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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chlorocarboxylic acid
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Accession:CHEBI:36685 term browser browse the term
Definition:A carboxylic acid containing at least one chloro group.
Synonyms:related_synonym: chlorocarboxylic acids


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chloroacetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of ATF4 protein] CTD PMID:25451595 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions
increases cleavage
ISO Acetylcysteine inhibits the reaction [chloroacetic acid results in increased cleavage of ATF6 protein] CTD PMID:25451595 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO SB 203580 inhibits the reaction [chloroacetic acid results in increased expression of BAX mRNA] CTD PMID:23103613 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO chloroacetic acid results in decreased expression of BCL2 mRNA
SB 203580 inhibits the reaction [chloroacetic acid results in decreased expression of BCL2 mRNA]
CTD PMID:23103613 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Capn1 calpain 1 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of CAPN1 protein] CTD PMID:25451595 NCBI chr 1:221,346,081...221,370,965
Ensembl chr 1:221,346,066...221,370,322
JBrowse link
G Capn2 calpain 2 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of CAPN2 protein] CTD PMID:25451595 NCBI chr13:100,878,649...100,928,811
Ensembl chr13:100,878,650...100,928,811
JBrowse link
G Casp12 caspase 12 multiple interactions ISO Acetylcysteine inhibits the reaction [chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein]; chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein; HSP90B1 protein promotes the reaction [chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein]; HSPA5 protein promotes the reaction [chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein] CTD PMID:25451595 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO chloroacetic acid results in increased cleavage of and results in increased activity of CASP3 protein; HSP90B1 protein promotes the reaction [chloroacetic acid results in increased cleavage of CASP3 protein]; HSPA5 protein promotes the reaction [chloroacetic acid results in increased cleavage of CASP3 protein]; SB 203580 inhibits the reaction [chloroacetic acid results in increased activity of CASP3 protein] CTD PMID:23103613 PMID:25451595 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions ISO chloroacetic acid results in increased cleavage of and results in increased activity of CASP7 protein; SB 203580 inhibits the reaction [chloroacetic acid results in increased activity of CASP7 protein] CTD PMID:23103613 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp9 caspase 9 increases cleavage ISO chloroacetic acid results in increased cleavage of CASP9 protein CTD PMID:23103613 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of DDIT3 protein]
chloroacetic acid results in increased expression of DDIT3 mRNA; chloroacetic acid results in increased expression of DDIT3 protein
CTD PMID:25451595 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation
multiple interactions
ISO chloroacetic acid results in increased phosphorylation of EIF2A protein
Acetylcysteine inhibits the reaction [chloroacetic acid results in increased phosphorylation of EIF2A protein]
CTD PMID:25451595 NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases phosphorylation
ISO Acetylcysteine inhibits the reaction [chloroacetic acid results in increased phosphorylation of EIF2AK3 protein] CTD PMID:25451595 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions
increases phosphorylation
ISO Acetylcysteine inhibits the reaction [chloroacetic acid results in increased phosphorylation of ERN1 protein] CTD PMID:25451595 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO chloroacetic acid results in decreased expression of G6PC mRNA; chloroacetic acid results in decreased expression of G6PC protein CTD PMID:28189721 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase decreases activity EXP chloroacetic acid results in decreased activity of GAPDH protein CTD PMID:15720133 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Gk glycerol kinase decreases expression
multiple interactions
ISO chloroacetic acid results in decreased expression of GK mRNA
[ethylene dichloride metabolite results in increased abundance of chloroacetic acid] which results in decreased expression of GK mRNA
CTD PMID:28960355 NCBI chr  X:54,227,291...54,303,897
Ensembl chr  X:54,227,397...54,303,864
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP [vinylidene chloride co-treated with chloroacetic acid] results in increased expression of HMOX1 protein CTD PMID:9860887 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of HSP90B1 protein]; HSP90B1 protein promotes the reaction [chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein]; HSP90B1 protein promotes the reaction [chloroacetic acid results in increased cleavage of CASP3 protein]
chloroacetic acid results in increased expression of HSP90B1 mRNA; chloroacetic acid results in increased expression of HSP90B1 protein
CTD PMID:25451595 NCBI chr 7:27,226,570...27,240,533
Ensembl chr 7:27,226,569...27,240,533
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of HSPA5 protein]; HSPA5 protein promotes the reaction [chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein]; HSPA5 protein promotes the reaction [chloroacetic acid results in increased cleavage of CASP3 protein]
chloroacetic acid results in increased expression of HSPA5 mRNA; chloroacetic acid results in increased expression of HSPA5 protein
