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G |
Ache |
acetylcholinesterase |
increases expression |
ISO |
Zinc Oxide results in increased expression of ACHE protein |
CTD |
PMID:33247493 |
|
NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Adrb1 |
adrenoceptor beta 1 |
decreases expression |
ISO |
Zinc Oxide analog results in decreased expression of ADRB1 mRNA |
CTD |
PMID:27185063 |
|
NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259
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G |
Adrb3 |
adrenoceptor beta 3 |
decreases expression |
ISO |
Zinc Oxide analog results in decreased expression of ADRB3 mRNA |
CTD |
PMID:27185063 |
|
NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552
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G |
Agtr1a |
angiotensin II receptor, type 1a |
decreases expression |
ISO |
Zinc Oxide analog results in decreased expression of AGTR1 mRNA |
CTD |
PMID:27185063 |
|
NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions decreases phosphorylation |
ISO |
homoorientin promotes the reaction [Zinc Oxide analog results in decreased phosphorylation of AKT1 protein]; Zinc Oxide analog promotes the reaction [homoorientin results in decreased phosphorylation of AKT1 protein] [Zinc Oxide results in increased abundance of Zinc] which results in increased phosphorylation of AKT1 protein |
CTD |
PMID:24374571 PMID:24614525 PMID:28115650 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Alb |
albumin |
increases secretion multiple interactions increases response to substance affects binding |
ISO EXP |
Zinc Oxide results in increased secretion of ALB protein [cupric oxide co-treated with lead oxide co-treated with Zinc Oxide] results in decreased expression of ALB protein ALB protein results in increased susceptibility to Zinc Oxide Zinc Oxide binds to ALB protein ALB protein promotes the reaction [Zinc Oxide binds to Dimethoate] |
CTD |
PMID:23726862 PMID:27441385 PMID:28212817 |
|
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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G |
Aldh3a1 |
aldehyde dehydrogenase 3 family, member A1 |
multiple interactions |
ISO |
Zinc Oxide affects the splicing of and results in increased expression of ALDH3A1 mRNA |
CTD |
PMID:30500950 |
|
NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681
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G |
Apaf1 |
apoptotic peptidase activating factor 1 |
multiple interactions |
ISO |
Zinc Oxide affects the splicing of and results in increased expression of APAF1 mRNA |
CTD |
PMID:30500950 |
|
NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
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G |
Ar |
androgen receptor |
increases expression |
ISO |
Zinc Oxide results in increased expression of AR mRNA |
CTD |
PMID:22083529 |
|
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Atg10 |
autophagy related 10 |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased expression of ATG10 mRNA] |
CTD |
PMID:24614525 |
|
NCBI chr 2:22,109,304...22,398,313
Ensembl chr 2:22,108,426...22,398,233
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G |
Atg12 |
autophagy related 12 |
increases expression multiple interactions |
ISO |
Zinc Oxide analog results in increased expression of ATG12 mRNA Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased expression of ATG12 mRNA] |
CTD |
PMID:24614525 |
|
NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
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G |
Atg5 |
autophagy related 5 |
increases expression multiple interactions |
ISO EXP |
Zinc Oxide analog results in increased expression of ATG5 mRNA Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased expression of ATG5 mRNA] Zinc Oxide results in increased expression of ATG5 mRNA |
CTD |
PMID:24614525 PMID:32951350 |
|
NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209
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G |
Atg7 |
autophagy related 7 |
increases expression |
EXP |
Zinc Oxide results in increased expression of ATG7 mRNA |
CTD |
PMID:32951350 |
|
NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
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G |
Atp2a2 |
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 |
decreases expression |
ISO |
Zinc Oxide analog results in decreased expression of ATP2A2 mRNA |
CTD |
PMID:27185063 |
|
NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
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G |
Atp2b1 |
ATPase plasma membrane Ca2+ transporting 1 |
decreases expression |
ISO |
Zinc Oxide analog results in decreased expression of ATP2B1 mRNA; Zinc Oxide analog results in decreased expression of ATP2B1 protein |
CTD |
PMID:24060544 |
|
NCBI chr 7:33,735,595...33,845,226
Ensembl chr 7:33,735,871...33,843,295
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions affects expression |
ISO EXP |
Zinc Oxide analog results in increased expression of BAX mRNA; Zinc Oxide analog results in increased expression of BAX protein; Zinc Oxide results in increased expression of BAX mRNA Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased expression of BAX protein] lead acetate promotes the reaction [Zinc Oxide results in increased expression of BAX mRNA]; Zinc Oxide promotes the reaction [lead acetate results in increased expression of BAX mRNA] Zinc Oxide affects the expression of BAX mRNA |
CTD |
PMID:24614525 PMID:25680694 PMID:27544635 PMID:33236829 PMID:33599401 PMID:34553816 More...
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|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bche |
butyrylcholinesterase |
decreases activity |
ISO |
Zinc Oxide results in decreased activity of BCHE protein |
CTD |
PMID:27441385 |
|
NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions increases expression |
ISO EXP |
Zinc Oxide analog results in decreased expression of BCL2 mRNA; Zinc Oxide analog results in decreased expression of BCL2 protein; Zinc Oxide results in decreased expression of BCL2 mRNA Thioctic Acid inhibits the reaction [Zinc Oxide analog results in decreased expression of BCL2 protein] lead acetate promotes the reaction [Zinc Oxide results in decreased expression of BCL2 mRNA]; Zinc Oxide promotes the reaction [lead acetate results in decreased expression of BCL2 mRNA] Zinc Oxide results in increased expression of BCL2 mRNA |
CTD |
PMID:24614525 PMID:25680694 PMID:27544635 PMID:33236829 PMID:33599401 PMID:34553816 More...
