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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cyclic tetrapyrrole
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Accession:CHEBI:36309 term browser browse the term
Synonyms:exact_synonym: macrocyclic tetrapyrroles
 related_synonym: cyclic tetrapyrroles;   macrocyclic tetrapyrrole


show annotations for term's descendants           Sort by:
 
cobamamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gstp1 glutathione S-transferase, pi 1 multiple interactions ISO cobamamide inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985 		JBrowse link
coproporphyrinogen III term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpox coproporphyrinogen oxidase multiple interactions
decreases carboxylation		 ISO Mercury inhibits the reaction [CPOX protein results in decreased carboxylation of coproporphyrinogen III] CTD PMID:19339664 NCBI chr16:58,490,571...58,500,754
Ensembl chr16:58,490,655...58,537,999 		JBrowse link
cyanocob(III)alamin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A decreases expression
multiple interactions		 ISO Vitamin B 12 results in decreased expression of ABCB1 mRNA; Vitamin B 12 results in decreased expression of ABCB1 protein
Vitamin B 12 inhibits the reaction [Methotrexate results in increased expression of ABCB1 mRNA]		 CTD PMID:17982279 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abcc4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of ABCC4 mRNA CTD PMID:33549593 NCBI chr14:118,720,104...118,945,475
Ensembl chr14:118,720,104...118,943,631 		JBrowse link
G Abcd4 ATP-binding cassette, sub-family D (ALD), member 4 affects metabolic processing ISO ABCD4 protein affects the metabolism of Vitamin B 12 CTD PMID:22922874 NCBI chr12:84,648,634...84,664,259
Ensembl chr12:84,648,238...84,664,187 		JBrowse link
G Acaca acetyl-Coenzyme A carboxylase alpha multiple interactions ISO [Choline co-treated with Betaine co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with Dietary Fats co-treated with Dietary Sucrose] results in increased expression of ACACA mRNA CTD PMID:22648174 NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477 		JBrowse link
G Acacb acetyl-Coenzyme A carboxylase beta multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of ACACB mRNA CTD PMID:33549593 NCBI chr 5:114,284,378...114,388,822
Ensembl chr 5:114,284,596...114,388,822 		JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions EXP Vitamin B 12 inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 mRNA] CTD PMID:18239293 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990 		JBrowse link
G Adgrg2 adhesion G protein-coupled receptor G2 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of ADGRG2 mRNA CTD PMID:33549593 NCBI chr  X:159,173,315...159,281,072
Ensembl chr  X:159,173,686...159,281,066 		JBrowse link
G Akr1b7 aldo-keto reductase family 1, member B7 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of AKR1B7 mRNA CTD PMID:33549593 NCBI chr 6:34,389,297...34,400,072
Ensembl chr 6:34,389,269...34,400,077 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2, mitochondrial multiple interactions EXP [Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased expression of ALDH2 protein CTD PMID:20118189 NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887 		JBrowse link
G As3mt arsenite methyltransferase multiple interactions ISO Folic Acid promotes the reaction [Vitamin B 12 promotes the reaction [AS3MT protein results in increased methylation of Arsenic]]; Vitamin B 12 promotes the reaction [AS3MT protein results in increased methylation of Arsenic] CTD PMID:20049124 NCBI chr19:46,695,124...46,729,538
Ensembl chr19:46,695,897...46,729,538 		JBrowse link
G Axin1 axin 1 multiple interactions EXP [Folic Acid co-treated with Vitamin B 12 co-treated with Betaine co-treated with Choline] results in increased methylation of AXIN1 gene CTD PMID:16868943 NCBI chr17:26,350,208...26,414,785
Ensembl chr17:26,357,662...26,414,785 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Folic Acid inhibits the reaction [Vitamin B 12 promotes the reaction [Dietary Fats results in increased expression of CASP3 mRNA]]; Vitamin B 12 promotes the reaction [Dietary Fats results in increased expression of CASP3 mRNA] CTD PMID:23935743 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO Folic Acid inhibits the reaction [Vitamin B 12 promotes the reaction [Dietary Fats results in increased expression of CASP8 mRNA]]; Vitamin B 12 promotes the reaction [Dietary Fats results in increased expression of CASP8 mRNA] CTD PMID:23935743 NCBI chr 1:58,834,398...58,886,662
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Cat catalase multiple interactions EXP
ISO		 [Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased activity of CAT protein
Vitamin B 12 promotes the reaction [Folic Acid inhibits the reaction [arsenic trioxide results in decreased activity of CAT protein]]		 CTD PMID:16214333 PMID:20118189 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Cbs cystathionine beta-synthase multiple interactions ISO [Fatty Acids, Omega-3 co-treated with Folic Acid co-treated with Vitamin B 12 deficiency] results in increased expression of CBS mRNA; [Fatty Acids, Omega-3 co-treated with Vitamin B 12 deficiency] results in increased expression of CBS mRNA; [Folic Acid co-treated with Vitamin B 12 deficiency] results in increased expression of CBS mRNA CTD PMID:25003120 NCBI chr17:31,831,597...31,856,207
Ensembl chr17:31,827,868...31,856,212 		JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 multiple interactions ISO [Choline co-treated with Betaine co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of CCL2 mRNA CTD PMID:22648174 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Cd40 CD40 antigen multiple interactions ISO [Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in decreased expression of CD40 mRNA CTD PMID:30116142 NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CDK1 mRNA CTD PMID:33549593 NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768 		JBrowse link
G Ces2c carboxylesterase 2C multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CES2C mRNA CTD PMID:33549593 NCBI chr 8:105,573,700...105,581,115
Ensembl chr 8:105,573,700...105,581,115 		JBrowse link
G Clcf1 cardiotrophin-like cytokine factor 1 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CLCF1 mRNA CTD PMID:33549593 NCBI chr19:4,264,292...4,273,559
Ensembl chr19:4,264,292...4,273,544 		JBrowse link
G Crp C-reactive protein, pentraxin-related multiple interactions ISO [Folic Acid co-treated with Riboflavin co-treated with Vitamin B 6 co-treated with Vitamin B 12] results in decreased expression of CRP protein; [Vitamin E co-treated with Ascorbic Acid co-treated with Folic Acid co-treated with Riboflavin co-treated with Vitamin B 6 co-treated with Vitamin B 12] results in decreased expression of CRP protein CTD PMID:16517955 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598 		JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CYP26A1 mRNA CTD PMID:33549593 NCBI chr19:37,686,186...37,689,984
Ensembl chr19:37,686,246...37,689,984 		JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CYP2B10 mRNA CTD PMID:33549593 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049 		JBrowse link
G Cyp2c55 cytochrome P450, family 2, subfamily c, polypeptide 55 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CYP2C55 mRNA CTD PMID:33549593 NCBI chr19:38,995,384...39,031,134
Ensembl chr19:38,995,463...39,031,137 		JBrowse link
G Cyp2d9 cytochrome P450, family 2, subfamily d, polypeptide 9 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CYP2D9 mRNA; [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in increased expression of CYP2D9 mRNA CTD PMID:33549593 NCBI chr15:82,336,578...82,341,028
Ensembl chr15:82,317,638...82,341,046 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate] inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein] CTD PMID:20118189 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Cyp4a10 cytochrome P450, family 4, subfamily a, polypeptide 10 multiple interactions EXP [Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased expression of CYP4A10 protein CTD PMID:20118189 NCBI chr 4:115,375,484...115,390,846
Ensembl chr 4:115,375,461...115,390,846 		JBrowse link
G Depp1 DEPP1 autophagy regulator multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of DEPP1 mRNA CTD PMID:33549593 NCBI chr 6:116,627,645...116,629,808
Ensembl chr 6:116,627,570...116,629,755 		JBrowse link
G E2f8 E2F transcription factor 8 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of E2F8 mRNA CTD PMID:33549593 NCBI chr 7:48,516,177...48,531,821
Ensembl chr 7:48,516,177...48,531,344 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of EGFR mRNA CTD PMID:33549593 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158 		JBrowse link
G Egr1 early growth response 1 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of EGR1 mRNA CTD PMID:33549593 NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037 		JBrowse link
G Esco2 establishment of sister chromatid cohesion N-acetyltransferase 2 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of ESCO2 mRNA CTD PMID:33549593 NCBI chr14:66,056,476...66,071,418
Ensembl chr14:66,056,487...66,071,443 		JBrowse link
G Fabp5 fatty acid binding protein 5, epidermal multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of FABP5 mRNA CTD PMID:33549593 NCBI chr 3:10,077,645...10,081,670
Ensembl chr 3:10,077,608...10,081,667 		JBrowse link
G Fads1 fatty acid desaturase 1 multiple interactions ISO [Fatty Acids, Omega-3 co-treated with Vitamin B 12 deficiency] results in decreased expression of FADS1 mRNA; [Folic Acid co-treated with Vitamin B 12 deficiency] results in decreased expression of FADS1 mRNA; [Vitamin B 12 deficiency co-treated with Fatty Acids, Omega-3] results in decreased activity of FADS1 protein; Folic Acid inhibits the reaction [[Fatty Acids, Omega-3 co-treated with Vitamin B 12 deficiency] results in decreased expression of FADS1 mRNA]; Folic Acid promotes the reaction [[Vitamin B 12 deficiency co-treated with Fatty Acids, Omega-3] results in decreased activity of FADS1 protein]; Vitamin B 12 deficiency promotes the reaction [Folic Acid results in increased activity of FADS1 protein] CTD PMID:22133376 NCBI chr19:10,160,245...10,174,238
Ensembl chr19:10,160,252...10,174,241 		JBrowse link
G Fads2 fatty acid desaturase 2 multiple interactions ISO [Vitamin B 12 deficiency co-treated with Fatty Acids, Omega-3] results in decreased activity of FADS2 protein; [Vitamin B 12 deficiency co-treated with Folic Acid] results in decreased activity of FADS2 protein; Folic Acid inhibits the reaction [[Vitamin B 12 deficiency co-treated with Fatty Acids, Omega-3] results in decreased activity of FADS2 protein] CTD PMID:22133376 NCBI chr19:10,040,129...10,078,867
Ensembl chr19:10,040,129...10,079,110 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO [Choline co-treated with Betaine co-treated with Vitamin B 12 co-treated with Folic Acid] affects the reaction [[Dietary Fats co-treated with Dietary Sucrose] affects the methylation of FASN promoter] CTD PMID:22648174 NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373 		JBrowse link
G Folh1 folate hydrolase 1 multiple interactions ISO Vitamin B 12 affects the reaction [FOLH1 gene SNP affects the susceptibility to and affects the metabolism of Arsenic] CTD PMID:29459232 NCBI chr 7:86,365,733...86,425,171
Ensembl chr 7:86,368,185...86,425,151 		JBrowse link
G Fut2 fucosyltransferase 2 affects abundance ISO FUT2 gene polymorphism affects the abundance of Vitamin B 12 CTD PMID:18776911 NCBI chr 7:45,298,015...45,315,818
Ensembl chr 7:45,298,015...45,315,818 		JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible 45 beta multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of GADD45B mRNA CTD PMID:33549593 NCBI chr10:80,765,925...80,768,038
Ensembl chr10:80,765,907...80,768,038 		JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible 45 gamma multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of GADD45G mRNA CTD PMID:33549593 NCBI chr13:52,000,711...52,002,511
Ensembl chr13:52,000,714...52,002,504 		JBrowse link
G Gck glucokinase multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in increased expression of GCK mRNA CTD PMID:33549593 NCBI chr11:5,850,816...5,900,081
Ensembl chr11:5,850,820...5,900,081 		JBrowse link
G Gna14 guanine nucleotide binding protein, alpha 14 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of GNA14 mRNA CTD PMID:33549593 NCBI chr19:16,413,031...16,590,706
Ensembl chr19:16,413,126...16,588,184 		JBrowse link
G Gpcpd1 glycerophosphocholine phosphodiesterase 1 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of GPCPD1 mRNA CTD PMID:33549593 NCBI chr 2:132,371,002...132,420,173
Ensembl chr 2:132,371,002...132,429,649 		JBrowse link
G Gsta1 glutathione S-transferase, alpha 1 (Ya) multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of GSTA5 mRNA; [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in increased expression of GSTA5 mRNA CTD PMID:33549593 NCBI chr 9:78,137,951...78,149,965
Ensembl chr 9:78,137,938...78,149,966 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of GSTM3 mRNA CTD PMID:33549593 NCBI chr 3:107,803,170...107,806,001
Ensembl chr 3:107,803,137...107,806,002 		JBrowse link
G Gucy1a1 guanylate cyclase 1, soluble, alpha 1 multiple interactions ISO 3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine promotes the reaction [Vitamin B 12 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Vitamin B 12 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein] CTD PMID:22171090 NCBI chr 3:81,999,734...82,053,253
Ensembl chr 3:81,999,734...82,053,096 		JBrowse link
G Gucy1b1 guanylate cyclase 1, soluble, beta 1 multiple interactions ISO 3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine promotes the reaction [Vitamin B 12 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Vitamin B 12 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein] CTD PMID:22171090 NCBI chr 3:81,939,311...81,982,018
Ensembl chr 3:81,939,313...81,981,996 		JBrowse link
G Hba-a1 hemoglobin alpha, adult chain 1 affects glycosylation
affects expression		 ISO Vitamin B 12 affects the glycosylation of HBA1 protein
Vitamin B 12 affects the expression of HBA1 protein modified form		 CTD PMID:2299304 NCBI chr11:32,233,672...32,234,486
Ensembl chr11:32,233,511...32,234,465 		JBrowse link
G Il1b interleukin 1 beta increases methylation
multiple interactions		 ISO Vitamin B 12 results in increased methylation of IL1B gene
[Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in decreased expression of IL1B mRNA; [Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in decreased secretion of IL1B protein; [Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased methylation of IL1B gene		 CTD PMID:30116142 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Folic Acid co-treated with Vitamin B 12] inhibits the reaction [arsenic trioxide results in increased expression of IL6 protein] CTD PMID:16214333 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Irs2 insulin receptor substrate 2 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of IRS2 mRNA CTD PMID:33549593 NCBI chr 8:11,034,681...11,058,929
Ensembl chr 8:11,034,681...11,058,458 		JBrowse link
G Itga8 integrin alpha 8 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of ITGA8 mRNA CTD PMID:33549593 NCBI chr 2:12,111,443...12,306,796
Ensembl chr 2:12,111,443...12,306,733 		JBrowse link
G Itgb4 integrin beta 4 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of ITGB4 mRNA CTD PMID:33549593 NCBI chr11:115,865,551...115,899,238
Ensembl chr11:115,865,535...115,899,238 		JBrowse link
G Krt4 keratin 4 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of KRT4 mRNA CTD PMID:33549593 NCBI chr15:101,826,970...101,833,170
Ensembl chr15:101,826,970...101,833,170 		JBrowse link
G Lepr leptin receptor multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of LEPR mRNA CTD PMID:33549593 NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549 		JBrowse link
G Lratd1 LRAT domain containing 1 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of LRATD1 mRNA CTD PMID:33549593 NCBI chr12:14,197,599...14,202,039
Ensembl chr12:14,196,831...14,202,055 		JBrowse link
G Lrrc24 leucine rich repeat containing 24 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of LRRC24 mRNA CTD PMID:33549593 NCBI chr15:76,599,476...76,606,373
Ensembl chr15:76,599,476...76,606,373 		JBrowse link
G Maob monoamine oxidase B decreases activity ISO Vitamin B 12 results in decreased activity of MAOB protein CTD PMID:7430361 NCBI chr  X:16,575,520...16,683,605
Ensembl chr  X:16,575,521...16,683,605 		JBrowse link
G Map4k1 mitogen-activated protein kinase kinase kinase kinase 1 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of MAP4K1 mRNA CTD PMID:33549593 NCBI chr 7:28,681,475...28,702,704
Ensembl chr 7:28,681,475...28,702,704 		JBrowse link
G Mat2a methionine adenosyltransferase II, alpha multiple interactions ISO [Fatty Acids, Omega-3 co-treated with Vitamin B 12 deficiency] results in increased expression of MAT2A mRNA; [Folic Acid co-treated with Vitamin B 12 deficiency] results in increased expression of MAT2A mRNA; Fatty Acids, Omega-3 promotes the reaction [[Folic Acid co-treated with Vitamin B 12 deficiency] results in increased expression of MAT2A mRNA] CTD PMID:25003120 NCBI chr 6:72,409,779...72,416,539
Ensembl chr 6:72,409,782...72,416,541 		JBrowse link
G Mcm5 minichromosome maintenance complex component 5 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of MCM5 mRNA CTD PMID:33549593 NCBI chr 8:75,836,096...75,855,067
Ensembl chr 8:75,836,197...75,855,067 		JBrowse link
G Mcm6 minichromosome maintenance complex component 6 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of MCM6 mRNA CTD PMID:33549593 NCBI chr 1:128,259,312...128,287,442
Ensembl chr 1:128,259,327...128,287,401 		JBrowse link
G Mical1 microtubule associated monooxygenase, calponin and LIM domain containing 1 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of MICAL1 mRNA CTD PMID:33549593 NCBI chr10:41,351,693...41,363,026
Ensembl chr10:41,352,310...41,363,028 		JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of MKI67 mRNA CTD PMID:33549593 NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090 		JBrowse link
G Mmachc methylmalonic aciduria cblC type, with homocystinuria increases metabolic processing
affects binding
decreases metabolic processing		 ISO MMACHC protein results in increased metabolism of Vitamin B 12
Vitamin B 12 analog binds to MMACHC protein; Vitamin B 12 binds to MMACHC protein
MMACHC protein mutant form results in decreased metabolism of Vitamin B 12		 CTD PMID:19700356 NCBI chr 4:116,559,631...116,565,582
Ensembl chr 4:116,559,476...116,565,603 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase multiple interactions
decreases expression		 ISO [Folic Acid co-treated with Vitamin B 12 deficiency] results in decreased expression of MTHFR mRNA; Fatty Acids, Omega-3 inhibits the reaction [Vitamin B 12 deficiency results in decreased expression of MTHFR mRNA] CTD PMID:25003120 NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase affects binding
multiple interactions
increases activity		 ISO Vitamin B 12 binds to MTR protein
[Fatty Acids, Omega-3 co-treated with Vitamin B 12 deficiency] results in decreased expression of MTR mRNA; Fatty Acids, Omega-3 promotes the reaction [Vitamin B 12 deficiency inhibits the reaction [Fatty Acids, Omega-3 results in increased expression of MTR mRNA]]; Vitamin B 12 deficiency inhibits the reaction [Fatty Acids, Omega-3 results in increased expression of MTR mRNA]
Vitamin B 12 results in increased activity of MTR protein		 CTD PMID:17477549 PMID:17982279 PMID:25003120 NCBI chr13:12,196,217...12,273,090
Ensembl chr13:12,197,598...12,272,999 		JBrowse link
G Mycl v-myc avian myelocytomatosis viral oncogene lung carcinoma derived multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of MYCL mRNA CTD PMID:33549593 NCBI chr 4:122,889,381...122,896,283
Ensembl chr 4:122,889,445...122,896,278 		JBrowse link
G Nlrp12 NLR family, pyrin domain containing 12 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of NLRP12 mRNA CTD PMID:33549593 NCBI chr 7:3,267,317...3,298,400
Ensembl chr 7:3,267,458...3,298,370 		JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase multiple interactions ISO [Fatty Acids, Omega-3 co-treated with Vitamin B 12 deficiency] results in increased expression of PEMT mRNA; [Folic Acid co-treated with Vitamin B 12 deficiency] results in increased expression of PEMT mRNA; Fatty Acids, Omega-3 inhibits the reaction [[Folic Acid co-treated with Vitamin B 12 deficiency] results in increased expression of PEMT mRNA] CTD PMID:25003120 NCBI chr11:59,861,440...59,937,394
Ensembl chr11:59,861,440...59,937,315 		JBrowse link
G Per2 period circadian clock 2 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in increased expression of PER2 mRNA CTD PMID:33549593 NCBI chr 1:91,343,699...91,387,072
Ensembl chr 1:91,343,704...91,387,046 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP [Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased expression of PPARA protein CTD PMID:20118189 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions ISO [Folic Acid co-treated with Vitamin B 12] inhibits the reaction [Dietary Fats results in decreased expression of PPARG mRNA]; Vitamin B 12 inhibits the reaction [Dietary Fats results in decreased expression of PPARG mRNA] CTD PMID:23935743 NCBI chr 6:115,337,840...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Ppp1r3g protein phosphatase 1, regulatory subunit 3G multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of PPP1R3G mRNA CTD PMID:33549593 NCBI chr13:36,142,816...36,154,371
Ensembl chr13:36,142,822...36,154,371 		JBrowse link
G Prss8 protease, serine 8 (prostasin) multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of PRSS8 mRNA CTD PMID:33549593 NCBI chr 7:127,524,889...127,529,321
Ensembl chr 7:127,524,888...127,529,276 		JBrowse link
G Rfx4 regulatory factor X, 4 (influences HLA class II expression) multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of RFX4 mRNA CTD PMID:33549593 NCBI chr10:84,591,895...84,742,402
Ensembl chr10:84,591,926...84,742,402 		JBrowse link
G Rgs16 regulator of G-protein signaling 16 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of RGS16 mRNA CTD PMID:33549593 NCBI chr 1:153,616,099...153,621,214
Ensembl chr 1:153,616,095...153,621,214 		JBrowse link
G Rrm2 ribonucleotide reductase M2 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of RRM2 mRNA CTD PMID:33549593 NCBI chr12:24,758,253...24,764,145
Ensembl chr12:24,758,240...24,764,145 		JBrowse link
G S100a8 S100 calcium binding protein A8 (calgranulin A) multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of S100A8 mRNA CTD PMID:33549593 NCBI chr 3:90,576,378...90,577,341
Ensembl chr 3:90,576,285...90,577,342 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 increases methylation
multiple interactions		 ISO Vitamin B 12 results in increased methylation of SERPINE1 gene
[Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SERPINE1 mRNA; [Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased methylation of SERPINE1 gene		 CTD PMID:30116142 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
G Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 multiple interactions EXP Vitamin B 12 inhibits the reaction [Dimethylnitrosamine results in increased expression of SERPINH1 mRNA] CTD PMID:18239293 NCBI chr 7:98,994,582...99,002,480
Ensembl chr 7:98,994,583...99,002,446 		JBrowse link
G Slc25a30 solute carrier family 25, member 30 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of SLC25A30 mRNA CTD PMID:33549593 NCBI chr14:75,994,986...76,024,477
