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions		 ISO Niclosamide results in increased expression of DDIT3 mRNA; Niclosamide results in increased expression of DDIT3 protein
ATF3 protein affects the reaction [Niclosamide results in increased expression of DDIT3 mRNA]		 CTD PMID:26917416 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Decr1 2,4-dienoyl-CoA reductase 1 decreases expression ISO Niclosamide results in decreased expression of DECR1 mRNA CTD PMID:22576131 NCBI chr 5:29,411,172...29,439,054
Ensembl chr 5:29,411,172...29,439,018 		JBrowse link
G Dmac2l distal membrane arm assembly component 2 like decreases expression ISO Niclosamide results in decreased expression of DMAC2L mRNA CTD PMID:22576131 NCBI chr 6:88,205,580...88,223,934
Ensembl chr 6:88,205,700...88,223,933 		JBrowse link
G Dscc1 DNA replication and sister chromatid cohesion 1 multiple interactions ISO Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of DSCC1 mRNA] CTD PMID:27542212 NCBI chr 7:86,482,588...86,498,212
Ensembl chr 7:86,482,588...86,498,212 		JBrowse link
G Dvl1 dishevelled segment polarity protein 1 increases expression ISO Niclosamide results in increased expression of DVL1 mRNA CTD PMID:22576131 NCBI chr 5:166,456,989...166,468,733
Ensembl chr 5:166,456,686...166,468,664 		JBrowse link
G Dvl2 dishevelled segment polarity protein 2 decreases expression
multiple interactions		 ISO
EXP		 Niclosamide results in decreased expression of DVL2 protein
Niclosamide inhibits the reaction [Thioacetamide results in increased expression of DVL2 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of DVL2 mRNA]]		 CTD PMID:19772353 PMID:21531761 PMID:30143678 PMID:32961231 NCBI chr10:54,723,356...54,732,823
Ensembl chr10:54,723,411...54,732,820 		JBrowse link
G Dvl3 dishevelled segment polarity protein 3 increases expression ISO Niclosamide results in increased expression of DVL3 mRNA CTD PMID:22576131 NCBI chr11:80,365,446...80,382,641
Ensembl chr11:80,366,117...80,382,462 		JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO Niclosamide results in decreased expression of E2F1 mRNA CTD PMID:29843133 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G E2f8 E2F transcription factor 8 decreases expression ISO Niclosamide results in decreased expression of E2F8 mRNA CTD PMID:28284560 NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098 		JBrowse link
G Ebf1 EBF transcription factor 1 decreases expression ISO Niclosamide results in decreased expression of EBF1 mRNA CTD PMID:27226553 NCBI chr10:29,095,858...29,489,142
Ensembl chr10:29,099,933...29,487,665 		JBrowse link
G Echdc1 ethylmalonyl-CoA decarboxylase 1 decreases expression ISO Niclosamide results in decreased expression of ECHDC1 mRNA CTD PMID:22576131 NCBI chr 1:28,476,354...28,507,173
Ensembl chr 1:28,476,200...28,507,319 		JBrowse link
G Echs1 enoyl-CoA hydratase, short chain 1 decreases expression ISO Niclosamide results in decreased expression of ECHS1 mRNA CTD PMID:22576131 NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884 		JBrowse link
G Egf epidermal growth factor decreases expression
multiple interactions		 ISO Niclosamide results in decreased expression of EGF mRNA; Niclosamide results in decreased expression of EGF protein
Niclosamide inhibits the reaction [EGF protein results in increased expression of HIF1A mRNA]; Niclosamide inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein]		 CTD PMID:30779072 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor decreases expression
decreases phosphorylation		 ISO Niclosamide analog results in decreased expression of EGFR protein; Niclosamide results in decreased expression of EGFR mRNA; Niclosamide results in decreased expression of EGFR protein
Niclosamide results in decreased phosphorylation of EGFR protein		 CTD PMID:28284560 PMID:28426875 PMID:30779072 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Egr1 early growth response 1 increases expression ISO Niclosamide results in increased expression of EGR1 mRNA CTD PMID:28284560 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases expression
multiple interactions		 ISO Niclosamide results in increased expression of EIF2AK3 mRNA
ATF3 protein affects the reaction [Niclosamide results in increased expression of EIF2AK3 mRNA]; Niclosamide results in increased expression of and results in increased phosphorylation of EIF2AK3 protein		 CTD PMID:26917416 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO Niclosamide results in increased phosphorylation of EIF2S1 protein CTD PMID:26917416 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO Niclosamide promotes the reaction [EIF4E protein binds to EIF4EBP1 protein] CTD PMID:19771169 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases expression
multiple interactions
decreases phosphorylation		 ISO Niclosamide analog results in decreased expression of EIF4EBP1 protein modified form; Niclosamide results in decreased expression of EIF4EBP1 protein modified form
Niclosamide inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]; Niclosamide promotes the reaction [EIF4E protein binds to EIF4EBP1 protein]
Niclosamide results in decreased phosphorylation of EIF4EBP1 protein		 CTD PMID:19771169 PMID:28284560 PMID:30258081 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Endod1 endonuclease domain containing 1 multiple interactions ISO Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of ENDOD1 mRNA] CTD PMID:27542212 NCBI chr 8:11,209,123...11,238,680
Ensembl chr 8:11,211,110...11,238,892 		JBrowse link
G Eno2 enolase 2 increases expression ISO Niclosamide results in increased expression of ENO2 mRNA CTD PMID:22576131 NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980 		JBrowse link
G Eno3 enolase 3 decreases expression ISO Niclosamide results in decreased expression of ENO3 mRNA CTD PMID:22576131 NCBI chr10:55,370,531...55,375,921
Ensembl chr10:55,366,975...55,375,921 		JBrowse link
G Ep300 E1A binding protein p300 increases expression ISO Niclosamide results in increased expression of EP300 mRNA CTD PMID:22576131 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Eps8l3 EPS8 like 3 increases expression ISO Niclosamide results in increased expression of EPS8L3 mRNA CTD PMID:28284560 Ensembl chr 2:195,514,692...195,528,085 JBrowse link
G Fam83d family with sequence similarity 83, member D decreases expression ISO Niclosamide results in decreased expression of FAM83D mRNA CTD PMID:28284560 NCBI chr 3:147,421,941...147,441,211
Ensembl chr 3:147,421,908...147,441,192 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO
EXP		 Niclosamide affects the reaction [FAS protein mutant form affects the expression of BCL6 mRNA]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of BCL6 protein]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of CXCR5 mRNA]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of IL21 protein]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of IL6 protein]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of PRDM1 mRNA]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of TCF7 protein]; Niclosamide affects the reaction [FAS protein mutant form affects the phosphorylation of STAT3 protein]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of FAS mRNA]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FAS mRNA]		 CTD PMID:28318631 PMID:33632240 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fgf1 fibroblast growth factor 1 decreases expression ISO Niclosamide results in decreased expression of FGF1 mRNA; Niclosamide results in decreased expression of FGF1 protein CTD PMID:25174399 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357 		JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 multiple interactions
