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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:zinc group coordination entity
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Accession:CHEBI:36563 term browser browse the term
Synonyms:related_synonym: zinc group coordination compounds;   zinc group coordination entities


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cadmium dichloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of AKT1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased phosphorylation of AKT1 protein CTD PMID:33493553
G ALOX15 arachidonate 15-lipoxygenase increases expression EXP Cadmium Chloride results in increased expression of ALOX15 mRNA CTD PMID:33626375 NCBI chr12:52,287,174...52,295,873
Ensembl chr12:52,286,019...52,414,907
JBrowse link
G ALOX5 arachidonate 5-lipoxygenase increases expression EXP Cadmium Chloride results in increased expression of ALOX5 mRNA CTD PMID:33626375 NCBI chr14:90,859,209...90,907,084
Ensembl chr14:90,858,975...90,907,094
JBrowse link
G AQP1 aquaporin 1 (Colton blood group) increases expression EXP Cadmium Chloride results in increased expression of AQP1 mRNA CTD PMID:20576581 NCBI chr18:42,063,482...42,076,741
Ensembl chr18:42,063,481...42,076,746
JBrowse link
G ATF4 activating transcription factor 4 multiple interactions
increases expression
EXP Cycloheximide inhibits the reaction [Cadmium Chloride results in increased expression of ATF4 protein]
Cadmium Chloride results in increased expression of ATF4; Cadmium Chloride results in increased expression of ATF4 mRNA; Cadmium Chloride results in increased expression of ATF4 protein
CTD PMID:16759985 PMID:20600546 NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,738,880...8,745,225
JBrowse link
G ATF6 activating transcription factor 6 increases cleavage
multiple interactions
EXP Cadmium Chloride results in increased cleavage of ATF6 protein
4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [Cadmium Chloride results in increased cleavage of ATF6 protein]
CTD PMID:17464326 NCBI chr 4:88,591,279...88,806,156
Ensembl chr 4:88,591,280...88,818,372
JBrowse link
G BAK1 BCL2 antagonist/killer 1 multiple interactions
increases expression
EXP [Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAK1 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAK1 mRNA; MIR125A mRNA inhibits the reaction [Cadmium Chloride results in increased expression of BAK1 protein]; Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAK1 protein]; Sodium Selenite inhibits the reaction [Cadmium Chloride results in increased expression of BAK1 protein] CTD PMID:26607349 PMID:33493553 NCBI chr 7:29,808,849...29,815,345 JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression
multiple interactions
EXP Cadmium Chloride results in increased expression of BAX protein
[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAX protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein; MIR125A mRNA inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]; Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAX protein]; Sodium Selenite inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]
CTD PMID:26607349 PMID:33493553 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,187,260...54,228,144
JBrowse link
G BCL2 BCL2 apoptosis regulator increases expression
decreases expression
multiple interactions
EXP Cadmium Chloride results in increased expression of BCL2 protein
Cadmium Chloride results in decreased expression of BCL2 protein
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 protein; Cadmium Chloride promotes the reaction [MIR125A mRNA mutant form results in decreased expression of BCL2 protein]; MIR125A mRNA inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein]; Sodium Selenite inhibits the reaction [Cadmium Chloride promotes the reaction [MIR125A mRNA mutant form results in decreased expression of BCL2 protein]]; Sodium Selenite inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein]
CTD PMID:23575899 PMID:26607349 PMID:33493553 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,288,544...158,518,879
JBrowse link
G CASP1 caspase 1, apoptosis-related cysteine peptidase multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP1 protein CTD PMID:33592257 NCBI chr 9:35,188,066...35,199,364
Ensembl chr 9:35,186,420...35,200,328
JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity
increases expression
increases cleavage
EXP [Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of CASP3 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP3 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP3 protein; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]; MIR125A mRNA inhibits the reaction [Cadmium Chloride results in increased expression of CASP3 protein]; oxalomalic acid promotes the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]; Selenium inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]; Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of CASP3 protein]; Sodium Selenite inhibits the reaction [Cadmium Chloride results in increased expression of CASP3 protein] CTD PMID:16785314 PMID:17383151 PMID:26607349 PMID:33493553 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CASP9 caspase 9 increases expression