CTD PMID:25451595 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions EXP [vinylidene chloride co-treated with chloroacetic acid] results in increased expression of HSPD1 protein CTD PMID:9860887 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression ISO chloroacetic acid results in decreased expression of IGF1 mRNA; chloroacetic acid results in decreased expression of IGF1 protein CTD PMID:31520740 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Mbp myelin basic protein affects expression EXP chloroacetic acid affects the expression of MBP mRNA CTD PMID:22954530 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO chloroacetic acid results in decreased expression of MCL1 mRNA CTD PMID:23103613 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mir451a microRNA 451a multiple interactions
increases expression
ISO [ethylene dichloride metabolite results in increased abundance of chloroacetic acid] which results in increased expression of MIR451A mRNA
chloroacetic acid results in increased expression of MIR451A mRNA
CTD PMID:28960355 NCBI chr10:65,291,204...65,291,275
Ensembl chr10:65,291,204...65,291,275
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO chloroacetic acid results in increased cleavage of PARP1 protein CTD PMID:23103613 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pygl glycogen phosphorylase L decreases expression ISO chloroacetic acid results in decreased expression of PYGL mRNA; chloroacetic acid results in decreased expression of PYGL protein CTD PMID:28189721 NCBI chr 6:92,597,759...92,643,734
Ensembl chr 6:92,597,706...92,643,847
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of XBP1 protein alternative form]
chloroacetic acid results in increased expression of XBP1 mRNA alternative form; chloroacetic acid results in increased expression of XBP1 protein alternative form
CTD PMID:25451595 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
chloropropylate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Dihydrotestosterone inhibits the reaction [chloropropylate results in increased activity of AR protein] CTD PMID:15064155 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO chloropropylate results in increased activity of ESR1 protein CTD PMID:15064155 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 increases activity ISO chloropropylate results in increased activity of ESR2 protein CTD PMID:15064155 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO chloropropylate binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
furosemide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO
EXP
Furosemide promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]
[Furosemide results in increased activity of ABCC2 protein] promotes the reaction [Glucose results in increased secretion of S-(2,4-dinitrophenyl)glutathione]
CTD PMID:12704183 PMID:19782883 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO Furosemide inhibits the reaction [ABCC3 protein affects the transport of estradiol-17 beta-glucuronide] CTD PMID:12704183 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases export
increases transport
ISO ABCC4 protein results in increased export of Furosemide
ABCC4 protein results in increased transport of Furosemide
CTD PMID:17135398 PMID:17939016 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 affects expression EXP Furosemide affects the expression of ADAMTS1 mRNA CTD PMID:16526316 NCBI chr11:25,342,119...25,350,938
Ensembl chr11:25,342,126...25,350,974
JBrowse link
G Agt angiotensinogen increases expression ISO Furosemide results in increased expression of AGT protein modified form CTD PMID:18081357 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects phosphorylation EXP Furosemide affects the phosphorylation of AKT1 protein CTD PMID:17497460 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin multiple interactions
affects binding
ISO [bucolome inhibits the reaction [Furosemide binds to ALB protein]] which affects the abundance of Furosemide; bucolome inhibits the reaction [Furosemide binds to ALB protein] CTD PMID:15640375 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP Furosemide results in increased expression of ALDH1A1 mRNA CTD PMID:28138970 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Ang angiogenin affects expression EXP Furosemide affects the expression of ANG mRNA CTD PMID:16526316 NCBI chr15:28,022,926...28,028,636 JBrowse link
G Angpt2 angiopoietin 2 affects expression EXP Furosemide affects the expression of ANGPT2 mRNA CTD PMID:16526316 NCBI chr16:75,966,480...76,016,147
Ensembl chr16:75,966,352...76,016,195
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 affects expression EXP Furosemide affects the expression of APAF1 mRNA CTD PMID:17497460 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Aqp2 aquaporin 2 increases expression EXP Furosemide results in increased expression of AQP2 mRNA; Furosemide results in increased expression of AQP2 protein CTD PMID:17584643 NCBI chr 7:141,237,802...141,242,837
Ensembl chr 7:141,237,768...141,245,165
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein affects expression EXP Furosemide affects the expression of ARC mRNA CTD PMID:17497460 NCBI chr 7:115,907,097...115,911,059
Ensembl chr 7:115,907,097...115,910,541
JBrowse link
G Arntl aryl hydrocarbon receptor nuclear translocator-like decreases secretion ISO ARNTL gene mutant form results in decreased secretion of Furosemide CTD PMID:27056296 NCBI chr 1:178,039,002...178,137,469
Ensembl chr 1:178,039,063...178,137,465
JBrowse link
G Atm ATM serine/threonine kinase affects expression EXP Furosemide affects the expression of ATM mRNA CTD PMID:17497460 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Atp6v1b1 ATPase H+ transporting V1 subunit B1 multiple interactions
increases expression
EXP [Furosemide co-treated with Amiloride] results in increased expression of ATP6V1B1 protein
Furosemide results in increased expression of ATP6V1B1 protein
CTD PMID:17311909 NCBI chr 4:115,417,100...115,435,754
Ensembl chr 4:115,416,580...115,437,206
JBrowse link
G Avpr2 arginine vasopressin receptor 2 increases expression EXP Furosemide results in increased expression of AVPR2 mRNA CTD PMID:17584643 NCBI chr  X:156,889,006...156,892,707
Ensembl chr  X:156,889,410...156,891,213
JBrowse link
