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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chlorzoxazone
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Accession:CHEBI:3655 term browser browse the term
Definition:A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazol-2-ol in which the hydrogen atom at position 5 is substituted by chlorine. A centrally acting muscle relaxant with sedative properties, it is used for the symptomatic treatment of painful muscle spasm.
Synonyms:exact_synonym: 5-chloro-1,3-benzoxazol-2-ol
 related_synonym: 2-hydroxy-5-chlorobenzoxazole;   5-chloro-2(3H)-benzoxazolone;   5-chloro-2-benzoxazolinone;   5-chloro-2-benzoxazolol;   5-chloro-2-benzoxazolone;   5-chloro-2-hydroxybenzoxazole;   5-chlorobenzoxazolidone;   5-chlorobenzoxazolin-2-one;   Formula=C7H4ClNO2;   InChI=1S/C7H4ClNO2/c8-4-1-2-6-5(3-4)9-7(10)11-6/h1-3H,(H,9,10);   InChIKey=TZFWDZFKRBELIQ-UHFFFAOYSA-N;   SMILES=Oc1nc2cc(Cl)ccc2o1;   chlorzoxane;   chlorzoxazona;   chlorzoxazonum
 alt_id: CHEBI:47330
 xref: Beilstein:638882;   CAS:95-25-0;   DrugBank:DB00356;   Drug_Central:626;   HMDB:HMDB0014500;   KEGG:C07931;   KEGG:D00771;   LINCS:LSM-6011
 xref_mesh: MESH:D002753
 xref: PDBeChem:CLW;   PMID:10640318;   PMID:11727787;   PMID:12437348;   PMID:16763012;   PMID:16859676;   PMID:17621748;   PMID:21195386;   PMID:23975871;   PMID:24210069;   PMID:25815637;   PMID:6631711;   Patent:US2895877;   Reaxys:638882;   Wikipedia:Chlorzoxazone


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chlorzoxazone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyb5a cytochrome b5 type A multiple interactions ISO CYB5A protein promotes the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone] CTD PMID:15728263 NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 affects metabolic processing EXP CYP1A1 protein affects the metabolism of Chlorzoxazone CTD PMID:15231049 PMID:15879494 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing
increases hydroxylation
ISO
EXP
CYP1A2 protein affects the metabolism of Chlorzoxazone
CYP1A2 protein results in increased hydroxylation of Chlorzoxazone
CTD PMID:11911841 PMID:14586387 PMID:15879494 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 affects metabolic processing EXP CYP2B1 protein affects the metabolism of Chlorzoxazone CTD PMID:15879494 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 affects metabolic processing EXP CYP2C11 protein affects the metabolism of Chlorzoxazone CTD PMID:15879494 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 affects metabolic processing EXP CYP2C13 protein affects the metabolism of Chlorzoxazone CTD PMID:15879494 NCBI chr 1:238,786,764...238,867,195
Ensembl chr 1:238,786,765...238,867,191
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 affects metabolic processing EXP CYP2C6V1 protein affects the metabolism of Chlorzoxazone CTD PMID:15879494 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects hydroxylation
increases metabolic processing
increases hydroxylation
multiple interactions
affects metabolic processing
increases oxidation
ISO
EXP
CYP2E1 protein affects the hydroxylation of Chlorzoxazone
CYP2E1 protein results in increased metabolism of Chlorzoxazone
CYP2E1 protein results in increased hydroxylation of Chlorzoxazone
[CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased abundance of 6-hydroxychlorzoxazone; [CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone; Resveratrol inhibits the reaction [CYP2E1 protein results in increased metabolism of Chlorzoxazone]
CYP2E1 mRNA results in increased metabolism of Chlorzoxazone; CYP2E1 protein results in increased metabolism of Chlorzoxazone
CYP2E1 protein affects the metabolism of Chlorzoxazone
[CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone; Imidazoles inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; Isoquinolines inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; Pyridines inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; Quinolines inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]
CYP2E1 protein results in increased oxidation of Chlorzoxazone
[5-bromotryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [5-chlorotryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [5-fluoro-alpha-methyltryptamine results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [5-fluorotryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [5-methyltryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [7-methyltryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [Chlormethiazole results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [Chlorzoxazone results in decreased activity of CYP2E1 protein] which results in decreased degradation of vanoxerine; [CYP2E1 mRNA results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone; [CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone; [indopan analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [indopan results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [Methoxydimethyltryptamines analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [N,N-diisopropyltryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [Tryptamines analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; Carbaryl inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; chlorfluazuron inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; Chlorpyrifos inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; CYB5A protein promotes the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; cypermethrin inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; Disulfiram inhibits the reaction [[CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone]; Disulfiram inhibits the reaction [CYP2E1 protein results in increased metabolism of Chlorzoxazone]; Fenitrothion inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; fenvalerate inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; Fomepizole inhibits the reaction [CYP2E1 protein results in increased metabolism of Chlorzoxazone]; isoproturon inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; Malathion inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; perfluorooctane sulfonic acid inhibits the reaction [CYP2E1 protein results in increased oxidation of Chlorzoxazone]; phenthoate inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; profenofos inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]
CTD PMID:7747284 PMID:8558417 PMID:8858968 PMID:9817075 PMID:9825833 More... NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing EXP CYP3A2 protein affects the metabolism of Chlorzoxazone CTD PMID:15879494 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases hydroxylation
affects metabolic processing
EXP CYP3A23-3A1 protein results in increased hydroxylation of Chlorzoxazone
CYP3A23-3A1 protein affects the metabolism of Chlorzoxazone
CTD PMID:11911841 PMID:15879494 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects metabolic processing EXP CYP3A9 protein affects the metabolism of Chlorzoxazone CTD PMID:15879494 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Ins2 insulin 2 multiple interactions ISO INS protein inhibits the reaction [stearic acid results in increased hydroxylation of Chlorzoxazone] CTD PMID:26739624 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 increases activity ISO Chlorzoxazone results in increased activity of KCNN4 protein CTD PMID:14985237 NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340
JBrowse link
G Nat2 N-acetyltransferase 2 affects metabolic processing ISO NAT2 protein affects the metabolism of Chlorzoxazone CTD PMID:14586387 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
JBrowse link
G Xdh xanthine dehydrogenase affects metabolic processing ISO XDH protein affects the metabolism of Chlorzoxazone CTD PMID:14586387 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link

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  CHEBI ontology 19821
    role 19769
      application 19481
        pharmaceutical 19329
          drug 19329
            neuromuscular agent 1309
              muscle relaxant 1304
                chlorzoxazone 15
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  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic molecule 19569
                              organic cyclic compound 19360
                                organic heterocyclic compound 18591
                                  organic heteropolycyclic compound 18064
                                    organic heterobicyclic compound 16868
                                      benzoxazole 115
                                        1,3-benzoxazoles 43
                                          chlorzoxazone 15
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