Ensembl chr14:75,997,557...76,024,477 		JBrowse link
G Socs2 suppressor of cytokine signaling 2 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of SOCS2 mRNA CTD PMID:33549593 NCBI chr10:95,219,765...95,253,176
Ensembl chr10:95,221,224...95,253,042 		JBrowse link
G Sult1e1 sulfotransferase family 1E, member 1 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of SULT1E1 mRNA CTD PMID:33549593 NCBI chr 5:87,723,827...87,739,470
Ensembl chr 5:87,723,828...87,739,453 		JBrowse link
G Tcn2 transcobalamin 2 multiple interactions ISO TCN2 protein binds to and results in increased uptake of Vitamin B 12 CTD PMID:14632784 NCBI chr11:3,867,077...3,882,078
Ensembl chr11:3,867,192...3,882,159 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Folic Acid co-treated with Vitamin B 12] inhibits the reaction [arsenic trioxide results in increased expression of TNF protein]
[Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in decreased expression of TNF mRNA; [Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in decreased secretion of TNF protein		 CTD PMID:16214333 PMID:30116142 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Ulk1 unc-51 like kinase 1 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of ULK1 mRNA CTD PMID:33549593 NCBI chr 5:110,932,355...110,957,991
Ensembl chr 5:110,932,354...110,957,963 		JBrowse link
G Usp2 ubiquitin specific peptidase 2 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in increased expression of USP2 mRNA CTD PMID:33549593 NCBI chr 9:43,978,318...44,006,924
Ensembl chr 9:43,978,318...44,006,924 		JBrowse link
G Vnn1 vanin 1 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of VNN1 mRNA CTD PMID:33549593 NCBI chr10:23,770,586...23,781,242
Ensembl chr10:23,770,586...23,781,241 		JBrowse link
ferroheme b term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 increases expression ISO
EXP		 Heme results in increased expression of ABCB6 mRNA; Heme results in increased expression of ABCB6 protein CTD PMID:17006453 NCBI chr 1:75,148,284...75,157,066
Ensembl chr 1:75,148,361...75,157,036 		JBrowse link
G Adra1a adrenergic receptor, alpha 1a increases expression EXP Heme metabolite results in increased expression of ADRA1A mRNA CTD PMID:19191707 NCBI chr14:66,872,700...67,008,689
Ensembl chr14:66,872,700...67,008,617 		JBrowse link
G Alas1 aminolevulinic acid synthase 1 decreases expression
multiple interactions		 ISO Heme results in decreased expression of ALAS1 protein
MG 262 inhibits the reaction [Heme results in decreased expression of ALAS1 protein]; Protease Inhibitors inhibits the reaction [Heme results in decreased expression of ALAS1 protein]; succinylacetone inhibits the reaction [Heme results in decreased expression of ALAS1 protein]		 CTD PMID:21659532 NCBI chr 9:106,110,654...106,125,153
Ensembl chr 9:106,110,654...106,125,853 		JBrowse link
G Alas2 aminolevulinic acid synthase 2, erythroid decreases expression EXP Heme metabolite results in decreased expression of ALAS2 mRNA CTD PMID:19191707 NCBI chr  X:149,330,413...149,353,618
Ensembl chr  X:149,330,371...149,353,634 		JBrowse link
G Alb albumin affects binding
multiple interactions		 ISO Heme binds to ALB protein
abacavir inhibits the reaction [Heme binds to ALB protein]; Heme inhibits the reaction [abacavir binds to ALB protein]		 CTD PMID:16336266 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Ambp alpha 1 microglobulin/bikunin precursor increases expression ISO Heme results in increased expression of AMBP mRNA CTD PMID:22096585 NCBI chr 4:63,061,512...63,072,409
Ensembl chr 4:63,061,512...63,073,036 		JBrowse link
G App amyloid beta (A4) precursor protein affects binding
multiple interactions		 ISO APP protein modified form binds to Heme
[Hydrogen Peroxide co-treated with Sodium Nitrite] promotes the reaction [APP protein modified form binds to Heme]; Hydrogen Peroxide promotes the reaction [APP protein modified form binds to Heme]		 CTD PMID:25211009 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654 		JBrowse link
G Arhgap31 Rho GTPase activating protein 31 decreases expression EXP Heme metabolite results in decreased expression of ARHGAP31 mRNA CTD PMID:19191707 NCBI chr16:38,418,705...38,533,397
Ensembl chr16:38,418,702...38,533,636 		JBrowse link
G Asb1 ankyrin repeat and SOCS box-containing 1 increases expression EXP Heme metabolite results in increased expression of ASB1 mRNA CTD PMID:19191707 NCBI chr 1:91,467,725...91,487,312
Ensembl chr 1:91,468,266...91,487,311 		JBrowse link
G Asxl2 ASXL transcriptional regulator 2 decreases expression EXP Heme metabolite results in decreased expression of ASXL2 mRNA CTD PMID:19191707 NCBI chr12:3,476,857...3,560,811
Ensembl chr12:3,476,857...3,556,852 		JBrowse link
G Atp7b ATPase, Cu++ transporting, beta polypeptide multiple interactions ISO ATP7B gene mutant form promotes the reaction [Copper results in decreased abundance of Heme] CTD PMID:19888908 NCBI chr 8:22,482,799...22,550,632
Ensembl chr 8:22,482,801...22,550,321 		JBrowse link
G Bcar3 breast cancer anti-estrogen resistance 3 increases expression EXP Heme metabolite results in increased expression of BCAR3 mRNA CTD PMID:19191707 NCBI chr 3:122,213,406...122,323,840
Ensembl chr 3:122,087,785...122,323,840 		JBrowse link
G Blvra biliverdin reductase A increases expression EXP Heme metabolite results in increased expression of BLVRA mRNA CTD PMID:19191707 NCBI chr 2:126,912,549...126,939,004
Ensembl chr 2:126,912,585...126,939,004 		JBrowse link
G Bok BCL2-related ovarian killer decreases expression EXP Heme metabolite results in decreased expression of BOK mRNA CTD PMID:19191707 NCBI chr 1:93,613,297...93,623,492
Ensembl chr 1:93,613,382...93,623,486 		JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II, beta decreases expression EXP Heme metabolite results in decreased expression of CAMK2B mRNA CTD PMID:19191707 NCBI chr11:5,919,642...6,016,401
Ensembl chr11:5,919,644...6,016,362 		JBrowse link
G Camk2g calcium/calmodulin-dependent protein kinase II gamma decreases expression EXP Heme metabolite results in decreased expression of CAMK2G mRNA CTD PMID:19191707 NCBI chr14:20,784,941...20,844,225
Ensembl chr14:20,784,943...20,844,156 		JBrowse link
G Car1 carbonic anhydrase 1 multiple interactions
increases expression		 ISO [Heme co-treated with Calcium, Dietary] results in increased expression of CAR1 mRNA
Heme results in increased expression of CAR1 mRNA		 CTD PMID:15539406 NCBI chr 3:14,831,274...14,873,425
Ensembl chr 3:14,831,276...14,873,428 		JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 increases expression EXP Heme metabolite results in increased expression of CCL2 mRNA CTD PMID:19191707 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccl3 chemokine (C-C motif) ligand 3 increases secretion ISO Heme analog results in increased secretion of CCL3 protein CTD PMID:23355332 NCBI chr11:83,538,669...83,540,204
Ensembl chr11:83,538,670...83,540,181 		JBrowse link
G Ccl6 chemokine (C-C motif) ligand 6 increases expression EXP Heme metabolite results in increased expression of CCL6 mRNA CTD PMID:19191707 NCBI chr11:83,478,712...83,483,913
Ensembl chr11:83,478,708...83,483,913 		JBrowse link
G Ccs copper chaperone for superoxide dismutase multiple interactions EXP [Heme binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]; [Heme binds to HPX protein] which results in increased degradation of CCS protein; lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein] CTD PMID:19039664 NCBI chr19:4,875,394...4,889,384
Ensembl chr19:4,875,394...4,889,360 		JBrowse link
G Cd2 CD2 antigen increases expression EXP Heme metabolite results in increased expression of CD2 mRNA CTD PMID:19191707 NCBI chr 3:101,183,224...101,195,255
Ensembl chr 3:101,183,215...101,195,255 		JBrowse link
G Cel carboxyl ester lipase decreases expression
multiple interactions		 ISO Heme results in decreased expression of CEL mRNA
[Heme co-treated with Calcium, Dietary] results in decreased expression of CEL mRNA		 CTD PMID:15539406 NCBI chr 2:28,445,831...28,453,415
Ensembl chr 2:28,445,807...28,453,415 		JBrowse link
G Clca1 chloride channel accessory 1 decreases expression ISO Heme results in decreased expression of CLCA1 mRNA CTD PMID:15539406 NCBI chr 3:144,710,298...144,738,537
Ensembl chr 3:144,709,578...144,738,537 		JBrowse link
G Cnot9 CCR4-NOT transcription complex, subunit 9 increases expression EXP Heme metabolite results in increased expression of CNOT9 mRNA CTD PMID:19191707 NCBI chr 1:74,545,192...74,570,001
Ensembl chr 1:74,545,217...74,570,001 		JBrowse link
G Cops5 COP9 signalosome subunit 5 increases expression EXP Heme metabolite results in increased expression of COPS5 mRNA CTD PMID:19191707 NCBI chr 1:10,094,825...10,108,384
Ensembl chr 1:10,094,826...10,108,393 		JBrowse link
G Cpox coproporphyrinogen oxidase increases chemical synthesis ISO CPOX protein results in increased chemical synthesis of Heme CTD PMID:11248690 NCBI chr16:58,490,571...58,500,754
Ensembl chr16:58,490,655...58,537,999 		JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) decreases expression EXP Heme metabolite results in decreased expression of CSF2 mRNA CTD PMID:19191707 NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493 		JBrowse link
G Cxcl2 chemokine (C-X-C motif) ligand 2 increases expression EXP Heme metabolite results in increased expression of CXCL2 mRNA CTD PMID:19191707 NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797 		JBrowse link
G Cyb5a cytochrome b5 type A (microsomal) multiple interactions ISO [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]; [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine] CTD PMID:22390216 NCBI chr18:84,869,463...84,897,996
Ensembl chr18:84,856,829...84,897,996 		JBrowse link
G Dgcr8 DGCR8, microprocessor complex subunit affects binding ISO DGCR8 protein binds to Heme; DGCR8 protein mutant form binds to Heme CTD PMID:21454614 NCBI chr16:18,071,812...18,107,115
Ensembl chr16:18,071,812...18,107,110 		JBrowse link
G Dnajc7 DnaJ heat shock protein family (Hsp40) member C7 decreases expression ISO Heme results in decreased expression of DNAJC7 mRNA CTD PMID:15539406 NCBI chr11:100,473,644...100,511,025
Ensembl chr11:100,473,644...100,511,014 		JBrowse link
G Dner delta/notch-like EGF repeat containing decreases expression EXP Heme metabolite results in decreased expression of DNER mRNA CTD PMID:19191707 NCBI chr 1:84,347,560...84,673,942
Ensembl chr 1:84,347,560...84,673,942 		JBrowse link
G Dusp14 dual specificity phosphatase 14 increases expression EXP Heme metabolite results in increased expression of DUSP14 mRNA CTD PMID:19191707 NCBI chr11:83,938,859...83,960,088
Ensembl chr11:83,938,867...83,960,087 		JBrowse link
G Dusp2 dual specificity phosphatase 2 decreases expression EXP Heme metabolite results in decreased expression of DUSP2 mRNA CTD PMID:19191707 NCBI chr 2:127,178,079...127,180,297
Ensembl chr 2:127,178,079...127,180,296 		JBrowse link
G Eif2s3x eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked decreases expression EXP Heme metabolite results in decreased expression of EIF2S3X mRNA CTD PMID:19191707 NCBI chr  X:93,232,315...93,256,257
Ensembl chr  X:93,232,313...93,256,468 		JBrowse link
G Eno2 enolase 2, gamma neuronal increases expression EXP Heme metabolite results in increased expression of ENO2 mRNA CTD PMID:19191707 NCBI chr 6:124,737,016...124,746,636
Ensembl chr 6:124,737,016...124,746,636 		JBrowse link
G Ereg epiregulin increases expression EXP Heme metabolite results in increased expression of EREG mRNA CTD PMID:19191707 NCBI chr 5:91,222,476...91,241,508
Ensembl chr 5:91,222,481...91,241,505 		JBrowse link
G Esrra estrogen related receptor, alpha decreases expression EXP Heme metabolite results in decreased expression of ESRRA mRNA CTD PMID:19191707 NCBI chr19:6,888,345...6,899,416
Ensembl chr19:6,888,345...6,899,208 		JBrowse link
G F10 coagulation factor X increases expression EXP Heme metabolite results in increased expression of F10 mRNA CTD PMID:19191707 NCBI chr 8:13,087,308...13,106,676
Ensembl chr 8:13,087,308...13,106,676 		JBrowse link
G F3 coagulation factor III increases expression
multiple interactions		 ISO Heme results in increased expression of F3 mRNA
Curcumin inhibits the reaction [Heme results in increased expression of F3 mRNA]; Heme results in increased expression of and results in increased activity of F3 protein; Sulfasalazine inhibits the reaction [Heme results in increased expression of F3 mRNA]		 CTD PMID:18983524 NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697 		JBrowse link
G Fabp2 fatty acid binding protein 2, intestinal multiple interactions
increases expression		 ISO [Heme co-treated with Calcium, Dietary] results in increased expression of FABP2 mRNA
Heme results in increased expression of FABP2 mRNA		 CTD PMID:15539406 NCBI chr 3:122,688,721...122,693,155
Ensembl chr 3:122,688,721...122,693,155 		JBrowse link
G Fabp3 fatty acid binding protein 3, muscle and heart increases expression EXP Heme metabolite results in increased expression of FABP3 mRNA CTD PMID:19191707 NCBI chr 4:130,202,531...130,209,256
Ensembl chr 4:130,202,388...130,209,256 		JBrowse link
G Fos FBJ osteosarcoma oncogene decreases expression EXP Heme metabolite results in decreased expression of FOS mRNA CTD PMID:19191707 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Fxyd4 FXYD domain-containing ion transport regulator 4 decreases expression ISO Heme results in decreased expression of FXYD4 mRNA CTD PMID:15539406 NCBI chr 6:117,910,519...117,914,668
Ensembl chr 6:117,910,520...117,914,653 		JBrowse link
G Gfod1 glucose-fructose oxidoreductase domain containing 1 decreases expression EXP Heme metabolite results in decreased expression of GFOD1 mRNA CTD PMID:19191707 NCBI chr13:43,348,716...43,457,648
Ensembl chr13:43,348,721...43,457,648 		JBrowse link
G Gipc1 GIPC PDZ domain containing family, member 1 increases expression EXP Heme metabolite results in increased expression of GIPC1 mRNA CTD PMID:19191707 NCBI chr 8:84,376,037...84,391,418
Ensembl chr 8:84,379,306...84,391,323 		JBrowse link
G Gpr176 G protein-coupled receptor 176 increases expression EXP Heme metabolite results in increased expression of GPR176 mRNA CTD PMID:19191707 NCBI chr 2:118,107,577...118,205,022
Ensembl chr 2:118,107,591...118,203,900 		JBrowse link
G Gprc5a G protein-coupled receptor, family C, group 5, member A increases expression EXP Heme metabolite results in increased expression of GPRC5A mRNA CTD PMID:19191707 NCBI chr 6:135,042,660...135,061,707
Ensembl chr 6:135,042,649...135,061,707 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble increases expression EXP Heme metabolite results in increased expression of GPT mRNA CTD PMID:19191707 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Gucy1a1 guanylate cyclase 1, soluble, alpha 1 multiple interactions ISO 5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]] CTD PMID:19466990 NCBI chr 3:81,999,734...82,053,253
Ensembl chr 3:81,999,734...82,053,096 		JBrowse link
G Gucy1b1 guanylate cyclase 1, soluble, beta 1 multiple interactions ISO Polysorbates inhibits the reaction [Heme binds to GUCY1B1 protein]
5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]		 CTD PMID:19466990 PMID:22171090 NCBI chr 3:81,939,311...81,982,018
Ensembl chr 3:81,939,313...81,981,996 		JBrowse link
G H2-Ab1 histocompatibility 2, class II antigen A, beta 1 decreases expression EXP Heme metabolite results in decreased expression of H2-AB1 mRNA CTD PMID:19191707 NCBI chr17:34,482,201...34,488,392
Ensembl chr17:34,476,663...34,488,393 		JBrowse link
G H2-Q1 histocompatibility 2, Q region locus 1 decreases expression EXP Heme metabolite results in decreased expression of H2-Q1 mRNA CTD PMID:19191707 NCBI chr17:35,539,503...35,547,118
Ensembl chr17:35,539,381...35,544,075 		JBrowse link
G H2-T23 histocompatibility 2, T region locus 23 increases expression EXP Heme metabolite results in increased expression of H2-T23 mRNA CTD PMID:19191707 NCBI chr17:36,340,869...36,343,593
Ensembl chr17:36,340,665...36,343,747 		JBrowse link
G Hectd3 HECT domain E3 ubiquitin protein ligase 3 decreases expression EXP Heme metabolite results in decreased expression of HECTD3 mRNA CTD PMID:19191707 NCBI chr 4:116,852,491...116,862,474
Ensembl chr 4:116,852,514...116,862,474 		JBrowse link
G Hk3 hexokinase 3 increases expression EXP Heme metabolite results in increased expression of HK3 mRNA CTD PMID:19191707 NCBI chr13:55,153,798...55,169,233
Ensembl chr13:55,153,798...55,169,198 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases degradation
increases metabolic processing
decreases expression
decreases abundance
increases expression		 ISO
EXP		 [HMOX1 protein results in increased degradation of Heme] which results in increased abundance of Iron; NFE2L2 mutant form inhibits the reaction [Heme results in increased expression of HMOX1 mRNA]; SLC46A1 protein promotes the reaction [Heme results in increased expression of HMOX1 mRNA]
HMOX1 protein results in increased metabolism of Heme
Heme results in decreased expression of HMOX1 mRNA
HMOX1 protein results in decreased abundance of Heme
[Heme binds to HPX protein] which results in increased expression of HMOX1 protein; Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]; HMOX1 enhancer affects the reaction [Heme results in increased expression of HMOX1 mRNA]; Triethylenephosphoramide inhibits the reaction [Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]]
Heme analog results in increased expression of HMOX1 protein; Heme results in increased expression of HMOX1 mRNA; Heme results in increased expression of HMOX1 protein
Heme metabolite results in increased expression of HMOX1 mRNA; Heme results in increased expression of HMOX1 mRNA
[stannous chloride results in increased activity of HMOX1 protein] which results in decreased abundance of Heme; Heme promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of and results in increased activity of HMOX1 protein]		 CTD PMID:7538129 PMID:8630002 PMID:9224953 PMID:10874044 PMID:12783778 More... NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hpx hemopexin multiple interactions
affects binding		 EXP [Heme binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]; [Heme binds to HPX protein] which results in increased degradation of CCS protein; [Heme binds to HPX protein] which results in increased expression of HMOX1 protein; [Heme co-treated with HPX protein] affects the activity of MT1 promoter; [Heme co-treated with HPX protein] affects the localization of MTF1 protein; bathocuproine sulfonate inhibits the reaction [[Heme co-treated with HPX protein] affects the localization of MTF1 protein]; Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]; Copper inhibits the reaction [Heme binds to HPX protein]; lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein]; Triethylenephosphoramide inhibits the reaction [Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]] CTD PMID:11213479 PMID:19039664 NCBI chr 7:105,240,818...105,249,323
Ensembl chr 7:105,240,820...105,249,344 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]] CTD PMID:11076874 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Il1a interleukin 1 alpha increases expression EXP Heme metabolite results in increased expression of IL1A mRNA CTD PMID:19191707 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion		 ISO Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]]
Heme analog results in increased secretion of IL1B protein		 CTD PMID:11076874 PMID:23355332 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 decreases expression EXP Heme metabolite results in decreased expression of IL1RL1 mRNA CTD PMID:19191707 NCBI chr 1:40,444,025...40,504,578
Ensembl chr 1:40,468,730...40,504,575 		JBrowse link
G Il20 interleukin 20 increases expression EXP Heme metabolite results in increased expression of IL20 mRNA CTD PMID:19191707 NCBI chr 1:130,834,722...130,839,033
Ensembl chr 1:130,834,722...130,839,188 		JBrowse link
G Il7r interleukin 7 receptor increases expression EXP Heme metabolite results in increased expression of IL7R mRNA CTD PMID:19191707 NCBI chr15:9,505,880...9,530,270
Ensembl chr15:9,505,874...9,530,262 		JBrowse link
G Irf3 interferon regulatory factor 3 decreases expression EXP Heme metabolite results in decreased expression of IRF3 mRNA CTD PMID:19191707 NCBI chr 7:44,647,072...44,652,272
Ensembl chr 7:44,647,072...44,652,272 		JBrowse link
G Irf4 interferon regulatory factor 4 increases expression EXP Heme metabolite results in increased expression of IRF4 mRNA CTD PMID:19191707 NCBI chr13:30,933,191...30,950,965
Ensembl chr13:30,933,209...30,950,959 		JBrowse link
G Itln1 intelectin 1 (galactofuranose binding) decreases expression ISO Heme results in decreased expression of ITLN1 mRNA CTD PMID:15539406 NCBI chr 1:171,345,691...171,362,893
Ensembl chr 1:171,345,690...171,362,862 		JBrowse link
G Krt20 keratin 20 increases expression ISO Heme results in increased expression of KRT20 mRNA CTD PMID:15539406 NCBI chr11:99,319,211...99,328,979
Ensembl chr11:99,319,229...99,328,976 		JBrowse link
G Lep leptin multiple interactions
increases abundance		 EXP cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in increased abundance of Heme]; tin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in increased abundance of Heme]] CTD PMID:23839791 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Lyz2 lysozyme 2 multiple interactions
increases secretion		 ISO SB 203580 inhibits the reaction [Heme analog results in increased secretion of LYZ protein] CTD PMID:23355332 NCBI chr10:117,113,446...117,118,177
Ensembl chr10:117,113,236...117,118,226 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Heme inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:17292349 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Mptx1 mucosal pentraxin 1 decreases expression
multiple interactions		 ISO Heme results in decreased expression of MPTX1 mRNA
Calcium, Dietary inhibits the reaction [Heme results in decreased expression of MPTX1 mRNA]		 CTD PMID:15539406 NCBI chr 1:174,158,084...174,160,443
Ensembl chr 1:174,158,084...174,160,439 		JBrowse link
G Mre11a MRE11A homolog A, double strand break repair nuclease decreases expression EXP Heme metabolite results in decreased expression of MRE11A mRNA CTD PMID:19191707 NCBI chr 9:14,695,939...14,753,639
Ensembl chr 9:14,695,950...14,748,419 		JBrowse link
G Ms4a6b membrane-spanning 4-domains, subfamily A, member 6B decreases expression EXP Heme metabolite results in decreased expression of MS4A6B mRNA CTD PMID:19191707 NCBI chr19:11,495,923...11,507,767
Ensembl chr19:11,493,876...11,508,620 		JBrowse link
G Mt1 metallothionein 1 multiple interactions EXP [Heme co-treated with HPX protein] affects the activity of MT1 promoter CTD PMID:11213479 NCBI chr 8:94,905,214...94,906,955
Ensembl chr 8:94,905,710...94,906,955 		JBrowse link
G Mtf1 metal response element binding transcription factor 1 multiple interactions EXP [Heme co-treated with HPX protein] affects the localization of MTF1 protein; bathocuproine sulfonate inhibits the reaction [[Heme co-treated with HPX protein] affects the localization of MTF1 protein] CTD PMID:11213479 NCBI chr 4:124,696,342...124,743,593
Ensembl chr 4:124,695,897...124,743,593 		JBrowse link
G Mtmr10 myotubularin related protein 10 increases expression EXP Heme metabolite results in increased expression of MTMR10 mRNA CTD PMID:19191707 NCBI chr 7:63,937,418...63,990,554
Ensembl chr 7:63,937,401...63,990,554 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO NFE2L2 mutant form inhibits the reaction [Heme results in increased expression of HMOX1 mRNA] CTD PMID:10874044 NCBI chr 2:75,505,857...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 affects localization ISO Heme analog affects the localization of NFKB1 protein CTD PMID:23355332 NCBI chr 3:135,290,416...135,397,728