multiple interactions
EXP Cadmium Chloride results in increased expression of CASP9 protein
[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of CASP9 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP9 mRNA; MIR125A mRNA inhibits the reaction [Cadmium Chloride results in increased expression of CASP9 protein]; Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of CASP9 protein]; Sodium Selenite inhibits the reaction [Cadmium Chloride results in increased expression of CASP9 protein]
CTD PMID:26607349 PMID:33493553 NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,515...74,730,092
JBrowse link
G CAT catalase decreases activity
decreases expression
multiple interactions
EXP Cadmium Chloride results in decreased activity of CAT protein
Cadmium Chloride results in decreased expression of CAT mRNA
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of CAT protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CAT mRNA; CAT inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 mRNA]
CTD PMID:18086661 PMID:23904328 PMID:33493553 PMID:33626375 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G CLIC5 chloride intracellular channel 5 decreases expression
multiple interactions
increases degradation
EXP Cadmium Chloride results in decreased expression of CLIC5 mRNA; Cadmium Chloride results in decreased expression of CLIC5 protein
bafilomycin A inhibits the reaction [Cadmium Chloride results in decreased expression of CLIC5 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Cadmium Chloride results in decreased expression of CLIC5 protein]; Cycloheximide promotes the reaction [Cadmium Chloride results in decreased expression of CLIC5 protein]
Cadmium Chloride results in increased degradation of CLIC5 protein
CTD PMID:20576581 NCBI chr 7:40,683,044...40,808,017
Ensembl chr 7:40,682,907...40,863,886
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases expression EXP Cadmium Chloride results in increased expression of CXCL8 mRNA CTD PMID:33626375 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861
JBrowse link
G CYCS cytochrome c, somatic multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CYCS mRNA CTD PMID:33493553 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866
JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases expression
multiple interactions
EXP Cadmium Chloride results in increased expression of DDIT3 mRNA
4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 mRNA]; SOD2 inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 mRNA]
CTD PMID:17464326 PMID:18086661 NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,441...22,791,134
JBrowse link
G DENR density regulated re-initiation and release factor multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of DENR mRNA CTD PMID:33592257 NCBI chr14:30,070,810...30,084,997
Ensembl chr14:30,069,485...30,084,949
JBrowse link
G DNM1L dynamin 1 like multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of DNM1L mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of DNM1L protein CTD PMID:33493553 NCBI chr 5:41,571,054...41,636,058 JBrowse link
G EGR1 early growth response 1 increases expression EXP Cadmium Chloride results in increased expression of EGR1 mRNA CTD PMID:7564105 NCBI chr 2:140,440,829...140,445,302
Ensembl chr 2:140,441,421...140,445,296
JBrowse link
G EIF2A eukaryotic translation initiation factor 2A increases phosphorylation EXP Cadmium Chloride results in increased phosphorylation of EIF2A protein CTD PMID:16759985 PMID:17464326 NCBI chr13:90,761,453...90,804,274
Ensembl chr13:90,761,465...90,804,276
JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation EXP Cadmium Chloride results in increased phosphorylation of EIF2AK3 protein CTD PMID:17464326 NCBI chr 3:57,423,894...57,506,247
Ensembl chr 3:57,423,875...57,506,247
JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation EXP Cadmium Chloride results in increased phosphorylation of EIF2S1 protein CTD PMID:20600546 NCBI chr 7:91,085,025...91,109,835
Ensembl chr 7:91,085,335...91,109,829
JBrowse link
G FIS1 fission, mitochondrial 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of FIS1 mRNA CTD PMID:33592257 NCBI chr 3:8,938,250...8,942,102
Ensembl chr 3:8,931,104...8,941,865
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
EXP Cadmium Chloride results in increased expression of FOS mRNA
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA]
CTD PMID:7564105 PMID:18086661 NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of GCLC mRNA CTD PMID:33493553 NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,564...27,253,535
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of GCLM mRNA CTD PMID:33493553 NCBI chr 4:123,371,198...123,390,130
