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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:naphthalenesulfonic acid
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Accession:CHEBI:36336 term browser browse the term
Synonyms:related_synonym: naphthalenesulfonic acids


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8-anilinonaphthalene-1-sulfonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ambp alpha-1-microglobulin/bikunin precursor affects binding ISO 1-anilino-8-naphthalenesulfonate binds to AMBP protein CTD PMID:16461020 NCBI chr 5:78,975,690...78,986,021
Ensembl chr 5:78,975,678...78,985,990
JBrowse link
G Apod apolipoprotein D affects binding ISO 1-anilino-8-naphthalenesulfonate binds to APOD protein CTD PMID:16461020 NCBI chr11:72,705,204...72,726,263
Ensembl chr11:72,705,129...72,726,301
JBrowse link
G C8g complement C8 gamma chain affects binding ISO 1-anilino-8-naphthalenesulfonate binds to C8G protein CTD PMID:16461020 NCBI chr 3:2,724,616...2,727,616
Ensembl chr 3:2,724,616...2,727,616
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 affects binding ISO 1-anilino-8-naphthalenesulfonate binds to GSTA1 protein CTD PMID:14690442 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Lcn1 lipocalin 1 affects binding ISO 1-anilino-8-naphthalenesulfonate binds to LCN1 protein CTD PMID:16461020 NCBI chr 3:4,233,111...4,236,960
Ensembl chr 3:4,233,111...4,236,960
JBrowse link
G Lcn2 lipocalin 2 affects binding ISO 1-anilino-8-naphthalenesulfonate binds to LCN2 protein CTD PMID:16461020 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
G Obp2a odorant binding protein 2A affects binding ISO 1-anilino-8-naphthalenesulfonate binds to OBP2A protein CTD PMID:16461020 NCBI chr 3:2,908,684...2,913,362
Ensembl chr 3:2,910,083...2,913,362
JBrowse link
G Orm1 orosomucoid 1 affects binding ISO 1-anilino-8-naphthalenesulfonate binds to ORM1 protein CTD PMID:16461020 NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820
JBrowse link
G Paep progestagen associated endometrial protein affects binding ISO 1-anilino-8-naphthalenesulfonate binds to PAEP protein CTD PMID:16461020 NCBI chr 3:2,935,396...2,938,883 JBrowse link
G Ptgds prostaglandin D2 synthase affects binding ISO 1-anilino-8-naphthalenesulfonate binds to PTGDS protein CTD PMID:16461020 NCBI chr 3:2,686,125...2,689,059
Ensembl chr 3:2,686,123...2,689,084
JBrowse link
G Ttr transthyretin affects binding
multiple interactions
ISO 1-anilino-8-naphthalenesulfonate binds to TTR protein
3,3'-dichlorobiphenyl metabolite inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]; 3,4-dichlorinated biphenyl metabolite inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]; 4-chlorobiphenyl metabolite inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]; Thyroxine inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]
CTD PMID:23584369 NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177
JBrowse link
Congo Red term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions
affects binding
EXP
ISO
Congo Red inhibits the reaction [APP protein binds to APP protein]
Congo Red binds to APP protein
CTD PMID:17323972, PMID:17406451 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Prnp prion protein decreases expression ISO Congo Red results in decreased expression of PRNP protein alternative form CTD PMID:11994310 NCBI chr 3:124,515,917...124,531,320
Ensembl chr 3:124,515,978...124,531,316
JBrowse link
suramin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calca calcitonin-related polypeptide alpha multiple interactions EXP Suramin inhibits the reaction [Adenosine Triphosphate promotes the reaction [Protons results in increased secretion of CALCA protein]] CTD PMID:12044622 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Casp1 caspase 1 multiple interactions EXP Suramin inhibits the reaction [Glucose results in increased activity of CASP1 protein] CTD PMID:21832250 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Suramin inhibits the reaction [Adenosine Triphosphate results in increased expression of CASP3]; Suramin inhibits the reaction [Clodronic Acid results in increased expression of CASP3] CTD PMID:19448140 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit increases expression ISO Suramin results in increased expression of CHRNA7 protein CTD PMID:23516405 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein] CTD PMID:18612546 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Suramin results in decreased activity of CYP1A2 protein CTD