G Bad BCL2-associated agonist of cell death affects expression EXP Furosemide affects the expression of BAD mRNA CTD PMID:17497460 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bak1 BCL2-antagonist/killer 1 affects expression EXP Furosemide affects the expression of BAK1 mRNA CTD PMID:17497460 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects expression EXP Furosemide affects the expression of BAX mRNA CTD PMID:17497460 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl10 BCL10, immune signaling adaptor affects expression EXP Furosemide affects the expression of BCL10 mRNA CTD PMID:17497460 NCBI chr 2:251,805,392...251,814,957
Ensembl chr 2:251,805,392...251,814,957
JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression EXP Furosemide affects the expression of BCL2 mRNA CTD PMID:17497460 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l10 BCL2 like 10 affects expression EXP Furosemide affects the expression of BCL2L10 mRNA CTD PMID:17497460 NCBI chr 8:82,288,705...82,294,750
Ensembl chr 8:82,288,705...82,294,744
JBrowse link
G Bcl2l11 BCL2 like 11 affects expression EXP Furosemide affects the expression of BCL2L11 mRNA CTD PMID:17497460 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Bcl2l2 Bcl2-like 2 affects expression EXP Furosemide affects the expression of BCL2L2 mRNA CTD PMID:17497460 NCBI chr15:33,543,774...33,549,165
Ensembl chr15:33,544,312...33,549,164
JBrowse link
G Bid BH3 interacting domain death agonist affects expression EXP Furosemide affects the expression of BID mRNA CTD PMID:17497460 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Bik BCL2-interacting killer affects expression EXP Furosemide affects the expression of BIK mRNA CTD PMID:17497460 NCBI chr 7:124,390,924...124,410,449
Ensembl chr 7:124,391,432...124,410,447
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 affects expression EXP Furosemide affects the expression of BIRC2 mRNA CTD PMID:17497460 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 affects expression EXP Furosemide affects the expression of BIRC5 mRNA CTD PMID:17497460 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Birc6 baculoviral IAP repeat-containing 6 affects expression EXP Furosemide affects the expression of BIRC6 mRNA CTD PMID:17497460 NCBI chr 6:21,900,763...22,092,484
Ensembl chr 6:21,950,100...22,092,346
JBrowse link
G Bok BCL2 family apoptosis regulator BOK affects expression EXP Furosemide affects the expression of BOK mRNA CTD PMID:17497460 NCBI chr 9:100,829,593...100,840,498
Ensembl chr 9:100,829,552...100,840,504
JBrowse link
G Bsnd barttin CLCNK type accessory subunit beta decreases expression EXP Furosemide results in decreased expression of BSND mRNA CTD PMID:12759757 NCBI chr 5:126,071,849...126,080,647
Ensembl chr 5:126,071,846...126,080,698
JBrowse link
G Calb1 calbindin 1 increases expression ISO Furosemide results in increased expression of CALB1 mRNA; Furosemide results in increased expression of CALB1 protein CTD PMID:17652376 NCBI chr 5:29,538,380...29,562,774
Ensembl chr 5:29,538,380...29,562,773
JBrowse link
G Car2 carbonic anhydrase 2 decreases activity
increases expression
ISO
EXP
Furosemide results in decreased activity of CA2 protein
Furosemide results in increased expression of CA2 mRNA
CTD PMID:16858005 PMID:28138970 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Casp1 caspase 1 affects expression EXP Furosemide affects the expression of CASP1 mRNA CTD PMID:17497460 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp12 caspase 12 affects expression EXP Furosemide affects the expression of CASP12 mRNA CTD PMID:17497460 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp14 caspase 14 affects expression EXP Furosemide affects the expression of CASP14 mRNA CTD PMID:17497460 NCBI chr 7:13,938,376...13,944,286
Ensembl chr 7:13,938,302...13,945,130
JBrowse link
G Casp2 caspase 2 affects expression EXP Furosemide affects the expression of CASP2 mRNA CTD PMID:17497460 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Casp3 caspase 3 affects expression EXP Furosemide affects the expression of CASP3 mRNA CTD PMID:17497460 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp4 caspase 4 affects expression EXP Furosemide affects the expression of CASP4 mRNA CTD PMID:17497460 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
JBrowse link
G Casp6 caspase 6 affects expression EXP Furosemide affects the expression of CASP6 mRNA CTD PMID:17497460 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Casp8 caspase 8 affects expression EXP Furosemide affects the expression of CASP8 mRNA CTD PMID:17497460 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 affects expression EXP Furosemide affects the expression of CASP9 mRNA CTD PMID:17497460 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cd40 CD40 molecule affects expression EXP Furosemide affects the expression of CD40 mRNA CTD PMID:17497460 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cd70 Cd70 molecule affects expression EXP Furosemide affects the expression of CD70 mRNA CTD PMID:17497460 NCBI chr 9:9,842,585...9,845,728
Ensembl chr 9:9,842,585...9,845,728
JBrowse link
G Cdh5 cadherin 5 decreases expression EXP Furosemide results in decreased expression of CDH5 mRNA CTD PMID:16526316 NCBI chr19:1,025,122...1,074,333
Ensembl chr19:1,023,683...1,074,365
JBrowse link
G Chek1 checkpoint kinase 1 affects expression EXP Furosemide affects the expression of CHEK1 mRNA CTD PMID:17497460 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Chek2 checkpoint kinase 2 affects expression EXP Furosemide affects the expression of CHEK2 mRNA CTD PMID:17497460 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Chga chromogranin A increases expression EXP Furosemide results in increased expression of CHGA mRNA CTD PMID:16526316 NCBI chr 6:126,434,226...126,445,569
Ensembl chr 6:126,434,226...126,445,568
JBrowse link
G Cidea cell death-inducing DFFA-like effector a affects expression EXP Furosemide affects the expression of CIDEA mRNA CTD PMID:17497460 NCBI chr18:63,082,861...63,108,450
Ensembl chr18:63,098,144...63,108,051
JBrowse link
G Cideb cell death-inducing DFFA-like effector b affects expression EXP Furosemide affects the expression of CIDEB mRNA CTD PMID:17497460 NCBI chr15:34,439,844...34,444,244