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO Heme analog results in increased phosphorylation of and results in increased degradation of NFKBIA protein CTD PMID:23355332 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Ngb neuroglobin affects binding EXP Carbon Dioxide binds to [Heme binds to NGB protein]; Heme binds to NGB protein CTD PMID:16684569 NCBI chr12:87,144,305...87,149,313
Ensembl chr12:87,144,305...87,149,313 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]] CTD PMID:11076874 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Olfr112 olfactory receptor 112 decreases expression EXP Heme metabolite results in decreased expression of OLFR112 mRNA CTD PMID:19191707 NCBI chr17:37,874,031...37,880,342
Ensembl chr17:37,872,559...37,880,342 		JBrowse link
G Olfr313 olfactory receptor 313 increases expression EXP Heme metabolite results in increased expression of OLFR313 mRNA CTD PMID:19191707 NCBI chr11:58,707,754...58,708,827
Ensembl chr11:58,705,826...58,710,276 		JBrowse link
G Pars2 prolyl-tRNA synthetase (mitochondrial)(putative) decreases expression EXP Heme metabolite results in decreased expression of PARS2 mRNA CTD PMID:19191707 NCBI chr 4:106,508,266...106,512,479
Ensembl chr 4:106,508,266...106,512,479 		JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 increases expression EXP Heme metabolite results in increased expression of PCSK2 mRNA CTD PMID:19191707 NCBI chr 2:143,388,053...143,658,204
Ensembl chr 2:143,388,076...143,658,205 		JBrowse link
G Pdgfb platelet derived growth factor, B polypeptide decreases expression EXP Heme metabolite results in decreased expression of PDGFB mRNA CTD PMID:19191707 NCBI chr15:79,880,066...79,899,178
Ensembl chr15:79,880,075...79,899,178 		JBrowse link
G Pgap2 post-GPI attachment to proteins 2 decreases expression EXP Heme metabolite results in decreased expression of PGAP2 mRNA CTD PMID:19191707 NCBI chr 7:101,859,153...101,887,771
Ensembl chr 7:101,859,415...101,887,774 		JBrowse link
G Phlda1 pleckstrin homology like domain, family A, member 1 decreases expression EXP Heme metabolite results in decreased expression of PHLDA1 mRNA CTD PMID:19191707 NCBI chr10:111,342,147...111,344,510
Ensembl chr10:111,342,147...111,344,506 		JBrowse link
G Pja2 praja ring finger ubiquitin ligase 2 decreases expression EXP Heme metabolite results in decreased expression of PJA2 mRNA CTD PMID:19191707 NCBI chr17:64,588,001...64,638,878
Ensembl chr17:64,588,000...64,638,911 		JBrowse link
G Plekhm1 pleckstrin homology domain containing, family M (with RUN domain) member 1 increases expression EXP Heme metabolite results in increased expression of PLEKHM1 mRNA CTD PMID:19191707 NCBI chr11:103,255,101...103,303,531
Ensembl chr11:103,255,101...103,303,513 		JBrowse link
G Plekho1 pleckstrin homology domain containing, family O member 1 increases expression EXP Heme metabolite results in increased expression of PLEKHO1 mRNA CTD PMID:19191707 NCBI chr 3:95,896,121...95,903,300
Ensembl chr 3:95,895,741...95,903,313 		JBrowse link
G Plk2 polo like kinase 2 increases expression EXP Heme metabolite results in increased expression of PLK2 mRNA CTD PMID:19191707 NCBI chr13:110,531,578...110,537,378
Ensembl chr13:110,531,580...110,537,378 		JBrowse link
G Plxna2 plexin A2 increases expression EXP Heme metabolite results in increased expression of PLXNA2 mRNA CTD PMID:19191707 NCBI chr 1:194,302,020...194,499,177
Ensembl chr 1:194,300,526...194,499,177 		JBrowse link
G Pomt1 protein-O-mannosyltransferase 1 decreases expression EXP Heme metabolite results in decreased expression of POMT1 mRNA CTD PMID:19191707 NCBI chr 2:32,126,652...32,145,017
Ensembl chr 2:32,126,602...32,145,017 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]; [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine] CTD PMID:22390216 NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180 		JBrowse link
G Ppie peptidylprolyl isomerase E (cyclophilin E) increases expression EXP Heme metabolite results in increased expression of PPIE mRNA CTD PMID:19191707 NCBI chr 4:123,020,907...123,033,783
Ensembl chr 4:123,020,908...123,033,744 		JBrowse link
G Pstpip2 proline-serine-threonine phosphatase-interacting protein 2 increases expression EXP Heme metabolite results in increased expression of PSTPIP2 mRNA CTD PMID:19191707 NCBI chr18:77,882,250...77,971,462
Ensembl chr18:77,877,614...77,970,579 		JBrowse link
G Rab33a RAB33A, member RAS oncogene family increases expression EXP Heme metabolite results in increased expression of RAB33A mRNA CTD PMID:19191707 NCBI chr  X:47,602,540...47,619,117
Ensembl chr  X:47,608,162...47,619,109 		JBrowse link
G Rab3a RAB3A, member RAS oncogene family decreases expression EXP Heme metabolite results in decreased expression of RAB3A mRNA CTD PMID:19191707 NCBI chr 8:71,207,258...71,211,276
Ensembl chr 8:71,207,328...71,211,323 		JBrowse link
G Rbm39 RNA binding motif protein 39 increases expression EXP Heme metabolite results in increased expression of RBM39 mRNA CTD PMID:19191707 NCBI chr 2:155,989,159...156,022,649
Ensembl chr 2:155,989,159...156,022,158 		JBrowse link
G Rbx1 ring-box 1 increases expression EXP Heme metabolite results in increased expression of RBX1 mRNA CTD PMID:19191707 NCBI chr15:81,350,517...81,360,570
Ensembl chr15:81,350,497...81,360,570 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) affects localization ISO Heme analog affects the localization of RELA protein CTD PMID:23355332 NCBI chr19:5,687,569...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Rhebl1 Ras homolog enriched in brain like 1 increases expression EXP Heme metabolite results in increased expression of RHEBL1 mRNA CTD PMID:19191707 NCBI chr15:98,775,641...98,779,424
Ensembl chr15:98,775,659...98,792,421 		JBrowse link
G Rpap1 RNA polymerase II associated protein 1 decreases expression EXP Heme metabolite results in decreased expression of RPAP1 mRNA CTD PMID:19191707 NCBI chr 2:119,594,440...119,618,018
Ensembl chr 2:119,593,785...119,618,018 		JBrowse link
G Rps6ka2 ribosomal protein S6 kinase, polypeptide 2 increases expression EXP Heme metabolite results in increased expression of RPS6KA2 mRNA CTD PMID:19191707 NCBI chr17:7,356,384...7,570,714
Ensembl chr17:7,437,514...7,570,714 		JBrowse link
G Setdb1 SET domain, bifurcated 1 decreases expression EXP Heme metabolite results in decreased expression of SETDB1 mRNA CTD PMID:19191707 NCBI chr 3:95,230,836...95,264,513
Ensembl chr 3:95,230,836...95,264,513 		JBrowse link
G Slamf7 SLAM family member 7 increases expression EXP Heme metabolite results in increased expression of SLAMF7 mRNA CTD PMID:19191707 NCBI chr 1:171,459,971...171,480,605
Ensembl chr 1:171,459,971...171,480,603 		JBrowse link
G Slc46a1 solute carrier family 46, member 1 multiple interactions
increases uptake		 ISO SLC46A1 protein promotes the reaction [Heme results in increased expression of HMOX1 mRNA]
SLC46A1 protein results in increased uptake of Heme		 CTD PMID:17156779 NCBI chr11:78,356,527...78,362,771
Ensembl chr11:78,356,523...78,362,885 		JBrowse link
G Smarcb1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 decreases expression EXP Heme metabolite results in decreased expression of SMARCB1 mRNA CTD PMID:19191707 NCBI chr10:75,732,603...75,757,448
Ensembl chr10:75,732,603...75,757,451 		JBrowse link
G Smc4 structural maintenance of chromosomes 4 decreases expression EXP Heme metabolite results in decreased expression of SMC4 mRNA CTD PMID:19191707 NCBI chr 3:68,912,071...68,941,956
Ensembl chr 3:68,912,071...68,941,956 		JBrowse link
G Srp9 signal recognition particle 9 increases expression EXP Heme metabolite results in increased expression of SRP9 mRNA CTD PMID:19191707 NCBI chr 1:181,952,302...181,959,980
Ensembl chr 1:181,952,302...181,959,972 		JBrowse link
G Stard4 StAR-related lipid transfer (START) domain containing 4 increases expression EXP Heme metabolite results in increased expression of STARD4 mRNA CTD PMID:19191707 NCBI chr18:33,332,191...33,346,937
Ensembl chr18:33,332,408...33,346,915 		JBrowse link
G Taf7 TATA-box binding protein associated factor 7 increases expression EXP Heme metabolite results in increased expression of TAF7 mRNA CTD PMID:19191707 NCBI chr18:37,773,544...37,777,257
Ensembl chr18:37,773,544...37,777,257 		JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase multiple interactions ISO Heme promotes the reaction [pyridine results in increased activity of TDO2 protein] CTD PMID:10413312 NCBI chr 3:81,865,719...81,883,035
Ensembl chr 3:81,864,397...81,883,509 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion		 ISO Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]]
Heme analog results in increased secretion of TNF protein		 CTD PMID:11076874 PMID:23355332 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfsf13b tumor necrosis factor (ligand) superfamily, member 13b decreases expression EXP Heme metabolite results in decreased expression of TNFSF13B mRNA CTD PMID:19191707 NCBI chr 8:10,056,229...10,086,000
Ensembl chr 8:10,056,467...10,089,072 		JBrowse link
G Tollip toll interacting protein increases expression EXP Heme metabolite results in increased expression of TOLLIP mRNA CTD PMID:19191707 NCBI chr 7:141,435,317...141,456,198
Ensembl chr 7:141,428,550...141,472,244 		JBrowse link
G Tuba4a tubulin, alpha 4A increases expression EXP Heme metabolite results in increased expression of TUBA4A mRNA CTD PMID:19191707 NCBI chr 1:75,191,616...75,197,905
Ensembl chr 1:75,190,872...75,196,509 		JBrowse link
G Ube2l3 ubiquitin-conjugating enzyme E2L 3 increases expression EXP Heme metabolite results in increased expression of UBE2L3 mRNA CTD PMID:19191707 NCBI chr16:16,969,879...17,019,376
Ensembl chr16:16,969,877...17,020,513 		JBrowse link
G Ube2r2 ubiquitin-conjugating enzyme E2R 2 decreases expression EXP Heme metabolite results in decreased expression of UBE2R2 mRNA CTD PMID:19191707 NCBI chr 4:41,136,021...41,193,370
Ensembl chr 4:41,135,743...41,193,380 		JBrowse link
G Wfikkn2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 decreases expression EXP Heme metabolite results in decreased expression of WFIKKN2 mRNA CTD PMID:19191707 NCBI chr11:94,126,777...94,138,613
Ensembl chr11:94,126,782...94,136,831 		JBrowse link
G Yeats2 YEATS domain containing 2 decreases expression EXP Heme metabolite results in decreased expression of YEATS2 mRNA CTD PMID:19191707 NCBI chr16:19,959,803...20,051,323
Ensembl chr16:19,959,813...20,051,323 		JBrowse link
glutathionylcobalamin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase multiple interactions ISO [glutathionylcobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form CTD PMID:26989453 NCBI chr13:12,196,217...12,273,090
Ensembl chr13:12,197,598...12,272,999 		JBrowse link
heme b term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 increases expression EXP
ISO		 Heme results in increased expression of ABCB6 mRNA; Heme results in increased expression of ABCB6 protein CTD PMID:17006453 NCBI chr 1:75,148,284...75,157,066
Ensembl chr 1:75,148,361...75,157,036 		JBrowse link
G Adra1a adrenergic receptor, alpha 1a increases expression EXP Heme metabolite results in increased expression of ADRA1A mRNA CTD PMID:19191707 NCBI chr14:66,872,700...67,008,689
Ensembl chr14:66,872,700...67,008,617 		JBrowse link
G Alas1 aminolevulinic acid synthase 1 multiple interactions
decreases expression		 ISO MG 262 inhibits the reaction [Heme results in decreased expression of ALAS1 protein]; Protease Inhibitors inhibits the reaction [Heme results in decreased expression of ALAS1 protein]; succinylacetone inhibits the reaction [Heme results in decreased expression of ALAS1 protein] CTD PMID:21659532 NCBI chr 9:106,110,654...106,125,153
Ensembl chr 9:106,110,654...106,125,853 		JBrowse link
G Alas2 aminolevulinic acid synthase 2, erythroid decreases expression EXP Heme metabolite results in decreased expression of ALAS2 mRNA CTD PMID:19191707 NCBI chr  X:149,330,413...149,353,618
Ensembl chr  X:149,330,371...149,353,634 		JBrowse link
G Alb albumin multiple interactions
affects binding		 ISO abacavir inhibits the reaction [Heme binds to ALB protein]; Heme inhibits the reaction [abacavir binds to ALB protein] CTD PMID:16336266 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Ambp alpha 1 microglobulin/bikunin precursor increases expression ISO Heme results in increased expression of AMBP mRNA CTD PMID:22096585 NCBI chr 4:63,061,512...63,072,409
Ensembl chr 4:63,061,512...63,073,036 		JBrowse link
G App amyloid beta (A4) precursor protein affects binding
multiple interactions		 ISO APP protein modified form binds to Heme
[Hydrogen Peroxide co-treated with Sodium Nitrite] promotes the reaction [APP protein modified form binds to Heme]; Hydrogen Peroxide promotes the reaction [APP protein modified form binds to Heme]		 CTD PMID:25211009 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654 		JBrowse link
G Arhgap31 Rho GTPase activating protein 31 decreases expression EXP Heme metabolite results in decreased expression of ARHGAP31 mRNA CTD PMID:19191707 NCBI chr16:38,418,705...38,533,397
Ensembl chr16:38,418,702...38,533,636 		JBrowse link
G Asb1 ankyrin repeat and SOCS box-containing 1 increases expression EXP Heme metabolite results in increased expression of ASB1 mRNA CTD PMID:19191707 NCBI chr 1:91,467,725...91,487,312
Ensembl chr 1:91,468,266...91,487,311 		JBrowse link
G Asxl2 ASXL transcriptional regulator 2 decreases expression EXP Heme metabolite results in decreased expression of ASXL2 mRNA CTD PMID:19191707 NCBI chr12:3,476,857...3,560,811
Ensembl chr12:3,476,857...3,556,852 		JBrowse link
G Atp7b ATPase, Cu++ transporting, beta polypeptide multiple interactions ISO ATP7B gene mutant form promotes the reaction [Copper results in decreased abundance of Heme] CTD PMID:19888908 NCBI chr 8:22,482,799...22,550,632
Ensembl chr 8:22,482,801...22,550,321 		JBrowse link
G Bcar3 breast cancer anti-estrogen resistance 3 increases expression EXP Heme metabolite results in increased expression of BCAR3 mRNA CTD PMID:19191707 NCBI chr 3:122,213,406...122,323,840
Ensembl chr 3:122,087,785...122,323,840 		JBrowse link
G Blvra biliverdin reductase A increases expression EXP Heme metabolite results in increased expression of BLVRA mRNA CTD PMID:19191707 NCBI chr 2:126,912,549...126,939,004
Ensembl chr 2:126,912,585...126,939,004 		JBrowse link
G Bok BCL2-related ovarian killer decreases expression EXP Heme metabolite results in decreased expression of BOK mRNA CTD PMID:19191707 NCBI chr 1:93,613,297...93,623,492
Ensembl chr 1:93,613,382...93,623,486 		JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II, beta decreases expression EXP Heme metabolite results in decreased expression of CAMK2B mRNA CTD PMID:19191707 NCBI chr11:5,919,642...6,016,401
Ensembl chr11:5,919,644...6,016,362 		JBrowse link
G Camk2g calcium/calmodulin-dependent protein kinase II gamma decreases expression EXP Heme metabolite results in decreased expression of CAMK2G mRNA CTD PMID:19191707 NCBI chr14:20,784,941...20,844,225
Ensembl chr14:20,784,943...20,844,156 		JBrowse link
G Car1 carbonic anhydrase 1 multiple interactions
increases expression		 ISO [Heme co-treated with Calcium, Dietary] results in increased expression of CAR1 mRNA
Heme results in increased expression of CAR1 mRNA		 CTD PMID:15539406 NCBI chr 3:14,831,274...14,873,425
Ensembl chr 3:14,831,276...14,873,428 		JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 increases expression EXP Heme metabolite results in increased expression of CCL2 mRNA CTD PMID:19191707 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccl3 chemokine (C-C motif) ligand 3 increases secretion ISO Heme analog results in increased secretion of CCL3 protein CTD PMID:23355332 NCBI chr11:83,538,669...83,540,204
Ensembl chr11:83,538,670...83,540,181 		JBrowse link
G Ccl6 chemokine (C-C motif) ligand 6 increases expression EXP Heme metabolite results in increased expression of CCL6 mRNA CTD PMID:19191707 NCBI chr11:83,478,712...83,483,913
Ensembl chr11:83,478,708...83,483,913 		JBrowse link
G Ccs copper chaperone for superoxide dismutase multiple interactions EXP [Heme binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]; [Heme binds to HPX protein] which results in increased degradation of CCS protein; lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein] CTD PMID:19039664 NCBI chr19:4,875,394...4,889,384
Ensembl chr19:4,875,394...4,889,360 		JBrowse link
G Cd2 CD2 antigen increases expression EXP Heme metabolite results in increased expression of CD2 mRNA CTD PMID:19191707 NCBI chr 3:101,183,224...101,195,255
Ensembl chr 3:101,183,215...101,195,255 		JBrowse link
G Cel carboxyl ester lipase decreases expression
multiple interactions		 ISO Heme results in decreased expression of CEL mRNA
[Heme co-treated with Calcium, Dietary] results in decreased expression of CEL mRNA		 CTD PMID:15539406 NCBI chr 2:28,445,831...28,453,415
Ensembl chr 2:28,445,807...28,453,415 		JBrowse link
G Clca1 chloride channel accessory 1 decreases expression ISO Heme results in decreased expression of CLCA1 mRNA CTD PMID:15539406 NCBI chr 3:144,710,298...144,738,537
Ensembl chr 3:144,709,578...144,738,537 		JBrowse link
G Cnot9 CCR4-NOT transcription complex, subunit 9 increases expression EXP Heme metabolite results in increased expression of CNOT9 mRNA CTD PMID:19191707 NCBI chr 1:74,545,192...74,570,001
Ensembl chr 1:74,545,217...74,570,001 		JBrowse link
G Cops5 COP9 signalosome subunit 5 increases expression EXP Heme metabolite results in increased expression of COPS5 mRNA CTD PMID:19191707 NCBI chr 1:10,094,825...10,108,384
Ensembl chr 1:10,094,826...10,108,393 		JBrowse link
G Cpox coproporphyrinogen oxidase increases chemical synthesis ISO CPOX protein results in increased chemical synthesis of Heme CTD PMID:11248690 NCBI chr16:58,490,571...58,500,754
Ensembl chr16:58,490,655...58,537,999 		JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) decreases expression EXP Heme metabolite results in decreased expression of CSF2 mRNA CTD PMID:19191707 NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493 		JBrowse link
G Cxcl2 chemokine (C-X-C motif) ligand 2 increases expression EXP Heme metabolite results in increased expression of CXCL2 mRNA CTD PMID:19191707 NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797 		JBrowse link
G Cyb5a cytochrome b5 type A (microsomal) multiple interactions ISO [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]; [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine] CTD PMID:22390216 NCBI chr18:84,869,463...84,897,996
Ensembl chr18:84,856,829...84,897,996 		JBrowse link
G Dgcr8 DGCR8, microprocessor complex subunit affects binding ISO DGCR8 protein binds to Heme; DGCR8 protein mutant form binds to Heme CTD PMID:21454614 NCBI chr16:18,071,812...18,107,115
Ensembl chr16:18,071,812...18,107,110 		JBrowse link
G Dnajc7 DnaJ heat shock protein family (Hsp40) member C7 decreases expression ISO Heme results in decreased expression of DNAJC7 mRNA CTD PMID:15539406 NCBI chr11:100,473,644...100,511,025
Ensembl chr11:100,473,644...100,511,014 		JBrowse link
G Dner delta/notch-like EGF repeat containing decreases expression EXP Heme metabolite results in decreased expression of DNER mRNA CTD PMID:19191707 NCBI chr 1:84,347,560...84,673,942
Ensembl chr 1:84,347,560...84,673,942 		JBrowse link
G Dusp14 dual specificity phosphatase 14 increases expression EXP Heme metabolite results in increased expression of DUSP14 mRNA CTD PMID:19191707 NCBI chr11:83,938,859...83,960,088
Ensembl chr11:83,938,867...83,960,087 		JBrowse link
G Dusp2 dual specificity phosphatase 2 decreases expression EXP Heme metabolite results in decreased expression of DUSP2 mRNA CTD PMID:19191707 NCBI chr 2:127,178,079...127,180,297
Ensembl chr 2:127,178,079...127,180,296 		JBrowse link
G Eif2s3x eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked decreases expression EXP Heme metabolite results in decreased expression of EIF2S3X mRNA CTD PMID:19191707 NCBI chr  X:93,232,315...93,256,257
Ensembl chr  X:93,232,313...93,256,468 		JBrowse link
G Eno2 enolase 2, gamma neuronal increases expression EXP Heme metabolite results in increased expression of ENO2 mRNA CTD PMID:19191707 NCBI chr 6:124,737,016...124,746,636
Ensembl chr 6:124,737,016...124,746,636 		JBrowse link
G Ereg epiregulin increases expression EXP Heme metabolite results in increased expression of EREG mRNA CTD PMID:19191707 NCBI chr 5:91,222,476...91,241,508
Ensembl chr 5:91,222,481...91,241,505 		JBrowse link
G Esrra estrogen related receptor, alpha decreases expression EXP Heme metabolite results in decreased expression of ESRRA mRNA CTD PMID:19191707 NCBI chr19:6,888,345...6,899,416
Ensembl chr19:6,888,345...6,899,208 		JBrowse link
G F10 coagulation factor X increases expression EXP Heme metabolite results in increased expression of F10 mRNA CTD PMID:19191707 NCBI chr 8:13,087,308...13,106,676
Ensembl chr 8:13,087,308...13,106,676 		JBrowse link
G F3 coagulation factor III multiple interactions
increases expression		 ISO Curcumin inhibits the reaction [Heme results in increased expression of F3 mRNA]; Heme results in increased expression of and results in increased activity of F3 protein; Sulfasalazine inhibits the reaction [Heme results in increased expression of F3 mRNA] CTD PMID:18983524 NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697 		JBrowse link
G Fabp2 fatty acid binding protein 2, intestinal increases expression
multiple interactions		 ISO Heme results in increased expression of FABP2 mRNA
[Heme co-treated with Calcium, Dietary] results in increased expression of FABP2 mRNA		 CTD PMID:15539406 NCBI chr 3:122,688,721...122,693,155
Ensembl chr 3:122,688,721...122,693,155 		JBrowse link
G Fabp3 fatty acid binding protein 3, muscle and heart increases expression EXP Heme metabolite results in increased expression of FABP3 mRNA CTD PMID:19191707 NCBI chr 4:130,202,531...130,209,256
Ensembl chr 4:130,202,388...130,209,256 		JBrowse link
G Fos FBJ osteosarcoma oncogene decreases expression EXP Heme metabolite results in decreased expression of FOS mRNA CTD PMID:19191707 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Fxyd4 FXYD domain-containing ion transport regulator 4 decreases expression ISO Heme results in decreased expression of FXYD4 mRNA CTD PMID:15539406 NCBI chr 6:117,910,519...117,914,668
Ensembl chr 6:117,910,520...117,914,653 		JBrowse link
G Gfod1 glucose-fructose oxidoreductase domain containing 1 decreases expression EXP Heme metabolite results in decreased expression of GFOD1 mRNA CTD PMID:19191707 NCBI chr13:43,348,716...43,457,648
Ensembl chr13:43,348,721...43,457,648 		JBrowse link
G Gipc1 GIPC PDZ domain containing family, member 1 increases expression EXP Heme metabolite results in increased expression of GIPC1 mRNA CTD PMID:19191707 NCBI chr 8:84,376,037...84,391,418
Ensembl chr 8:84,379,306...84,391,323 		JBrowse link
G Gpr176 G protein-coupled receptor 176 increases expression EXP Heme metabolite results in increased expression of GPR176 mRNA CTD PMID:19191707 NCBI chr 2:118,107,577...118,205,022
Ensembl chr 2:118,107,591...118,203,900 		JBrowse link
G Gprc5a G protein-coupled receptor, family C, group 5, member A increases expression EXP Heme metabolite results in increased expression of GPRC5A mRNA CTD PMID:19191707 NCBI chr 6:135,042,660...135,061,707
Ensembl chr 6:135,042,649...135,061,707 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble increases expression EXP Heme metabolite results in increased expression of GPT mRNA CTD PMID:19191707 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Gucy1a1 guanylate cyclase 1, soluble, alpha 1 multiple interactions ISO 5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]] CTD PMID:19466990 NCBI chr 3:81,999,734...82,053,253