Ensembl chr 4:123,371,193...123,390,135
JBrowse link
G GLRX glutaredoxin decreases activity
multiple interactions
EXP Cadmium Chloride results in decreased activity of GLRX protein
GLRX protein inhibits the reaction [Cadmium Chloride results in increased cleavage of PARP1 protein]; IDH2 protein inhibits the reaction [Cadmium Chloride results in decreased activity of GLRX protein]; oxalomalic acid promotes the reaction [Cadmium Chloride results in decreased activity of GLRX protein]
CTD PMID:16785314 NCBI chr 2:102,425,580...102,437,851 JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions
decreases expression
EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of GPX1 mRNA
Cadmium Chloride results in decreased expression of GPX1 mRNA
CTD PMID:33493553 PMID:33626375 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,914,932...31,917,335
JBrowse link
G GPX4 glutathione peroxidase 4 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of GPX4 mRNA CTD PMID:33493553 NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,886
JBrowse link
G GSTO1 glutathione S-transferase omega 1 decreases expression EXP Cadmium Chloride results in decreased expression of GSTO1 mRNA CTD PMID:33626375 NCBI chr14:115,206,434...115,216,624
Ensembl chr14:115,206,188...115,216,613
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of HIF1A mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of HIF1A protein CTD PMID:33493553 NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,181...190,674,850
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of HMOX1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HMOX1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HMOX1 protein CTD PMID:33493553 PMID:33592257
G HSP90B1 heat shock protein 90 beta family member 1 multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HSP90B1 mRNA] CTD PMID:17464326 PMID:18086661 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,507...80,531,005
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases phosphorylation
decreases response to substance
decreases expression
multiple interactions
increases expression
EXP Cadmium Chloride results in increased phosphorylation of HSPA5 protein
HSPA5 results in decreased susceptibility to Cadmium Chloride
Cadmium Chloride results in decreased expression of HSPA5 mRNA
Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 mRNA]; CAT inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 mRNA]; Cycloheximide inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 protein]; Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 protein]; SOD2 inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 mRNA]; SOD2 inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 protein]
Cadmium Chloride results in increased expression of HSPA5 mRNA; Cadmium Chloride results in increased expression of HSPA5 protein
CTD PMID:16759985 PMID:17464326 PMID:18086661 PMID:20576581 PMID:20600546 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
G HSPA6 heat shock protein family A (Hsp70) member 6 increases expression EXP Cadmium Chloride results in increased expression of HSP70 protein CTD PMID:16759985 NCBI chr 4:88,970,592...88,973,109
Ensembl chr 4:88,970,591...88,985,586
JBrowse link
G HYOU1 hypoxia up-regulated 1 decreases response to substance EXP HYOU1 results in decreased susceptibility to Cadmium Chloride CTD PMID:17464326 NCBI chr 9:46,264,929...46,277,056
Ensembl chr 9:46,264,929...46,276,996
JBrowse link
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 affects binding
decreases activity
multiple interactions
affects folding
decreases response to substance
EXP Cadmium Chloride binds to IDH2 protein
Cadmium Chloride results in decreased activity of IDH2 protein
[oxalomalic acid results in decreased activity of IDH2 protein] which results in increased susceptibility to Cadmium Chloride; Dithiothreitol inhibits the reaction [Cadmium Chloride results in decreased activity of IDH2 protein]; Glutathione inhibits the reaction [Cadmium Chloride results in decreased activity of IDH2 protein]; IDH2 protein inhibits the reaction [Cadmium Chloride results in decreased activity of GLRX protein]
Cadmium Chloride affects the folding of IDH2 protein
IDH2 protein results in decreased susceptibility to Cadmium Chloride
CTD PMID:16785314 NCBI chr 7:55,654,298...55,675,571
Ensembl chr 7:55,651,606...55,681,426
JBrowse link
G IFNG interferon gamma multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IFNG mRNA CTD PMID:33592257 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,848...32,482,752
JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IKBKB mRNA CTD PMID:33592257 NCBI chr17:11,289,607...11,348,557
Ensembl chr17:11,289,690...11,348,553
JBrowse link
G IL10 interleukin 10 multiple interactions
decreases expression
EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of IL10 mRNA
Cadmium Chloride results in decreased expression of IL10 mRNA