Ensembl chr15:34,439,876...34,444,244
JBrowse link
G Clcnka chloride voltage-gated channel Ka decreases expression EXP Furosemide results in decreased expression of CLCNKA mRNA CTD PMID:12759757 NCBI chr 5:159,931,497...159,946,483
Ensembl chr 5:159,931,511...159,946,446
JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain decreases expression EXP Furosemide results in decreased expression of COL18A1 mRNA CTD PMID:16526316 NCBI chr20:12,225,202...12,332,858
Ensembl chr20:12,225,202...12,332,858
JBrowse link
G Cradd CASP2 and RIPK1 domain containing adaptor with death domain affects expression EXP Furosemide affects the expression of CRADD mRNA CTD PMID:17497460 NCBI chr 7:36,395,665...36,408,588
Ensembl chr 7:36,395,665...36,408,588
JBrowse link
G Csf3 colony stimulating factor 3 increases expression EXP Furosemide results in increased expression of CSF3 mRNA CTD PMID:16526316 NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157
JBrowse link
G Dapk2 death-associated protein kinase 2 affects expression EXP Furosemide affects the expression of DAPK2 mRNA CTD PMID:17497460 NCBI chr 8:71,822,107...71,941,941
Ensembl chr 8:71,822,129...71,941,910
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Furosemide results in increased expression of DDIT3 mRNA CTD PMID:24813929 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dffa DNA fragmentation factor subunit alpha affects expression EXP Furosemide affects the expression of DFFA mRNA CTD PMID:17497460 NCBI chr 5:165,922,893...165,935,822
Ensembl chr 5:165,922,915...165,935,821
JBrowse link
G Efna5 ephrin A5 increases expression EXP Furosemide results in increased expression of EFNA5 mRNA CTD PMID:16526316 NCBI chr 9:110,054,002...110,329,878
Ensembl chr 9:110,057,155...110,225,486
JBrowse link
G Fadd Fas associated via death domain affects expression EXP Furosemide affects the expression of FADD mRNA CTD PMID:17497460 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
JBrowse link
G Faslg Fas ligand affects expression EXP Furosemide affects the expression of FASLG mRNA CTD PMID:17497460 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fgf16 fibroblast growth factor 16 affects expression EXP Furosemide affects the expression of FGF16 mRNA CTD PMID:16526316 NCBI chr  X:76,786,728...76,796,311
Ensembl chr  X:76,786,466...76,797,069
JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression EXP Furosemide results in decreased expression of FGF2 mRNA CTD PMID:16526316 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgf4 fibroblast growth factor 4 increases expression EXP Furosemide results in increased expression of FGF4 mRNA CTD PMID:16526316 NCBI chr 1:218,024,537...218,029,539
Ensembl chr 1:218,025,810...218,027,220
JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 affects expression EXP Furosemide affects the expression of FGFR4 mRNA CTD PMID:16526316 NCBI chr17:9,990,072...10,004,339
Ensembl chr17:9,990,078...10,004,321
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 increases expression EXP Furosemide results in increased expression of FLT1 mRNA CTD PMID:16526316 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
ISO
EXP
Furosemide results in increased expression of FOS protein
Losartan inhibits the reaction [Furosemide results in increased expression of FOS protein]
CTD PMID:10760498 PMID:15528393 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity EXP Furosemide results in decreased activity of G6PD protein CTD PMID:26820767 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 decreases activity EXP Furosemide results in decreased activity of GABRA4 protein CTD PMID:15613639 NCBI chr14:39,154,072...39,230,994
Ensembl chr14:39,154,529...39,231,695
JBrowse link
G Gad1 glutamate decarboxylase 1 decreases expression EXP Furosemide results in decreased expression of GAD1 mRNA CTD PMID:14596865 NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha affects expression EXP Furosemide affects the expression of GADD45A mRNA CTD PMID:17497460 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions EXP [Drinking Water deficiency co-treated with Furosemide co-treated with iodixanol] results in decreased expression of GCLM mRNA; [Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in decreased expression of GCLM mRNA CTD PMID:29860548 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP Furosemide results in decreased activity of GSR protein CTD PMID:26820767 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP [Drinking Water deficiency co-treated with Furosemide co-treated with iodixanol] results in increased expression of HMGB1 protein; [Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in increased expression of HMGB1 protein CTD PMID:29860548 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO
EXP
Furosemide results in increased expression of HMOX1 mRNA
[Drinking Water deficiency co-treated with Furosemide co-treated with iodixanol] results in increased expression of HMOX1 mRNA; [Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in increased expression of HMOX1 mRNA
CTD PMID:24813929 PMID:29860548 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hrk harakiri, BCL2 interacting protein affects expression EXP Furosemide affects the expression of HRK mRNA CTD PMID:17497460 NCBI chr12:44,008,879...44,029,211 JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases activity EXP Furosemide results in decreased activity of HSD11B1 protein CTD PMID:11749789 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
JBrowse link
G Hus1 HUS1 checkpoint clamp component affects expression EXP Furosemide affects the expression of HUS1 mRNA CTD PMID:17497460 NCBI chr14:89,194,086...89,208,825
Ensembl chr14:89,194,092...89,208,825
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein decreases expression EXP Furosemide results in decreased expression of ID1 mRNA CTD PMID:16526316 NCBI chr 3:148,214,623...148,216,715
Ensembl chr 3:148,215,540...148,216,718