decreases expression		 ISO [Niclosamide co-treated with bicalutamide] results in decreased expression of FKBP5 mRNA
Niclosamide results in decreased expression of FKBP5 mRNA		 CTD PMID:28500234 NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO Niclosamide inhibits the reaction [Doxorubicin results in increased expression of FN1 protein]
HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]		 CTD PMID:28318631 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of FOS mRNA]
Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]		 CTD PMID:26792726 PMID:28824321 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression ISO Niclosamide results in increased expression of FOSB mRNA CTD PMID:28284560 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO Niclosamide results in increased expression of FOSL1 mRNA CTD PMID:22576131 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930 		JBrowse link
G Foxm1 forkhead box M1 multiple interactions
decreases expression		 ISO Imatinib Mesylate promotes the reaction [Niclosamide results in decreased expression of FOXM1 protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of FOXM1 protein]; Niclosamide promotes the reaction [Imatinib Mesylate results in decreased expression of FOXM1 protein] CTD PMID:27492973 NCBI chr 4:161,639,561...161,652,012
Ensembl chr 4:161,638,816...161,650,684 		JBrowse link
G Fscn1 fascin actin-bundling protein 1 multiple interactions ISO Niclosamide inhibits the reaction [Adenosine Triphosphate results in increased expression of FSCN1 mRNA] CTD PMID:29733962 NCBI chr12:11,597,042...11,610,183
Ensembl chr12:11,597,048...11,610,211 		JBrowse link
G Fzd1 frizzled class receptor 1 affects localization ISO Niclosamide affects the localization of FZD1 protein CTD PMID:19772353 NCBI chr 4:29,310,303...29,314,701
Ensembl chr 4:29,310,091...29,312,643
Ensembl chr 4:29,310,091...29,312,643 		JBrowse link
G Fzd2 frizzled class receptor 2 decreases expression ISO Niclosamide results in decreased expression of FZD2 mRNA CTD PMID:22576131 NCBI chr10:87,561,866...87,563,776
Ensembl chr10:87,561,326...87,565,334 		JBrowse link
G Fzd5 frizzled class receptor 5 increases expression ISO Niclosamide results in increased expression of FZD5 mRNA CTD PMID:22576131 NCBI chr 9:66,117,370...66,119,127
Ensembl chr 9:66,113,112...66,121,457 		JBrowse link
G Fzd9 frizzled class receptor 9 decreases expression ISO Niclosamide results in decreased expression of FZD9 mRNA CTD PMID:22576131 NCBI chr12:21,427,084...21,429,398
Ensembl chr12:21,427,084...21,429,398 		JBrowse link
G Gcg glucagon multiple interactions EXP Niclosamide inhibits the reaction [GCG protein results in increased abundance of Cyclic AMP]; Niclosamide inhibits the reaction [GCG protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [GCG protein results in increased expression of CCND1 protein]; Niclosamide inhibits the reaction [GCG protein results in increased expression of MYC mRNA]; Niclosamide inhibits the reaction [GCG protein results in increased phosphorylation of CTNNB1 protein] CTD PMID:26964897 NCBI chr 3:47,113,914...47,122,929
Ensembl chr 3:47,113,914...47,122,929 		JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 increases expression ISO Niclosamide results in increased expression of GOT2 mRNA CTD PMID:22576131 NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression
decreases phosphorylation		 ISO Niclosamide results in decreased expression of GSK3B mRNA
Niclosamide results in decreased phosphorylation of GSK3B protein		 CTD PMID:22576131 PMID:30143678 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gtse1 G-2 and S-phase expressed 1 decreases expression ISO Niclosamide results in decreased expression of GTSE1 mRNA CTD PMID:28284560 NCBI chr 7:116,949,997...116,966,826
Ensembl chr 7:116,950,053...116,966,806 		JBrowse link
G Hadh hydroxyacyl-CoA dehydrogenase decreases expression ISO Niclosamide results in decreased expression of HADH mRNA CTD PMID:22576131 NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353 		JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression
increases expression		 ISO Niclosamide results in decreased expression of HAMP mRNA
Niclosamide results in increased expression of HAMP mRNA		 CTD PMID:25633564 PMID:28284560 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891 		JBrowse link
G Hbp1 HMG-box transcription factor 1 multiple interactions ISO Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of HBP1 mRNA] CTD PMID:27542212 NCBI chr 6:48,529,633...48,555,775
Ensembl chr 6:48,529,372...48,555,787 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 decreases expression
multiple interactions		 ISO
EXP		 Niclosamide results in decreased expression of HES1 protein
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HES1 mRNA]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HES1 mRNA]; Niclosamide inhibits the reaction [Thioacetamide results in increased expression of HES1 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of HES1 mRNA]]		 CTD PMID:19160421 PMID:28318631 PMID:32961231 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192 		JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 multiple interactions ISO
EXP		 Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HEY1 mRNA]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HEY1 mRNA]
Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of HEY1 mRNA]		 CTD PMID:27542212 PMID:28318631 NCBI chr 2:93,096,706...93,100,316
Ensembl chr 2:93,095,498...93,100,312 		JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 multiple interactions
increases expression		 EXP
ISO		 Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HEY2 mRNA]
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HEY2 mRNA]
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Niclosamide results in increased expression of HEY2 mRNA]		 CTD PMID:19160421 PMID:28318631 NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression
multiple interactions		 ISO Niclosamide results in decreased expression of HIF1A mRNA; Niclosamide results in decreased expression of HIF1A protein
Niclosamide inhibits the reaction [EGF protein results in increased expression of HIF1A mRNA]		 CTD PMID:30779072 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hipk2 homeodomain interacting protein kinase 2 multiple interactions ISO
EXP		 Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HIPK2 mRNA]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HIPK2 protein]
HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]]; HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]]; HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]; Niclosamide inhibits the reaction [TGFB1 protein promotes the reaction [SMAD3 protein binds to HIPK2 promoter]]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 protein]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 protein]		 CTD PMID:28318631 NCBI chr 4:67,439,327...67,619,223