CTD PMID:33592257 PMID:33626375 NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,727...67,405,711
JBrowse link
G IL17A interleukin 17A multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL17A mRNA CTD PMID:33592257 NCBI chr 7:46,013,584...46,017,161
Ensembl chr 7:46,013,584...46,017,153
JBrowse link
G IL18 interleukin 18 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL18 mRNA CTD PMID:33592257 NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,966...39,873,300
JBrowse link
G IL1A interleukin 1 alpha multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL1A mRNA CTD PMID:33592257 NCBI chr 3:43,718,320...43,731,668
Ensembl chr 3:43,718,368...43,731,119
JBrowse link
G IL2 interleukin 2 multiple interactions
increases expression
EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL2 mRNA
Cadmium Chloride results in increased expression of IL2 mRNA
CTD PMID:33592257 PMID:33626375 NCBI chr 8:101,640,938...101,645,683
Ensembl chr 8:101,640,944...101,645,609
JBrowse link
G IL6 interleukin 6 multiple interactions
increases expression
EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL6 mRNA
Cadmium Chloride results in increased expression of IL6 mRNA
CTD PMID:33592257 PMID:33626375 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G IL7 interleukin 7 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL7 mRNA CTD PMID:33592257 NCBI chr 4:57,677,895...57,744,713
Ensembl chr 4:57,685,069...57,753,797
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP Cadmium Chloride results in increased expression of JUN mRNA CTD PMID:7564105 NCBI chr 6:153,686,425...153,687,635 JBrowse link
G LOC110258578 interleukin-1 beta-like multiple interactions
increases expression
EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL1B mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL1B protein
Cadmium Chloride results in increased expression of IL1B mRNA
CTD PMID:33592257 PMID:33626375
G LRP2 LDL receptor related protein 2 decreases expression
multiple interactions
increases degradation
EXP Cadmium Chloride results in decreased expression of LRP2 mRNA; Cadmium Chloride results in decreased expression of LRP2 protein
bafilomycin A inhibits the reaction [Cadmium Chloride results in decreased expression of LRP2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Cadmium Chloride results in decreased expression of LRP2 protein]; Cycloheximide promotes the reaction [Cadmium Chloride results in decreased expression of LRP2 protein]
Cadmium Chloride results in increased degradation of LRP2 protein
CTD PMID:20576581 NCBI chr15:75,565,299...75,754,604
Ensembl chr15:75,565,301...75,716,694
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
EXP 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]; Selenium inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]; XBP1 affects the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein] CTD PMID:10696784 PMID:17383151 PMID:17464326 PMID:18086661 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,172,200
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation
EXP 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK9 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK9 protein]; Selenium inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK9 protein] CTD PMID:10696784 PMID:17383151 NCBI chr 2:78,338,466...78,399,108
Ensembl chr 2:78,338,369...78,399,105
JBrowse link
G MFF mitochondrial fission factor multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MFF mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MFF protein CTD PMID:33493553 NCBI chr15:128,768,441...128,799,355
Ensembl chr15:128,768,348...128,799,345
JBrowse link
G MFN1 mitofusin 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of MFN1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of MFN1 protein CTD PMID:33493553 PMID:33592257 NCBI chr13:117,404,637...117,441,750
Ensembl chr13:117,404,699...117,442,481
JBrowse link
G MFN2 mitofusin 2 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of MFN2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of MFN2 protein CTD PMID:33493553 PMID:33592257 NCBI chr 6:72,026,512...72,056,439
Ensembl chr 6:72,026,722...72,056,439
JBrowse link
G MIR125A microRNA mir-125a decreases expression
multiple interactions
EXP Cadmium Chloride results in decreased expression of MIR125A mRNA
