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G |
PLCG1 |
phospholipase C gamma 1 |
decreases activity multiple interactions |
EXP |
1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein dipalmitoylphosphatidic acid inhibits the reaction [1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein] |
CTD |
PMID:2001791 |
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NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714
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G |
KCNJ3 |
potassium inwardly rectifying channel subfamily J member 3 |
multiple interactions |
EXP |
Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] |
CTD |
PMID:10666054 |
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NCBI chr36:1,354,686...1,496,397
Ensembl chr36:1,354,678...1,493,766
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G |
KCNJ6 |
potassium inwardly rectifying channel subfamily J member 6 |
multiple interactions |
EXP |
Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] |
CTD |
PMID:10666054 |
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NCBI chr31:32,752,585...33,010,999
Ensembl chr31:32,755,899...32,934,478
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G |
MAPK14 |
mitogen-activated protein kinase 14 |
multiple interactions |
EXP |
Acetylcholine results in increased phosphorylation of and results in increased activity of MAPK14 protein |
CTD |
PMID:9688607 |
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NCBI chr12:5,145,647...5,221,558
Ensembl chr12:5,146,037...5,220,603
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G |
HSP70 |
heat shock protein 70 |
increases expression multiple interactions |
EXP |
arsenite results in increased expression of HSP70 mRNA HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]] |
CTD |
PMID:32899721 |
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NCBI chr12:1,285,282...1,287,670
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G |
IL1B |
interleukin 1 beta |
multiple interactions |
EXP |
arsenite affects the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]] |
CTD |
PMID:32899721 |
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NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458
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G |
IL6 |
interleukin 6 |
multiple interactions |
EXP |
arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]] |
CTD |
PMID:32899721 |
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NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519
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G |
RELA |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP |
arsenite inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]] |
CTD |
PMID:32899721 |
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NCBI chr18:51,550,003...51,558,861
Ensembl chr18:51,550,040...51,558,875
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G |
TNF |
tumor necrosis factor |
multiple interactions |
EXP |
arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]] |
CTD |
PMID:32899721 |
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NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425
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G |
BCHE |
butyrylcholinesterase |
increases hydrolysis multiple interactions |
EXP |
BCHE protein results in increased hydrolysis of butyrylcholine Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine] |
CTD |
PMID:4631366 PMID:4985882 |
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NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583
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G |
BCHE |
butyrylcholinesterase |
increases hydrolysis |
EXP |
BCHE protein results in increased hydrolysis of Butyrylthiocholine |
CTD |
PMID:22407886 |
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NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583
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G |
CASP3 |
caspase 3 |
multiple interactions increases activity |
EXP |
Diosgenin inhibits the reaction [Calcium Oxalate results in increased activity of CASP3 protein] |
CTD |
PMID:25446497 |
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NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505
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G |
CASP9 |
caspase 9 |
increases activity multiple interactions |
EXP |
Calcium Oxalate results in increased activity of CASP9 protein Diosgenin inhibits the reaction [Calcium Oxalate results in increased activity of CASP9 protein] |
CTD |
PMID:25446497 |
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NCBI chr 2:82,033,759...82,076,710
Ensembl chr 2:82,031,563...82,090,484
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G |
TJP1 |
tight junction protein 1 |
multiple interactions decreases expression |
EXP |
Docetaxel inhibits the reaction [Calcium Oxalate results in decreased expression of TJP1 protein]; Phalloidine inhibits the reaction [Calcium Oxalate results in decreased expression of TJP1 protein] |
CTD |
PMID:34147488 PMID:36349591 |
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NCBI chr 3:38,997,122...39,076,617
Ensembl chr 3:38,997,076...39,241,574
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G |
SCT |
secretin |
increases abundance multiple interactions |
EXP |
SCT protein results in increased abundance of Bicarbonates [Ceruletide co-treated with SCT protein] results in increased abundance of Bicarbonates; Atropine inhibits the reaction [SCT protein results in increased abundance of Bicarbonates] |
CTD |
PMID:3562434 |
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G |
PTGS1 |
prostaglandin-endoperoxide synthase 1 |
decreases activity |
EXP |
Dipyrone results in decreased activity of PTGS1 protein alternative form |
CTD |
PMID:12242329 |
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NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
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G |
NCF1 |
neutrophil cytosolic factor 1 |
decreases expression |
EXP |
pitavastatin results in decreased expression of NCF1 mRNA |
CTD |
PMID:15502390 |
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NCBI chr 6:5,702,222...5,719,515
Ensembl chr 6:5,605,694...5,719,458
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G |
NOS3 |
nitric oxide synthase 3 |
increases activity increases expression |
EXP |
pitavastatin results in increased activity of NOS3 protein pitavastatin results in increased expression of NOS3 mRNA |
CTD |
PMID:15502390 |
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NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277
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G |
NOX4 |
NADPH oxidase 4 |
decreases expression |
EXP |
pitavastatin results in decreased expression of NOX4 mRNA |
CTD |
PMID:15502390 |
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NCBI chr21:10,615,153...10,782,927
Ensembl chr21:10,615,970...10,775,277
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G |
BCHE |
butyrylcholinesterase |
increases hydrolysis multiple interactions |
EXP |
BCHE protein results in increased hydrolysis of Succinylcholine Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine] |
CTD |
PMID:4985882 |
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NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583
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