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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:chlorprothixene
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Accession:CHEBI:3651 term browser browse the term
Definition:A thioxanthene that has formula C18H18ClNS.
Synonyms:exact_synonym: 3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dimethylpropan-1-amine
 related_synonym: Alpha-Chlorprothixene;   Chlorprothixen;   Chlorprothixine;   Chlorprotixen;   Chlorprotixene;   Chlorprotixine;   Chlothixen;   Formula=C18H18ClNS;   InChI=1S/C18H18ClNS/c1-20(2)11-5-7-14-15-6-3-4-8-17(15)21-18-10-9-13(19)12-16(14)18/h3-4,6-10,12H,5,11H2,1-2H3;   InChIKey=WSPOMRSOLSGNFJ-UHFFFAOYSA-N;   SMILES=[H]C(CCN(C)C)=C1c2ccccc2Sc2ccc(Cl)cc12;   chlorprothixenum;   clorprotixeno
 xref: Beilstein:89898;   DrugBank:DB01239;   HMDB:HMDB0015369;   KEGG:C07953;   KEGG:D00790;   LINCS:LSM-3310
 xref_mesh: MESH:D002749
 xref: Patent:GB829763;   Patent:US3046283
 cyclic_relationship: is_conjugate_base_of CHEBI:180503


show annotations for term's descendants           Sort by:
(Z)-chlorprothixene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions ISO Chlorprothixene inhibits the reaction [(2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane binds to HTR1A protein] CTD PMID:2891550 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Chlorprothixene results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Prl prolactin increases secretion ISO Chlorprothixene results in increased secretion of PRL protein CTD PMID:10525070 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19886
      biological role 19884
        pharmacological role 19103
          analgesic 14752
            non-narcotic analgesic 13920
              chlorprothixene 3
                (E)-chlorprothixene 0
                (Z)-chlorprothixene 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19909
          baryon 19909
            nucleon 19909
              atomic nucleus 19909
                atom 19909
                  main group element atom 19856
                    main group molecular entity 19856
                      s-block molecular entity 19687
                        hydrogen molecular entity 19676
                          hydrides 19153
                            inorganic hydride 18131
                              pnictogen hydride 18120
                                nitrogen hydride 18026
                                  azane 17825
                                    ammonia 17824
                                      organic amino compound 17824
                                        tertiary amino compound 10136
                                          chlorprothixene 3
                                            (E)-chlorprothixene 0
                                            (Z)-chlorprothixene 3
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