Ensembl chr 4:67,440,501...67,619,223 		JBrowse link
G Hmmr hyaluronan-mediated motility receptor decreases expression ISO Niclosamide results in decreased expression of HMMR mRNA CTD PMID:28284560 NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060 		JBrowse link
G Hoxa1 homeobox A1 increases expression ISO Niclosamide results in increased expression of HOXA1 CTD PMID:26820057 NCBI chr 4:81,255,814...81,258,504
Ensembl chr 4:81,255,883...81,258,504 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO
EXP		 Niclosamide inhibits the reaction [Doxorubicin results in increased expression of ICAM1 mRNA]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of ICAM1 mRNA]		 CTD PMID:28318631 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor affects response to substance ISO IGF1R protein affects the susceptibility to Niclosamide CTD PMID:27497986 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Iglc1 immunoglobulin lambda constant 1 decreases expression ISO Niclosamide results in decreased expression of IGLL1 mRNA CTD PMID:27226553 NCBI chr11:81,947,966...81,949,822
Ensembl chr11:81,947,934...81,949,822 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta affects localization ISO Niclosamide affects the localization of IKBKB protein CTD PMID:26116531 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma affects localization ISO Niclosamide affects the localization of IKBKG protein CTD PMID:26116531 NCBI chr  X:152,216,485...152,241,476
Ensembl chr  X:152,216,596...152,239,499 		JBrowse link
G Il12a interleukin 12A multiple interactions ISO Niclosamide inhibits the reaction [IL6 protein results in increased expression of IL12A mRNA] CTD PMID:26297436 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IL1B mRNA] CTD PMID:33524445 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il21 interleukin 21 multiple interactions ISO Niclosamide affects the reaction [FAS protein mutant form affects the expression of IL21 protein]; Niclosamide inhibits the reaction [resiquimod results in increased expression of IL21 protein] CTD PMID:33632240 NCBI chr 2:120,119,598...120,126,941
Ensembl chr 2:120,119,444...120,126,996 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Niclosamide affects the reaction [FAS protein mutant form affects the expression of IL6 protein]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Niclosamide inhibits the reaction [resiquimod results in increased expression of IL6 protein]
Niclosamide inhibits the reaction [IL6 protein results in decreased susceptibility to enzalutamide]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of APPA mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of BIRC5 protein]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of IL12A mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of MYC protein]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of SOCS1A mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of TGFB1A mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased phosphorylation of and results in increased activity of STAT3 protein]		 CTD PMID:24561310 PMID:25970160 PMID:26297436 PMID:28318631 PMID:33632240 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgav integrin subunit alpha V multiple interactions ISO Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ITGAV mRNA] CTD PMID:26792726 NCBI chr 3:68,838,524...68,926,653
Ensembl chr 3:68,838,189...68,926,639 		JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions ISO Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ITGB3 mRNA]
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ITGB3 mRNA]		 CTD PMID:26792726 PMID:28824321 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit affects localization
multiple interactions
increases phosphorylation
increases expression		 EXP
ISO		 Niclosamide affects the localization of JUN protein
Acetylcysteine inhibits the reaction [Hydrogen Peroxide promotes the reaction [Niclosamide results in increased phosphorylation of JUN protein]]; Acetylcysteine inhibits the reaction [Niclosamide results in increased phosphorylation of JUN protein]; Hydrogen Peroxide promotes the reaction [Niclosamide results in increased phosphorylation of JUN protein]; JUN protein affects the reaction [Niclosamide results in increased cleavage of PARP1 protein]
Niclosamide results in increased expression of JUN mRNA		 CTD PMID:24750999 PMID:27338550 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kif11 kinesin family member 11 decreases expression ISO Niclosamide results in decreased expression of KIF11 mRNA CTD PMID:28284560 NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766 		JBrowse link
G Kif20a kinesin family member 20A decreases expression ISO Niclosamide results in decreased expression of KIF20A mRNA CTD PMID:28284560 NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780 		JBrowse link
G Kifc1 kinesin family member C1 decreases expression ISO Niclosamide results in decreased expression of KIFC1 mRNA CTD PMID:28284560 NCBI chr20:4,998,832...5,017,107
Ensembl chr20:4,999,047...5,017,105 		JBrowse link
G Lcat lecithin cholesterol acyltransferase increases expression ISO Niclosamide results in increased expression of LCAT mRNA CTD PMID:28284560 NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231 		JBrowse link
G Ldha lactate dehydrogenase A increases expression ISO Niclosamide results in increased expression of LDHA mRNA CTD PMID:22576131 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Lrp5 LDL receptor related protein 5 multiple interactions EXP Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP5 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP5 mRNA]] CTD PMID:32961231 NCBI chr 1:200,814,247...200,917,581
Ensembl chr 1:200,814,250...200,917,581 		JBrowse link
G Lrp6 LDL receptor related protein 6 decreases expression
multiple interactions		 ISO
EXP		 Niclosamide analog results in decreased expression of LRP6 protein; Niclosamide results in decreased expression of LRP6 protein
Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP6 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP6 mRNA]]
Niclosamide results in decreased expression of and results in decreased phosphorylation of LRP6 protein		 CTD PMID:24552774 PMID:24736023 PMID:28284560 PMID:32961231 NCBI chr 4:167,266,581...167,400,155
Ensembl chr 4:167,270,353...167,400,497 		JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 decreases expression ISO Niclosamide results in decreased expression of MAD2L1 mRNA CTD PMID:28284560 NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression ISO Niclosamide results in increased expression of MAP1LC3B protein modified form CTD PMID:30258081 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions		 ISO Niclosamide results in decreased phosphorylation of MAPK1 protein
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK1 protein]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]		 CTD PMID:24561310 PMID:26116531 PMID:28426875 PMID:28824321 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation		 ISO Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK3 protein]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
