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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:zinc oxide
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Accession:CHEBI:36560 term browser browse the term
Definition:A zinc molecular entity that has formula OZn.
Synonyms:related_synonym: Formula=OZn;   InChI=1S/O.Zn;   InChIKey=XLOMVQKBTHCTTD-UHFFFAOYSA-N;   SMILES=O=[Zn];   Zinkoxid;   ZnO;   oxido de cinc;   oxyde de zinc
 alt_id: CHEBI:30186;   CHEBI:32311
 xref: CAS:1314-13-2;   Drug_Central:4240;   Gmelin:13738;   KEGG:D01170
 xref_mesh: MESH:D015034
 xref: PPDB:1321;   Wikipedia:Zinc_Oxide


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zinc oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase increases expression ISO Zinc Oxide results in increased expression of ACHE protein CTD PMID:33247493 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Adrb1 adrenoceptor beta 1 decreases expression ISO Zinc Oxide analog results in decreased expression of ADRB1 mRNA CTD PMID:27185063 NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Adrb3 adrenoceptor beta 3 decreases expression ISO Zinc Oxide analog results in decreased expression of ADRB3 mRNA CTD PMID:27185063 NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases expression ISO Zinc Oxide analog results in decreased expression of AGTR1 mRNA CTD PMID:27185063 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation		 ISO homoorientin promotes the reaction [Zinc Oxide analog results in decreased phosphorylation of AKT1 protein]; Zinc Oxide analog promotes the reaction [homoorientin results in decreased phosphorylation of AKT1 protein]
[Zinc Oxide results in increased abundance of Zinc] which results in increased phosphorylation of AKT1 protein		 CTD PMID:24374571 PMID:24614525 PMID:28115650 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alb albumin increases secretion
multiple interactions
increases response to substance
affects binding		 ISO
EXP		 Zinc Oxide results in increased secretion of ALB protein
[cupric oxide co-treated with lead oxide co-treated with Zinc Oxide] results in decreased expression of ALB protein
ALB protein results in increased susceptibility to Zinc Oxide
Zinc Oxide binds to ALB protein
ALB protein promotes the reaction [Zinc Oxide binds to Dimethoate]		 CTD PMID:23726862 PMID:27441385 PMID:28212817 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 multiple interactions ISO Zinc Oxide affects the splicing of and results in increased expression of ALDH3A1 mRNA CTD PMID:30500950 NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions ISO Zinc Oxide affects the splicing of and results in increased expression of APAF1 mRNA CTD PMID:30500950 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Ar androgen receptor increases expression ISO Zinc Oxide results in increased expression of AR mRNA CTD PMID:22083529 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Atg10 autophagy related 10 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased expression of ATG10 mRNA] CTD PMID:24614525 NCBI chr 2:22,109,304...22,398,313
Ensembl chr 2:22,108,426...22,398,233 		JBrowse link
G Atg12 autophagy related 12 increases expression
multiple interactions		 ISO Zinc Oxide analog results in increased expression of ATG12 mRNA
Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased expression of ATG12 mRNA]		 CTD PMID:24614525 NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418 		JBrowse link
G Atg5 autophagy related 5 increases expression
multiple interactions		 ISO
EXP		 Zinc Oxide analog results in increased expression of ATG5 mRNA
Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased expression of ATG5 mRNA]
Zinc Oxide results in increased expression of ATG5 mRNA		 CTD PMID:24614525 PMID:32951350 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Atg7 autophagy related 7 increases expression EXP Zinc Oxide results in increased expression of ATG7 mRNA CTD PMID:32951350 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 decreases expression ISO Zinc Oxide analog results in decreased expression of ATP2A2 mRNA CTD PMID:27185063 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 decreases expression ISO Zinc Oxide analog results in decreased expression of ATP2B1 mRNA; Zinc Oxide analog results in decreased expression of ATP2B1 protein CTD PMID:24060544 NCBI chr 7:33,735,595...33,845,226
Ensembl chr 7:33,735,871...33,843,295 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
affects expression		 ISO
EXP		 Zinc Oxide analog results in increased expression of BAX mRNA; Zinc Oxide analog results in increased expression of BAX protein; Zinc Oxide results in increased expression of BAX mRNA
Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased expression of BAX protein]
lead acetate promotes the reaction [Zinc Oxide results in increased expression of BAX mRNA]; Zinc Oxide promotes the reaction [lead acetate results in increased expression of BAX mRNA]
Zinc Oxide affects the expression of BAX mRNA		 CTD PMID:24614525 PMID:25680694 PMID:27544635 PMID:33236829 PMID:33599401 More... NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bche butyrylcholinesterase decreases activity ISO Zinc Oxide results in decreased activity of BCHE protein CTD PMID:27441385 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
increases expression		 ISO
EXP		 Zinc Oxide analog results in decreased expression of BCL2 mRNA; Zinc Oxide analog results in decreased expression of BCL2 protein; Zinc Oxide results in decreased expression of BCL2 mRNA
