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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:zinc oxide
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Accession:CHEBI:36560 term browser browse the term
Definition:A zinc molecular entity that has formula OZn.
Synonyms:related_synonym: Formula=OZn;   InChI=1S/O.Zn;   InChIKey=XLOMVQKBTHCTTD-UHFFFAOYSA-N;   SMILES=O=[Zn];   Zinkoxid;   ZnO;   oxido de cinc;   oxyde de zinc
 alt_id: CHEBI:30186;   CHEBI:32311
 xref: CAS:1314-13-2;   Drug_Central:4240;   Gmelin:13738;   KEGG:D01170
 xref_mesh: MESH:D015034
 xref: PPDB:1321;   Wikipedia:Zinc_Oxide


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zinc oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 decreases expression ISO Zinc Oxide analog results in decreased expression of ADRB1 mRNA CTD PMID:27185063 NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259
JBrowse link
G Adrb3 adrenoceptor beta 3 decreases expression ISO Zinc Oxide analog results in decreased expression of ADRB3 mRNA CTD PMID:27185063 NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552
JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases expression ISO Zinc Oxide analog results in decreased expression of AGTR1 mRNA CTD PMID:27185063 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO homoorientin promotes the reaction [Zinc Oxide analog results in decreased phosphorylation of AKT1 protein]; Zinc Oxide analog promotes the reaction [homoorientin results in decreased phosphorylation of AKT1 protein]
[Zinc Oxide results in increased abundance of Zinc] which results in increased phosphorylation of AKT1 protein
CTD PMID:24374571 PMID:24614525 PMID:28115650 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alb albumin increases secretion
multiple interactions
affects binding
increases response to substance
ISO
EXP
Zinc Oxide results in increased secretion of ALB protein
ALB protein promotes the reaction [Zinc Oxide binds to Dimethoate]
Zinc Oxide binds to ALB protein
ALB protein results in increased susceptibility to Zinc Oxide
[cupric oxide co-treated with lead oxide co-treated with Zinc Oxide] results in decreased expression of ALB protein
CTD PMID:23726862 PMID:27441385 PMID:28212817 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 multiple interactions ISO Zinc Oxide affects the splicing of and results in increased expression of ALDH3A1 mRNA CTD PMID:30500950 NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions ISO Zinc Oxide affects the splicing of and results in increased expression of APAF1 mRNA CTD PMID:30500950 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
JBrowse link
G Ar androgen receptor increases expression ISO Zinc Oxide results in increased expression of AR mRNA CTD PMID:22083529 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Atg10 autophagy related 10 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased expression of ATG10 mRNA] CTD PMID:24614525 NCBI chr 2:22,109,304...22,398,313
Ensembl chr 2:22,108,426...22,398,233
JBrowse link
G Atg12 autophagy related 12 increases expression
multiple interactions
ISO Zinc Oxide analog results in increased expression of ATG12 mRNA
Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased expression of ATG12 mRNA]
CTD PMID:24614525 NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
JBrowse link
G Atg5 autophagy related 5 increases expression
multiple interactions
ISO Zinc Oxide analog results in increased expression of ATG5 mRNA
Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased expression of ATG5 mRNA]
CTD PMID:24614525 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 decreases expression ISO Zinc Oxide analog results in decreased expression of ATP2A2 mRNA CTD PMID:27185063 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
JBrowse link
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 decreases expression ISO Zinc Oxide analog results in decreased expression of ATP2B1 mRNA; Zinc Oxide analog results in decreased expression of ATP2B1 protein CTD PMID:24060544 NCBI chr 7:33,735,595...33,845,226
Ensembl chr 7:33,735,871...33,843,295
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO Zinc Oxide analog results in increased expression of BAX mRNA; Zinc Oxide analog results in increased expression of BAX protein
Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased expression of BAX protein]
CTD PMID:24614525 PMID:25680694 PMID:27544635 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bche butyrylcholinesterase decreases activity ISO Zinc Oxide results in decreased activity of BCHE protein CTD PMID:27441385 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO Zinc Oxide analog results in decreased expression of BCL2 mRNA; Zinc Oxide analog results in decreased expression of BCL2 protein
Thioctic Acid inhibits the reaction [Zinc Oxide analog results in decreased expression of BCL2 protein]
