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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:quinazoline alkaloid
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Accession:CHEBI:36470 term browser browse the term
Definition:Any alkaloid based on a quinazoline skeleton and its substituted derivatives.
Synonyms:related_synonym: quinazoline alkaloids



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Anhydrotetrodotoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn8a sodium channel, voltage-gated, type VIII, alpha decreases activity EXP anhydrotetrodotoxin results in decreased activity of SCN8A protein CTD PMID:17522141 NCBI chr15:100,766,600...100,943,819
Ensembl chr15:100,767,739...100,943,819
JBrowse link
tetrodotoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl-hydrocarbon receptor multiple interactions ISO Tetrodotoxin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]] CTD PMID:17973980 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037
JBrowse link
G App amyloid beta precursor protein multiple interactions EXP
ISO
Tetrodotoxin inhibits the reaction [DDT results in increased expression of APP mRNA]; Tetrodotoxin inhibits the reaction [DDT results in increased expression of APP protein] CTD PMID:35946953 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
JBrowse link
G Arc activity regulated cytoskeletal-associated protein multiple interactions EXP Tetrodotoxin inhibits the reaction [ciguatoxin 3C results in increased expression of ARC mRNA] CTD PMID:25945544 NCBI chr15:74,540,930...74,544,419
Ensembl chr15:74,540,932...74,544,419
JBrowse link
G Bdnf brain derived neurotrophic factor multiple interactions EXP
ISO
Tetrodotoxin inhibits the reaction [Azacitidine results in decreased methylation of BDNF promoter]; Tetrodotoxin inhibits the reaction [Azacitidine results in increased expression of BDNF mRNA]
Tetrodotoxin inhibits the reaction [decamethrin results in increased expression of BDNF mRNA]; Tetrodotoxin inhibits the reaction [Veratridine results in increased expression of BDNF mRNA]
3,5-dichloro-N-(1-(2,2-dimethyltetrahydropyran-4-ylmethyl)-4-fluoropiperidin-4-ylmethyl)benzamide promotes the reaction [Tetrodotoxin inhibits the reaction [Oxygen deficiency promotes the reaction [BDNF protein results in increased transport of Calcium]]]; Tetrodotoxin inhibits the reaction [Oxygen deficiency promotes the reaction [BDNF protein results in increased transport of Calcium]]
CTD PMID:16166269 PMID:18184782 PMID:26095976 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352
JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV multiple interactions ISO Tetrodotoxin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of CAMK4 protein] CTD PMID:17973980 NCBI chr18:33,067,995...33,328,820
Ensembl chr18:33,067,984...33,324,281
JBrowse link
G Chrna7 cholinergic receptor, nicotinic, alpha polypeptide 7 multiple interactions ISO Tetrodotoxin inhibits the reaction [[3-(4-hydroxy-2-methoxybenzylidene)anabaseine co-treated with 5-hydroxyindole] results in increased activity of CHRNA7 protein] CTD PMID:18321476 NCBI chr 7:62,748,440...62,862,274
Ensembl chr 7:62,748,440...62,862,317
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Tetrodotoxin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CREB1 protein binds to CYP1A1 promoter]] CTD PMID:17973980 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707
JBrowse link
G Crh corticotropin releasing hormone decreases activity ISO Tetrodotoxin results in decreased activity of CRH protein CTD PMID:12906840 NCBI chr 3:19,747,565...19,749,560
Ensembl chr 3:19,747,565...19,749,560
JBrowse link
G Cybb cytochrome b-245, beta polypeptide multiple interactions EXP [Tetrodotoxin co-treated with cariporide] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CYBB mRNA]; [Tetrodotoxin co-treated with cariporide] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CYBB protein]; Tetrodotoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CYBB mRNA]; Tetrodotoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CYBB protein] CTD PMID:24070585 NCBI chr  X:9,301,493...9,354,005
Ensembl chr  X:9,301,491...9,354,010
