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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:chlorthalidone
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Accession:CHEBI:3654 term browser browse the term
Definition:An isoindole that has formula C14H11ClN2O4S.
Synonyms:related_synonym: 1-keto-3-(3'-sulfamyl-4'-chlorophenyl)-3-hydroxyisoindoline;   1-oxo-3-(3-sulfamyl-4-chlorophenyl)-3-hydroxyisoindoline;   2-chloro-5-(1-hydroxy-3-oxo-1-isoindolinyl)benzenesulfonamide;   2-chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)benzenesulfonamide;   3-(4'-chloro-3'-sulfamoylphenyl)-3-hydroxyphthalimidine;   3-hydroxy-3-(4-chloro-3-sulfamylphenyl)phthalimidine;   Chlortalidone;   Formula=C14H11ClN2O4S;   InChI=1S/C14H11ClN2O4S/c15-11-6-5-8(7-12(11)22(16,20)21)14(19)10-4-2-1-3-9(10)13(18)17-14/h1-7,19H,(H,17,18)(H2,16,20,21);   InChIKey=JIVPVXMEBJLZRO-UHFFFAOYSA-N;   SMILES=NS(=O)(=O)c1cc(ccc1Cl)C1(O)NC(=O)c2ccccc12;   chlorphthalidolone;   phthalamodine;   phthalamudine
 xref: Beilstein:312295;   CAS:77-36-1;   DrugBank:DB00310;   Drug_Central:625;   KEGG:D00272;   LINCS:LSM-1417
 xref_mesh: MESH:D002752
 xref: Wikipedia:Chlorthalidone


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chlorthalidone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgfr3 fibroblast growth factor receptor 3 decreases expression EXP Chlorthalidone results in decreased expression of FGFR3 mRNA CTD PMID:20625077 NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341 		JBrowse link
G Nrp2 neuropilin 2 decreases expression EXP Chlorthalidone results in decreased expression of NRP2 mRNA CTD PMID:20625077 NCBI chr 9:64,122,815...64,238,007
Ensembl chr 9:64,123,132...64,237,958 		JBrowse link
G Ren renin increases expression
increases activity		 ISO Chlorthalidone results in increased expression of REN protein modified form
Chlorthalidone results in increased activity of REN protein		 CTD PMID:796642 PMID:1116335 PMID:3319646 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 decreases expression EXP Chlorthalidone results in decreased expression of TGFB3 mRNA CTD PMID:20625077 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564 		JBrowse link
G Vegfc vascular endothelial growth factor C decreases expression
increases expression		 EXP Chlorthalidone results in decreased expression of VEGFC mRNA; Chlorthalidone results in decreased expression of VEGFC protein
Chlorthalidone results in increased expression of VEGFC protein		 CTD PMID:20625077 NCBI chr16:37,712,408...37,827,657
Ensembl chr16:37,712,262...37,827,848 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    chemical entity 19810
      atom 19810
        nonmetal atom 19744
          sulfur atom 17565
            sulfur molecular entity 17565
              organosulfur compound 17194
                sulfonamide 3229
                  chlorthalidone 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19810
      composite particle 19810
        hadron 19810
          baryon 19810
            nucleon 19810
              atomic nucleus 19810
                atom 19810
                  main group element atom 19755
                    p-block element atom 19755
                      carbon group element atom 19698
                        carbon atom 19693
                          organic molecular entity 19693
                            organic molecule 19651
                              organic cyclic compound 19457
                                organic heterocyclic compound 18816
                                  organic heteropolycyclic compound 18296
                                    organic heterobicyclic compound 17245
                                      benzopyrrole 9622
                                        isoindoles 1146
                                          chlorthalidone 5
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