CTD PMID:24614525 PMID:25680694 PMID:27544635 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased expression of BECN1 protein] CTD PMID:24614525 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO Zinc Oxide affects the splicing of and affects the expression of BID mRNA CTD PMID:30500950 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression ISO Zinc Oxide results in increased expression of BNIP3 mRNA CTD PMID:19755143 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
JBrowse link
G Casp1 caspase 1 increases cleavage
multiple interactions
ISO Zinc Oxide analog results in increased cleavage of CASP1 protein
Zinc Oxide analog promotes the reaction [OVAL protein results in increased cleavage of CASP1 protein]
CTD PMID:25127755 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp12 caspase 12 increases expression
increases activity
EXP
ISO
Zinc Oxide results in increased expression of CASP12 mRNA
Zinc Oxide analog results in increased activity of CASP12 protein
CTD PMID:23232460 PMID:25680694 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases cleavage
ISO Zinc Oxide analog results in increased activity of CASP3 protein; Zinc Oxide results in increased activity of CASP3 protein
benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Zinc Oxide analog results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [Zinc Oxide analog results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP3 protein]
Zinc Oxide analog results in increased cleavage of CASP3 protein
Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased cleavage of CASP3 protein]; MAP1LC3B mutant form inhibits the reaction [Zinc Oxide analog results in increased cleavage of CASP3 protein]; Zinc Oxide affects the splicing of and results in increased expression of CASP3 mRNA
CTD PMID:22112499 PMID:24614525 PMID:25680694 PMID:27544635 PMID:30500950 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
increases cleavage
ISO Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased cleavage of CASP8 protein]
Zinc Oxide analog results in increased activity of CASP8 protein
benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Zinc Oxide analog results in increased activity of CASP8 protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP8 protein]
CTD PMID:24614525 PMID:27544635 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases cleavage
increases activity
multiple interactions
ISO Zinc Oxide analog results in increased cleavage of CASP9 protein
Zinc Oxide analog results in increased activity of CASP9 protein
benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Zinc Oxide analog results in increased activity of CASP9 protein]; Cyclosporine inhibits the reaction [Zinc Oxide analog results in increased activity of CASP9 protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP9 protein]
Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased cleavage of CASP9 protein]
CTD PMID:24614525 PMID:25680694 PMID:27544635 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase decreases expression
multiple interactions
decreases activity
ISO
EXP
Zinc Oxide results in decreased expression of CAT mRNA; Zinc Oxide results in decreased expression of CAT protein
Zinc Oxide promotes the reaction [Lipopolysaccharides results in decreased activity of CAT protein]
Quercetin inhibits the reaction [Zinc Oxide analog results in decreased activity of CAT protein]
CTD PMID:19382294 PMID:24614525 PMID:27111109 PMID:31804693 PMID:32600046 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
increases secretion
multiple interactions
ISO Zinc Oxide analog results in increased expression of CCL2 mRNA; Zinc Oxide analog results in increased expression of CCL2 protein
Zinc Oxide analog results in increased secretion of CCL2 protein
MYD88 mutant form inhibits the reaction [Zinc Oxide analog results in increased expression of CCL2 mRNA]; Zinc Oxide promotes the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]
CTD PMID:20851137 PMID:23352990 PMID:24746987 PMID:31804693 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cd36 CD36 molecule multiple interactions ISO [Zinc Oxide analog co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD36 protein CTD PMID:24746987 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Cd63 Cd63 molecule increases expression ISO Zinc Oxide results in increased expression of CD63 protein CTD PMID:23726862 NCBI chr 7:1,325,108...1,340,447
Ensembl chr 7:1,325,103...1,399,178
JBrowse link
G Cdc42 cell division cycle 42 multiple interactions ISO [RAC1 protein binds to CDC42 protein] affects the reaction [Zinc Oxide results in increased expression of ICAM1 protein]; NSC 23766 inhibits the reaction [Zinc Oxide results in increased activity of and results in increased phosphorylation of [RAC1 protein binds to CDC42 protein]]; Zinc Oxide results in increased activity of and results in increased phosphorylation of [RAC1 protein binds to CDC42 protein] CTD PMID:22166487 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Zinc Oxide analog results in increased expression of CDKN1A protein CTD PMID:24614525 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 multiple interactions ISO Zinc Oxide promotes the reaction [Carbachol inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]] CTD PMID:20708676 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278
