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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:17beta-estradiol 3-glucosiduronic acid
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Accession:CHEBI:36489 term browser browse the term
Definition:A steroid glucosiduronic acid that consists of 17beta-estradiol having a beta-glucuronyl residue attached at position 3 via a glycosidic linkage.
Synonyms:exact_synonym: 17beta-hydroxyestra-1,3,5(10)-trien-3-yl beta-D-glucopyranosiduronic acid
 related_synonym: 17beta-Estradiol 3-(beta-D-glucuronide);   17beta-estradiol 3-glucuronide;   Estradiol-3-glucuronide;   Formula=C24H32O8;   InChI=1S/C24H32O8/c1-24-9-8-14-13-5-3-12(10-11(13)2-4-15(14)16(24)6-7-17(24)25)31-23-20(28)18(26)19(27)21(32-23)22(29)30/h3,5,10,14-21,23,25-28H,2,4,6-9H2,1H3,(H,29,30)/t14-,15-,16+,17+,18+,19+,20-,21+,23-,24+/m1/s1;   InChIKey=MUOHJTRCBBDUOW-QXYWQCSFSA-N;   SMILES=O([C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)C(O)=O)O)O)O)C2=CC3=C([C@@]4([C@]([C@]5([C@@]([C@@H](O)CC5)(CC4)C)[H])(CC3)[H])[H])C=C2
 alt_id: CHEBI:23964;   CHEBI:4865
 xref: Beilstein:1302617;   CAS:15270-30-1;   KEGG:C05503;   LIPID_MAPS_instance:LMST05010007
 xref_mesh: MESH:C025482
 xref: PMID:10365435;   PMID:10784423;   PMID:11812141;   PMID:11878459;   PMID:15516735;   PMID:15537867;   PMID:17612196;   PMID:20417221;   Reaxys:5658104
 cyclic_relationship: is_conjugate_acid_of CHEBI:136641



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17beta-estradiol 3-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity EXP estradiol-3-glucuronide results in decreased activity of ABCB11 protein CTD PMID:10869290 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Kl Klotho multiple interactions
increases hydrolysis
ISO estradiol-3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]
KL protein results in increased hydrolysis of estradiol-3-glucuronide
CTD PMID:14701853 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      application 19498
        pharmaceutical 19356
          drug 19356
            protective agent 17739
              geroprotector 16520
                17beta-estradiol 9880
                  17beta-estradiol 3-glucosiduronic acid 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            heteroorganic entity 19278
                              organochalcogen compound 19052
                                organooxygen compound 18998
                                  carbohydrates and carbohydrate derivatives 12342
                                    carbohydrate 12342
                                      carbohydrate derivative 11946
                                        glycosyl compound 10983
                                          glycoside 9266
                                            glycosiduronic acid 156
                                              glucosiduronic acid 156
                                                beta-D-glucosiduronic acid 48
                                                  17beta-estradiol 3-glucosiduronic acid 2
paths to the root