[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAK1 protein; [Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAX protein; [Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of CASP3 protein; [Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of CASP9 protein; Cadmium Chloride promotes the reaction [MIR125A mRNA mutant form results in decreased expression of BCL2 protein]; MIR125A mRNA inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein]; MIR125A mRNA inhibits the reaction [Cadmium Chloride results in increased expression of BAK1 protein]; MIR125A mRNA inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]; MIR125A mRNA inhibits the reaction [Cadmium Chloride results in increased expression of CASP3 protein]; MIR125A mRNA inhibits the reaction [Cadmium Chloride results in increased expression of CASP9 protein]; Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAK1 protein]; Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAX protein]; Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of CASP3 protein]; Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of CASP9 protein]; Sodium Selenite inhibits the reaction [Cadmium Chloride promotes the reaction [MIR125A mRNA mutant form results in decreased expression of BCL2 protein]]
CTD PMID:26607349 NCBI chr 6:58,331,566...58,331,645
Ensembl chr 6:58,331,566...58,331,645
JBrowse link
G MLKL mixed lineage kinase domain like pseudokinase increases expression EXP Cadmium Chloride results in increased expression of MLKL mRNA; Cadmium Chloride results in increased expression of MLKL protein CTD PMID:33626375 NCBI chr 6:12,923,846...12,951,176
Ensembl chr 6:12,924,894...12,951,173
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor increases expression EXP Cadmium Chloride results in increased expression of MYC mRNA CTD PMID:7564105 NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,119...12,461,078
JBrowse link
G NFE2 nuclear factor, erythroid 2 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of NFE2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of NFE2 protein CTD PMID:33592257 NCBI chr 5:19,494,672...19,501,810
Ensembl chr 5:19,494,677...19,501,810
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 decreases expression EXP Cadmium Chloride results in decreased expression of NFE2L2 mRNA; Cadmium Chloride results in decreased expression of NFE2L2 protein CTD PMID:33626375 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NFKB1 mRNA CTD PMID:33592257 NCBI chr 8:118,391,010...118,478,927
Ensembl chr 8:118,390,637...118,506,691
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NFKBIA mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of and results in increased ubiquitination of NFKBIA protein CTD PMID:33592257 NCBI chr 7:64,508,119...64,510,754
Ensembl chr 7:64,508,016...64,558,057
JBrowse link
G NKRF NFKB repressing factor increases expression EXP Cadmium Chloride results in increased expression of NKRF mRNA CTD PMID:33626375 NCBI chr  X:98,008,870...98,025,423
Ensembl chr  X:98,007,877...98,025,375
JBrowse link
G NLRP3 NLR family pyrin domain containing 3 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NLRP3 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NLRP3 protein CTD PMID:33592257 NCBI chr 2:56,892,241...56,977,412
Ensembl chr 2:56,892,242...56,977,234
JBrowse link
G NOS2 nitric oxide synthase 2 increases expression
multiple interactions
EXP Cadmium Chloride results in increased expression of NOS2 mRNA; Cadmium Chloride results in increased expression of NOS2 protein
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NOS2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NOS2 protein
CTD PMID:33592257 PMID:33626375 NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,944...44,327,111
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 decreases expression
multiple interactions
EXP Cadmium Chloride results in decreased expression of NQO1 mRNA
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of NQO1 mRNA
CTD PMID:33493553 PMID:33626375 NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,769...17,302,590
JBrowse link
G NRF1 nuclear respiratory factor 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of NRF1 mRNA CTD PMID:33592257 NCBI chr18:19,008,408...19,142,678
Ensembl chr18:18,998,905...19,142,628
JBrowse link
G OPA1 OPA1 mitochondrial dynamin like GTPase multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of OPA1 mRNA CTD PMID:33592257 NCBI chr13:130,624,771...130,718,345
Ensembl chr13:130,624,823...130,719,083
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions
increases cleavage
EXP GLRX protein inhibits the reaction [Cadmium Chloride results in increased cleavage of PARP1 protein]; oxalomalic acid promotes the reaction [Cadmium Chloride results in increased cleavage of PARP1 protein] CTD PMID:16785314 NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,159...14,241,197
JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PIK3CG mRNA CTD PMID:33493553 NCBI chr 9:106,698,200...106,748,217
Ensembl chr 9:106,698,207...106,745,099
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PPARGC1A mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PPARGC1A protein CTD PMID:33592257 NCBI chr 8:17,841,844...18,527,953
Ensembl chr 8:17,841,844...17,961,909
JBrowse link
G PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PRKAA1 mRNA CTD PMID:33592257 NCBI chr16:25,745,902...25,783,524
Ensembl chr16:25,745,321...25,783,610
JBrowse link
G PTGER3 prostaglandin E receptor 3 increases expression EXP Cadmium Chloride results in increased expression of PTGER3 mRNA CTD PMID:33626375 NCBI chr 6:141,958,955...142,160,437