JBrowse link
G Creb5 cAMP responsive element binding protein 5 decreases expression ISO Zinc Oxide analog results in decreased expression of CREB5 mRNA CTD PMID:27185063 NCBI chr 4:82,393,091...82,794,320
Ensembl chr 4:82,393,730...82,790,325
JBrowse link
G Crym crystallin, mu decreases expression ISO Zinc Oxide analog results in decreased expression of CRYM mRNA CTD PMID:27185063 NCBI chr 1:174,560,423...174,575,660
Ensembl chr 1:174,560,416...174,575,633
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Zinc Oxide promotes the reaction [Lipopolysaccharides results in increased secretion of CSF2 protein] CTD PMID:31804693 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression
multiple interactions
ISO Zinc Oxide analog results in increased expression of CXCL1 mRNA
MYD88 mutant form inhibits the reaction [Zinc Oxide analog results in increased expression of CXCL1 mRNA]
CTD PMID:23352990 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 increases expression ISO Zinc Oxide results in increased expression of CXCL9 CTD PMID:19897006 NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435
JBrowse link
G Dazl deleted in azoospermia-like increases expression ISO Zinc Oxide results in increased expression of DAZL mRNA CTD PMID:33098963 NCBI chr 9:10,695,572...10,712,443
Ensembl chr 9:10,695,592...10,712,323
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Zinc Oxide analog results in increased expression of DDIT3 mRNA; Zinc Oxide analog results in increased expression of DDIT3 protein CTD PMID:25680694 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Ddx4 DEAD-box helicase 4 increases expression ISO Zinc Oxide results in increased expression of DDX4 mRNA CTD PMID:33098963 NCBI chr 2:44,227,946...44,282,867
Ensembl chr 2:44,227,946...44,282,723
JBrowse link
G Dhcr7 7-dehydrocholesterol reductase multiple interactions ISO Zinc Oxide affects the splicing of and results in increased expression of DHCR7 mRNA CTD PMID:30500950 NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
JBrowse link
G Dnaja4 DnaJ heat shock protein family (Hsp40) member A4 increases expression ISO Zinc Oxide results in increased expression of DNAJA4 protein CTD PMID:21769377 NCBI chr 8:55,085,246...55,102,715
Ensembl chr 8:55,085,464...55,101,207
JBrowse link
G Dppa3 developmental pluripotency-associated 3 increases expression ISO Zinc Oxide results in increased expression of DPPA3 mRNA CTD PMID:33098963 NCBI chr 4:155,851,461...155,854,845
Ensembl chr 4:155,815,296...155,854,861
JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase multiple interactions ISO Zinc Oxide affects the splicing of and results in increased expression of EHHADH mRNA CTD PMID:30500950 NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation ISO Zinc Oxide analog results in increased phosphorylation of EIF2AK3 protein CTD PMID:25680694 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO Zinc Oxide analog results in increased phosphorylation of EIF2S1 protein CTD PMID:25680694 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Fas Fas cell surface death receptor multiple interactions
decreases expression
increases expression
ISO benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Zinc Oxide analog results in increased expression of FAS protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased expression of FAS protein]
Zinc Oxide results in decreased expression of FAS mRNA
Zinc Oxide affects the splicing of and results in increased expression of FAS mRNA
CTD PMID:27544635 PMID:30500950 PMID:32600046 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Zinc Oxide results in increased expression of FOS protein CTD PMID:24368203 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta increases expression ISO Zinc Oxide results in increased expression of GADD45B protein CTD PMID:21769377 NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO Zinc Oxide affects the splicing of and results in increased expression of GCLC mRNA CTD PMID:30500950 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO Zinc Oxide affects the splicing of and results in increased expression of GCLM mRNA CTD PMID:30500950 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions EXP [cupric oxide co-treated with lead oxide co-treated with Zinc Oxide] results in increased activity of GGT1 protein; [lead oxide co-treated with Zinc Oxide] results in increased activity of GGT1 protein CTD PMID:28212817 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression
multiple interactions
ISO
EXP
Zinc Oxide analog results in increased expression of GPT protein
