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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chloroquine
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Accession:CHEBI:3638 term browser browse the term
Definition:An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Synonyms:exact_synonym: N(4)-(7-chloroquinolin-4-yl)-N(1),N(1)-diethylpentane-1,4-diamine
 related_synonym: Aralen;   Artrichin;   Bemaphate;   Capquin;   Chlorochin;   Formula=C18H26ClN3;   InChI=1S/C18H26ClN3/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);   InChIKey=WHTVZRBIWZFKQO-UHFFFAOYSA-N;   N(4)-(7-chloro-4-quinolinyl)-N(1),N(1)-diethyl-1,4-pentanediamine;   Nivaquine B;   Resoquine;   Reumachlor;   SMILES=CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12;   Sanoquin;   chloroquinum;   cloroquina
 xref: Beilstein:482809;   CAS:54-05-7;   DrugBank:DB00608;   Drug_Central:607;   Gmelin:781126;   HMDB:HMDB0014746;   KEGG:C07625;   KEGG:D02366;   LINCS:LSM-1901
 xref_mesh: MESH:D002738
 xref: PDBeChem:CLQ;   PMID:11198399;   PMID:17594118;   PMID:18052874;   PMID:19426658;   PMID:23288916;   PMID:23580861;   PMID:23635029;   PMID:23644906;   PMID:23706562;   PMID:23852712;   PMID:23891850;   PMID:25285162;   Patent:DE683692;   Patent:US2233970;   Reaxys:482809;   Wikipedia:Chloroquine
 cyclic_relationship: is_conjugate_base_of CHEBI:149484


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chloroquine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression
multiple interactions
ISO Chloroquine results in decreased expression of ABCB1 mRNA; Chloroquine results in decreased expression of ABCB1 protein
Chloroquine results in decreased expression of ABCB1A mRNA
[Chloroquine co-treated with Bortezomib] results in decreased expression of ABCB1A protein; Bortezomib promotes the reaction [Chloroquine results in decreased expression of ABCB1A mRNA]; Bortezomib promotes the reaction [Chloroquine results in decreased expression of and results in increased nitrosation of ABCB1A protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in decreased expression of ABCB1A protein]; Chloroquine promotes the reaction [Bortezomib results in decreased expression of ABCB1A mRNA]; Chloroquine promotes the reaction [Bortezomib results in decreased expression of and results in increased nitrosation of ABCB1A protein]; Chloroquine results in decreased expression of and results in increased nitrosation of ABCB1A protein; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in decreased expression of ABCB1A protein]]
Bortezomib promotes the reaction [Chloroquine results in decreased expression of ABCB1 mRNA]; Bortezomib promotes the reaction [Chloroquine results in decreased expression of and results in increased nitrosation of ABCB1 protein]; Chloroquine promotes the reaction [Bortezomib results in decreased expression of ABCB1 mRNA]; Chloroquine promotes the reaction [Bortezomib results in decreased expression of and results in increased nitrosation of ABCB1 protein]; Chloroquine promotes the reaction [Cisplatin results in decreased expression of ABCB1 mRNA]; Chloroquine promotes the reaction [Cisplatin results in decreased expression of ABCB1 protein]; Chloroquine results in decreased expression of and results in increased nitrosation of ABCB1 protein
CTD PMID:25987058 PMID:27692344 PMID:30482226 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases expression ISO Chloroquine results in decreased expression of ABCC1 mRNA; Chloroquine results in decreased expression of ABCC1 protein CTD PMID:27692344 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression ISO Chloroquine results in decreased expression of ABCC2 mRNA; Chloroquine results in decreased expression of ABCC2 protein CTD PMID:27692344 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 decreases expression ISO Chloroquine results in decreased expression of ABCG2 mRNA; Chloroquine results in decreased expression of ABCG2 protein CTD PMID:27692344 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO
EXP
Chloroquine inhibits the reaction [formosanin C results in decreased phosphorylation of AKT1 protein]
Chloroquine results in decreased phosphorylation of AKT1 protein
Chloroquine inhibits the reaction [[Diethylnitrosamine co-treated with N-nitrosomorpholine] results in increased expression of and results in increased phosphorylation of AKT1 protein]
CTD PMID:24990399 PMID:27180204 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Akt1s1 AKT1 substrate 1 multiple interactions EXP Chloroquine inhibits the reaction [EGF protein results in increased phosphorylation of AKT1S1 protein] CTD PMID:22689575 NCBI chr 1:100,845,443...100,851,961
Ensembl chr 1:100,845,563...100,851,960
JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 decreases expression EXP Chloroquine results in decreased expression of ALDH1B1 mRNA CTD PMID:19393257 NCBI chr 5:61,382,351...61,387,359
Ensembl chr 5:61,382,351...61,387,358
JBrowse link
G Angptl8 angiopoietin-like 8 multiple interactions ISO Chloroquine inhibits the reaction [ANGPTL8 protein results in decreased expression of SQSTM1 protein] CTD PMID:24262987 NCBI chr 8:22,855,495...22,858,565
Ensembl chr 8:22,856,539...22,858,565
JBrowse link
G Apod apolipoprotein D affects localization ISO Chloroquine affects the localization of APOD protein CTD PMID:28182653 NCBI chr11:72,705,204...72,726,263
Ensembl chr11:72,705,129...72,726,301
JBrowse link
G Apoe apolipoprotein E affects localization EXP Chloroquine affects the localization of APOE protein CTD PMID:8616629 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G App amyloid beta precursor protein affects expression
multiple interactions
affects localization
increases expression
EXP Chloroquine affects the expression of APP mRNA; Chloroquine affects the expression of APP protein
Chloroquine affects the localization of and affects the cleavage of APP protein
Chloroquine affects the localization of APP protein
Chloroquine results in increased expression of APP protein
CTD PMID:7715800 PMID:8616629 PMID:8787835 PMID:9690670 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Appl1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 multiple interactions ISO Chloroquine inhibits the reaction [Lipopolysaccharides results in increased degradation of APPL1 protein]; Chloroquine inhibits the reaction [Poly I-C results in increased degradation of APPL1 protein] CTD PMID:25780039 NCBI chr16:2,560,103...2,602,035
Ensembl chr16:2,563,520...2,602,103
JBrowse link
G Aqp2 aquaporin 2 decreases degradation
multiple interactions
decreases expression
ISO Chloroquine results in decreased degradation of AQP2 protein
Chloroquine inhibits the reaction [AVP protein affects the localization of AQP2 protein]
Chloroquine results in decreased expression of AQP2 protein
CTD PMID:21734099 PMID:22791344 NCBI chr 7:141,237,802...141,242,837
Ensembl chr 7:141,237,768...141,245,165
JBrowse link
G Aqp5 aquaporin 5 multiple interactions ISO Chloroquine inhibits the reaction [Cyclic AMP results in decreased expression of AQP5 protein] CTD PMID:15536076 NCBI chr 7:141,249,044...141,252,576
Ensembl chr 7:141,249,044...141,252,578
JBrowse link
G Ar androgen receptor multiple interactions ISO Chloroquine inhibits the reaction [Riluzole results in increased degradation of and results in decreased expression of AR protein alternative form]; Chloroquine inhibits the reaction [Riluzole results in increased degradation of and results in decreased expression of AR protein] CTD PMID:30280407 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Arcn1 archain 1 affects localization ISO Chloroquine affects the localization of ARCN1 protein CTD PMID:29940786 NCBI chr 8:49,051,257...49,075,861
Ensembl chr 8:49,051,246...49,075,892
JBrowse link
G Ass1 argininosuccinate synthase 1 decreases expression EXP Chloroquine results in decreased expression of ASS1 mRNA CTD PMID:19393257 NCBI chr 3:10,327,411...10,375,847
Ensembl chr 3:10,327,414...10,375,826
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions EXP Chloroquine promotes the reaction [cadmium acetate results in increased expression of ATF4 protein] CTD PMID:29870746 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atg5 autophagy related 5 multiple interactions
increases expression
ISO
EXP
Chloroquine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of ATG5 protein]; Chloroquine promotes the reaction [Arsenic Trioxide results in increased expression of ATG5 protein]
Chloroquine results in increased expression of ATG5 protein
Chloroquine inhibits the reaction [cadmium acetate results in increased expression of ATG5 protein]
CTD PMID:28184909 PMID:29870746 PMID:30338810 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Atm ATM serine/threonine kinase increases phosphorylation ISO Chloroquine results in increased phosphorylation of ATM protein CTD PMID:18089834 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 multiple interactions
increases expression
EXP
ISO
Chloroquine inhibits the reaction [Cadmium Chloride results in decreased expression of ATP1A1 protein]
Chloroquine results in increased expression of ATP1A1 protein
CTD PMID:10506578 PMID:26750564 NCBI chr 2:204,003,742...204,032,023
Ensembl chr 2:204,003,742...204,032,023
JBrowse link
G Avp arginine vasopressin multiple interactions ISO Chloroquine inhibits the reaction [AVP protein affects the localization of AQP2 protein]; Chloroquine inhibits the reaction [AVP protein affects the localization of SLC14A2 protein] CTD PMID:22791344 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP
BAX mutant form inhibits the reaction [Chloroquine results in increased activity of CASP3 protein]
Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in increased expression of BAX protein]]
Chloroquine affects the folding of and results in increased activity of BAX protein; Chloroquine inhibits the reaction [formosanin C results in increased expression of BAX protein]; Chloroquine promotes the reaction [dactolisib affects the folding of and results in increased activity of BAX protein]; dactolisib promotes the reaction [Chloroquine affects the folding of and results in increased activity of BAX protein]
CTD PMID:11589424 PMID:23151917 PMID:27180204 PMID:28713934 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO Chloroquine results in increased expression of BBC3 mRNA CTD PMID:31310755 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP
Chloroquine inhibits the reaction [formosanin C results in decreased expression of BCL2 protein]
Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in decreased expression of BCL2 protein]]
CTD PMID:27180204 PMID:28713934 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
increases expression
ISO BCL2L1 mutant form promotes the reaction [Chloroquine results in increased activity of CASP3 protein]
Chloroquine results in increased expression of BCL2L1 mRNA
CTD PMID:11589424 PMID:31310755 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Becn1 beclin 1 multiple interactions
decreases expression
ISO
EXP
Carboplatin promotes the reaction [Chloroquine results in decreased expression of BECN1 protein]; Chloroquine inhibits the reaction [Cisplatin results in increased expression of BECN1 protein]; Chloroquine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of BECN1 protein]; Chloroquine promotes the reaction [Carboplatin results in decreased expression of BECN1 protein]
Chloroquine promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BECN1 protein]
Chloroquine inhibits the reaction [cadmium acetate results in increased expression of BECN1 protein]
Chloroquine results in decreased expression of BECN1 mRNA; Chloroquine results in decreased expression of BECN1 protein
CTD PMID:25987058 PMID:27692344 PMID:28184909 PMID:29870746 PMID:31862506 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions ISO Chloroquine inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased expression of BGLAP mRNA] CTD PMID:23111315 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO Chloroquine promotes the reaction [sunitinib results in decreased expression of BIRC5 protein]
Chloroquine promotes the reaction [Immunologic Factors results in decreased expression of BIRC5 protein]
CTD PMID:24751611 PMID:27823620 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions
increases expression
ISO vistusertib inhibits the reaction [Chloroquine results in increased expression of BNIP3 protein] CTD PMID:26853465 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Calr calreticulin increases expression
multiple interactions
ISO Chloroquine results in increased expression of CALR mRNA
[CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of and affects the localization of CALR protein]; [CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of CALR mRNA]; [CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [Chloroquine results in increased expression of and affects the localization of CALR protein]; [CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [Chloroquine results in increased expression of CALR mRNA]; [Chloroquine co-treated with Bortezomib] promotes the reaction [CEBPB protein alternative form binds to CALR promoter]; [Chloroquine co-treated with Bortezomib] results in increased expression of and affects the localization of CALR protein; [Chloroquine co-treated with Bortezomib] results in increased expression of CALR mRNA; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of and affects the localization of CALR protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CALR mRNA]; CEBPB protein alternative form promotes the reaction [Chloroquine results in increased expression of and affects the localization of CALR protein]; CEBPB protein alternative form promotes the reaction [Chloroquine results in increased expression of CALR mRNA]; Chloroquine promotes the reaction [CEBPB protein alternative form binds to CALR promoter]; Chloroquine results in increased expression of and affects the localization of CALR protein; DDIT3 protein affects the reaction [[Chloroquine co-treated with Bortezomib] affects the localization of CALR protein]; DDIT3 protein affects the reaction [Chloroquine affects the localization of CALR protein]; Doxorubicin promotes the reaction [[Chloroquine co-treated with Bortezomib] affects the localization of CALR protein]; Doxorubicin promotes the reaction [Chloroquine affects the localization of CALR protein]
