|
|
| G
|
Tp53
|
tumor protein p53
|
affects activity
|
ISO
|
7-amino-4-hydroxy-2-naphthalenesulfonic acid affects the activity of TP53 protein; 7-amino-4-hydroxy-2-naphthalenesulfonic acid metabolite affects the activity of TP53 protein
|
CTD |
PMID:35435491 |
|
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
|
|
|
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| G
|
Ambp
|
alpha-1-microglobulin/bikunin precursor
|
affects binding
|
ISO
|
1-anilino-8-naphthalenesulfonate binds to AMBP protein
|
CTD |
PMID:16461020 |
|
NCBI chr 5:81,583,621...81,593,938
Ensembl chr 5:81,583,622...81,593,850
|
|
| G
|
Apod
|
apolipoprotein D
|
affects binding
|
ISO
|
1-anilino-8-naphthalenesulfonate binds to APOD protein
|
CTD |
PMID:16461020 |
|
NCBI chr11:82,936,216...82,957,264
Ensembl chr11:82,936,038...82,957,263
|
|
| G
|
C8g
|
complement C8 gamma chain
|
affects binding
|
ISO
|
1-anilino-8-naphthalenesulfonate binds to C8G protein
|
CTD |
PMID:16461020 |
|
NCBI chr 3:28,718,648...28,720,232
|
|
| G
|
Gsta1
|
glutathione S-transferase alpha 1
|
affects binding
|
ISO
|
1-anilino-8-naphthalenesulfonate binds to GSTA1 protein
|
CTD |
PMID:14690442 |
|
NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:31,199,888...31,211,528
|
|
| G
|
Lcn1
|
lipocalin 1
|
affects binding
|
ISO
|
1-anilino-8-naphthalenesulfonate binds to LCN1 protein
|
CTD |
PMID:16461020 |
|
NCBI chr 3:29,930,943...29,935,418
|
|
| G
|
Lcn2
|
lipocalin 2
|
affects binding
|
ISO
|
1-anilino-8-naphthalenesulfonate binds to LCN2 protein
|
CTD |
PMID:16461020 |
|
NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842
|
|
| G
|
Obp2a
|
odorant binding protein 2A
|
affects binding
|
ISO
|
1-anilino-8-naphthalenesulfonate binds to OBP2A protein
|
CTD |
PMID:16461020 |
|
NCBI chr 3:28,904,024...28,907,391
Ensembl chr 3:28,902,876...28,907,389
|
|
| G
|
Orm1
|
orosomucoid 1
|
affects binding
|
ISO
|
1-anilino-8-naphthalenesulfonate binds to ORM1 protein
|
CTD |
PMID:16461020 |
|
NCBI chr 5:81,788,509...81,791,661
Ensembl chr 5:81,788,395...81,791,667
|
|
| G
|
Paep
|
progestagen associated endometrial protein
|
affects binding
|
ISO
|
1-anilino-8-naphthalenesulfonate binds to PAEP protein
|
CTD |
PMID:16461020 |
|
NCBI chr 3:28,929,252...28,932,592
|
|
| G
|
Ptgds
|
prostaglandin D2 synthase
|
affects binding
|
ISO
|
1-anilino-8-naphthalenesulfonate binds to PTGDS protein
|
CTD |
PMID:16461020 |
|
NCBI chr 3:28,680,044...28,682,978
Ensembl chr 3:28,680,044...28,682,978
|
|
| G
|
Ttr
|
transthyretin
|
affects binding multiple interactions
|
ISO
|
1-anilino-8-naphthalenesulfonate binds to TTR protein 3,3'-dichlorobiphenyl metabolite inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]; 3,4-dichlorinated biphenyl metabolite inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]; 4-chlorobiphenyl metabolite inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]; Thyroxine inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]
|
CTD |
PMID:23584369 |
|
NCBI chr18:12,216,684...12,225,972
Ensembl chr18:12,216,732...12,225,969
|
|
|
|
| G
|
Calca
|
calcitonin-related polypeptide alpha
|
multiple interactions
|
EXP
|
Suramin inhibits the reaction [Adenosine Triphosphate promotes the reaction [Protons results in increased secretion of CALCA protein]]
|
CTD |
PMID:12044622 |
|
NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529
|
|
| G
|
Casp1
|
caspase 1
|
multiple interactions
|
EXP
|
Suramin inhibits the reaction [Glucose results in increased activity of CASP1 protein]
|
CTD |
