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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:lupane
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Accession:CHEBI:36485 term browser browse the term
Definition:A triterpene that has formula C30H52.
Synonyms:related_synonym: Formula=C30H52;   InChI=1S/C30H52/c1-20(2)21-12-16-27(5)18-19-29(7)22(25(21)27)10-11-24-28(6)15-9-14-26(3,4)23(28)13-17-30(24,29)8/h20-25H,9-19H2,1-8H3/t21-,22+,23-,24+,25+,27+,28-,29+,30+/m0/s1;   InChIKey=NKMDIWKRKQFYPH-VIUFNMEASA-N;   SMILES=[H][C@]12CC[C@]3([H])[C@@]4(C)CCCC(C)(C)[C@]4([H])CC[C@@]3(C)[C@]1(C)CC[C@@]1(C)CC[C@@H](C(C)C)[C@]21[H]
 xref: Beilstein:2562721;   CAS:464-99-3
 xref_mesh: MESH:C480546



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lupane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd80 Cd80 molecule increases expression ISO lupane results in increased expression of CD80 protein CTD PMID:16388738 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
JBrowse link
G Cd83 CD83 molecule increases expression ISO lupane results in increased expression of CD83 protein CTD PMID:16388738 NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083
JBrowse link
G Cd86 CD86 molecule increases expression ISO lupane results in increased expression of CD86 protein CTD PMID:16388738 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Ifng interferon gamma increases secretion ISO lupane results in increased secretion of IFNG protein CTD PMID:16388738 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il12a interleukin 12A multiple interactions ISO lupane results in increased secretion of [IL12A protein binds to IL12B protein] CTD PMID:16388738 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B multiple interactions ISO lupane results in increased secretion of [IL12A protein binds to IL12B protein] CTD PMID:16388738 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
betulin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO betulin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; betulin inhibits the reaction [ABCB1 protein results in increased export of Rhodamine 123] CTD PMID:33321149 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP betulin inhibits the reaction [Ethanol results in increased expression of ACTA2 protein] CTD PMID:21172400 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO betulin results in increased phosphorylation of AKT1 protein CTD PMID:32190974 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO betulin results in increased expression of BAX protein CTD PMID:33181113 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [betulin co-treated with Oxygen deficiency] results in decreased expression of BCL2 protein CTD PMID:33181113 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression
ISO betulin analog promotes the reaction [Oxygen deficiency results in decreased expression of BIRC5 protein]
betulin analog results in decreased expression of BIRC5 protein
CTD PMID:26540049 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase multiple interactions ISO betulin affects the reaction [BRAF protein affects the reaction [Vemurafenib results in decreased cleavage of SREBF1 protein]]; betulin affects the reaction [BRAF protein affects the susceptibility to [dabrafenib co-treated with trametinib]]; betulin affects the reaction [BRAF protein affects the susceptibility to Vemurafenib] CTD PMID:29950559 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
JBrowse link
G Ca9 carbonic anhydrase 9 multiple interactions ISO betulin analog inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein] CTD PMID:26540049 NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
ISO betulin results in increased cleavage of CASP3 protein
Chloroquine inhibits the reaction [betulin results in increased cleavage of CASP3 protein]
CTD PMID:32190974 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases cleavage ISO betulin results in increased cleavage of CASP8 protein CTD PMID:32190974 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases cleavage ISO betulin results in increased cleavage of CASP9 protein CTD PMID:32190974 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO [betulin co-treated with Oxygen deficiency] results in decreased expression of CTNNB1 protein CTD PMID:33181113 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases phosphorylation
ISO [Gefitinib co-treated with betulin] results in decreased expression of and results in decreased phosphorylation of EGFR protein
betulin results in decreased phosphorylation of EGFR protein
CTD PMID:27447558 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation ISO betulin results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:32190974 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Fasn fatty acid synthase decreases expression ISO betulin results in decreased expression of FASN mRNA; betulin results in decreased expression of FASN protein CTD PMID:27378817 PMID:27447558 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO [betulin co-treated with Oxygen deficiency] affects the phosphorylation of GSK3B protein CTD PMID:33181113 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression
