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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:monohydroxy-5beta-cholanic acid
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Accession:CHEBI:36260 term browser browse the term
Synonyms:related_synonym: monohydroxy-5beta-cholanic acids


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7-oxolithocholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 increases reduction
multiple interactions
ISO HSD11B1 protein results in increased reduction of 7-ketolithocholic acid
[HSD11B1 protein results in increased reduction of 7-ketolithocholic acid] which results in increased chemical synthesis of Chenodeoxycholic Acid; [HSD11B1 protein results in increased reduction of 7-ketolithocholic acid] which results in increased chemical synthesis of Ursodeoxycholic Acid
CTD PMID:21453287 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
JBrowse link
glycolithocholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases abundance ISO HSD11B1 gene mutant form results in decreased abundance of glycolithocholic acid CTD PMID:25061560 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
JBrowse link
G Por cytochrome p450 oxidoreductase increases abundance ISO POR gene mutant form results in increased abundance of glycolithocholic acid CTD PMID:25034404 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
lithocholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 decreases expression
increases expression
multiple interactions
ISO Lithocholic Acid results in decreased expression of ABCA1 mRNA; Lithocholic Acid results in decreased expression of ABCA1 protein
Lithocholic Acid results in increased expression of ABCA1 mRNA
NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCA1 mRNA]
CTD PMID:15883047, PMID:20977460 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 increases expression
decreases expression
multiple interactions
ISO Lithocholic Acid results in increased expression of ABCB11 mRNA
Lithocholic Acid results in decreased expression of ABCB11 mRNA
Lithocholic Acid promotes the reaction [NR1H3 protein results in increased expression of ABCB11 mRNA]
[Lithocholic Acid analog binds to and results in increased activity of NR1H4 protein] which results in increased expression of ABCB11 mRNA; [Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of ABCB11 mRNA
CTD PMID:17256725, PMID:17963371, PMID:20359477, PMID:20977460, PMID:23034213, PMID:25055961, PMID:25582706 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
multiple interactions
ISO Lithocholic Acid results in increased expression of ABCB1 mRNA
VDR protein promotes the reaction [Lithocholic Acid results in increased expression of ABCB1 mRNA]
CTD PMID:19460946 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B increases expression ISO Lithocholic Acid results in increased expression of ABCB1B mRNA CTD PMID:20977460 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 increases expression ISO Lithocholic Acid results in increased expression of ABCB4 mRNA CTD PMID:20359477, PMID:25582706 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression
multiple interactions
ISO Lithocholic Acid results in increased expression of ABCC1 mRNA; Lithocholic Acid results in increased expression of ABCC1 protein
Lithocholic Acid inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]
[Lithocholic Acid co-treated with oltipraz] results in increased expression of ABCC1 protein; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC1 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC1 mRNA]
CTD PMID:16101123, PMID:18032408, PMID:20977460, PMID:23034213 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression
affects localization
multiple interactions
ISO
EXP
Lithocholic Acid results in increased expression of ABCC2 mRNA
Lithocholic Acid results in increased expression of ABCC2 mRNA; Lithocholic Acid results in increased expression of ABCC2 protein
Lithocholic Acid affects the localization of ABCC2 protein
[Cyclosporine results in decreased activity of ABCC2 protein] which results in increased abundance of Lithocholic Acid; [Lithocholic Acid results in increased activity of NR1I2 protein] which results in increased expression of ABCC2 mRNA
[Lithocholic Acid binds to and results in increased activity of NR1I2 protein] which results in increased expression of ABCC2 mRNA
[Lithocholic Acid co-treated with oltipraz] results in increased expression of ABCC2 protein; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC2 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC2 protein]
CTD PMID:14570758, PMID:16436656, PMID:18032408, PMID:20888898, PMID:20977460, PMID:21311750, PMID:25582706, PMID:26198044 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions
decreases expression
increases expression
increases activity
ISO [Lithocholic Acid co-treated with 1,4-bis(2-(3,5-dichloropyridyloxy))benzene] results in increased expression of ABCC3 mRNA; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC3 mRNA]; NR1I3 protein affects the reaction [Lithocholic Acid results in increased expression of ABCC3 mRNA]
Lithocholic Acid results in decreased expression of ABCC3 mRNA
Lithocholic Acid results in increased activity of ABCC3 protein
[Lithocholic Acid results in increased activity of NR1I2 protein] which results in increased expression of ABCC3 mRNA
Lithocholic Acid results in increased expression of ABCC3 mRNA; Lithocholic Acid results in increased expression of ABCC3 protein
CTD PMID:14570758, PMID:15358766, PMID:15824121, PMID:16436656, PMID:18032408, PMID:20888898, PMID:20977460, PMID:25055961, PMID:25582706 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases expression
decreases expression
multiple interactions
ISO Lithocholic Acid results in increased expression of ABCC4 mRNA
Lithocholic Acid results in decreased expression of ABCC4 mRNA
1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [Lithocholic Acid results in increased expression of ABCC4 mRNA]; [Lithocholic Acid co-treated with 1,4-bis(2-(3,5-dichloropyridyloxy))benzene] results in increased expression of ABCC4 protein; [Lithocholic Acid co-treated with oltipraz] results in increased expression of ABCC4 protein; Lithocholic Acid promotes the reaction [NR1H3 protein results in increased expression of ABCC4 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC4 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC4 mRNA]
CTD PMID:17256725, PMID:18032408, PMID:20977460, PMID:23034213 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 multiple interactions
increases expression
ISO [Lithocholic Acid co-treated with oltipraz] results in increased expression of ABCC5 protein; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC5 mRNA]
Lithocholic Acid results in increased expression of ABCC5 mRNA; Lithocholic Acid results in increased expression of ABCC5 protein
CTD PMID:18032408, PMID:20977460, PMID:23034213 NCBI chr11:84,395,982...84,490,215
Ensembl chr11:84,396,033...84,490,211
JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 decreases expression ISO Lithocholic Acid results in decreased expression of ABCC6 protein CTD PMID:18032408 NCBI chr 1:101,954,786...102,013,252
Ensembl chr 1:101,959,540...102,013,243
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases expression
ISO NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCG2 mRNA] CTD PMID:20977460 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 multiple interactions
increases expression
ISO [Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in increased expression of ABCG5 mRNA
Lithocholic Acid results in increased expression of ABCG5 mRNA
CTD PMID:20359477, PMID:25055961, PMID:25582706 NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 decreases expression