Ensembl chr 3:81,999,734...82,053,096 		JBrowse link
G Gucy1b1 guanylate cyclase 1, soluble, beta 1 multiple interactions ISO Polysorbates inhibits the reaction [Heme binds to GUCY1B1 protein]
5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]		 CTD PMID:19466990 PMID:22171090 NCBI chr 3:81,939,311...81,982,018
Ensembl chr 3:81,939,313...81,981,996 		JBrowse link
G H2-Ab1 histocompatibility 2, class II antigen A, beta 1 decreases expression EXP Heme metabolite results in decreased expression of H2-AB1 mRNA CTD PMID:19191707 NCBI chr17:34,482,201...34,488,392
Ensembl chr17:34,476,663...34,488,393 		JBrowse link
G H2-Q1 histocompatibility 2, Q region locus 1 decreases expression EXP Heme metabolite results in decreased expression of H2-Q1 mRNA CTD PMID:19191707 NCBI chr17:35,539,503...35,547,118
Ensembl chr17:35,539,381...35,544,075 		JBrowse link
G H2-T23 histocompatibility 2, T region locus 23 increases expression EXP Heme metabolite results in increased expression of H2-T23 mRNA CTD PMID:19191707 NCBI chr17:36,340,869...36,343,593
Ensembl chr17:36,340,665...36,343,747 		JBrowse link
G Hectd3 HECT domain E3 ubiquitin protein ligase 3 decreases expression EXP Heme metabolite results in decreased expression of HECTD3 mRNA CTD PMID:19191707 NCBI chr 4:116,852,491...116,862,474
Ensembl chr 4:116,852,514...116,862,474 		JBrowse link
G Hk3 hexokinase 3 increases expression EXP Heme metabolite results in increased expression of HK3 mRNA CTD PMID:19191707 NCBI chr13:55,153,798...55,169,233
Ensembl chr13:55,153,798...55,169,198 		JBrowse link
G Hmox1 heme oxygenase 1 decreases expression
multiple interactions
increases degradation
decreases abundance
increases metabolic processing
increases expression		 ISO
EXP		 Heme results in decreased expression of HMOX1 mRNA
[stannous chloride results in increased activity of HMOX1 protein] which results in decreased abundance of Heme; Heme promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of and results in increased activity of HMOX1 protein]
HMOX1 protein results in increased degradation of Heme
HMOX1 protein results in decreased abundance of Heme
HMOX1 protein results in increased metabolism of Heme
[HMOX1 protein results in increased degradation of Heme] which results in increased abundance of Iron; NFE2L2 mutant form inhibits the reaction [Heme results in increased expression of HMOX1 mRNA]; SLC46A1 protein promotes the reaction [Heme results in increased expression of HMOX1 mRNA]
[Heme binds to HPX protein] which results in increased expression of HMOX1 protein; Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]; HMOX1 enhancer affects the reaction [Heme results in increased expression of HMOX1 mRNA]; Triethylenephosphoramide inhibits the reaction [Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]]
Heme metabolite results in increased expression of HMOX1 mRNA; Heme results in increased expression of HMOX1 mRNA
Heme analog results in increased expression of HMOX1 protein; Heme results in increased expression of HMOX1 mRNA; Heme results in increased expression of HMOX1 protein		 CTD PMID:7538129 PMID:8630002 PMID:9224953 PMID:10874044 PMID:12783778 More... NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hpx hemopexin multiple interactions
affects binding		 EXP [Heme binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]; [Heme binds to HPX protein] which results in increased degradation of CCS protein; [Heme binds to HPX protein] which results in increased expression of HMOX1 protein; [Heme co-treated with HPX protein] affects the activity of MT1 promoter; [Heme co-treated with HPX protein] affects the localization of MTF1 protein; bathocuproine sulfonate inhibits the reaction [[Heme co-treated with HPX protein] affects the localization of MTF1 protein]; Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]; Copper inhibits the reaction [Heme binds to HPX protein]; lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein]; Triethylenephosphoramide inhibits the reaction [Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]] CTD PMID:11213479 PMID:19039664 NCBI chr 7:105,240,818...105,249,323
Ensembl chr 7:105,240,820...105,249,344 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]] CTD PMID:11076874 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Il1a interleukin 1 alpha increases expression EXP Heme metabolite results in increased expression of IL1A mRNA CTD PMID:19191707 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion		 ISO Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]]
Heme analog results in increased secretion of IL1B protein		 CTD PMID:11076874 PMID:23355332 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 decreases expression EXP Heme metabolite results in decreased expression of IL1RL1 mRNA CTD PMID:19191707 NCBI chr 1:40,444,025...40,504,578
Ensembl chr 1:40,468,730...40,504,575 		JBrowse link
G Il20 interleukin 20 increases expression EXP Heme metabolite results in increased expression of IL20 mRNA CTD PMID:19191707 NCBI chr 1:130,834,722...130,839,033
Ensembl chr 1:130,834,722...130,839,188 		JBrowse link
G Il7r interleukin 7 receptor increases expression EXP Heme metabolite results in increased expression of IL7R mRNA CTD PMID:19191707 NCBI chr15:9,505,880...9,530,270
Ensembl chr15:9,505,874...9,530,262 		JBrowse link
G Irf3 interferon regulatory factor 3 decreases expression EXP Heme metabolite results in decreased expression of IRF3 mRNA CTD PMID:19191707 NCBI chr 7:44,647,072...44,652,272
Ensembl chr 7:44,647,072...44,652,272 		JBrowse link
G Irf4 interferon regulatory factor 4 increases expression EXP Heme metabolite results in increased expression of IRF4 mRNA CTD PMID:19191707 NCBI chr13:30,933,191...30,950,965
Ensembl chr13:30,933,209...30,950,959 		JBrowse link
G Itln1 intelectin 1 (galactofuranose binding) decreases expression ISO Heme results in decreased expression of ITLN1 mRNA CTD PMID:15539406 NCBI chr 1:171,345,691...171,362,893
Ensembl chr 1:171,345,690...171,362,862 		JBrowse link
G Krt20 keratin 20 increases expression ISO Heme results in increased expression of KRT20 mRNA CTD PMID:15539406 NCBI chr11:99,319,211...99,328,979
Ensembl chr11:99,319,229...99,328,976 		JBrowse link
G Lep leptin multiple interactions
increases abundance		 EXP cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in increased abundance of Heme]; tin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in increased abundance of Heme]] CTD PMID:23839791 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Lyz2 lysozyme 2 multiple interactions
increases secretion		 ISO SB 203580 inhibits the reaction [Heme analog results in increased secretion of LYZ protein] CTD PMID:23355332 NCBI chr10:117,113,446...117,118,177
Ensembl chr10:117,113,236...117,118,226 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Heme inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:17292349 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Mptx1 mucosal pentraxin 1 decreases expression
multiple interactions		 ISO Heme results in decreased expression of MPTX1 mRNA
Calcium, Dietary inhibits the reaction [Heme results in decreased expression of MPTX1 mRNA]		 CTD PMID:15539406 NCBI chr 1:174,158,084...174,160,443
Ensembl chr 1:174,158,084...174,160,439 		JBrowse link
G Mre11a MRE11A homolog A, double strand break repair nuclease decreases expression EXP Heme metabolite results in decreased expression of MRE11A mRNA CTD PMID:19191707 NCBI chr 9:14,695,939...14,753,639
Ensembl chr 9:14,695,950...14,748,419 		JBrowse link
G Ms4a6b membrane-spanning 4-domains, subfamily A, member 6B decreases expression EXP Heme metabolite results in decreased expression of MS4A6B mRNA CTD PMID:19191707 NCBI chr19:11,495,923...11,507,767
Ensembl chr19:11,493,876...11,508,620 		JBrowse link
G Mt1 metallothionein 1 multiple interactions EXP [Heme co-treated with HPX protein] affects the activity of MT1 promoter CTD PMID:11213479 NCBI chr 8:94,905,214...94,906,955
Ensembl chr 8:94,905,710...94,906,955 		JBrowse link
G Mtf1 metal response element binding transcription factor 1 multiple interactions EXP [Heme co-treated with HPX protein] affects the localization of MTF1 protein; bathocuproine sulfonate inhibits the reaction [[Heme co-treated with HPX protein] affects the localization of MTF1 protein] CTD PMID:11213479 NCBI chr 4:124,696,342...124,743,593
Ensembl chr 4:124,695,897...124,743,593 		JBrowse link
G Mtmr10 myotubularin related protein 10 increases expression EXP Heme metabolite results in increased expression of MTMR10 mRNA CTD PMID:19191707 NCBI chr 7:63,937,418...63,990,554
Ensembl chr 7:63,937,401...63,990,554 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO NFE2L2 mutant form inhibits the reaction [Heme results in increased expression of HMOX1 mRNA] CTD PMID:10874044 NCBI chr 2:75,505,857...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 affects localization ISO Heme analog affects the localization of NFKB1 protein CTD PMID:23355332 NCBI chr 3:135,290,416...135,397,728
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO Heme analog results in increased phosphorylation of and results in increased degradation of NFKBIA protein CTD PMID:23355332 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Ngb neuroglobin affects binding EXP Carbon Dioxide binds to [Heme binds to NGB protein]; Heme binds to NGB protein CTD PMID:16684569 NCBI chr12:87,144,305...87,149,313
Ensembl chr12:87,144,305...87,149,313 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]] CTD PMID:11076874 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Olfr112 olfactory receptor 112 decreases expression EXP Heme metabolite results in decreased expression of OLFR112 mRNA CTD PMID:19191707 NCBI chr17:37,874,031...37,880,342
Ensembl chr17:37,872,559...37,880,342 		JBrowse link
G Olfr313 olfactory receptor 313 increases expression EXP Heme metabolite results in increased expression of OLFR313 mRNA CTD PMID:19191707 NCBI chr11:58,707,754...58,708,827
Ensembl chr11:58,705,826...58,710,276 		JBrowse link
G Pars2 prolyl-tRNA synthetase (mitochondrial)(putative) decreases expression EXP Heme metabolite results in decreased expression of PARS2 mRNA CTD PMID:19191707 NCBI chr 4:106,508,266...106,512,479
Ensembl chr 4:106,508,266...106,512,479 		JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 increases expression EXP Heme metabolite results in increased expression of PCSK2 mRNA CTD PMID:19191707 NCBI chr 2:143,388,053...143,658,204
Ensembl chr 2:143,388,076...143,658,205 		JBrowse link
G Pdgfb platelet derived growth factor, B polypeptide decreases expression EXP Heme metabolite results in decreased expression of PDGFB mRNA CTD PMID:19191707 NCBI chr15:79,880,066...79,899,178
Ensembl chr15:79,880,075...79,899,178 		JBrowse link
G Pgap2 post-GPI attachment to proteins 2 decreases expression EXP Heme metabolite results in decreased expression of PGAP2 mRNA CTD PMID:19191707 NCBI chr 7:101,859,153...101,887,771
Ensembl chr 7:101,859,415...101,887,774 		JBrowse link
G Phlda1 pleckstrin homology like domain, family A, member 1 decreases expression EXP Heme metabolite results in decreased expression of PHLDA1 mRNA CTD PMID:19191707 NCBI chr10:111,342,147...111,344,510
Ensembl chr10:111,342,147...111,344,506 		JBrowse link
G Pja2 praja ring finger ubiquitin ligase 2 decreases expression EXP Heme metabolite results in decreased expression of PJA2 mRNA CTD PMID:19191707 NCBI chr17:64,588,001...64,638,878
Ensembl chr17:64,588,000...64,638,911 		JBrowse link
G Plekhm1 pleckstrin homology domain containing, family M (with RUN domain) member 1 increases expression EXP Heme metabolite results in increased expression of PLEKHM1 mRNA CTD PMID:19191707 NCBI chr11:103,255,101...103,303,531
Ensembl chr11:103,255,101...103,303,513 		JBrowse link
G Plekho1 pleckstrin homology domain containing, family O member 1 increases expression EXP Heme metabolite results in increased expression of PLEKHO1 mRNA CTD PMID:19191707 NCBI chr 3:95,896,121...95,903,300
Ensembl chr 3:95,895,741...95,903,313 		JBrowse link
G Plk2 polo like kinase 2 increases expression EXP Heme metabolite results in increased expression of PLK2 mRNA CTD PMID:19191707 NCBI chr13:110,531,578...110,537,378
Ensembl chr13:110,531,580...110,537,378 		JBrowse link
G Plxna2 plexin A2 increases expression EXP Heme metabolite results in increased expression of PLXNA2 mRNA CTD PMID:19191707 NCBI chr 1:194,302,020...194,499,177
Ensembl chr 1:194,300,526...194,499,177 		JBrowse link
G Pomt1 protein-O-mannosyltransferase 1 decreases expression EXP Heme metabolite results in decreased expression of POMT1 mRNA CTD PMID:19191707 NCBI chr 2:32,126,652...32,145,017
Ensembl chr 2:32,126,602...32,145,017 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]; [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine] CTD PMID:22390216 NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180 		JBrowse link
G Ppie peptidylprolyl isomerase E (cyclophilin E) increases expression EXP Heme metabolite results in increased expression of PPIE mRNA CTD PMID:19191707 NCBI chr 4:123,020,907...123,033,783
Ensembl chr 4:123,020,908...123,033,744 		JBrowse link
G Pstpip2 proline-serine-threonine phosphatase-interacting protein 2 increases expression EXP Heme metabolite results in increased expression of PSTPIP2 mRNA CTD PMID:19191707 NCBI chr18:77,882,250...77,971,462
Ensembl chr18:77,877,614...77,970,579 		JBrowse link
G Rab33a RAB33A, member RAS oncogene family increases expression EXP Heme metabolite results in increased expression of RAB33A mRNA CTD PMID:19191707 NCBI chr  X:47,602,540...47,619,117
Ensembl chr  X:47,608,162...47,619,109 		JBrowse link
G Rab3a RAB3A, member RAS oncogene family decreases expression EXP Heme metabolite results in decreased expression of RAB3A mRNA CTD PMID:19191707 NCBI chr 8:71,207,258...71,211,276
Ensembl chr 8:71,207,328...71,211,323 		JBrowse link
G Rbm39 RNA binding motif protein 39 increases expression EXP Heme metabolite results in increased expression of RBM39 mRNA CTD PMID:19191707 NCBI chr 2:155,989,159...156,022,649
Ensembl chr 2:155,989,159...156,022,158 		JBrowse link
G Rbx1 ring-box 1 increases expression EXP Heme metabolite results in increased expression of RBX1 mRNA CTD PMID:19191707 NCBI chr15:81,350,517...81,360,570
Ensembl chr15:81,350,497...81,360,570 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) affects localization ISO Heme analog affects the localization of RELA protein CTD PMID:23355332 NCBI chr19:5,687,569...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Rhebl1 Ras homolog enriched in brain like 1 increases expression EXP Heme metabolite results in increased expression of RHEBL1 mRNA CTD PMID:19191707 NCBI chr15:98,775,641...98,779,424
Ensembl chr15:98,775,659...98,792,421 		JBrowse link
G Rpap1 RNA polymerase II associated protein 1 decreases expression EXP Heme metabolite results in decreased expression of RPAP1 mRNA CTD PMID:19191707 NCBI chr 2:119,594,440...119,618,018
Ensembl chr 2:119,593,785...119,618,018 		JBrowse link
G Rps6ka2 ribosomal protein S6 kinase, polypeptide 2 increases expression EXP Heme metabolite results in increased expression of RPS6KA2 mRNA CTD PMID:19191707 NCBI chr17:7,356,384...7,570,714
Ensembl chr17:7,437,514...7,570,714 		JBrowse link
G Setdb1 SET domain, bifurcated 1 decreases expression EXP Heme metabolite results in decreased expression of SETDB1 mRNA CTD PMID:19191707 NCBI chr 3:95,230,836...95,264,513
Ensembl chr 3:95,230,836...95,264,513 		JBrowse link
G Slamf7 SLAM family member 7 increases expression EXP Heme metabolite results in increased expression of SLAMF7 mRNA CTD PMID:19191707 NCBI chr 1:171,459,971...171,480,605
Ensembl chr 1:171,459,971...171,480,603 		JBrowse link
G Slc46a1 solute carrier family 46, member 1 multiple interactions
increases uptake		 ISO SLC46A1 protein promotes the reaction [Heme results in increased expression of HMOX1 mRNA]
SLC46A1 protein results in increased uptake of Heme		 CTD PMID:17156779 NCBI chr11:78,356,527...78,362,771
Ensembl chr11:78,356,523...78,362,885 		JBrowse link
G Smarcb1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 decreases expression EXP Heme metabolite results in decreased expression of SMARCB1 mRNA CTD PMID:19191707 NCBI chr10:75,732,603...75,757,448
Ensembl chr10:75,732,603...75,757,451 		JBrowse link
G Smc4 structural maintenance of chromosomes 4 decreases expression EXP Heme metabolite results in decreased expression of SMC4 mRNA CTD PMID:19191707 NCBI chr 3:68,912,071...68,941,956
Ensembl chr 3:68,912,071...68,941,956 		JBrowse link
G Srp9 signal recognition particle 9 increases expression EXP Heme metabolite results in increased expression of SRP9 mRNA CTD PMID:19191707 NCBI chr 1:181,952,302...181,959,980
Ensembl chr 1:181,952,302...181,959,972 		JBrowse link
G Stard4 StAR-related lipid transfer (START) domain containing 4 increases expression EXP Heme metabolite results in increased expression of STARD4 mRNA CTD PMID:19191707 NCBI chr18:33,332,191...33,346,937
Ensembl chr18:33,332,408...33,346,915 		JBrowse link
G Taf7 TATA-box binding protein associated factor 7 increases expression EXP Heme metabolite results in increased expression of TAF7 mRNA CTD PMID:19191707 NCBI chr18:37,773,544...37,777,257
Ensembl chr18:37,773,544...37,777,257 		JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase multiple interactions ISO Heme promotes the reaction [pyridine results in increased activity of TDO2 protein] CTD PMID:10413312 NCBI chr 3:81,865,719...81,883,035
Ensembl chr 3:81,864,397...81,883,509 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion		 ISO Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]]
Heme analog results in increased secretion of TNF protein		 CTD PMID:11076874 PMID:23355332 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfsf13b tumor necrosis factor (ligand) superfamily, member 13b decreases expression EXP Heme metabolite results in decreased expression of TNFSF13B mRNA CTD PMID:19191707 NCBI chr 8:10,056,229...10,086,000
Ensembl chr 8:10,056,467...10,089,072 		JBrowse link
G Tollip toll interacting protein increases expression EXP Heme metabolite results in increased expression of TOLLIP mRNA CTD PMID:19191707 NCBI chr 7:141,435,317...141,456,198
Ensembl chr 7:141,428,550...141,472,244 		JBrowse link
G Tuba4a tubulin, alpha 4A increases expression EXP Heme metabolite results in increased expression of TUBA4A mRNA CTD PMID:19191707 NCBI chr 1:75,191,616...75,197,905
Ensembl chr 1:75,190,872...75,196,509 		JBrowse link
G Ube2l3 ubiquitin-conjugating enzyme E2L 3 increases expression EXP Heme metabolite results in increased expression of UBE2L3 mRNA CTD PMID:19191707 NCBI chr16:16,969,879...17,019,376
Ensembl chr16:16,969,877...17,020,513 		JBrowse link
G Ube2r2 ubiquitin-conjugating enzyme E2R 2 decreases expression EXP Heme metabolite results in decreased expression of UBE2R2 mRNA CTD PMID:19191707 NCBI chr 4:41,136,021...41,193,370
Ensembl chr 4:41,135,743...41,193,380 		JBrowse link
G Wfikkn2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 decreases expression EXP Heme metabolite results in decreased expression of WFIKKN2 mRNA CTD PMID:19191707 NCBI chr11:94,126,777...94,138,613
Ensembl chr11:94,126,782...94,136,831 		JBrowse link
G Yeats2 YEATS domain containing 2 decreases expression EXP Heme metabolite results in decreased expression of YEATS2 mRNA CTD PMID:19191707 NCBI chr16:19,959,803...20,051,323
Ensembl chr16:19,959,813...20,051,323 		JBrowse link
hemin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aco1 aconitase 1 decreases activity ISO Hemin results in decreased activity of ACO1 protein CTD PMID:16568477 NCBI chr 4:40,143,265...40,199,009
Ensembl chr 4:40,143,081...40,198,338 		JBrowse link
G Aco2 aconitase 2, mitochondrial increases expression ISO Hemin results in increased expression of ACO2 protein CTD PMID:16568477 NCBI chr15:81,756,664...81,799,338
Ensembl chr15:81,756,510...81,799,334 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases secretion ISO Hemin results in increased secretion of ADIPOQ protein CTD PMID:20016031 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO Hemin inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein] CTD PMID:18215737 NCBI chr12:112,620,255...112,641,318
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Alas2 aminolevulinic acid synthase 2, erythroid increases expression
multiple interactions		 ISO Hemin results in increased expression of ALAS2 mRNA
[catechol co-treated with Hemin] results in increased expression of ALAS2 mRNA; [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA; [S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA]; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA]; catechol promotes the reaction [Hemin results in increased expression of ALAS2 mRNA]; COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of ALAS2 mRNA]; Hemin promotes the reaction [catechol results in increased expression of ALAS2 mRNA]; Phenol inhibits the reaction [Hemin results in increased expression of ALAS2 mRNA]		 CTD PMID:23973255 PMID:24141029 PMID:28552822 NCBI chr  X:149,330,413...149,353,618
Ensembl chr  X:149,330,371...149,353,634 		JBrowse link
G Alb albumin affects binding ISO Hemin binds to ALB protein CTD PMID:10506189 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2, mitochondrial multiple interactions ISO Hemin inhibits the reaction [Nitroglycerin results in decreased activity of ALDH2 protein] CTD PMID:17541025 NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887 		JBrowse link
G Arl6ip5 ADP-ribosylation factor-like 6 interacting protein 5 increases expression ISO Hemin results in increased expression of ARL6IP5 protein CTD PMID:16430862 NCBI chr 6:97,187,753...97,210,276
Ensembl chr 6:97,187,650...97,210,276 		JBrowse link
G Bach1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 multiple interactions
increases expression
affects localization		 ISO [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] affects the localization of BACH1 protein; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of BACH1 protein; [Hemin co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased expression of BACH1 mRNA; BACH1 protein affects the reaction [Hemin results in increased expression of HMOX1 mRNA]; Hemin results in decreased localization of and results in decreased activity of BACH1 protein
Hemin results in increased expression of BACH1 mRNA; Hemin results in increased expression of BACH1 protein
Hemin affects the localization of BACH1 protein		 CTD PMID:18550526 PMID:31518892 PMID:33434570 NCBI chr16:87,495,842...87,530,234
Ensembl chr16:87,495,833...87,530,234 		JBrowse link
G Bax BCL2-associated X protein multiple interactions
increases expression		 ISO Hemin promotes the reaction [Cisplatin results in increased expression of BAX protein]
Hemin results in increased expression of BAX protein		 CTD PMID:27815112 NCBI chr 7:45,111,119...45,116,344
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO Hemin results in decreased expression of BCL2 protein CTD PMID:27815112 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 increases expression ISO Hemin results in increased expression of BIRC2 protein CTD PMID:14647439 NCBI chr 9:7,818,227...7,837,123
Ensembl chr 9:7,818,228...7,837,065 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage		 ISO
EXP		 [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with Hemin] results in increased cleavage of CASP3 protein; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased cleavage of CASP3 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased cleavage of CASP3 protein]; Hemin inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]; Hemin inhibits the reaction [Carbon Monoxide results in increased cleavage of and results in increased activity of CASP3 protein]; Hemin inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP3 protein]; Hemin inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; tin protoporphyrin IX inhibits the reaction [Hemin inhibits the reaction [Carbon Monoxide results in increased cleavage of and results in increased activity of CASP3 protein]]