multiple interactions
ISO betulin analog results in decreased expression of HIF1A protein; betulin results in decreased expression of HIF1A protein
betulin analog inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]
CTD PMID:26540049 PMID:33181113 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression ISO betulin results in decreased expression of HMGCR mRNA; betulin results in decreased expression of HMGCR protein CTD PMID:27378817 PMID:27447558 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 decreases expression ISO betulin results in decreased expression of HMGCS1 mRNA CTD PMID:27378817 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Ifng interferon gamma increases secretion ISO betulin results in increased secretion of IFNG protein CTD PMID:25756279 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il12a interleukin 12A multiple interactions
increases expression
ISO betulin results in increased secretion of [IL12A protein binds to IL12B protein]
betulin results in increased expression of IL12A mRNA
CTD PMID:25756279 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B multiple interactions ISO betulin results in increased secretion of [IL12A protein binds to IL12B protein] CTD PMID:25756279 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il2 interleukin 2 increases secretion ISO betulin results in increased secretion of IL2 protein CTD PMID:25756279 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO [betulin co-treated with Oxygen deficiency] results in increased phosphorylation of MAPK1 protein
betulin results in increased phosphorylation of MAPK1 protein
CTD PMID:33181113 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO betulin results in increased phosphorylation of MAPK3 protein
[betulin co-treated with Oxygen deficiency] results in increased phosphorylation of MAPK3 protein
CTD PMID:33181113 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Marveld1 MARVEL domain containing 1 decreases expression ISO betulin results in decreased expression of MARVELD1 mRNA CTD PMID:27447558 NCBI chr 1:240,954,452...240,958,384
Ensembl chr 1:240,954,452...240,958,384
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO [Gefitinib co-treated with betulin] results in decreased expression of MKI67 protein CTD PMID:27447558 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP betulin inhibits the reaction [Ethanol results in increased expression of MMP2 protein] CTD PMID:21172400 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO betulin results in decreased phosphorylation of MTOR protein CTD PMID:32190974 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [betulin co-treated with Oxygen deficiency] results in decreased expression of MYC protein CTD PMID:33181113 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO [betulin co-treated with Oxygen] results in increased cleavage of PARP1 protein; betulin analog promotes the reaction [Oxygen deficiency results in increased expression of PARP1 protein modified form]; Chloroquine inhibits the reaction [betulin results in increased cleavage of PARP1 protein] CTD PMID:26540049 PMID:32190974 PMID:33181113 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP betulin inhibits the reaction [Ethanol results in increased phosphorylation of RELA protein] CTD PMID:21172400 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression ISO betulin results in decreased expression of SCD mRNA; betulin results in decreased expression of SCD protein CTD PMID:27378817 PMID:27447558 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Smad3 SMAD family member 3 multiple interactions EXP betulin inhibits the reaction [Ethanol results in increased phosphorylation of SMAD3 protein] CTD PMID:21172400 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases cleavage
multiple interactions
decreases expression
ISO betulin results in decreased cleavage of SREBF1 protein
[Gefitinib co-treated with betulin] results in decreased expression of SREBF1 protein; betulin affects the reaction [BRAF protein affects the reaction [Vemurafenib results in decreased cleavage of SREBF1 protein]]
betulin results in decreased expression of SREBF1 protein
CTD PMID:27447558 PMID:29950559 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases sulfation ISO SULT2A1 protein results in increased sulfation of betulin CTD PMID:30776358 NCBI chr 1:75,451,178...75,508,142 JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP betulin inhibits the reaction [Ethanol results in increased expression of TGFB1 protein] CTD PMID:21172400 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP betulin inhibits the reaction [Ethanol results in increased expression of TIMP1 protein] CTD PMID:21172400 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions EXP betulin inhibits the reaction [Ethanol results in increased expression of TIMP2 protein] CTD PMID:21172400 NCBI chr10:103,541,199...103,590,611 JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of betulin CTD PMID:30776358 NCBI chr 9:88,791,216...88,808,465 JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of betulin CTD PMID:30776358 NCBI chr 9:88,762,250...88,808,465 JBrowse link
betulinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP betulinic acid inhibits the reaction [Ethanol results in increased expression of ACTA2 protein]; betulinic acid inhibits the reaction [Thioacetamide results in increased expression of ACTA2] CTD PMID:21172400 PMID:22285267 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [betulinic acid results in increased phosphorylation of AKT1 protein] CTD PMID:16077934 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression
multiple interactions
ISO betulinic acid results in increased expression of BAK1 protein
[betulinic acid co-treated with Oxygen deficiency] results in increased expression of BAK1 protein
CTD PMID:33181113 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine co-treated with betulinic acid analog] results in increased activity of BAX protein; CA 074 methyl ester inhibits the reaction [[2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine co-treated with betulinic acid analog] results in increased activity of BAX protein] CTD PMID:23000516 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO betulinic acid results in decreased expression of BCL2 protein
[betulinic acid co-treated with Oxygen deficiency] results in decreased expression of BCL2 protein
CTD PMID:30136359 PMID:33181113 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression
decreases expression
decreases response to substance
multiple interactions
ISO betulinic acid results in increased expression of BIRC5
betulinic acid results in decreased expression of BIRC5 protein
BIRC5 protein results in decreased susceptibility to betulinic acid
4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [betulinic acid results in increased expression of BIRC5]; betulinic acid promotes the reaction [Oxygen deficiency results in decreased expression of BIRC5 protein]; Erlotinib Hydrochloride inhibits the reaction [betulinic acid results in decreased expression of BIRC5 protein]
CTD PMID:16077934 PMID:26540049 PMID:30136359 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Ca9 carbonic anhydrase 9 multiple interactions
decreases activity
ISO betulinic acid inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]
betulinic acid analog results in decreased activity of CA9 protein
CTD PMID:26540049 PMID:29454615 NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
increases activity
ISO betulinic acid analog results in increased cleavage of CASP3 protein; betulinic acid results in increased cleavage of CASP3 protein
betulinic acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; betulinic acid inhibits the reaction [Bortezomib results in increased cleavage of CASP3 protein]
betulinic acid analog results in increased activity of CASP3 protein; betulinic acid results in increased activity of CASP3 protein
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [betulinic acid analog results in increased cleavage of CASP3 protein]; betulinic acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; betulinic acid inhibits the reaction [Bortezomib results in increased cleavage of CASP3 protein]; CA 074 methyl ester inhibits the reaction [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [betulinic acid analog results in increased cleavage of CASP3 protein]]; VDAC1 protein inhibits the reaction [betulinic acid results in increased expression of CASP3 protein modified form]
CTD PMID:22260869 PMID:23000516 PMID:26772157 PMID:28578903 PMID:29454615 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions
ISO betulinic acid results in increased activity of CASP7 protein
VDAC1 protein inhibits the reaction [betulinic acid results in increased expression of CASP7 protein modified form]
CTD PMID:22260869 PMID:30136359 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 increases activity ISO betulinic acid results in increased activity of CASP8 protein CTD PMID:26772157 PMID:29454615 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity ISO betulinic acid analog results in increased activity of CASP9 protein; betulinic acid results in increased activity of CASP9 protein CTD PMID:26772157 PMID:29454615 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO betulinic acid results in decreased expression of CCNB1 protein CTD PMID:33181113 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
ISO betulinic acid analog results in decreased expression of CCND1 protein; betulinic acid results in decreased expression of CCND1 protein
[betulinic acid co-treated with Oxygen deficiency] results in decreased expression of CCND1 protein
CTD PMID:28254521 PMID:33181113 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions ISO betulinic acid promotes the reaction [Erlotinib Hydrochloride results in decreased expression of CDK6 protein]; betulinic acid promotes the reaction [Gefitinib results in decreased expression of CDK6 protein] CTD PMID:30136359 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO betulinic acid analog results in increased expression of CDKN1A protein CTD PMID:28254521 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions
decreases expression