PMID:21832250 |
|
NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275
|
|
| G
|
Casp3
|
caspase 3
|
multiple interactions
|
ISO
|
Suramin inhibits the reaction [Adenosine Triphosphate results in increased expression of CASP3]; Suramin inhibits the reaction [Clodronic Acid results in increased expression of CASP3]
|
CTD |
PMID:19448140 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
|
|
| G
|
Chrna7
|
cholinergic receptor nicotinic alpha 7 subunit
|
increases expression
|
ISO
|
Suramin results in increased expression of CHRNA7 protein
|
CTD |
PMID:23516405 |
|
NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:126,123,425...126,446,858
|
|
| G
|
Creb1
|
cAMP responsive element binding protein 1
|
multiple interactions
|
ISO
|
Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein]
|
CTD |
PMID:18612546 |
|
NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339
|
|
| G
|
Cyp1a2
|
cytochrome P450, family 1, subfamily a, polypeptide 2
|
decreases activity
|
ISO
|
Suramin results in decreased activity of CYP1A2 protein
|
CTD |
PMID:11124226 |
|
NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149
|
|
| G
|
Cyp1b1
|
cytochrome P450, family 1, subfamily b, polypeptide 1
|
multiple interactions
|
ISO
|
Suramin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]
|
CTD |
PMID:22167199 |
|
NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142
|
|
| G
|
Cyp2c6
|
cytochrome P450, family 2, subfamily C, polypeptide 6
|
decreases activity
|
ISO
|
Suramin results in decreased activity of CYP2C19 protein
|
CTD |
PMID:11124226 |
|
NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798
|
|
| G
|
Egfr
|
epidermal growth factor receptor
|
multiple interactions
|
EXP
|
Suramin inhibits the reaction [sodium arsenite results in increased phosphorylation of EGFR protein]
|
CTD |
PMID:9710602 |
|
NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358
|
|
| G
|
Fgf2
|
fibroblast growth factor 2
|
increases expression
|
ISO
|
Suramin results in increased expression of FGF2
|
CTD |
PMID:8394679 |
|
NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493
|
|
| G
|
Fgf5
|
fibroblast growth factor 5
|
increases expression
|
ISO
|
Suramin results in increased expression of FGF5
|
CTD |
PMID:8394679 |
|
NCBI chr14:11,627,906...11,650,243
Ensembl chr14:11,627,906...11,650,243
|
|
| G
|
Fgf7
|
fibroblast growth factor 7
|
affects localization multiple interactions
|
ISO
|
Suramin affects the localization of FGF7 protein Suramin inhibits the reaction [FGF7 protein binds to FGFR2 protein]
|
CTD |
PMID:15733146 |
|
NCBI chr 3:133,734,557...133,786,678
Ensembl chr 3:133,734,673...133,786,328
|
|
| G
|
Fgfr2
|
fibroblast growth factor receptor 2
|
multiple interactions
|
ISO
|
Suramin inhibits the reaction [FGF7 protein binds to FGFR2 protein]
|
CTD |
PMID:15733146 |
|
NCBI chr 1:194,175,703...194,280,914
Ensembl chr 1:194,175,705...194,280,914
|
|
| G
|
Fmr1
|
fragile X messenger ribonucleoprotein 1
|
multiple interactions
|
ISO
|
Suramin inhibits the reaction [Poly I-C results in decreased expression of FMR1 protein]
|
CTD |
PMID:23516405 |
|
NCBI chr X:152,284,857...152,322,686
Ensembl chr X:152,284,841...152,322,675
|
|
| G
|
Gusb
|
glucuronidase, beta
|
decreases activity
|
EXP
|
suramin decreases activity of beta-glucuronidase in rat spleen, kidney, and lung
|
RGD |
PMID:2879381 |
RGD:42724461 |
NCBI chr12:32,337,281...32,350,838
Ensembl chr12:32,334,075...32,363,024
|
|
| G
|
Hpgds
|
hematopoietic prostaglandin D synthase
|
decreases activity
|