Thioctic Acid inhibits the reaction [Zinc Oxide analog results in decreased expression of BCL2 protein]
lead acetate promotes the reaction [Zinc Oxide results in decreased expression of BCL2 mRNA]; Zinc Oxide promotes the reaction [lead acetate results in decreased expression of BCL2 mRNA]
Zinc Oxide results in increased expression of BCL2 mRNA		 CTD PMID:24614525 PMID:25680694 PMID:27544635 PMID:33236829 PMID:33599401 More... NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression		 ISO
EXP		 Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased expression of BECN1 protein]
Zinc Oxide results in increased expression of BECN1 mRNA; Zinc Oxide results in increased expression of BECN1 protein		 CTD PMID:24614525 PMID:32951350 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO Zinc Oxide affects the splicing of and affects the expression of BID mRNA CTD PMID:30500950 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression ISO Zinc Oxide results in increased expression of BNIP3 mRNA CTD PMID:19755143 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Casp1 caspase 1 increases cleavage
multiple interactions		 ISO Zinc Oxide analog results in increased cleavage of CASP1 protein
Zinc Oxide analog promotes the reaction [OVAL protein results in increased cleavage of CASP1 protein]		 CTD PMID:25127755 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp12 caspase 12 increases expression
increases activity		 EXP
ISO		 Zinc Oxide results in increased expression of CASP12 mRNA
Zinc Oxide analog results in increased activity of CASP12 protein		 CTD PMID:23232460 PMID:25680694 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases cleavage
increases expression		 ISO Zinc Oxide analog results in increased activity of CASP3 protein; Zinc Oxide results in increased activity of CASP3 protein
Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased cleavage of CASP3 protein]; MAP1LC3B mutant form inhibits the reaction [Zinc Oxide analog results in increased cleavage of CASP3 protein]; Zinc Oxide affects the splicing of and results in increased expression of CASP3 mRNA
benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Zinc Oxide analog results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [Zinc Oxide analog results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP3 protein]
Zinc Oxide results in increased expression of CASP3 mRNA		 CTD PMID:22112499 PMID:24614525 PMID:25680694 PMID:27544635 PMID:30500950 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage
increases activity		 ISO Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased cleavage of CASP8 protein]
benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Zinc Oxide analog results in increased activity of CASP8 protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP8 protein]		 CTD PMID:24614525 PMID:27544635 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions
increases activity		 ISO Zinc Oxide analog results in increased cleavage of CASP9 protein
Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased cleavage of CASP9 protein]
Zinc Oxide analog results in increased activity of CASP9 protein
benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Zinc Oxide analog results in increased activity of CASP9 protein]; Cyclosporine inhibits the reaction [Zinc Oxide analog results in increased activity of CASP9 protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP9 protein]		 CTD PMID:24614525 PMID:25680694 PMID:27544635 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase decreases expression
decreases activity
multiple interactions		 ISO
EXP		 Zinc Oxide results in decreased expression of CAT mRNA; Zinc Oxide results in decreased expression of CAT protein
Zinc Oxide analog results in decreased activity of CAT protein; Zinc Oxide results in decreased activity of CAT protein
Quercetin inhibits the reaction [Zinc Oxide analog results in decreased activity of CAT protein]
Zinc Oxide promotes the reaction [Lipopolysaccharides results in decreased activity of CAT protein]		 CTD PMID:19382294 PMID:24614525 PMID:27111109 PMID:31804693 PMID:32600046 More... NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions
increases secretion
decreases expression		 ISO
EXP		 Zinc Oxide analog results in increased expression of CCL2 mRNA; Zinc Oxide analog results in increased expression of CCL2 protein
MYD88 mutant form inhibits the reaction [Zinc Oxide analog results in increased expression of CCL2 mRNA]; Zinc Oxide promotes the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]
Zinc Oxide analog results in increased secretion of CCL2 protein
Zinc Oxide results in decreased expression of CCL2 protein		 CTD PMID:20851137 PMID:23352990 PMID:24746987 PMID:31804693 PMID:33205376 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 decreases expression EXP Zinc Oxide results in decreased expression of CCL20 protein CTD PMID:33205376 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629 		JBrowse link
G Ccl22 C-C motif chemokine ligand 22 decreases expression EXP Zinc Oxide results in decreased expression of CCL22 protein CTD PMID:33205376 NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 affects expression EXP Zinc Oxide affects the expression of CCL5 protein CTD PMID:33205376 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Cd36 CD36 molecule multiple interactions ISO [Zinc Oxide analog co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD36 protein CTD PMID:24746987 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Cd63 Cd63 molecule increases expression ISO Zinc Oxide results in increased expression of CD63 protein CTD PMID:23726862 NCBI chr 7:1,325,108...1,340,447