PMID:11124226 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO Suramin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA] CTD PMID:22167199 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO Suramin results in decreased activity of CYP2C19 protein CTD PMID:11124226 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP Suramin inhibits the reaction [sodium arsenite results in increased phosphorylation of EGFR protein] CTD PMID:9710602 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression ISO Suramin results in increased expression of FGF2 CTD PMID:8394679 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgf5 fibroblast growth factor 5 increases expression ISO Suramin results in increased expression of FGF5 CTD PMID:8394679 NCBI chr14:12,974,921...12,996,046
Ensembl chr14:12,974,921...12,995,584
JBrowse link
G Fgf7 fibroblast growth factor 7 affects localization
multiple interactions
ISO Suramin affects the localization of FGF7 protein
Suramin inhibits the reaction [FGF7 protein binds to FGFR2 protein]
CTD PMID:15733146 NCBI chr 3:118,315,859...118,368,464
Ensembl chr 3:118,317,761...118,366,872
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 multiple interactions ISO Suramin inhibits the reaction [FGF7 protein binds to FGFR2 protein] CTD PMID:15733146 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928
JBrowse link
G Fmr1 FMRP translational regulator 1 multiple interactions ISO Suramin inhibits the reaction [Poly I-C results in decreased expression of FMR1 protein] CTD PMID:23516405 NCBI chr  X:154,684,924...154,722,369
Ensembl chr  X:154,684,935...154,722,314
JBrowse link
G Hpgds hematopoietic prostaglandin D synthase decreases activity ISO Suramin results in decreased activity of HPGDS protein CTD PMID:25603235 NCBI chr 4:95,945,356...95,970,666
Ensembl chr 4:95,946,025...95,970,666
JBrowse link
G Il10 interleukin 10 multiple interactions
decreases activity
ISO Suramin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of IL10 protein]
Suramin results in decreased activity of IL10 protein
CTD PMID:15914193 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12b interleukin 12B increases expression ISO Suramin results in increased expression of IL12B protein CTD PMID:15914193 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Suramin inhibits the reaction [Adenosine Triphosphate results in increased expression of IL6 protein]; Suramin inhibits the reaction [Silicon Dioxide analog results in increased expression of IL6 protein]; Suramin inhibits the reaction [Uridine Triphosphate results in increased expression of IL6 protein]
Suramin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
CTD PMID:24793913, PMID:24849676 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Lmna lamin A/C multiple interactions ISO Suramin inhibits the reaction [LMNA protein binds to and results in increased activity of SIRT1 protein] CTD PMID:23217256 NCBI chr 2:187,842,884...187,863,552
Ensembl chr 2:187,842,885...187,863,516
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP
Suramin inhibits the reaction [arsenic acid results in increased activity of MAPK1 protein]; Suramin inhibits the reaction [arsenite results in increased activity of MAPK1 protein]; Suramin inhibits the reaction [Estradiol results in increased phosphorylation of MAPK1 protein]; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK1 protein]
Suramin inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Suramin inhibits the reaction [2,6-di-tert-butyl-4-hydroperoxy-4-methyl-2,5-cyclohexadienone results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Suramin inhibits the reaction [Poly I-C results in decreased phosphorylation of MAPK1 protein]
CTD PMID:8758915, PMID:9710602, PMID:14674888, PMID:15930183, PMID:18612546, PMID:23516405 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP
Suramin inhibits the reaction [arsenic acid results in increased activity of MAPK3 protein]; Suramin inhibits the reaction [arsenite results in increased activity of MAPK3 protein]; Suramin inhibits the reaction [Estradiol results in increased phosphorylation of MAPK3 protein]; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein]
Suramin inhibits the reaction [Poly I-C results in decreased phosphorylation of MAPK3 protein]
Suramin inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:9710602, PMID:14674888, PMID:15930183, PMID:18612546, PMID:23516405 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G P2rx3 purinergic receptor P2X 3 multiple interactions EXP Suramin inhibits the reaction [Cyclophosphamide results in increased expression of P2RX3 protein] CTD PMID:23666265 NCBI chr 3:72,403,992...72,447,801