increases expression
ISO Lithocholic Acid results in decreased expression of ABCG8 mRNA
Lithocholic Acid results in increased expression of ABCG8 mRNA
CTD PMID:20359477, PMID:25582706 NCBI chr 6:7,961,413...7,980,708
Ensembl chr 6:7,961,413...7,980,708
JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions
decreases expression
ISO Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of ACACA mRNA] CTD PMID:20359477 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Acadvl acyl-CoA dehydrogenase, very long chain decreases expression ISO Lithocholic Acid results in decreased expression of ACADVL mRNA CTD PMID:20359477 NCBI chr10:56,619,321...56,624,468
Ensembl chr10:56,619,303...56,624,526
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression
multiple interactions
ISO Lithocholic Acid results in decreased expression of ACSL1 mRNA
Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of ACSL1 mRNA]
CTD PMID:20359477 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
decreases abundance
increases secretion
ISO AHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in decreased secretion of Lithocholic Acid]
AHR gene mutant form results in decreased abundance of Lithocholic Acid
AHR gene mutant form results in increased secretion of Lithocholic Acid
CTD PMID:29452137, PMID:32679164 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 affects binding
decreases activity
ISO AKR1C2 protein binds to Lithocholic Acid; Lithocholic Acid binds to AKR1C2 protein
Lithocholic Acid results in decreased activity of AKR1C2 protein
CTD PMID:8486699, PMID:8573067, PMID:12604236 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Lithocholic Acid results in decreased activity of AKR1C3 protein CTD PMID:12604236, PMID:21851338 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Alb albumin affects binding ISO Lithocholic Acid analog binds to ALB protein CTD PMID:19900495 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO [Lithocholic Acid co-treated with lysophosphatidic acid] results in increased activity of ALPL protein; EGF protein promotes the reaction [Lithocholic Acid results in increased activity of ALPL protein] CTD PMID:19646460 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Anxa1 annexin A1 increases expression ISO Lithocholic Acid results in increased expression of ANXA1 mRNA CTD PMID:20359477 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
JBrowse link
G Anxa2 annexin A2 multiple interactions
increases expression
ISO Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased expression of ANXA2 mRNA] CTD PMID:20359477 NCBI chr 8:75,687,134...75,723,589
Ensembl chr 8:75,687,100...75,723,594
JBrowse link
G Anxa3 annexin A3 increases expression
multiple interactions
ISO Lithocholic Acid results in increased expression of ANXA3 mRNA
Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased expression of ANXA3 mRNA]
CTD PMID:20359477 NCBI chr14:14,371,921...14,426,503
Ensembl chr14:14,364,008...14,426,437
JBrowse link
G Anxa4 annexin A4 multiple interactions
increases expression
ISO Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased expression of ANXA4 mRNA] CTD PMID:20359477 NCBI chr 4:118,538,775...118,595,591
Ensembl chr 4:118,538,777...118,595,580
JBrowse link
G Anxa5 annexin A5 increases expression
multiple interactions
ISO Lithocholic Acid results in increased expression of ANXA5 mRNA
Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased expression of ANXA5 mRNA]
CTD PMID:20359477 NCBI chr 2:123,162,477...123,194,730
Ensembl chr 2:123,162,461...123,193,130
JBrowse link
G Apoa4 apolipoprotein A4 increases expression ISO Lithocholic Acid results in increased expression of APOA4 mRNA CTD PMID:20359477 NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376
JBrowse link
G Apoc1 apolipoprotein C1 decreases expression ISO Lithocholic Acid results in decreased expression of APOC1 mRNA CTD PMID:20359477 NCBI chr 1:80,606,638...80,609,921
Ensembl chr 1:80,606,638...80,609,921
JBrowse link
G Apoc2 apolipoprotein C2 increases expression ISO Lithocholic Acid results in increased expression of APOC2 mRNA CTD PMID:20359477 NCBI chr 1:80,589,023...80,593,991
Ensembl chr 1:80,589,023...80,594,136
JBrowse link
G Apoc4 apolipoprotein C4 decreases expression ISO Lithocholic Acid results in decreased expression of APOC4 mRNA CTD PMID:20359477 NCBI chr 1:80,595,339...80,599,525
Ensembl chr 1:80,595,326...80,599,572
JBrowse link
G Ar androgen receptor multiple interactions
affects binding
ISO Lithocholic Acid inhibits the reaction [Dihydrotestosterone binds to AR protein]
Lithocholic Acid binds to AR protein
CTD PMID:15206167 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Baat bile acid CoA:amino acid N-acyltransferase decreases expression
multiple interactions
ISO Lithocholic Acid results in decreased expression of BAAT mRNA
1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of BAAT mRNA]; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of BAAT mRNA]]; NR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of BAAT mRNA]]; Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of BAAT mRNA]
CTD PMID:19196849 NCBI chr 5:64,768,397...64,777,368
Ensembl chr 5:64,768,401...64,777,368
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO [Lithocholic Acid co-treated with 1,4-bis(2-(3,5-dichloropyridyloxy))benzene] results in decreased expression of BAK1 protein; [Lithocholic Acid co-treated with Phenobarbital] results in decreased expression of BAK1 protein; [Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of BAK1 protein CTD PMID:19433268 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
EXP
ISO
Lithocholic Acid results in increased expression of BAX mRNA
[Lithocholic Acid co-treated with 1,4-bis(2-(3,5-dichloropyridyloxy))benzene] results in decreased expression of BAX protein; [Lithocholic Acid co-treated with 1,4-bis(2-(3,5-dichloropyridyloxy))benzene] results in increased expression of BAX mRNA; [Lithocholic Acid co-treated with oltipraz] results in increased expression of BAX mRNA; [Lithocholic Acid co-treated with Phenobarbital] results in decreased expression of BAX protein; [Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of BAX protein; Phenobarbital inhibits the reaction [Lithocholic Acid results in increased expression of BAX mRNA]
CTD PMID:17881359, PMID:19433268 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
increases expression
ISO 1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in increased expression of BCL2L1 mRNA]; [Lithocholic Acid co-treated with oltipraz] results in increased expression of BCL2L1 mRNA; Phenobarbital inhibits the reaction [Lithocholic Acid results in increased expression of BCL2L1 mRNA]; Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased expression of BCL2L1 mRNA] CTD PMID:19433268 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions
increases expression
ISO Lithocholic Acid inhibits the reaction [Vitamin D results in increased expression of BGLAP mRNA]
Lithocholic Acid results in increased expression of BGLAP mRNA
CTD PMID:20055894 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
increases cleavage
ISO [[[[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein] which results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein; [[[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein] which results in increased activity of CASP9 protein; [[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Lithocholic Acid results in increased cleavage of and results in increased activity of BID protein]
Lithocholic Acid results in increased cleavage of BID protein