Niclosamide results in decreased phosphorylation of MAPK3 protein		 CTD PMID:24561310 PMID:26116531 PMID:28426875 PMID:28824321 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK8 protein] CTD PMID:28824321 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK9 protein] CTD PMID:28824321 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO Niclosamide results in decreased expression of MCL1 protein CTD PMID:20215516 PMID:26116531 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mcm2 minichromosome maintenance complex component 2 decreases expression ISO Niclosamide results in decreased expression of MCM2 mRNA; Niclosamide results in decreased expression of MCM2 protein CTD PMID:28284560 PMID:29031202 NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847 		JBrowse link
G Mcm7 minichromosome maintenance complex component 7 decreases expression ISO Niclosamide results in decreased expression of MCM7 protein CTD PMID:29031202 NCBI chr12:17,042,207...17,049,470
Ensembl chr12:17,042,212...17,050,063 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression EXP Niclosamide results in decreased expression of MET mRNA CTD PMID:27338550 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO Niclosamide results in decreased expression of MKI67 mRNA CTD PMID:28284560 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mme membrane metallo-endopeptidase decreases expression ISO Niclosamide results in decreased expression of MME mRNA; Niclosamide results in decreased expression of MME protein CTD PMID:29480568 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO Niclosamide results in decreased expression of MMP2 mRNA; Niclosamide results in decreased expression of MMP2 protein CTD PMID:29251334 PMID:30143678 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp7 matrix metallopeptidase 7 multiple interactions
decreases expression		 EXP
ISO		 Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of MMP7 mRNA]
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of MMP7 mRNA]
Niclosamide results in decreased expression of MMP7 mRNA		 CTD PMID:27338550 PMID:28318631 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions		 ISO Niclosamide results in decreased expression of MMP9 mRNA; Niclosamide results in decreased expression of MMP9 protein
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MMP9 mRNA]		 CTD PMID:28824321 PMID:29480568 PMID:30143678 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mt1-ps3 metallothionein 1, pseudogene 3 increases expression ISO Niclosamide results in increased expression of MT1E mRNA CTD PMID:28284560 NCBI chr17:74,786,652...74,787,040
Ensembl chr17:74,786,654...74,787,135 		JBrowse link
G Mt2A metallothionein 2A increases expression ISO Niclosamide results in increased expression of MT2A mRNA CTD PMID:28284560 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation
multiple interactions
increases expression		 ISO Niclosamide analog results in decreased phosphorylation of MTOR protein; Niclosamide results in decreased phosphorylation of MTOR protein
Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased phosphorylation of MTOR protein]; Niclosamide inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]
Niclosamide results in increased expression of MTOR mRNA		 CTD PMID:19771169 PMID:26643609 PMID:26703449 PMID:28284560 PMID:29843133 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
decreases expression		 EXP
ISO		 Niclosamide inhibits the reaction [GCG protein results in increased expression of MYC mRNA]
Niclosamide results in decreased expression of MYC mRNA; Niclosamide results in decreased expression of MYC protein
[Niclosamide binds to Polyethyleneimine] which results in increased expression of MYC mRNA; [Niclosamide co-treated with bicalutamide] results in decreased expression of MYC mRNA; [Niclosamide co-treated with bicalutamide] results in decreased expression of MYC protein; enzalutamide promotes the reaction [Niclosamide results in decreased expression of MYC protein]; Niclosamide inhibits the reaction [bicalutamide results in increased expression of MYC protein]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of MYC protein]; Niclosamide inhibits the reaction [TNF protein results in increased expression of MYC mRNA]		 CTD PMID:19160421 PMID:20215516 PMID:22576131 PMID:25970160 PMID:25988281 More... NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Ndufa10 NADH:ubiquinone oxidoreductase subunit A10 decreases expression ISO Niclosamide results in decreased expression of NDUFA10 mRNA CTD PMID:22576131 NCBI chr 9:93,007,034...93,041,825
Ensembl chr 9:93,007,042...93,042,560 		JBrowse link
G Ndufa4l2 NDUFA4, mitochondrial complex associated like 2 increases expression ISO Niclosamide results in increased expression of NDUFA4L2 mRNA CTD PMID:22576131 NCBI chr 7:63,351,021...63,359,010
Ensembl chr 7:63,356,883...63,359,010 		JBrowse link
G Ndufa7 NADH:ubiquinone oxidoreductase subunit A7 decreases expression ISO Niclosamide results in decreased expression of NDUFA7 mRNA CTD PMID:22576131 NCBI chr 7:14,609,283...14,622,064
Ensembl chr 7:14,609,146...14,631,976 		JBrowse link
G Ndufa8 NADH:ubiquinone oxidoreductase subunit A8 decreases expression ISO Niclosamide results in decreased expression of NDUFA8 mRNA CTD PMID:22576131 NCBI chr 3:19,386,063...19,402,093
Ensembl chr 3:19,386,065...19,402,071 		JBrowse link
G Ndufb10 NADH:ubiquinone oxidoreductase subunit B10 decreases expression ISO Niclosamide results in decreased expression of NDUFB10 mRNA CTD PMID:22576131 NCBI chr10:13,749,273...13,751,434
Ensembl chr10:13,749,275...13,751,442 		JBrowse link
G Ndufb6 NADH:ubiquinone oxidoreductase subunit B6 decreases expression ISO Niclosamide results in decreased expression of NDUFB6 mRNA CTD PMID:22576131 NCBI chr 5:55,400,543...55,410,110
Ensembl chr 5:55,400,543...55,410,181 		JBrowse link
G Ndufc1 NADH:ubiquinone oxidoreductase subunit C1 increases expression ISO Niclosamide results in increased expression of NDUFC1 mRNA CTD PMID:22576131 NCBI chr 2:135,447,067...135,450,950
Ensembl chr 2:135,447,119...135,450,874 		JBrowse link
G Ndufs2 NADH:ubiquinone oxidoreductase core subunit S2 decreases expression ISO Niclosamide results in decreased expression of NDUFS2 mRNA CTD PMID:22576131 NCBI chr13:83,654,402...83,671,474
Ensembl chr13:83,654,406...83,671,420 		JBrowse link
G Ndufs3 NADH:ubiquinone oxidoreductase core subunit S3 decreases expression ISO Niclosamide results in decreased expression of NDUFS3 mRNA CTD PMID:22576131 NCBI chr 3:76,876,646...76,883,824
Ensembl chr 3:76,876,646...76,883,824 		JBrowse link
G Ndufs7 NADH:ubiquinone oxidoreductase core subunit S7 decreases expression ISO Niclosamide results in decreased expression of NDUFS7 mRNA CTD PMID:22576131 NCBI chr 7:9,452,556...9,460,135
Ensembl chr 7:9,450,392...9,460,195 		JBrowse link
G Ndufs8 NADH:ubiquinone oxidoreductase core subunit S8 decreases expression ISO Niclosamide results in decreased expression of NDUFS8 mRNA CTD PMID:22576131 NCBI chr 1:201,140,585...201,144,573
Ensembl chr 1:201,140,585...201,144,511 		JBrowse link
G Ndufv3 NADH:ubiquinone oxidoreductase subunit V3 increases expression ISO Niclosamide results in increased expression of NDUFV3 mRNA CTD PMID:22576131 NCBI chr20:9,612,462...9,621,622
Ensembl chr20:9,612,431...9,623,074 		JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of and affects the localization of NFATC1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFATC1 mRNA]		 CTD PMID:26792726 PMID:28824321 NCBI chr18:74,046,421...74,156,041