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|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Becn1 |
beclin 1 |
multiple interactions increases expression |
ISO EXP |
Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased expression of BECN1 protein] Zinc Oxide results in increased expression of BECN1 mRNA; Zinc Oxide results in increased expression of BECN1 protein |
CTD |
PMID:24614525 PMID:32951350 |
|
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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G |
Bid |
BH3 interacting domain death agonist |
multiple interactions |
ISO |
Zinc Oxide affects the splicing of and affects the expression of BID mRNA |
CTD |
PMID:30500950 |
|
NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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G |
Bnip3 |
BCL2 interacting protein 3 |
increases expression |
ISO |
Zinc Oxide results in increased expression of BNIP3 mRNA |
CTD |
PMID:19755143 |
|
NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
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G |
Casp1 |
caspase 1 |
increases cleavage multiple interactions |
ISO |
Zinc Oxide analog results in increased cleavage of CASP1 protein Zinc Oxide analog promotes the reaction [OVAL protein results in increased cleavage of CASP1 protein] |
CTD |
PMID:25127755 |
|
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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G |
Casp12 |
caspase 12 |
increases expression increases activity |
EXP ISO |
Zinc Oxide results in increased expression of CASP12 mRNA Zinc Oxide analog results in increased activity of CASP12 protein |
CTD |
PMID:23232460 PMID:25680694 |
|
NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
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G |
Casp3 |
caspase 3 |
increases activity multiple interactions increases cleavage increases expression |
ISO |
Zinc Oxide analog results in increased activity of CASP3 protein; Zinc Oxide results in increased activity of CASP3 protein Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased cleavage of CASP3 protein]; MAP1LC3B mutant form inhibits the reaction [Zinc Oxide analog results in increased cleavage of CASP3 protein]; Zinc Oxide affects the splicing of and results in increased expression of CASP3 mRNA benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Zinc Oxide analog results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [Zinc Oxide analog results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP3 protein] Zinc Oxide results in increased expression of CASP3 mRNA |
CTD |
PMID:22112499 PMID:24614525 PMID:25680694 PMID:27544635 PMID:30500950 PMID:33599401 More...
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|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
multiple interactions increases cleavage increases activity |
ISO |
Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased cleavage of CASP8 protein] benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Zinc Oxide analog results in increased activity of CASP8 protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP8 protein] |
CTD |
PMID:24614525 PMID:27544635 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
increases cleavage multiple interactions increases activity |
ISO |
Zinc Oxide analog results in increased cleavage of CASP9 protein Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased cleavage of CASP9 protein] Zinc Oxide analog results in increased activity of CASP9 protein benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Zinc Oxide analog results in increased activity of CASP9 protein]; Cyclosporine inhibits the reaction [Zinc Oxide analog results in increased activity of CASP9 protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP9 protein] |
CTD |
PMID:24614525 PMID:25680694 PMID:27544635 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
decreases expression decreases activity multiple interactions |
ISO EXP |
Zinc Oxide results in decreased expression of CAT mRNA; Zinc Oxide results in decreased expression of CAT protein Zinc Oxide analog results in decreased activity of CAT protein; Zinc Oxide results in decreased activity of CAT protein Quercetin inhibits the reaction [Zinc Oxide analog results in decreased activity of CAT protein] Zinc Oxide promotes the reaction [Lipopolysaccharides results in decreased activity of CAT protein] |
CTD |
PMID:19382294 PMID:24614525 PMID:27111109 PMID:31804693 PMID:32600046 PMID:33236829 PMID:33247493 More...
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
increases expression multiple interactions increases secretion decreases expression |
ISO EXP |
Zinc Oxide analog results in increased expression of CCL2 mRNA; Zinc Oxide analog results in increased expression of CCL2 protein MYD88 mutant form inhibits the reaction [Zinc Oxide analog results in increased expression of CCL2 mRNA]; Zinc Oxide promotes the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein] Zinc Oxide analog results in increased secretion of CCL2 protein Zinc Oxide results in decreased expression of CCL2 protein |
CTD |
PMID:20851137 PMID:23352990 PMID:24746987 PMID:31804693 PMID:33205376 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl20 |
C-C motif chemokine ligand 20 |
decreases expression |
EXP |
Zinc Oxide results in decreased expression of CCL20 protein |
CTD |
PMID:33205376 |
|
NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
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G |
Ccl22 |
C-C motif chemokine ligand 22 |
decreases expression |
EXP |
Zinc Oxide results in decreased expression of CCL22 protein |
CTD |
PMID:33205376 |
|
NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
affects expression |
EXP |
Zinc Oxide affects the expression of CCL5 protein |
CTD |
PMID:33205376 |
|
NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
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G |
Cd36 |
CD36 molecule |
multiple interactions |
ISO |
[Zinc Oxide analog co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD36 protein |
CTD |
PMID:24746987 |
|
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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G |
Cd63 |
Cd63 molecule |
increases expression |
ISO |
Zinc Oxide results in increased expression of CD63 protein |
CTD |
PMID:23726862 |
|
NCBI chr 7:1,325,108...1,340,447
Ensembl chr 7:1,325,103...1,399,178
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G |
Cdc42 |
cell division cycle 42 |
multiple interactions |
ISO |
[RAC1 protein binds to CDC42 protein] affects the reaction [Zinc Oxide results in increased expression of ICAM1 protein]; NSC 23766 inhibits the reaction [Zinc Oxide results in increased activity of and results in increased phosphorylation of [RAC1 protein binds to CDC42 protein]]; Zinc Oxide results in increased activity of and results in increased phosphorylation of [RAC1 protein binds to CDC42 protein] |
CTD |
PMID:22166487 |
|
NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
Zinc Oxide analog results in increased expression of CDKN1A protein |
CTD |
PMID:24614525 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Chrm3 |
cholinergic receptor, muscarinic 3 |
multiple interactions |
ISO |