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Tetrodotoxin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]]; Tetrodotoxin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CREB1 protein binds to CYP1A1 promoter]] CTD PMID:17973980 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 multiple interactions ISO [Bupivacaine co-treated with Tetrodotoxin co-treated with Dexamethasone] results in decreased expression of CYP3A9 mRNA CTD PMID:22341215 NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881
JBrowse link
G Egr1 early growth response 1 multiple interactions EXP Tetrodotoxin inhibits the reaction [ciguatoxin 3C results in increased expression of EGR1 mRNA] CTD PMID:25945544 NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037
JBrowse link
G Entpd4 ectonucleoside triphosphate diphosphohydrolase 4 multiple interactions ISO [Bupivacaine co-treated with Tetrodotoxin co-treated with Dexamethasone] results in decreased expression of ENTPD4 mRNA CTD PMID:22341215 NCBI chr14:69,574,600...69,604,191
Ensembl chr14:69,574,623...69,604,719
JBrowse link
G Erich5 glutamate rich 5 increases expression EXP Tetrodotoxin results in increased expression of ERICH5 mRNA CTD PMID:26436198 NCBI chr15:34,453,458...34,474,038
Ensembl chr15:34,453,451...34,474,038
JBrowse link
G Fos FBJ osteosarcoma oncogene decreases expression ISO Tetrodotoxin results in decreased expression of FOS mRNA; Tetrodotoxin results in decreased expression of FOS protein CTD PMID:7534335 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 decreases secretion EXP Tetrodotoxin results in decreased secretion of GNRH1 protein CTD PMID:28731686 NCBI chr14:67,982,717...67,986,889
Ensembl chr14:67,982,630...67,986,888
JBrowse link
G Gria1 glutamate receptor, ionotropic, AMPA1 (alpha 1) increases localization
multiple interactions
ISO Tetrodotoxin results in increased localization of GRIA1 protein
[Lead co-treated with Tetrodotoxin] results in increased expression of [GRIA1 protein binds to GRIA2 protein]
CTD PMID:19674091 PMID:29939358 NCBI chr11:56,902,342...57,221,070
Ensembl chr11:56,902,213...57,221,070
JBrowse link
G Gria2 glutamate receptor, ionotropic, AMPA2 (alpha 2) increases localization
multiple interactions
increases expression
ISO
EXP
Tetrodotoxin results in increased localization of GRIA2 protein
Tetrodotoxin inhibits the reaction [ciguatoxin 3C results in decreased expression of GRIA2 protein]
Tetrodotoxin results in increased expression of GRIA2 protein
[Lead co-treated with Tetrodotoxin] results in increased expression of [GRIA1 protein binds to GRIA2 protein]
CTD PMID:19674091 PMID:25945544 PMID:29939358 NCBI chr 3:80,588,757...80,711,534
Ensembl chr 3:80,588,757...80,710,142
JBrowse link
G Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) multiple interactions EXP Tetrodotoxin inhibits the reaction [ciguatoxin 3C results in decreased expression of GRIN2A protein] CTD PMID:25945544 NCBI chr16:9,385,765...9,813,744
Ensembl chr16:9,385,762...9,813,424
JBrowse link
G Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) multiple interactions EXP Tetrodotoxin inhibits the reaction [ciguatoxin 3C results in decreased expression of GRIN2B protein] CTD PMID:25945544 NCBI chr 6:135,690,219...136,150,658
Ensembl chr 6:135,690,231...136,150,509
JBrowse link
G Jun jun proto-oncogene multiple interactions ISO Tetrodotoxin inhibits the reaction [4-OH-2',3,3',4',5'-pentachlorobiphenyl results in increased expression of JUN protein] CTD PMID:16300829 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
JBrowse link
G Kcnc1 potassium voltage gated channel, Shaw-related subfamily, member 1 decreases expression ISO Tetrodotoxin results in decreased expression of KCNC1 mRNA CTD PMID:18775767 NCBI chr 7:46,045,643...46,088,130
Ensembl chr 7:46,045,921...46,088,128
JBrowse link
G Kcnc2 potassium voltage gated channel, Shaw-related subfamily, member 2 decreases expression ISO Tetrodotoxin results in decreased expression of KCNC2 mRNA; Tetrodotoxin results in decreased expression of KCNC2 protein CTD PMID:18775767 NCBI chr10:112,105,803...112,302,209
Ensembl chr10:112,107,026...112,302,929
JBrowse link
G Kiss1 KiSS-1 metastasis-suppressor multiple interactions EXP Tetrodotoxin inhibits the reaction [[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium]; Tetrodotoxin promotes the reaction [2-aminoethyl diphenylborinate inhibits the reaction [[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium]] CTD PMID:18948403 NCBI chr 1:133,249,625...133,257,460
Ensembl chr 1:133,237,565...133,257,460
Ensembl chr 1:133,237,565...133,257,460
JBrowse link