[Chloroquine co-treated with Bortezomib] results in increased expression of CALR protein; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CALR protein]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CALR protein]]
CTD PMID:30482226 NCBI chr19:25,956,771...25,961,666
Ensembl chr19:25,956,771...25,961,666
JBrowse link
G Casp12 caspase 12 multiple interactions EXP Chloroquine promotes the reaction [cadmium acetate results in increased expression of CASP12 protein] CTD PMID:29870746 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases expression
increases activity
ISO
EXP
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Chloroquine results in increased cleavage of CASP3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased cleavage of CASP3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased cleavage of CASP3 protein]; [Bortezomib co-treated with Chloroquine] results in increased cleavage of CASP3 protein; [Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein; [Rotenone co-treated with Chloroquine] results in increased cleavage of CASP3 protein; BAX mutant form inhibits the reaction [Chloroquine results in increased activity of CASP3 protein]; BCL2L1 mutant form promotes the reaction [Chloroquine results in increased activity of CASP3 protein]; betulinic acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; Chloroquine inhibits the reaction [Cadmium results in increased cleavage of CASP3 protein]; Chloroquine inhibits the reaction [trichostatin A inhibits the reaction [Cisplatin results in increased expression of CASP3 protein modified form]]; Chloroquine promotes the reaction [Cisplatin results in increased expression of CASP3 protein modified form]; Chloroquine promotes the reaction [Sunitinib results in increased activity of CASP3 protein]; Doxorubicin promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased cleavage of CASP3 protein]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]]; Doxorubicin promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein]; Nitroprusside promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; Nitroprusside promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein]; TRP53 mutant form inhibits the reaction [Chloroquine results in increased activity of CASP3 protein]
Chloroquine inhibits the reaction [3,4-dihydroxyphenylethanol inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]]; Chloroquine inhibits the reaction [trichostatin A inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]]
Chloroquine results in increased expression of CASP3 protein
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Chloroquine results in increased cleavage of CASP3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased cleavage of CASP3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased cleavage of CASP3 protein]; [aloxistatin co-treated with pepstatin] inhibits the reaction [[vistusertib co-treated with Chloroquine] results in increased activity of CASP3 protein]; [Bortezomib co-treated with Chloroquine] results in increased cleavage of CASP3 protein; [capivasertib co-treated with Chloroquine] results in increased activity of CASP3 protein; [Chloroquine co-treated with N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine] results in increased activity of CASP3 protein; [vistusertib co-treated with Chloroquine] results in increased activity of CASP3 protein; betulinic acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; CA 074 methyl ester inhibits the reaction [[capivasertib co-treated with Chloroquine] results in increased activity of CASP3 protein]; CA 074 methyl ester inhibits the reaction [[vistusertib co-treated with Chloroquine] results in increased activity of CASP3 protein]; Chloroquine inhibits the reaction [alpinetin inhibits the reaction [TNF protein results in increased cleavage of CASP3 protein]]; Chloroquine inhibits the reaction [betulin results in increased cleavage of CASP3 protein]; Chloroquine inhibits the reaction [Biological Products results in increased cleavage of CASP3 protein]; Chloroquine inhibits the reaction [Cadmium results in increased cleavage of CASP3 protein]; Chloroquine inhibits the reaction [formosanin C results in increased expression of and results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [Amiodarone results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [Arsenic Trioxide results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [Biological Products results in increased expression of and results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [Cisplatin results in increased expression of CASP3 protein]; Chloroquine promotes the reaction [dactolisib results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [usnic acid results in increased activity of CASP3 protein]; dactolisib promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein]; DDIT3 protein affects the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; DDIT3 protein affects the reaction [Chloroquine results in increased cleavage of CASP3 protein]; Doxorubicin promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; Doxorubicin promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein]; NDRG1 protein affects the reaction [Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of CASP3 protein]]; NDRG1 protein affects the reaction [Chloroquine results in increased cleavage of CASP3 protein]; Nitroprusside promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; Nitroprusside promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein]
CTD PMID:11589424 PMID:23151917 PMID:23799852 PMID:24751611 PMID:25078063 PMID:25266202 PMID:25987058 PMID:26847702 PMID:26853465 PMID:27180204 PMID:28219700 PMID:28906492 PMID:29111403 PMID:29476062 PMID:30338810 PMID:30465897 PMID:30482226 PMID:30985881 PMID:31332898 PMID:31676321 PMID:32190974 PMID:32651653 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions ISO Chloroquine promotes the reaction [usnic acid results in increased activity of CASP7 protein] CTD PMID:25078063 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 increases cleavage
multiple interactions
ISO Chloroquine results in increased cleavage of CASP8 protein
Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of CASP8 protein]
Chloroquine inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein]
CTD PMID:27692344 PMID:28906492 PMID:29111403 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
ISO [Chloroquine co-treated with N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine] results in increased activity of CASP9 protein; Chloroquine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of CASP9 mRNA]; Chloroquine promotes the reaction [dactolisib results in increased cleavage of CASP9 protein]; Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of CASP9 protein]; dactolisib promotes the reaction [Chloroquine results in increased cleavage of CASP9 protein] CTD PMID:23151917 PMID:23799852 PMID:28184909 PMID:28906492 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Casr calcium-sensing receptor multiple interactions EXP Chloroquine inhibits the reaction [Oxygen deficiency results in increased expression of CASR mRNA]; Chloroquine inhibits the reaction [Oxygen deficiency results in increased expression of CASR protein] CTD PMID:32956540 NCBI chr11:67,188,204...67,262,261
Ensembl chr11:67,188,630...67,258,771
JBrowse link
G Cat catalase decreases activity
multiple interactions
decreases expression
EXP
ISO
Chloroquine results in decreased activity of CAT protein
Chloroquine promotes the reaction [sunitinib results in increased activity of CAT protein]; Quercetin inhibits the reaction [Chloroquine results in decreased activity of CAT protein]; Quercetin inhibits the reaction [Chloroquine results in decreased expression of CAT mRNA]
Curcumin inhibits the reaction [Chloroquine results in decreased activity of CAT protein]; tetrahydrocurcumin inhibits the reaction [Chloroquine results in decreased activity of CAT protein]
Chloroquine results in decreased expression of CAT protein
CTD PMID:15526909 PMID:17076682 PMID:23607047 PMID:24751611 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl1 C-C motif chemokine ligand 1 multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL1 protein] CTD PMID:22341560 NCBI chr10:69,534,976...69,537,836
Ensembl chr10:69,534,933...69,537,882
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 decreases secretion
multiple interactions
ISO Chloroquine results in decreased secretion of CCL11 protein
Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL11 protein]
CTD PMID:22341560 PMID:29772762 NCBI chr10:69,434,965...69,439,566
Ensembl chr10:69,434,941...69,439,575
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions
decreases secretion
ISO Chloroquine results in increased expression of CCL2 mRNA
Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL2 protein]
Chloroquine results in decreased secretion of CCL2 protein
Acetylcysteine inhibits the reaction [Chloroquine results in increased expression of CCL2 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Chloroquine results in increased expression of CCL2 mRNA]; diphenyliodonium inhibits the reaction [Chloroquine results in increased expression of CCL2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Chloroquine results in increased expression of CCL2 mRNA]
CTD PMID:15139008 PMID:22341560 PMID:29772762 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl25 C-C motif chemokine ligand 25 multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL25 protein] CTD PMID:22341560 NCBI chr12:2,429,492...2,438,928
Ensembl chr12:2,429,509...2,438,817
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL5 protein] CTD PMID:22341560 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccn1 cellular communication network factor 1 increases expression EXP Chloroquine results in increased expression of CCN1 mRNA CTD PMID:19393257 NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312
JBrowse link
G Cd274 CD274 molecule decreases expression ISO Chloroquine results in decreased expression of CD274 protein CTD PMID:27692344 NCBI chr 1:247,519,890...247,539,659
Ensembl chr 1:247,519,939...247,537,943
JBrowse link
G Cd34 CD34 molecule multiple interactions ISO Chloroquine promotes the reaction [sunitinib results in decreased expression of CD34 protein] CTD PMID:24751611 NCBI chr13:113,691,842...113,711,259
Ensembl chr13:113,691,932...113,711,647
JBrowse link
G Cdh1 cadherin 1 multiple interactions EXP Chloroquine inhibits the reaction [Dibutyl Phthalate results in decreased expression of CDH1 mRNA]; Chloroquine inhibits the reaction [Dibutyl Phthalate results in decreased expression of CDH1 protein] CTD PMID:30053495 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh2 cadherin 2 multiple interactions EXP Chloroquine inhibits the reaction [Dibutyl Phthalate results in increased expression of CDH2 mRNA]; Chloroquine inhibits the reaction [Dibutyl Phthalate results in increased expression of CDH2 protein] CTD PMID:30053495 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases activity
multiple interactions
increases expression
ISO Chloroquine results in increased activity of CDKN1A
[Chloroquine co-treated with flavokawain B] results in decreased expression of CDKN1A protein; Chloroquine inhibits the reaction [Doxorubicin results in increased expression of CDKN1A protein]
Chloroquine results in increased expression of CDKN1A protein
CTD PMID:12243503 PMID:18089834 PMID:22927544 PMID:30025493 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions
increases expression
ISO 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of CEBPB protein alternative form]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased expression of CEBPB protein alternative form]; [Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form; betulinic acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in decreased expression of ABCB1A protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CALR protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of IFNG protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of MKI67 protein]; Doxorubicin promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in decreased expression of ABCB1A protein]]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CALR protein]]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of IFNG protein]]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of MKI67 protein]]; Doxorubicin promotes the reaction [Chloroquine results in increased expression of CEBPB protein alternative form]
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of CEBPB protein alternative form]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of CEBPB protein alternative form]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased expression of CEBPB protein alternative form]; [CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of and affects the localization of CALR protein]; [CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of CALR mRNA]; [CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [Chloroquine results in increased expression of and affects the localization of CALR protein]; [CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [Chloroquine results in increased expression of CALR mRNA]; [Chloroquine co-treated with Bortezomib] promotes the reaction [CEBPB protein alternative form binds to CALR promoter]; [Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form; betulinic acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of and affects the localization of CALR protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CALR mRNA]; CEBPB protein alternative form promotes the reaction [Chloroquine results in increased expression of and affects the localization of CALR protein]; CEBPB protein alternative form promotes the reaction [Chloroquine results in increased expression of CALR mRNA]; Chloroquine promotes the reaction [CEBPB protein alternative form binds to CALR promoter]; Doxorubicin promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form]; Doxorubicin promotes the reaction [Chloroquine results in increased expression of CEBPB protein alternative form]