[SESN2 protein affects the susceptibility to Hemin] which results in decreased expression of CASP3 protein modified form
Hemin results in increased cleavage of CASP3 protein
Hemin promotes the reaction [Cisplatin results in increased cleavage of CASP3 protein]		 CTD PMID:17173083 PMID:18845130 PMID:19150641 PMID:19520142 PMID:26747958 More... NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Cat catalase multiple interactions ISO
EXP		 Hemin inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]
Hemin inhibits the reaction [Cisplatin results in decreased activity of CAT protein]		 CTD PMID:19150641 PMID:27815112 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO [Hemin co-treated with indole-3-carbinol co-treated with 1,2-Dimethylhydrazine] affects the expression of CDH1 mRNA CTD PMID:29269057 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) increases expression
multiple interactions		 ISO Hemin results in increased expression of CDKN1A protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hemin results in increased expression of CDKN1A protein]; SB 203580 inhibits the reaction [Hemin results in increased expression of CDKN1A protein]		 CTD PMID:14647439 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases degradation ISO Hemin results in decreased degradation of CDKN1B protein CTD PMID:17283133 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476 		JBrowse link
G Cebpa CCAAT/enhancer binding protein (C/EBP), alpha increases expression
multiple interactions		 EXP Hemin results in increased expression of CEBPA mRNA
HAMP mRNA promotes the reaction [Hemin results in increased expression of CEBPA mRNA]		 CTD PMID:29749404 NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353 		JBrowse link
G Chd4 chromodomain helicase DNA binding protein 4 multiple interactions ISO [Hemin co-treated with hexamethylene bisacetamide] inhibits the reaction [CHD4 protein binds to OGT protein]; [Hemin co-treated with hexamethylene bisacetamide] inhibits the reaction [thiamet G results in increased O-linked glycosylation of CHD4 protein]; [Hemin co-treated with hexamethylene bisacetamide] results in decreased O-linked glycosylation of CHD4 protein CTD PMID:27231347 NCBI chr 6:125,072,943...125,107,554
Ensembl chr 6:125,072,944...125,107,554 		JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of ALAS2 mRNA]; COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of HBB mRNA]; COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of HMBS mRNA] CTD PMID:24141029 NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602 		JBrowse link
G Crh corticotropin releasing hormone increases secretion
multiple interactions		 ISO Hemin results in increased secretion of CRH protein
mesoporphyrin IX analog inhibits the reaction [Hemin results in increased secretion of CRH protein]		 CTD PMID:11232018 NCBI chr 3:19,747,565...19,749,560
Ensembl chr 3:19,747,565...19,749,560 		JBrowse link
G Cybb cytochrome b-245, beta polypeptide multiple interactions ISO Hemin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB mRNA]; Hemin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB protein]; tin protoporphyrin IX inhibits the reaction [Hemin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB mRNA]]; tin protoporphyrin IX inhibits the reaction [Hemin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB protein]] CTD PMID:23272707 NCBI chr  X:9,301,493...9,354,005
Ensembl chr  X:9,301,491...9,354,010 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Hemin inhibits the reaction [Lead inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]]; Hemin inhibits the reaction [Mercuric Chloride inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]]; Hemin inhibits the reaction [sodium arsenite inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]]; Hemin promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in decreased expression of CYP1A1 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of CYP1A1 protein]; Hemin inhibits the reaction [arsenite inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]]		 CTD PMID:20188822 PMID:20837117 PMID:22120038 PMID:22159698 PMID:26747958 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with Hemin] results in decreased expression of CYP1A2 protein; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in decreased expression of CYP1A2 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of CYP1A2 protein]; Hemin inhibits the reaction [arsenite inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]] CTD PMID:22159698 PMID:26747958 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp2a5 cytochrome P450, family 2, subfamily a, polypeptide 5 increases expression
multiple interactions		 EXP Hemin results in increased expression of CYP2A5 mRNA; Hemin results in increased expression of CYP2A5 protein
[tin protoporphyrin IX co-treated with Hemin] affects the localization of CYP2A5 protein; [tin protoporphyrin IX co-treated with Hemin] results in increased expression of CYP2A5 mRNA; [zinc protoporphyrin co-treated with Hemin] results in increased expression of CYP2A5 mRNA; NFE2L2 gene mutant form inhibits the reaction [Hemin results in increased expression of CYP2A5 mRNA]		 CTD PMID:22859313 NCBI chr 7:26,534,764...26,542,689
Ensembl chr 7:26,534,730...26,542,973 		JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 multiple interactions ISO [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with Hemin] results in decreased expression of CYP2B1 protein; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in decreased expression of CYP2B1 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of CYP2B1 protein] CTD PMID:26747958 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049 		JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 multiple interactions ISO Dimethyl Sulfoxide promotes the reaction [Hemin inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]]; Hemin inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]; Hemin promotes the reaction [Dimethyl Sulfoxide inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]] CTD PMID:11368792 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of CYP2E1 mRNA]; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of CYP2E1 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 mRNA]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 protein]
Hemin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]		 CTD PMID:19325051 PMID:26747958 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 ISO
EXP		 Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of DDIT3 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of DDIT3 protein]
Hemin results in increased expression of DDIT3 mRNA		 CTD PMID:26747958 PMID:29749404 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157 		JBrowse link
G Efna1 ephrin A1 multiple interactions ISO [hydroquinone co-treated with Hemin] affects the expression of EFNA1 mRNA CTD PMID:32198055 NCBI chr 3:89,179,037...89,188,258
Ensembl chr 3:89,179,040...89,188,449 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased phosphorylation of EIF2AK3 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased phosphorylation of EIF2AK3 protein] CTD PMID:26747958 NCBI chr 6:70,821,468...70,882,225
Ensembl chr 6:70,821,499...70,882,229 		JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions
increases expression		 ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Hemin results in increased expression of FOS mRNA]; Dactinomycin inhibits the reaction [Hemin results in increased expression of FOS mRNA]; KN 62 inhibits the reaction [Hemin results in increased expression of FOS mRNA]; staurosporine aglycone inhibits the reaction [Hemin results in increased expression of FOS mRNA] CTD PMID:10381381 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Fosl1 fos-like antigen 1 decreases expression ISO Hemin results in decreased expression of FOSL1 protein CTD PMID:20006635 NCBI chr19:5,497,726...5,505,966
Ensembl chr19:5,497,575...5,505,974 		JBrowse link
G Fth1 ferritin heavy polypeptide 1 increases expression ISO
EXP		 Hemin results in increased expression of FTH1 mRNA; Hemin results in increased expression of FTH1 protein CTD PMID:15893546 PMID:16568477 PMID:17469137 PMID:29749404 PMID:31054940 NCBI chr19:9,957,964...9,962,475
Ensembl chr19:9,957,962...9,962,462 		JBrowse link
G Ftl1 ferritin light polypeptide 1 multiple interactions
increases expression		 ISO
EXP		 [Hemin results in increased abundance of Iron] which results in increased expression of FTL mRNA
Hemin results in increased expression of FTL1 mRNA
Hemin results in increased expression of FTL mRNA; Hemin results in increased expression of FTL1 protein		 CTD PMID:12393473 PMID:15893546 PMID:16568477 PMID:29749404 NCBI chr 7:45,107,368...45,109,310
Ensembl chr 7:45,107,368...45,109,308 		JBrowse link
G Gas1 growth arrest specific 1 multiple interactions ISO [Hemin results in increased abundance of Iron] which results in increased expression of GAS1 mRNA CTD PMID:12393473 NCBI chr13:60,322,219...60,325,349
Ensembl chr13:60,322,219...60,325,179 		JBrowse link
G Gata1 GATA binding protein 1 increases expression
multiple interactions		 ISO Hemin results in increased expression of GATA1 mRNA
catechol promotes the reaction [Hemin results in increased expression of GATA1 mRNA]; decitabine inhibits the reaction [hydroquinone inhibits the reaction [Hemin results in increased expression of GATA1 mRNA]]; decitabine inhibits the reaction [Phenol inhibits the reaction [Hemin results in increased expression of GATA1 mRNA]]; Hemin promotes the reaction [catechol results in increased expression of GATA1 mRNA]; hydroquinone inhibits the reaction [Hemin results in increased expression of GATA1 mRNA]; hydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of GATA1 mRNA]; Phenol inhibits the reaction [Hemin results in increased expression of GATA1 mRNA]		 CTD PMID:21414390 PMID:23973255 PMID:28552822 NCBI chr  X:7,825,499...7,842,902
Ensembl chr  X:7,825,499...7,844,310 		JBrowse link
G Gata2 GATA binding protein 2 decreases expression
multiple interactions		 ISO Hemin results in decreased expression of GATA2 mRNA
hydroquinone promotes the reaction [Hemin results in decreased expression of GATA2 mRNA]; hydroxyhydroquinone promotes the reaction [Hemin results in decreased expression of GATA2 mRNA]; Phenol promotes the reaction [Hemin results in decreased expression of GATA2 mRNA]		 CTD PMID:21414390 NCBI chr 6:88,170,873...88,184,014
Ensembl chr 6:88,170,873...88,184,014 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions		 ISO Hemin results in increased expression of GCLC mRNA; Hemin results in increased expression of GCLC protein
[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of GCLC mRNA; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of GCLC protein		 CTD PMID:16631525 PMID:33434570 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767 		JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit multiple interactions
increases expression		 ISO [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of GCLM mRNA; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of GCLM protein
Hemin results in increased expression of GCLM mRNA; Hemin results in increased expression of GCLM protein		 CTD PMID:33434570 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381 		JBrowse link
G Gsr glutathione reductase increases expression
multiple interactions		 ISO Hemin results in increased expression of GSR mRNA; Hemin results in increased expression of GSR protein
[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of GSR mRNA; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of GSR protein		 CTD PMID:33434570 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Gsto1 glutathione S-transferase omega 1 multiple interactions
increases expression		 ISO [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of GSTO1 mRNA
Hemin results in increased expression of GSTO1 mRNA		 CTD PMID:33434570 NCBI chr19:47,843,412...47,853,229
Ensembl chr19:47,843,409...47,853,229 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions ISO Hemin results in increased stability of and results in increased expression of GSTP1 mRNA CTD PMID:15313425 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985 		JBrowse link
G Gstz1 glutathione transferase zeta 1 (maleylacetoacetate isomerase) decreases activity ISO Hemin results in decreased activity of GSTZ1 protein CTD PMID:1846734 NCBI chr12:87,192,102...87,211,497
Ensembl chr12:87,193,939...87,211,497 		JBrowse link
G Hamp hepcidin antimicrobial peptide increases expression
multiple interactions
decreases response to substance		 EXP Hemin results in increased expression of HAMP mRNA
[HAMP mRNA results in decreased susceptibility to Hemin] which results in decreased expression of HIF1A mRNA; [HAMP mRNA results in decreased susceptibility to Hemin] which results in decreased expression of IL6 mRNA; HAMP mRNA promotes the reaction [Hemin results in increased expression of CEBPA mRNA]; necrostatin-1 promotes the reaction [HAMP mRNA results in decreased susceptibility to Hemin]		 CTD PMID:29749404 NCBI chr 7:30,641,793...30,643,454
Ensembl chr 7:30,641,793...30,643,457 		JBrowse link
G Hbb-b1 hemoglobin, beta adult major chain multiple interactions
increases expression		 ISO [catechol co-treated with Hemin] results in increased expression of HBB mRNA; [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA; [S-Adenosylmethionine co-treated with Hemin] results in increased expression of HBB mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA]; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HBB mRNA]; catechol promotes the reaction [Hemin results in increased expression of HBB mRNA]; COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of HBB mRNA]; Decitabine inhibits the reaction [hydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA]]; Decitabine inhibits the reaction [hydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA]]; Decitabine inhibits the reaction [Phenol inhibits the reaction [Hemin results in increased expression of HBB mRNA]]; Hemin promotes the reaction [catechol results in increased expression of HBB mRNA]; hydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA]; hydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA]; Phenol inhibits the reaction [Hemin results in increased expression of HBB mRNA]; trichostatin A inhibits the reaction [hydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA]] CTD PMID:21414390 PMID:23973255 PMID:24141029 PMID:28552822 PMID:30327826
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions
decreases expression		 ISO
EXP		 [Hemin results in decreased abundance of Iron] which results in increased expression of HIF1A mRNA
Hemin results in decreased expression of HIF1A mRNA
[HAMP mRNA results in decreased susceptibility to Hemin] which results in decreased expression of HIF1A mRNA		 CTD PMID:12393473 PMID:29749404 NCBI chr12:73,948,098...73,994,328
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G Hmbs hydroxymethylbilane synthase multiple interactions
increases expression		 ISO [catechol co-treated with Hemin] results in increased expression of HMBS mRNA; [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA; [S-Adenosylmethionine co-treated with Hemin] results in increased expression of HMBS mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA]; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HMBS mRNA]; catechol promotes the reaction [Hemin results in increased expression of HMBS mRNA]; COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of HMBS mRNA]; decitabine inhibits the reaction [hydroquinone inhibits the reaction [Hemin results in increased expression of HMBS mRNA]]; decitabine inhibits the reaction [Phenol inhibits the reaction [Hemin results in increased expression of HMBS mRNA]]; Hemin promotes the reaction [catechol results in increased expression of HMBS mRNA]; hydroquinone inhibits the reaction [Hemin results in increased expression of HMBS mRNA]; hydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of HMBS mRNA]; Phenol inhibits the reaction [Hemin results in increased expression of HMBS mRNA] CTD PMID:21414390 PMID:23973255 PMID:24141029 PMID:28552822 NCBI chr 9:44,247,645...44,255,525
Ensembl chr 9:44,247,636...44,255,525 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
decreases expression
increases activity
decreases response to substance		 ISO
EXP		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of HMOX1 mRNA; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of HMOX1 protein; [Hemin results in increased abundance of Iron] which results in increased expression of HMOX1 mRNA; [Hemin results in increased activity of HMOX1 protein] which results in decreased chemical synthesis of Reactive Oxygen Species; [Hemin results in increased expression of HMOX1 protein] which results in decreased susceptibility to PDGFB protein; BACH1 protein affects the reaction [Hemin results in increased expression of HMOX1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Hemin results in increased expression of HMOX1 mRNA]; diacetyldichlorofluorescein inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; diacetyldichlorofluorescein inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; Genistein inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; Hemin promotes the reaction [Curcumin results in increased expression of HMOX1 mRNA]; herbimycin inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; HMOX1 protein promotes the reaction [Hemin results in decreased susceptibility to IL18 protein]; IFNG protein inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; SESN2 protein inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [Hemin results in increased activity of HMOX1 protein]
Hemin results in increased expression of HMOX1 mRNA; Hemin results in increased expression of HMOX1 protein
Hemin results in decreased expression of HMOX1 protein
[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in decreased expression of HMOX1 protein; [Hemin co-treated with Fructose] results in increased expression of HMOX1 protein; [Hemin co-treated with Nitroglycerin] results in increased expression of HMOX1 mRNA; [Hemin co-treated with Nitroglycerin] results in increased expression of HMOX1 protein; [Streptozocin co-treated with Hemin] results in increased activity of HMOX1 protein; [tin protoporphyrin IX co-treated with Hemin] results in increased expression of HMOX1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Hemin results in decreased expression of HMOX1 protein]; chromium mesoporphyrin inhibits the reaction [[Streptozocin co-treated with Hemin] results in increased activity of HMOX1 protein]; Hemin inhibits the reaction [Cyclophosphamide results in increased expression of HMOX1 mRNA]; Hemin inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]]; Hemin inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; Hemin promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]; Hemin promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]; Hemin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of HMOX1 mRNA]; Hemin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Acetaminophen results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Carbon Monoxide results in increased activity of HMOX1 protein]; Hemin promotes the reaction [Carbon Monoxide results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Carbon Tetrachloride results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Cyclophosphamide results in increased expression of HMOX1 mRNA]; Hemin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]; Hemin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Paraquat results in increased expression of HMOX1 mRNA]; protoporphyrin IX inhibits the reaction [Hemin results in increased activity of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [Hemin promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]]; tin protoporphyrin IX inhibits the reaction [Hemin results in decreased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Hemin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]]; zinc protoporphyrin inhibits the reaction [Hemin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Hemin results in increased expression of HMOX1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; [tin protoporphyrin IX co-treated with Hemin] results in increased expression of HMOX1 mRNA; [zinc protoporphyrin co-treated with Hemin] results in increased expression of HMOX1 mRNA; Acetylcysteine inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; Apigenin inhibits the reaction [Hemin results in increased activity of HMOX1 protein]; Apigenin inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; Apigenin inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; Dichlororibofuranosylbenzimidazole inhibits the reaction [Hemin results in increased activity of HMOX1 protein]; Dichlororibofuranosylbenzimidazole inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; Dichlororibofuranosylbenzimidazole inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; Hemin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMOX1 protein]; Hemin promotes the reaction [3-hydroxyflavone results in increased expression of HMOX1 protein]; Hemin promotes the reaction [baicalein results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Cisplatin results in increased expression of HMOX1 protein]; Hemin promotes the reaction [kaempferol results in increased expression of HMOX1 protein]; Hemin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Quercetin results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Hemin results in increased expression of HMOX1 mRNA]; Quercetin inhibits the reaction [Hemin results in increased expression of HMOX1 protein]
HMOX1 protein results in decreased susceptibility to Hemin		 CTD PMID:3343248 PMID:8764571 PMID:9337616 PMID:9722676 PMID:10349844 More... NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hmox2 heme oxygenase 2 decreases response to substance ISO
EXP		 HMOX2 protein results in decreased susceptibility to Hemin CTD PMID:15589375 PMID:16459095 NCBI chr16:4,544,225...4,584,606
Ensembl chr16:4,544,225...4,584,606 		JBrowse link
G Hsf1 heat shock factor 1 increases activity ISO Hemin results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr15:76,361,562...76,385,355
Ensembl chr15:76,361,622...76,386,113 		JBrowse link
G Hspa1l heat shock protein 1-like multiple interactions ISO [Hemin results in increased abundance of Iron] which results in increased expression of HSPA1L mRNA CTD PMID:12393473 NCBI chr17:35,191,679...35,198,204
Ensembl chr17:35,191,679...35,198,261 		JBrowse link
G Hspa9 heat shock protein 9 multiple interactions ISO [Hemin results in increased abundance of Iron] which results in increased expression of HSPA9 mRNA CTD PMID:12393473 NCBI chr18:35,070,467...35,087,404
Ensembl chr18:35,070,467...35,087,410 		JBrowse link
G Hsph1 heat shock 105kDa/110kDa protein 1 multiple interactions ISO [Hemin results in increased abundance of Iron] which results in increased expression of HSPH1 mRNA CTD PMID:12393473 NCBI chr 5:149,540,308...149,562,594
Ensembl chr 5:149,537,752...149,559,841 		JBrowse link
G Ifng interferon gamma multiple interactions ISO IFNG protein inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA] CTD PMID:10349844 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Il18 interleukin 18 multiple interactions