Ensembl chr 3:72,403,993...72,447,801
JBrowse link
G P2rx7 purinergic receptor P2X 7 multiple interactions ISO Suramin inhibits the reaction [Poly I-C results in decreased expression of P2RX7 protein] CTD PMID:23516405 NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042
JBrowse link
G P2ry2 purinergic receptor P2Y2 decreases activity
multiple interactions
EXP
ISO
Suramin results in decreased activity of P2RY2 protein
Suramin inhibits the reaction [Poly I-C results in decreased expression of P2RY2 protein]
CTD PMID:15654852, PMID:23516405 NCBI chr 1:166,031,228...166,045,423
Ensembl chr 1:166,031,272...166,037,424
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO JTE 013 promotes the reaction [Suramin inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; Suramin inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; Suramin promotes the reaction [JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]] CTD PMID:18612546 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Shc1 SHC adaptor protein 1 multiple interactions
increases expression
EXP
ISO
Suramin inhibits the reaction [sodium arsenite results in increased phosphorylation of SHC1 protein]
Suramin results in increased expression of SHC1 mRNA; Suramin results in increased expression of SHC1 protein
CTD PMID:9710602, PMID:21778425 NCBI chr 2:188,745,503...188,757,066
Ensembl chr 2:188,745,503...188,757,066
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO Suramin inhibits the reaction [LMNA protein binds to and results in increased activity of SIRT1 protein]; Suramin results in decreased activity of [SIRT1 protein results in decreased acetylation of TP53 protein]
[Suramin results in decreased activity of SIRT1 protein] which results in decreased susceptibility to resveratrol
CTD PMID:18482975, PMID:23217256, PMID:24252177 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Tacr1 tachykinin receptor 1 multiple interactions EXP Suramin inhibits the reaction [Cyclophosphamide results in increased expression of TACR1 protein] CTD PMID:23666265 NCBI chr 4:113,247,236...113,416,139
Ensembl chr 4:113,247,795...113,414,504
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Suramin results in increased expression of TNF protein CTD PMID:15914193 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Suramin results in decreased activity of [SIRT1 protein results in decreased acetylation of TP53 protein] CTD PMID:18482975 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Vdr vitamin D receptor multiple interactions ISO Suramin inhibits the reaction [Estradiol results in increased expression of VDR protein] CTD PMID:15930183 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    chemical entity 19787
      group 19698
        inorganic group 19148
          sulfo group 5733
            organosulfonic acid 5733
              arenesulfonic acid 674
                naphthalenesulfonic acid 44
                  2-(acetylamino)naphthalene-1,5-disulfonic acid 0
                  2-naphthalenesulfonic acid [2-[(2-amino-4-oxo-5-thiazolylidene)methyl]phenyl] ester 0
                  3,3'-(biphenyl-4,4'-diyldidiazene-2,1-diyl)bis(4-aminonaphthalene-1-sulfonic acid) + 2
                  4,5-dihydroxy-3-(phenyldiazenyl)naphthalene-2,7-disulfonic acid 0
                  4-[(2,4-dimethylphenyl)diazenyl]-3-hydroxynaphthalene-2,7-disulfonic acid 0
                  4-amino-3-hydroxynaphthalene-1-sulfonic acid 0
                  4-hydroxy-3-[(2-methoxyphenyl)diazenyl]naphthalene-1-sulfonic acid 0
                  5-acetamido-4-hydroxy-3-(phenyldiazenyl)naphthalene-2,7-disulfonic acid 0
                  7-hydroxy-8-[(E)-phenyldiazenyl]naphthalene-1,3-disulfonic acid 0
                  7-hydroxy-8-[(naphthalen-1-yl)diazenyl]naphthalene-1,3-disulfonic acid 0
                  7-hydroxy-8-\{[4-(phenyldiazenyl)phenyl]diazenyl\}naphthalene-1,3-disulfonic acid 0
                  8-Phenylamino-naphthalene-1-sulfonic acid anion 0
                  8-anilinonaphthalene-1-sulfonic acid 11
                  8-oxo-7-[(6-sulfo-2-naphthalenyl)hydrazinylidene]-5-quinolinesulfonic acid 0
                  Evans blue free acid 0
                  Reactive Red 6 hapten + 0
                  Reactive Red 6 hapten copper complex 0
                  Reactive red 120 0
                  Sirius red 4B (acid form) 0
                  Sirius red F3B (acid form) 0