CTD PMID:30482226 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex decreases expression ISO Chloroquine results in decreased expression of CHUK protein CTD PMID:26116531 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Cip2a cellular inhibitor of PP2A multiple interactions ISO Chloroquine inhibits the reaction [temsirolimus results in decreased expression of CIP2A protein] CTD PMID:24493623 NCBI chr11:54,373,794...54,404,704
Ensembl chr11:54,377,374...54,404,612
JBrowse link
G Cldn1 claudin 1 increases expression ISO Chloroquine results in increased expression of CLDN1 mRNA CTD PMID:25752684 NCBI chr11:77,815,216...77,830,373
Ensembl chr11:77,815,181...77,830,416
JBrowse link
G Cldn2 claudin 2 multiple interactions ISO Chloroquine inhibits the reaction [caffeic acid phenethyl ester results in decreased expression of CLDN2 protein] CTD PMID:29597147 NCBI chr  X:111,122,552...111,133,188
Ensembl chr  X:111,122,552...111,137,769
JBrowse link
G Clu clusterin affects localization EXP Chloroquine affects the localization of CLU protein CTD PMID:8616629 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Coq6 coenzyme Q6 monooxygenase decreases expression EXP Chloroquine results in decreased expression of COQ6 mRNA CTD PMID:19393257 NCBI chr 6:108,076,393...108,087,782
Ensembl chr 6:108,076,306...108,087,696
JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 multiple interactions ISO Chloroquine promotes the reaction [Triiodothyronine results in increased expression of COX4I1 protein] CTD PMID:30209975 NCBI chr19:54,245,958...54,252,198
Ensembl chr19:54,245,950...54,252,225
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP Chloroquine inhibits the reaction [Dibutyl Phthalate results in increased expression of CTNNB1 mRNA] CTD PMID:30053495 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Ctsa cathepsin A multiple interactions ISO [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of CTSA protein CTD PMID:30821613 NCBI chr 3:161,298,750...161,304,627
Ensembl chr 3:161,298,962...161,304,625
JBrowse link
G Ctsb cathepsin B increases expression
decreases activity
multiple interactions
EXP
ISO
Chloroquine results in increased expression of CTSB protein
Chloroquine results in decreased activity of CTSB protein
[Chloroquine co-treated with dactolisib] affects the localization of CTSB protein; [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of CTSB protein; Chloroquine inhibits the reaction [Arsenic Trioxide results in increased activity of CTSB protein]
CTD PMID:2759144 PMID:23151917 PMID:30338810 PMID:30821613 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Ctsd cathepsin D affects localization
multiple interactions
increases expression
EXP
ISO
Chloroquine affects the localization of CTSD protein
[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of CTSD protein
Chloroquine results in increased expression of CTSD protein
CTD PMID:2759144 PMID:7715800 PMID:30821613 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Ctsl cathepsin L increases expression EXP Chloroquine results in increased expression of CTSL protein CTD PMID:2759144 NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Chloroquine inhibits the reaction [CpG ODN 2216 results in increased expression of CXCL10 protein]; Chloroquine inhibits the reaction [gardiquimod results in increased expression of CXCL10 protein]; Chloroquine inhibits the reaction [Poly I-C results in increased expression of CXCL10 protein] CTD PMID:26682054 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CXCL12 protein] CTD PMID:22341560 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CXCL9 protein] CTD PMID:22341560 NCBI chr14:17,228,832...17,233,743
Ensembl chr14:17,228,856...17,234,712
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression EXP Chloroquine results in decreased expression of CYP11A1 mRNA CTD PMID:19393257 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression EXP Chloroquine results in decreased expression of CYP17A1 mRNA CTD PMID:19393257 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO Chloroquine inhibits the reaction [CYP1A2 protein results in increased metabolism of Tacrine] CTD PMID:7946932 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 affects metabolic processing
multiple interactions
increases metabolic processing
ISO CYP2C8 polymorphism affects the metabolism of Chloroquine; CYP2C8 protein affects the metabolism of Chloroquine
[CYP2C8 protein results in increased metabolism of Chloroquine] which results in increased abundance of desethylchloroquine; Quercetin inhibits the reaction [[CYP2C8 protein results in increased metabolism of Chloroquine] which results in increased abundance of desethylchloroquine]
CTD PMID:12756207 PMID:12920490 PMID:12967198 PMID:17286541 PMID:19560616 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing
decreases activity
multiple interactions
ISO CYP2D6 protein affects the metabolism of Chloroquine
Chloroquine results in decreased activity of CYP2D6 protein
[CYP2D6 protein results in increased metabolism of Chloroquine] which results in increased abundance of desethylchloroquine
CTD PMID:12756207 PMID:12920490 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity
multiple interactions
affects metabolic processing
ISO Chloroquine results in decreased activity of CYP3A4 protein
[CYP3A4 protein results in increased metabolism of Chloroquine] which results in increased abundance of desethylchloroquine
CYP3A4 protein affects the metabolism of Chloroquine
CTD PMID:11124226 PMID:12756207 PMID:12920490 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO Chloroquine promotes the reaction [CYP7A1 protein results in increased expression of MAP1LC3B protein modified form]; CYP7A1 mRNA promotes the reaction [Chloroquine results in increased expression of MAP1LC3B protein modified form] CTD PMID:28275691 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
EXP
ISO
Chloroquine promotes the reaction [cadmium acetate results in increased expression of DDIT3 protein]; Chloroquine promotes the reaction [Cadmium results in increased expression of DDIT3 protein]
Chloroquine results in increased expression of DDIT3 protein
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of DDIT3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased expression of DDIT3 protein]; [Bortezomib co-treated with Chloroquine] results in increased expression of DDIT3 protein; betulinic acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; DDIT3 protein affects the reaction [[Chloroquine co-treated with Bortezomib] affects the localization of CALR protein]; DDIT3 protein affects the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; DDIT3 protein affects the reaction [Chloroquine affects the localization of CALR protein]; DDIT3 protein affects the reaction [Chloroquine results in increased cleavage of CASP3 protein]; Doxorubicin promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of DDIT3 protein]; Doxorubicin promotes the reaction [Chloroquine results in increased expression of DDIT3 protein]; Nitroprusside promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; Nitroprusside promotes the reaction [Chloroquine results in increased expression of DDIT3 protein]
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of DDIT3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased expression of DDIT3 protein]; [Bortezomib co-treated with Chloroquine] results in increased expression of DDIT3 protein; [Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein; betulinic acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; Doxorubicin promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of DDIT3 protein]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]]; Doxorubicin promotes the reaction [Chloroquine results in increased expression of DDIT3 protein]; Nitroprusside inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; Nitroprusside inhibits the reaction [Chloroquine results in increased expression of DDIT3 protein]
CTD PMID:27658547 PMID:29870746 PMID:30482226 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked multiple interactions ISO [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of DDX3X protein; Chloroquine inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of DDX3X protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of DDX3X protein] CTD PMID:30821613 NCBI chr  X:10,400,363...10,414,010
Ensembl chr  X:10,400,366...10,413,995
JBrowse link
G Eea1 early endosome antigen 1 affects localization ISO Chloroquine affects the localization of EEA1 protein CTD PMID:29940786 NCBI chr 7:37,101,415...37,186,534
Ensembl chr 7:37,018,459...37,186,732
JBrowse link
G Egf epidermal growth factor multiple interactions ISO
EXP
Chloroquine inhibits the reaction [EGF protein results in decreased expression of EGFR protein]
Chloroquine inhibits the reaction [EGF protein results in increased expression of RHEB protein]; Chloroquine inhibits the reaction [EGF protein results in increased phosphorylation of AKT1S1 protein]; Chloroquine inhibits the reaction [EGF protein results in increased phosphorylation of EIF4EBP1 protein]; Chloroquine inhibits the reaction [EGF protein results in increased phosphorylation of RPS6KB1 protein]; Chloroquine promotes the reaction [EGF protein results in increased expression of and results in increased phosphorylation of EGFR protein]
CTD PMID:20332299 PMID:22689575 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases expression
ISO
EXP
Chloroquine inhibits the reaction [EGF protein results in decreased expression of EGFR protein]; Chloroquine inhibits the reaction [MUC1 affects the expression of EGFR protein]; Chloroquine inhibits the reaction [sulindac sulfide results in decreased expression of EGFR protein]; Chloroquine inhibits the reaction [sulindac sulfone results in decreased expression of EGFR protein]; Chloroquine inhibits the reaction [tephrosin results in increased degradation of EGFR protein]
Chloroquine promotes the reaction [EGF protein results in increased expression of and results in increased phosphorylation of EGFR protein]
Chloroquine results in decreased expression of EGFR protein
CTD PMID:20056314 PMID:20332299 PMID:22457794 PMID:22689575 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Eif4a1 eukaryotic translation initiation factor 4A1 multiple interactions ISO [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of EIF4A1 protein; Chloroquine inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of EIF4A1 protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of EIF4A1 protein] CTD PMID:30821613 NCBI chr10:56,271,257...56,276,764
Ensembl chr10:56,271,257...56,276,764
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions EXP Chloroquine inhibits the reaction [EGF protein results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:22689575 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Eif4h eukaryotic translation initiation factor 4H multiple interactions ISO [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of EIF4H protein; Chloroquine inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of EIF4H protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of EIF4H protein] CTD PMID:30821613 NCBI chr12:25,093,119...25,109,805
Ensembl chr12:25,093,149...25,109,799
JBrowse link
G Eno2 enolase 2 multiple interactions EXP Chloroquine inhibits the reaction [Sirolimus results in increased expression of ENO2 protein] CTD PMID:26676567 NCBI chr 4:157,285,192...157,294,090
Ensembl chr 4:157,285,179...157,294,047
Ensembl chr 9:157,285,179...157,294,047
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 decreases expression
multiple interactions
ISO Chloroquine results in decreased expression of ERBB2 protein
Chloroquine inhibits the reaction [tephrosin results in increased degradation of ERBB2 protein]
CTD PMID:20056314 PMID:20332299 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 decreases expression ISO Chloroquine results in decreased expression of ERBB3 protein CTD PMID:20332299 NCBI chr 7:2,989,202...3,010,610
Ensembl chr 7:2,989,340...3,010,350
JBrowse link
G Ergic3 ERGIC and golgi 3 multiple interactions ISO ERGIC3 protein promotes the reaction [Chloroquine results in increased expression of SQSTM1 protein] CTD PMID:27588471 NCBI chr 3:151,553,567...151,563,318
Ensembl chr 3:151,553,578...151,563,364
JBrowse link
G Fads2 fatty acid desaturase 2 decreases expression EXP Chloroquine results in decreased expression of FADS2 mRNA CTD PMID:19393257 NCBI chr 1:225,906,582...226,152,568
Ensembl chr 1:226,114,413...226,152,524
JBrowse link
G Faslg Fas ligand multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of FASL protein] CTD PMID:22341560 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fbxo32 F-box protein 32 affects expression EXP Chloroquine affects the expression of FBXO32 mRNA CTD PMID:19296457 NCBI chr 7:98,065,664...98,098,071
Ensembl chr 7:98,063,735...98,098,268
JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions EXP Chloroquine inhibits the reaction [3,4-dihydroxyphenylethanol inhibits the reaction [Hydrogen Peroxide results in decreased expression of FGF1 mRNA]] CTD PMID:31332898 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Fmn1 formin 1 decreases expression EXP Chloroquine results in decreased expression of FMN1 mRNA CTD PMID:19393257 NCBI chr 3:104,783,093...105,170,761
Ensembl chr 3:104,816,987...105,086,436
JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions
increases expression
ISO
EXP
Chloroquine inhibits the reaction [Artesunate results in decreased expression of FTH1 mRNA]
Chloroquine promotes the reaction [erastin results in increased expression of FTH1 protein]
Chloroquine results in increased expression of FTH1 mRNA
CTD PMID:30551460 PMID:32937103 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G Fundc1 FUN14 domain containing 1 multiple interactions ISO Chloroquine inhibits the reaction [Rotenone results in decreased expression of FUNDC1 protein] CTD PMID:32001317 NCBI chr  X:5,549,468...5,566,125
Ensembl chr  X:5,549,419...5,566,127
JBrowse link
G Gal3st1 galactose-3-O-sulfotransferase 1 multiple interactions ISO GAL3ST1 protein affects the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein] CTD PMID:23880069 NCBI chr14:84,231,473...84,247,371
Ensembl chr14:84,231,639...84,247,369
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP
ISO
Chloroquine inhibits the reaction [DDT results in increased degradation of GJA1 protein modified form]; Chloroquine inhibits the reaction [Hexachlorocyclohexane results in increased degradation of GJA1 protein modified form]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in increased expression of GJA1 protein]]; Chloroquine promotes the reaction [Glucose results in increased expression of GJA1 protein]
Chloroquine inhibits the reaction [LAMB1 protein affects the localization of GJA1 protein]
CTD PMID:8824497 PMID:22150760 PMID:28713934 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gjb2 gap junction protein, beta 2 decreases expression EXP Chloroquine results in decreased expression of GJB2 mRNA CTD PMID:19393257 NCBI chr15:37,377,313...37,394,494
Ensembl chr15:37,377,316...37,383,277
JBrowse link
G Glb1 galactosidase, beta 1 multiple interactions ISO [Chloroquine co-treated with flavokawain B] results in decreased expression of GLB1 protein CTD PMID:30025493 NCBI chr 8:122,439,328...122,511,939
Ensembl chr 8:122,439,328...122,511,939
JBrowse link
G Glp1r glucagon-like peptide 1 receptor multiple interactions EXP Chloroquine inhibits the reaction [Oleic Acid results in increased degradation of and results in decreased expression of GLP1R protein] CTD PMID:22925809 NCBI chr20:9,586,075...9,626,228
Ensembl chr20:9,586,075...9,626,228
JBrowse link
G Golga2 golgin A2 affects localization ISO Chloroquine affects the localization of GOLGA2 protein CTD PMID:29940786 NCBI chr 3:11,317,328...11,337,569
Ensembl chr 3:11,317,183...11,336,458
JBrowse link
G Gpnmb glycoprotein nmb increases expression EXP Chloroquine results in increased expression of GPNMB mRNA CTD PMID:19393257 NCBI chr 4:78,694,447...78,715,685
Ensembl chr 4:78,694,447...78,715,683
JBrowse link
G Gpr182 G protein-coupled receptor 182 decreases expression EXP Chloroquine results in decreased expression of GPR182 mRNA CTD PMID:19393257 NCBI chr 7:71,044,786...71,048,713
Ensembl chr 7:71,045,543...71,048,383
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Chloroquine inhibits the reaction [resveratrol inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased activity of GPT protein]]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased activity of GPT protein] CTD PMID:26498332 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx4 glutathione peroxidase 4 decreases expression
multiple interactions
ISO Chloroquine results in decreased expression of GPX4 mRNA
Quercetin inhibits the reaction [Chloroquine results in decreased expression of GPX4 mRNA]
CTD PMID:23607047 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions EXP Chloroquine inhibits the reaction [Nanotubes, Carbon results in decreased expression of GRIN2B] CTD PMID:26327526 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity
decreases expression
multiple interactions
ISO Chloroquine results in decreased activity of GSR protein
Chloroquine results in decreased expression of GSR mRNA
Quercetin inhibits the reaction [Chloroquine results in decreased activity of GSR protein]; Quercetin inhibits the reaction [Chloroquine results in decreased expression of GSR mRNA]
CTD PMID:23607047 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hbg1 hemoglobin subunit gamma 1 decreases expression EXP Chloroquine results in decreased expression of HBG1 mRNA CTD PMID:19393257 NCBI chr 1:168,992,841...168,994,219
Ensembl chr 1:168,992,722...168,994,253
JBrowse link
G Hk2 hexokinase 2 multiple interactions ISO [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of HK2 protein; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of HK2 protein] CTD PMID:30821613 NCBI chr 4:113,559,396...113,609,897
Ensembl chr 4:113,559,427...113,610,243
JBrowse link
G Hmbs hydroxymethylbilane synthase increases response to substance ISO HMBS mutant form results in increased susceptibility to Chloroquine CTD PMID:8772850 NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B multiple interactions ISO Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased expression of HSPA1B protein] CTD PMID:17046822 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Chloroquine promotes the reaction [cadmium acetate results in increased expression of HSPA5 protein] CTD PMID:29870746 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 multiple interactions ISO [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of HSPA8 protein alternative form CTD PMID:30821613 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Chloroquine inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]] CTD PMID:24145604 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNB1 mRNA]; Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNB1 protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNB1 mRNA]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNB1 protein]] CTD PMID:28134560 NCBI chr 5:106,865,192...106,865,746
Ensembl chr 5:106,865,192...106,865,746
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Chloroquine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA
[Chloroquine co-treated with Bortezomib] results in increased expression of IFNG protein; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of IFNG protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IFNG protein]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of IFNG protein]]
CTD PMID:22341560 PMID:29594315 PMID:30482226 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta decreases expression ISO Chloroquine results in decreased expression of IKBKB protein CTD PMID:26116531 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma decreases expression ISO Chloroquine results in decreased expression of IKBKG protein CTD PMID:26116531 NCBI chr  X:156,254,187...156,280,046
Ensembl chr  X:156,257,173...156,270,748
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL10 protein] CTD PMID:22341560 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il13 interleukin 13 multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL13 protein] CTD PMID:22341560 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il17a interleukin 17A multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL17A protein] CTD PMID:22341560 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il1a interleukin 1 alpha increases expression
multiple interactions
ISO Chloroquine results in increased expression of IL1A
Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1A protein]
CTD PMID:15139008 PMID:22341560 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta increases expression
decreases expression
multiple interactions
ISO Chloroquine results in increased expression of IL1B
Chloroquine results in decreased expression of IL1B mRNA
Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL1B protein]]; Chloroquine inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL1B mRNA]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL1B protein]
Chloroquine inhibits the reaction [Rifampin inhibits the reaction [Rotenone results in increased expression of IL1B mRNA]]; Chloroquine inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]
CTD PMID:15139008 PMID:21051542 PMID:22341560 PMID:26498332 PMID:29594315 PMID:31648047 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 decreases expression
multiple interactions
ISO Chloroquine results in decreased expression of IL2 mRNA; Chloroquine results in decreased expression of IL2 protein
Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL2 protein]
[Chloroquine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA
CTD PMID:7554381 PMID:22341560 PMID:29594315 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il3 interleukin 3 multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL3 protein] CTD PMID:22341560 NCBI chr10:39,620,535...39,622,973
Ensembl chr10:39,620,563...39,622,973
JBrowse link
G Il4 interleukin 4 multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL4 protein] CTD PMID:22341560 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
decreases secretion
increases expression
ISO
EXP
Chloroquine results in decreased expression of IL6 protein
Chloroquine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Chloroquine inhibits the reaction [Rifampin inhibits the reaction [Rotenone results in increased expression of IL6 mRNA]]
Chloroquine results in decreased secretion of IL6 protein
Chloroquine inhibits the reaction [3,4-dihydroxyphenylethanol inhibits the reaction [Hydrogen Peroxide results in increased secretion of IL6 protein]]
[Chloroquine co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL6 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Chloroquine co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL6 protein]; Bortezomib inhibits the reaction [[Chloroquine co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL6 protein]; Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased secretion of IL6 protein]; Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]; Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL6 protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL6 protein]]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL6 mRNA]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL6 protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL6 protein]]
Chloroquine results in increased expression of IL6
CTD PMID:9002011 PMID:9799232 PMID:10638776 PMID:15139008 PMID:22341560 PMID:26498332 PMID:28134560 PMID:29772762 PMID:31332898 PMID:31648047 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of IRF3 protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased degradation of IRF3 protein]; Chloroquine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRF3 protein]; Chloroquine inhibits the reaction [Poly I-C results in increased phosphorylation of IRF3 protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of IRF3 protein]] CTD PMID:22341560 PMID:25780039 PMID:28134560 NCBI chr 1:100,992,244...100,997,202
Ensembl chr 1:100,992,405...100,997,198
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO [benzyloxycarbonyl-valyl-alanyl-aspartic acid analog co-treated with Chloroquine] inhibits the reaction [Tretinoin affects the localization of ITGAM protein]; Chloroquine inhibits the reaction [Tretinoin affects the localization of ITGAM protein] CTD PMID:29743969 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Lamb1 laminin subunit beta 1 multiple interactions ISO Chloroquine inhibits the reaction [LAMB1 protein affects the localization of GJA1 protein] CTD PMID:22150760 NCBI chr 6:50,528,796...50,596,593
Ensembl chr 6:50,528,823...50,596,079
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 multiple interactions ISO [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of LAMP2 protein; [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of LAMP2 protein alternative form; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of DDX3X protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of EIF4A1 protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of EIF4H protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of HK2 protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of LAMP2 protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of NFKBIA protein] CTD PMID:30821613 NCBI chr  X:124,722,628...124,766,079
Ensembl chr  X:124,722,628...124,766,044
JBrowse link
G Lcn2 lipocalin 2 increases expression EXP Chloroquine results in increased expression of LCN2 mRNA CTD PMID:19393257 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions ISO Chloroquine affects the reaction [SORT1 protein affects the reaction [LDLR protein affects the abundance of Cholesterol]] CTD PMID:30950489 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Lep leptin multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of LEP protein] CTD PMID:22341560 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lepr leptin receptor increases expression ISO Chloroquine results in increased expression of LEPR protein CTD PMID:31199479 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G LOC299277 similar to serine (or cysteine) peptidase inhibitor, clade A, member 3B affects localization EXP Chloroquine affects the localization of SERPINA3 protein CTD PMID:8616629 NCBI chr 6:127,871,895...127,888,287
Ensembl chr 6:127,872,666...127,886,540
JBrowse link
G Ltb lymphotoxin beta increases expression ISO Chloroquine results in increased expression of LTB CTD PMID:15139008 NCBI chr20:5,184,631...5,186,476
Ensembl chr20:5,184,515...5,186,503
Ensembl chr20:5,184,515...5,186,503
JBrowse link
G M6pr mannose-6-phosphate receptor, cation dependent affects expression
affects localization
EXP
ISO
Chloroquine affects the expression of M6PR mRNA