Zinc Oxide inhibits the reaction [Dimethylnitrosamine results in increased uptake of GPT protein]
CTD PMID:25680694 PMID:29024620 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity
multiple interactions
ISO Zinc Oxide analog results in decreased activity of GSR protein
Zinc Oxide affects the splicing of and affects the expression of GSR mRNA
CTD PMID:24614525 PMID:30500950 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gss glutathione synthetase multiple interactions ISO Zinc Oxide affects the splicing of and results in increased expression of GSS mRNA CTD PMID:30500950 NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198
JBrowse link
G H2ax H2A.X variant histone increases activity
multiple interactions
ISO Zinc Oxide analog results in increased activity of H2AX protein
Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased activity of H2AX protein]
CTD PMID:24614525 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
EXP
ISO
Zinc Oxide results in increased expression of HMOX1 mRNA; Zinc Oxide results in increased expression of HMOX1 protein
Zinc Oxide affects the splicing of and results in increased expression of HMOX1 mRNA
CTD PMID:21769377 PMID:22640810 PMID:29289694 PMID:30500950 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 multiple interactions
decreases expression
EXP Quercetin inhibits the reaction [Zinc Oxide analog results in decreased expression of HSD17B3 mRNA] CTD PMID:27111109 NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 increases expression ISO Zinc Oxide analog results in increased expression of HSP90B1 mRNA CTD PMID:25680694 NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO Zinc Oxide results in increased expression of HSPA1A protein CTD PMID:21769377
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Zinc Oxide analog results in increased expression of HSPA5 mRNA CTD PMID:25680694 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
increases expression
ISO [RAC1 protein binds to CDC42 protein] affects the reaction [Zinc Oxide results in increased expression of ICAM1 protein]; BAY 11-7085 inhibits the reaction [Zinc Oxide results in increased expression of ICAM1]; JUN protein affects the reaction [Zinc Oxide results in increased expression of ICAM1 protein]; NSC 23766 inhibits the reaction [Zinc Oxide results in increased expression of ICAM1]; pyrazolanthrone inhibits the reaction [Zinc Oxide results in increased expression of ICAM1]
Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of ICAM1 protein]
Zinc Oxide analog results in increased expression of ICAM1 protein; Zinc Oxide results in increased expression of ICAM1 protein
Zinc Oxide analog results in increased expression of ICAM1 protein; Zinc Oxide results in increased expression of ICAM1 mRNA; Zinc Oxide results in increased expression of ICAM1 protein
CTD PMID:22166487 PMID:24746987 PMID:25127755 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma increases expression
multiple interactions
ISO Zinc Oxide results in increased expression of IFNG protein
Zinc Oxide affects the splicing of and results in increased expression of IFNG mRNA
CTD PMID:24368203 PMID:30500950 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 increases expression ISO Zinc Oxide analog results in increased expression of IL10 protein; Zinc Oxide results in increased expression of IL10 protein CTD PMID:20851137 PMID:24368203 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il12b interleukin 12B multiple interactions EXP Zinc Oxide inhibits the reaction [Dimethylnitrosamine results in increased expression of IL12B protein] CTD PMID:29024620 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
ISO Zinc Oxide results in increased expression of IL1B
[Zinc Oxide analog co-treated with OVAL protein] results in increased expression of IL1B protein; Zinc Oxide promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
Zinc Oxide analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
CTD PMID:19897006 PMID:24631018 PMID:25127755 PMID:31804693 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 increases secretion
increases expression
multiple interactions
EXP
ISO
Zinc Oxide results in increased secretion of IL6 protein
Zinc Oxide analog results in increased expression of IL6 protein
Zinc Oxide analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
Zinc Oxide analog results in increased expression of IL6 mRNA; Zinc Oxide results in increased expression of IL6 protein
MYD88 mutant form inhibits the reaction [Zinc Oxide analog results in increased expression of IL6 mRNA]; Zinc Oxide affects the splicing of and results in increased expression of IL6 mRNA; Zinc Oxide promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
CTD PMID:17301066 PMID:23352990 PMID:24368203 PMID:24631018 PMID:27185063 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO [Zinc Oxide analog co-treated with OVAL protein] results in increased expression of IRAK1 protein CTD PMID:25127755 NCBI chr  X:151,768,621...151,778,521