Ensembl chr 7:1,325,103...1,399,178 		JBrowse link
G Cdc42 cell division cycle 42 multiple interactions ISO [RAC1 protein binds to CDC42 protein] affects the reaction [Zinc Oxide results in increased expression of ICAM1 protein]; NSC 23766 inhibits the reaction [Zinc Oxide results in increased activity of and results in increased phosphorylation of [RAC1 protein binds to CDC42 protein]]; Zinc Oxide results in increased activity of and results in increased phosphorylation of [RAC1 protein binds to CDC42 protein] CTD PMID:22166487 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Zinc Oxide analog results in increased expression of CDKN1A protein CTD PMID:24614525 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 multiple interactions ISO Zinc Oxide promotes the reaction [Carbachol inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]] CTD PMID:20708676 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278 		JBrowse link
G Creb5 cAMP responsive element binding protein 5 decreases expression ISO Zinc Oxide analog results in decreased expression of CREB5 mRNA CTD PMID:27185063 NCBI chr 4:82,393,091...82,794,320
Ensembl chr 4:82,393,730...82,790,325 		JBrowse link
G Crym crystallin, mu decreases expression ISO Zinc Oxide analog results in decreased expression of CRYM mRNA CTD PMID:27185063 NCBI chr 1:174,560,423...174,575,660
Ensembl chr 1:174,560,416...174,575,633 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Zinc Oxide promotes the reaction [Lipopolysaccharides results in increased secretion of CSF2 protein] CTD PMID:31804693 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Csf3 colony stimulating factor 3 affects expression EXP Zinc Oxide affects the expression of CSF3 protein CTD PMID:33205376 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603 		JBrowse link
G Cst3 cystatin C decreases expression EXP Zinc Oxide results in decreased expression of CST3 protein CTD PMID:33205376 NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 decreases expression EXP Zinc Oxide results in decreased expression of CXCL2 protein CTD PMID:33205376 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression
multiple interactions		 ISO Zinc Oxide analog results in increased expression of CXCL1 mRNA
MYD88 mutant form inhibits the reaction [Zinc Oxide analog results in increased expression of CXCL1 mRNA]		 CTD PMID:23352990 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 increases expression ISO Zinc Oxide results in increased expression of CXCL9 CTD PMID:19897006 NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435 		JBrowse link
G Cycs cytochrome c, somatic increases expression ISO Zinc Oxide results in increased expression of CYCS mRNA CTD PMID:33236829 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression ISO Zinc Oxide results in decreased expression of CYP11A1 mRNA CTD PMID:33236829 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Zinc Oxide results in increased expression of CYP1A1 mRNA CTD PMID:33236829 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Dazl deleted in azoospermia-like increases expression ISO Zinc Oxide results in increased expression of DAZL mRNA CTD PMID:33098963 NCBI chr 9:10,695,572...10,712,443
Ensembl chr 9:10,695,592...10,712,323 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Zinc Oxide analog results in increased expression of DDIT3 mRNA; Zinc Oxide analog results in increased expression of DDIT3 protein CTD PMID:25680694 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Ddx4 DEAD-box helicase 4 increases expression ISO Zinc Oxide results in increased expression of DDX4 mRNA CTD PMID:33098963 NCBI chr 2:44,227,946...44,282,867
Ensembl chr 2:44,227,946...44,282,723 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase multiple interactions ISO Zinc Oxide affects the splicing of and results in increased expression of DHCR7 mRNA CTD PMID:30500950 NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055 		JBrowse link
G Dnaja4 DnaJ heat shock protein family (Hsp40) member A4 increases expression ISO Zinc Oxide results in increased expression of DNAJA4 protein CTD PMID:21769377 NCBI chr 8:55,085,246...55,102,715
Ensembl chr 8:55,085,464...55,101,207 		JBrowse link
G Dppa3 developmental pluripotency-associated 3 increases expression ISO Zinc Oxide results in increased expression of DPPA3 mRNA CTD PMID:33098963 NCBI chr 4:155,851,461...155,854,845
Ensembl chr 4:155,815,296...155,854,861 		JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase multiple interactions ISO Zinc Oxide affects the splicing of and results in increased expression of EHHADH mRNA CTD PMID:30500950 NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation ISO Zinc Oxide analog results in increased phosphorylation of EIF2AK3 protein CTD PMID:25680694 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO Zinc Oxide analog results in increased phosphorylation of EIF2S1 protein CTD PMID:25680694 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO Zinc Oxide results in decreased expression of ESR1 mRNA CTD PMID:33599401 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression
decreases expression		 ISO benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Zinc Oxide analog results in increased expression of FAS protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased expression of FAS protein]
Zinc Oxide affects the splicing of and results in increased expression of FAS mRNA