Chloroquine affects the localization of M6PR protein
CTD PMID:15712280 PMID:29940786 NCBI chr 4:155,084,755...155,093,896
Ensembl chr 4:155,088,317...155,092,827
Ensembl chr  X:155,088,317...155,092,827
JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha increases expression ISO Chloroquine results in increased expression of MAP1LC3A protein; Chloroquine results in increased expression of MAP1LC3A protein modified form CTD PMID:30280407 PMID:30871063 NCBI chr 3:150,801,289...150,802,935
Ensembl chr 3:150,801,289...150,802,935
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression
increases lipidation
multiple interactions
affects localization
increases cleavage
EXP
ISO
Chloroquine results in increased expression of MAP1LC3B mRNA; Chloroquine results in increased expression of MAP1LC3B protein; Chloroquine results in increased expression of MAP1LC3B protein modified form
Chloroquine results in increased lipidation of MAP1LC3B protein
Chloroquine promotes the reaction [Cisplatin results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [erastin results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [trichostatin A results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [Vorinostat results in increased expression of MAP1LC3B protein modified form]
Chloroquine affects the localization of MAP1LC3B protein
Chloroquine results in increased cleavage of MAP1LC3B protein
[Ethanol co-treated with Chloroquine] results in increased lipidation of MAP1LC3B protein; Chloroquine inhibits the reaction [VCP protein mutant form results in decreased expression of MAP1LC3B protein]; Chloroquine promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased lipidation of MAP1LC3B protein]; MJN110 affects the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]
[Chloroquine co-treated with flavokawain B] results in increased expression of MAP1LC3B protein modified form; [Chloroquine co-treated with TNF protein] results in increased expression of MAP1LC3B protein alternative form; bafilomycin A1 inhibits the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; Chloroquine affects the reaction [NDRG1 protein affects the lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline affects the localization of MAP1LC3B protein]; Chloroquine promotes the reaction [[Simvastatin co-treated with Metformin] results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [[TNF protein co-treated with Resveratrol] results in increased expression of MAP1LC3B protein alternative form]; Chloroquine promotes the reaction [Arsenic Trioxide results in increased expression of MAP1LC3B protein]; Chloroquine promotes the reaction [CYP7A1 protein results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [Ethanol results in increased expression of MAP1LC3B protein]; Chloroquine promotes the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [fosbretabulin results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [Rifampin results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [YM 155 results in increased lipidation of MAP1LC3B protein]; Chloroquine results in increased lipidation of and results in increased cleavage of MAP1LC3B protein; cryptotanshinone promotes the reaction [Chloroquine results in increased expression of MAP1LC3B protein]; CYP7A1 mRNA promotes the reaction [Chloroquine results in increased expression of MAP1LC3B protein modified form]; GAL3ST1 protein affects the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; NDRG1 protein affects the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; NOD2 protein affects the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; Paraquat inhibits the reaction [Chloroquine results in increased expression of MAP1LC3B protein modified form]
CTD PMID:17643062 PMID:23880069 PMID:24095927 PMID:24145604 PMID:24161432 PMID:24492484 PMID:25412314 PMID:25884947 PMID:26409479 PMID:28275691 PMID:28600121 PMID:28722353 PMID:28906492 PMID:29248574 PMID:29476062 PMID:30025493 PMID:30208301 PMID:30237538 PMID:30301768 PMID:30338810 PMID:31310755 PMID:31586597 PMID:31648047 PMID:31837377 PMID:31862506 PMID:32937103 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions EXP Chloroquine inhibits the reaction [Sirolimus results in increased expression of MAP2 protein] CTD PMID:26676567 NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO Chloroquine results in increased phosphorylation of MAPK1 protein
Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK1 protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK1 protein]]
CTD PMID:18055026 PMID:22341560 PMID:28134560 PMID:31310755 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK3 protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK3 protein]]
Chloroquine results in increased phosphorylation of MAPK3 protein
CTD PMID:18055026 PMID:22341560 PMID:28134560 PMID:31310755 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK8 protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK8 protein]]
Chloroquine inhibits the reaction [Rifampin inhibits the reaction [Rotenone results in increased phosphorylation of MAPK8 protein]]; Chloroquine promotes the reaction [Rotenone results in increased phosphorylation of MAPK8 protein]
CTD PMID:22341560 PMID:28134560 PMID:31648047 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapt microtubule-associated protein tau affects expression
multiple interactions
EXP Chloroquine affects the expression of MAPT mRNA; Chloroquine affects the expression of MAPT protein
Chloroquine affects the localization of and affects the degradation of MAPT protein
CTD PMID:9690670 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions ISO Chloroquine promotes the reaction [usnic acid results in decreased expression of MCL1 protein] CTD PMID:25078063 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mir155 microRNA 155 multiple interactions ISO [Carboplatin co-treated with Chloroquine] results in increased expression of MIR155 mRNA CTD PMID:27692344 NCBI chr11:24,176,603...24,176,667
Ensembl chr11:24,176,603...24,176,667
JBrowse link
G Mir224 microRNA 224 ISO inhibits the reaction [Amiodarone decreased expression of miR224 in a human hepatoma cell line] RGD PMID:23913306 RGD:18182923 NCBI chr  X:152,223,754...152,223,835
Ensembl chr  X:152,223,754...152,223,835
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO [Chloroquine co-treated with flavokawain B] results in decreased expression of MKI67 protein
[Chloroquine co-treated with Bortezomib] results in increased expression of MKI67 protein; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of MKI67 protein]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of MKI67 protein]]
CTD PMID:30025493 PMID:30482226 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions
increases expression
ISO Oxygen deficiency promotes the reaction [Chloroquine results in increased expression of MMP13 mRNA]; TLR9 protein promotes the reaction [Oxygen deficiency promotes the reaction [Chloroquine results in increased expression of MMP13 mRNA]]
Chloroquine results in increased expression of MMP13 mRNA; Chloroquine results in increased expression of MMP13 protein
Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased expression of MMP13 mRNA]; Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased secretion of MMP13 protein]
CTD PMID:23331101 PMID:24273604 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO Chloroquine results in decreased expression of MMP2 mRNA; Chloroquine results in decreased expression of MMP2 protein CTD PMID:24273604 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
increases expression
decreases expression
ISO Chloroquine inhibits the reaction [Artesunate results in decreased expression of MMP9 mRNA]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; Oxygen deficiency inhibits the reaction [Chloroquine results in decreased expression of MMP9 mRNA]
Chloroquine results in increased expression of MMP9 mRNA
Chloroquine results in decreased expression of MMP9 mRNA; Chloroquine results in decreased expression of MMP9 protein
CTD PMID:24145604 PMID:24273604 PMID:30551460 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation
increases expression
ISO Chloroquine inhibits the reaction [formosanin C results in decreased phosphorylation of MTOR protein]
Chloroquine results in decreased phosphorylation of MTOR protein
Chloroquine results in increased expression of MTOR protein
CTD PMID:25884947 PMID:27180204 PMID:31310755 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Muc1 mucin 1, cell surface associated multiple interactions ISO Chloroquine inhibits the reaction [MUC1 affects the expression of EGFR protein] CTD PMID:22457794 NCBI chr 2:188,543,137...188,547,874
Ensembl chr 2:188,543,137...188,547,874
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of MYD88 mRNA] CTD PMID:22341560 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Myom2 myomesin 2 increases expression EXP Chloroquine results in increased expression of MYOM2 mRNA CTD PMID:19393257 NCBI chr16:79,587,136...79,672,871
Ensembl chr16:79,587,640...79,671,719
JBrowse link
G Nacc1 nucleus accumbens associated 1 multiple interactions ISO Chloroquine affects the reaction [NACC1 affects the susceptibility to Cisplatin] CTD PMID:21743489 NCBI chr19:25,783,686...25,801,526
Ensembl chr19:25,783,900...25,801,526
JBrowse link
G Ncoa4 nuclear receptor coactivator 4 multiple interactions
increases expression
ISO
EXP
Chloroquine inhibits the reaction [Artesunate results in decreased expression of NCOA4 mRNA]
Chloroquine inhibits the reaction [erastin results in decreased expression of NCOA4 protein]
Chloroquine results in increased expression of NCOA4 mRNA
CTD PMID:30551460 PMID:32937103 NCBI chr16:8,302,950...8,323,294
Ensembl chr16:8,302,950...8,323,293
JBrowse link
G Ndrg1 N-myc downstream regulated 1 multiple interactions ISO Chloroquine affects the reaction [NDRG1 protein affects the lipidation of MAP1LC3B protein]; Chloroquine inhibits the reaction [Cycloheximide results in decreased expression of NDRG1 protein]; Chloroquine promotes the reaction [fosbretabulin results in increased expression of NDRG1 protein]; NDRG1 protein affects the reaction [Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of CASP3 protein]]; NDRG1 protein affects the reaction [Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of PARP1 protein]]; NDRG1 protein affects the reaction [Chloroquine results in increased cleavage of CASP3 protein]; NDRG1 protein affects the reaction [Chloroquine results in increased cleavage of PARP1 protein]; NDRG1 protein affects the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; NDRG1 protein affects the susceptibility to [fosbretabulin co-treated with Chloroquine] CTD PMID:28906492 NCBI chr 7:107,734,326...107,775,701
Ensembl chr 7:107,734,323...107,775,714
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression
multiple interactions
ISO Chloroquine results in decreased expression of NFKB1 protein
Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased activity of NFKB1 protein]
CTD PMID:22341560 PMID:26116531 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein]]
[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of NFKBIA protein; Chloroquine inhibits the reaction [Bortezomib results in increased degradation of NFKBIA protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of NFKBIA protein]
CTD PMID:24085292 PMID:28134560 PMID:30821613 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 multiple interactions ISO NOD2 protein affects the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein] CTD PMID:23880069 NCBI chr19:19,342,061...19,389,366
Ensembl chr19:19,332,594...19,377,492
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Chloroquine promotes the reaction [sunitinib results in increased expression of NOS2 protein] CTD PMID:24751611 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Notch1 notch receptor 1 multiple interactions ISO [Fluorouracil co-treated with Chloroquine] results in increased expression of NOTCH1 protein CTD PMID:29917191 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Nppc natriuretic peptide C decreases expression EXP Chloroquine results in decreased expression of NPPC mRNA CTD PMID:19393257 NCBI chr 9:93,731,436...93,735,636
Ensembl chr 9:93,731,436...93,735,636
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone reductase 2 multiple interactions ISO Chloroquine binds to and results in decreased activity of NQO2 protein CTD PMID:15078100 NCBI chr17:32,131,847...32,158,559
Ensembl chr17:32,132,347...32,158,538
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression ISO Chloroquine results in decreased expression of NR0B2 mRNA CTD PMID:24189133 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 multiple interactions ISO Chloroquine binds to and results in increased activity of NR4A2 protein CTD PMID:31175960 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159
JBrowse link
G Ocln occludin increases expression ISO Chloroquine results in increased expression of OCLN mRNA CTD PMID:25752684 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
JBrowse link
G Optn optineurin multiple interactions ISO Chloroquine inhibits the reaction [VCP protein mutant form results in increased expression of OPTN protein] CTD PMID:25884947 NCBI chr17:77,167,700...77,218,374
Ensembl chr17:77,167,740...77,218,389
JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 decreases expression EXP Chloroquine results in decreased expression of OSGIN1 mRNA CTD PMID:19393257 NCBI chr19:52,056,808...52,085,491
Ensembl chr19:52,077,109...52,085,496
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
EXP
ISO
Chloroquine promotes the reaction [Cadmium results in increased cleavage of PARP1 protein]
Chloroquine results in increased cleavage of PARP1 protein