CTD PMID:19054763 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Brca2 BRCA2, DNA repair associated decreases response to substance ISO BRCA2 protein results in decreased susceptibility to Lithocholic Acid CTD PMID:20028873 NCBI chr12:503,660...544,754
Ensembl chr12:504,007...544,748
JBrowse link
G Calr calreticulin affects expression EXP Lithocholic Acid affects the expression of CALR mRNA CTD PMID:18246545 NCBI chr19:25,956,771...25,961,666
Ensembl chr19:25,956,771...25,961,666
JBrowse link
G Camp cathelicidin antimicrobial peptide multiple interactions
increases expression
ISO [Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of CAMP mRNA; HR protein promotes the reaction [Lithocholic Acid results in increased expression of CAMP mRNA]
Lithocholic Acid analog results in increased expression of CAMP mRNA; Lithocholic Acid results in increased expression of CAMP mRNA; Lithocholic Acid results in increased expression of CAMP protein
CTD PMID:18180267, PMID:19733911, PMID:22466564 NCBI chr 8:117,930,557...117,932,371
Ensembl chr 8:117,930,546...117,932,518
JBrowse link
G Casp1 caspase 1 increases expression
multiple interactions
ISO Lithocholic Acid results in increased expression of CASP1 mRNA; Lithocholic Acid results in increased expression of CASP1 protein
Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in increased expression of CASP1 mRNA]; Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in increased expression of CASP1 protein]
CTD PMID:29794447 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp2 caspase 2 multiple interactions ISO benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Lithocholic Acid results in increased cleavage of and results in increased activity of CASP2 protein]; Lithocholic Acid results in increased cleavage of and results in increased activity of CASP2 protein CTD PMID:19054763 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
increases expression
ISO Lithocholic Acid results in increased cleavage of CASP3 protein
[[[[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein] which results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Lithocholic Acid results in increased cleavage of and results in increased activity of CASP3 protein]; Lithocholic Acid results in increased cleavage of and results in increased activity of CASP3 protein; TNF protein promotes the reaction [Lithocholic Acid results in increased expression of CASP3 protein]
1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in increased cleavage of CASP3 protein]; Phenobarbital inhibits the reaction [Lithocholic Acid results in increased cleavage of CASP3 protein]; Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased cleavage of CASP3 protein]
CTD PMID:19054763, PMID:19433268, PMID:23627780 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [[[[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein] which results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein; [[[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein] which results in increased activity of CASP9 protein; [[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein; [[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Lithocholic Acid results in increased cleavage of and results in increased activity of CASP8 protein]; Lithocholic Acid results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:19054763 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions ISO [[[[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein] which results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein; [[[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein] which results in increased activity of CASP9 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Lithocholic Acid results in increased cleavage of and results in increased activity of CASP9 protein]; Lithocholic Acid results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:19054763 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cav1 caveolin 1 multiple interactions ISO Lithocholic Acid results in increased localization of [VDR protein co-treated with CAV1 protein] CTD PMID:20371703 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Ccnb1 cyclin B1 increases expression ISO Lithocholic Acid results in increased expression of CCNB1 mRNA CTD PMID:19000923 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Cct6a chaperonin containing TCP1 subunit 6A decreases expression ISO Lithocholic Acid results in decreased expression of CCT6A protein CTD PMID:21224350 NCBI chr12:30,491,584...30,501,813
Ensembl chr12:30,491,416...30,501,860
JBrowse link
G Cd14 CD14 molecule increases expression
multiple interactions
ISO Lithocholic Acid analog results in increased expression of CD14 mRNA; Lithocholic Acid results in increased expression of CD14 mRNA
Benzo(a)pyrene promotes the reaction [Lithocholic Acid results in increased expression of CD14 mRNA]
CTD PMID:18180267, PMID:19244278 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO [Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of CDH1 mRNA; Lithocholic Acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of CDH1 protein]]; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of and affects the localization of CDH1 protein]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of CDH1 protein]] CTD PMID:15489543, PMID:31472180 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cers1 ceramide synthase 1 increases expression ISO Lithocholic Acid results in increased expression of CERS1 mRNA CTD PMID:21480330 NCBI chr16:20,845,580...20,860,789
Ensembl chr16:20,845,576...20,860,789
JBrowse link
G Cers2 ceramide synthase 2 increases expression ISO Lithocholic Acid results in increased expression of CERS2 mRNA CTD PMID:21480330 NCBI chr 2:196,487,656...196,495,930
Ensembl chr 2:196,487,656...196,496,986
JBrowse link
G Ces1d carboxylesterase 1D decreases expression
multiple interactions
ISO Lithocholic Acid results in decreased expression of CES1D mRNA
Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of CES1D mRNA]
CTD PMID:20359477 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Cfl1 cofilin 1 increases expression ISO Lithocholic Acid results in increased expression of CFL1 protein CTD PMID:21224350 NCBI chr 1:220,869,805...220,873,337
Ensembl chr 1:220,869,805...220,873,337
JBrowse link
G Chka choline kinase alpha increases expression
multiple interactions
ISO Lithocholic Acid results in increased expression of CHKA mRNA
SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of CHKA mRNA]
CTD PMID:21480330, PMID:23034213 NCBI chr 1:219,076,618...219,126,221
Ensembl chr 1:219,077,771...219,126,220
JBrowse link
G Chpt1 choline phosphotransferase 1 multiple interactions
decreases expression
ISO [Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of CHPT1 mRNA
Lithocholic Acid results in decreased expression of CHPT1 mRNA
CTD PMID:20359477, PMID:21480330 NCBI chr 7:29,019,518...29,070,928
Ensembl chr 7:29,043,916...29,070,928
JBrowse link
G Cldn1 claudin 1 multiple interactions ISO Lithocholic Acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of CLDN1 protein]]; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of and affects the localization of CLDN1 protein]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of CLDN1 protein]] CTD PMID:31472180 NCBI chr11:77,815,216...77,830,373
Ensembl chr11:77,815,181...77,830,416
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO Lithocholic Acid results in increased expression of COL1A1 mRNA CTD PMID:16436656 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 decreases expression ISO Lithocholic Acid results in decreased expression of CPT2 mRNA CTD PMID:20359477 NCBI chr 5:127,505,646...127,523,016
Ensembl chr 5:127,505,614...127,523,089