Ensembl chr18:74,046,904...74,156,028 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 affects localization ISO Niclosamide affects the localization of NFKB1 protein CTD PMID:26116531 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha decreases phosphorylation
multiple interactions		 ISO Niclosamide results in decreased phosphorylation of NFKBIA protein
Niclosamide inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Niclosamide inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Niclosamide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein]]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of NFKBIA protein]; Niclosamide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein]		 CTD PMID:20215516 PMID:26116531 PMID:27492973 PMID:28824321 PMID:33524445 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nkd1 NKD inhibitor of WNT signaling pathway 1 multiple interactions
increases expression		 ISO Niclosamide inhibits the reaction [Lithium Chloride results in increased expression of NKD1 mRNA]
Niclosamide results in increased expression of NKD1 mRNA		 CTD PMID:22576131 PMID:24534281 NCBI chr19:18,476,344...18,549,380
Ensembl chr19:18,476,344...18,549,380 		JBrowse link
G Nkx3-1 NK3 homeobox 1 multiple interactions
decreases expression		 ISO [Niclosamide co-treated with bicalutamide] results in decreased expression of NKX3-1 mRNA
Niclosamide results in decreased expression of NKX3-1 mRNA		 CTD PMID:28500234 NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NLRP3 protein] CTD PMID:33524445 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Notch1 notch receptor 1 decreases activity
multiple interactions		 ISO
EXP		 Niclosamide results in decreased activity of NOTCH1 protein
Niclosamide inhibits the reaction [Thioacetamide results in increased expression of NOTCH1 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of NOTCH1 mRNA]]		 CTD PMID:19160421 PMID:32961231 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO Niclosamide binds to and results in increased activity of NR1I3 protein alternative form CTD PMID:31312845 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Ocstamp osteoclast stimulatory transmembrane protein multiple interactions ISO Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OCSTAMP mRNA] CTD PMID:28824321 NCBI chr 3:154,131,113...154,141,611
Ensembl chr 3:154,132,328...154,136,991 		JBrowse link
G Orc1 origin recognition complex, subunit 1 decreases expression ISO Niclosamide results in decreased expression of ORC1 mRNA CTD PMID:28284560 NCBI chr 5:123,324,273...123,348,375
Ensembl chr 5:123,324,315...123,348,375 		JBrowse link
G Oscar osteoclast associated Ig-like receptor multiple interactions ISO Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OSCAR mRNA]
Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of OSCAR mRNA]		 CTD PMID:26792726 PMID:28824321 NCBI chr 1:65,607,214...65,615,395
Ensembl chr 1:65,607,410...65,613,758 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
decreases expression
increases expression
increases cleavage		 ISO [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased cleavage of PARP1 protein
Niclosamide results in decreased expression of PARP1 protein
Niclosamide results in increased expression of PARP1 protein modified form
Niclosamide results in increased cleavage of PARP1 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Niclosamide results in increased cleavage of PARP1 protein]; bicalutamide promotes the reaction [Niclosamide results in increased expression of PARP1 protein modified form]; Hydrogen Peroxide promotes the reaction [Niclosamide results in increased cleavage of PARP1 protein]; JUN protein affects the reaction [Niclosamide results in increased cleavage of PARP1 protein]; TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of PARP1 protein]; WNT7A protein affects the reaction [Niclosamide results in increased cleavage of PARP1 protein]		 CTD PMID:24750999 PMID:25174399 PMID:26917416 PMID:28500234 PMID:30258081 More... NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pc pyruvate carboxylase increases expression ISO Niclosamide results in increased expression of PC mRNA CTD PMID:22576131 NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380 		JBrowse link
G Pfkm phosphofructokinase, muscle decreases expression ISO Niclosamide results in decreased expression of PFKM mRNA CTD PMID:22576131 NCBI chr 7:129,221,679...129,259,192
Ensembl chr 7:129,221,653...129,259,192 		JBrowse link
G Phlda1 pleckstrin homology-like domain, family A, member 1 increases expression ISO Niclosamide results in increased expression of PHLDA1 mRNA CTD PMID:28284560 NCBI chr 7:46,967,433...46,969,637
Ensembl chr 7:46,967,409...46,969,861 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha increases expression
multiple interactions		 ISO Niclosamide results in increased expression of PIK3CA mRNA
Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CCNG2 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CSGALNACT1 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CXCL8 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of HBP1 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of HEY1 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of CCNE2 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of DSCC1 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of ENDOD1 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of PPP2R1B mRNA]		 CTD PMID:27542212 PMID:29843133 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pkm pyruvate kinase M1/2 increases expression ISO Niclosamide results in increased expression of PKM mRNA CTD PMID:22576131 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases phosphorylation ISO Niclosamide results in decreased phosphorylation of POU5F1 protein CTD PMID:23333246 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases expression ISO Niclosamide results in increased expression of PPARD mRNA CTD PMID:22576131 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968 		JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta decreases expression ISO Niclosamide results in decreased expression of PPP2CB mRNA CTD PMID:22576131 NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576 		JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha increases expression ISO Niclosamide results in increased expression of PPP2R1A mRNA CTD PMID:22576131 NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129 		JBrowse link
G Ppp2r1b protein phosphatase 2 scaffold subunit A beta multiple interactions ISO Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of PPP2R1B mRNA] CTD PMID:27542212 NCBI chr 8:51,195,860...51,228,442
Ensembl chr 8:51,186,717...51,228,485 		JBrowse link
G Ppp2r2b protein phosphatase 2, regulatory subunit B, beta decreases expression ISO Niclosamide results in decreased expression of PPP2R2B mRNA CTD PMID:22576131 NCBI chr18:34,653,716...35,080,889
Ensembl chr18:34,653,721...35,081,025 		JBrowse link
G Ppp2r2c protein phosphatase 2, regulatory subunit B, gamma decreases expression ISO Niclosamide results in decreased expression of PPP2R2C mRNA CTD PMID:22576131 NCBI chr14:73,846,547...73,931,178
Ensembl chr14:73,846,547...73,931,864 		JBrowse link
G Prdm1 PR/SET domain 1 multiple interactions ISO Niclosamide affects the reaction [FAS protein mutant form affects the expression of PRDM1 mRNA] CTD PMID:33632240 NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488 		JBrowse link