[Chloroquine co-treated with 3-methyladenine] results in increased cleavage of PARP1 protein; Arsenic Trioxide promotes the reaction [Chloroquine results in increased cleavage of PARP1 protein]; Chloroquine inhibits the reaction [betulin results in increased cleavage of PARP1 protein]; Chloroquine inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]; Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of PARP1 protein]; NDRG1 protein affects the reaction [Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of PARP1 protein]]; NDRG1 protein affects the reaction [Chloroquine results in increased cleavage of PARP1 protein]
CTD PMID:27658547 PMID:28906492 PMID:29111403 PMID:30025493 PMID:30338810 PMID:30985881 PMID:31310755 PMID:32190974 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Plin3 perilipin 3 multiple interactions ISO Chloroquine inhibits the reaction [CpG ODN 1826 results in increased expression of PLIN3 mRNA]; Chloroquine inhibits the reaction [CpG ODN 1826 results in increased expression of PLIN3 protein] CTD PMID:20628022 NCBI chr 9:10,769,739...10,781,659
Ensembl chr 9:10,773,901...10,781,109
JBrowse link
G Pomc proopiomelanocortin multiple interactions EXP Chloroquine inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Adrenal Cortex Hormones] CTD PMID:2993719 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 multiple interactions ISO Chloroquine analog binds to and results in decreased activity of PPT1 protein; Chloroquine binds to and results in decreased activity of PPT1 protein CTD PMID:30442709 NCBI chr 5:140,538,260...140,558,163
Ensembl chr 5:140,538,260...140,558,162
JBrowse link
G Prlr prolactin receptor decreases expression EXP Chloroquine results in decreased expression of PRLR mRNA CTD PMID:19393257 NCBI chr 2:60,131,410...60,325,686
Ensembl chr 2:60,131,776...60,325,692
JBrowse link
G Pten phosphatase and tensin homolog increases expression ISO Chloroquine results in increased expression of PTEN mRNA CTD PMID:31310755 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Chloroquine inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]] CTD PMID:24145604 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region increases expression ISO Chloroquine results in increased expression of RBPJ protein CTD PMID:22302987 NCBI chr14:59,657,738...59,865,427
Ensembl chr14:59,658,935...59,735,450
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression
increases activity
ISO
EXP
Acetylcysteine inhibits the reaction [Chloroquine results in increased activity of RELA protein]; diphenyliodonium inhibits the reaction [Chloroquine results in increased activity of RELA protein]
Chloroquine inhibits the reaction [[Diethylnitrosamine co-treated with N-nitrosomorpholine] results in increased expression of RELA protein]
Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased activity of and affects the localization of RELA protein]; Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased activity of RELA protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased activity of and affects the localization of RELA protein]]
Chloroquine results in decreased expression of RELA protein
CTD PMID:15139008 PMID:24990399 PMID:26116531 PMID:28134560 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rheb Ras homolog, mTORC1 binding multiple interactions EXP Chloroquine inhibits the reaction [EGF protein results in increased expression of RHEB protein] CTD PMID:22689575 NCBI chr 4:6,827,429...6,873,384
Ensembl chr 4:6,827,429...6,873,383
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation
multiple interactions
increases expression
ISO
EXP
Chloroquine results in decreased phosphorylation of RPS6KB1 protein
Chloroquine inhibits the reaction [EGF protein results in increased phosphorylation of RPS6KB1 protein]
Chloroquine results in increased expression of RPS6KB1 protein modified form
CTD PMID:22689575 PMID:25884947 PMID:31310755 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO Chloroquine inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased expression of RUNX2 mRNA] CTD PMID:23111315 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Scarb1 scavenger receptor class B, member 1 decreases expression
multiple interactions
EXP
ISO
Chloroquine results in decreased expression of SCARB1 mRNA
[Chloroquine co-treated with Lovastatin] inhibits the reaction [SCARB1 protein results in increased abundance of Progesterone]
CTD PMID:19393257 PMID:20404351 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
JBrowse link
G Sccpdh saccharopine dehydrogenase (putative) decreases expression EXP Chloroquine results in decreased expression of SCCPDH mRNA CTD PMID:19393257 NCBI chr13:97,941,720...97,963,474
Ensembl chr13:97,941,757...97,963,824
Ensembl chr13:97,941,757...97,963,824
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression EXP Chloroquine results in decreased expression of SCD1 mRNA CTD PMID:19393257 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Senp6 SUMO specific peptidase 6 multiple interactions ISO [Lipopolysaccharides co-treated with Chloroquine] results in increased expression of SENP6 protein CTD PMID:26807181 NCBI chr 8:87,486,050...87,568,088
Ensembl chr 8:87,486,427...87,563,652
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO Chloroquine inhibits the reaction [Poly I-C results in increased expression of SERPINE1 mRNA]; Chloroquine inhibits the reaction [Poly I-C results in increased expression of SERPINE1 protein] CTD PMID:30341573 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Slc12a1 solute carrier family 12 member 1 decreases expression ISO Chloroquine results in decreased expression of SLC12A1 protein CTD PMID:22791344 NCBI chr 3:117,421,531...117,498,372
Ensembl chr 3:117,421,604...117,498,367
JBrowse link
G Slc14a2 solute carrier family 14 member 2 multiple interactions ISO Chloroquine inhibits the reaction [AVP protein affects the localization of SLC14A2 protein] CTD PMID:22791344 NCBI chr18:74,508,070...74,941,389
Ensembl chr18:74,546,220...74,688,551
Ensembl chr18:74,546,220...74,688,551
JBrowse link
G Slc19a3 solute carrier family 19 member 3 multiple interactions ISO Chloroquine inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Chloroquine inhibits the reaction [SLC19A3 protein results in increased uptake of Thiamine] CTD PMID:26528626 NCBI chr 9:88,762,775...88,828,553
Ensembl chr 9:88,764,073...88,816,898
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Chloroquine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:27504015 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Chloroquine inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:27504015 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc2a4 solute carrier family 2 member 4 affects localization
multiple interactions
EXP Chloroquine affects the localization of SLC2A4 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Chloroquine affects the localization of SLC2A4 protein] which results in increased uptake of Glucose]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Chloroquine affects the localization of SLC2A4 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Chloroquine affects the localization of SLC2A4 protein]; [[Chloroquine results in increased abundance of Calcium] which affects the localization of SLC2A4 protein] which results in increased uptake of Glucose; [Chloroquine affects the localization of SLC2A4 protein] which results in increased uptake of Glucose; [Chloroquine results in increased abundance of Calcium] which affects the localization of SLC2A4 protein; gallein inhibits the reaction [Chloroquine affects the localization of SLC2A4 protein]
CTD PMID:27160165 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions ISO Chloroquine inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate] CTD PMID:27504015 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions EXP Chloroquine inhibits the reaction [Dibutyl Phthalate results in increased expression of SNAI1 mRNA] CTD PMID:30053495 NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
decreases expression
ISO Quercetin inhibits the reaction [Chloroquine results in decreased expression of SOD1 mRNA] CTD PMID:23607047 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sort1 sortilin 1 decreases expression
multiple interactions
ISO Chloroquine results in decreased expression of SORT1 protein
Chloroquine affects the reaction [SORT1 protein affects the reaction [LDLR protein affects the abundance of Cholesterol]]
CTD PMID:25805502 PMID:30950489 NCBI chr 2:211,078,092...211,156,312
Ensembl chr 2:211,078,334...211,156,312
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression
ISO
EXP
Chloroquine inhibits the reaction [[Simvastatin co-treated with Metformin] results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [[THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [ANGPTL8 protein results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Arsenic Trioxide results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Artesunate results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Cisplatin results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [cryptotanshinone results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [dactolisib results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Doxorubicin results in increased degradation of SQSTM1 protein]; Chloroquine inhibits the reaction [formosanin C results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [fosbretabulin results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Resveratrol results in increased degradation of SQSTM1 protein]; Chloroquine inhibits the reaction [Sorafenib results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [YM 155 results in decreased expression of SQSTM1 protein]; Chloroquine promotes the reaction [alpha-Chlorohydrin results in increased expression of SQSTM1 protein]; Chloroquine promotes the reaction [Arsenic Trioxide results in increased expression of SQSTM1 protein]; Chloroquine promotes the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SQSTM1 protein]; ERGIC3 protein promotes the reaction [Chloroquine results in increased expression of SQSTM1 protein]
Chloroquine inhibits the reaction [cadmium acetate results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Cadmium results in decreased expression of SQSTM1 protein]; Chloroquine promotes the reaction [Glucose results in increased expression of SQSTM1 protein]; Chloroquine promotes the reaction [manganese chloride results in increased expression of SQSTM1 protein]; Chloroquine promotes the reaction [Resveratrol promotes the reaction [Glucose results in increased expression of SQSTM1 protein]]
Chloroquine inhibits the reaction [sunitinib results in decreased expression of SQSTM1 protein]
CTD PMID:21858812 PMID:22927544 PMID:23651616 PMID:24262987 PMID:24751611 PMID:25412314 PMID:25884947 PMID:25943029 PMID:27180204 PMID:27588471 PMID:27658547 PMID:28275691 PMID:28600121 PMID:28713934 PMID:28906492 PMID:29222055 PMID:29248574 PMID:29870746 PMID:30208301 PMID:30237538 PMID:30280407 PMID:30338810 PMID:30550853 PMID:30551460 PMID:31586597 PMID:31837377 PMID:32186374 PMID:32693121 PMID:32702505 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Ssb small RNA binding exonuclease protection factor La multiple interactions ISO Chloroquine inhibits the reaction [SSB protein results in increased expression of CXCL8 mRNA]; Chloroquine inhibits the reaction [SSB protein results in increased secretion of CXCL8 protein] CTD PMID:25915936 NCBI chr 3:56,092,425...56,102,008
Ensembl chr 3:56,092,501...56,102,001
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression EXP Chloroquine results in decreased expression of STAR mRNA CTD PMID:19393257 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Stc2 stanniocalcin 2 decreases expression EXP Chloroquine results in decreased expression of STC2 mRNA CTD PMID:19393257 NCBI chr10:16,542,909...16,552,675
Ensembl chr10:16,542,882...16,553,295
JBrowse link
G Strap serine/threonine kinase receptor associated protein decreases expression EXP Chloroquine results in decreased expression of STRAP mRNA CTD PMID:19393257 NCBI chr 4:171,730,629...171,744,877
Ensembl chr 4:171,730,635...171,745,377
JBrowse link
G Syp synaptophysin multiple interactions EXP Chloroquine inhibits the reaction [Nanotubes, Carbon results in decreased expression of SYP] CTD PMID:26327526 NCBI chr  X:15,694,699...15,709,244
Ensembl chr  X:15,695,566...15,707,436
JBrowse link
G Tardbp TAR DNA binding protein increases expression
multiple interactions
ISO Chloroquine results in increased expression of TARDBP protein
Chloroquine promotes the reaction [VCP protein mutant form results in increased expression of TARDBP protein]
CTD PMID:25884947 NCBI chr 5:165,432,089...165,442,232
Ensembl chr 5:165,432,095...165,442,048
JBrowse link
G Tgoln2 trans-golgi network protein 2 affects localization ISO Chloroquine affects the localization of TGOLN2 protein CTD PMID:29940786 NCBI chr 4:100,475,415...100,483,229
Ensembl chr 4:100,475,416...100,483,168
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Chloroquine inhibits the reaction [[THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein] CTD PMID:24262987 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Ticam2 toll-like receptor adaptor molecule 2 multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TICAM2 mRNA] CTD PMID:22341560 NCBI chr18:40,555,106...40,572,569
Ensembl chr18:40,555,106...40,572,241
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions
decreases expression
ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TIMP1 protein]
Chloroquine results in decreased expression of TIMP1 mRNA
Chloroquine inhibits the reaction [Artesunate results in increased expression of TIMP1 mRNA]
CTD PMID:22341560 PMID:30551460 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TIMP2 protein] CTD PMID:22341560 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
JBrowse link