Zinc Oxide results in decreased expression of FAS mRNA		 CTD PMID:27544635 PMID:30500950 PMID:32600046 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Zinc Oxide results in increased expression of FOS protein CTD PMID:24368203 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta increases expression ISO Zinc Oxide results in increased expression of GADD45B protein CTD PMID:21769377 NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO Zinc Oxide affects the splicing of and results in increased expression of GCLC mRNA CTD PMID:30500950 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO Zinc Oxide affects the splicing of and results in increased expression of GCLM mRNA CTD PMID:30500950 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gdf15 growth differentiation factor 15 decreases expression EXP Zinc Oxide results in decreased expression of GDF15 protein CTD PMID:33205376 NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions EXP [cupric oxide co-treated with lead oxide co-treated with Zinc Oxide] results in increased activity of GGT1 protein; [lead oxide co-treated with Zinc Oxide] results in increased activity of GGT1 protein CTD PMID:28212817 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442 		JBrowse link
G Gli1 GLI family zinc finger 1 increases expression ISO Zinc Oxide results in increased expression of GLI1 mRNA CTD PMID:33236829 NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251 		JBrowse link
G Gli2 GLI family zinc finger 2 increases expression ISO Zinc Oxide results in increased expression of GLI2 mRNA CTD PMID:33236829 NCBI chr13:29,946,809...30,163,901
Ensembl chr13:29,946,809...30,163,574 		JBrowse link
G Gli3 GLI family zinc finger 3 increases expression ISO Zinc Oxide results in increased expression of GLI3 mRNA CTD PMID:33236829 NCBI chr17:49,438,567...49,709,712
Ensembl chr17:49,438,567...49,709,712 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression
multiple interactions		 ISO
EXP		 Zinc Oxide analog results in increased expression of GPT protein
Zinc Oxide inhibits the reaction [Dimethylnitrosamine results in increased uptake of GPT protein]		 CTD PMID:25680694 PMID:29024620 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gsr glutathione-disulfide reductase decreases activity
multiple interactions		 ISO Zinc Oxide analog results in decreased activity of GSR protein
Zinc Oxide affects the splicing of and affects the expression of GSR mRNA		 CTD PMID:24614525 PMID:30500950 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gss glutathione synthetase multiple interactions ISO Zinc Oxide affects the splicing of and results in increased expression of GSS mRNA CTD PMID:30500950 NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198 		JBrowse link
G H2ax H2A.X variant histone increases activity
multiple interactions		 ISO Zinc Oxide analog results in increased activity of H2AX protein
Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased activity of H2AX protein]		 CTD PMID:24614525 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 EXP
ISO		 Zinc Oxide results in increased expression of HMOX1 mRNA; Zinc Oxide results in increased expression of HMOX1 protein
Zinc Oxide affects the splicing of and results in increased expression of HMOX1 mRNA		 CTD PMID:21769377 PMID:22640810 PMID:29289694 PMID:30500950 PMID:33599401 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 increases expression ISO Zinc Oxide results in increased expression of HSD17B1 mRNA CTD PMID:33236829 NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927 		JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 multiple interactions
decreases expression		 EXP Quercetin inhibits the reaction [Zinc Oxide analog results in decreased expression of HSD17B3 mRNA] CTD PMID:27111109 NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554 		JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO Zinc Oxide results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 increases expression ISO Zinc Oxide analog results in increased expression of HSP90B1 mRNA CTD PMID:25680694 NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO Zinc Oxide results in increased expression of HSPA1A protein CTD PMID:21769377
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Zinc Oxide analog results in increased expression of HSPA5 mRNA CTD PMID:25680694 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
increases expression
affects expression		 ISO
EXP		 [RAC1 protein binds to CDC42 protein] affects the reaction [Zinc Oxide results in increased expression of ICAM1 protein]; BAY 11-7085 inhibits the reaction [Zinc Oxide results in increased expression of ICAM1]; JUN protein affects the reaction [Zinc Oxide results in increased expression of ICAM1 protein]; NSC 23766 inhibits the reaction [Zinc Oxide results in increased expression of ICAM1]; pyrazolanthrone inhibits the reaction [Zinc Oxide results in increased expression of ICAM1]
Zinc Oxide analog results in increased expression of ICAM1 protein; Zinc Oxide results in increased expression of ICAM1 mRNA; Zinc Oxide results in increased expression of ICAM1 protein
Zinc Oxide analog results in increased expression of ICAM1 protein; Zinc Oxide results in increased expression of ICAM1 protein
Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of ICAM1 protein]
Zinc Oxide affects the expression of ICAM1 protein		 CTD PMID:22166487 PMID:24746987 PMID:25127755 PMID:33205376 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma increases expression
multiple interactions		 ISO Zinc Oxide results in increased expression of IFNG protein
