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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hispidin
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Accession:CHEBI:36332 term browser browse the term
Definition:Fungal metabolite first found in basidiomycete Inonotus hispidus (formerly Polyporus hispidus).
Synonyms:exact_synonym: 6-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-4-hydroxy-2H-pyran-2-one
 related_synonym: 6-(3,4-dihydroxystyryl)-4-hydroxy-2-pyrone;   6-[(E)-2-(3,4-dihydroxyphenyl)vinyl]-4-hydroxy-2H-pyran-2-one;   Formula=C13H10O5;   InChI=1S/C13H10O5/c14-9-6-10(18-13(17)7-9)3-1-8-2-4-11(15)12(16)5-8/h1-7,14-16H/b3-1+;   InChIKey=SGJNQVTUYXCBKH-HNQUOIGGSA-N;   SMILES=OC1=CC(=O)OC(\\C=C\\C2=CC=C(O)C(O)=C2)=C1
 xref: Beilstein:1288087;   CAS:555-55-5;   Chemspider:13975015;   HMDB:HMDB0253181;   KNApSAcK:C00043575
 xref_mesh: MESH:C007946
 xref: PMID:29345559;   PMID:32321407;   PMID:34335912;   PMID:35067200;   PMID:565401;   PMID:9088624;   Wikipedia:Hispidin
 cyclic_relationship: is_conjugate_acid_of CHEBI:190288



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hispidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp9 caspase 9 multiple interactions
increases activity
EXP hispidin inhibits the reaction [Doxorubicin results in increased activity of CASP9 protein]
hispidin results in increased activity of CASP9 protein
CTD PMID:26318906
G Shc1 SHC adaptor protein 1 multiple interactions EXP hispidin inhibits the reaction [Doxorubicin results in increased expression of and results in decreased phosphorylation of and affects the localization of SHC1 protein] CTD PMID:26318906 NCBI chr 2:177,135,649...177,147,257 JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO hispidin inhibits the reaction [Cyclosporine results in increased phosphorylation of and results in increased activity of SMAD2 protein] CTD PMID:22155090 NCBI chr18:72,124,792...72,193,345 JBrowse link

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  CHEBI ontology 19898
    role 19869
      chemical role 19500
        antioxidant 16189
          hispidin 3
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  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            heteroorganic entity 19535
                              organochalcogen compound 19296
                                organooxygen compound 19213
                                  ester 17485
                                    carboxylic ester 16770
                                      lactone 13312
                                        delta-lactone 4213
                                          2-pyranones 772
                                            hispidin 3
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