G Tlr3 toll-like receptor 3 multiple interactions ISO Chloroquine inhibits the reaction [Poly I-C results in increased activity of TLR3 protein] CTD PMID:21398612 NCBI chr16:50,016,466...50,031,011
Ensembl chr16:50,016,857...50,031,214
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Chloroquine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of TLR4 protein] CTD PMID:22341560 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tlr7 toll-like receptor 7 decreases activity ISO Chloroquine results in decreased activity of TLR7 protein CTD PMID:27385120 NCBI chr  X:28,486,836...28,513,004
Ensembl chr  X:28,486,869...28,512,957
JBrowse link
G Tlr8 toll-like receptor 8 decreases activity ISO Chloroquine results in decreased activity of TLR8 protein CTD PMID:27385120 NCBI chr  X:28,539,158...28,562,803
Ensembl chr  X:28,539,158...28,562,803
JBrowse link
G Tlr9 toll-like receptor 9 decreases activity
decreases expression
multiple interactions
increases expression
ISO
EXP
Chloroquine results in decreased activity of TLR9 protein
Chloroquine results in decreased expression of TLR9 protein
Chloroquine inhibits the reaction [[Diethylnitrosamine co-treated with N-nitrosomorpholine] results in increased expression of TLR9 protein]
Chloroquine results in increased expression of TLR9 mRNA
Chloroquine inhibits the reaction [CpG ODN 2006 results in increased activity of TLR9 protein]; Chloroquine inhibits the reaction [CpG ODN 2395 results in increased activity of TLR9 protein]; Chloroquine inhibits the reaction [Oxygen deficiency results in increased expression of TLR9 mRNA]; Oxygen deficiency inhibits the reaction [Chloroquine results in increased expression of TLR9 mRNA]; TLR9 protein promotes the reaction [Oxygen deficiency promotes the reaction [Chloroquine results in increased expression of MMP13 mRNA]]
CTD PMID:21398612 PMID:22595112 PMID:24273604 PMID:24990399 NCBI chr 8:114,916,122...114,920,171
Ensembl chr 8:114,916,122...114,920,171
JBrowse link
G Tm7sf2 transmembrane 7 superfamily member 2 decreases expression EXP Chloroquine results in decreased expression of TM7SF2 mRNA CTD PMID:19393257 NCBI chr 1:221,426,017...221,430,340
Ensembl chr 1:221,425,987...221,431,713
JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
decreases secretion
increases expression
ISO
EXP
Chloroquine results in decreased expression of TNF protein
Chloroquine inhibits the reaction [3,4-dihydroxyphenylethanol inhibits the reaction [Hydrogen Peroxide results in increased secretion of TNF protein]]
[Chloroquine co-treated with TNF protein] results in increased expression of MAP1LC3B protein alternative form; Chloroquine inhibits the reaction [alpinetin inhibits the reaction [TNF protein results in increased cleavage of CASP3 protein]]; Chloroquine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]]; Chloroquine promotes the reaction [[TNF protein co-treated with Resveratrol] results in increased expression of MAP1LC3B protein alternative form]
Chloroquine results in decreased secretion of TNF protein
Chloroquine results in increased expression of TNF
Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased secretion of TNF protein]; Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF mRNA]; Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; Chloroquine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TNF protein]]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TNF mRNA]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TNF protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF mRNA]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]]
CTD PMID:8244452 PMID:9002011 PMID:9799232 PMID:10638776 PMID:15139008 PMID:22341560 PMID:24145604 PMID:26498332 PMID:28134560 PMID:31332898 PMID:31676321 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO Chloroquine results in increased expression of TNFRSF10A protein CTD PMID:27692344 NCBI chr15:51,433,853...51,464,215 JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNFRSF1A protein] CTD PMID:22341560 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNFRSF1B protein] CTD PMID:22341560 NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299
JBrowse link
G Tomm20 translocase of outer mitochondrial membrane 20 multiple interactions ISO Chloroquine promotes the reaction [Triiodothyronine results in increased expression of TOMM20 protein] CTD PMID:30209975 NCBI chr19:59,863,421...59,873,411
Ensembl chr19:59,863,421...59,873,411
JBrowse link
G Tp53 tumor protein p53 increases activity
multiple interactions
ISO Chloroquine results in increased activity of TP53; Chloroquine results in increased activity of TP53 protein
Chloroquine inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]
TRP53 mutant form inhibits the reaction [Chloroquine results in increased activity of CASP3 protein]
CTD PMID:11589424 PMID:12082016 PMID:18089834 PMID:22927544 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression
multiple interactions
ISO Chloroquine results in increased expression of TRIB3 protein
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; [Bortezomib co-treated with Chloroquine] results in increased expression of TRIB3 protein; betulinic acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; Doxorubicin promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of TRIB3 protein]; Doxorubicin promotes the reaction [Chloroquine results in increased expression of TRIB3 protein]; Nitroprusside promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; Nitroprusside promotes the reaction [Chloroquine results in increased expression of TRIB3 protein]
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of TRIB3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased expression of TRIB3 protein]; [Bortezomib co-treated with Chloroquine] results in increased expression of TRIB3 protein; betulinic acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; Doxorubicin promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of TRIB3 protein]; Doxorubicin promotes the reaction [Chloroquine results in increased expression of TRIB3 protein]; Nitroprusside promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; Nitroprusside promotes the reaction [Chloroquine results in increased expression of TRIB3 protein]
CTD PMID:30482226 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
JBrowse link
G Trim63 tripartite motif containing 63 affects expression EXP Chloroquine affects the expression of TRIM63 mRNA CTD PMID:19296457 NCBI chr 5:152,533,362...152,547,138
Ensembl chr 5:152,533,349...152,547,179
JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 multiple interactions EXP Chloroquine inhibits the reaction [Oxygen deficiency results in increased expression of TRPC1 mRNA]; Chloroquine inhibits the reaction [Oxygen deficiency results in increased expression of TRPC1 protein] CTD PMID:32956540 NCBI chr 8:103,503,982...103,554,905
Ensembl chr 8:103,503,985...103,554,468
JBrowse link
G Ubc ubiquitin C increases expression EXP Chloroquine results in increased expression of UBC mRNA CTD PMID:19296457 NCBI chr12:36,638,457...36,642,734
Ensembl chr12:36,638,457...36,642,734
JBrowse link
G Usp2 ubiquitin specific peptidase 2 multiple interactions
increases expression
ISO Chloroquine promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of USP2 mRNA]; lipopolysaccharide, E coli O55-B5 promotes the reaction [Chloroquine results in increased expression of USP2 mRNA] CTD PMID:28134560 NCBI chr 8:48,403,985...48,432,525
Ensembl chr 8:48,406,260...48,430,885
JBrowse link
G Usp25 ubiquitin specific peptidase 25 increases expression
multiple interactions
ISO Chloroquine results in increased expression of USP25 mRNA; Chloroquine results in increased expression of USP25 protein
[Chloroquine co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of USP25 mRNA; [lipopolysaccharide, E coli O55-B5 co-treated with Chloroquine] results in increased expression of USP25 protein; Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of USP25 mRNA]; lipopolysaccharide, E coli O55-B5 inhibits the reaction [Chloroquine results in increased expression of USP25 mRNA]; USP25 protein affects the reaction [[Chloroquine co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of USP25 mRNA]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of IRF3 protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased activity of and affects the localization of RELA protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNB1 mRNA]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNB1 protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF mRNA]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK1 protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK3 protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK8 protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL6 protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]]
CTD PMID:28134560 NCBI chr11:15,436,080...15,558,646
Ensembl chr11:15,436,269...15,558,646
Ensembl chr11:15,436,269...15,558,646
JBrowse link
G Usp28 ubiquitin specific peptidase 28 multiple interactions
increases expression
ISO Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of USP28 mRNA]; lipopolysaccharide, E coli O55-B5 inhibits the reaction [Chloroquine results in increased expression of USP28 mRNA] CTD PMID:28134560 NCBI chr 8:53,295,188...53,355,572
Ensembl chr 8:53,295,222...53,355,572
JBrowse link
G Usp7 ubiquitin specific peptidase 7 increases expression
multiple interactions
ISO Chloroquine results in increased expression of USP7 mRNA
Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of USP7 mRNA]; lipopolysaccharide, E coli O55-B5 inhibits the reaction [Chloroquine results in increased expression of USP7 mRNA]
CTD PMID:28134560 NCBI chr10:6,930,462...7,019,910
Ensembl chr10:6,975,244...7,018,930
JBrowse link
G Vcp valosin-containing protein multiple interactions ISO Chloroquine inhibits the reaction [VCP protein mutant form results in decreased expression of MAP1LC3B protein]; Chloroquine inhibits the reaction [VCP protein mutant form results in increased expression of OPTN protein]
Chloroquine promotes the reaction [VCP protein mutant form results in increased expression of TARDBP protein]
CTD PMID:25884947 NCBI chr 5:58,426,548...58,445,953
Ensembl chr 5:58,426,549...58,445,953
JBrowse link
G Vsnl1 visinin-like 1 decreases expression EXP Chloroquine results in decreased expression of VSNL1 mRNA CTD PMID:19393257 NCBI chr 6:37,001,360...37,121,969
Ensembl chr 6:37,001,356...37,122,023
JBrowse link
G Xcl1 X-C motif chemokine ligand 1 multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of XCL1 protein] CTD PMID:22341560 NCBI chr13:83,199,402...83,202,845
Ensembl chr13:83,199,264...83,202,864
JBrowse link
hydroxychloroquine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alpl alkaline phosphatase, biomineralization associated affects expression
multiple interactions
ISO Hydroxychloroquine affects the expression of ALPL mRNA
Hydroxychloroquine affects the reaction [Simvastatin affects the expression of ALPL mRNA]
CTD PMID:28975700 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases activity
ISO bafilomycin A1 inhibits the reaction [Hydroxychloroquine results in increased activity of BAX protein] CTD PMID:12813466 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
ISO benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Hydroxychloroquine results in increased cleavage of CASP3 protein]; FAS protein affects the reaction [Hydroxychloroquine results in increased activity of CASP3 protein] CTD PMID:12813466 PMID:16734620 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Hydroxychloroquine results in increased expression of CCL2 mRNA CTD PMID:15139008 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cd14 CD14 molecule multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD14 mRNA CTD PMID:28863153 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cd19 CD19 molecule multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD19 mRNA CTD PMID:28863153 NCBI chr 1:197,815,422...197,822,123
Ensembl chr 1:197,815,413...197,821,936
JBrowse link
G Cd27 CD27 molecule multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD27 mRNA CTD PMID:28863153 NCBI chr 4:157,744,881...157,751,609
Ensembl chr 4:157,744,882...157,750,088
JBrowse link
G Cd38 CD38 molecule multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD38 mRNA CTD PMID:28863153 NCBI chr14:71,714,768...71,754,990
Ensembl chr14:71,715,269...71,754,672
JBrowse link
G Cd3d CD3d molecule multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD3D mRNA CTD PMID:28863153 NCBI chr 8:49,282,502...49,287,095
Ensembl chr 8:49,282,460...49,287,110
JBrowse link
G Cd40lg CD40 ligand decreases expression ISO Hydroxychloroquine results in decreased expression of CD40LG protein CTD PMID:28793932 NCBI chr  X:159,703,703...159,714,886
Ensembl chr  X:159,703,578...159,716,562
JBrowse link
G Cd74 CD74 molecule multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD74 mRNA CTD PMID:28863153 NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression ISO Hydroxychloroquine results in decreased expression of CFLAR mRNA; Hydroxychloroquine results in decreased expression of CFLAR protein CTD PMID:16734620 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Cldn1 claudin 1 increases expression ISO Hydroxychloroquine results in increased expression of CLDN1 mRNA CTD PMID:25752684 NCBI chr11:77,815,216...77,830,373
Ensembl chr11:77,815,181...77,830,416
JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CTLA4 mRNA CTD PMID:28863153 NCBI chr 9:67,699,397...67,706,068
Ensembl chr 9:67,699,379...67,706,065
JBrowse link
G Ctsb cathepsin B affects localization
multiple interactions
ISO Hydroxychloroquine affects the localization of CTSB protein
bafilomycin A1 inhibits the reaction [Hydroxychloroquine affects the localization of CTSB protein]