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein decreases expression EXP Furosemide results in decreased expression of ID3 mRNA CTD PMID:16526316 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
JBrowse link
G Ifna1 interferon, alpha 1 increases expression EXP Furosemide results in increased expression of IFNA1 mRNA CTD PMID:16526316 NCBI chr 5:106,951,822...106,952,908
Ensembl chr 5:106,952,082...106,952,792
JBrowse link
G Igf1 insulin-like growth factor 1 increases expression EXP Furosemide results in increased expression of IGF1 mRNA CTD PMID:16526316 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Il10 interleukin 10 decreases secretion ISO Furosemide results in decreased secretion of IL10 protein CTD PMID:16612254 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il6 interleukin 6 decreases secretion ISO Furosemide results in decreased secretion of IL6 protein CTD PMID:16612254 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itga5 integrin subunit alpha 5 decreases expression EXP Furosemide results in decreased expression of ITGA5 mRNA CTD PMID:16526316 NCBI chr 7:144,970,444...144,993,652
Ensembl chr 7:144,970,444...144,993,652
JBrowse link
G Kdr kinase insert domain receptor increases expression EXP Furosemide results in increased expression of KDR mRNA CTD PMID:16526316 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Lta lymphotoxin alpha affects expression EXP Furosemide affects the expression of LTA mRNA CTD PMID:17497460 NCBI chr20:4,851,889...4,854,677
Ensembl chr20:4,852,496...4,854,677
JBrowse link
G Ltb lymphotoxin beta affects expression EXP Furosemide affects the expression of LTB mRNA CTD PMID:17497460 NCBI chr20:5,184,631...5,186,476
Ensembl chr20:5,184,515...5,186,503
JBrowse link
G Ltbr lymphotoxin beta receptor affects expression EXP Furosemide affects the expression of LTBR mRNA CTD PMID:17497460 NCBI chr 4:157,822,838...157,829,291
Ensembl chr 4:157,822,840...157,829,241
JBrowse link
G Mdk midkine increases expression EXP Furosemide results in increased expression of MDK mRNA CTD PMID:16526316 NCBI chr 3:80,841,003...80,843,895
Ensembl chr 3:80,841,005...80,842,916
JBrowse link
G Mdm2 MDM2 proto-oncogene affects expression EXP Furosemide affects the expression of MDM2 mRNA CTD PMID:17497460 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Msr1 macrophage scavenger receptor 1 increases expression EXP Furosemide results in increased expression of MSR1 mRNA CTD PMID:16526316 NCBI chr16:56,817,714...56,900,025
Ensembl chr16:56,813,791...56,900,052
JBrowse link
G Mt1 metallothionein 1 increases expression ISO Furosemide results in increased expression of MT1 mRNA CTD PMID:24813929 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 affects expression EXP Furosemide affects the expression of NAIP2 mRNA CTD PMID:17497460 NCBI chr 2:30,377,505...30,418,578 JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases localization
decreases response to substance
ISO Furosemide results in increased localization of NFE2L2 protein
NFE2L2 protein results in decreased susceptibility to Furosemide
CTD PMID:18078705 PMID:24813929 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP [Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in increased expression of NLRP3 protein CTD PMID:29860548 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Nol3 nucleolar protein 3 affects expression EXP Furosemide affects the expression of NOL3 mRNA CTD PMID:17497460 NCBI chr19:37,232,567...37,236,668
Ensembl chr19:37,235,001...37,236,649
JBrowse link
G Nos3 nitric oxide synthase 3 affects expression EXP Furosemide affects the expression of NOS3 mRNA CTD PMID:16526316 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nppa natriuretic peptide A decreases expression ISO Furosemide results in decreased expression of NPPA protein CTD PMID:2146706 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP [Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in decreased expression of NQO1 mRNA CTD PMID:29860548 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Pdgfra platelet derived growth factor receptor alpha affects expression EXP Furosemide affects the expression of PDGFRA mRNA CTD PMID:16526316 NCBI chr14:35,527,926...35,581,130
Ensembl chr14:35,527,927...35,581,031
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta increases expression EXP Furosemide results in increased expression of PDGFRB mRNA CTD PMID:16526316 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 increases expression EXP Furosemide results in increased expression of PECAM1 mRNA CTD PMID:16526316 NCBI chr10:94,850,971...94,913,202 JBrowse link
G Pf4 platelet factor 4 decreases expression EXP Furosemide results in decreased expression of PF4 mRNA CTD PMID:16526316 NCBI chr14:18,848,549...18,849,258
Ensembl chr14:18,848,549...18,849,258
JBrowse link
G Pgd phosphogluconate dehydrogenase decreases activity EXP Furosemide results in decreased activity of PGD protein CTD PMID:26820767 NCBI chr 5:165,966,128...165,982,327 JBrowse link
G Pgf placental growth factor decreases expression EXP Furosemide results in decreased expression of PGF mRNA CTD PMID:16526316 NCBI chr 6:108,994,016...109,004,598
Ensembl chr 6:108,994,018...109,004,598
JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions EXP [Drinking Water deficiency co-treated with Furosemide co-treated with iodixanol] results in increased expression of PINK1 protein CTD PMID:29860548 NCBI chr 5:156,677,146...156,689,258
Ensembl chr 5:156,677,146...156,689,415
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions EXP [Drinking Water deficiency co-treated with Furosemide co-treated with iodixanol] results in increased expression of PRKN protein CTD PMID:29860548 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Ptger4 prostaglandin E receptor 4 multiple interactions ISO PTGER4 protein affects the reaction [Furosemide results in increased expression of REN mRNA]; PTGER4 protein affects the reaction [Furosemide results in increased expression of REN protein] CTD PMID:15976003 NCBI chr 2:54,951,625...54,966,470
Ensembl chr 2:54,952,821...54,963,448