Ensembl chr 6:141,958,954...142,161,292
JBrowse link
G PTGES3 prostaglandin E synthase 3 increases expression EXP Cadmium Chloride results in increased expression of PTGES3 protein CTD PMID:33626375 NCBI chr 5:22,000,335...22,022,830
Ensembl chr 5:22,000,339...22,021,663
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
EXP Cadmium Chloride results in increased expression of PTGS2 mRNA; Cadmium Chloride results in increased expression of PTGS2 protein
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PTGS2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PTGS2 protein
CTD PMID:33592257 PMID:33626375 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,013...127,858,884
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit affects localization EXP Cadmium Chloride affects the localization of RELA protein CTD PMID:23575899 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,471
JBrowse link
G RIPK1 receptor interacting serine/threonine kinase 1 increases expression EXP Cadmium Chloride results in increased expression of RIPK1 mRNA; Cadmium Chloride results in increased expression of RIPK1 protein CTD PMID:33626375 NCBI chr 7:1,841,143...1,880,705
Ensembl chr 7:1,841,236...1,880,699
JBrowse link
G RIPK3 receptor interacting serine/threonine kinase 3 increases expression EXP Cadmium Chloride results in increased expression of RIPK3 mRNA; Cadmium Chloride results in increased expression of RIPK3 protein CTD PMID:33626375 NCBI chr 7:74,951,145...74,955,255
Ensembl chr 7:74,951,060...74,955,192
JBrowse link
G SMAD2 SMAD family member 2 increases expression EXP Cadmium Chloride results in increased expression of SMAD2 mRNA CTD PMID:33626375 NCBI chr 1:97,415,360...97,511,388
Ensembl chr 1:97,415,716...97,511,358
JBrowse link
G SMAD3 SMAD family member 3 increases expression EXP Cadmium Chloride results in increased expression of SMAD3 mRNA CTD PMID:33626375 NCBI chr 1:164,998,457...165,124,455
Ensembl chr 1:164,998,083...165,124,454
JBrowse link
G SMAD4 SMAD family member 4 increases expression EXP Cadmium Chloride results in increased expression of SMAD4 mRNA CTD PMID:33626375 NCBI chr 1:100,521,843...100,633,501
Ensembl chr 1:100,514,791...100,628,029
JBrowse link
G SMAD7 SMAD family member 7 decreases expression EXP Cadmium Chloride results in decreased expression of SMAD7 mRNA; Cadmium Chloride results in decreased expression of SMAD7 protein CTD PMID:33626375 NCBI chr 1:98,512,800...98,543,924
Ensembl chr 1:98,510,229...98,542,382
JBrowse link
G SOD1 superoxide dismutase 1 decreases expression
multiple interactions
EXP Cadmium Chloride results in decreased expression of SOD1 mRNA
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SOD1 mRNA
CTD PMID:33493553 PMID:33626375 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,749
JBrowse link
G SOD2 superoxide dismutase 2 decreases response to substance
decreases expression
multiple interactions
EXP SOD2 results in decreased susceptibility to Cadmium Chloride
Cadmium Chloride results in decreased expression of SOD2 mRNA
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SOD2 mRNA; SOD2 inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 mRNA]; SOD2 inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 mRNA]; SOD2 inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 protein]; SOD2 inhibits the reaction [Cadmium Chloride results in increased splicing of XBP1 mRNA]
CTD PMID:18086661 PMID:33493553 PMID:33626375 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,651,280...7,691,723
JBrowse link
G TFAM transcription factor A, mitochondrial multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of TFAM mRNA CTD PMID:33592257 NCBI chr14:92,261,713...92,279,731
Ensembl chr14:92,259,403...92,279,550
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions
increases expression
EXP Cadmium Chloride results in increased expression of and results in increased cleavage of TGFB1 protein
Cadmium Chloride results in increased expression of TGFB1 mRNA; Cadmium Chloride results in increased expression of TGFB1 protein
CTD PMID:33626375 NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,169...49,349,048
JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 increases expression EXP Cadmium Chloride results in increased expression of TGFBR1 mRNA CTD PMID:33626375 NCBI chr 1:240,842,735...240,918,267
Ensembl chr 1:240,859,270...240,918,528
JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 increases expression EXP Cadmium Chloride results in increased expression of TGFBR2 mRNA CTD PMID:33626375 NCBI chr13:16,784,370...16,875,828
Ensembl chr13:16,784,491...16,878,165
JBrowse link
G TNF tumor necrosis factor increases expression EXP Cadmium Chloride results in increased expression of TNF mRNA; Cadmium Chloride results in increased expression of TNF protein CTD PMID:33626375 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A multiple interactions
increases expression
EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNFRSF1A mRNA
Cadmium Chloride results in increased expression of TNFRSF1A mRNA; Cadmium Chloride results in increased expression of TNFRSF1A protein
CTD PMID:33592257 PMID:33626375 NCBI chr 5:64,319,349...64,331,876
Ensembl chr 5:64,319,073...64,331,909
JBrowse link
G TRAF6 TNF receptor associated factor 6 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TRAF6 mRNA CTD PMID:33592257 NCBI chr 2:24,602,749...24,628,263
Ensembl chr 2:24,602,783...24,626,072
JBrowse link
G TWNK twinkle mtDNA helicase multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of TWNK mRNA CTD PMID:33592257 NCBI chr14:112,068,463...112,076,169
Ensembl chr14:112,066,846...112,075,822
JBrowse link
G XBP1 X-box binding protein 1 increases splicing
multiple interactions
EXP Cadmium Chloride results in increased splicing of XBP1 mRNA
SOD2 inhibits the reaction [Cadmium Chloride results in increased splicing of XBP1 mRNA]; XBP1 affects the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]
CTD PMID:17464326 PMID:18086661 NCBI chr14:46,011,239...46,016,526
Ensembl chr14:46,008,377...46,017,036
JBrowse link
mercury dichloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AQP1 aquaporin 1 (Colton blood group) multiple interactions EXP Mercuric Chloride inhibits the reaction [AQP1 protein results in increased transport of Water] CTD PMID:16534851 NCBI chr18:42,063,482...42,076,741
Ensembl chr18:42,063,481...42,076,746
JBrowse link
G ATF4 activating transcription factor 4 increases expression EXP Mercuric Chloride results in increased expression of ATF4 protein CTD PMID:16759985 NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,738,880...8,745,225
JBrowse link
G EIF2A eukaryotic translation initiation factor 2A increases phosphorylation EXP Mercuric Chloride results in increased phosphorylation of EIF2A protein CTD PMID:16759985 NCBI chr13:90,761,453...90,804,274
Ensembl chr13:90,761,465...90,804,276
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
EXP Dactinomycin inhibits the reaction [Mercuric Chloride results in increased expression of FOS mRNA]
Mercuric Chloride results in increased expression of FOS mRNA; Mercuric Chloride results in increased expression of FOS protein
CTD PMID:9463523 NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554
JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 increases expression EXP Mercuric Chloride results in increased expression of HSP90B1 mRNA CTD PMID:17464326 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,507...80,531,005
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Mercuric Chloride results in increased expression of HSPA5 mRNA CTD PMID:17464326 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit increases expression
increases phosphorylation
EXP Mercuric Chloride results in increased expression of JUN mRNA; Mercuric Chloride results in increased expression of JUN protein
Mercuric Chloride results in increased phosphorylation of JUN protein
CTD PMID:10696784 NCBI chr 6:153,686,425...153,687,635 JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases phosphorylation EXP Mercuric Chloride results in increased phosphorylation of MAPK8 protein CTD PMID:10696784 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,172,200
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 increases phosphorylation EXP Mercuric Chloride results in increased phosphorylation of MAPK9 protein CTD PMID:10696784 NCBI chr 2:78,338,466...78,399,108
Ensembl chr 2:78,338,369...78,399,105
JBrowse link
zinc protoporphyrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 multiple interactions EXP zinc protoporphyrin inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1B1 protein] CTD PMID:19466990 NCBI chr 8:44,544,364...44,604,690
Ensembl chr 8:44,544,179...44,604,704
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 908
    chemical entity 908
      molecular entity 906
        polyatomic entity 875
          heteroatomic molecular entity 832
            coordination entity 119
              zinc group coordination entity 94
                cadmium coordination entity + 93
                mercury coordination entity + 9
                zinc coordination entity + 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 908
    subatomic particle 893
      composite particle 893
        hadron 893
          baryon 893
            nucleon 893
              atomic nucleus 893
                atom 893
                  metal atom 201
                    transition element atom 161
                      d-block element atom 161
                        zinc group element atom 130
                          zinc group molecular entity 128
                            zinc group coordination entity 94
                              cadmium coordination entity + 93
                              mercury coordination entity + 9
                              zinc coordination entity + 1
paths to the root