CTD PMID:12813466 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CXCL1 mRNA CTD PMID:28863153 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression ISO Hydroxychloroquine results in increased expression of CXCL10 mRNA CTD PMID:25321315 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CXCL1 mRNA CTD PMID:28863153 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
decreases activity
ISO Hydroxychloroquine inhibits the reaction [CYP2D6 protein results in increased metabolism of Metoprolol]
Hydroxychloroquine results in decreased activity of CYP2D6 protein
CTD PMID:10848718 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Ddx58 DEXD/H-box helicase 58 increases expression ISO Hydroxychloroquine results in increased expression of DDX58 mRNA CTD PMID:25321315 NCBI chr 5:56,486,584...56,536,898
Ensembl chr 5:56,500,734...56,536,772
JBrowse link
G Dhcr7 7-dehydrocholesterol reductase affects expression
multiple interactions
ISO Hydroxychloroquine affects the expression of DHCR7 mRNA
Hydroxychloroquine affects the reaction [Simvastatin affects the expression of DHCR7 mRNA]
CTD PMID:28975700 NCBI chr 1:217,018,916...217,034,890
Ensembl chr 1:217,018,916...217,034,904
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression ISO Hydroxychloroquine results in increased expression of ERN1 protein CTD PMID:25321315 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO FAS protein affects the reaction [Hydroxychloroquine results in increased activity of CASP3 protein] CTD PMID:16734620 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
affects expression
ISO Simvastatin affects the reaction [Hydroxychloroquine affects the expression of HMGCR mRNA] CTD PMID:28975700 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Ifih1 interferon induced with helicase C domain 1 increases expression ISO Hydroxychloroquine results in increased expression of IFIH1 mRNA CTD PMID:25321315 NCBI chr 3:48,557,696...48,604,097
Ensembl chr 3:48,557,696...48,604,097
JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 increases expression ISO Hydroxychloroquine results in increased expression of IFIT3 mRNA CTD PMID:25321315 NCBI chr 1:252,906,234...252,911,377
Ensembl chr 1:252,906,234...252,911,382
JBrowse link
G Ifnb1 interferon beta 1 increases expression ISO Hydroxychloroquine results in increased expression of IFNB1 mRNA CTD PMID:25321315 NCBI chr 5:106,865,192...106,865,746
Ensembl chr 5:106,865,192...106,865,746
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Hydroxychloroquine co-treated with Imiquimod] results in increased secretion of IL10 protein CTD PMID:31082466 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il10ra interleukin 10 receptor subunit alpha multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of IL10RA mRNA CTD PMID:28863153 NCBI chr 8:49,558,062...49,573,891
Ensembl chr 8:49,560,035...49,573,742
JBrowse link
G Il12b interleukin 12B increases expression ISO Hydroxychloroquine results in increased expression of IL12B mRNA CTD PMID:25321315 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Hydroxychloroquine inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]
Hydroxychloroquine inhibits the reaction [Fluorouracil results in increased secretion of IL1B protein]
CTD PMID:16393772 PMID:32314717 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il23a interleukin 23 subunit alpha increases expression ISO Hydroxychloroquine results in increased expression of IL23A mRNA CTD PMID:25321315 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO [Hydroxychloroquine co-treated with Imiquimod] results in increased secretion of IL6 protein; [Hydroxychloroquine co-treated with ODN2006] results in increased secretion of IL6 protein; Hydroxychloroquine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
Hydroxychloroquine results in increased expression of IL6 mRNA
CTD PMID:9002011 PMID:25321315 PMID:31082466 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Irf3 interferon regulatory factor 3 increases expression
multiple interactions
increases phosphorylation
ISO Hydroxychloroquine results in increased expression of IRF3 mRNA
phenyl-N-tert-butylnitrone inhibits the reaction [Hydroxychloroquine results in increased phosphorylation of IRF3 protein]
CTD PMID:25321315 NCBI chr 1:100,992,244...100,997,202
Ensembl chr 1:100,992,405...100,997,198
JBrowse link
G Irf4 interferon regulatory factor 4 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of IRF4 mRNA CTD PMID:28863153 NCBI chr17:34,886,746...34,905,191
Ensembl chr17:34,886,739...34,905,117
JBrowse link
G Irf7 interferon regulatory factor 7 increases expression ISO Hydroxychloroquine results in increased expression of IRF7 mRNA CTD PMID:25321315 NCBI chr 1:214,249,388...214,252,909
Ensembl chr 1:214,248,837...214,252,456
JBrowse link
G Itk IL2-inducible T-cell kinase multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of ITK mRNA CTD PMID:28863153 NCBI chr10:31,431,820...31,493,413
Ensembl chr10:31,431,809...31,493,419
JBrowse link
G Jchain joining chain of multimeric IgA and IgM multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of JCHAIN mRNA CTD PMID:28863153 NCBI chr14:21,176,841...21,183,731
Ensembl chr14:21,177,237...21,183,542
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation
multiple interactions
ISO Hydroxychloroquine results in increased phosphorylation of JUN protein
phenyl-N-tert-butylnitrone inhibits the reaction [Hydroxychloroquine results in increased phosphorylation of JUN protein]
CTD PMID:25321315 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of LCK mRNA CTD PMID:28863153 NCBI chr 5:147,750,976...147,779,627
Ensembl chr 5:147,750,973...147,761,983
JBrowse link
G Mavs mitochondrial antiviral signaling protein increases expression
multiple interactions
ISO Hydroxychloroquine results in increased expression of MAVS mRNA; Hydroxychloroquine results in increased expression of MAVS protein
phenyl-N-tert-butylnitrone inhibits the reaction [Hydroxychloroquine results in increased expression of MAVS protein]
CTD PMID:25321315 NCBI chr 3:123,776,147...123,790,572
Ensembl chr 3:123,776,181...123,790,567
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of MMP1 mRNA CTD PMID:28863153 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Ms4a1 membrane spanning 4-domains A1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of MS4A1 mRNA CTD PMID:28863153 NCBI chr 1:227,429,241...227,441,492
Ensembl chr 1:227,429,596...227,441,442
JBrowse link
G Mvp major vault protein increases expression ISO Hydroxychloroquine results in increased expression of MVP mRNA CTD PMID:25321315 NCBI chr 1:198,420,813...198,448,612
Ensembl chr 1:198,420,806...198,450,047
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 affects expression ISO Hydroxychloroquine affects the expression of NFATC1 protein CTD PMID:28793932 NCBI chr18:77,203,517...77,322,690
Ensembl chr18:77,203,525...77,322,690
JBrowse link
G Nfatc2 nuclear factor of activated T-cells 2 affects localization ISO Hydroxychloroquine affects the localization of NFATC2 protein CTD PMID:28793932 NCBI chr 3:165,241,750...165,374,644
Ensembl chr 3:165,245,238...165,360,292
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases degradation
ISO phenyl-N-tert-butylnitrone inhibits the reaction [Hydroxychloroquine results in increased degradation of NFKBIA protein] CTD PMID:25321315 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Hydroxychloroquine inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide] CTD PMID:16393772 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Ocln occludin increases expression ISO Hydroxychloroquine results in increased expression of OCLN mRNA CTD PMID:25752684 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 multiple interactions ISO Hydroxychloroquine binds to and results in decreased activity of PPT1 protein CTD PMID:30442709 NCBI chr 5:140,538,260...140,558,163
Ensembl chr 5:140,538,260...140,558,162
JBrowse link
G Prdm1 PR/SET domain 1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of PRDM1 mRNA CTD PMID:28863153 NCBI chr20:49,464,921...49,556,623
Ensembl chr20:49,464,919...49,556,518
JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of RASGRP1 mRNA CTD PMID:28863153 NCBI chr 3:108,984,029...109,044,420
Ensembl chr 3:108,984,029...109,044,420
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression ISO Hydroxychloroquine results in increased expression of RELA protein CTD PMID:25321315 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 increases expression ISO Hydroxychloroquine results in increased expression of RSAD2 mRNA CTD PMID:25321315 NCBI chr 6:45,655,947...45,669,083
Ensembl chr 6:45,655,954...45,669,148
JBrowse link
G Sdc1 syndecan 1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of SDC1 mRNA CTD PMID:28863153 NCBI chr 6:33,885,576...33,908,038
Ensembl chr 6:33,885,495...33,908,016
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO Hydroxychloroquine inhibits the reaction [Poly I-C results in increased expression of SERPINE1 mRNA]; Hydroxychloroquine inhibits the reaction [Poly I-C results in increased expression of SERPINE1 protein] CTD PMID:30341573 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Slamf7 SLAM family member 7 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of SLAMF7 mRNA CTD PMID:28863153 NCBI chr13:90,056,726...90,075,159
Ensembl chr13:90,058,127...90,075,144
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression
ISO Hydroxychloroquine inhibits the reaction [Metformin inhibits the reaction [Galactose results in increased expression of SQSTM1 protein]]
Hydroxychloroquine results in increased expression of SQSTM1 protein
[Dronabinol co-treated with Hydroxychloroquine] results in increased expression of SQSTM1 protein; [HU 211 co-treated with Hydroxychloroquine] results in increased expression of SQSTM1 protein
CTD PMID:29426000 PMID:32773031 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Tlr7 toll-like receptor 7 decreases expression ISO Hydroxychloroquine results in decreased expression of TLR7 protein CTD PMID:22513098 NCBI chr  X:28,486,836...28,513,004
Ensembl chr  X:28,486,869...28,512,957
JBrowse link
G Tlr9 toll-like receptor 9 decreases expression
multiple interactions
ISO Hydroxychloroquine results in decreased expression of TLR9 protein
Hydroxychloroquine inhibits the reaction [Fluorouracil results in increased secretion of TLR9 protein]
CTD PMID:22513098 PMID:32314717 NCBI chr 8:114,916,122...114,920,171
Ensembl chr 8:114,916,122...114,920,171
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of TNF mRNA; Hydroxychloroquine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Hydroxychloroquine results in increased expression of TNF mRNA
CTD PMID:9002011 PMID:25321315 PMID:28863153 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf17 TNF receptor superfamily member 17 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of TNFRSF17 mRNA CTD PMID:28863153 NCBI chr10:4,252,097...4,258,335
Ensembl chr10:4,251,941...4,257,868
JBrowse link
G Traf3 Tnf receptor-associated factor 3 increases expression ISO Hydroxychloroquine results in increased expression of TRAF3 mRNA CTD PMID:25321315 NCBI chr 6:135,610,698...135,720,247
Ensembl chr 6:135,610,743...135,718,564
JBrowse link
G Traf6 TNF receptor associated factor 6 increases expression ISO Hydroxychloroquine results in increased expression of TRAF6 mRNA CTD PMID:25321315 NCBI chr 3:91,252,829...91,271,607
Ensembl chr 3:91,252,829...91,271,607
JBrowse link
G Trim21 tripartite motif-containing 21 increases expression ISO Hydroxychloroquine results in increased expression of TRIM21 mRNA CTD PMID:25321315 NCBI chr 1:167,686,148...167,708,735
Ensembl chr 1:167,686,173...167,708,714
JBrowse link
G Txnip thioredoxin interacting protein multiple interactions ISO Hydroxychloroquine inhibits the reaction [Metformin inhibits the reaction [Galactose results in increased expression of TXNIP protein]] CTD PMID:29426000 NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974
JBrowse link
G Uxt ubiquitously-expressed, prefoldin-like chaperone increases expression ISO Hydroxychloroquine results in increased expression of UXT mRNA CTD PMID:25321315 NCBI chr  X:1,275,402...1,287,781
Ensembl chr  X:1,275,612...1,287,512
JBrowse link
G Vcl vinculin multiple interactions ISO Hydroxychloroquine inhibits the reaction [[Dexamethasone co-treated with beta-glycerophosphoric acid] results in increased expression of VCL protein] CTD PMID:28975700 NCBI chr15:3,455,211...3,544,738
Ensembl chr15:3,455,211...3,544,702
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of XBP1 mRNA CTD PMID:28863153 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19720
      biological role 19720
        inhibitor 18301
          autophagy inhibitor 669
            chloroquine 276
              (R)-chloroquine 0
              (S)-chloroquine 0
              chloroquine sulfate 0
              hydroxychloroquine 69
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    main group molecular entity 19662
                      s-block molecular entity 19429
                        hydrogen molecular entity 19423
                          hydrides 18758
                            inorganic hydride 17453
                              pnictogen hydride 17428
                                nitrogen hydride 17272
                                  azane 17003
                                    ammonia 17002
                                      organic amino compound 17001
                                        aromatic amine 13670
                                          aminoquinoline 1694
                                            chloroquine 276
                                              (R)-chloroquine 0
                                              (S)-chloroquine 0
                                              chloroquine sulfate 0
                                              hydroxychloroquine 69
paths to the root