ISO betulinic acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form]; betulinic acid inhibits the reaction [Bortezomib results in increased expression of CEBPB protein alternative form]
betulinic acid results in decreased expression of CEBPB protein modified form
CTD PMID:30482226 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression
ISO [betulinic acid co-treated with Erlotinib Hydrochloride] results in decreased expression of CTNNB1 protein; [betulinic acid co-treated with Oxygen deficiency] results in decreased expression of CTNNB1 protein
betulinic acid results in decreased expression of CTNNB1 protein
CTD PMID:30136359 PMID:33181113 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ctsk cathepsin K multiple interactions ISO betulinic acid inhibits the reaction [TNFSF11 protein results in increased secretion of CTSK protein] CTD PMID:24463094 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO betulinic acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; betulinic acid inhibits the reaction [Bortezomib results in increased expression of DDIT3 protein] CTD PMID:30482226 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases phosphorylation
ISO 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [betulinic acid results in increased phosphorylation of EGFR protein]; betulinic acid promotes the reaction [Gefitinib results in decreased expression of EGFR protein modified form] CTD PMID:16077934 PMID:30136359 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
multiple interactions
ISO betulinic acid results in increased phosphorylation of GSK3B protein
[betulinic acid co-treated with Oxygen deficiency] results in increased phosphorylation of GSK3B protein
CTD PMID:33181113 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression
multiple interactions
ISO betulinic acid results in decreased expression of HIF1A protein
[betulinic acid co-treated with Oxygen deficiency] affects the expression of HIF1A protein
CTD PMID:26540049 PMID:33181113 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hk2 hexokinase 2 multiple interactions ISO [VDAC1 protein results in decreased susceptibility to betulinic acid] which results in increased expression of HK2 protein CTD PMID:30136359 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression
ISO Erlotinib Hydrochloride promotes the reaction [betulinic acid results in increased expression of MAP1LC3B protein modified form] CTD PMID:30136359 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [betulinic acid results in increased phosphorylation of MAPK1 protein]; [betulinic acid co-treated with Oxygen deficiency] results in increased phosphorylation of MAPK1 protein CTD PMID:16077934 PMID:33181113 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [betulinic acid results in increased phosphorylation of MAPK3 protein]; [betulinic acid co-treated with Oxygen deficiency] results in increased phosphorylation of MAPK3 protein CTD PMID:16077934 PMID:33181113 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mir24-2 microRNA 24-2 affects response to substance
multiple interactions
ISO MIR24-2 mRNA affects the susceptibility to betulinic acid
MIR24-2 mRNA affects the susceptibility to [betulinic acid co-treated with gemcitabine]
CTD PMID:25841339 NCBI chr19:23,954,683...23,954,790
Ensembl chr19:23,954,683...23,954,790
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP
ISO
betulinic acid inhibits the reaction [Ethanol results in increased expression of MMP2 protein]
betulinic acid affects the reaction [TGFB1 protein affects the expression of and affects the secretion of MMP2 protein]
betulinic acid inhibits the reaction [TNFSF11 protein results in increased secretion of MMP2 protein]
CTD PMID:21172400 PMID:24463094 PMID:28578903 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO betulinic acid inhibits the reaction [TNFSF11 protein results in increased secretion of MMP9 protein] CTD PMID:24463094 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [betulinic acid co-treated with Oxygen deficiency] results in decreased expression of MYC protein CTD PMID:33181113 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP betulinic acid inhibits the reaction [Ethanol results in increased phosphorylation of NFKBIA protein] CTD PMID:21172400 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions ISO betulinic acid inhibits the reaction [Bortezomib results in increased expression of NOS1 protein] CTD PMID:30482226 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression
multiple interactions
increases cleavage
ISO betulinic acid results in increased expression of PARP1 protein modified form
[betulinic acid co-treated with Oxygen] results in increased cleavage of PARP1 protein; betulinic acid promotes the reaction [Gefitinib results in increased cleavage of PARP1 protein]
betulinic acid results in increased cleavage of PARP1 protein
CTD PMID:26540049 PMID:30136359 PMID:33181113 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO betulinic acid analog results in decreased expression of PCNA protein CTD PMID:28254521 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pla2g2a phospholipase A2 group IIA affects binding ISO betulinic acid binds to PLA2G2A protein CTD PMID:29391000 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014