ISO
|
Suramin results in decreased activity of HPGDS protein
|
CTD |
PMID:25603235 |
|
NCBI chr 4:95,698,265...95,727,733
Ensembl chr 4:95,702,392...95,938,501
|
|
| G
|
Il10
|
interleukin 10
|
multiple interactions decreases activity
|
ISO
|
Suramin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of IL10 protein] Suramin results in decreased activity of IL10 protein
|
CTD |
PMID:15914193 |
|
NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580
|
|
| G
|
Il12b
|
interleukin 12B
|
increases expression
|
ISO
|
Suramin results in increased expression of IL12B protein
|
CTD |
PMID:15914193 |
|
NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194
|
|
| G
|
Il6
|
interleukin 6
|
multiple interactions
|
ISO
|
Suramin inhibits the reaction [Adenosine Triphosphate results in increased expression of IL6 protein]; Suramin inhibits the reaction [Silicon Dioxide analog results in increased expression of IL6 protein]; Suramin inhibits the reaction [Uridine Triphosphate results in increased expression of IL6 protein] Suramin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
|
CTD |
PMID:24793913 PMID:24849676 |
|
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
|
|
| G
|
Lmna
|
lamin A/C
|
multiple interactions
|
ISO
|
Suramin inhibits the reaction [LMNA protein binds to and results in increased activity of SIRT1 protein]
|
CTD |
PMID:23217256 |
|
NCBI chr 2:176,237,564...176,265,301
Ensembl chr 2:176,237,564...176,288,072
|
|
| G
|
Mapk1
|
mitogen activated protein kinase 1
|
multiple interactions
|
ISO EXP
|
Suramin inhibits the reaction [arsenic acid results in increased activity of MAPK1 protein]; Suramin inhibits the reaction [arsenite results in increased activity of MAPK1 protein]; Suramin inhibits the reaction [Estradiol results in increased phosphorylation of MAPK1 protein]; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK1 protein] Suramin inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of MAPK1 protein] Suramin inhibits the reaction [2,6-di-tert-butyl-4-hydroperoxy-4-methyl-2,5-cyclohexadienone results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Suramin inhibits the reaction [Poly I-C results in decreased phosphorylation of MAPK1 protein]
|
CTD |
PMID:8758915 PMID:9710602 PMID:14674888 PMID:15930183 PMID:18612546 PMID:23516405 More...
|
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
|
|
| G
|
Mapk3
|
mitogen activated protein kinase 3
|
multiple interactions
|
ISO EXP
|
Suramin inhibits the reaction [arsenic acid results in increased activity of MAPK3 protein]; Suramin inhibits the reaction [arsenite results in increased activity of MAPK3 protein]; Suramin inhibits the reaction [Estradiol results in increased phosphorylation of MAPK3 protein]; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein] Suramin inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of MAPK3 protein] Suramin inhibits the reaction [Poly I-C results in decreased phosphorylation of MAPK3 protein]
|
CTD |
PMID:9710602 PMID:14674888 PMID:15930183 PMID:18612546 PMID:23516405 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
|
|
| G
|
P2rx1
|
purinergic receptor P2X 1
|
affects binding
|
EXP
|
Suramin binds to P2rx1 protein
|
RGD |
PMID:12237343 |
RGD:727431 |
NCBI chr10:58,117,107...58,132,167
Ensembl chr10:58,117,088...58,132,164
|
|
| G
|
P2rx2
|
purinergic receptor P2X 2
|
affects activity
|
EXP
|
suramin affects activity of rat P2x2 receptor in transfected glial cells
|
RGD |
PMID:16388598 |
RGD:1642662 |
NCBI chr12:51,999,107...52,002,627
