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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:17beta-estradiol 3-glucosiduronic acid
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Accession:CHEBI:36489 term browser browse the term
Definition:A steroid glucosiduronic acid that consists of 17beta-estradiol having a beta-glucuronyl residue attached at position 3 via a glycosidic linkage.
Synonyms:related_synonym: 17beta-Estradiol 3-(beta-D-glucuronide);   17beta-estradiol 3-glucuronide;   17beta-hydroxyestra-1,3,5(10)-trien-3-yl beta-D-glucopyranosiduronic acid;   Estradiol-3-glucuronide;   Formula=C24H32O8;   InChI=1S/C24H32O8/c1-24-9-8-14-13-5-3-12(10-11(13)2-4-15(14)16(24)6-7-17(24)25)31-23-20(28)18(26)19(27)21(32-23)22(29)30/h3,5,10,14-21,23,25-28H,2,4,6-9H2,1H3,(H,29,30)/t14-,15-,16+,17+,18+,19+,20-,21+,23-,24+/m1/s1;   InChIKey=MUOHJTRCBBDUOW-QXYWQCSFSA-N;   SMILES=O([C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)C(O)=O)O)O)O)C2=CC3=C([C@@]4([C@]([C@]5([C@@]([C@@H](O)CC5)(CC4)C)[H])(CC3)[H])[H])C=C2
 alt_id: CHEBI:23964;   CHEBI:4865
 xref: Beilstein:1302617;   CAS:15270-30-1;   KEGG:C05503;   LIPID_MAPS_instance:LMST05010007
 xref_mesh: MESH:C025482
 xref: PMID:10365435;   PMID:10784423;   PMID:11812141;   PMID:11878459;   PMID:15516735;   PMID:15537867;   PMID:17612196;   PMID:20417221;   Reaxys:5658104
 cyclic_relationship: is_conjugate_acid_of CHEBI:136641


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17beta-estradiol 3-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 decreases activity ISO estradiol-3-glucuronide results in decreased activity of ABCB11 protein CTD PMID:10869290 NCBI chr 2:69,238,282...69,342,616
Ensembl chr 2:69,238,282...69,342,616
JBrowse link
G Kl klotho multiple interactions
increases hydrolysis
EXP estradiol-3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]
KL protein results in increased hydrolysis of estradiol-3-glucuronide
CTD PMID:14701853 NCBI chr 5:150,952,607...150,993,817
Ensembl chr 5:150,952,607...150,993,817
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21552
    role 21530
      biological role 21528
        molecular messenger 18821
          hormone 18263
            sex hormone 18097
              estrogen 18005
                17beta-estradiol 9609
                  17beta-estradiol 3-glucosiduronic acid 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 21552
    subatomic particle 21537
      composite particle 21537
        hadron 21537
          baryon 21537
            nucleon 21537
              atomic nucleus 21537
                atom 21537
                  main group element atom 21442
                    p-block element atom 21442
                      carbon group element atom 21235
                        carbon atom 21133
                          organic molecular entity 21133
                            heteroorganic entity 20770
                              organochalcogen compound 19989
                                organooxygen compound 19910
                                  carbohydrates and carbohydrate derivatives 12807
                                    carbohydrate 12807
                                      carbohydrate derivative 12438
                                        glycosyl compound 11154
                                          glycoside 9385
                                            glycosiduronic acid 141
                                              glucosiduronic acid 141
                                                beta-D-glucosiduronic acid 44
                                                  17beta-estradiol 3-glucosiduronic acid 2
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