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 affects expression EXP Furosemide affects the expression of PTGS1 mRNA; Furosemide affects the expression of PTGS1 protein CTD PMID:11961000 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 affects expression
multiple interactions
increases expression
EXP Furosemide affects the expression of PTGS2 mRNA; Furosemide affects the expression of PTGS2 protein
[Furosemide results in increased expression of PTGS2 mRNA] which results in increased abundance of Prostaglandins; [rofecoxib results in decreased activity of PTGS2 protein] inhibits the reaction [Furosemide results in increased abundance of Prostaglandins]
Furosemide results in increased expression of PTGS2 mRNA; Furosemide results in increased expression of PTGS2 protein
CTD PMID:11135058 PMID:11703585 PMID:11961000 PMID:19031110 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Pth parathyroid hormone increases expression
multiple interactions
EXP Furosemide results in increased expression of PTH protein
NPS R-467 inhibits the reaction [Furosemide results in increased expression of PTH protein]
CTD PMID:15086907 NCBI chr 1:178,215,829...178,218,761
Ensembl chr 1:178,215,829...178,218,761
JBrowse link
G Ptn pleiotrophin affects expression EXP Furosemide affects the expression of PTN mRNA CTD PMID:16526316 NCBI chr 4:64,239,156...64,330,996
Ensembl chr 4:64,239,158...64,330,996
JBrowse link
G Ren renin multiple interactions
increases expression
increases secretion
increases activity
ISO
EXP
Furosemide inhibits the reaction [Ethinyl Estradiol results in increased expression of REN protein]; Indomethacin inhibits the reaction [Furosemide results in increased expression of REN protein]; Ketoprofen inhibits the reaction [Furosemide results in increased activity of REN protein]; Sulindac inhibits the reaction [Furosemide results in increased expression of REN protein]
Furosemide results in increased secretion of REN protein
Furosemide results in increased expression of REN mRNA; Furosemide results in increased expression of REN protein
PTGER4 protein affects the reaction [Furosemide results in increased expression of REN mRNA]; PTGER4 protein affects the reaction [Furosemide results in increased expression of REN protein]
CTD PMID:599795 PMID:1924052 PMID:3530574 PMID:4028619 PMID:7954537 PMID:8418022 PMID:10604960 PMID:11046100 PMID:11095476 PMID:11135058 PMID:15976003 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 affects expression EXP Furosemide affects the expression of RIPK1 mRNA CTD PMID:17497460 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link
G Rpa3 replication protein A3 affects expression EXP Furosemide affects the expression of RPA3 mRNA CTD PMID:17497460 NCBI chr 4:34,279,320...34,282,351
Ensembl chr 4:34,279,320...34,282,351
JBrowse link
G S100b S100 calcium binding protein B multiple interactions EXP [Furosemide results in decreased activity of SLC12A2 protein] affects the reaction [Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein]]; [Furosemide results in decreased activity of SLC12A2 protein] inhibits the reaction [Ammonia results in increased secretion of S100B protein] CTD PMID:23880158 NCBI chr20:13,130,633...13,142,856
Ensembl chr20:13,130,636...13,142,856
JBrowse link
G S100g S100 calcium binding protein G affects expression ISO Furosemide affects the expression of S100G mRNA CTD PMID:17652376 NCBI chr  X:33,442,820...33,445,714
Ensembl chr  X:33,443,186...33,445,709
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 increases expression EXP Furosemide results in increased expression of S1PR1 mRNA CTD PMID:16526316 NCBI chr 2:218,654,406...218,658,761
Ensembl chr 2:218,654,554...218,658,761
JBrowse link
G Serpinb5 serpin family B member 5 increases expression EXP Furosemide results in increased expression of SERPINB5 mRNA CTD PMID:16526316 NCBI chr13:26,903,052...26,923,250
Ensembl chr13:26,903,052...26,923,250
JBrowse link
G Serpinf1 serpin family F member 1 affects expression EXP Furosemide affects the expression of SERPINF1 mRNA CTD PMID:16526316 NCBI chr10:62,241,750...62,254,145
Ensembl chr10:62,241,756...62,254,287
JBrowse link
G Slc12a1 solute carrier family 12 member 1 decreases activity ISO Furosemide results in decreased activity of SLC12A1 protein CTD PMID:11249848 NCBI chr 3:117,421,531...117,498,372
Ensembl chr 3:117,421,604...117,498,367
JBrowse link
G Slc12a2 solute carrier family 12 member 2 multiple interactions
decreases activity
EXP
ISO
[Furosemide results in decreased activity of SLC12A2 protein] affects the reaction [Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein]]; [Furosemide results in decreased activity of SLC12A2 protein] inhibits the reaction [Ammonia results in increased secretion of S100B protein]; [Furosemide results in decreased activity of SLC12A2 protein] promotes the reaction [Thioctic Acid results in decreased activity of Ammonia]; [Furosemide results in decreased activity of SLC12A2 protein] which results in decreased susceptibility to Ammonia; [Furosemide results in decreased activity of SLC12A2 protein] which results in increased activity of Ammonia
Furosemide inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium]
CTD PMID:23880158 PMID:29959396 NCBI chr18:52,917,124...52,985,281
Ensembl chr18:52,917,124...52,985,261
JBrowse link
G Slc12a5 solute carrier family 12 member 5 decreases activity
multiple interactions
EXP
ISO
Furosemide results in decreased activity of SLC12A5 protein
Furosemide inhibits the reaction [SLC12A5 protein results in increased import of Thallium]
CTD PMID:18094240 PMID:20086212 NCBI chr 3:161,433,303...161,465,078
Ensembl chr 3:161,425,988...161,462,879
JBrowse link
G Slc12a7 solute carrier family 12 member 7 decreases activity ISO Furosemide results in decreased activity of SLC12A7 protein CTD PMID:10913127 NCBI chr 1:32,086,755...32,167,950
Ensembl chr 1:32,086,755...32,141,036
JBrowse link
G Slc22a6 solute carrier family 22 member 6 increases expression
increases secretion
decreases activity
EXP
ISO
Furosemide results in increased expression of SLC22A6 protein
SLC22A6 protein results in increased secretion of Furosemide