Ensembl chr  X:151,768,777...151,778,521
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
affects localization
ISO JUN protein affects the reaction [Zinc Oxide results in increased expression of ICAM1 protein]; NSC 23766 inhibits the reaction [Zinc Oxide results in increased phosphorylation of and results in increased activity of JUN protein]; pyrazolanthrone inhibits the reaction [Zinc Oxide affects the localization of JUN protein]; pyrazolanthrone inhibits the reaction [Zinc Oxide results in increased phosphorylation of and results in increased activity of JUN protein]; Zinc Oxide results in increased phosphorylation of and results in increased activity of JUN protein
Zinc Oxide results in increased expression of JUN protein
CTD PMID:22166487 PMID:24368203 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 increases expression ISO Zinc Oxide results in increased expression of LAMP2 protein CTD PMID:29289694 NCBI chr  X:117,173,097...117,222,090
Ensembl chr  X:117,057,606...117,260,522
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase multiple interactions ISO Zinc Oxide analog promotes the reaction [OVAL protein results in increased phosphorylation of LYN protein] CTD PMID:25127755 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression
ISO MAP1LC3B mutant form inhibits the reaction [Zinc Oxide analog results in increased cleavage of CASP3 protein]
Zinc Oxide results in increased expression of MAP1LC3B protein
CTD PMID:24614525 PMID:29289694 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Map3k11 mitogen-activated protein kinase kinase kinase 11 multiple interactions
increases expression
ISO NSC 23766 inhibits the reaction [Zinc Oxide results in increased expression of MAP3K11 protein] CTD PMID:22166487 NCBI chr 1:202,975,353...202,988,655
Ensembl chr 1:202,975,353...202,988,652
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO homoorientin promotes the reaction [Zinc Oxide analog results in decreased phosphorylation of MAPK1 protein]; Zinc Oxide analog promotes the reaction [homoorientin results in decreased phosphorylation of MAPK1 protein]
[Zinc Oxide results in increased abundance of Zinc] which results in increased phosphorylation of MAPK1 protein
CTD PMID:24374571 PMID:28115650 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO homoorientin promotes the reaction [Zinc Oxide analog results in decreased phosphorylation of MAPK3 protein]; Zinc Oxide analog promotes the reaction [homoorientin results in decreased phosphorylation of MAPK3 protein]
[Zinc Oxide results in increased abundance of Zinc] which results in increased phosphorylation of MAPK3 protein
CTD PMID:24374571 PMID:28115650 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp13 matrix metallopeptidase 13 decreases expression ISO Zinc Oxide analog results in decreased expression of MMP13 mRNA CTD PMID:27185063 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases secretion
multiple interactions
increases activity
ISO Zinc Oxide results in increased secretion of MMP9 protein
Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of MMP9 protein]
Zinc Oxide results in increased activity of MMP9 protein
CTD PMID:23726862 PMID:25127755 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase increases secretion ISO Zinc Oxide results in increased secretion of MPO protein CTD PMID:23726862 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Msr1 macrophage scavenger receptor 1 multiple interactions ISO [Zinc Oxide analog co-treated with Tetradecanoylphorbol Acetate] results in increased expression of MSR1 protein CTD PMID:24746987 NCBI chr16:52,717,775...52,802,890
Ensembl chr16:52,717,732...52,799,676
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO Zinc Oxide analog results in decreased phosphorylation of MTOR protein CTD PMID:24614525 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO MYD88 mutant form inhibits the reaction [Zinc Oxide analog results in increased expression of CCL2 mRNA]; MYD88 mutant form inhibits the reaction [Zinc Oxide analog results in increased expression of CXCL1 mRNA]; MYD88 mutant form inhibits the reaction [Zinc Oxide analog results in increased expression of IL6 mRNA]; MYD88 mutant form inhibits the reaction [Zinc Oxide analog results in increased expression of TNF mRNA]; Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of MYD88 protein] CTD PMID:23352990 PMID:25127755 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases expression ISO Zinc Oxide analog results in decreased expression of NFE2L2 protein CTD PMID:24614525 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Zinc Oxide affects the splicing of and results in increased expression of NFKB1 mRNA CTD PMID:30500950 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 multiple interactions ISO Zinc Oxide affects the splicing of and results in decreased expression of NFKB2 mRNA CTD PMID:30500950 NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Zinc Oxide results in increased phosphorylation of and results in increased degradation of NFKBIA protein CTD PMID:20194077 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nobox NOBOX oogenesis homeobox decreases expression ISO Zinc Oxide results in decreased expression of NOBOX mRNA CTD PMID:33098963 NCBI chr 4:72,128,931...72,134,436