G Kiss1r KISS1 receptor multiple interactions EXP Tetrodotoxin inhibits the reaction [[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium]; Tetrodotoxin promotes the reaction [2-aminoethyl diphenylborinate inhibits the reaction [[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium]] CTD PMID:18948403 NCBI chr10:79,752,786...79,759,922
Ensembl chr10:79,752,805...79,758,107
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO
EXP
Tetrodotoxin inhibits the reaction [Permethrin results in increased phosphorylation of MAPK1 protein]
Tetrodotoxin results in decreased phosphorylation of MAPK1 protein
Tetrodotoxin inhibits the reaction [Bmk NT1 toxin, Buthus martensii Karsch results in increased phosphorylation of MAPK1 protein]
CTD PMID:15086530 PMID:30205134 PMID:30940546 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 decreases phosphorylation
multiple interactions
ISO
EXP
Tetrodotoxin results in decreased phosphorylation of MAPK3 protein
Tetrodotoxin inhibits the reaction [Permethrin results in increased phosphorylation of MAPK3 protein]
Tetrodotoxin inhibits the reaction [Bmk NT1 toxin, Buthus martensii Karsch results in increased phosphorylation of MAPK3 protein]
CTD PMID:15086530 PMID:30205134 PMID:30940546 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Masp2 MBL associated serine protease 2 increases expression EXP Tetrodotoxin results in increased expression of MASP2 mRNA CTD PMID:26436198 NCBI chr 4:148,679,079...148,699,939
Ensembl chr 4:148,687,011...148,699,956
JBrowse link
G Npy neuropeptide Y multiple interactions ISO Tetrodotoxin inhibits the reaction [Veratridine results in increased expression of NPY mRNA] CTD PMID:2233698 NCBI chr 6:49,799,690...49,806,487
Ensembl chr 6:49,799,690...49,806,487
JBrowse link
G Prkcb protein kinase C, beta multiple interactions ISO [Bupivacaine co-treated with Tetrodotoxin co-treated with Dexamethasone] results in decreased expression of PRKCB mRNA CTD PMID:22341215 NCBI chr 7:121,888,327...122,233,625
Ensembl chr 7:121,887,974...122,233,625
JBrowse link
G Pvalb parvalbumin decreases expression ISO Tetrodotoxin results in decreased expression of PVALB mRNA CTD PMID:18775767 NCBI chr15:78,075,312...78,090,600
Ensembl chr15:78,075,314...78,090,600
JBrowse link
G Rhbdl2 rhomboid like 2 increases expression EXP Tetrodotoxin results in increased expression of RHBDL2 mRNA CTD PMID:26436198 NCBI chr 4:123,681,642...123,723,993
Ensembl chr 4:123,681,667...123,723,697
JBrowse link
G Scn1b sodium channel, voltage-gated, type I, beta multiple interactions ISO Tetrodotoxin results in decreased activity of [SCN2A protein binds to SCN1B protein]; Tetrodotoxin results in decreased activity of [SCN8A protein binds to SCN1B protein binds to SCN2B protein] CTD PMID:9236205 PMID:21983428 NCBI chr 7:30,815,949...30,826,436
Ensembl chr 7:30,815,949...30,826,428
JBrowse link
G Scn2a sodium channel, voltage-gated, type II, alpha multiple interactions
decreases activity
ISO Tetrodotoxin results in decreased activity of [SCN2A protein binds to SCN1B protein]
Tetrodotoxin inhibits the reaction [decamethrin results in decreased expression of SCN2A mRNA]
Tetrodotoxin results in decreased activity of SCN2A protein
CTD PMID:9236205 PMID:22972919 PMID:25358543 NCBI chr 2:65,451,108...65,597,791
Ensembl chr 2:65,451,115...65,597,791
JBrowse link
G Scn2b sodium channel, voltage-gated, type II, beta multiple interactions ISO Tetrodotoxin results in decreased activity of [SCN8A protein binds to SCN1B protein binds to SCN2B protein] CTD PMID:21983428 NCBI chr 9:45,029,174...45,041,368
Ensembl chr 9:45,029,080...45,041,368
JBrowse link
G Scn3a sodium channel, voltage-gated, type III, alpha multiple interactions ISO Tetrodotoxin inhibits the reaction [decamethrin results in decreased expression of SCN3A mRNA] CTD PMID:25358543 NCBI chr 2:65,287,462...65,397,935
Ensembl chr 2:65,288,607...65,397,971
JBrowse link
G Scn5a sodium channel, voltage-gated, type V, alpha decreases activity ISO Tetrodotoxin results in decreased activity of SCN5A protein CTD PMID:17978865 NCBI chr 9:119,312,470...119,408,096
Ensembl chr 9:119,312,474...119,408,082
JBrowse link
G Scn8a sodium channel, voltage-gated, type VIII, alpha multiple interactions
decreases activity
EXP
ISO