Zinc Oxide affects the splicing of and results in increased expression of IFNG mRNA		 CTD PMID:24368203 PMID:30500950 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igf1 insulin-like growth factor 1 affects expression EXP Zinc Oxide affects the expression of IGF1 protein CTD PMID:33205376 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 affects expression EXP Zinc Oxide affects the expression of IGFBP2 protein CTD PMID:33205376 NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937 		JBrowse link
G Il10 interleukin 10 increases expression ISO Zinc Oxide analog results in increased expression of IL10 protein; Zinc Oxide results in increased expression of IL10 protein CTD PMID:20851137 PMID:24368203 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il12b interleukin 12B multiple interactions EXP Zinc Oxide inhibits the reaction [Dimethylnitrosamine results in increased expression of IL12B protein] CTD PMID:29024620 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il1a interleukin 1 alpha affects expression EXP Zinc Oxide affects the expression of IL1A protein CTD PMID:33205376 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
decreases expression		 ISO
EXP		 Zinc Oxide results in increased expression of IL1B
Zinc Oxide analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
[Zinc Oxide analog co-treated with OVAL protein] results in increased expression of IL1B protein; Zinc Oxide promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
Zinc Oxide results in decreased expression of IL1B protein		 CTD PMID:19897006 PMID:24631018 PMID:25127755 PMID:31804693 PMID:33205376 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1rn interleukin 1 receptor antagonist decreases expression EXP Zinc Oxide results in decreased expression of IL1RN protein CTD PMID:33205376 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il3 interleukin 3 affects expression EXP Zinc Oxide affects the expression of IL3 protein CTD PMID:33205376 NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066 		JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression		 EXP lead acetate promotes the reaction [Zinc Oxide results in decreased expression of IL4 protein]; Zinc Oxide promotes the reaction [lead acetate results in decreased expression of IL4 protein] CTD PMID:34553816 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 increases secretion
multiple interactions
increases expression
affects expression		 EXP
ISO		 Zinc Oxide results in increased secretion of IL6 protein
MYD88 mutant form inhibits the reaction [Zinc Oxide analog results in increased expression of IL6 mRNA]; Zinc Oxide affects the splicing of and results in increased expression of IL6 mRNA; Zinc Oxide promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
Zinc Oxide analog results in increased expression of IL6 mRNA; Zinc Oxide results in increased expression of IL6 protein
Zinc Oxide analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
Zinc Oxide analog results in increased expression of IL6 protein
Zinc Oxide affects the expression of IL6 protein		 CTD PMID:17301066 PMID:23352990 PMID:24368203 PMID:24631018 PMID:27185063 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO [Zinc Oxide analog co-treated with OVAL protein] results in increased expression of IRAK1 protein CTD PMID:25127755 NCBI chr  X:151,768,621...151,778,521
Ensembl chr  X:151,768,777...151,778,521 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
affects localization
increases expression		 ISO JUN protein affects the reaction [Zinc Oxide results in increased expression of ICAM1 protein]; NSC 23766 inhibits the reaction [Zinc Oxide results in increased phosphorylation of and results in increased activity of JUN protein]; pyrazolanthrone inhibits the reaction [Zinc Oxide affects the localization of JUN protein]; pyrazolanthrone inhibits the reaction [Zinc Oxide results in increased phosphorylation of and results in increased activity of JUN protein]; Zinc Oxide results in increased phosphorylation of and results in increased activity of JUN protein
Zinc Oxide results in increased expression of JUN protein		 CTD PMID:22166487 PMID:24368203 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 increases expression ISO Zinc Oxide results in increased expression of LAMP2 protein CTD PMID:29289694 NCBI chr  X:117,173,097...117,222,090
Ensembl chr  X:117,057,606...117,260,522 		JBrowse link
G Lgals1 galectin 1 decreases expression EXP Zinc Oxide results in decreased expression of LGALS1 protein CTD PMID:33205376 NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345 		JBrowse link
G Lgals3 galectin 3 decreases expression EXP Zinc Oxide results in decreased expression of LGALS3 protein CTD PMID:33205376 NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase multiple interactions ISO Zinc Oxide analog promotes the reaction [OVAL protein results in increased phosphorylation of LYN protein] CTD PMID:25127755 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression		 ISO
EXP		 MAP1LC3B mutant form inhibits the reaction [Zinc Oxide analog results in increased cleavage of CASP3 protein]
Zinc Oxide results in increased expression of MAP1LC3B protein
Zinc Oxide results in increased expression of MAP1LC3B mRNA; Zinc Oxide results in increased expression of MAP1LC3B protein		 CTD PMID:24614525 PMID:29289694 PMID:32951350 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Map3k11 mitogen-activated protein kinase kinase kinase 11 multiple interactions