G Prkcq protein kinase C, theta increases expression ISO Niclosamide results in increased expression of PRKCQ mRNA CTD PMID:22576131 NCBI chr17:67,246,394...67,379,049
Ensembl chr17:67,246,394...67,378,704 		JBrowse link
G Pten phosphatase and tensin homolog increases expression ISO Niclosamide results in increased expression of PTEN mRNA CTD PMID:29843133 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Rad54l RAD54 like increases expression ISO Niclosamide results in increased expression of RAD54L mRNA CTD PMID:28284560 NCBI chr 5:129,575,431...129,605,100
Ensembl chr 5:129,575,378...129,605,070 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases phosphorylation
decreases expression		 ISO Niclosamide analog results in decreased phosphorylation of RAF1 protein
Niclosamide analog results in decreased expression of RAF1 protein; Niclosamide results in decreased expression of RAF1 protein		 CTD PMID:28284560 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression		 ISO
EXP		 Niclosamide affects the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of RELA protein]; Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of and results in increased phosphorylation of RELA protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of RELA protein]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of RELA protein modified form]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of RELA protein modified form]
Imatinib Mesylate promotes the reaction [Niclosamide results in decreased expression of RELA protein]; Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased phosphorylation of RELA protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of RELA protein]; Niclosamide inhibits the reaction [TNF protein results in increased activity of RELA protein]; Niclosamide inhibits the reaction [WNT3A protein affects the localization of RELA protein]; Niclosamide promotes the reaction [Imatinib Mesylate results in decreased expression of RELA protein]; Niclosamide results in decreased phosphorylation of and affects the localization of RELA protein		 CTD PMID:20215516 PMID:26116531 PMID:26643609 PMID:27492973 PMID:28318631 More... NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rhof ras homolog family member F, filopodia associated multiple interactions ISO Niclosamide inhibits the reaction [Adenosine Triphosphate results in increased expression of RHOF mRNA] CTD PMID:29733962 NCBI chr12:33,422,375...33,446,689
Ensembl chr12:33,431,280...33,446,703 		JBrowse link
G Ripor3 RIPOR family member 3 increases expression ISO Niclosamide results in increased expression of FAM65C mRNA CTD PMID:28284560 NCBI chr 3:156,687,253...156,760,524
Ensembl chr 3:156,687,517...156,715,061 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 decreases expression ISO Niclosamide results in decreased expression of ROCK1 mRNA; Niclosamide results in decreased expression of ROCK1 protein CTD PMID:29251334 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571 		JBrowse link
G Rps6 ribosomal protein S6 affects phosphorylation ISO Niclosamide affects the phosphorylation of RPS6 protein CTD PMID:27542212 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO Niclosamide results in decreased phosphorylation of RPS6KB1 protein CTD PMID:27542212 PMID:30258081 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases expression ISO Niclosamide results in decreased expression of RRM2 mRNA CTD PMID:28284560 NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773 		JBrowse link
G Runx2 RUNX family transcription factor 2 decreases expression ISO Niclosamide results in decreased expression of RUNX2 mRNA CTD PMID:28824321 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G S100a4 S100 calcium-binding protein A4 decreases expression
multiple interactions		 ISO Niclosamide results in decreased expression of S100A4 mRNA; Niclosamide results in decreased expression of S100A4 protein
Niclosamide inhibits the reaction [Adenosine Triphosphate results in increased expression of S100A4 protein]		 CTD PMID:21685359 PMID:29733962 NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO Niclosamide inhibits the reaction [Doxorubicin results in increased expression of SERPINE1 mRNA] CTD PMID:28318631 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Serpine2 serpin family E member 2 multiple interactions EXP Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of SERPINE2 mRNA] CTD PMID:28318631 NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 decreases expression ISO Niclosamide results in decreased expression of SLC2A1 mRNA CTD PMID:22576131 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Niclosamide results in decreased expression of SLC2A3 mRNA CTD PMID:22576131 NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO
EXP		 HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]; Niclosamide inhibits the reaction [TGFB1 protein promotes the reaction [SMAD3 protein binds to HIPK2 promoter]]; Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
Niclosamide inhibits the reaction [Doxorubicin results in increased phosphorylation of SMAD3 protein]		 CTD PMID:28318631 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions
decreases expression		 ISO
EXP		 Niclosamide inhibits the reaction [Doxorubicin results in increased expression of SNAI1 mRNA]
Niclosamide results in decreased expression of SNAI1 mRNA; Niclosamide results in decreased expression of SNAI1 protein
Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of SNAI1 protein]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]		 CTD PMID:26643609 PMID:28318631 PMID:30143678 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Snai2 snail family transcriptional repressor 2 multiple interactions
decreases expression		 ISO WNT7A protein affects the reaction [Niclosamide results in increased expression of SNAI2 protein]
Niclosamide results in decreased expression of SNAI2 protein		 CTD PMID:25174399 NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased phosphorylation of SRC protein] CTD PMID:26643609 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation
multiple interactions
decreases expression		 ISO Niclosamide analog results in decreased phosphorylation of STAT3 protein; Niclosamide results in decreased phosphorylation of STAT3 protein
Niclosamide affects the reaction [FAS protein mutant form affects the phosphorylation of STAT3 protein]
[Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased phosphorylation of STAT3 protein]] which results in increased susceptibility to Erlotinib Hydrochloride; enzalutamide promotes the reaction [Niclosamide results in decreased phosphorylation of and results in decreased activity of STAT3 protein]; Niclosamide inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein]; Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased phosphorylation of STAT3 protein]; Niclosamide inhibits the reaction [IL6 protein results in increased phosphorylation of and results in increased activity of STAT3 protein]; Niclosamide inhibits the reaction [STAT3 protein results in decreased susceptibility to enzalutamide]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased phosphorylation of STAT3 protein]; Niclosamide results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of STAT3 protein; Niclosamide results in decreased expression of and results in decreased phosphorylation of STAT3 protein