[Tetrodotoxin results in decreased activity of [SCN8A protein co-treated with SCN9A protein]] which affects the transport of Sodium; Tetrodotoxin affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of SCN8A protein]; Tetrodotoxin inhibits the reaction [SCN8A protein results in increased transport of Sodium]
Tetrodotoxin results in decreased activity of SCN8A protein
Tetrodotoxin results in decreased activity of [SCN8A protein binds to SCN1B protein binds to SCN2B protein]
CTD PMID:16020462 PMID:17522141 PMID:21983428 PMID:23382806 PMID:24070585 NCBI chr15:100,766,600...100,943,819
Ensembl chr15:100,767,739...100,943,819
JBrowse link
G Scn9a sodium channel, voltage-gated, type IX, alpha decreases activity
multiple interactions
ISO
EXP
Tetrodotoxin results in decreased activity of SCN9A protein
[Tetrodotoxin results in decreased activity of [SCN8A protein co-treated with SCN9A protein]] which affects the transport of Sodium; Tetrodotoxin inhibits the reaction [SCN9A protein results in increased transport of Sodium]
CTD PMID:16020462 PMID:17522141 PMID:23382806 NCBI chr 2:66,310,424...66,465,456
Ensembl chr 2:66,310,424...66,465,306
JBrowse link
G Sct secretin multiple interactions ISO Tetrodotoxin inhibits the reaction [Potassium Chloride results in increased secretion of SCT protein] CTD PMID:15963647 PMID:16888165 NCBI chr 7:140,858,243...140,859,082
Ensembl chr 7:140,858,243...140,859,046
JBrowse link
G Slc9a1 solute carrier family 9 (sodium/hydrogen exchanger), member 1 multiple interactions EXP [cariporide co-treated with Tetrodotoxin] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SLC9A1 protein]; Tetrodotoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SLC9A1 protein] CTD PMID:24070585 NCBI chr 4:133,097,022...133,151,013
Ensembl chr 4:133,097,017...133,151,013
JBrowse link
G Tcf25 transcription factor 25 (basic helix-loop-helix) increases expression EXP Tetrodotoxin results in increased expression of TCF25 mRNA CTD PMID:26436198 NCBI chr 8:124,097,511...124,130,913
Ensembl chr 8:124,100,492...124,130,574
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP cariporide promotes the reaction [Tetrodotoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]]; Tetrodotoxin inhibits the reaction [decamethrin results in increased secretion of TNF protein]; Tetrodotoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; Tetrodotoxin inhibits the reaction [Permethrin results in increased secretion of TNF protein]; Tetrodotoxin promotes the reaction [cariporide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]] CTD PMID:24070585 PMID:27655349 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      biological role 22162
        biochemical role 21431
          metabolite 21379
            alkaloid 7888
              quinazoline alkaloid 43
                (+/-)-tetrodotoxin 0
                (11S,13S)-3-Amino-5,12,13,14-tetrahydroxy-14-(hydroxymethyl)-8,10-dioxa-2-aza-4-azoniatetracyclo[7.3.1.17,11.01,6]tetradec-3-en-9-olate 0
                (11s,13s)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol 0
                Anhydrotetrodotoxin 1
                asperlicins + 0
                chrysogine 0
                penipanoid C 0
                tetrodotoxin + 43
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      carbon group element atom 21904
                        carbon atom 21859
                          organic molecular entity 21830
                            organic molecule 21647
                              organic cyclic compound 21252
                                organic heterocyclic compound 20352
                                  organic heteropolycyclic compound 19645
                                    organic heterobicyclic compound 18203
                                      quinazolines 543
                                        quinazoline alkaloid 43
                                          (+/-)-tetrodotoxin 0
                                          (11S,13S)-3-Amino-5,12,13,14-tetrahydroxy-14-(hydroxymethyl)-8,10-dioxa-2-aza-4-azoniatetracyclo[7.3.1.17,11.01,6]tetradec-3-en-9-olate 0
                                          (11s,13s)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol 0
                                          Anhydrotetrodotoxin 1
                                          asperlicins + 0
                                          chrysogine 0
                                          penipanoid C 0
                                          tetrodotoxin + 43
paths to the root