Furosemide results in decreased activity of SLC22A6 protein
CTD PMID:12897087 PMID:18216144 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions ISO Furosemide inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline] CTD PMID:15901346 NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766
JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases activity
multiple interactions
increases secretion
ISO
EXP
Furosemide results in decreased activity of SLC22A8 protein
Furosemide inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]
Furosemide inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]
SLC22A8 protein results in increased secretion of Furosemide
CTD PMID:10224140 PMID:11306713 PMID:18216144 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link
G Slc26a4 solute carrier family 26 member 4 multiple interactions
affects localization
EXP [Furosemide co-treated with Amiloride] affects the localization of SLC26A4 protein
Furosemide affects the localization of SLC26A4 protein
CTD PMID:17311909 NCBI chr 6:50,809,103...50,848,443
Ensembl chr 6:50,808,923...50,846,965
JBrowse link
G Sparc secreted protein acidic and cysteine rich increases expression EXP Furosemide results in increased expression of SPARC mRNA CTD PMID:16526316 NCBI chr10:40,742,390...40,764,232
Ensembl chr10:40,742,400...40,764,185
JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 increases expression EXP Furosemide results in increased expression of SPINK1 mRNA CTD PMID:28138970 NCBI chr18:38,221,919...38,242,092
Ensembl chr18:38,221,681...38,242,119
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP [Drinking Water deficiency co-treated with Furosemide] results in increased expression of SQSTM1 protein; iodixanol inhibits the reaction [[Drinking Water deficiency co-treated with Furosemide] results in increased expression of SQSTM1 protein]; Iohexol inhibits the reaction [[Drinking Water deficiency co-treated with Furosemide] results in increased expression of SQSTM1 protein] CTD PMID:29860548 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Tek TEK receptor tyrosine kinase increases expression EXP Furosemide results in increased expression of TEK mRNA CTD PMID:16526316 NCBI chr 5:113,725,717...113,852,799
Ensembl chr 5:113,725,717...113,852,799
JBrowse link
G Tgfa transforming growth factor alpha increases expression EXP Furosemide results in increased expression of TGFA mRNA CTD PMID:16526316 NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344
JBrowse link
G Tgfb1 transforming growth factor, beta 1 affects expression EXP Furosemide affects the expression of TGFB1 protein CTD PMID:18001696 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression EXP Furosemide results in increased expression of TGFB2 mRNA CTD PMID:16526316 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 increases expression EXP Furosemide results in increased expression of TGFBR1 mRNA CTD PMID:16526316 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 increases expression EXP Furosemide results in increased expression of TGFBR2 mRNA CTD PMID:16526316 NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494
JBrowse link
G Thbs1 thrombospondin 1 affects expression EXP Furosemide affects the expression of THBS1 mRNA CTD PMID:16526316 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
G Thbs2 thrombospondin 2 increases expression EXP Furosemide results in increased expression of THBS2 mRNA CTD PMID:16526316 NCBI chr 1:56,653,929...56,683,571
Ensembl chr 1:56,653,938...56,683,731
JBrowse link
G Thbs3 thrombospondin 3 affects expression EXP Furosemide affects the expression of THBS3 mRNA CTD PMID:16526316 NCBI chr 2:188,528,979...188,540,738
Ensembl chr 2:188,528,979...188,540,736
JBrowse link
G Thbs4 thrombospondin 4 affects expression EXP Furosemide affects the expression of THBS4 mRNA CTD PMID:16526316 NCBI chr 2:22,343,727...22,385,855
Ensembl chr 2:22,343,727...22,385,855
JBrowse link
G Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 increases expression EXP Furosemide results in increased expression of TIE1 mRNA CTD PMID:16526316 NCBI chr 5:137,294,544...137,321,116
Ensembl chr 5:137,294,544...137,321,121
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 affects expression EXP Furosemide affects the expression of TIMP2 mRNA CTD PMID:16526316 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
JBrowse link
G Tnf tumor necrosis factor decreases secretion
affects expression
ISO
EXP
Furosemide results in decreased secretion of TNF protein
Furosemide affects the expression of TNF mRNA
CTD PMID:16526316 PMID:16612254 PMID:17497460 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf11a TNF receptor superfamily member 11A affects expression EXP Furosemide affects the expression of TNFRSF11A mRNA CTD PMID:17497460 NCBI chr13:25,778,306...25,835,802
Ensembl chr13:25,778,317...25,835,957
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A affects expression EXP Furosemide affects the expression of TNFRSF1A mRNA CTD PMID:17497460 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B affects expression EXP Furosemide affects the expression of TNFRSF1B mRNA CTD PMID:17497460 NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299
JBrowse link
G Tnfrsf25 TNF receptor superfamily member 25 affects expression EXP Furosemide affects the expression of TNFRSF25 mRNA CTD PMID:17497460 NCBI chr 5:169,288,419...169,293,137
Ensembl chr 5:169,288,871...169,293,137
JBrowse link
G Tnfrsf8 TNF receptor superfamily member 8 affects expression EXP Furosemide affects the expression of TNFRSF8 mRNA CTD PMID:17497460 NCBI chr 5:163,186,349...163,231,578
Ensembl chr 5:163,186,349...163,231,578
JBrowse link
G Tnfrsf9 TNF receptor superfamily member 9 affects expression EXP Furosemide affects the expression of TNFRSF9 mRNA CTD PMID:17497460 NCBI chr 5:168,009,245...168,035,813
Ensembl chr 5:168,009,393...168,035,810
JBrowse link