increases expression		 ISO NSC 23766 inhibits the reaction [Zinc Oxide results in increased expression of MAP3K11 protein] CTD PMID:22166487 NCBI chr 1:202,975,353...202,988,655
Ensembl chr 1:202,975,353...202,988,652 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO homoorientin promotes the reaction [Zinc Oxide analog results in decreased phosphorylation of MAPK1 protein]; Zinc Oxide analog promotes the reaction [homoorientin results in decreased phosphorylation of MAPK1 protein]
[Zinc Oxide results in increased abundance of Zinc] which results in increased phosphorylation of MAPK1 protein		 CTD PMID:24374571 PMID:28115650 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO homoorientin promotes the reaction [Zinc Oxide analog results in decreased phosphorylation of MAPK3 protein]; Zinc Oxide analog promotes the reaction [homoorientin results in decreased phosphorylation of MAPK3 protein]
[Zinc Oxide results in increased abundance of Zinc] which results in increased phosphorylation of MAPK3 protein		 CTD PMID:24374571 PMID:28115650 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases expression ISO Zinc Oxide results in increased expression of MAPK9 mRNA CTD PMID:33599401 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression ISO Zinc Oxide results in increased expression of MGMT mRNA CTD PMID:33236829 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756 		JBrowse link
G Mmp13 matrix metallopeptidase 13 decreases expression ISO Zinc Oxide analog results in decreased expression of MMP13 mRNA CTD PMID:27185063 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
G Mmp3 matrix metallopeptidase 3 decreases expression EXP Zinc Oxide results in decreased expression of MMP3 protein CTD PMID:33205376 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases secretion
increases activity
multiple interactions
decreases expression		 ISO
EXP		 Zinc Oxide results in increased secretion of MMP9 protein
Zinc Oxide results in increased activity of MMP9 protein
Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of MMP9 protein]
Zinc Oxide results in decreased expression of MMP9 protein		 CTD PMID:23726862 PMID:25127755 PMID:33205376 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase increases secretion ISO Zinc Oxide results in increased secretion of MPO protein CTD PMID:23726862 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Msr1 macrophage scavenger receptor 1 multiple interactions ISO [Zinc Oxide analog co-treated with Tetradecanoylphorbol Acetate] results in increased expression of MSR1 protein CTD PMID:24746987 NCBI chr16:52,717,775...52,802,890
Ensembl chr16:52,717,732...52,799,676 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation
decreases expression		 ISO
EXP		 Zinc Oxide analog results in decreased phosphorylation of MTOR protein
Zinc Oxide results in decreased expression of MTOR protein modified form		 CTD PMID:24614525 PMID:32951350 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO MYD88 mutant form inhibits the reaction [Zinc Oxide analog results in increased expression of CCL2 mRNA]; MYD88 mutant form inhibits the reaction [Zinc Oxide analog results in increased expression of CXCL1 mRNA]; MYD88 mutant form inhibits the reaction [Zinc Oxide analog results in increased expression of IL6 mRNA]; MYD88 mutant form inhibits the reaction [Zinc Oxide analog results in increased expression of TNF mRNA]; Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of MYD88 protein] CTD PMID:23352990 PMID:25127755 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases expression
multiple interactions		 ISO
EXP		 Zinc Oxide analog results in decreased expression of NFE2L2 protein
lead acetate promotes the reaction [Zinc Oxide results in increased expression of and affects the localization of NFE2L2 protein]; Zinc Oxide promotes the reaction [lead acetate results in increased expression of and affects the localization of NFE2L2 protein]; Zinc Oxide results in increased expression of and affects the localization of NFE2L2 protein		 CTD PMID:24614525 PMID:34553816 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Zinc Oxide affects the splicing of and results in increased expression of NFKB1 mRNA CTD PMID:30500950 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 multiple interactions ISO Zinc Oxide affects the splicing of and results in decreased expression of NFKB2 mRNA CTD PMID:30500950 NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Zinc Oxide results in increased phosphorylation of and results in increased degradation of NFKBIA protein CTD PMID:20194077 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nobox NOBOX oogenesis homeobox decreases expression ISO Zinc Oxide results in decreased expression of NOBOX mRNA CTD PMID:33098963 NCBI chr 4:72,128,931...72,134,436
Ensembl chr 4:72,128,931...72,134,436 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO Zinc Oxide results in increased expression of NOS2 protein CTD PMID:24368203 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO Zinc Oxide affects the splicing of and results in increased expression of NQO1 mRNA CTD PMID:30500950 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases expression ISO Zinc Oxide analog results in decreased expression of NR3C1 mRNA CTD PMID:27185063 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 multiple interactions
decreases expression		 EXP Quercetin inhibits the reaction [Zinc Oxide analog results in decreased expression of NR5A1 mRNA] CTD PMID:27111109 NCBI chr 3:22,464,786...22,486,328