decreases response to substance		 ISO Hemin inhibits the reaction [IL18 protein results in decreased expression of MAPK11 protein]; Hemin inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]; Hemin inhibits the reaction [IL18 protein results in increased expression of MAPK14 protein]; Hemin inhibits the reaction [IL18 protein results in increased expression of PTEN protein]; HMOX1 protein promotes the reaction [Hemin results in decreased susceptibility to IL18 protein]; zinc protoporphyrin inhibits the reaction [Hemin results in decreased susceptibility to IL18 protein] CTD PMID:18215737 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 EXP [HAMP mRNA results in decreased susceptibility to Hemin] which results in decreased expression of IL6 mRNA
Hemin results in increased expression of IL6 mRNA		 CTD PMID:29749404 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Ins2 insulin II multiple interactions ISO Hemin inhibits the reaction [Fructose results in increased expression of INS protein] CTD PMID:25268984 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118 		JBrowse link
G Ireb2 iron responsive element binding protein 2 multiple interactions ISO Hemin results in decreased expression of and results in decreased activity of IREB2 protein CTD PMID:16568477 NCBI chr 9:54,769,942...54,819,818
Ensembl chr 9:54,771,073...54,819,814 		JBrowse link
G Ivl involucrin decreases expression ISO Hemin results in decreased expression of IVL mRNA CTD PMID:20006635 NCBI chr 3:92,478,206...92,481,097
Ensembl chr 3:92,478,209...92,481,042 		JBrowse link
G Jun jun proto-oncogene multiple interactions
decreases expression		 ISO [Hemin results in decreased abundance of Iron] which results in increased expression of JUN mRNA
Hemin results in decreased expression of JUN mRNA
Hemin promotes the reaction [Paraquat results in increased phosphorylation of JUN protein]		 CTD PMID:12393473 PMID:19080378 PMID:20016031 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Keap1 kelch-like ECH-associated protein 1 decreases expression EXP Hemin results in decreased expression of KEAP1 protein CTD PMID:27777014 NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657 		JBrowse link
G Lox lysyl oxidase multiple interactions ISO [Hemin results in decreased abundance of Iron] which results in increased expression of LOX mRNA CTD PMID:12393473 NCBI chr18:52,649,132...52,662,939
Ensembl chr18:52,649,139...52,662,939 		JBrowse link
G Magi1 membrane associated guanylate kinase, WW and PDZ domain containing 1 multiple interactions ISO [Hemin co-treated with MIR486-1 mRNA] affects the expression of MAGI1 mRNA; [Hemin co-treated with MIR486-1 mRNA] affects the expression of MAGI1 protein; [hydroquinone co-treated with Hemin] affects the expression of MAGI1 mRNA; [hydroquinone co-treated with Hemin] affects the expression of MAGI1 protein; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A protein]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 protein]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RASSF5 mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RASSF5 protein] CTD PMID:32198055 NCBI chr 6:93,652,434...94,260,901
Ensembl chr 6:93,652,436...94,260,898 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO Hemin results in increased phosphorylation of MAPK1 protein
diacetyldichlorofluorescein inhibits the reaction [Hemin results in increased phosphorylation of MAPK1 protein]		 CTD PMID:16959797 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk11 mitogen-activated protein kinase 11 multiple interactions ISO Hemin inhibits the reaction [IL18 protein results in decreased expression of MAPK11 protein] CTD PMID:18215737 NCBI chr15:89,026,685...89,033,809
Ensembl chr15:89,026,689...89,033,831 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 multiple interactions ISO Hemin inhibits the reaction [IL18 protein results in increased expression of MAPK14 protein] CTD PMID:18215737 NCBI chr17:28,910,243...28,967,379
Ensembl chr17:28,910,303...28,967,380 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO diacetyldichlorofluorescein inhibits the reaction [Hemin results in increased phosphorylation of MAPK3 protein] CTD PMID:16959797 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Hemin promotes the reaction [Paraquat results in increased phosphorylation of MAPK8 protein] CTD PMID:19080378 NCBI chr14:33,099,855...33,169,215
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
decreases expression		 ISO chromium mesoporphyrin inhibits the reaction [Hemin inhibits the reaction [Streptozocin results in increased expression of MAPK9 mRNA]]; Hemin inhibits the reaction [Streptozocin results in increased expression of MAPK9 mRNA]
Hemin results in decreased expression of MAPK9 mRNA		 CTD PMID:19190261 PMID:20016031 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248 		JBrowse link
G Mfn1 mitofusin 1 multiple interactions ISO Hemin inhibits the reaction [Lipopolysaccharides results in decreased expression of MFN1 mRNA]; Hemin inhibits the reaction [Lipopolysaccharides results in decreased expression of MFN1 protein]; Hemin inhibits the reaction [zinc protoporphyrin promotes the reaction [Lipopolysaccharides results in decreased expression of MFN1 mRNA]]; Hemin inhibits the reaction [zinc protoporphyrin promotes the reaction [Lipopolysaccharides results in decreased expression of MFN1 protein]]; zinc protoporphyrin inhibits the reaction [Hemin inhibits the reaction [Lipopolysaccharides results in decreased expression of MFN1 mRNA]]; zinc protoporphyrin inhibits the reaction [Hemin inhibits the reaction [Lipopolysaccharides results in decreased expression of MFN1 protein]] CTD PMID:27830717 NCBI chr 3:32,583,594...32,633,374
Ensembl chr 3:32,583,614...32,633,388 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 multiple interactions ISO Hemin inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein] CTD PMID:19111564 NCBI chr 6:138,117,525...138,133,753
Ensembl chr 6:138,117,314...138,133,753 		JBrowse link
G Mir126a microRNA 126a decreases expression ISO Hemin results in decreased expression of MIR126 mRNA CTD PMID:28733890 NCBI chr 2:26,481,369...26,481,441
Ensembl chr 2:26,481,369...26,481,441 		JBrowse link
G Mir451a microRNA 451a multiple interactions
increases expression		 ISO hydroquinone affects the reaction [Hemin results in increased expression of MIR451A mRNA] CTD PMID:28733890 NCBI chr11:77,963,996...77,964,067
Ensembl chr11:77,963,996...77,964,067 		JBrowse link
G Mir486 microRNA 486 multiple interactions
increases expression		 ISO [Hemin co-treated with MIR486-1 mRNA] affects the expression of MAGI1 mRNA; [Hemin co-treated with MIR486-1 mRNA] affects the expression of MAGI1 protein; [Hemin co-treated with MIR486-1 mRNA] affects the expression of RASSF5 mRNA; [Hemin co-treated with MIR486-1 mRNA] affects the expression of RASSF5 protein; hydroquinone affects the reaction [[Hemin co-treated with MIR486-1 mRNA] affects the expression of RASSF5 mRNA]; hydroquinone inhibits the reaction [Hemin results in increased expression of MIR486-1 mRNA]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A mRNA]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A protein]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 mRNA]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 protein] CTD PMID:32198055 NCBI chr 8:23,632,571...23,632,698
Ensembl chr 8:23,632,571...23,632,698 		JBrowse link
G Mmp1b matrix metallopeptidase 1b (interstitial collagenase) increases expression ISO Hemin results in increased expression of MMP1 protein CTD PMID:19136476 NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Hemin inhibits the reaction [Cyclophosphamide results in increased activity of MPO protein] CTD PMID:17979934 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Mt2 metallothionein 2 multiple interactions ISO [Hemin results in decreased abundance of Iron] which results in increased expression of MT2A mRNA CTD PMID:12393473 NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196 		JBrowse link
G Myc myelocytomatosis oncogene multiple interactions ISO [Hemin results in increased abundance of Iron] which results in increased expression of MYC mRNA CTD PMID:12393473 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
G Nfe2 nuclear factor, erythroid derived 2 increases expression
multiple interactions		 ISO Hemin results in increased expression of NFE2 mRNA
catechol promotes the reaction [Hemin results in increased expression of NFE2 mRNA]; Hemin promotes the reaction [catechol results in increased expression of NFE2 mRNA]; hydroquinone inhibits the reaction [Hemin results in increased expression of NFE2 mRNA]; hydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of NFE2 mRNA]; Phenol inhibits the reaction [Hemin results in increased expression of NFE2 mRNA]		 CTD PMID:21414390 PMID:28552822 NCBI chr15:103,156,639...103,166,830
Ensembl chr15:103,156,639...103,166,830 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions
increases expression
affects localization
decreases expression		 ISO
EXP		 [Antineoplastic Agents binds to and results in decreased activity of NFE2L2 protein] inhibits the reaction [Hemin results in increased expression of SESN2 protein]; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of and affects the localization of NFE2L2 protein; diacetyldichlorofluorescein inhibits the reaction [Hemin affects the localization of NFE2L2 protein]; Hemin promotes the reaction [NFE2L2 protein binds to NQO1 promoter]; Hemin results in increased expression of and affects the localization of NFE2L2 protein; SESN2 protein inhibits the reaction [Hemin results in increased expression of NFE2L2 protein]
[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Hemin] affects the localization of NFE2L2 protein; Hemin promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NFE2L2 protein]; tin protoporphyrin IX inhibits the reaction [Hemin results in decreased expression of NFE2L2 protein]; tin protoporphyrin IX inhibits the reaction [Hemin results in increased expression of NFE2L2 protein]; zinc protoporphyrin inhibits the reaction [Hemin results in increased expression of NFE2L2 protein]
NFE2L2 gene mutant form inhibits the reaction [Hemin results in increased expression of CYP2A5 mRNA]; NFE2L2 protein affects the reaction [Hemin results in increased expression of HMOX1 mRNA]		 CTD PMID:10473555 PMID:16959797 PMID:21464371 PMID:21525764 PMID:22859313 More... NCBI chr 2:75,505,857...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP
ISO		 Hemin inhibits the reaction [Cisplatin results in increased expression of NOS2 protein]; Hemin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Hemin promotes the reaction [3-hydroxyflavone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Hemin promotes the reaction [baicalein inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Hemin promotes the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]]; Hemin promotes the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Hemin promotes the reaction [naringenin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]]; Hemin promotes the reaction [Quercetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]
Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of NOS2 mRNA]; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of NOS2 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of NOS2 mRNA]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of NOS2 protein]		 CTD PMID:14563492 PMID:15316927 PMID:26747958 PMID:27815112 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell multiple interactions ISO [Nitroglycerin co-treated with Hemin] results in increased expression of NOS3 mRNA CTD PMID:17541025 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression
multiple interactions		 ISO Hemin results in increased expression of NQO1 mRNA; Hemin results in increased expression of NQO1 protein
[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of NQO1 mRNA; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of NQO1 protein; Hemin promotes the reaction [NFE2L2 protein binds to NQO1 promoter]; SESN2 protein inhibits the reaction [Hemin results in increased expression of NQO1 protein]		 CTD PMID:21464371 PMID:31054940 PMID:33434570 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions ISO Hemin inhibits the reaction [manganese chloride affects the expression of NRF1 protein] CTD PMID:30040983 NCBI chr 6:30,047,984...30,153,457
Ensembl chr 6:30,047,987...30,153,457 		JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) multiple interactions ISO [Hemin co-treated with hexamethylene bisacetamide] inhibits the reaction [CHD4 protein binds to OGT protein] CTD PMID:27231347 NCBI chr  X:100,683,617...100,727,957
Ensembl chr  X:100,683,666...100,727,957 		JBrowse link
G Pde5a phosphodiesterase 5A, cGMP-specific decreases expression ISO Hemin results in decreased expression of PDE5A protein CTD PMID:16839318 NCBI chr 3:122,522,807...122,653,023
Ensembl chr 3:122,522,596...122,653,023 		JBrowse link
G Pdgfb platelet derived growth factor, B polypeptide multiple interactions ISO [Hemin results in increased expression of HMOX1 protein] which results in decreased susceptibility to PDGFB protein CTD PMID:20961405 NCBI chr15:79,880,066...79,899,178
Ensembl chr15:79,880,075...79,899,178 		JBrowse link
G Pdgfrb platelet derived growth factor receptor, beta polypeptide multiple interactions ISO [hydroquinone co-treated with Hemin] affects the expression of PDGFRB mRNA CTD PMID:32198055 NCBI chr18:61,178,194...61,218,139
Ensembl chr18:61,178,222...61,218,133 		JBrowse link
G Pmp22 peripheral myelin protein 22 multiple interactions ISO [Hemin results in decreased abundance of Iron] which results in increased expression of PMP22 mRNA CTD PMID:12393473 NCBI chr11:63,019,808...63,050,373
Ensembl chr11:63,019,808...63,050,373 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions
decreases activity		 ISO Dimethyl Sulfoxide promotes the reaction [Hemin inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]]; Dimethyl Sulfoxide promotes the reaction [Hemin results in decreased activity of POR protein]; Hemin inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]; Hemin promotes the reaction [Dimethyl Sulfoxide inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]]; Hemin promotes the reaction [Dimethyl Sulfoxide results in decreased activity of POR protein] CTD PMID:11368792 NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha multiple interactions ISO Hemin inhibits the reaction [manganese chloride affects the expression of PPARGC1A protein] CTD PMID:30040983 NCBI chr 5:51,611,591...52,273,337
Ensembl chr 5:51,611,592...51,725,068 		JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO Hemin inhibits the reaction [IL18 protein results in increased expression of PTEN protein] CTD PMID:18215737 NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560 		JBrowse link
G Ptger2 prostaglandin E receptor 2 (subtype EP2) increases response to substance EXP PTGER2 gene mutant form results in increased susceptibility to Hemin CTD PMID:25451967 NCBI chr14:45,225,568...45,241,277
Ensembl chr14:45,225,652...45,241,277 		JBrowse link
G Rap1a RAS-related protein 1a multiple interactions ISO [hydroquinone co-treated with Hemin] affects the expression of RAP1A mRNA; [hydroquinone co-treated with Hemin] affects the expression of RAP1A protein; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A protein]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A mRNA]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A protein] CTD PMID:32198055 NCBI chr 3:105,634,576...105,708,740
Ensembl chr 3:105,634,583...105,708,652 		JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor (GEF) 2 multiple interactions ISO [hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 mRNA; [hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 protein; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 protein]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 mRNA]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 protein] CTD PMID:32198055 NCBI chr 3:78,969,818...79,194,681
Ensembl chr 3:78,969,823...79,193,824 		JBrowse link
G Rassf5 Ras association (RalGDS/AF-6) domain family member 5 multiple interactions ISO [Hemin co-treated with MIR486-1 mRNA] affects the expression of RASSF5 mRNA; [Hemin co-treated with MIR486-1 mRNA] affects the expression of RASSF5 protein; [hydroquinone co-treated with Hemin] affects the expression of RASSF5 mRNA; [hydroquinone co-treated with Hemin] affects the expression of RASSF5 protein; hydroquinone affects the reaction [[Hemin co-treated with MIR486-1 mRNA] affects the expression of RASSF5 mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RASSF5 mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RASSF5 protein] CTD PMID:32198055 NCBI chr 1:131,104,147...131,172,915
Ensembl chr 1:131,104,147...131,172,995 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions
decreases expression		 ISO chromium mesoporphyrin inhibits the reaction [Hemin inhibits the reaction [Streptozocin results in increased expression of RELA mRNA]]; Hemin inhibits the reaction [Streptozocin results in increased expression of RELA mRNA]
Hemin results in decreased expression of RELA mRNA		 CTD PMID:19190261 PMID:20016031 NCBI chr19:5,687,569...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Sesn2 sestrin 2 multiple interactions
affects response to substance
increases expression		 ISO
EXP		 [Antineoplastic Agents binds to and results in decreased activity of NFE2L2 protein] inhibits the reaction [Hemin results in increased expression of SESN2 protein]; Acetylcysteine inhibits the reaction [Hemin results in increased expression of SESN2 protein]; SESN2 protein inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; SESN2 protein inhibits the reaction [Hemin results in increased expression of NFE2L2 protein]; SESN2 protein inhibits the reaction [Hemin results in increased expression of NQO1 protein]
SESN2 protein affects the susceptibility to Hemin
[SESN2 protein affects the susceptibility to Hemin] which results in decreased expression of CASP3 protein modified form		 CTD PMID:31054940 NCBI chr 4:132,220,115...132,237,767
Ensembl chr 4:132,219,343...132,237,812 		JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 multiple interactions ISO chromium mesoporphyrin inhibits the reaction [Hemin inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]]; Hemin inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein] CTD PMID:19190261 NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions ISO Hemin promotes the reaction [Acetaminophen results in increased expression of SOD2 protein] CTD PMID:12051994 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Tfap2c transcription factor AP-2, gamma decreases expression ISO Hemin results in decreased expression of TFAP2C mRNA CTD PMID:20016031 NCBI chr 2:172,387,599...172,400,542
Ensembl chr 2:172,391,513...172,400,542 		JBrowse link
G Tfrc transferrin receptor decreases expression
multiple interactions		 ISO Hemin results in decreased expression of TFRC protein
Hemin results in decreased expression of TFRC mRNA; Hemin results in decreased expression of TFRC protein
[Hemin results in decreased abundance of Iron] which results in increased expression of TFRC mRNA; hydroquinone promotes the reaction [Hemin results in decreased expression of TFRC mRNA]; hydroxyhydroquinone promotes the reaction [Hemin results in decreased expression of TFRC mRNA]; Phenol promotes the reaction [Hemin results in decreased expression of TFRC mRNA]		 CTD PMID:12393473 PMID:16568477 PMID:16760464 PMID:21414390 PMID:25576684 NCBI chr16:32,427,714...32,451,612
Ensembl chr16:32,427,738...32,451,612 		JBrowse link
G Tgm2 transglutaminase 2, C polypeptide multiple interactions ISO [Hemin co-treated with Tretinoin] affects the localization of TGM2 protein CTD PMID:15556610 NCBI chr 2:157,958,325...157,988,312
Ensembl chr 2:157,958,322...157,988,356 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 [Hemin co-treated with indole-3-carbinol co-treated with 1,2-Dimethylhydrazine] affects the expression of TNF mRNA; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of TNF mRNA]; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of TNF protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of TNF mRNA]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of TNF protein]; Hemin inhibits the reaction [Cadmium Chloride results in increased expression of TNF]; Hemin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]
Hemin inhibits the reaction [Cisplatin results in increased expression of TNF protein]		 CTD PMID:17173083 PMID:19150641 PMID:26747958 PMID:27815112 PMID:29269057 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Vasp vasodilator-stimulated phosphoprotein multiple interactions ISO Hemin inhibits the reaction [Nitroglycerin results in decreased phosphorylation of VASP protein] CTD PMID:17541025 NCBI chr 7:18,990,854...19,005,779
Ensembl chr 7:18,990,854...19,005,742 		JBrowse link
G Zfp36 zinc finger protein 36 multiple interactions
increases expression		 EXP zinc protoporphyrin inhibits the reaction [Hemin results in increased expression of ZFP36 mRNA] CTD PMID:24095726 NCBI chr 7:28,076,209...28,078,653
Ensembl chr 7:28,076,209...28,079,678 		JBrowse link
hydroxocobalamin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gucy1a1 guanylate cyclase 1, soluble, alpha 1 multiple interactions ISO Hydroxocobalamin results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein] CTD PMID:22171090 NCBI chr 3:81,999,734...82,053,253
Ensembl chr 3:81,999,734...82,053,096 		JBrowse link
G Gucy1b1 guanylate cyclase 1, soluble, beta 1 multiple interactions ISO Hydroxocobalamin results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein] CTD PMID:22171090 NCBI chr 3:81,939,311...81,982,018
Ensembl chr 3:81,939,313...81,981,996 		JBrowse link
G Mmachc methylmalonic aciduria cblC type, with homocystinuria affects binding ISO Hydroxocobalamin binds to MMACHC protein CTD PMID:19700356 NCBI chr 4:116,559,631...116,565,582
Ensembl chr 4:116,559,476...116,565,603 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase multiple interactions ISO [Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form; Aluminum inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Arsenic inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Glutathione inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione inhibits the reaction [Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione promotes the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Lead inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; mecobalamin inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Mercury inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form] CTD PMID:26989453 NCBI chr13:12,196,217...12,273,090
Ensembl chr13:12,197,598...12,272,999 		JBrowse link
Isocoproporphyrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpox coproporphyrinogen oxidase increases chemical synthesis
affects abundance		 ISO CPOX polymorphism results in increased chemical synthesis of isocoproporphyrin analog
CPOX polymorphism affects the abundance of isocoproporphyrin analog		 CTD PMID:15967199 PMID:16214298 NCBI chr16:58,490,571...58,500,754
Ensembl chr16:58,490,655...58,537,999 		JBrowse link
meso-tetrakis(N-methyl-4-pyridyl)porphine(4+) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Myc myelocytomatosis oncogene multiple interactions ISO tetra(4-N-methylpyridyl)porphine binds to and affects the folding of MYC gene CTD PMID:15740131 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
mesoporphyrin IX term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crh corticotropin releasing hormone multiple interactions ISO mesoporphyrin IX analog inhibits the reaction [Hemin results in increased secretion of CRH protein] CTD PMID:11232018 NCBI chr 3:19,747,565...19,749,560