Ensembl chr12:51,999,372...52,002,627
|
|
| G
|
P2rx3
|
purinergic receptor P2X 3
|
multiple interactions
|
EXP
|
Suramin inhibits the reaction [Cyclophosphamide results in increased expression of P2RX3 protein]
|
CTD |
PMID:23666265 |
|
NCBI chr 3:90,487,506...90,531,315
Ensembl chr 3:90,487,506...90,531,794
|
|
| G
|
P2rx5
|
purinergic receptor P2X 5
|
affects transport
|
EXP
|
Suramin affects transport ion flux of P2rx5 receptor
|
RGD |
PMID:12237343 |
RGD:727431 |
NCBI chr10:58,276,329...58,291,108
Ensembl chr10:58,276,257...58,287,935
|
|
| G
|
P2rx7
|
purinergic receptor P2X 7
|
multiple interactions
|
ISO
|
Suramin inhibits the reaction [Poly I-C results in decreased expression of P2RX7 protein]
|
CTD |
PMID:23516405 |
|
NCBI chr12:39,550,531...39,594,984
Ensembl chr12:39,540,567...39,595,193
|
|
| G
|
P2ry2
|
purinergic receptor P2Y2
|
decreases activity multiple interactions
|
EXP ISO
|
Suramin results in decreased activity of P2RY2 protein Suramin inhibits the reaction [Poly I-C results in decreased expression of P2RY2 protein]
|
CTD |
PMID:15654852 PMID:23516405 |
|
NCBI chr 1:164,764,119...164,779,578
Ensembl chr 1:164,759,213...164,781,852
|
|
| G
|
Ptgs2
|
prostaglandin-endoperoxide synthase 2
|
multiple interactions
|
ISO
|
JTE 013 promotes the reaction [Suramin inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; Suramin inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; Suramin promotes the reaction [JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]
|
CTD |
PMID:18612546 |
|
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
|
|
| G
|
Shc1
|
SHC adaptor protein 1
|
multiple interactions increases expression
|
EXP ISO
|
Suramin inhibits the reaction [sodium arsenite results in increased phosphorylation of SHC1 protein] Suramin results in increased expression of SHC1 mRNA; Suramin results in increased expression of SHC1 protein
|
CTD |
PMID:9710602 PMID:21778425 |
|
NCBI chr 2:177,135,649...177,147,257
Ensembl chr 2:177,135,659...177,147,914
|
|
| G
|
Sirt1
|
sirtuin 1
|
multiple interactions
|
ISO
|
Suramin inhibits the reaction [LMNA protein binds to and results in increased activity of SIRT1 protein]; Suramin results in decreased activity of [SIRT1 protein results in decreased acetylation of TP53 protein] [Suramin results in decreased activity of SIRT1 protein] which results in decreased susceptibility to resveratrol
|
CTD |
PMID:18482975 PMID:23217256 PMID:24252177 |
|
NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000
|
|
| G
|
Tacr1
|
tachykinin receptor 1
|
multiple interactions
|
EXP
|
Suramin inhibits the reaction [Cyclophosphamide results in increased expression of TACR1 protein]
|
CTD |
PMID:23666265 |
|
NCBI chr 4:116,478,617...116,647,492
Ensembl chr 4:116,478,617...116,647,492
|
|
| G
|
Tnf
|
tumor necrosis factor
|
increases expression
|
ISO
|
Suramin results in increased expression of TNF protein
|
CTD |
PMID:15914193 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
|
|
| G
|
Tp53
|
tumor protein p53
|
multiple interactions
|
ISO
|
Suramin results in decreased activity of [SIRT1 protein results in decreased acetylation of TP53 protein]
|
CTD |
PMID:18482975 |
|
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
|
|
| G
|
Vdr
|
vitamin D receptor
|
multiple interactions
|
ISO
|
Suramin inhibits the reaction [Estradiol results in increased expression of VDR protein]
|
CTD |
PMID:15930183 |
|
NCBI chr 7:130,864,764...130,916,757
Ensembl chr 7:130,866,745...130,916,757
|
|