Ensembl chr 3:22,465,502...22,486,328 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 ISO Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased cleavage of PARP1 protein] CTD PMID:24614525 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 increases expression ISO Zinc Oxide analog results in increased expression of PDIA3 mRNA CTD PMID:25680694 NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236 		JBrowse link
G Pgr progesterone receptor decreases expression ISO Zinc Oxide results in decreased expression of PGR mRNA CTD PMID:33599401 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Prdm1 PR/SET domain 1 increases expression ISO Zinc Oxide results in increased expression of PRDM1 mRNA CTD PMID:33098963 NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488 		JBrowse link
G Prdx3 peroxiredoxin 3 increases expression ISO Zinc Oxide results in increased expression of PRDX3 mRNA CTD PMID:19755143 NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111 		JBrowse link
G Prl prolactin decreases expression EXP Zinc Oxide results in decreased expression of PRL protein CTD PMID:33205376 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Prnp prion protein increases expression ISO Zinc Oxide results in increased expression of PRNP mRNA CTD PMID:19755143 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937 		JBrowse link
G Ptch1 patched 1 increases expression ISO Zinc Oxide results in increased expression of PTCH1 mRNA CTD PMID:33236829 NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO Zinc Oxide affects the splicing of and results in increased expression of PTGS1 mRNA CTD PMID:30500950 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 ISO Zinc Oxide analog results in increased expression of PTGS2 protein; Zinc Oxide results in increased expression of PTGS2 protein
Zinc Oxide affects the splicing of and affects the expression of PTGS2 mRNA; Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of PTGS2 protein]		 CTD PMID:24368203 PMID:25127755 PMID:30500950 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO [RAC1 protein binds to CDC42 protein] affects the reaction [Zinc Oxide results in increased expression of ICAM1 protein]; NSC 23766 inhibits the reaction [Zinc Oxide results in increased activity of and results in increased phosphorylation of [RAC1 protein binds to CDC42 protein]]; Zinc Oxide results in increased activity of and results in increased phosphorylation of [RAC1 protein binds to CDC42 protein] CTD PMID:22166487 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Rad51 RAD51 recombinase multiple interactions ISO Zinc Oxide affects the splicing of and results in increased expression of RAD51 mRNA CTD PMID:30500950 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G Rbp4 retinol binding protein 4 affects expression EXP Zinc Oxide affects the expression of RBP4 protein CTD PMID:33205376 NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases phosphorylation
multiple interactions		 ISO Zinc Oxide results in increased phosphorylation of RELA protein
[Zinc Oxide results in increased phosphorylation of RELA protein] promotes the reaction [RELA protein binds to CXCL8 promoter]; Zinc Oxide promotes the reaction [RELA protein binds to CXCL8 promoter]		 CTD PMID:20194077 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 increases expression ISO Zinc Oxide results in increased expression of RIPK1 mRNA CTD PMID:32600046 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 multiple interactions ISO Zinc Oxide affects the splicing of and results in increased expression of RIPK2 mRNA CTD PMID:30500950 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657 		JBrowse link
G Serpine1 serpin family E member 1 decreases expression EXP Zinc Oxide results in decreased expression of SERPINE1 protein CTD PMID:33205376 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Slc11a2 solute carrier family 11 member 2 multiple interactions ISO Zinc Oxide affects the splicing of and results in decreased expression of SLC11A2 mRNA CTD PMID:30500950 NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145 		JBrowse link
G Slc12a1 solute carrier family 12 member 1 decreases expression ISO Zinc Oxide analog results in decreased expression of SLC12A1 mRNA CTD PMID:27185063 NCBI chr 3:112,406,140...112,482,913
Ensembl chr 3:112,406,140...112,482,899 		JBrowse link
G Slc30a1 solute carrier family 30 member 1 increases expression ISO Zinc Oxide results in increased expression of SLC30A1 mRNA CTD PMID:29289694 PMID:33599401 NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910 		JBrowse link
G Smo smoothened, frizzled class receptor increases expression ISO Zinc Oxide results in increased expression of SMO mRNA CTD PMID:33236829 NCBI chr 4:58,344,101...58,372,828
Ensembl chr 4:58,343,529...58,373,829 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO Zinc Oxide results in increased expression of SOD1 mRNA CTD PMID:32600046 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO Zinc Oxide results in increased expression of SOD2 mRNA CTD PMID:32600046 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression EXP Zinc Oxide results in decreased expression of SPP1 protein CTD PMID:33205376 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO Zinc Oxide results in increased expression of SQSTM1 protein CTD PMID:29289694 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Srxn1 sulfiredoxin 1 multiple interactions ISO Zinc Oxide affects the splicing of and results in increased expression of SRXN1 mRNA CTD PMID:30500950 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448 		JBrowse link
