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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chlorprothixene
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Accession:CHEBI:3651 term browser browse the term
Definition:A thioxanthene that has formula C18H18ClNS.
Synonyms:exact_synonym: 3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dimethylpropan-1-amine
 related_synonym: Alpha-Chlorprothixene;   Chlorprothixen;   Chlorprothixine;   Chlorprotixen;   Chlorprotixene;   Chlorprotixine;   Chlothixen;   Formula=C18H18ClNS;   InChI=1S/C18H18ClNS/c1-20(2)11-5-7-14-15-6-3-4-8-17(15)21-18-10-9-13(19)12-16(14)18/h3-4,6-10,12H,5,11H2,1-2H3;   InChIKey=WSPOMRSOLSGNFJ-UHFFFAOYSA-N;   SMILES=[H]C(CCN(C)C)=C1c2ccccc2Sc2ccc(Cl)cc12;   chlorprothixenum;   clorprotixeno
 xref: Beilstein:89898;   CAS:113-59-7;   DrugBank:DB01239;   KEGG:C07953;   KEGG:D00790;   LINCS:LSM-3310
 xref_mesh: MESH:D002749
 xref: Patent:GB829763;   Patent:US3046283


show annotations for term's descendants           Sort by:
 
chlorprothixene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions ISO Chlorprothixene inhibits the reaction [(2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane binds to HTR1A protein] CTD PMID:2891550 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Chlorprothixene results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Prl prolactin increases secretion ISO Chlorprothixene results in increased secretion of PRL protein CTD PMID:10525070 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
(Z)-chlorprothixene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions ISO Chlorprothixene inhibits the reaction [(2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane binds to HTR1A protein] CTD PMID:2891550 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Chlorprothixene results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Prl prolactin increases secretion ISO Chlorprothixene results in increased secretion of PRL protein CTD PMID:10525070 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        pharmacological role 18797
          analgesic 13063
            non-narcotic analgesic 11982
              chlorprothixene 3
                (Z)-chlorprothixene 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            inorganic hydride 17411
                              pnictogen hydride 17383
                                nitrogen hydride 17224
                                  azane 16941
                                    ammonia 16940
                                      organic amino compound 16939
                                        tertiary amino compound 8630
                                          tertiary amine 616
                                            chlorprothixene 3
                                              (Z)-chlorprothixene 3
paths to the root

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