Niclosamide analog results in decreased expression of STAT3 protein; Niclosamide results in decreased expression of STAT3 protein		 CTD PMID:23333246 PMID:23894143 PMID:24552774 PMID:25970160 PMID:26116531 More... NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tacc3 transforming, acidic coiled-coil containing protein 3 decreases expression ISO Niclosamide results in decreased expression of TACC3 mRNA CTD PMID:28284560 NCBI chr14:77,051,209...77,065,343
Ensembl chr14:77,051,215...77,065,219 		JBrowse link
G Tcf7 transcription factor 7 multiple interactions ISO Niclosamide affects the reaction [FAS protein mutant form affects the expression of TCF7 protein] CTD PMID:33632240 NCBI chr10:36,423,443...36,454,350
Ensembl chr10:36,423,445...36,453,535 		JBrowse link
G Tcim transcriptional and immune response regulator increases expression ISO Niclosamide results in increased expression of TCIM mRNA CTD PMID:28284560 NCBI chr16:67,595,762...67,597,055
Ensembl chr16:67,593,410...67,597,581 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO
EXP		 HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]]; HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]]; HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]; Niclosamide inhibits the reaction [TGFB1 protein promotes the reaction [SMAD3 protein binds to HIPK2 promoter]]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 protein]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of CCL2 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of CCL20 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FAS mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HES1 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HEY1 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HEY2 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 protein]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of ICAM1 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of MMP7 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of RELA protein modified form]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of SERPINE2 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]		 CTD PMID:28318631 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO Niclosamide results in increased expression of TIMP2 mRNA CTD PMID:30143678 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
G Tk1 thymidine kinase 1 decreases expression ISO Niclosamide results in decreased expression of TK1 mRNA CTD PMID:28284560 NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases activity		 ISO Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TNF mRNA]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Niclosamide inhibits the reaction [TNF protein affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of FOXM1 protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of RELA protein]; Niclosamide inhibits the reaction [TNF protein results in increased activity of AKT1 protein]; Niclosamide inhibits the reaction [TNF protein results in increased activity of RELA protein]; Niclosamide inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Niclosamide inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; Niclosamide inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA]; Niclosamide inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [TNF protein results in increased expression of MYC mRNA]; Niclosamide inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
Niclosamide results in decreased activity of TNF protein		 CTD PMID:20215516 PMID:24561310 PMID:27492973 PMID:28318631 PMID:33524445 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ATP6V0D2 mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ITGAV mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ITGB3 mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of OSCAR mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased phosphorylation of AKT1 protein]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased phosphorylation of STAT3 protein]
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ACP5 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of and affects the localization of NFATC1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 protein modified form]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of FOS mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ITGB3 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MMP9 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFATC1 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OCSTAMP mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OSCAR mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of TRAF6 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK3 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK8 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK9 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of NFKBIA protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of RELA protein]		 CTD PMID:26792726 PMID:28824321 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
decreases response to substance
increases response to substance		 ISO [Niclosamide binds to Polyethyleneimine] which results in increased expression of TP53 mRNA; TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX12B mRNA]; TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX5 mRNA]; TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of BBC3 mRNA]; TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of CDKN1A mRNA]; TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of CASP3 protein]; TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of CASP9 protein]; TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of PARP1 protein]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX12B mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX5 mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of CDKN1A mRNA]
[TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of adrenic acid; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of Arachidonic Acid; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of Docosahexaenoic Acids; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of Eicosapentaenoic Acid; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of Lysophosphatidylcholines; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of lysophosphatidylethanolamine; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased cleavage of PARP1 protein; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased expression of CASP3 protein modified form
Niclosamide results in increased expression of TP53 mRNA; Niclosamide results in increased expression of TP53 protein
TP53 protein results in decreased susceptibility to Niclosamide
TP53 gene mutant form results in increased susceptibility to Niclosamide; TP53 protein mutant form results in increased susceptibility to Niclosamide
Niclosamide results in increased expression of TRP53 protein		 CTD PMID:22576131 PMID:25988281 PMID:29031202 PMID:30258081 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tpi1 triosephosphate isomerase 1 increases expression ISO Niclosamide results in increased expression of TPI1 mRNA CTD PMID:22576131 NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541 		JBrowse link