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO [PPARA protein co-treated with CREB1 protein] promotes the reaction [Lithocholic Acid results in increased expression of PTGS2 mRNA] CTD PMID:18648741 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crot carnitine O-octanoyltransferase multiple interactions
decreases expression
ISO Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of CROT mRNA] CTD PMID:20359477 NCBI chr 4:22,079,837...22,116,265
Ensembl chr 4:22,081,604...22,116,265
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO [Lithocholic Acid binds to VDR protein] which results in decreased activity of CTNNB1 mRNA CTD PMID:20043299 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO Lithocholic Acid results in increased expression of CXCL2 mRNA CTD PMID:24742700 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Lithocholic Acid results in decreased activity of CYP1A1 protein CTD PMID:18420780 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
increases metabolic processing
multiple interactions
ISO
EXP
Lithocholic Acid results in decreased activity of CYP1A2 protein
CYP1A2 protein results in increased metabolism of Lithocholic Acid
[CYP1A2 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of Lithocholic Acid analog
CTD PMID:18039809, PMID:18420780 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Lithocholic Acid results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO
EXP
[Lithocholic Acid analog binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA; [Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA; Benzo(a)pyrene promotes the reaction [Lithocholic Acid results in increased expression of CYP24A1 mRNA]; HR protein inhibits the reaction [Lithocholic Acid results in increased expression of CYP24A1 mRNA]; Lithocholic Acid inhibits the reaction [NCOR2 protein binds to CYP24A1 promoter]; Lithocholic Acid inhibits the reaction [Vitamin D results in increased expression of CYP24A1 mRNA]; Lithocholic Acid promotes the reaction [VDR protein binds to CYP24A1 promoter]
Lithocholic Acid analog results in increased expression of CYP24A1 mRNA; Lithocholic Acid results in increased expression of CYP24A1 mRNA
[Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA; Vitamin D inhibits the reaction [Lithocholic Acid results in increased expression of CYP24A1 mRNA]
CTD PMID:15489543, PMID:17535892, PMID:18180267, PMID:19244278, PMID:20055894, PMID:21311750, PMID:21917910, PMID:22466564 NCBI chr 3:168,097,484...168,111,920
Ensembl chr 3:168,097,485...168,111,920
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO Lithocholic Acid results in increased expression of CYP26A1 mRNA
Lithocholic Acid promotes the reaction [Tretinoin results in increased expression of CYP26A1 mRNA]
CTD PMID:18059332 NCBI chr 1:256,382,861...256,386,729
Ensembl chr 1:256,382,791...256,386,729
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 multiple interactions
decreases expression
ISO 1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP27A1 mRNA]; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP27A1 mRNA]]; NR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of CYP27A1 mRNA]]; Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of CYP27A1 mRNA] CTD PMID:19196849, PMID:20359477 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 decreases activity EXP Lithocholic Acid results in decreased activity of CYP2A1 protein CTD PMID:8889968 NCBI chr 1:83,711,223...83,725,222
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression
decreases activity
multiple interactions
ISO Lithocholic Acid results in increased expression of CYP2B10 mRNA
Lithocholic Acid results in decreased activity of CYP2B10 protein
[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Lithocholic Acid] results in increased expression of CYP2B10 mRNA; [Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in increased expression of CYP2B10 mRNA; [Pregnenolone Carbonitrile co-treated with Lithocholic Acid] results in increased expression of CYP2B10 mRNA; NR1I3 protein affects the reaction [Lithocholic Acid results in increased expression of CYP2B10 mRNA]; NR1I3 protein promotes the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Lithocholic Acid] results in increased expression of CYP2B10 mRNA]; NR1I3 protein promotes the reaction [[Pregnenolone Carbonitrile co-treated with Lithocholic Acid] results in increased expression of CYP2B10 mRNA]
CTD PMID:15358766, PMID:18420780, PMID:19433268, PMID:20359477 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases metabolic processing
decreases activity
multiple interactions
EXP CYP2C11 protein results in increased metabolism of Lithocholic Acid
Lithocholic Acid results in decreased activity of CYP2C11 protein
[CYP2C11 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of 3-oxocholan-24-oic acid
CTD PMID:8889968, PMID:18039809 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp2c22 cytochrome P450, family 2, subfamily c, polypeptide 22 increases expression EXP Lithocholic Acid results in increased expression of CYP2C22 mRNA CTD PMID:21311750 NCBI chr 1:259,257,658...259,297,270
Ensembl chr 1:259,257,657...259,287,684
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases metabolic processing
multiple interactions
EXP CYP2C6V1 protein results in increased metabolism of Lithocholic Acid
[CYP2C6V1 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of Lithocholic Acid analog
CTD PMID:18039809 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Lithocholic Acid results in decreased activity of CYP2C29 protein CTD PMID:18420780 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d1 cytochrome P450, family 2, subfamily d, polypeptide 1 multiple interactions
increases metabolic processing
EXP [CYP2D1 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of Lithocholic Acid analog CTD PMID:18039809 NCBI chr 7:123,625,641...123,630,045
Ensembl chr 7:123,625,590...123,638,765
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
decreases activity
multiple interactions
EXP
ISO
CYP2D6 protein results in increased metabolism of Lithocholic Acid
Lithocholic Acid results in decreased activity of CYP2D22 protein
[CYP2D6 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of hyodeoxycholic acid
CTD PMID:18039809, PMID:18420780 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Lithocholic Acid results in decreased activity of CYP2E1 protein CTD PMID:18420780 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp39a1 cytochrome P450, family 39, subfamily a, polypeptide 1 multiple interactions ISO [1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Lithocholic Acid] results in increased expression of CYP39A1 mRNA; [Phenobarbital co-treated with Lithocholic Acid] results in increased expression of CYP39A1 mRNA; NR1I3 protein promotes the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Lithocholic Acid] results in increased expression of CYP39A1 mRNA]; NR1I3 protein promotes the reaction [[Phenobarbital co-treated with Lithocholic Acid] results in increased expression of CYP39A1 mRNA] CTD PMID:19196849 NCBI chr 9:19,804,079...19,880,346
Ensembl chr 9:19,804,079...19,880,346
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
decreases activity
increases metabolic processing
multiple interactions
EXP Lithocholic Acid results in increased expression of CYP3A2 mRNA
Lithocholic Acid results in decreased activity of CYP3A2 protein
CYP3A2 protein results in increased metabolism of Lithocholic Acid
[CYP3A2 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of 3-oxocholan-24-oic acid; [CYP3A2 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of Lithocholic Acid analog
CTD PMID:8889968, PMID:18039809, PMID:20006981, PMID:20888898 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions
increases expression
increases metabolic processing
EXP [CYP3A23-3A1 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of 3-oxocholan-24-oic acid; [CYP3A23-3A1 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of Lithocholic Acid analog; [Lithocholic Acid binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A23-3A1 mRNA; Chenodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of CYP3A23-3A1 mRNA] CTD PMID:18039809, PMID:20006981, PMID:20888898, PMID:21311750 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases expression
increases oxidation
multiple interactions
EXP
ISO
Lithocholic Acid results in increased expression of CYP3A9 mRNA
CYP3A5 protein results in increased oxidation of Lithocholic Acid
[CYP3A5 protein results in increased oxidation of Lithocholic Acid] which results in increased chemical synthesis of 3-ketocholanoic acid; CYP3A5 gene polymorphism affects the reaction [CYP3A5 gene results in increased oxidation of Lithocholic Acid]; Ketoconazole inhibits the reaction [CYP3A5 protein results in increased oxidation of Lithocholic Acid]; plastochromanol 8 inhibits the reaction [CYP3A5 protein results in increased oxidation of Lithocholic Acid]; tocotrienol, alpha inhibits the reaction [CYP3A5 protein results in increased oxidation of Lithocholic Acid]; tocotrienol, delta inhibits the reaction [CYP3A5 protein results in increased oxidation of Lithocholic Acid]; Tocotrienols inhibits the reaction [CYP3A5 protein results in increased oxidation of Lithocholic Acid]
CTD PMID:20888898, PMID:31102695 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 decreases expression
multiple interactions
ISO Lithocholic Acid results in decreased expression of CYP4F14 mRNA
Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of CYP4F14 mRNA]
CTD PMID:20359477 NCBI chr 7:15,179,472...15,191,113
Ensembl chr 7:15,179,467...15,190,796
JBrowse link
G Cyp51 cytochrome P450, family 51 decreases expression ISO Lithocholic Acid results in decreased expression of CYP51 mRNA CTD PMID:20359477 NCBI chr 4:27,175,564...27,194,018
Ensembl chr 4:27,175,243...27,194,018
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression
multiple interactions
decreases activity
EXP
ISO
Lithocholic Acid results in decreased expression of CYP7A1 mRNA
[Lithocholic Acid analog binds to and results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA; [Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA
1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7A1 mRNA]; [Lithocholic Acid results in increased activity of NR1H4 protein] which results in increased expression of CYP7A1 mRNA; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7A1 mRNA]]; Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7A1 mRNA]
Lithocholic Acid results in decreased activity of CYP7A1 protein
CTD PMID:1175606, PMID:16436656, PMID:17963371, PMID:19196849, PMID:20359477, PMID:20671298, PMID:20888898, PMID:22531947, PMID:22982774, PMID:23034213, PMID:25055961, PMID:25582706 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 decreases expression
multiple interactions
ISO Lithocholic Acid results in decreased expression of CYP7B1 mRNA
1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7B1 mRNA]; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7B1 mRNA]]; NR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7B1 mRNA]]; Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7B1 mRNA]
CTD PMID:19196849 NCBI chr 2:102,701,903...102,871,257
Ensembl chr 2:102,701,903...102,871,257
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 multiple interactions
decreases expression
ISO 1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA]; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA]]; NR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA]]; Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA]; Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA] CTD PMID:16436656, PMID:19196849, PMID:20359477, PMID:25582706 NCBI chr 8:130,548,418...130,550,388
Ensembl chr 8:130,548,418...130,550,388
JBrowse link
G Degs1 delta(4)-desaturase, sphingolipid 1 increases expression ISO Lithocholic Acid results in increased expression of DEGS1 mRNA CTD PMID:21480330 NCBI chr13:100,665,265...100,672,731
Ensembl chr13:100,666,075...100,672,731
JBrowse link
G Dhrs11 dehydrogenase/reductase 11 increases oxidation ISO DHRS11 protein results in increased oxidation of Lithocholic Acid CTD PMID:30926317 NCBI chr10:72,144,042...72,153,496
Ensembl chr10:72,144,042...72,153,375
JBrowse link
G Dio2 iodothyronine deiodinase 2 increases expression
multiple interactions
increases activity
ISO Lithocholic Acid results in increased expression of DIO2 mRNA
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Lithocholic Acid results in increased activity of DIO2 protein]
CTD PMID:19036883 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
JBrowse link
G Dio3 iodothyronine deiodinase 3 increases activity ISO Lithocholic Acid results in increased activity of DIO3 protein CTD PMID:19036883 NCBI chr 6:134,627,278...134,629,139
Ensembl chr 6:134,627,278...134,629,138
JBrowse link
G Dmp1 dentin matrix acidic phosphoprotein 1 increases expression ISO Lithocholic Acid results in increased expression of DMP1 mRNA CTD PMID:19000923 NCBI chr14:6,889,851...6,923,961
Ensembl chr14:6,889,856...6,900,733
JBrowse link
G Efna1 ephrin A1 multiple interactions ISO Lithocholic Acid analog inhibits the reaction [EPHA2 protein binds to EFNA1 protein]; Lithocholic Acid inhibits the reaction [[EPHA2 protein binds to EFNA1 protein] which results in increased phosphorylation of EPHA2 protein]; Lithocholic Acid inhibits the reaction [EFNA1 protein binds to EPHA2 protein]; Lithocholic Acid inhibits the reaction [EPHA2 protein binds to EFNA1 protein] CTD PMID:21479221, PMID:22529030, PMID:23489211 NCBI chr 2:188,588,808...188,596,156
Ensembl chr 2:188,588,796...188,596,222
JBrowse link
G Efnb2 ephrin B2 multiple interactions ISO Lithocholic Acid inhibits the reaction [[EPHB4 protein binds to EFNB2 protein] which results in increased phosphorylation of EPHB4 protein] CTD PMID:21479221 NCBI chr16:86,631,151...86,672,050
Ensembl chr16:86,631,064...86,675,049
JBrowse link
G Egf epidermal growth factor multiple interactions ISO EGF protein promotes the reaction [Lithocholic Acid results in increased activity of ALPL protein]; EGF protein promotes the reaction [Lithocholic Acid results in increased activity of TGFB1 protein] CTD PMID:19646460 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Epha2 Eph receptor A2 multiple interactions
increases expression
ISO Lithocholic Acid analog binds to and results in decreased phosphorylation of and results in decreased activity of EPHA2 protein; Lithocholic Acid analog inhibits the reaction [EPHA2 protein binds to EFNA1 protein]; Lithocholic Acid binds to and results in decreased activity of EPHA2 protein; Lithocholic Acid inhibits the reaction [[EPHA2 protein binds to EFNA1 protein] which results in increased phosphorylation of EPHA2 protein]; Lithocholic Acid inhibits the reaction [EFNA1 protein binds to EPHA2 protein]; Lithocholic Acid inhibits the reaction [EPHA2 protein binds to EFNA1 protein]
Lithocholic Acid results in increased expression of EPHA2 protein
Lithocholic Acid inhibits the reaction [Doxazosin results in increased phosphorylation of and results in increased activity of EPHA2 protein]
CTD PMID:21479221, PMID:22529030, PMID:22845314, PMID:23489211 NCBI chr 5:159,845,773...159,874,203
Ensembl chr 5:159,845,774...159,874,206
JBrowse link
G Ephb4 EPH receptor B4 multiple interactions ISO Lithocholic Acid inhibits the reaction [[EPHB4 protein binds to EFNB2 protein] which results in increased phosphorylation of EPHB4 protein] CTD PMID:21479221 NCBI chr12:22,393,338...22,418,332
