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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:17beta-estradiol 3-glucosiduronic acid
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Accession:CHEBI:36489 term browser browse the term
Definition:A steroid glucosiduronic acid that consists of 17beta-estradiol having a beta-glucuronyl residue attached at position 3 via a glycosidic linkage.
Synonyms:related_synonym: 17beta-Estradiol 3-(beta-D-glucuronide);   17beta-estradiol 3-glucuronide;   17beta-hydroxyestra-1,3,5(10)-trien-3-yl beta-D-glucopyranosiduronic acid;   Estradiol-3-glucuronide;   Formula=C24H32O8;   InChI=1S/C24H32O8/c1-24-9-8-14-13-5-3-12(10-11(13)2-4-15(14)16(24)6-7-17(24)25)31-23-20(28)18(26)19(27)21(32-23)22(29)30/h3,5,10,14-21,23,25-28H,2,4,6-9H2,1H3,(H,29,30)/t14-,15-,16+,17+,18+,19+,20-,21+,23-,24+/m1/s1;   InChIKey=MUOHJTRCBBDUOW-QXYWQCSFSA-N;   SMILES=O([C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)C(O)=O)O)O)O)C2=CC3=C([C@@]4([C@]([C@]5([C@@]([C@@H](O)CC5)(CC4)C)[H])(CC3)[H])[H])C=C2
 alt_id: CHEBI:23964;   CHEBI:4865
 xref: Beilstein:1302617;   CAS:15270-30-1;   KEGG:C05503;   LIPID_MAPS_instance:LMST05010007
 xref_mesh: MESH:C025482
 xref: PMID:10365435;   PMID:10784423;   PMID:11812141;   PMID:11878459;   PMID:15516735;   PMID:15537867;   PMID:17612196;   PMID:20417221;   Reaxys:5658104
 cyclic_relationship: is_conjugate_acid_of CHEBI:136641


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17beta-estradiol 3-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity EXP estradiol-3-glucuronide results in decreased activity of ABCB11 protein CTD PMID:10869290 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Kl Klotho multiple interactions
increases hydrolysis
ISO estradiol-3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]
KL protein results in increased hydrolysis of estradiol-3-glucuronide
CTD PMID:14701853 NCBI chr12:942,974...987,206
Ensembl chr12:943,006...987,551
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      biological role 19716
        molecular messenger 18301
          hormone 18072
            sex hormone 17968
              estrogen 17912
                17beta-estradiol 9876
                  17beta-estradiol 3-glucosiduronic acid 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            heteroorganic entity 19199
                              organochalcogen compound 18946
                                organooxygen compound 18873
                                  carbohydrates and carbohydrate derivatives 12285
                                    carbohydrate 12285
                                      carbohydrate derivative 11893
                                        glycosyl compound 10967
                                          glycoside 9260
                                            glycosiduronic acid 149
                                              glucosiduronic acid 149
                                                beta-D-glucosiduronic acid 47
                                                  17beta-estradiol 3-glucosiduronic acid 2
paths to the root