JBrowse link
G Pthlh parathyroid hormone-like hormone multiple interactions
decreases response to substance
decreases expression
decreases secretion
ISO betulinic acid inhibits the reaction [PTHLH protein results in increased expression of TNFSF11 protein]
betulinic acid results in decreased susceptibility to PTHLH protein
betulinic acid results in decreased expression of PTHLH mRNA
betulinic acid results in decreased secretion of PTHLH protein
CTD PMID:24463094 NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
decreases expression
ISO betulinic acid promotes the reaction [Erlotinib Hydrochloride results in decreased expression of RB1 protein modified form]; betulinic acid promotes the reaction [Gefitinib results in decreased expression of RB1 protein modified form]; Erlotinib Hydrochloride promotes the reaction [betulinic acid results in decreased expression of RB1 protein modified form]; Gefitinib promotes the reaction [betulinic acid results in decreased expression of RB1 protein modified form] CTD PMID:30136359 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP betulinic acid inhibits the reaction [Ethanol results in increased phosphorylation of RELA protein] CTD PMID:21172400 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Smad3 SMAD family member 3 multiple interactions EXP betulinic acid inhibits the reaction [Ethanol results in increased phosphorylation of SMAD3 protein] CTD PMID:21172400 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [betulinic acid co-treated with Erlotinib Hydrochloride] results in decreased expression of STAT3 protein modified form CTD PMID:30136359 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP
ISO
betulinic acid inhibits the reaction [Ethanol results in increased expression of TGFB1 protein]
betulinic acid affects the reaction [TGFB1 protein affects the expression of and affects the secretion of MMP2 protein]
CTD PMID:21172400 PMID:28578903 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP betulinic acid inhibits the reaction [Ethanol results in increased expression of TIMP1 protein] CTD PMID:21172400 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions EXP betulinic acid inhibits the reaction [Ethanol results in increased expression of TIMP2 protein] CTD PMID:21172400 NCBI chr10:103,541,199...103,590,611 JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions
decreases response to substance
ISO betulinic acid inhibits the reaction [PTHLH protein results in increased expression of TNFSF11 protein]
betulinic acid results in decreased susceptibility to TNFSF11 protein
betulinic acid inhibits the reaction [TNFSF11 protein results in increased secretion of CTSK protein]; betulinic acid inhibits the reaction [TNFSF11 protein results in increased secretion of MMP2 protein]; betulinic acid inhibits the reaction [TNFSF11 protein results in increased secretion of MMP9 protein]
CTD PMID:24463094 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Top1 DNA topoisomerase I decreases activity ISO betulinic acid results in decreased activity of TOP1 protein CTD PMID:10860928 NCBI chr 3:149,293,658...149,375,405
Ensembl chr 3:149,293,403...149,376,623
JBrowse link
G Top2a DNA topoisomerase II alpha decreases activity ISO betulinic acid results in decreased activity of TOP2A protein CTD PMID:10860928 NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874
JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
ISO betulinic acid results in increased expression of TP53 protein
[betulinic acid co-treated with Oxygen deficiency] results in increased expression of TP53 protein
CTD PMID:33181113 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Trib3 tribbles pseudokinase 3 multiple interactions ISO betulinic acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; betulinic acid inhibits the reaction [Bortezomib results in increased expression of TRIB3 protein] CTD PMID:30482226 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
JBrowse link
G Tyms thymidylate synthetase decreases expression
multiple interactions
ISO betulinic acid results in decreased expression of TYMS protein
betulinic acid promotes the reaction [Erlotinib Hydrochloride results in decreased expression of TYMS protein]; betulinic acid promotes the reaction [Gefitinib results in decreased expression of TYMS protein]; Erlotinib Hydrochloride promotes the reaction [betulinic acid results in decreased expression of TYMS protein]; Gefitinib promotes the reaction [betulinic acid results in decreased expression of TYMS protein]
CTD PMID:30136359 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
JBrowse link
G Vdac1 voltage-dependent anion channel 1 decreases response to substance
multiple interactions
increases expression
ISO VDAC1 protein results in decreased susceptibility to betulinic acid
[VDAC1 protein results in decreased susceptibility to betulinic acid] which results in increased expression of HK2 protein; VDAC1 protein inhibits the reaction [betulinic acid results in increased expression of CASP3 protein modified form]; VDAC1 protein inhibits the reaction [betulinic acid results in increased expression of CASP7 protein modified form]