Ensembl chr12:22,393,330...22,417,980
JBrowse link
G Ephx1 epoxide hydrolase 1 multiple interactions ISO [Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in increased expression of EPHX1 mRNA CTD PMID:20359477 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Fabp6 fatty acid binding protein 6 increases expression ISO Lithocholic Acid results in increased expression of FABP6 mRNA CTD PMID:15821044, PMID:25582706 NCBI chr10:29,191,621...29,196,593
Ensembl chr10:29,191,623...29,196,563
JBrowse link
G Fads1 fatty acid desaturase 1 decreases expression ISO Lithocholic Acid results in decreased expression of FADS1 mRNA CTD PMID:20359477 NCBI chr 1:226,234,034...226,249,118
Ensembl chr 1:226,234,074...226,249,138
JBrowse link
G Fads2 fatty acid desaturase 2 decreases expression ISO Lithocholic Acid results in decreased expression of FADS2 mRNA CTD PMID:20359477 NCBI chr 1:225,906,582...226,152,568
Ensembl chr 1:226,114,413...226,152,524
JBrowse link
G Fads6 fatty acid desaturase 6 decreases expression ISO Lithocholic Acid results in decreased expression of FADS6 mRNA CTD PMID:20359477 NCBI chr10:103,832,838...103,848,035
Ensembl chr10:103,832,838...103,848,035
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO [[[[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein] which results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein; [[[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein] which results in increased activity of CASP9 protein; [[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein; [[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein; [Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased activity of FAS protein; [Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein; Lithocholic Acid results in increased localization of and results in increased activity of FAS protein CTD PMID:19054763 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fasn fatty acid synthase multiple interactions
decreases expression
ISO Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of FASN mRNA] CTD PMID:20359477 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fgb fibrinogen beta chain multiple interactions EXP [Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of FGB mRNA CTD PMID:21311750 NCBI chr 2:182,028,044...182,035,026
Ensembl chr 2:182,027,115...182,038,178
JBrowse link
G Fgf19 fibroblast growth factor 19 multiple interactions
increases expression
ISO [Lithocholic Acid results in increased activity of NR1H4 protein] which results in increased expression of FGF19 mRNA; [Lithocholic Acid results in increased activity of NR1I2 protein] which results in increased expression of FGF19 mRNA; NR1I2 protein promotes the reaction [Lithocholic Acid results in increased expression of FGF19 mRNA]
Lithocholic Acid results in increased expression of FGF15 mRNA
CTD PMID:17696253, PMID:22561792, PMID:25055961, PMID:25582706 NCBI chr 1:218,058,405...218,061,693
Ensembl chr 1:218,058,405...218,061,693
JBrowse link
G Ftl1 ferritin light chain 1 multiple interactions ISO [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of FTL mRNA CTD PMID:17724089 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
JBrowse link
G Gcg glucagon multiple interactions
increases secretion
ISO GNAT3 protein promotes the reaction [Lithocholic Acid results in increased secretion of GCG protein] CTD PMID:23341498 NCBI chr 3:48,442,635...48,451,650
Ensembl chr 3:48,442,635...48,451,650
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
decreases expression
multiple interactions
affects expression
ISO Lithocholic Acid results in increased expression of GCLC mRNA; Lithocholic Acid results in increased expression of GCLC protein
Lithocholic Acid results in decreased expression of GCLC mRNA
[Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA; [Lithocholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione; Buthionine Sulfoximine inhibits the reaction [[Lithocholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione]; S-Adenosylmethionine inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]]; Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]
Lithocholic Acid affects the expression of GCLC mRNA; Lithocholic Acid affects the expression of GCLC protein
[Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of GCLC mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of GCLC protein]; Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in decreased expression of GCLC mRNA]
CTD PMID:17724089, PMID:20146260, PMID:20977460, PMID:29794447 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit affects expression
decreases expression
multiple interactions
increases expression
ISO Lithocholic Acid affects the expression of GCLM mRNA; Lithocholic Acid affects the expression of GCLM protein
Lithocholic Acid results in decreased expression of GCLM mRNA
[Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLM mRNA; Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in decreased expression of GCLM mRNA]
Lithocholic Acid results in increased expression of GCLM protein
[Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLM mRNA; [Lithocholic Acid results in increased expression of GCLM protein] which results in increased abundance of Glutathione; Buthionine Sulfoximine inhibits the reaction [[Lithocholic Acid results in increased expression of GCLM protein] which results in increased abundance of Glutathione]
CTD PMID:17724089, PMID:20146260, PMID:29794447 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gnat3 G protein subunit alpha transducin 3 multiple interactions ISO GNAT3 protein promotes the reaction [Lithocholic Acid results in increased secretion of GCG protein] CTD PMID:23341498 NCBI chr 4:13,827,764...13,878,126
Ensembl chr 4:13,827,756...13,878,126
JBrowse link
G Gpbar1 G protein-coupled bile acid receptor 1 affects binding
increases expression
multiple interactions
increases response to substance
ISO Lithocholic Acid binds to GPBAR1 protein
Lithocholic Acid results in increased expression of GPBAR1 mRNA
[Lithocholic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased abundance of Cyclic AMP; Lithocholic Acid analog binds to and results in increased activity of GPBAR1 protein; Lithocholic Acid binds to and results in increased activity of GPBAR1 protein
GPBAR1 protein results in increased susceptibility to Lithocholic Acid
CTD PMID:17963371, PMID:18180267, PMID:20023205, PMID:21454404, PMID:23041323, PMID:23566200, PMID:25055961 NCBI chr 9:81,555,914...81,560,931
Ensembl chr 9:81,559,605...81,560,594
JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression ISO Lithocholic Acid results in increased expression of GPT protein CTD PMID:24742700 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO Lithocholic Acid results in increased phosphorylation of and results in decreased activity of GSK3B protein CTD PMID:20512997 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gss glutathione synthetase affects expression
multiple interactions
ISO Lithocholic Acid affects the expression of GSS mRNA; Lithocholic Acid affects the expression of GSS protein
S-Adenosylmethionine inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]]; Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]
CTD PMID:20146260 NCBI chr 3:151,076,254...151,106,557
Ensembl chr 3:151,076,254...151,106,557
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions ISO
EXP
Lithocholic Acid binds to and results in decreased activity of GSTA1 protein
Lithocholic Acid binds to [GSTA1 protein co-treated with GSTA1 protein]; Lithocholic Acid binds to [GSTA3 protein co-treated with GSTA1 protein]