Zinc Oxide promotes the reaction [Carbachol inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]] |
CTD |
PMID:20708676 |
|
NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278
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G |
Creb5 |
cAMP responsive element binding protein 5 |
decreases expression |
ISO |
Zinc Oxide analog results in decreased expression of CREB5 mRNA |
CTD |
PMID:27185063 |
|
NCBI chr 4:82,393,091...82,794,320
Ensembl chr 4:82,393,730...82,790,325
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G |
Crym |
crystallin, mu |
decreases expression |
ISO |
Zinc Oxide analog results in decreased expression of CRYM mRNA |
CTD |
PMID:27185063 |
|
NCBI chr 1:174,560,423...174,575,660
Ensembl chr 1:174,560,416...174,575,633
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G |
Csf2 |
colony stimulating factor 2 |
multiple interactions |
ISO |
Zinc Oxide promotes the reaction [Lipopolysaccharides results in increased secretion of CSF2 protein] |
CTD |
PMID:31804693 |
|
NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
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G |
Csf3 |
colony stimulating factor 3 |
affects expression |
EXP |
Zinc Oxide affects the expression of CSF3 protein |
CTD |
PMID:33205376 |
|
NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
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G |
Cst3 |
cystatin C |
decreases expression |
EXP |
Zinc Oxide results in decreased expression of CST3 protein |
CTD |
PMID:33205376 |
|
NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822
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G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
decreases expression |
EXP |
Zinc Oxide results in decreased expression of CXCL2 protein |
CTD |
PMID:33205376 |
|
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
increases expression multiple interactions |
ISO |
Zinc Oxide analog results in increased expression of CXCL1 mRNA MYD88 mutant form inhibits the reaction [Zinc Oxide analog results in increased expression of CXCL1 mRNA] |
CTD |
PMID:23352990 |
|
NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
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G |
Cxcl9 |
C-X-C motif chemokine ligand 9 |
increases expression |
ISO |
Zinc Oxide results in increased expression of CXCL9 |
CTD |
PMID:19897006 |
|
NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435
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G |
Cycs |
cytochrome c, somatic |
increases expression |
ISO |
Zinc Oxide results in increased expression of CYCS mRNA |
CTD |
PMID:33236829 |
|
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
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G |
Cyp11a1 |
cytochrome P450, family 11, subfamily a, polypeptide 1 |
decreases expression |
ISO |
Zinc Oxide results in decreased expression of CYP11A1 mRNA |
CTD |
PMID:33236829 |
|
NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression |
ISO |
Zinc Oxide results in increased expression of CYP1A1 mRNA |
CTD |
PMID:33236829 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Dazl |
deleted in azoospermia-like |
increases expression |
ISO |
Zinc Oxide results in increased expression of DAZL mRNA |
CTD |
PMID:33098963 |
|
NCBI chr 9:10,695,572...10,712,443
Ensembl chr 9:10,695,592...10,712,323
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression |
ISO |
Zinc Oxide analog results in increased expression of DDIT3 mRNA; Zinc Oxide analog results in increased expression of DDIT3 protein |
CTD |
PMID:25680694 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Ddx4 |
DEAD-box helicase 4 |
increases expression |
ISO |
Zinc Oxide results in increased expression of DDX4 mRNA |
CTD |
PMID:33098963 |
|
NCBI chr 2:44,227,946...44,282,867
Ensembl chr 2:44,227,946...44,282,723
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G |
Dhcr7 |
7-dehydrocholesterol reductase |
multiple interactions |
ISO |
Zinc Oxide affects the splicing of and results in increased expression of DHCR7 mRNA |
CTD |
PMID:30500950 |
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NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
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G |
Dnaja4 |
DnaJ heat shock protein family (Hsp40) member A4 |
increases expression |
ISO |
Zinc Oxide results in increased expression of DNAJA4 protein |
CTD |
PMID:21769377 |
|
NCBI chr 8:55,085,246...55,102,715
Ensembl chr 8:55,085,464...55,101,207
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G |
Dppa3 |
developmental pluripotency-associated 3 |
increases expression |
ISO |
Zinc Oxide results in increased expression of DPPA3 mRNA |
CTD |
PMID:33098963 |
|
NCBI chr 4:155,851,461...155,854,845
Ensembl chr 4:155,815,296...155,854,861
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G |
Ehhadh |
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase |
multiple interactions |
ISO |
Zinc Oxide affects the splicing of and results in increased expression of EHHADH mRNA |
CTD |
PMID:30500950 |
|
NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
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G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
increases phosphorylation |
ISO |
Zinc Oxide analog results in increased phosphorylation of EIF2AK3 protein |
CTD |
PMID:25680694 |
|
NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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G |
Eif2s1 |
eukaryotic translation initiation factor 2 subunit alpha |
increases phosphorylation |
ISO |
Zinc Oxide analog results in increased phosphorylation of EIF2S1 protein |
CTD |
PMID:25680694 |
|
NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
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G |
Esr1 |
estrogen receptor 1 |
decreases expression |
ISO |
Zinc Oxide results in decreased expression of ESR1 mRNA |
CTD |
PMID:33599401 |
|
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Fas |
Fas cell surface death receptor |
multiple interactions increases expression decreases expression |
ISO |
benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Zinc Oxide analog results in increased expression of FAS protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased expression of FAS protein] Zinc Oxide affects the splicing of and results in increased expression of FAS mRNA Zinc Oxide results in decreased expression of FAS mRNA |
CTD |
PMID:27544635 PMID:30500950 PMID:32600046 |
|
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
Zinc Oxide results in increased expression of FOS protein |
CTD |
PMID:24368203 |
|
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Gadd45b |
growth arrest and DNA-damage-inducible, beta |
increases expression |
ISO |
Zinc Oxide results in increased expression of GADD45B protein |
CTD |
PMID:21769377 |
|
NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions |
ISO |
Zinc Oxide affects the splicing of and results in increased expression of GCLC mRNA |
CTD |
PMID:30500950 |
|
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
multiple interactions |
ISO |
Zinc Oxide affects the splicing of and results in increased expression of GCLM mRNA |
CTD |
PMID:30500950 |
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NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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G |
