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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:glycerophosphoinositol
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Accession:CHEBI:36315 term browser browse the term
Definition:Any glycerophospholipid having the polar alcohol inositol esterified to the phosphate group at the sn-3 position of the glycerol backbone.
Synonyms:related_synonym: GPI;   glycerophosphoinositols
 alt_id: CHEBI:26040;   CHEBI:35770
 xref: PMID:14706866


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lipoarabinomannan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CSF2 colony stimulating factor 2 multiple interactions EXP CSF2 protein promotes the reaction [lipoarabinomannan results in increased secretion of CXCL8 protein] CTD PMID:12176910 NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions
increases secretion
EXP CSF2 protein promotes the reaction [lipoarabinomannan results in increased secretion of CXCL8 protein] CTD PMID:12176910 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 decreases expression EXP lipoarabinomannan results in decreased expression of CXCR2 protein CTD PMID:10950785 NCBI chr 2:218,125,294...218,137,253
Ensembl chr 2:218,125,289...218,137,251
JBrowse link
G IL12B interleukin 12B multiple interactions ISO lipoarabinomannan inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B protein] CTD PMID:16263713 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
JBrowse link
G IRAK1 interleukin 1 receptor associated kinase 1 multiple interactions ISO lipoarabinomannan inhibits the reaction [IRAK1 protein binds to TRAF6 protein] CTD PMID:16263713 NCBI chr  X:154,010,507...154,019,984
Ensembl chr  X:154,010,506...154,019,902
JBrowse link
G IRAK3 interleukin 1 receptor associated kinase 3 increases expression
increases expression
ISO lipoarabinomannan results in increased expression of IRAK3 protein
Lipoarabinomannan increases expression of Irak3 mRNA and protein in macrophages
CTD PMID:16263713, PMID:16263713 RGD:36049804 NCBI chr12:66,189,214...66,254,622
Ensembl chr12:66,189,195...66,254,622
JBrowse link
G MMP9 matrix metallopeptidase 9 increases activity ISO lipoarabinomannan results in increased activity of MMP9 protein CTD PMID:11839551 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions ISO lipoarabinomannan results in decreased localization of and results in decreased activity of NFKB1 protein CTD PMID:16263713 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302
JBrowse link
G NFKBIA NFKB inhibitor alpha decreases phosphorylation ISO lipoarabinomannan results in decreased phosphorylation of NFKBIA protein CTD PMID:16263713 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G REL REL proto-oncogene, NF-kB subunit multiple interactions ISO lipoarabinomannan results in decreased localization of and results in decreased activity of REL protein CTD PMID:16263713 NCBI chr 2:60,881,521...60,931,612
Ensembl chr 2:60,881,521...60,931,610
Ensembl chr 2:60,881,521...60,931,610
JBrowse link
G TRAF6 TNF receptor associated factor 6 multiple interactions ISO lipoarabinomannan inhibits the reaction [IRAK1 protein binds to TRAF6 protein] CTD PMID:16263713 NCBI chr11:36,483,769...36,510,313
Ensembl chr11:36,483,769...36,510,272
JBrowse link
lipophosphoglycan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD14 CD14 molecule multiple interactions EXP CD14 protein promotes the reaction [lipopeptidophosphoglycan results in increased activity of TLR2 protein]; CD14 protein promotes the reaction [lipopeptidophosphoglycan results in increased activity of TLR4 protein] CTD PMID:15910421 NCBI chr 5:140,631,732...140,633,701
Ensembl chr 5:140,631,728...140,633,701
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of CXCL8 protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] which results in increased secretion of CXCL8 protein CTD PMID:15910421 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G IL10 interleukin 10 multiple interactions EXP [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of IL10 protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] which results in increased secretion of IL10 protein CTD PMID:15910421 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL12B interleukin 12B multiple interactions EXP [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of IL12B protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] which results in increased secretion of IL12B protein CTD PMID:15910421 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions EXP [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] results in increased activity of [NFKB1 protein binds to RELA protein]; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] results in increased activity of [NFKB1 protein binds to RELA protein] CTD PMID:15910421 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] results in increased activity of [NFKB1 protein binds to RELA protein]; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] results in increased activity of [NFKB1 protein binds to RELA protein] CTD PMID:15910421 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G TLR2 toll like receptor 2 multiple interactions
increases response to substance
EXP
ISO
[lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] results in increased activity of [NFKB1 protein binds to RELA protein]; [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of CXCL8 protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of IL10 protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of IL12B protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of TNF protein; CD14 protein promotes the reaction [lipopeptidophosphoglycan results in increased activity of TLR2 protein]; lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein
TLR2 protein results in increased susceptibility to lipopeptidophosphoglycan
CTD PMID:15910421 NCBI chr 4:153,684,080...153,710,643
