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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chlorthalidone
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Accession:CHEBI:3654 term browser browse the term
Definition:An isoindole that has formula C14H11ClN2O4S.
Synonyms:related_synonym: 1-keto-3-(3'-sulfamyl-4'-chlorophenyl)-3-hydroxyisoindoline;   1-oxo-3-(3-sulfamyl-4-chlorophenyl)-3-hydroxyisoindoline;   2-chloro-5-(1-hydroxy-3-oxo-1-isoindolinyl)benzenesulfonamide;   2-chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)benzenesulfonamide;   3-(4'-chloro-3'-sulfamoylphenyl)-3-hydroxyphthalimidine;   3-hydroxy-3-(4-chloro-3-sulfamylphenyl)phthalimidine;   Chlortalidone;   Formula=C14H11ClN2O4S;   InChI=1S/C14H11ClN2O4S/c15-11-6-5-8(7-12(11)22(16,20)21)14(19)10-4-2-1-3-9(10)13(18)17-14/h1-7,19H,(H,17,18)(H2,16,20,21);   InChIKey=JIVPVXMEBJLZRO-UHFFFAOYSA-N;   SMILES=NS(=O)(=O)c1cc(ccc1Cl)C1(O)NC(=O)c2ccccc12;   chlorphthalidolone;   phthalamodine;   phthalamudine
 xref: Beilstein:312295;   CAS:77-36-1;   DrugBank:DB00310;   Drug_Central:625;   KEGG:D00272;   LINCS:LSM-1417
 xref_mesh: MESH:D002752
 xref: Wikipedia:Chlorthalidone


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chlorthalidone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgfr3 fibroblast growth factor receptor 3 decreases expression EXP Chlorthalidone results in decreased expression of FGFR3 mRNA CTD PMID:20625077 NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341
JBrowse link
G Nrp2 neuropilin 2 decreases expression EXP Chlorthalidone results in decreased expression of NRP2 mRNA CTD PMID:20625077 NCBI chr 9:64,122,815...64,238,007
Ensembl chr 9:64,123,132...64,237,958
JBrowse link
G Ren renin increases expression
increases activity
ISO Chlorthalidone results in increased expression of REN protein modified form
Chlorthalidone results in increased activity of REN protein
CTD PMID:796642 PMID:1116335 PMID:3319646 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Tgfb3 transforming growth factor, beta 3 decreases expression EXP Chlorthalidone results in decreased expression of TGFB3 mRNA CTD PMID:20625077 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564
JBrowse link
G Vegfc vascular endothelial growth factor C decreases expression
increases expression
EXP Chlorthalidone results in decreased expression of VEGFC mRNA; Chlorthalidone results in decreased expression of VEGFC protein
Chlorthalidone results in increased expression of VEGFC protein
CTD PMID:20625077 NCBI chr16:37,712,408...37,827,657
Ensembl chr16:37,712,262...37,827,848
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    chemical entity 19812
      atom 19811
        nonmetal atom 19698
          sulfur atom 16395
            sulfur molecular entity 16395
              organosulfur compound 15272
                sulfonamide 3193
                  chlorthalidone 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic molecule 19560
                              organic cyclic compound 19351
                                organic heterocyclic compound 18582
                                  organic heteropolycyclic compound 18059
                                    organic heterobicyclic compound 16869
                                      benzopyrrole 9559
                                        isoindoles 1127
                                          chlorthalidone 5
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