Gdf15 |
growth differentiation factor 15 |
decreases expression |
EXP |
Zinc Oxide results in decreased expression of GDF15 protein |
CTD |
PMID:33205376 |
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NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
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G |
Ggt1 |
gamma-glutamyltransferase 1 |
multiple interactions |
EXP |
[cupric oxide co-treated with lead oxide co-treated with Zinc Oxide] results in increased activity of GGT1 protein; [lead oxide co-treated with Zinc Oxide] results in increased activity of GGT1 protein |
CTD |
PMID:28212817 |
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NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
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G |
Gli1 |
GLI family zinc finger 1 |
increases expression |
ISO |
Zinc Oxide results in increased expression of GLI1 mRNA |
CTD |
PMID:33236829 |
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NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251
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G |
Gli2 |
GLI family zinc finger 2 |
increases expression |
ISO |
Zinc Oxide results in increased expression of GLI2 mRNA |
CTD |
PMID:33236829 |
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NCBI chr13:29,946,809...30,163,901
Ensembl chr13:29,946,809...30,163,574
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G |
Gli3 |
GLI family zinc finger 3 |
increases expression |
ISO |
Zinc Oxide results in increased expression of GLI3 mRNA |
CTD |
PMID:33236829 |
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NCBI chr17:49,438,567...49,709,712
Ensembl chr17:49,438,567...49,709,712
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G |
Gpt |
glutamic--pyruvic transaminase |
increases expression multiple interactions |
ISO EXP |
Zinc Oxide analog results in increased expression of GPT protein Zinc Oxide inhibits the reaction [Dimethylnitrosamine results in increased uptake of GPT protein] |
CTD |
PMID:25680694 PMID:29024620 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gsr |
glutathione-disulfide reductase |
decreases activity multiple interactions |
ISO |
Zinc Oxide analog results in decreased activity of GSR protein Zinc Oxide affects the splicing of and affects the expression of GSR mRNA |
CTD |
PMID:24614525 PMID:30500950 |
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NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Gss |
glutathione synthetase |
multiple interactions |
ISO |
Zinc Oxide affects the splicing of and results in increased expression of GSS mRNA |
CTD |
PMID:30500950 |
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NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198
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G |
H2ax |
H2A.X variant histone |
increases activity multiple interactions |
ISO |
Zinc Oxide analog results in increased activity of H2AX protein Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased activity of H2AX protein] |
CTD |
PMID:24614525 |
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NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
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G |
Hmox1 |
heme oxygenase 1 |
increases expression multiple interactions |
EXP ISO |
Zinc Oxide results in increased expression of HMOX1 mRNA; Zinc Oxide results in increased expression of HMOX1 protein Zinc Oxide affects the splicing of and results in increased expression of HMOX1 mRNA |
CTD |
PMID:21769377 PMID:22640810 PMID:29289694 PMID:30500950 PMID:33599401 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hsd17b1 |
hydroxysteroid (17-beta) dehydrogenase 1 |
increases expression |
ISO |
Zinc Oxide results in increased expression of HSD17B1 mRNA |
CTD |
PMID:33236829 |
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NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927
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G |
Hsd17b3 |
hydroxysteroid (17-beta) dehydrogenase 3 |
multiple interactions decreases expression |
EXP |
Quercetin inhibits the reaction [Zinc Oxide analog results in decreased expression of HSD17B3 mRNA] |
CTD |
PMID:27111109 |
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NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554
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G |
Hsf1 |
heat shock transcription factor 1 |
increases activity |
ISO |
Zinc Oxide results in increased activity of HSF1 protein |
CTD |
PMID:34170685 |
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NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
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G |
Hsp90b1 |
heat shock protein 90 beta family member 1 |
increases expression |
ISO |
Zinc Oxide analog results in increased expression of HSP90B1 mRNA |
CTD |
PMID:25680694 |
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NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788
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G |
Hspa1a |
heat shock protein family A (Hsp70) member 1A |
increases expression |
ISO |
Zinc Oxide results in increased expression of HSPA1A protein |
CTD |
PMID:21769377 |
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases expression |
ISO |
Zinc Oxide analog results in increased expression of HSPA5 mRNA |
CTD |
PMID:25680694 |
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NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions increases expression affects expression |
ISO EXP |
[RAC1 protein binds to CDC42 protein] affects the reaction [Zinc Oxide results in increased expression of ICAM1 protein]; BAY 11-7085 inhibits the reaction [Zinc Oxide results in increased expression of ICAM1]; JUN protein affects the reaction [Zinc Oxide results in increased expression of ICAM1 protein]; NSC 23766 inhibits the reaction [Zinc Oxide results in increased expression of ICAM1]; pyrazolanthrone inhibits the reaction [Zinc Oxide results in increased expression of ICAM1] Zinc Oxide analog results in increased expression of ICAM1 protein; Zinc Oxide results in increased expression of ICAM1 mRNA; Zinc Oxide results in increased expression of ICAM1 protein Zinc Oxide analog results in increased expression of ICAM1 protein; Zinc Oxide results in increased expression of ICAM1 protein Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of ICAM1 protein] Zinc Oxide affects the expression of ICAM1 protein |
CTD |
PMID:22166487 PMID:24746987 PMID:25127755 PMID:33205376 |
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NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Ifng |
interferon gamma |
increases expression multiple interactions |
ISO |
Zinc Oxide results in increased expression of IFNG protein Zinc Oxide affects the splicing of and results in increased expression of IFNG mRNA |
CTD |
PMID:24368203 PMID:30500950 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Igf1 |
insulin-like growth factor 1 |
affects expression |
EXP |
Zinc Oxide affects the expression of IGF1 protein |
CTD |
PMID:33205376 |
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NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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G |
Igfbp2 |
insulin-like growth factor binding protein 2 |
