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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pyrithione
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Accession:CHEBI:36578 term browser browse the term
Definition:A pyridinethione that is pyridine-2(1H)-thione in which the hydrogen attached to the nitrogen is replaced by a hydroxy group. It is a Zn(2+) ionophore; the zinc salt is used as an antifungal and antibacterial agent.
Synonyms:exact_synonym: 1-hydroxypyridine-2(1H)-thione
 related_synonym: 1-hydroxy-2-pyridinethione;   1-hydroxyl-1H-pyridine-2-thione;   1-hydroxypyridine-2-thione;   Formula=C5H5NOS;   InChI=1S/C5H5NOS/c7-6-4-2-1-3-5(6)8/h1-4,7H;   InChIKey=YBBJKCMMCRQZMA-UHFFFAOYSA-N;   SMILES=On1ccccc1=S
 xref: Beilstein:109936;   CAS:1121-30-8;   Gmelin:913415
 xref_mesh: MESH:C008704
 xref: PMID:19967345;   Reaxys:109936
 cyclic_relationship: is_tautomer_of CHEBI:36584

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pyrithione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [Zinc co-treated with pyrithione] results in increased phosphorylation of and results in increased activity of AKT1 protein; AKT1 protein promotes the reaction [[Zinc co-treated with pyrithione] results in increased phosphorylation of and results in increased activity of GSK3B protein] CTD PMID:17098228 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Cd14 CD14 molecule multiple interactions ISO [Zinc co-treated with pyrithione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of CD14 protein]]; pyrithione promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of CD14 protein]] CTD PMID:20089671 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153 		JBrowse link
G Cd86 CD86 molecule multiple interactions ISO pyrithione inhibits the reaction [Lipopolysaccharides results in increased expression of CD86] CTD PMID:17126599 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795 		JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 multiple interactions ISO 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole inhibits the reaction [[Zinc co-treated with pyrithione] promotes the reaction [CSNK2A1 protein binds to SLC39A7 protein]]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [[Zinc co-treated with pyrithione] promotes the reaction [CSNK2A1 protein binds to SLC39A7 protein]]; [Zinc co-treated with pyrithione] promotes the reaction [CSNK2A1 protein binds to SLC39A7 protein] CTD PMID:22317921 NCBI chr 3:147,713,808...147,760,375
Ensembl chr 3:147,713,821...147,757,862 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP [Zinc co-treated with pyrithione] results in increased cleavage of CTNNB1 protein CTD PMID:17098228 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP [Zinc co-treated with pyrithione] results in increased phosphorylation of and results in increased activity of GSK3B protein; AKT1 protein promotes the reaction [[Zinc co-treated with pyrithione] results in increased phosphorylation of and results in increased activity of GSK3B protein]; GSK3B protein promotes the reaction [[Zinc co-treated with pyrithione] results in increased phosphorylation of MAPT protein] CTD PMID:17098228 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268 		JBrowse link
G Hgf hepatocyte growth factor multiple interactions ISO [Zinc co-treated with pyrithione] promotes the reaction [HGF protein results in increased expression of PCNA mRNA] CTD PMID:22374166 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO pyrithione analog results in increased expression of HMOX1 mRNA CTD PMID:23085594 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO [Zinc co-treated with pyrithione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of ITGAM protein]]; pyrithione promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of ITGAM protein]] CTD PMID:20089671 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Zinc co-treated with pyrithione] results in increased phosphorylation of MAPK1 protein CTD PMID:20201035 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Zinc co-treated with pyrithione] results in increased phosphorylation of MAPK3 protein CTD PMID:20201035 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions EXP [Zinc co-treated with pyrithione] results in increased phosphorylation of MAPT protein; GSK3B protein promotes the reaction [[Zinc co-treated with pyrithione] results in increased phosphorylation of MAPT protein] CTD PMID:17098228 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517 		JBrowse link
G Mt1 metallothionein 1 increases expression ISO pyrithione analog results in increased expression of MT1 mRNA CTD PMID:23085594 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO [Zinc co-treated with pyrithione] promotes the reaction [HGF protein results in increased expression of PCNA mRNA] CTD PMID:22374166 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions ISO [Zinc co-treated with pyrithione] results in decreased activity of PTPN1 protein CTD PMID:22374166 NCBI chr 3:164,665,462...164,711,936
Ensembl chr 3:164,665,532...164,711,848 		JBrowse link
G Slc39a7 solute carrier family 39 member 7 multiple interactions ISO 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole inhibits the reaction [[Zinc co-treated with pyrithione] promotes the reaction [CSNK2A1 protein binds to SLC39A7 protein]]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [[Zinc co-treated with pyrithione] promotes the reaction [CSNK2A1 protein binds to SLC39A7 protein]]; [Zinc co-treated with pyrithione] promotes the reaction [CSNK2A1 protein binds to SLC39A7 protein] CTD PMID:22317921 NCBI chr20:3,819,416...3,822,788
Ensembl chr20:3,819,414...3,822,778 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    role 19825
      biological role 19825
        biophysical role 12669
          membrane transport modulator 12467
            ionophore 1187
              pyrithione 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      carbon group element atom 19668
                        carbon atom 19657
                          organic molecular entity 19657
                            organic molecule 19586
                              organic cyclic compound 19395
                                organic heterocyclic compound 18511
                                  organic heteromonocyclic compound 16621
                                    pyridines 8424
                                      hydroxypyridine 66
                                        monohydroxypyridine 50
                                          pyrithione 16
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