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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chlorzoxazone
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Accession:CHEBI:3655 term browser browse the term
Definition:A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazol-2-ol in which the hydrogen atom at position 5 is substituted by chlorine. A centrally acting muscle relaxant with sedative properties, it is used for the symptomatic treatment of painful muscle spasm.
Synonyms:exact_synonym: 5-chloro-1,3-benzoxazol-2-ol
 related_synonym: 2-hydroxy-5-chlorobenzoxazole;   5-chloro-2(3H)-benzoxazolone;   5-chloro-2-benzoxazolinone;   5-chloro-2-benzoxazolol;   5-chloro-2-benzoxazolone;   5-chloro-2-hydroxybenzoxazole;   5-chlorobenzoxazolidone;   5-chlorobenzoxazolin-2-one;   Formula=C7H4ClNO2;   InChI=1S/C7H4ClNO2/c8-4-1-2-6-5(3-4)9-7(10)11-6/h1-3H,(H,9,10);   InChIKey=TZFWDZFKRBELIQ-UHFFFAOYSA-N;   SMILES=Oc1nc2cc(Cl)ccc2o1;   chlorzoxane;   chlorzoxazona;   chlorzoxazonum
 alt_id: CHEBI:47330
 xref: Beilstein:638882;   CAS:95-25-0;   DrugBank:DB00356;   Drug_Central:626;   HMDB:HMDB0014500;   KEGG:C07931;   KEGG:D00771;   LINCS:LSM-6011
 xref_mesh: MESH:D002753
 xref: PDBeChem:CLW;   PMID:10640318;   PMID:11727787;   PMID:12437348;   PMID:16763012;   PMID:16859676;   PMID:17621748;   PMID:21195386;   PMID:23975871;   PMID:24210069;   PMID:25815637;   PMID:6631711;   Patent:US2895877;   Reaxys:638882;   Wikipedia:Chlorzoxazone


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chlorzoxazone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyb5a cytochrome b5 type A multiple interactions ISO CYB5A protein promotes the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone] CTD PMID:15728263 NCBI chr18:81,694,818...81,726,821
Ensembl chr18:81,694,808...81,726,821
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 affects metabolic processing EXP CYP1A1 protein affects the metabolism of Chlorzoxazone CTD PMID:15231049, PMID:15879494 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing
increases hydroxylation
ISO
EXP
CYP1A2 protein affects the metabolism of Chlorzoxazone
CYP1A2 protein results in increased hydroxylation of Chlorzoxazone
CTD PMID:11911841, PMID:14586387, PMID:15879494 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 affects metabolic processing EXP CYP2B1 protein affects the metabolism of Chlorzoxazone CTD PMID:15879494 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 affects metabolic processing EXP CYP2C11 protein affects the metabolism of Chlorzoxazone CTD PMID:15879494 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 affects metabolic processing EXP CYP2C13 protein affects the metabolism of Chlorzoxazone CTD PMID:15879494 NCBI chr 1:258,796,624...258,877,023
Ensembl chr 1:258,796,622...258,877,045
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 affects metabolic processing EXP CYP2C6V1 protein affects the metabolism of Chlorzoxazone CTD PMID:15879494 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects hydroxylation
increases metabolic processing
increases hydroxylation
multiple interactions
affects metabolic processing
increases oxidation
ISO
EXP
CYP2E1 protein affects the hydroxylation of Chlorzoxazone
CYP2E1 protein results in increased metabolism of Chlorzoxazone
CYP2E1 protein results in increased hydroxylation of Chlorzoxazone
[CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased abundance of 6-hydroxychlorzoxazone; [CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone; Resveratrol inhibits the reaction [CYP2E1 protein results in increased metabolism of Chlorzoxazone]
CYP2E1 mRNA results in increased metabolism of Chlorzoxazone; CYP2E1 protein results in increased metabolism of Chlorzoxazone
CYP2E1 protein affects the metabolism of Chlorzoxazone
[CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone; Imidazoles inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; Isoquinolines inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; Pyridines inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; Quinolines inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]
CYP2E1 protein results in increased oxidation of Chlorzoxazone