affects expression |
EXP |
Zinc Oxide affects the expression of IGFBP2 protein |
CTD |
PMID:33205376 |
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NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937
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G |
Il10 |
interleukin 10 |
increases expression |
ISO |
Zinc Oxide analog results in increased expression of IL10 protein; Zinc Oxide results in increased expression of IL10 protein |
CTD |
PMID:20851137 PMID:24368203 |
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il12b |
interleukin 12B |
multiple interactions |
EXP |
Zinc Oxide inhibits the reaction [Dimethylnitrosamine results in increased expression of IL12B protein] |
CTD |
PMID:29024620 |
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NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
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G |
Il1a |
interleukin 1 alpha |
affects expression |
EXP |
Zinc Oxide affects the expression of IL1A protein |
CTD |
PMID:33205376 |
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NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
increases expression multiple interactions decreases expression |
ISO EXP |
Zinc Oxide results in increased expression of IL1B Zinc Oxide analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] [Zinc Oxide analog co-treated with OVAL protein] results in increased expression of IL1B protein; Zinc Oxide promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] Zinc Oxide results in decreased expression of IL1B protein |
CTD |
PMID:19897006 PMID:24631018 PMID:25127755 PMID:31804693 PMID:33205376 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il1rn |
interleukin 1 receptor antagonist |
decreases expression |
EXP |
Zinc Oxide results in decreased expression of IL1RN protein |
CTD |
PMID:33205376 |
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NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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G |
Il3 |
interleukin 3 |
affects expression |
EXP |
Zinc Oxide affects the expression of IL3 protein |
CTD |
PMID:33205376 |
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NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066
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G |
Il4 |
interleukin 4 |
multiple interactions decreases expression |
EXP |
lead acetate promotes the reaction [Zinc Oxide results in decreased expression of IL4 protein]; Zinc Oxide promotes the reaction [lead acetate results in decreased expression of IL4 protein] |
CTD |
PMID:34553816 |
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NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Il6 |
interleukin 6 |
increases secretion multiple interactions increases expression affects expression |
EXP ISO |
Zinc Oxide results in increased secretion of IL6 protein MYD88 mutant form inhibits the reaction [Zinc Oxide analog results in increased expression of IL6 mRNA]; Zinc Oxide affects the splicing of and results in increased expression of IL6 mRNA; Zinc Oxide promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] Zinc Oxide analog results in increased expression of IL6 mRNA; Zinc Oxide results in increased expression of IL6 protein Zinc Oxide analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] Zinc Oxide analog results in increased expression of IL6 protein Zinc Oxide affects the expression of IL6 protein |
CTD |
PMID:17301066 PMID:23352990 PMID:24368203 PMID:24631018 PMID:27185063 PMID:30500950 PMID:31804693 PMID:33205376 More...
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Irak1 |
interleukin-1 receptor-associated kinase 1 |
multiple interactions |
ISO |
[Zinc Oxide analog co-treated with OVAL protein] results in increased expression of IRAK1 protein |
CTD |
PMID:25127755 |
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NCBI chr X:151,768,621...151,778,521
Ensembl chr X:151,768,777...151,778,521
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions affects localization increases expression |
ISO |
JUN protein affects the reaction [Zinc Oxide results in increased expression of ICAM1 protein]; NSC 23766 inhibits the reaction [Zinc Oxide results in increased phosphorylation of and results in increased activity of JUN protein]; pyrazolanthrone inhibits the reaction [Zinc Oxide affects the localization of JUN protein]; pyrazolanthrone inhibits the reaction [Zinc Oxide results in increased phosphorylation of and results in increased activity of JUN protein]; Zinc Oxide results in increased phosphorylation of and results in increased activity of JUN protein Zinc Oxide results in increased expression of JUN protein |
CTD |
PMID:22166487 PMID:24368203 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Lamp2 |
lysosomal-associated membrane protein 2 |
increases expression |
ISO |
Zinc Oxide results in increased expression of LAMP2 protein |
CTD |
PMID:29289694 |
|
NCBI chr X:117,173,097...117,222,090
Ensembl chr X:117,057,606...117,260,522
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G |
Lgals1 |
galectin 1 |
decreases expression |
EXP |
Zinc Oxide results in decreased expression of LGALS1 protein |
CTD |
PMID:33205376 |
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NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345
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G |
Lgals3 |
galectin 3 |
decreases expression |
EXP |
Zinc Oxide results in decreased expression of LGALS3 protein |
CTD |
PMID:33205376 |
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NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
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G |
Lyn |
LYN proto-oncogene, Src family tyrosine kinase |
multiple interactions |
ISO |
Zinc Oxide analog promotes the reaction [OVAL protein results in increased phosphorylation of LYN protein] |
CTD |
PMID:25127755 |
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NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868
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G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
multiple interactions increases expression |
ISO EXP |
MAP1LC3B mutant form inhibits the reaction [Zinc Oxide analog results in increased cleavage of CASP3 protein] Zinc Oxide results in increased expression of MAP1LC3B protein Zinc Oxide results in increased expression of MAP1LC3B mRNA; Zinc Oxide results in increased expression of MAP1LC3B protein |
CTD |
PMID:24614525 PMID:29289694 PMID:32951350 |
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NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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G |
Map3k11 |
mitogen-activated protein kinase kinase kinase 11 |
multiple interactions increases expression |
ISO |
NSC 23766 inhibits the reaction [Zinc Oxide results in increased expression of MAP3K11 protein] |
CTD |
PMID:22166487 |
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NCBI chr 1:202,975,353...202,988,655
Ensembl chr 1:202,975,353...202,988,652
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