Ensembl chr 3:19,747,565...19,749,560 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP [mesoporphyrin IX binds to HPX protein] which results in increased expression of HMOX1 mRNA; hexamethylene bisacetamide inhibits the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of HMOX1 mRNA] CTD PMID:12042074 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hpx hemopexin multiple interactions EXP [mesoporphyrin IX binds to HPX protein] which results in increased expression of HMOX1 mRNA; [mesoporphyrin IX binds to HPX protein] which results in increased expression of MT1 mRNA; [mesoporphyrin IX binds to HPX protein] which results in increased expression of MT2 mRNA; hexamethylene bisacetamide inhibits the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of HMOX1 mRNA]; hexamethylene bisacetamide promotes the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of MT1 mRNA]; hexamethylene bisacetamide promotes the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of MT2 mRNA] CTD PMID:12042074 NCBI chr 7:105,240,818...105,249,323
Ensembl chr 7:105,240,820...105,249,344 		JBrowse link
G Mt1 metallothionein 1 multiple interactions EXP [mesoporphyrin IX binds to HPX protein] which results in increased expression of MT1 mRNA; hexamethylene bisacetamide promotes the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of MT1 mRNA] CTD PMID:12042074 NCBI chr 8:94,905,214...94,906,955
Ensembl chr 8:94,905,710...94,906,955 		JBrowse link
G Mt2 metallothionein 2 multiple interactions EXP [mesoporphyrin IX binds to HPX protein] which results in increased expression of MT2 mRNA; hexamethylene bisacetamide promotes the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of MT2 mRNA] CTD PMID:12042074 NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196 		JBrowse link
methylcobalamin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Capn1 calpain 1 multiple interactions ISO mecobalamin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CAPN1 protein] CTD PMID:33739591 NCBI chr19:6,038,573...6,065,855
Ensembl chr19:6,038,573...6,065,927 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO mecobalamin inhibits the reaction [Homocysteine results in increased activity of CASP3 protein] CTD PMID:21237187 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO mecobalamin inhibits the reaction [Homocysteine results in increased activity of CASP7 protein] CTD PMID:21237187 NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776 		JBrowse link
G Ifng interferon gamma multiple interactions ISO mecobalamin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of IFNG protein] CTD PMID:33739591 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO mecobalamin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased activity of MMP2 protein] CTD PMID:33739591 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase multiple interactions
increases activity		 ISO Aluminum inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]; Arsenic inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]; Buthionine Sulfoximine inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]; Lead inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]; mecobalamin inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Mercury inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]; Thimerosal inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form] CTD PMID:26989453 NCBI chr13:12,196,217...12,273,090
Ensembl chr13:12,197,598...12,272,999 		JBrowse link
pheophorbide a term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) multiple interactions ISO ABCG2 protein affects the reaction [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased transport of pheophorbide a]; ABCG2 protein affects the reaction [Mifepristone results in decreased transport of pheophorbide a] CTD PMID:30217652 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661 		JBrowse link
porphyrins term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) decreases activity
multiple interactions		 ISO Porphyrins results in decreased activity of ABCG2 protein
Porphyrins inhibits the reaction [ABCG2 protein results in decreased susceptibility to Irinotecan]; Porphyrins inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Porphyrins inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]		 CTD PMID:34717915 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661 		JBrowse link
G Anpep alanyl (membrane) aminopeptidase decreases activity ISO Porphyrins analog results in decreased activity of ANPEP protein CTD PMID:19189318 NCBI chr 7:79,471,551...79,497,958
Ensembl chr 7:79,471,551...79,510,807 		JBrowse link
G Bax BCL2-associated X protein increases expression ISO Porphyrins results in increased expression of BAX mRNA CTD PMID:26468117 NCBI chr 7:45,111,119...45,116,344
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 increases expression ISO Porphyrins results in increased expression of BCL2 mRNA CTD PMID:26468117 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Casp3 caspase 3 increases expression ISO Porphyrins results in increased expression of CASP3 mRNA CTD PMID:26468117 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp8 caspase 8 increases expression ISO Porphyrins results in increased expression of CASP8 mRNA CTD PMID:26468117 NCBI chr 1:58,834,398...58,886,662
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Cat catalase decreases expression
increases expression		 ISO Porphyrins results in decreased expression of CAT protein
Porphyrins results in increased expression of CAT mRNA		 CTD PMID:26468117 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression ISO Porphyrins results in decreased expression of GPX1 mRNA CTD PMID:26468117 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542 		JBrowse link
G Keap1 kelch-like ECH-associated protein 1 increases expression ISO Porphyrins results in increased expression of KEAP1 mRNA CTD PMID:31385236 NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases expression ISO Porphyrins results in increased expression of NFE2L2 mRNA CTD PMID:31385236 NCBI chr 2:75,505,857...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Sod1 superoxide dismutase 1, soluble increases expression
decreases expression		 ISO Porphyrins results in increased expression of SOD1 mRNA
Porphyrins results in decreased expression of SOD1 protein		 CTD PMID:26468117 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial decreases expression
increases expression		 ISO Porphyrins results in decreased expression of SOD2 protein
Porphyrins results in increased expression of SOD2 mRNA		 CTD PMID:26468117 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Tspo translocator protein affects transport ISO TSPO protein affects the transport of Porphyrins CTD PMID:11020479 NCBI chr15:83,447,774...83,458,404
Ensembl chr15:83,447,793...83,458,404 		JBrowse link
protoporphyrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7b ATPase, Cu++ transporting, beta polypeptide multiple interactions
decreases chemical synthesis		 ISO ATP7B gene mutant form promotes the reaction [Copper results in decreased abundance of protoporphyrin IX]
ATP7B gene mutant form results in decreased chemical synthesis of protoporphyrin IX		 CTD PMID:19888908 NCBI chr 8:22,482,799...22,550,632
Ensembl chr 8:22,482,801...22,550,321 		JBrowse link
G Casp3 caspase 3 multiple interactions
decreases activity
increases activity		 ISO Doxorubicin promotes the reaction [protoporphyrin IX results in increased activity of CASP3 protein]
protoporphyrin IX results in decreased activity of CASP3 protein		 CTD PMID:16051694 PMID:18845130 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp8 caspase 8 decreases activity ISO protoporphyrin IX results in decreased activity of CASP8 protein CTD PMID:16051694 NCBI chr 1:58,834,398...58,886,662
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) multiple interactions ISO protoporphyrin IX inhibits the reaction [[Sulfasalazine results in increased expression of HMOX1 protein] which results in increased expression of CDKN1A protein] CTD PMID:19234301 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Cycs cytochrome c, somatic affects localization ISO protoporphyrin IX affects the localization of CYCS protein CTD PMID:18845130 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518 		JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO protoporphyrin IX results in decreased expression of EGFR protein CTD PMID:23624237 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158 		JBrowse link
G Epas1 endothelial PAS domain protein 1 affects localization ISO protoporphyrin IX affects the localization of EPAS1 protein CTD PMID:23624237 NCBI chr17:87,061,292...87,140,838
Ensembl chr17:87,061,128...87,140,838 		JBrowse link
G Fech ferrochelatase affects abundance EXP FECH protein affects the abundance of protoporphyrin IX CTD PMID:29906468 NCBI chr18:64,589,613...64,622,169
Ensembl chr18:64,585,985...64,623,322 		JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression ISO protoporphyrin IX results in increased expression of FOS mRNA CTD PMID:10381381 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Gucy1a1 guanylate cyclase 1, soluble, alpha 1 multiple interactions ISO Polysorbates promotes the reaction [protoporphyrin IX results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; protoporphyrin IX results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein] CTD PMID:22171090 NCBI chr 3:81,999,734...82,053,253
Ensembl chr 3:81,999,734...82,053,096 		JBrowse link
G Gucy1b1 guanylate cyclase 1, soluble, beta 1 multiple interactions ISO Polysorbates promotes the reaction [protoporphyrin IX results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; protoporphyrin IX results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein] CTD PMID:22171090 NCBI chr 3:81,939,311...81,982,018
Ensembl chr 3:81,939,313...81,981,996 		JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions
affects localization
increases degradation
decreases activity		 ISO Adenosine Triphosphate inhibits the reaction [protoporphyrin IX results in decreased activity of HIF1A protein]
protoporphyrin IX affects the localization of HIF1A protein
protoporphyrin IX results in increased degradation of HIF1A protein		 CTD PMID:23624237 NCBI chr12:73,948,098...73,994,328
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases activity		 ISO protoporphyrin IX inhibits the reaction [[Sulfasalazine results in increased expression of HMOX1 protein] which results in increased expression of CDKN1A protein]; protoporphyrin IX inhibits the reaction [Hemin results in increased activity of HMOX1 protein]
protoporphyrin IX results in decreased activity of HMOX1 protein		 CTD PMID:18845130 PMID:19234301 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 decreases response to substance ISO HSP90AA1 protein results in decreased susceptibility to protoporphyrin IX CTD PMID:23624237 NCBI chr12:110,657,470...110,662,829
Ensembl chr12:110,657,039...110,669,162 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO protoporphyrin IX results in decreased expression of MMP2 mRNA; protoporphyrin IX results in decreased expression of MMP2 protein CTD PMID:23624237 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP protoporphyrin IX inhibits the reaction [Plant Extracts inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]] CTD PMID:21827494 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell decreases expression ISO protoporphyrin IX results in decreased expression of NOS3 protein CTD PMID:23624237 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions EXP NR1I3 protein affects the reaction [oxadiazon results in increased abundance of protoporphyrin IX] CTD PMID:26710982 NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases expression ISO protoporphyrin IX results in decreased expression of NR3C1 protein CTD PMID:23624237 NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474 		JBrowse link
G Plat plasminogen activator, tissue decreases expression ISO protoporphyrin IX results in decreased expression of PLAT protein CTD PMID:23624237 NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP protoporphyrin IX inhibits the reaction [Plant Extracts inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]] CTD PMID:21827494 NCBI chr 1:149,975,782...149,983,985
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 decreases expression ISO protoporphyrin IX results in decreased expression of SLC2A1 mRNA CTD PMID:23624237 NCBI chr 4:118,965,942...118,994,527
Ensembl chr 4:118,965,908...118,995,180 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO protoporphyrin IX inhibits the reaction [16-(4-fluorophenoxy)lipoxin A4 inhibits the reaction [TNF results in increased expression of VCAM1 protein]] CTD PMID:15901601 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tspo translocator protein decreases abundance ISO TSPO protein results in decreased abundance of protoporphyrin IX CTD PMID:11020479 NCBI chr15:83,447,774...83,458,404
Ensembl chr15:83,447,793...83,458,404 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO protoporphyrin IX inhibits the reaction [16-(4-fluorophenoxy)lipoxin A4 inhibits the reaction [TNF results in increased expression of VCAM1 protein]] CTD PMID:15901601 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337 		JBrowse link
protoporphyrinogen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpox coproporphyrinogen oxidase multiple interactions
increases chemical synthesis		 ISO
EXP		 Mercury inhibits the reaction [CPOX protein results in increased chemical synthesis of protoporphyrinogen]; TGFB1 protein promotes the reaction [CPOX protein results in increased chemical synthesis of protoporphyrinogen] CTD PMID:11248690 PMID:19339664 NCBI chr16:58,490,571...58,500,754
Ensembl chr16:58,490,655...58,537,999 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO TGFB1 protein promotes the reaction [CPOX protein results in increased chemical synthesis of protoporphyrinogen] CTD PMID:11248690 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
protoporphyrins term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Areg amphiregulin increases expression EXP Protoporphyrins results in increased expression of AREG protein CTD PMID:19267999 NCBI chr 5:91,287,458...91,296,291
Ensembl chr 5:91,287,458...91,296,291 		JBrowse link
G Btc betacellulin, epidermal growth factor family member increases expression EXP Protoporphyrins results in increased expression of BTC protein CTD PMID:19267999 NCBI chr 5:91,505,120...91,550,853
Ensembl chr 5:91,505,120...91,550,853 		JBrowse link
G Ereg epiregulin increases expression EXP Protoporphyrins results in increased expression of EREG protein CTD PMID:19267999 NCBI chr 5:91,222,476...91,241,508
Ensembl chr 5:91,222,481...91,241,505 		JBrowse link
verteporfin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amotl1 angiomotin-like 1 decreases response to substance
multiple interactions		 ISO Verteporfin results in decreased susceptibility to AMOTL1 protein
Verteporfin inhibits the reaction [AMOTL1 protein results in increased activity of YAP1 protein]		 CTD PMID:34480788 NCBI chr 9:14,453,262...14,574,408
Ensembl chr 9:14,453,262...14,556,352 		JBrowse link
G Ankrd1 ankyrin repeat domain 1 (cardiac muscle) decreases expression
multiple interactions		 ISO
EXP		 verteporfin results in decreased expression of ANKRD1 mRNA
Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ANKRD1 mRNA]
verteporfin inhibits the reaction [YAP1 protein results in increased expression of ANKRD1 mRNA]		 CTD PMID:29725256 PMID:29893953 NCBI chr19:36,089,365...36,097,244
Ensembl chr19:36,089,361...36,097,499 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions EXP Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of BIRC5 mRNA] CTD PMID:29893953 NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569 		JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 multiple interactions EXP Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL2 protein] CTD PMID:31812773 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccl5 chemokine (C-C motif) ligand 5 multiple interactions EXP Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL5 protein] CTD PMID:31812773 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344 		JBrowse link
G Ccn1 cellular communication network factor 1 multiple interactions
decreases expression		 ISO
EXP		 Verteporfin inhibits the reaction [YAP1 protein results in increased expression of CCN1 mRNA]
Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CCN1 mRNA]
Verteporfin results in decreased expression of CCN1 mRNA		 CTD PMID:29725256 PMID:29893953 NCBI chr 3:145,352,726...145,355,740
Ensembl chr 3:145,352,731...145,355,736 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions
decreases expression		 ISO Verteporfin inhibits the reaction [YAP1 protein results in increased expression of CCN2 mRNA]
Verteporfin results in decreased expression of CCN2 mRNA		 CTD PMID:29725256 NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581 		JBrowse link
G Ccna2 cyclin A2 multiple interactions EXP Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CCNA2 mRNA] CTD PMID:29893953 NCBI chr 3:36,619,014...36,627,187
Ensembl chr 3:36,619,014...36,626,299 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions EXP Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CCNB1 mRNA] CTD PMID:29893953 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078 		JBrowse link
G Cma1 chymase 1, mast cell multiple interactions EXP Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CMA1 protein] CTD PMID:31812773 NCBI chr14:56,178,908...56,182,132
Ensembl chr14:56,178,908...56,182,132 		JBrowse link
G Csf3 colony stimulating factor 3 (granulocyte) multiple interactions EXP Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CSF3 protein] CTD PMID:31812773 NCBI chr11:98,591,287...98,594,457
Ensembl chr11:98,592,089...98,594,455 		JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 multiple interactions EXP Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CYP2B10 mRNA] CTD PMID:29893953 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049 		JBrowse link
G Cyp2c55 cytochrome P450, family 2, subfamily c, polypeptide 55 multiple interactions EXP Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CYP2C55 mRNA] CTD PMID:29893953 NCBI chr19:38,995,384...39,031,134
Ensembl chr19:38,995,463...39,031,137 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP verteporfin results in increased expression of HMOX1 protein CTD PMID:16462769 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO		 Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]
[EVP 4593 co-treated with Verteporfin] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]		 CTD PMID:31812773 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Jak1 Janus kinase 1 decreases expression
multiple interactions		 EXP Verteporfin results in decreased expression of JAK1 protein
[Verteporfin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in decreased expression of JAK1 protein		 CTD PMID:31812773 NCBI chr 4:101,009,171...101,122,493
Ensembl chr 4:101,009,564...101,122,479 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions
decreases expression		 EXP [Verteporfin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in decreased expression of JAK2 protein
Verteporfin results in decreased expression of JAK2 protein		 CTD PMID:31812773 NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480 		JBrowse link
G Mcm2 minichromosome maintenance complex component 2 multiple interactions EXP Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of MCM2 mRNA] CTD PMID:29893953 NCBI chr 6:88,860,456...88,875,762
Ensembl chr 6:88,860,456...88,875,762 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO Verteporfin results in increased cleavage of PARP1 protein CTD PMID:31494105 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP [Verteporfin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in decreased expression of RELA protein; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of and results in increased phosphorylation of RELA protein] CTD PMID:31812773 NCBI chr19:5,687,569...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression
multiple interactions		 EXP Verteporfin results in decreased expression of STAT1 protein
Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of and results in increased phosphorylation of STAT1 protein]		 CTD PMID:31812773 NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases expression
multiple interactions		 EXP Verteporfin results in decreased expression of STAT3 protein
Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of and results in increased phosphorylation of STAT3 protein]		 CTD PMID:31812773 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366 		JBrowse link
G Tead1 TEA domain family member 1 multiple interactions EXP Verteporfin inhibits the reaction [YAP1 protein binds to TEAD1 protein] CTD PMID:29893953 NCBI chr 7:112,278,563...112,505,991
Ensembl chr 7:112,278,525...112,506,014 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO		 Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]
[EVP 4593 co-treated with Verteporfin] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]		 CTD PMID:31812773 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Yap1 yes-associated protein 1 multiple interactions
decreases activity
decreases expression		 ISO
EXP		 Verteporfin inhibits the reaction [AMOTL1 protein results in increased activity of YAP1 protein]; Verteporfin inhibits the reaction [YAP1 protein results in increased expression of ANKRD1 mRNA]; Verteporfin inhibits the reaction [YAP1 protein results in increased expression of CCN1 mRNA]; Verteporfin inhibits the reaction [YAP1 protein results in increased expression of CCN2 mRNA]
Verteporfin results in decreased activity of YAP1 protein
Verteporfin results in decreased expression of YAP1 protein
Verteporfin inhibits the reaction [YAP1 protein binds to TEAD1 protein]		 CTD PMID:29725256 PMID:29893953 PMID:31494105 PMID:34351699 PMID:34480788 NCBI chr 9:7,932,000...8,004,890
Ensembl chr 9:7,932,000...8,004,597 		JBrowse link
zinc protoporphyrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions EXP
ISO		 zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]]; zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]]
zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]		 CTD PMID:20052772 PMID:20861358 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) multiple interactions ISO [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [neferine inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]]; [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [neferine inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]] CTD PMID:20523338 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO zinc protoporphyrin inhibits the reaction [olprinone results in increased activity of AKT1 protein] CTD PMID:19387321 NCBI chr12:112,620,255...112,641,318
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Alad aminolevulinate, delta-, dehydratase affects abundance ISO ALAD gene SNP affects the abundance of zinc protoporphyrin CTD PMID:25963508 NCBI chr 4:62,424,221...62,438,300
Ensembl chr 4:62,427,406...62,438,155 		JBrowse link
G Alb albumin multiple interactions EXP
ISO		 ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [Peptidoglycan results in increased expression of NOS2 protein]]; ALB protein inhibits the reaction [zinc protoporphyrin results in increased expression of HMOX1 protein]