CTD PMID:3783048, PMID:12206662 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression EXP Lithocholic Acid results in increased expression of GSTA2 mRNA CTD PMID:21311750 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta3 glutathione S-transferase alpha 3 multiple interactions EXP Lithocholic Acid binds to [GSTA3 protein co-treated with GSTA1 protein] CTD PMID:3783048 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
JBrowse link
G Gsta4 glutathione S-transferase alpha 4 multiple interactions
increases expression
EXP Lithocholic Acid binds to and results in decreased activity of GSTA4 protein
Lithocholic Acid results in increased expression of GSTA4 mRNA
CTD PMID:3954743, PMID:21311750 NCBI chr 8:85,497,557...85,514,732
Ensembl chr 8:85,497,557...85,518,879
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression
multiple interactions
ISO
EXP
Lithocholic Acid results in increased expression of GSTM1 mRNA
NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of GSTM1 mRNA]
Lithocholic Acid binds to and results in decreased activity of GSTM1 protein
CTD PMID:3954743, PMID:20977460 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstm2 glutathione S-transferase mu 2 multiple interactions
increases expression
EXP Lithocholic Acid binds to and results in decreased activity of GSTM2 protein
Lithocholic Acid results in increased expression of GSTM2 mRNA
CTD PMID:3954743, PMID:21311750 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO [Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in increased expression of HMGCR mRNA CTD PMID:20359477 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 multiple interactions
decreases expression
ISO Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of HMGCS2 mRNA] CTD PMID:20359477 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases expression
increases expression
ISO NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of HMOX1 protein]; Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in decreased expression of HMOX1 mRNA]
Lithocholic Acid results in increased expression of HMOX1 mRNA; Lithocholic Acid results in increased expression of HMOX1 protein
[Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 mRNA; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of HMOX1 protein]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of HMOX1 protein]]
CTD PMID:17724089, PMID:20977460, PMID:24742700, PMID:29794447, PMID:31472180 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnf1a HNF1 homeobox A decreases expression EXP Lithocholic Acid results in decreased expression of HNF1A mRNA CTD PMID:20888898 NCBI chr12:47,407,811...47,433,342
Ensembl chr12:47,407,811...47,433,342
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha decreases expression
multiple interactions
EXP
ISO
Lithocholic Acid results in decreased expression of HNF4A mRNA
[Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of HNF4A mRNA
CTD PMID:20359477, PMID:20888898 NCBI chr 3:159,902,441...159,965,003
Ensembl chr 3:159,902,441...159,965,003
JBrowse link
G Hr HR, lysine demethylase and nuclear receptor corepressor multiple interactions ISO HR protein inhibits the reaction [Lithocholic Acid results in increased activity of VDR protein]; HR protein inhibits the reaction [Lithocholic Acid results in increased expression of CYP24A1 mRNA]; HR protein promotes the reaction [Lithocholic Acid results in increased expression of CAMP mRNA]; Lithocholic Acid promotes the reaction [VDR protein binds to HR protein]; trichostatin A inhibits the reaction [HR protein inhibits the reaction [Lithocholic Acid results in increased activity of VDR protein]] CTD PMID:22466564 NCBI chr15:52,241,801...52,261,276
Ensembl chr15:52,241,801...52,261,276
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases phosphorylation ISO Lithocholic Acid results in increased phosphorylation of HSPB1 protein CTD PMID:21224350 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO Lithocholic Acid results in increased expression of ICAM1 mRNA; Lithocholic Acid results in increased expression of ICAM1 protein CTD PMID:16582018, PMID:24742700 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 decreases expression ISO Lithocholic Acid results in decreased expression of IDH1 mRNA CTD PMID:20359477 NCBI chr 9:71,882,108...71,911,645
Ensembl chr 9:71,882,105...71,900,044
JBrowse link
G Il10 interleukin 10 increases expression
decreases abundance
ISO Lithocholic Acid results in increased expression of IL10 mRNA
IL10 gene mutant form results in decreased abundance of Lithocholic Acid
CTD PMID:24742700, PMID:27580383 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO Lithocholic Acid inhibits the reaction [IL1B protein results in increased degradation of NFKBIA protein]; Lithocholic Acid inhibits the reaction [IL1B protein results in increased expression of CXCL8 protein]; Lithocholic Acid inhibits the reaction [IL1B protein results in increased phosphorylation of RELA protein]
Lithocholic Acid results in increased expression of and results in increased secretion of IL1B protein; Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in increased expression of and results in increased secretion of IL1B protein]; Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in increased expression of IL1B mRNA]
CTD PMID:18515093, PMID:24742700, PMID:29794447 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO Lithocholic Acid results in increased expression of IL6 mRNA; Lithocholic Acid results in increased expression of IL6 protein
Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in increased expression of IL6 protein]
CTD PMID:24742700, PMID:29794447 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 multiple interactions ISO [Lithocholic Acid co-treated with Glucose] results in increased secretion of INS protein CTD PMID:23022524 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Itgam integrin subunit alpha M increases expression ISO Lithocholic Acid analog results in increased expression of ITGAM mRNA CTD PMID:18180267 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Itgb1 integrin subunit beta 1 decreases metabolic processing ISO Lithocholic Acid results in decreased metabolism of ITGB1 protein CTD PMID:21224350 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO Lithocholic Acid results in increased expression of JUN mRNA CTD PMID:19000923 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression ISO Lithocholic Acid results in increased expression of JUNB mRNA CTD PMID:19000923 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 multiple interactions
increases response to substance
ISO
EXP
[KCNMB1 protein co-treated with KCNMA1 protein] results in increased susceptibility to Lithocholic Acid; Lithocholic Acid promotes the reaction [[KCNMB1 protein co-treated with KCNMA1 protein] results in increased transport of Calcium]; Lithocholic Acid results in increased activity of [KCNMB1 protein co-treated with KCNMA1 protein]
KCNMA1 mRNA alternative form results in increased susceptibility to Lithocholic Acid
KCNMA1 mRNA alternative form results in increased susceptibility to Lithocholic Acid; KCNMA1 protein results in increased susceptibility to Lithocholic Acid
Lithocholic Acid analog results in increased activity of [KCNMB1 protein co-treated with KCNMA1 protein]; Lithocholic Acid results in increased activity of [KCNMB1 protein co-treated with KCNMA1 protein]
CTD PMID:18242174, PMID:18650555, PMID:22123969, PMID:28090300 NCBI chr15:344,204...1,048,849
Ensembl chr15:344,360...1,047,956
JBrowse link
G Kcnmb1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 multiple interactions
increases response to substance