G Tnfsf10 TNF superfamily member 10 affects expression EXP Furosemide affects the expression of TNFSF10 mRNA CTD PMID:17497460 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tnfsf11 TNF superfamily member 11 affects expression EXP Furosemide affects the expression of TNFSF11 mRNA CTD PMID:17497460 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Tnfsf12 TNF superfamily member 12 affects expression EXP Furosemide affects the expression of TNFSF12 mRNA CTD PMID:17497460 NCBI chr10:56,290,780...56,300,137
Ensembl chr10:56,290,780...56,300,077
JBrowse link
G Tnfsf13 TNF superfamily member 13 affects expression EXP Furosemide affects the expression of TNFSF13 mRNA CTD PMID:17497460 NCBI chr10:56,286,964...56,290,680
Ensembl chr10:56,286,887...56,289,952
JBrowse link
G Tnfsf8 TNF superfamily member 8 affects expression EXP Furosemide affects the expression of TNFSF8 mRNA CTD PMID:17497460 NCBI chr 5:79,664,779...79,691,547
Ensembl chr 5:79,664,765...79,691,258
JBrowse link
G Tnfsf9 TNF superfamily member 9 affects expression EXP Furosemide affects the expression of TNFSF9 mRNA CTD PMID:17497460 NCBI chr 9:9,909,942...9,912,276
Ensembl chr 9:9,909,948...9,912,276
JBrowse link
G Tpmt thiopurine S-methyltransferase decreases activity ISO Furosemide results in decreased activity of TPMT protein CTD PMID:8866635 NCBI chr17:18,029,090...18,047,716
Ensembl chr17:18,029,124...18,047,714
JBrowse link
G Traf5 TNF receptor-associated factor 5 affects expression EXP Furosemide affects the expression of TRAF5 mRNA CTD PMID:17497460 NCBI chr13:110,758,556...110,801,871
Ensembl chr13:110,758,761...110,784,209
JBrowse link
G Traf6 TNF receptor associated factor 6 affects expression EXP Furosemide affects the expression of TRAF6 mRNA CTD PMID:17497460 NCBI chr 3:91,252,829...91,271,607
Ensembl chr 3:91,252,829...91,271,607
JBrowse link
G Trpv5 transient receptor potential cation channel, subfamily V, member 5 increases expression ISO Furosemide results in increased expression of TRPV5 mRNA; Furosemide results in increased expression of TRPV5 protein CTD PMID:17652376 NCBI chr 4:70,947,615...70,974,004
Ensembl chr 4:70,947,717...70,974,006
JBrowse link
G Trpv6 transient receptor potential cation channel, subfamily V, member 6 increases expression ISO Furosemide results in increased expression of TRPV6 mRNA CTD PMID:17652376 NCBI chr 4:70,918,631...70,934,291
Ensembl chr 4:70,918,632...70,934,295
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO Furosemide results in increased expression of UGT1A1 mRNA CTD PMID:18227147 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Furosemide CTD PMID:15117964 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of Furosemide CTD PMID:15117964 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression EXP Furosemide results in increased expression of VCAM1 mRNA CTD PMID:16526316 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vegfa vascular endothelial growth factor A affects expression EXP Furosemide affects the expression of VEGFA mRNA CTD PMID:16526316 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vegfc vascular endothelial growth factor C increases expression EXP Furosemide results in increased expression of VEGFC mRNA CTD PMID:16526316 NCBI chr16:40,440,371...40,555,178
Ensembl chr16:40,440,207...40,555,576
JBrowse link
G Xiap X-linked inhibitor of apoptosis affects expression EXP Furosemide affects the expression of XIAP mRNA CTD PMID:17497460 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
N-(2,6-diethylphenyl)-2-chloroacetamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 multiple interactions
increases abundance
increases chemical synthesis
ISO [CYP3A4 protein results in increased metabolism of alachlor] which results in increased abundance of 2-chloro-N-(2,6-diethylphenyl)acetamide
CYP3A4 protein results in increased abundance of 2-chloro-N-(2,6-diethylphenyl)acetamide
CYP3A4 protein results in increased chemical synthesis of 2-chloro-N-(2,6-diethylphenyl)acetamide
CTD PMID:10475613 PMID:18273908 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19883
    role 19833
      chemical role 19351
        donor 18483
          Bronsted acid 18336
            oxoacid 18286
              carbon oxoacid 18164
                carboxylic acid 18153
                  chlorocarboxylic acid 194
                    (S)-2-chloropropanoic acid 0
                    2-chloroacrylic acid 0
                    2-chlorosuccinic acid 0
                    3-chloroacrylic acid + 0
                    4,4'-dichlorobenzilic acid + 4
                    5-chloromuconolactone 0
                    chloroacetic acid + 29
                    chlorobenzoic acid + 169
                    chloromuconic acid + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19883
    subatomic particle 19881
      composite particle 19881
        hadron 19881
          baryon 19881
            nucleon 19881
              atomic nucleus 19881
                atom 19881
                  main group element atom 19771
                    p-block element atom 19771
                      carbon group element atom 19679
                        carbon atom 19668
                          organic molecular entity 19668
                            organic group 18580
                              organic divalent group 18571
                                organodiyl group 18571
                                  carbonyl group 18479
                                    carbonyl compound 18479
                                      carboxylic acid 18153
                                        chlorocarboxylic acid 194
                                          (S)-2-chloropropanoic acid 0
                                          2-chloroacrylic acid 0
                                          2-chlorosuccinic acid 0
                                          3-chloroacrylic acid + 0
                                          4,4'-dichlorobenzilic acid + 4
                                          5-chloromuconolactone 0
                                          chloroacetic acid + 29
                                          chlorobenzoic acid + 169
                                          chloromuconic acid + 0
paths to the root