G Tpx2 TPX2, microtubule nucleation factor decreases expression ISO Niclosamide results in decreased expression of TPX2 mRNA CTD PMID:28284560 NCBI chr 3:141,318,428...141,360,684
Ensembl chr 3:141,318,455...141,360,468 		JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of TRAF6 protein] CTD PMID:28824321 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Trip13 thyroid hormone receptor interactor 13 decreases expression ISO Niclosamide results in decreased expression of TRIP13 mRNA CTD PMID:28284560 NCBI chr 1:29,357,093...29,402,078
Ensembl chr 1:29,357,130...29,402,074 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 decreases expression ISO Niclosamide results in decreased expression of TWIST1 protein CTD PMID:29480568 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653 		JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C multiple interactions
decreases expression		 ISO [Niclosamide co-treated with bicalutamide] results in decreased expression of UBE2C mRNA
Niclosamide results in decreased expression of UBE2C mRNA		 CTD PMID:28500234 NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339 		JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 decreases expression ISO Niclosamide results in decreased expression of UHRF1 mRNA CTD PMID:28284560 NCBI chr 9:1,133,117...1,154,639
Ensembl chr 9:1,134,909...1,154,631 		JBrowse link
G Utp3 UTP3, small subunit processome component decreases expression ISO Niclosamide results in decreased expression of UTP3 mRNA CTD PMID:27226553 NCBI chr14:19,515,716...19,517,370
Ensembl chr14:19,515,669...19,517,396 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Niclosamide results in decreased expression of VEGFA mRNA; Niclosamide results in decreased expression of VEGFA protein CTD PMID:29251334 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vim vimentin multiple interactions
decreases expression		 ISO HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]]; Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of VIM protein]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]
Niclosamide results in decreased expression of VIM mRNA; Niclosamide results in decreased expression of VIM protein		 CTD PMID:26643609 PMID:28318631 PMID:30143678 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Vpreb1a V-set pre-B cell surrogate light chain 1A decreases expression ISO Niclosamide results in decreased expression of VPREB1 mRNA CTD PMID:27226553 NCBI chr11:84,126,969...84,127,846
Ensembl chr11:84,126,969...84,127,846 		JBrowse link
G Wnt2b Wnt family member 2B decreases expression ISO Niclosamide results in decreased expression of WNT2B mRNA CTD PMID:22576131 NCBI chr 2:192,454,226...192,468,599
Ensembl chr 2:192,453,824...192,470,308 		JBrowse link
G Wnt3 Wnt family member 3 decreases expression ISO Niclosamide results in decreased expression of WNT3 mRNA CTD PMID:22576131 NCBI chr10:88,680,248...88,724,170
Ensembl chr10:88,680,248...88,724,099 		JBrowse link
G Wnt3a Wnt family member 3A multiple interactions
decreases expression		 ISO
EXP		 Niclosamide inhibits the reaction [WNT3A protein affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [WNT3A protein affects the localization of RELA protein]; Niclosamide inhibits the reaction [WNT3A protein results in increased stability of CTNNB1 protein]
Niclosamide inhibits the reaction [Thioacetamide results in increased expression of WNT3A mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of WNT3A mRNA]]
Niclosamide results in decreased expression of WNT3A mRNA		 CTD PMID:19772353 PMID:22576131 PMID:27492973 PMID:32961231 NCBI chr10:44,034,174...44,078,463
Ensembl chr10:44,034,194...44,078,324 		JBrowse link
G Wnt7a Wnt family member 7A increases response to substance
multiple interactions
decreases activity		 ISO WNT7A protein results in increased susceptibility to Niclosamide
WNT7A protein affects the reaction [Niclosamide results in increased cleavage of CASP3 protein]; WNT7A protein affects the reaction [Niclosamide results in increased cleavage of PARP1 protein]; WNT7A protein affects the reaction [Niclosamide results in increased expression of CDH1 protein]; WNT7A protein affects the reaction [Niclosamide results in increased expression of SNAI2 protein]
Niclosamide results in decreased activity of WNT7A protein		 CTD PMID:25174399 NCBI chr 4:123,863,108...123,908,981
Ensembl chr 4:123,863,108...123,908,981 		JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO Niclosamide results in decreased expression of XIAP protein CTD PMID:20215516 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
G Zfp36 zinc finger protein 36 increases expression ISO Niclosamide results in increased expression of ZFP36 mRNA CTD PMID:28284560 NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564 		JBrowse link
G Zic2 Zic family member 2 increases expression ISO Niclosamide results in increased expression of ZIC2 mRNA CTD PMID:28284560 NCBI chr15:99,576,697...99,581,522
Ensembl chr15:99,576,697...99,581,522 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19765
    role 19738
      chemical role 19377
        donor 18770
          Bronsted acid 18675
            oxoacid 18641
              carbon oxoacid 18526
                carboxylic acid 18523
                  chlorocarboxylic acid 433
                    (S)-2-chloropropanoic acid 0
                    2,4-dichloro-3-oxoadipic acid 0
                    2-chloroacrylic acid 0
                    2-chlorosuccinic acid 0
                    3-chloroacrylic acid + 0
                    4,4'-dichlorobenzilic acid + 4
                    5-chloromuconolactone 0
                    chloroacetic acid + 29
                    chlorobenzoic acid + 415
                    chloromuconic acid + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19765
    subatomic particle 19763
      composite particle 19763
        hadron 19763
          baryon 19763
            nucleon 19763
              atomic nucleus 19763
                atom 19763
                  main group element atom 19712
                    p-block element atom 19712
                      carbon group element atom 19658
                        carbon atom 19654
                          organic molecular entity 19654
                            organic group 18856
                              organic divalent group 18842
                                organodiyl group 18842
                                  carbonyl group 18807
                                    carbonyl compound 18807
                                      carboxylic acid 18523
                                        chlorocarboxylic acid 433
                                          (S)-2-chloropropanoic acid 0
                                          2,4-dichloro-3-oxoadipic acid 0
                                          2-chloroacrylic acid 0
                                          2-chlorosuccinic acid 0
                                          3-chloroacrylic acid + 0
                                          4,4'-dichlorobenzilic acid + 4
                                          5-chloromuconolactone 0
                                          chloroacetic acid + 29
                                          chlorobenzoic acid + 415
                                          chloromuconic acid + 0
paths to the root