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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:17beta-estradiol 3-glucosiduronic acid
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Accession:CHEBI:36489 term browser browse the term
Definition:A steroid glucosiduronic acid that consists of 17beta-estradiol having a beta-glucuronyl residue attached at position 3 via a glycosidic linkage.
Synonyms:exact_synonym: 17beta-hydroxyestra-1,3,5(10)-trien-3-yl beta-D-glucopyranosiduronic acid
 related_synonym: 17beta-Estradiol 3-(beta-D-glucuronide);   17beta-estradiol 3-glucuronide;   Estradiol-3-glucuronide;   Formula=C24H32O8;   InChI=1S/C24H32O8/c1-24-9-8-14-13-5-3-12(10-11(13)2-4-15(14)16(24)6-7-17(24)25)31-23-20(28)18(26)19(27)21(32-23)22(29)30/h3,5,10,14-21,23,25-28H,2,4,6-9H2,1H3,(H,29,30)/t14-,15-,16+,17+,18+,19+,20-,21+,23-,24+/m1/s1;   InChIKey=MUOHJTRCBBDUOW-QXYWQCSFSA-N;   SMILES=O([C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)C(O)=O)O)O)O)C2=CC3=C([C@@]4([C@]([C@]5([C@@]([C@@H](O)CC5)(CC4)C)[H])(CC3)[H])[H])C=C2
 alt_id: CHEBI:23964;   CHEBI:4865
 xref: Beilstein:1302617;   CAS:15270-30-1;   KEGG:C05503;   LIPID_MAPS_instance:LMST05010007
 xref_mesh: MESH:C025482
 xref: PMID:10365435;   PMID:10784423;   PMID:11812141;   PMID:11878459;   PMID:15516735;   PMID:15537867;   PMID:17612196;   PMID:20417221;   Reaxys:5658104
 cyclic_relationship: is_conjugate_acid_of CHEBI:136641


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17beta-estradiol 3-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity EXP estradiol-3-glucuronide results in decreased activity of ABCB11 protein CTD PMID:10869290 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Kl Klotho multiple interactions
increases hydrolysis		 ISO estradiol-3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]
KL protein results in increased hydrolysis of estradiol-3-glucuronide		 CTD PMID:14701853 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    role 19790
      application 19622
        pharmaceutical 19499
          drug 19499
            protective agent 18115
              geroprotector 17293
                17beta-estradiol 10636
                  17beta-estradiol 3-glucosiduronic acid 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      carbon group element atom 19703
                        carbon atom 19698
                          organic molecular entity 19698
                            heteroorganic entity 19453
                              organochalcogen compound 19240
                                organooxygen compound 19152
                                  carbohydrates and carbohydrate derivatives 14950
                                    carbohydrate 14950
                                      carbohydrate derivative 14223
                                        glycosyl compound 12952
                                          glycoside 11762
                                            glycosiduronic acid 176
                                              glucosiduronic acid 176
                                                beta-D-glucosiduronic acid 48
                                                  17beta-estradiol 3-glucosiduronic acid 2
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