betulinic acid results in increased expression of VDAC1 protein
CTD PMID:30136359 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
JBrowse link
lupeol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 decreases expression ISO lupeol results in decreased expression of ABCG2 protein CTD PMID:20979057 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO lupeol inhibits the reaction [mancozeb results in increased expression of BAX mRNA]
lupeol results in increased expression of BAX mRNA; lupeol results in increased expression of BAX protein
CTD PMID:27235710 PMID:30506710 PMID:31112703 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO lupeol inhibits the reaction [mancozeb results in decreased expression of BCL2 mRNA]
lupeol results in decreased expression of BCL2 mRNA; lupeol results in decreased expression of BCL2 protein
CTD PMID:27235710 PMID:30506710 PMID:31112703 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 increases expression ISO lupeol results in increased expression of CASP3 mRNA; lupeol results in increased expression of CASP3 protein CTD PMID:30506710 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases expression ISO lupeol results in increased expression of CASP8 mRNA; lupeol results in increased expression of CASP8 protein CTD PMID:30506710 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases expression ISO lupeol results in increased expression of CASP9 mRNA; lupeol results in increased expression of CASP9 protein CTD PMID:30506710 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions EXP
ISO
lupeol inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased activity of CAT protein]; lupeol inhibits the reaction [Sodium Selenite results in decreased activity of CAT protein]
lupeol inhibits the reaction [mancozeb results in decreased activity of CAT protein]
CTD PMID:16933029 PMID:26697995 PMID:27235710 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO lupeol results in decreased expression of CCND1 mRNA CTD PMID:20732907 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdh1 cadherin 1 increases expression ISO lupeol results in increased expression of CDH1 mRNA; lupeol results in increased expression of CDH1 protein CTD PMID:31112703 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO lupeol inhibits the reaction [mancozeb results in increased expression of CDKN1A mRNA] CTD PMID:27235710 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cryz crystallin zeta multiple interactions ISO lupeol inhibits the reaction [Benzoyl Peroxide affects the activity of CRYZ protein] CTD PMID:15248479 NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758
JBrowse link
G Ctnnb1 catenin beta 1 decreases expression
multiple interactions
ISO lupeol results in decreased expression of CTNNB1 protein
lupeol results in decreased localization of and results in decreased activity of CTNNB1 protein
CTD PMID:20732907 PMID:20979057 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions ISO lupeol inhibits the reaction [mancozeb results in increased expression of GADD45A mRNA] CTD PMID:27235710 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta affects binding EXP lupeol binds to GSK3B protein CTD PMID:18222664 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP lupeol inhibits the reaction [Sodium Selenite results in decreased activity of GSR protein] CTD PMID:26697995 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Il10 interleukin 10 decreases expression ISO lupeol results in decreased expression of IL10 mRNA CTD PMID:31112703 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta decreases expression ISO lupeol results in decreased expression of IL1B mRNA CTD PMID:31112703 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 decreases expression ISO lupeol results in decreased expression of IL6 mRNA CTD PMID:31112703 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions ISO lupeol inhibits the reaction [mancozeb results in increased expression of MDM2 mRNA] CTD PMID:27235710 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO lupeol results in decreased expression of MKI67 mRNA CTD PMID:20732907 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [lupeol binds to stearic acid] inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of MPO protein] CTD PMID:32006539 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO lupeol results in decreased expression of MYC mRNA CTD PMID:20732907 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nanog Nanog homeobox decreases expression ISO lupeol results in decreased expression of NANOG protein CTD PMID:20979057 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116
JBrowse link
G Nes nestin decreases expression ISO lupeol results in decreased expression of NES protein CTD PMID:20979057 NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase multiple interactions ISO lupeol inhibits the reaction [mancozeb results in decreased expression of OGG1 mRNA] CTD PMID:27235710 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO lupeol results in decreased expression of PCNA mRNA CTD PMID:20732907 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression ISO lupeol results in decreased expression of POU5F1 protein CTD PMID:20979057 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