Ensembl chr 4:153,684,070...153,706,260
Ensembl chr 4:153,684,070...153,706,260
JBrowse link
G TLR4 toll like receptor 4 multiple interactions
increases response to substance
EXP
ISO
[lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] results in increased activity of [NFKB1 protein binds to RELA protein]; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] which results in increased secretion of CXCL8 protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] which results in increased secretion of IL10 protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] which results in increased secretion of IL12B protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] which results in increased secretion of TNF protein; CD14 protein promotes the reaction [lipopeptidophosphoglycan results in increased activity of TLR4 protein]; lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein
TLR4 protein results in increased susceptibility to lipopeptidophosphoglycan
CTD PMID:15910421 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of TNF protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] which results in increased secretion of TNF protein CTD PMID:15910421 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
phosphatidylinositol 4-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2 coagulation factor II, thrombin multiple interactions
increases abundance
EXP resveratrol inhibits the reaction [F2 protein results in increased abundance of phosphatidylinositol 4-phosphate] CTD PMID:16051184 NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506
Ensembl chr11:46,719,196...46,739,506
JBrowse link
G NCS1 neuronal calcium sensor 1 increases phosphorylation
multiple interactions
ISO NCS1 protein results in increased phosphorylation of phosphatidylinositol 4-phosphate
wortmannin inhibits the reaction [NCS1 protein results in increased phosphorylation of phosphatidylinositol 4-phosphate]
CTD PMID:12471042 NCBI chr 9:130,172,404...130,237,303
Ensembl chr 9:130,172,404...130,237,303
JBrowse link
phosphatidylinositol dimannoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL6 interleukin 6 multiple interactions ISO [phosphatidylinositol dimannoside analog co-treated with Thioglycolates] results in increased expression of IL6 protein; phosphatidylinositol dimannoside analog inhibits the reaction [[Lipopolysaccharides co-treated with Thioglycolates] results in increased expression of IL6 protein]; phosphatidylinositol dimannoside analog promotes the reaction [[Lipopolysaccharides co-treated with Thioglycolates] results in increased expression of IL6 protein]; TLR4 gene mutant form inhibits the reaction [[phosphatidylinositol dimannoside analog co-treated with Thioglycolates] results in increased expression of IL6 protein] CTD PMID:21936536 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G TLR4 toll like receptor 4 multiple interactions ISO TLR4 gene mutant form inhibits the reaction [[phosphatidylinositol dimannoside analog co-treated with Thioglycolates] results in increased expression of IL6 protein] CTD PMID:21936536 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24481
    role 24392
      biological role 24359
        osmolyte 2035
          glycerol 1760
            glycerolipid 269
              glycerophospholipid 206
                glycerophosphoinositol 20
                  1-acylglycerophosphoinositol + 0
                  1-archaetidyl-D-myo-inositol 0
                  2-acylglycerophosphoinositol + 0
                  6-O-(1-O-stearoyl-sn-glycero-3-phosphono)-1D-myo-inositol 0
                  alkyl,acyl-sn-glycero-3-phospho-1D-myo-inositol + 0
                  glycerophosphoinositol phosphate + 0
                  lysophosphatidyl-1D-myo-inositol + 0
                  phosphatidylinositol + 20
                  sn-Glycero-3-phosphoinositol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 24481
    subatomic particle 24438
      composite particle 24438
        hadron 24438
          baryon 24438
            nucleon 24438
              atomic nucleus 24438
                atom 24438
                  main group element atom 24295
                    p-block element atom 24295
                      chalcogen 23359
                        oxygen atom 23237
                          oxygen molecular entity 23237
                            hydroxides 22467
                              oxoacid 21613
                                pnictogen oxoacid 10810
                                  phosphorus oxoacid 9595
                                    phosphoric acids 8312
                                      phosphoric acid 8312
                                        phosphoric acid derivative 7981
                                          phosphate 7981
                                            organic phosphate 7980
                                              phospholipid 302
                                                glycerophospholipid 206
                                                  glycerophosphoinositol 20
                                                    1-acylglycerophosphoinositol + 0
                                                    1-archaetidyl-D-myo-inositol 0
                                                    2-acylglycerophosphoinositol + 0
                                                    6-O-(1-O-stearoyl-sn-glycero-3-phosphono)-1D-myo-inositol 0
                                                    alkyl,acyl-sn-glycero-3-phospho-1D-myo-inositol + 0
                                                    glycerophosphoinositol phosphate + 0
                                                    lysophosphatidyl-1D-myo-inositol + 0
                                                    phosphatidylinositol + 20
                                                    sn-Glycero-3-phosphoinositol 0
paths to the root