[5-bromotryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [5-chlorotryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [5-fluoro-alpha-methyltryptamine results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [5-fluorotryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [5-methyltryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [7-methyltryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [Chlormethiazole results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [Chlorzoxazone results in decreased activity of CYP2E1 protein] which results in decreased degradation of vanoxerine; [CYP2E1 mRNA results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone; [CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone; [indopan analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [indopan results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [Methoxydimethyltryptamines analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [N,N-diisopropyltryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [Tryptamines analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; Carbaryl inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; chlorfluazuron inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; Chlorpyrifos inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; CYB5A protein promotes the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; cypermethrin inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; Disulfiram inhibits the reaction [[CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone]; Disulfiram inhibits the reaction [CYP2E1 protein results in increased metabolism of Chlorzoxazone]; Fenitrothion inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; fenvalerate inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; Fomepizole inhibits the reaction [CYP2E1 protein results in increased metabolism of Chlorzoxazone]; isoproturon inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; Malathion inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; perfluorooctane sulfonic acid inhibits the reaction [CYP2E1 protein results in increased oxidation of Chlorzoxazone]; phenthoate inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; profenofos inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]
CTD PMID:7747284, PMID:8558417, PMID:8858968, PMID:9817075, PMID:9825833, PMID:10207612, PMID:10463382, PMID:11502731, PMID:11911841, PMID:12401345, PMID:12433797, PMID:12464242, PMID:12690492, PMID:12818727, PMID:14586387, PMID:15155557, PMID:15205388, PMID:15231049, PMID:15255802, PMID:15327588, PMID:15370959, PMID:15576447, PMID:15618748, PMID:15626586, PMID:15728263, PMID:15802389, PMID:15879494, PMID:16124035, PMID:17565714, PMID:21600194, PMID:21915887, PMID:21964418, PMID:22634058, PMID:23669205, PMID:25956474, PMID:26599973, PMID:26739624, PMID:28438436, PMID:28762043, PMID:29555536, PMID:30503582, PMID:31501917 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing EXP CYP3A2 protein affects the metabolism of Chlorzoxazone CTD PMID:15879494 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases hydroxylation
affects metabolic processing
EXP CYP3A23-3A1 protein results in increased hydroxylation of Chlorzoxazone
CYP3A23-3A1 protein affects the metabolism of Chlorzoxazone
CTD PMID:11911841, PMID:15879494 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects metabolic processing EXP CYP3A9 protein affects the metabolism of Chlorzoxazone CTD PMID:15879494 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Ins2 insulin 2 multiple interactions ISO INS protein inhibits the reaction [stearic acid results in increased hydroxylation of Chlorzoxazone] CTD PMID:26739624 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 increases activity ISO Chlorzoxazone results in increased activity of KCNN4 protein CTD PMID:14985237 NCBI chr 1:81,227,855...81,245,986
Ensembl chr 1:81,230,612...81,245,996
JBrowse link
G Nat2 N-acetyltransferase 2 affects metabolic processing ISO NAT2 protein affects the metabolism of Chlorzoxazone CTD PMID:14586387 NCBI chr16:23,960,709...23,991,570
Ensembl chr16:23,961,067...23,991,570
JBrowse link
G Xdh xanthine dehydrogenase affects metabolic processing ISO XDH protein affects the metabolism of Chlorzoxazone CTD PMID:14586387 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        pharmaceutical 19272
          drug 19272
            neuromuscular agent 1291
              muscle relaxant 1286
                chlorzoxazone 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic heterocyclic compound 18407
                                  organic heteropolycyclic compound 17820
                                    organic heterobicyclic compound 16742
                                      benzoxazole 112
                                        1,3-benzoxazoles 41
                                          chlorzoxazone 15
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