G Star steroidogenic acute regulatory protein decreases expression ISO Zinc Oxide results in decreased expression of STAR mRNA CTD PMID:33236829 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression ISO Zinc Oxide analog results in decreased expression of STAT1 mRNA CTD PMID:27185063 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Stra8 stimulated by retinoic acid 8 decreases expression ISO Zinc Oxide results in decreased expression of STRA8 mRNA CTD PMID:33098963 NCBI chr 4:63,601,443...63,624,777
Ensembl chr 4:63,601,604...63,624,771 		JBrowse link
G Syk spleen associated tyrosine kinase multiple interactions ISO [Zinc Oxide analog co-treated with OVAL protein] results in increased phosphorylation of SYK protein CTD PMID:25127755 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410 		JBrowse link
G Tert telomerase reverse transcriptase increases expression ISO Zinc Oxide results in increased expression of TERT mRNA CTD PMID:33098963 NCBI chr 1:29,637,213...29,659,509
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Tlr1 toll-like receptor 1 multiple interactions ISO Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of TLR1 mRNA] CTD PMID:25127755 NCBI chr14:43,384,127...43,396,765
Ensembl chr14:43,384,932...43,397,125 		JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO [Zinc Oxide analog co-treated with OVAL protein] results in increased expression of TLR2 protein; Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of TLR2 mRNA] CTD PMID:25127755 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO [Zinc Oxide analog co-treated with OVAL protein] results in increased expression of TLR4 protein; Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of TLR4 mRNA] CTD PMID:25127755 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tlr6 toll-like receptor 6 multiple interactions
increases expression		 ISO [Zinc Oxide analog co-treated with OVAL protein] results in increased expression of TLR6 protein; Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of TLR6 mRNA]
Zinc Oxide analog results in increased expression of TLR6 mRNA		 CTD PMID:25127755 NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
decreases expression		 ISO
EXP		 Zinc Oxide analog results in increased expression of TNF mRNA; Zinc Oxide results in increased expression of TNF protein
MYD88 mutant form inhibits the reaction [Zinc Oxide analog results in increased expression of TNF mRNA]
lead acetate promotes the reaction [Zinc Oxide results in increased expression of TNF protein]; Zinc Oxide inhibits the reaction [Dimethylnitrosamine results in increased expression of TNF protein]; Zinc Oxide promotes the reaction [lead acetate results in increased expression of TNF protein]
Zinc Oxide results in decreased expression of TNF protein		 CTD PMID:23352990 PMID:24368203 PMID:29024620 PMID:33205376 PMID:34553816 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 ISO Zinc Oxide results in increased phosphorylation of and results in increased expression of TP53 protein
Zinc Oxide analog results in increased expression of TRP53 protein		 CTD PMID:21903158 PMID:24614525 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO [Zinc Oxide analog co-treated with OVAL protein] results in increased expression of TRAF6 protein; Zinc Oxide affects the splicing of and results in increased expression of TRAF6 mRNA CTD PMID:25127755 PMID:30500950 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions
decreases secretion		 EXP lead acetate promotes the reaction [Zinc Oxide results in decreased secretion of TSHB protein]; Zinc Oxide promotes the reaction [lead acetate results in decreased secretion of TSHB protein] CTD PMID:34553816 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression
multiple interactions		 ISO Zinc Oxide results in increased expression of TXNRD1 mRNA
Zinc Oxide affects the splicing of and affects the expression of TXNRD1 mRNA		 CTD PMID:19755143 PMID:30500950 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 increases expression ISO Zinc Oxide results in increased expression of VDAC1 mRNA CTD PMID:33236829 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640 		JBrowse link
G Xbp1 X-box binding protein 1 increases expression ISO Zinc Oxide analog results in increased expression of XBP1 mRNA CTD PMID:25680694 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
G Zfp36 zinc finger protein 36 increases expression ISO Zinc Oxide results in increased expression of ZFP36 protein CTD PMID:21769377 NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20057
    chemical entity 20068
      molecular entity 20056
        transition element molecular entity 16699
          d-block molecular entity 16692
            zinc group molecular entity 10776
              zinc molecular entity 2800
                zinc oxide 161
                  zinc oxide nanoparticle 0
                  zinc oxide nanorod 0
                  zinc oxide nanotube 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20057
    subatomic particle 20056
      composite particle 20068
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  metal atom 17605
                    transition element atom 16993
                      d-block element atom 16984
                        zinc group element atom 11233
                          zinc atom 2800
                            zinc molecular entity 2800
                              zinc oxide 161
                                zinc oxide nanoparticle 0
                                zinc oxide nanorod 0
                                zinc oxide nanotube 0
paths to the root