homoorientin promotes the reaction [Zinc Oxide analog results in decreased phosphorylation of MAPK1 protein]; Zinc Oxide analog promotes the reaction [homoorientin results in decreased phosphorylation of MAPK1 protein] [Zinc Oxide results in increased abundance of Zinc] which results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:24374571 PMID:28115650 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
homoorientin promotes the reaction [Zinc Oxide analog results in decreased phosphorylation of MAPK3 protein]; Zinc Oxide analog promotes the reaction [homoorientin results in decreased phosphorylation of MAPK3 protein] [Zinc Oxide results in increased abundance of Zinc] which results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:24374571 PMID:28115650 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
increases expression |
ISO |
Zinc Oxide results in increased expression of MAPK9 mRNA |
CTD |
PMID:33599401 |
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NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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G |
Mgmt |
O-6-methylguanine-DNA methyltransferase |
increases expression |
ISO |
Zinc Oxide results in increased expression of MGMT mRNA |
CTD |
PMID:33236829 |
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NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
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G |
Mmp13 |
matrix metallopeptidase 13 |
decreases expression |
ISO |
Zinc Oxide analog results in decreased expression of MMP13 mRNA |
CTD |
PMID:27185063 |
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NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
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G |
Mmp3 |
matrix metallopeptidase 3 |
decreases expression |
EXP |
Zinc Oxide results in decreased expression of MMP3 protein |
CTD |
PMID:33205376 |
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NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
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G |
Mmp9 |
matrix metallopeptidase 9 |
increases secretion increases activity multiple interactions decreases expression |
ISO EXP |
Zinc Oxide results in increased secretion of MMP9 protein Zinc Oxide results in increased activity of MMP9 protein Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of MMP9 protein] Zinc Oxide results in decreased expression of MMP9 protein |
CTD |
PMID:23726862 PMID:25127755 PMID:33205376 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mpo |
myeloperoxidase |
increases secretion |
ISO |
Zinc Oxide results in increased secretion of MPO protein |
CTD |
PMID:23726862 |
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NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Msr1 |
macrophage scavenger receptor 1 |
multiple interactions |
ISO |
[Zinc Oxide analog co-treated with Tetradecanoylphorbol Acetate] results in increased expression of MSR1 protein |
CTD |
PMID:24746987 |
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NCBI chr16:52,717,775...52,802,890
Ensembl chr16:52,717,732...52,799,676
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G |
Mtor |
mechanistic target of rapamycin kinase |
decreases phosphorylation decreases expression |
ISO EXP |
Zinc Oxide analog results in decreased phosphorylation of MTOR protein Zinc Oxide results in decreased expression of MTOR protein modified form |
CTD |
PMID:24614525 PMID:32951350 |
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NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Myd88 |
MYD88, innate immune signal transduction adaptor |
multiple interactions |
ISO |
MYD88 mutant form inhibits the reaction [Zinc Oxide analog results in increased expression of CCL2 mRNA]; MYD88 mutant form inhibits the reaction [Zinc Oxide analog results in increased expression of CXCL1 mRNA]; MYD88 mutant form inhibits the reaction [Zinc Oxide analog results in increased expression of IL6 mRNA]; MYD88 mutant form inhibits the reaction [Zinc Oxide analog results in increased expression of TNF mRNA]; Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of MYD88 protein] |
CTD |
PMID:23352990 PMID:25127755 |
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NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
decreases expression multiple interactions |
ISO EXP |
Zinc Oxide analog results in decreased expression of NFE2L2 protein lead acetate promotes the reaction [Zinc Oxide results in increased expression of and affects the localization of NFE2L2 protein]; Zinc Oxide promotes the reaction [lead acetate results in increased expression of and affects the localization of NFE2L2 protein]; Zinc Oxide results in increased expression of and affects the localization of NFE2L2 protein |
CTD |
PMID:24614525 PMID:34553816 |
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NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
Zinc Oxide affects the splicing of and results in increased expression of NFKB1 mRNA |
CTD |
PMID:30500950 |
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NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nfkb2 |
nuclear factor kappa B subunit 2 |
multiple interactions |
ISO |
Zinc Oxide affects the splicing of and results in decreased expression of NFKB2 mRNA |
CTD |
PMID:30500950 |
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NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
Zinc Oxide results in increased phosphorylation of and results in increased degradation of NFKBIA protein |
CTD |
PMID:20194077 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nobox |
NOBOX oogenesis homeobox |
decreases expression |
ISO |
Zinc Oxide results in decreased expression of NOBOX mRNA |
CTD |
PMID:33098963 |
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NCBI chr 4:72,128,931...72,134,436
Ensembl chr 4:72,128,931...72,134,436
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G |
Nos2 |
nitric oxide synthase 2 |
increases expression |
ISO |
Zinc Oxide results in increased expression of NOS2 protein |
CTD |
PMID:24368203 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions |
ISO |
Zinc Oxide affects the splicing of and results in increased expression of NQO1 mRNA |
CTD |
PMID:30500950 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
decreases expression |
ISO |
Zinc Oxide analog results in decreased expression of NR3C1 mRNA |
CTD |
PMID:27185063 |
|
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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G |
Nr5a1 |
nuclear receptor subfamily 5, group A, member 1 |
multiple interactions decreases expression |
EXP |
Quercetin inhibits the reaction [Zinc Oxide analog results in decreased expression of NR5A1 mRNA] |
CTD |
PMID:27111109 |
|
NCBI chr 3:22,464,786...22,486,328
Ensembl chr 3:22,465,502...22,486,328
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions increases cleavage |
ISO |
Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased cleavage of PARP1 protein] |
CTD |
PMID:24614525 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pdia3 |
protein disulfide isomerase family A, member 3 |
increases expression |
ISO |
Zinc Oxide analog results in increased expression of PDIA3 mRNA |
CTD |
PMID:25680694 |
|
NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236
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G |
Pgr |
progesterone receptor |
decreases expression |
ISO |
Zinc Oxide results in decreased expression of PGR mRNA |
CTD |