JBrowse link
G Prom1 prominin 1 decreases expression ISO lupeol results in decreased expression of PROM1 protein CTD PMID:20979057 NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527
JBrowse link
G Pten phosphatase and tensin homolog increases expression
increases response to substance
ISO lupeol results in increased expression of PTEN protein
PTEN protein results in increased susceptibility to lupeol
CTD PMID:20979057 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptges prostaglandin E synthase multiple interactions ISO lupeol inhibits the reaction [mancozeb results in increased expression of PTGES mRNA] CTD PMID:27235710 NCBI chr 3:14,177,892...14,189,236 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO lupeol inhibits the reaction [mancozeb affects the localization of RELA protein] CTD PMID:27235710 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sox2 SRY-box transcription factor 2 decreases expression ISO lupeol results in decreased expression of SOX2 protein CTD PMID:20979057 NCBI chr 2:117,536,929...117,539,338
Ensembl chr 2:117,536,929...117,539,338
JBrowse link
G Tnf tumor necrosis factor decreases expression ISO lupeol results in decreased expression of TNF mRNA CTD PMID:31112703 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO lupeol inhibits the reaction [mancozeb results in increased expression of TP53 mRNA] CTD PMID:27235710 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO lupeol inhibits the reaction [Benzoyl Peroxide affects the activity of XDH protein] CTD PMID:15248479 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link
G Xrcc1 X-ray repair cross complementing 1 multiple interactions ISO lupeol inhibits the reaction [mancozeb results in decreased expression of XRCC1 mRNA] CTD PMID:27235710 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      atom 19799
        nonmetal atom 19686
          carbon atom 19609
            organic molecular entity 19609
              organic fundamental parent 18348
                natural product fundamental parent 13652
                  terpenoid fundamental parent 3517
                    lupane 93
                      (20R)-28-hydroxylupen-30-al-3-one 0
                      2-O-E-p-coumaroyl alphitolic acid 0
                      20(29)-lupene-1beta,3alpha-diol 0
                      20(29)-lupene-1beta,3beta-diol 0
                      23-Hydroxybetulinic acid 0
                      2alpha,3beta,23-trihydroxylup-20(29)-en-28-oic acid 0
                      2alpha,3beta-dihydroxy-20(29)-lupen-28-oic acid 0
                      2alpha,3beta-dihydroxylup-20(29)-ene 0
                      3-(Z)-caffeoyllupeol 0
                      3beta-O-cis-caffeoylbetulinic acid 0
                      3beta-O-trans-caffeoylbetulinic acid 0
                      betulin + 41
                      betulinic acid + 50
                      betulone 0
                      dihydrobetulinic acid 0
                      glochidone 0
                      glochidonol 0
                      lupenone 0
                      lupeol + 36
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    main group molecular entity 19698
                      s-block molecular entity 19479
                        hydrogen molecular entity 19471
                          hydrides 18834
                            organic hydride 18348
                              organic fundamental parent 18348
                                hydrocarbon 18059
                                  terpene 12725
                                    triterpene 745
                                      lupane 93
                                        (20R)-28-hydroxylupen-30-al-3-one 0
                                        2-O-E-p-coumaroyl alphitolic acid 0
                                        20(29)-lupene-1beta,3alpha-diol 0
                                        20(29)-lupene-1beta,3beta-diol 0
                                        23-Hydroxybetulinic acid 0
                                        2alpha,3beta,23-trihydroxylup-20(29)-en-28-oic acid 0
                                        2alpha,3beta-dihydroxy-20(29)-lupen-28-oic acid 0
                                        2alpha,3beta-dihydroxylup-20(29)-ene 0
                                        3-(Z)-caffeoyllupeol 0
                                        3beta-O-cis-caffeoylbetulinic acid 0
                                        3beta-O-trans-caffeoylbetulinic acid 0
                                        betulin + 41
                                        betulinic acid + 50
                                        betulone 0
                                        dihydrobetulinic acid 0
                                        glochidone 0
                                        glochidonol 0
                                        lupenone 0
                                        lupeol + 36
paths to the root