zinc protoporphyrin inhibits the reaction [ALB protein results in increased expression of HMOX1 protein]; zinc protoporphyrin promotes the reaction [ALB protein results in increased expression of TIMP1 protein]		 CTD PMID:19376148 PMID:21163135 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Alms1 ALMS1, centrosome and basal body associated multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of ALMS1 mRNA CTD PMID:22839698 NCBI chr 6:85,564,482...85,698,973
Ensembl chr 6:85,564,513...85,679,735 		JBrowse link
G Ap2a1 adaptor-related protein complex 2, alpha 1 subunit multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of AP2A1 mRNA CTD PMID:22839698 NCBI chr 7:44,549,797...44,578,914
Ensembl chr 7:44,549,797...44,578,920 		JBrowse link
G Ap3d1 adaptor-related protein complex 3, delta 1 subunit multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of AP3D1 mRNA CTD PMID:22839698 NCBI chr10:80,542,790...80,578,137
Ensembl chr10:80,542,790...80,578,098 		JBrowse link
G Asf1a anti-silencing function 1A histone chaperone multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of ASF1A mRNA CTD PMID:22839698 NCBI chr10:53,473,057...53,485,321
Ensembl chr10:53,472,853...53,485,321 		JBrowse link
G Bax BCL2-associated X protein multiple interactions EXP
ISO		 zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]]; zinc protoporphyrin inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]
zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]]
zinc protoporphyrin inhibits the reaction [Cisplatin results in increased expression of BAX protein]		 CTD PMID:22763982 PMID:27523796 PMID:27815112 PMID:32621855 NCBI chr 7:45,111,119...45,116,344
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions EXP
ISO		 zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; zinc protoporphyrin inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]
zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]]		 CTD PMID:22763982 PMID:27523796 PMID:32621855 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions
increases expression		 ISO zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of BCL2L1 protein]
zinc protoporphyrin results in increased expression of BCL2L1 protein		 CTD PMID:20357190 PMID:27829220 NCBI chr 2:152,600,652...152,675,723
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Bcl2l11 BCL2-like 11 (apoptosis facilitator) increases expression ISO zinc protoporphyrin results in increased expression of BCL2L11 protein CTD PMID:27829220 NCBI chr 2:127,967,958...128,004,467
Ensembl chr 2:127,967,958...128,004,467 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO zinc protoporphyrin analog inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of BIRC3 protein] CTD PMID:18508827 NCBI chr 9:7,848,698...7,873,199
Ensembl chr 9:7,848,700...7,873,187 		JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha multiple interactions ISO zinc protoporphyrin inhibits the reaction [monophosphoryl lipid A results in increased expression of CALCA mRNA] CTD PMID:11738242 NCBI chr 7:114,225,223...114,236,145
Ensembl chr 7:114,230,713...114,235,592 		JBrowse link
G Cand1 cullin associated and neddylation disassociated 1 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of CAND1 mRNA CTD PMID:22839698 NCBI chr10:119,034,717...119,075,960
Ensembl chr10:119,035,160...119,075,960 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
decreases activity		 EXP
ISO		 zinc protoporphyrin inhibits the reaction [[Glucose deficiency co-treated with Simvastatin] results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [Resveratrol inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]]; zinc protoporphyrin inhibits the reaction [sesamol inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]]; zinc protoporphyrin promotes the reaction [T-2 Toxin results in increased activity of CASP3 protein]
zinc protoporphyrin results in increased cleavage of CASP3 protein
zinc protoporphyrin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased activity of CASP3 protein]]; zinc protoporphyrin inhibits the reaction [FASLG protein results in increased activity of CASP3 protein]; zinc protoporphyrin inhibits the reaction [FASLG protein results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]]; zinc protoporphyrin promotes the reaction [arsenic trioxide results in increased activity of CASP3 protein]; zinc protoporphyrin promotes the reaction [quinocetone results in increased activity of CASP3 protein]
zinc protoporphyrin inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in decreased expression of CASP3 protein]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in increased expression of CASP3 mRNA]]; zinc protoporphyrin promotes the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased cleavage of CASP3 protein]; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased cleavage of CASP3 protein]
zinc protoporphyrin results in decreased activity of CASP3 protein		 CTD PMID:16051694 PMID:17928392 PMID:20357190 PMID:21295052 PMID:22763982 More... NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO zinc protoporphyrin inhibits the reaction [FASLG protein results in increased activity of CASP8 protein] CTD PMID:16051694 NCBI chr 1:58,834,398...58,886,662
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO
EXP		 zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased activity of CASP9 protein]]; zinc protoporphyrin promotes the reaction [quinocetone results in increased activity of CASP9 protein]
zinc protoporphyrin inhibits the reaction [sesamol inhibits the reaction [Lipopolysaccharides results in increased activity of CASP9 protein]]; zinc protoporphyrin promotes the reaction [T-2 Toxin results in increased activity of CASP9 protein]		 CTD PMID:27375190 PMID:29432840 PMID:30261164 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cat catalase multiple interactions ISO zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in decreased expression of CAT protein]] CTD PMID:32621855 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccdc6 coiled-coil domain containing 6 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of CCDC6 mRNA CTD PMID:22839698 NCBI chr10:69,932,709...70,029,030
Ensembl chr10:69,932,951...70,029,030 		JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 multiple interactions ISO zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in decreased expression of CCL2 protein]; zinc protoporphyrin promotes the reaction [Indomethacin results in increased expression of CCL2 mRNA] CTD PMID:20357190 PMID:23892052 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccr7 chemokine (C-C motif) receptor 7 multiple interactions EXP zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of CCR7 mRNA] CTD PMID:33049506 NCBI chr11:99,035,025...99,045,903
Ensembl chr11:99,035,022...99,045,903 		JBrowse link
G Cd40 CD40 antigen multiple interactions EXP zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA] CTD PMID:33049506 NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868 		JBrowse link
G Cd80 CD80 antigen multiple interactions EXP zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 mRNA] CTD PMID:33049506 NCBI chr16:38,277,793...38,316,682
Ensembl chr16:38,275,923...38,316,697 		JBrowse link
G Cd83 CD83 antigen multiple interactions EXP zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of CD83 mRNA] CTD PMID:33049506 NCBI chr13:43,938,588...43,956,609
Ensembl chr13:43,938,251...43,956,608 		JBrowse link
G Cd86 CD86 antigen multiple interactions EXP zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 mRNA] CTD PMID:33049506 NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443 		JBrowse link
G Cdk13 cyclin-dependent kinase 13 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of CDK13 mRNA CTD PMID:22839698 NCBI chr13:17,885,309...17,979,960
Ensembl chr13:17,884,900...17,979,682 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) multiple interactions ISO zinc protoporphyrin analog inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of and affects the localization of CDKN1A protein] CTD PMID:18508827 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Chd7 chromodomain helicase DNA binding protein 7 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of CHD7 mRNA CTD PMID:22839698 NCBI chr 4:8,690,345...8,868,449
Ensembl chr 4:8,690,406...8,867,659 		JBrowse link
G Cmbl carboxymethylenebutenolidase-like (Pseudomonas) multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of CMBL mRNA CTD PMID:22839698 NCBI chr15:31,565,314...31,590,266
Ensembl chr15:31,565,535...31,590,265 		JBrowse link
G Cxcl1 chemokine (C-X-C motif) ligand 1 increases expression ISO zinc protoporphyrin results in increased expression of CXCL1 mRNA CTD PMID:25780291 NCBI chr 5:91,039,104...91,040,980
Ensembl chr 5:91,039,100...91,040,974 		JBrowse link
G Cxcl10 chemokine (C-X-C motif) ligand 10 multiple interactions EXP zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]] CTD PMID:20861358 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748 		JBrowse link
G Cxcl2 chemokine (C-X-C motif) ligand 2 increases expression ISO zinc protoporphyrin results in increased expression of CXCL2 mRNA CTD PMID:25780291 NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of CYP1A1 protein CTD PMID:26747958 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of CYP1A2 protein CTD PMID:26747958 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp2a5 cytochrome P450, family 2, subfamily a, polypeptide 5 multiple interactions EXP [zinc protoporphyrin co-treated with Hemin] results in increased expression of CYP2A5 mRNA CTD PMID:22859313 NCBI chr 7:26,534,764...26,542,689
Ensembl chr 7:26,534,730...26,542,973 		JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 multiple interactions ISO [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of CYP2B1 protein CTD PMID:26747958 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of CYP2E1 mRNA; [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of CYP2E1 protein; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 mRNA]; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 protein]
zinc protoporphyrin inhibits the reaction [Quercetin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]]; zinc protoporphyrin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer inhibits the reaction [Ethanol results in increased activity of CYP2E1 protein]]		 CTD PMID:19325051 PMID:26747958 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Dcun1d1 DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae) multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of DCUN1D1 mRNA CTD PMID:22839698 NCBI chr 3:35,946,254...35,991,626
Ensembl chr 3:35,946,254...35,991,594 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO zinc protoporphyrin promotes the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of DDIT3 protein]; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of DDIT3 protein] CTD PMID:26747958 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157 		JBrowse link
G Dhx29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of DHX29 mRNA CTD PMID:22839698 NCBI chr13:113,063,976...113,105,968
Ensembl chr13:113,063,988...113,105,966 		JBrowse link
G Dusp10 dual specificity phosphatase 10 multiple interactions ISO zinc protoporphyrin inhibits the reaction [andrographolide results in increased expression of DUSP10 mRNA]; zinc protoporphyrin inhibits the reaction [andrographolide results in increased expression of DUSP10 protein] CTD PMID:29165873 NCBI chr 1:183,766,575...183,807,833
Ensembl chr 1:183,745,499...183,807,833 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO zinc protoporphyrin promotes the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased phosphorylation of EIF2AK3 protein]; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased phosphorylation of EIF2AK3 protein] CTD PMID:26747958 NCBI chr 6:70,821,468...70,882,225
Ensembl chr 6:70,821,499...70,882,229 		JBrowse link
G Eml4 echinoderm microtubule associated protein like 4 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of EML4 mRNA CTD PMID:22839698 NCBI chr17:83,658,341...83,787,790
Ensembl chr17:83,658,360...83,787,790 		JBrowse link
G F2 coagulation factor II multiple interactions ISO zinc protoporphyrin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer inhibits the reaction [F2 protein results in increased expression of PTGS2 protein]]; zinc protoporphyrin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer inhibits the reaction [F2 protein results in increased secretion of Dinoprostone]] CTD PMID:26385185 NCBI chr 2:91,442,742...91,466,802
Ensembl chr 2:91,455,665...91,466,759 		JBrowse link
G Fasl Fas ligand (TNF superfamily, member 6) multiple interactions ISO zinc protoporphyrin inhibits the reaction [FASLG protein results in increased activity of CASP3 protein]; zinc protoporphyrin inhibits the reaction [FASLG protein results in increased activity of CASP8 protein]; zinc protoporphyrin inhibits the reaction [FASLG protein results in increased cleavage of CASP3 protein] CTD PMID:16051694 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064 		JBrowse link
G Fbxw13 F-box and WD-40 domain protein 13 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of FBXW12 mRNA CTD PMID:22839698 NCBI chr 9:109,008,295...109,025,043
Ensembl chr 9:109,008,295...109,025,043 		JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of FGFR1 mRNA CTD PMID:22839698 NCBI chr 8:26,008,775...26,065,734
Ensembl chr 8:26,003,670...26,065,734 		JBrowse link
G Flt1 FMS-like tyrosine kinase 1 multiple interactions ISO zinc protoporphyrin inhibits the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]] CTD PMID:25371888 NCBI chr 5:147,498,414...147,663,419
Ensembl chr 5:147,498,414...147,662,821 		JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression ISO zinc protoporphyrin results in increased expression of FOS mRNA CTD PMID:10381381 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Fut4 fucosyltransferase 4 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of FUT4 mRNA CTD PMID:22839698 NCBI chr 9:14,659,755...14,663,418
Ensembl chr 9:14,659,616...14,663,689 		JBrowse link
G Glul glutamate-ammonia ligase (glutamine synthetase) multiple interactions ISO zinc protoporphyrin inhibits the reaction [resveratrol inhibits the reaction [Ammonia results in decreased activity of GLUL protein]]; zinc protoporphyrin inhibits the reaction [resveratrol results in increased activity of GLUL protein] CTD PMID:26318273 NCBI chr 1:153,775,675...153,785,469
Ensembl chr 1:153,775,690...153,785,469 		JBrowse link
G Gm9920 predicted gene 9920 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of FAM106A mRNA CTD PMID:22839698 NCBI chr15:54,963,313...54,976,978
Ensembl chr15:54,963,313...54,977,073 		JBrowse link
G Gpr132 G protein-coupled receptor 132 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of GPR132 mRNA CTD PMID:22839698 NCBI chr12:112,814,493...112,832,035
Ensembl chr12:112,814,493...112,831,848 		JBrowse link
G Gucy1a1 guanylate cyclase 1, soluble, alpha 1 multiple interactions ISO zinc protoporphyrin inhibits the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]] CTD PMID:19466990 NCBI chr 3:81,999,734...82,053,253
Ensembl chr 3:81,999,734...82,053,096 		JBrowse link
G Gucy1b1 guanylate cyclase 1, soluble, beta 1 multiple interactions ISO zinc protoporphyrin inhibits the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]] CTD PMID:19466990 NCBI chr 3:81,939,311...81,982,018
Ensembl chr 3:81,939,313...81,981,996 		JBrowse link
G Haus2 HAUS augmin-like complex, subunit 2 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of HAUS2 mRNA CTD PMID:22839698 NCBI chr 2:120,439,863...120,452,041
Ensembl chr 2:120,439,864...120,452,041 		JBrowse link
G Hfe homeostatic iron regulator affects abundance ISO HFE gene polymorphism affects the abundance of zinc protoporphyrin CTD PMID:25963508 NCBI chr13:23,886,017...23,894,837
Ensembl chr13:23,886,017...23,894,837 		JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions ISO zinc protoporphyrin inhibits the reaction [HIF1A protein results in increased activity of SOD2 protein] CTD PMID:17066447 NCBI chr12:73,948,098...73,994,328
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO
EXP		 zinc protoporphyrin promotes the reaction [lead acetate results in increased expression of HMGB1 mRNA]
zinc protoporphyrin inhibits the reaction [sesamol inhibits the reaction [Lipopolysaccharides results in increased expression of HMGB1 protein]]		 CTD PMID:29447957 PMID:30261164 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases expression
increases expression
affects expression
decreases activity		 ISO
EXP		 [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [cobaltiprotoporphyrin results in increased expression of TP53 protein]; [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [neferine inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]]; [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [neferine inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]]; [zinc protoporphyrin results in decreased activity of HMOX1 protein] which results in increased susceptibility to 2-butenal; [zinc protoporphyrin results in decreased activity of HMOX1 protein] which results in increased susceptibility to arsenic trioxide; [zinc protoporphyrin results in decreased activity of HMOX1] which results in decreased susceptibility to peoniflorin; zinc protoporphyrin analog inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron]; zinc protoporphyrin inhibits the reaction [[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in decreased abundance of Glutathione]]; zinc protoporphyrin inhibits the reaction [[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in increased abundance of Malondialdehyde]]; zinc protoporphyrin inhibits the reaction [[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] which results in decreased susceptibility to Ethanol]; zinc protoporphyrin inhibits the reaction [ALB protein results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [cilostazol results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [cilostazol results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased activity of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased expression of IL6 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]]; zinc protoporphyrin promotes the reaction [arsenic trioxide results in increased expression of HMOX1 protein]; zinc protoporphyrin results in decreased expression of and results in decreased activity of HMOX1 protein; zinc protoporphyrin results in increased expression of and results in decreased activity of HMOX1 protein
zinc protoporphyrin results in decreased expression of HMOX1 mRNA; zinc protoporphyrin results in decreased expression of HMOX1 protein
zinc protoporphyrin results in increased expression of HMOX1 protein
zinc protoporphyrin affects the expression of HMOX1 mRNA; zinc protoporphyrin affects the expression of HMOX1 protein
zinc protoporphyrin results in decreased activity of HMOX1; zinc protoporphyrin results in decreased activity of HMOX1 protein
zinc protoporphyrin results in increased expression of HMOX1 mRNA; zinc protoporphyrin results in increased expression of HMOX1 protein
[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of HMOX1 mRNA; [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with zinc protoporphyrin] results in increased expression of HMOX1 mRNA; [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]; [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [Resveratrol results in increased abundance of Glutathione]; [zinc protoporphyrin results in decreased activity of HMOX1 protein] which results in decreased susceptibility to Resveratrol; Hemin inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]]; Hemin inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Glucose results in decreased activity of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin promotes the reaction [Glucose results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Hemin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]]; zinc protoporphyrin inhibits the reaction [Hemin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides]; zinc protoporphyrin inhibits the reaction [lead acetate results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [olprinone results in increased activity of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Propofol inhibits the reaction [Glucose results in decreased activity of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Propofol promotes the reaction [Glucose results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Sildenafil Citrate results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [Sildenafil Citrate results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Tadalafil promotes the reaction [Cisplatin results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of HMOX1 protein]
[zinc protoporphyrin co-treated with Hemin] results in increased expression of HMOX1 mRNA; [zinc protoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; ALB protein inhibits the reaction [zinc protoporphyrin results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [[Lipopolysaccharides co-treated with 2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone] results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Cisplatin results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Glucose deficiency promotes the reaction [Simvastatin results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides]; zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Resveratrol inhibits the reaction [Doxorubicin results in decreased expression of and results in decreased activity of HMOX1 protein]]		 CTD PMID:7524564 PMID:12352873 PMID:14649057 PMID:15602829 PMID:16462769 More... NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hmox2 heme oxygenase 2 decreases activity
decreases expression		 EXP
ISO		 zinc protoporphyrin results in decreased activity of HMOX2 protein
zinc protoporphyrin results in decreased expression of HMOX2 protein		 CTD PMID:21448202 PMID:25824035 NCBI chr16:4,544,225...4,584,606
Ensembl chr16:4,544,225...4,584,606 		JBrowse link
G Hp1bp3 heterochromatin protein 1, binding protein 3 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of HP1BP3 mRNA CTD PMID:22839698 NCBI chr 4:137,938,789...137,971,994
Ensembl chr 4:137,943,607...137,971,994 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 multiple interactions EXP zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased expression of HSD11B1 mRNA]] CTD PMID:27523796 NCBI chr 1:192,903,948...192,946,353
Ensembl chr 1:192,903,942...192,946,383 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO
EXP		 zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]
zinc protoporphyrin promotes the reaction [Indomethacin results in increased expression of ICAM1 mRNA]
zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]		 CTD PMID:19608869 PMID:23892052 PMID:33049506 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Ifnb1 interferon beta 1, fibroblast multiple interactions EXP zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]] CTD PMID:20861358 NCBI chr 4:88,440,262...88,441,031
Ensembl chr 4:88,440,262...88,441,011 		JBrowse link
G Ifng interferon gamma multiple interactions
increases expression		 ISO zinc protoporphyrin inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased expression of HMOX1 protein]
zinc protoporphyrin results in increased expression of IFNG mRNA		 CTD PMID:21295052 PMID:25780291 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of IL10 mRNA]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of IL10 protein] CTD PMID:20056245 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il12b interleukin 12b multiple interactions EXP zinc protoporphyrin promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA]]