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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chlorthalidone
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Accession:CHEBI:3654 term browser browse the term
Definition:An isoindole that has formula C14H11ClN2O4S.
Synonyms:related_synonym: 1-keto-3-(3'-sulfamyl-4'-chlorophenyl)-3-hydroxyisoindoline;   1-oxo-3-(3-sulfamyl-4-chlorophenyl)-3-hydroxyisoindoline;   2-chloro-5-(1-hydroxy-3-oxo-1-isoindolinyl)benzenesulfonamide;   2-chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)benzenesulfonamide;   3-(4'-chloro-3'-sulfamoylphenyl)-3-hydroxyphthalimidine;   3-hydroxy-3-(4-chloro-3-sulfamylphenyl)phthalimidine;   Chlortalidone;   Formula=C14H11ClN2O4S;   InChI=1S/C14H11ClN2O4S/c15-11-6-5-8(7-12(11)22(16,20)21)14(19)10-4-2-1-3-9(10)13(18)17-14/h1-7,19H,(H,17,18)(H2,16,20,21);   InChIKey=JIVPVXMEBJLZRO-UHFFFAOYSA-N;   SMILES=NS(=O)(=O)c1cc(ccc1Cl)C1(O)NC(=O)c2ccccc12;   chlorphthalidolone;   phthalamodine;   phthalamudine
 xref: Beilstein:312295;   CAS:77-36-1;   DrugBank:DB00310;   Drug_Central:625;   KEGG:D00272;   LINCS:LSM-1417
 xref_mesh: MESH:D002752
 xref: Wikipedia:Chlorthalidone


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chlorthalidone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgfr3 fibroblast growth factor receptor 3 decreases expression EXP Chlorthalidone results in decreased expression of FGFR3 mRNA CTD PMID:20625077 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706
JBrowse link
G Nrp2 neuropilin 2 decreases expression EXP Chlorthalidone results in decreased expression of NRP2 mRNA CTD PMID:20625077 NCBI chr 9:69,496,875...69,609,802
Ensembl chr 9:69,497,121...69,612,087
JBrowse link
G Ren renin increases expression
increases activity
ISO Chlorthalidone results in increased expression of REN protein modified form
Chlorthalidone results in increased activity of REN protein
CTD PMID:796642, PMID:1116335, PMID:3319646 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Tgfb3 transforming growth factor, beta 3 decreases expression EXP Chlorthalidone results in decreased expression of TGFB3 mRNA CTD PMID:20625077 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533
JBrowse link
G Vegfc vascular endothelial growth factor C decreases expression
increases expression
EXP Chlorthalidone results in decreased expression of VEGFC mRNA; Chlorthalidone results in decreased expression of VEGFC protein
Chlorthalidone results in increased expression of VEGFC protein
CTD PMID:20625077 NCBI chr16:40,440,371...40,555,178
Ensembl chr16:40,440,207...40,555,576
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    chemical entity 19787
      atom 19784
        nonmetal atom 19659
          sulfur atom 16256
            sulfur molecular entity 16256
              organosulfur compound 15190
                sulfonamide 3168
                  chlorthalidone 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  organic heteropolycyclic compound 17824
                                    organic heterobicyclic compound 16744
                                      benzopyrrole 9340
                                        isoindoles 544
                                          chlorthalidone 5
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