                  aminonaphthalenesulfonic acid + 0
                  benzo scarlet 4BNS free acid 0
                  chromotropic acid 0
                  dibunic acid 0
                  ethyl dibunate 0
                  flavianic acid 0
                  naphthalene-1,3,5-trisulfonic acid + 31
                  naphthalene-1,3,6-trisulfonic acid 0
                  naphthalene-1,5-disulfonic acid 0
                  naphthalene-1,6-disulfonic acid 0
                  naphthalene-1-sulfonic acid 0
                  naphthalene-2,6-disulfonic acid 0
                  naphthalene-2,7-disulfonic acid 0
                  naphthalene-2-sulfonic acid 0
                  suramin 31
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      chalcogen 19362
                        oxygen atom 19323
                          oxygen molecular entity 19323
                            hydroxides 19068
                              oxoacid 18193
                                chalcogen oxoacid 11482
                                  sulfur oxoacid 11085
                                    sulfonic acid 7333
                                      sulfo group 5733
                                        organosulfonic acid 5733
                                          arenesulfonic acid 674
                                            naphthalenesulfonic acid 44
                                              2-(acetylamino)naphthalene-1,5-disulfonic acid 0
                                              2-naphthalenesulfonic acid [2-[(2-amino-4-oxo-5-thiazolylidene)methyl]phenyl] ester 0
                                              3,3'-(biphenyl-4,4'-diyldidiazene-2,1-diyl)bis(4-aminonaphthalene-1-sulfonic acid) + 2
                                              4,5-dihydroxy-3-(phenyldiazenyl)naphthalene-2,7-disulfonic acid 0
                                              4-[(2,4-dimethylphenyl)diazenyl]-3-hydroxynaphthalene-2,7-disulfonic acid 0
                                              4-amino-3-hydroxynaphthalene-1-sulfonic acid 0
                                              4-hydroxy-3-[(2-methoxyphenyl)diazenyl]naphthalene-1-sulfonic acid 0
                                              5-acetamido-4-hydroxy-3-(phenyldiazenyl)naphthalene-2,7-disulfonic acid 0
                                              7-hydroxy-8-[(E)-phenyldiazenyl]naphthalene-1,3-disulfonic acid 0
                                              7-hydroxy-8-[(naphthalen-1-yl)diazenyl]naphthalene-1,3-disulfonic acid 0
                                              7-hydroxy-8-\{[4-(phenyldiazenyl)phenyl]diazenyl\}naphthalene-1,3-disulfonic acid 0
                                              8-Phenylamino-naphthalene-1-sulfonic acid anion 0
                                              8-anilinonaphthalene-1-sulfonic acid 11
                                              8-oxo-7-[(6-sulfo-2-naphthalenyl)hydrazinylidene]-5-quinolinesulfonic acid 0
                                              Evans blue free acid 0
                                              Reactive Red 6 hapten + 0
                                              Reactive Red 6 hapten copper complex 0
                                              Reactive red 120 0
                                              Sirius red 4B (acid form) 0
                                              Sirius red F3B (acid form) 0
                                              aminonaphthalenesulfonic acid + 0
                                              benzo scarlet 4BNS free acid 0
                                              chromotropic acid 0
                                              dibunic acid 0
                                              ethyl dibunate 0
                                              flavianic acid 0
                                              naphthalene-1,3,5-trisulfonic acid + 31
                                              naphthalene-1,3,6-trisulfonic acid 0
                                              naphthalene-1,5-disulfonic acid 0
                                              naphthalene-1,6-disulfonic acid 0
                                              naphthalene-1-sulfonic acid 0
                                              naphthalene-2,6-disulfonic acid 0
                                              naphthalene-2,7-disulfonic acid 0
                                              naphthalene-2-sulfonic acid 0
                                              suramin 31
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.