Ensembl chr 4:72,128,931...72,134,436
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO Zinc Oxide results in increased expression of NOS2 protein CTD PMID:24368203 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO Zinc Oxide affects the splicing of and results in increased expression of NQO1 mRNA CTD PMID:30500950 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases expression ISO Zinc Oxide analog results in decreased expression of NR3C1 mRNA CTD PMID:27185063 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 multiple interactions
decreases expression
EXP Quercetin inhibits the reaction [Zinc Oxide analog results in decreased expression of NR5A1 mRNA] CTD PMID:27111109 NCBI chr 3:22,464,786...22,486,328
Ensembl chr 3:22,465,502...22,486,328
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased cleavage of PARP1 protein] CTD PMID:24614525 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 increases expression ISO Zinc Oxide analog results in increased expression of PDIA3 mRNA CTD PMID:25680694 NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236
JBrowse link
G Prdm1 PR/SET domain 1 increases expression ISO Zinc Oxide results in increased expression of PRDM1 mRNA CTD PMID:33098963 NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488
JBrowse link
G Prdx3 peroxiredoxin 3 increases expression ISO Zinc Oxide results in increased expression of PRDX3 mRNA CTD PMID:19755143 NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111
JBrowse link
G Prnp prion protein increases expression ISO Zinc Oxide results in increased expression of PRNP mRNA CTD PMID:19755143 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO Zinc Oxide affects the splicing of and results in increased expression of PTGS1 mRNA CTD PMID:30500950 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO Zinc Oxide analog results in increased expression of PTGS2 protein; Zinc Oxide results in increased expression of PTGS2 protein
Zinc Oxide affects the splicing of and affects the expression of PTGS2 mRNA; Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of PTGS2 protein]
CTD PMID:24368203 PMID:25127755 PMID:30500950 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO [RAC1 protein binds to CDC42 protein] affects the reaction [Zinc Oxide results in increased expression of ICAM1 protein]; NSC 23766 inhibits the reaction [Zinc Oxide results in increased activity of and results in increased phosphorylation of [RAC1 protein binds to CDC42 protein]]; Zinc Oxide results in increased activity of and results in increased phosphorylation of [RAC1 protein binds to CDC42 protein] CTD PMID:22166487 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link
G Rad51 RAD51 recombinase multiple interactions ISO Zinc Oxide affects the splicing of and results in increased expression of RAD51 mRNA CTD PMID:30500950 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases phosphorylation
multiple interactions
ISO Zinc Oxide results in increased phosphorylation of RELA protein
[Zinc Oxide results in increased phosphorylation of RELA protein] promotes the reaction [RELA protein binds to CXCL8 promoter]; Zinc Oxide promotes the reaction [RELA protein binds to CXCL8 promoter]
CTD PMID:20194077 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 increases expression ISO Zinc Oxide results in increased expression of RIPK1 mRNA CTD PMID:32600046 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 multiple interactions ISO Zinc Oxide affects the splicing of and results in increased expression of RIPK2 mRNA CTD PMID:30500950 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657
JBrowse link
G Slc11a2 solute carrier family 11 member 2 multiple interactions ISO Zinc Oxide affects the splicing of and results in decreased expression of SLC11A2 mRNA CTD PMID:30500950 NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145
JBrowse link
G Slc12a1 solute carrier family 12 member 1 decreases expression ISO Zinc Oxide analog results in decreased expression of SLC12A1 mRNA CTD PMID:27185063 NCBI chr 3:112,406,140...112,482,913
Ensembl chr 3:112,406,140...112,482,899
JBrowse link
G Slc30a1 solute carrier family 30 member 1 increases expression ISO Zinc Oxide results in increased expression of SLC30A1 mRNA CTD PMID:29289694 NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910
JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO Zinc Oxide results in increased expression of SOD1 mRNA CTD PMID:32600046 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO Zinc Oxide results in increased expression of SOD2 mRNA CTD PMID:32600046 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO Zinc Oxide results in increased expression of SQSTM1 protein CTD PMID:29289694 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Srxn1 sulfiredoxin 1 multiple interactions ISO Zinc Oxide affects the splicing of and results in increased expression of SRXN1 mRNA CTD PMID:30500950 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression ISO Zinc Oxide analog results in decreased expression of STAT1 mRNA CTD PMID:27185063 NCBI chr 9:49,419,561...49,459,969 JBrowse link
G Stra8 stimulated by retinoic acid 8 decreases expression ISO Zinc Oxide results in decreased expression of STRA8 mRNA CTD PMID:33098963 NCBI chr 4:63,601,443...63,624,777
Ensembl chr 4:63,601,604...63,624,771
JBrowse link
G Syk spleen associated tyrosine kinase multiple interactions ISO [Zinc Oxide analog co-treated with OVAL protein] results in increased phosphorylation of SYK protein CTD PMID:25127755 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410
JBrowse link
G Tert telomerase reverse transcriptase increases expression ISO Zinc Oxide results in increased expression of TERT mRNA CTD PMID:33098963 NCBI chr 1:29,637,213...29,659,509
Ensembl chr 1:29,637,506...29,659,561
JBrowse link
G Tlr1 toll-like receptor 1 multiple interactions ISO Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of TLR1 mRNA] CTD PMID:25127755 NCBI chr14:43,384,127...43,396,765
Ensembl chr14:43,384,932...43,397,125
JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO [Zinc Oxide analog co-treated with OVAL protein] results in increased expression of TLR2 protein; Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of TLR2 mRNA] CTD PMID:25127755 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO [Zinc Oxide analog co-treated with OVAL protein] results in increased expression of TLR4 protein; Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of TLR4 mRNA] CTD PMID:25127755 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tlr6 toll-like receptor 6 multiple interactions
increases expression
ISO [Zinc Oxide analog co-treated with OVAL protein] results in increased expression of TLR6 protein; Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of TLR6 mRNA]
Zinc Oxide analog results in increased expression of TLR6 mRNA
CTD PMID:25127755 NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO
EXP
Zinc Oxide analog results in increased expression of TNF mRNA; Zinc Oxide results in increased expression of TNF protein
Zinc Oxide inhibits the reaction [Dimethylnitrosamine results in increased expression of TNF protein]
MYD88 mutant form inhibits the reaction [Zinc Oxide analog results in increased expression of TNF mRNA]
CTD PMID:23352990 PMID:24368203 PMID:29024620 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO Zinc Oxide results in increased phosphorylation of and results in increased expression of TP53 protein
Zinc Oxide analog results in increased expression of TRP53 protein
CTD PMID:21903158 PMID:24614525 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO [Zinc Oxide analog co-treated with OVAL protein] results in increased expression of TRAF6 protein; Zinc Oxide affects the splicing of and results in increased expression of TRAF6 mRNA CTD PMID:25127755 PMID:30500950 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression
multiple interactions
ISO Zinc Oxide results in increased expression of TXNRD1 mRNA
Zinc Oxide affects the splicing of and affects the expression of TXNRD1 mRNA
CTD PMID:19755143 PMID:30500950 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Xbp1 X-box binding protein 1 increases expression ISO Zinc Oxide analog results in increased expression of XBP1 mRNA CTD PMID:25680694 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link
G Zfp36 zinc finger protein 36 increases expression ISO Zinc Oxide results in increased expression of ZFP36 protein CTD PMID:21769377 NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    chemical entity 19821
      molecular entity 19819
        transition element molecular entity 16555
          d-block molecular entity 16548
            zinc group molecular entity 10668
              zinc molecular entity 2776
                zinc oxide 122
                  zinc oxide nanoparticle 0
                  zinc oxide nanorod 0
                  zinc oxide nanotube 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  metal atom 17360
                    transition element atom 16852
                      d-block element atom 16843
                        zinc group element atom 11131
                          zinc atom 2776
                            zinc molecular entity 2776
                              zinc oxide 122
                                zinc oxide nanoparticle 0
                                zinc oxide nanorod 0
                                zinc oxide nanotube 0
paths to the root