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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phenanthridine
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Accession:CHEBI:36421 term browser browse the term
Definition:An azaarene that is the 9-aza derivative of phenanthrene. The parent of the class of phenanthridines.
Synonyms:related_synonym: 3,4-benzoisoquinoline;   3,4-benzoquinoline;   6-phenanthridine;   9-azaphenanthrene;   Formula=C13H9N;   InChI=1S/C13H9N/c1-2-6-11-10(5-1)9-14-13-8-4-3-7-12(11)13/h1-9H;   InChIKey=RDOWQLZANAYVLL-UHFFFAOYSA-N;   SMILES=c1ccc2c(c1)cnc1ccccc21;   benzo[c]quinoline
 xref: CAS:229-87-8;   PMID:18522130;   PMID:24452525;   PMID:24547771;   Reaxys:120204;   Wikipedia:Phenanthridine



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ethidium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Ethidium inhibits the reaction [Estradiol results in increased expression of BCL2 mRNA] CTD PMID:15897899 NCBI chr13:23,204,464...23,366,900 JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Ethidium inhibits the reaction [Estradiol results in increased expression of CCND1 mRNA] CTD PMID:15897899 NCBI chr 1:209,518,288...209,527,986 JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO Ethidium inhibits the reaction [Estradiol results in increased expression of CCNE1 mRNA] CTD PMID:15897899 NCBI chr 1:99,918,672...99,927,986 JBrowse link
G Ccne2 cyclin E2 multiple interactions ISO Ethidium inhibits the reaction [Estradiol results in increased expression of CCNE2 mRNA] CTD PMID:15897899 NCBI chr 5:29,082,169...29,094,879 JBrowse link
G Cd59b CD59b molecule increases mutagenesis ISO Ethidium results in increased mutagenesis of CD59 protein CTD PMID:17045307 NCBI chr 3:110,914,008...110,932,489 JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha multiple interactions ISO [Pyruvic Acid co-treated with Uridine co-treated with Ethidium] inhibits the reaction [Rotenone inhibits the reaction [arsenite results in increased expression of ERO1A protein]] CTD PMID:37659621 NCBI chr15:18,495,037...18,530,440 JBrowse link
G Gja1 gap junction protein, alpha 1 increases uptake EXP GJA1 protein results in increased uptake of Ethidium CTD PMID:26926986 NCBI chr20:36,302,490...36,315,010 JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Ethidium inhibits the reaction [sodium arsenate results in increased expression of IL1A protein]; Ethidium inhibits the reaction [tributyltin results in increased expression of IL1A protein] CTD PMID:8875956 PMID:10571731 NCBI chr 3:136,979,804...136,990,236 JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I decreases expression ISO Ethidium results in decreased expression of COX1 protein CTD PMID:18823003
G Mt-co2 mitochondrially encoded cytochrome c oxidase II decreases expression ISO Ethidium results in decreased expression of COX2 mRNA CTD PMID:22712077
G Mt-cyb mitochondrially encoded cytochrome b decreases expression ISO Ethidium results in decreased expression of CYTB mRNA CTD PMID:22712077 NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
JBrowse link
G Mt-nd1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 decreases expression ISO Ethidium results in decreased expression of ND1 mRNA CTD PMID:22712077 NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
JBrowse link
G Mt-nd4 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 decreases expression ISO Ethidium results in decreased expression of ND4 mRNA CTD PMID:22712077 NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
JBrowse link
G Nrf1 nuclear respiratory factor 1 increases expression ISO Ethidium results in increased expression of NRF1 mRNA CTD PMID:22712077 NCBI chr 4:58,664,932...58,772,328 JBrowse link
G P2rx7 purinergic receptor P2X 7 decreases transport
increases transport
ISO P2RX7 gene polymorphism results in decreased transport of Ethidium
P2RX7 protein results in increased transport of Ethidium
CTD PMID:16263709 NCBI chr12:39,550,531...39,594,984 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Ethidium inhibits the reaction [cyanoginosin LR results in increased phosphorylation of RELA protein] CTD PMID:35032610 NCBI chr 1:212,354,336...212,364,815 JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions
affects uptake
increases uptake
ISO 1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]; Cimetidine inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]; Quinine inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]; Tetraethylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]
SLC22A1 protein affects the uptake of Ethidium
CTD PMID:19357179 NCBI chr 1:50,624,339...50,651,437 JBrowse link
G Slc22a2 solute carrier family 22 member 2 affects uptake
increases uptake
multiple interactions
ISO SLC22A2 protein affects the uptake of Ethidium
SLC22A2 protein results in increased uptake of Ethidium
1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]; Cimetidine inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]; Ethidium inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Quinine inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]; Tetraethylammonium inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]
CTD PMID:19357179 NCBI chr 1:50,668,817...50,711,019 JBrowse link
G Slc22a3 solute carrier family 22 member 3 increases uptake
multiple interactions
ISO SLC22A3 protein results in increased uptake of Ethidium
1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]; Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]; Quinine inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]; Tetraethylammonium inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]
CTD PMID:19357179 NCBI chr 1:50,783,218...50,872,358 JBrowse link
G Sting1 stimulator of interferon response cGAMP interactor 1 multiple interactions ISO Ethidium inhibits the reaction [cyanoginosin LR results in increased expression of STING1 protein] CTD PMID:35032610 NCBI chr18:27,606,196...27,612,544 JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO Ethidium results in increased expression of TFAM mRNA CTD PMID:22712077 NCBI chr20:17,356,243...17,368,293 JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Ethidium inhibits the reaction [cyanoginosin LR results in increased expression of TNF mRNA] CTD PMID:35032610 NCBI chr20:3,626,685...3,629,303 JBrowse link
G Tp53 tumor protein p53 affects activity ISO Ethidium affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,798,871...54,810,300 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    chemical entity 19896
      molecular entity 19895
        mancude ring 11342
          organic mancude parent 11342
            mancude organic heterocyclic parent 11342
              mancude organic heterotricyclic parent 375
                phenanthridine 23
                  ethidium + 23
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            organic molecule 19724
                              organic cyclic compound 19516
                                organic heterocyclic compound 18896
                                  organic heteropolycyclic compound 18323
                                    organic heterotricyclic compound 15881
                                      dibenzopyridine 175
                                        phenanthridines 59
                                          phenanthridine 23
                                            ethidium + 23
paths to the root