PMID:33599401 |
|
NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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G |
Prdm1 |
PR/SET domain 1 |
increases expression |
ISO |
Zinc Oxide results in increased expression of PRDM1 mRNA |
CTD |
PMID:33098963 |
|
NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488
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G |
Prdx3 |
peroxiredoxin 3 |
increases expression |
ISO |
Zinc Oxide results in increased expression of PRDX3 mRNA |
CTD |
PMID:19755143 |
|
NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111
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G |
Prl |
prolactin |
decreases expression |
EXP |
Zinc Oxide results in decreased expression of PRL protein |
CTD |
PMID:33205376 |
|
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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G |
Prnp |
prion protein |
increases expression |
ISO |
Zinc Oxide results in increased expression of PRNP mRNA |
CTD |
PMID:19755143 |
|
NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937
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G |
Ptch1 |
patched 1 |
increases expression |
ISO |
Zinc Oxide results in increased expression of PTCH1 mRNA |
CTD |
PMID:33236829 |
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NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333
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Ptgs1 |
prostaglandin-endoperoxide synthase 1 |
multiple interactions |
ISO |
Zinc Oxide affects the splicing of and results in increased expression of PTGS1 mRNA |
CTD |
PMID:30500950 |
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NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
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Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
increases expression multiple interactions |
ISO |
Zinc Oxide analog results in increased expression of PTGS2 protein; Zinc Oxide results in increased expression of PTGS2 protein Zinc Oxide affects the splicing of and affects the expression of PTGS2 mRNA; Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of PTGS2 protein] |
CTD |
PMID:24368203 PMID:25127755 PMID:30500950 |
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NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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Rac1 |
Rac family small GTPase 1 |
multiple interactions |
ISO |
[RAC1 protein binds to CDC42 protein] affects the reaction [Zinc Oxide results in increased expression of ICAM1 protein]; NSC 23766 inhibits the reaction [Zinc Oxide results in increased activity of and results in increased phosphorylation of [RAC1 protein binds to CDC42 protein]]; Zinc Oxide results in increased activity of and results in increased phosphorylation of [RAC1 protein binds to CDC42 protein] |
CTD |
PMID:22166487 |
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NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
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Rad51 |
RAD51 recombinase |
multiple interactions |
ISO |
Zinc Oxide affects the splicing of and results in increased expression of RAD51 mRNA |
CTD |
PMID:30500950 |
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NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
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Rbp4 |
retinol binding protein 4 |
affects expression |
EXP |
Zinc Oxide affects the expression of RBP4 protein |
CTD |
PMID:33205376 |
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NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399
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Rela |
RELA proto-oncogene, NF-kB subunit |
increases phosphorylation multiple interactions |
ISO |
Zinc Oxide results in increased phosphorylation of RELA protein [Zinc Oxide results in increased phosphorylation of RELA protein] promotes the reaction [RELA protein binds to CXCL8 promoter]; Zinc Oxide promotes the reaction [RELA protein binds to CXCL8 promoter] |
CTD |
PMID:20194077 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Ripk1 |
receptor interacting serine/threonine kinase 1 |
increases expression |
ISO |
Zinc Oxide results in increased expression of RIPK1 mRNA |
CTD |
PMID:32600046 |
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NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
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Ripk2 |
receptor-interacting serine-threonine kinase 2 |
multiple interactions |
ISO |
Zinc Oxide affects the splicing of and results in increased expression of RIPK2 mRNA |
CTD |
PMID:30500950 |
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NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657
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Serpine1 |
serpin family E member 1 |
decreases expression |
EXP |
Zinc Oxide results in decreased expression of SERPINE1 protein |
CTD |
PMID:33205376 |
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NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Slc11a2 |
solute carrier family 11 member 2 |
multiple interactions |
ISO |
Zinc Oxide affects the splicing of and results in decreased expression of SLC11A2 mRNA |
CTD |
PMID:30500950 |
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NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145
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Slc12a1 |
solute carrier family 12 member 1 |
decreases expression |
ISO |
Zinc Oxide analog results in decreased expression of SLC12A1 mRNA |
CTD |
PMID:27185063 |
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NCBI chr 3:112,406,140...112,482,913
Ensembl chr 3:112,406,140...112,482,899
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Slc30a1 |
solute carrier family 30 member 1 |
increases expression |
ISO |
Zinc Oxide results in increased expression of SLC30A1 mRNA |
CTD |
PMID:29289694 PMID:33599401 |
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NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910
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Smo |
smoothened, frizzled class receptor |
increases expression |
ISO |
Zinc Oxide results in increased expression of SMO mRNA |
CTD |
PMID:33236829 |
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NCBI chr 4:58,344,101...58,372,828
Ensembl chr 4:58,343,529...58,373,829
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Sod1 |
superoxide dismutase 1 |
increases expression |
ISO |
Zinc Oxide results in increased expression of SOD1 mRNA |
CTD |
PMID:32600046 |
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NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Sod2 |
superoxide dismutase 2 |
increases expression |
ISO |
Zinc Oxide results in increased expression of SOD2 mRNA |
CTD |
PMID:32600046 |
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NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Spp1 |
secreted phosphoprotein 1 |
decreases expression |
EXP |
Zinc Oxide results in decreased expression of SPP1 protein |
CTD |
PMID:33205376 |
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NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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Sqstm1 |
sequestosome 1 |
increases expression |
ISO |
Zinc Oxide results in increased expression of SQSTM1 protein |
CTD |
PMID:29289694 |
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NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
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Srxn1 |
sulfiredoxin 1 |
multiple interactions |
ISO |
Zinc Oxide affects the splicing of and results in increased expression of SRXN1 mRNA |
CTD |
PMID:30500950 |
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NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
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Star |
steroidogenic acute regulatory protein |
decreases expression |
ISO |
Zinc Oxide results in decreased expression of STAR mRNA |
CTD |
PMID:33236829 |
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NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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Stat1 |
signal transducer and activator of transcription 1 |
decreases expression |
ISO |
Zinc Oxide analog results in decreased expression of STAT1 mRNA |
CTD |
PMID:27185063 |
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NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
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Stra8 |
stimulated by retinoic acid 8 |
decreases expression |
ISO |
Zinc Oxide results in decreased expression of STRA8 mRNA |
CTD |
PMID:33098963 |
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NCBI chr 4:63,601,443...63,624,777
Ensembl chr 4:63,601,604...63,624,771
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Syk |
spleen associated tyrosine kinase |
multiple interactions |
ISO |
[Zinc Oxide analog co-treated with OVAL protein] results in increased phosphorylation of SYK protein |
CTD |
PMID:25127755 |
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NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410
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Tert |
telomerase reverse transcriptase |
increases expression |
ISO |
Zinc Oxide results in increased expression of TERT mRNA |
CTD |
PMID:33098963 |
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NCBI chr 1:29,637,213...29,659,509
Ensembl chr 1:29,637,506...29,659,561
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Tlr1 |
toll-like receptor 1 |
multiple interactions |
ISO |
Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of TLR1 mRNA] |
CTD |
PMID:25127755 |
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NCBI chr14:43,384,127...43,396,765
Ensembl chr14:43,384,932...43,397,125
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Tlr2 |
toll-like receptor 2 |
multiple interactions |
ISO |
[Zinc Oxide analog co-treated with OVAL protein] results in increased expression of TLR2 protein; Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of TLR2 mRNA] |
CTD |
PMID:25127755 |
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NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
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Tlr4 |
toll-like receptor 4 |
multiple interactions |
ISO |
[Zinc Oxide analog co-treated with OVAL protein] results in increased expression of TLR4 protein; Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of TLR4 mRNA] |
CTD |
PMID:25127755 |
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NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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Tlr6 |
toll-like receptor 6 |
multiple interactions increases expression |
ISO |
[Zinc Oxide analog co-treated with OVAL protein] results in increased expression of TLR6 protein; Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of TLR6 mRNA] Zinc Oxide analog results in increased expression of TLR6 mRNA |
CTD |
PMID:25127755 |
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NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685
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Tnf |
tumor necrosis factor |
increases expression multiple interactions decreases expression |
ISO EXP |
Zinc Oxide analog results in increased expression of TNF mRNA; Zinc Oxide results in increased expression of TNF protein MYD88 mutant form inhibits the reaction [Zinc Oxide analog results in increased expression of TNF mRNA] lead acetate promotes the reaction [Zinc Oxide results in increased expression of TNF protein]; Zinc Oxide inhibits the reaction [Dimethylnitrosamine results in increased expression of TNF protein]; Zinc Oxide promotes the reaction [lead acetate results in increased expression of TNF protein] Zinc Oxide results in decreased expression of TNF protein |
CTD |
PMID:23352990 PMID:24368203 PMID:29024620 PMID:33205376 PMID:34553816 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tp53 |
tumor protein p53 |
multiple interactions increases expression |
ISO |
Zinc Oxide results in increased phosphorylation of and results in increased expression of TP53 protein Zinc Oxide analog results in increased expression of TRP53 protein |
CTD |
PMID:21903158 PMID:24614525 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Traf6 |
TNF receptor associated factor 6 |
multiple interactions |
ISO |
[Zinc Oxide analog co-treated with OVAL protein] results in increased expression of TRAF6 protein; Zinc Oxide affects the splicing of and results in increased expression of TRAF6 mRNA |
CTD |
PMID:25127755 PMID:30500950 |
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NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507
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Tshb |
thyroid stimulating hormone subunit beta |
multiple interactions decreases secretion |
EXP |
lead acetate promotes the reaction [Zinc Oxide results in decreased secretion of TSHB protein]; Zinc Oxide promotes the reaction [lead acetate results in decreased secretion of TSHB protein] |
CTD |
PMID:34553816 |
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NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
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Txnrd1 |
thioredoxin reductase 1 |
increases expression multiple interactions |
ISO |
Zinc Oxide results in increased expression of TXNRD1 mRNA Zinc Oxide affects the splicing of and affects the expression of TXNRD1 mRNA |
CTD |
PMID:19755143 PMID:30500950 |
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NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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Vdac1 |
voltage-dependent anion channel 1 |
increases expression |
ISO |
Zinc Oxide results in increased expression of VDAC1 mRNA |
CTD |
PMID:33236829 |
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NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
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Xbp1 |
X-box binding protein 1 |
increases expression |
ISO |
Zinc Oxide analog results in increased expression of XBP1 mRNA |
CTD |
PMID:25680694 |
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NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
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Zfp36 |
zinc finger protein 36 |
increases expression |
ISO |
Zinc Oxide results in increased expression of ZFP36 protein |
CTD |
PMID:21769377 |
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NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564
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