affects binding
increases activity
ISO
EXP
[KCNMB1 protein co-treated with KCNMA1 protein] results in increased susceptibility to Lithocholic Acid; Lithocholic Acid promotes the reaction [[KCNMB1 protein co-treated with KCNMA1 protein] results in increased transport of Calcium]; Lithocholic Acid results in increased activity of [KCNMB1 protein co-treated with KCNMA1 protein]
KCNMB1 protein results in increased susceptibility to Lithocholic Acid
Lithocholic Acid analog results in increased activity of [KCNMB1 protein co-treated with KCNMA1 protein]; Lithocholic Acid results in increased activity of [KCNMB1 protein co-treated with KCNMA1 protein]
Lithocholic Acid binds to KCNMB1 protein
Lithocholic Acid analog results in increased activity of KCNMB1 protein; Lithocholic Acid results in increased activity of KCNMB1 protein
CTD PMID:17468198, PMID:18650555, PMID:19852931, PMID:22123969, PMID:22945504 NCBI chr10:18,910,586...18,922,856
Ensembl chr10:18,906,010...18,919,639
JBrowse link
G Klk6 kallikrein related-peptidase 6 multiple interactions EXP [Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of KLK6 mRNA CTD PMID:21311750 NCBI chr 1:99,762,195...99,769,486
Ensembl chr 1:99,762,253...99,769,488
JBrowse link
G Lcat lecithin cholesterol acyltransferase decreases expression
multiple interactions
ISO Lithocholic Acid results in decreased expression of LCAT mRNA
[Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of LCAT mRNA
CTD PMID:20359477 NCBI chr19:37,913,333...37,916,799
Ensembl chr19:37,913,336...37,916,813
JBrowse link
G Ldlr low density lipoprotein receptor decreases expression ISO Lithocholic Acid results in decreased expression of LDLR mRNA CTD PMID:20359477 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Lpcat1 lysophosphatidylcholine acyltransferase 1 increases expression
multiple interactions
ISO Lithocholic Acid results in increased expression of LPCAT1 mRNA
NR1H4 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT1 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT1 mRNA]
CTD PMID:21480330, PMID:23034213 NCBI chr 1:32,379,431...32,429,917
Ensembl chr 1:32,379,432...32,429,917
JBrowse link
G Lpcat2 lysophosphatidylcholine acyltransferase 2 increases expression
multiple interactions
ISO Lithocholic Acid results in increased expression of LPCAT2 mRNA
NR1H4 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT2 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT2 mRNA]
CTD PMID:21480330, PMID:23034213 NCBI chr19:15,470,177...15,540,704
Ensembl chr19:15,469,303...15,540,773
JBrowse link
G Lpcat3 lysophosphatidylcholine acyltransferase 3 decreases expression ISO Lithocholic Acid results in decreased expression of LPCAT3 mRNA CTD PMID:21480330 NCBI chr 4:157,181,722...157,222,997
Ensembl chr 4:157,181,795...157,222,996
JBrowse link
G Lpcat4 lysophosphatidylcholine acyltransferase 4 increases expression
multiple interactions
ISO Lithocholic Acid results in increased expression of LPCAT4 mRNA
NR1H4 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT4 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT4 mRNA]
CTD PMID:21480330, PMID:23034213 NCBI chr 3:103,725,762...103,733,888
Ensembl chr 3:103,726,238...103,733,354
JBrowse link
G Lpl lipoprotein lipase increases expression ISO Lithocholic Acid results in increased expression of LPL mRNA CTD PMID:20359477 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Lrp2 LDL receptor related protein 2 decreases expression ISO Lithocholic Acid results in decreased expression of LRP2 protein CTD PMID:15375181 NCBI chr 3:55,665,153...55,822,484
Ensembl chr 3:55,665,145...55,822,551
JBrowse link
G Lypla1 lysophospholipase 1 multiple interactions
decreases expression
ISO [Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of LYPLA1 mRNA
Lithocholic Acid results in decreased expression of LYPLA1 mRNA
CTD PMID:20359477, PMID:21480330 NCBI chr 5:14,559,333...14,588,447
Ensembl chr 5:14,559,334...14,588,422
JBrowse link
G Maf MAF bZIP transcription factor multiple interactions ISO Lithocholic Acid results in increased expression of and results in increased activity of MAF protein; S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein]]; Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein] CTD PMID:20146260 NCBI chr19:48,179,826...48,200,995
Ensembl chr19:48,194,804...48,196,748
JBrowse link
G Mafg MAF bZIP transcription factor G multiple interactions ISO Lithocholic Acid results in increased expression of and results in increased activity of MAFG protein; S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein]]; Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein] CTD PMID:20146260 NCBI chr10:109,802,877...109,811,476
Ensembl chr10:109,806,159...109,811,323
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO MAP2K1 protein promotes the reaction [Lithocholic Acid results in increased expression of PLAUR mRNA] CTD PMID:19782465 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases activity
ISO [Lithocholic Acid results in increased activity of MAPK1 protein] which results in increased expression of PLAUR mRNA; MAPK1 protein promotes the reaction [Lithocholic Acid results in increased expression of PLAUR mRNA] CTD PMID:19782465 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases activity
ISO [Lithocholic Acid results in increased activity of MAPK3 protein] which results in increased expression of PLAUR mRNA CTD PMID:19782465 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member affects localization
multiple interactions
increases expression
ISO Lithocholic Acid affects the localization of MCL1 protein
1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid affects the localization of MCL1 protein]; [Lithocholic Acid co-treated with oltipraz] results in increased expression of MCL1 mRNA; Phenobarbital inhibits the reaction [Lithocholic Acid affects the localization of MCL1 protein]; Phenobarbital inhibits the reaction [Lithocholic Acid results in increased expression of MCL1 mRNA]; Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid affects the localization of MCL1 protein]
CTD PMID:19433268 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
increases expression
ISO Lithocholic Acid results in decreased expression of MMP2 protein
Lithocholic Acid results in increased expression of MMP2 mRNA
CTD PMID:16436656, PMID:21224350 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO Lithocholic Acid results in decreased expression of MMP9 protein CTD PMID:21224350 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mras muscle RAS oncogene homolog affects binding EXP Lithocholic Acid binds to MRAS protein CTD PMID:18641422 NCBI chr 8:107,629,028...107,656,851
Ensembl chr 8:107,629,028...107,681,512
JBrowse link
G Mt1 metallothionein 1 increases expression EXP
ISO
Lithocholic Acid results in increased expression of MT1A mRNA
Lithocholic Acid results in increased expression of MT1 mRNA
CTD PMID:21311750, PMID:24742700 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt2A metallothionein 2A increases expression EXP Lithocholic Acid results in increased expression of MT2A mRNA CTD PMID:21311750 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Lithocholic Acid inhibits the reaction [NR1I3 protein binds to NCOA1 protein]
Lithocholic Acid promotes the reaction [VDR protein binds to NCOA1 protein]
CTD PMID:15489543, PMID:21917910, PMID:22466564, PMID:23015691 NCBI chr 6:28,677,563...28,931,844
Ensembl chr 6:28,677,540...28,931,843
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions ISO Lithocholic Acid inhibits the reaction [VDR protein binds to NCOR1 protein] CTD PMID:22466564 NCBI chr10:48,629,121...48,772,890
Ensembl chr10:48,629,121...48,772,890
JBrowse link
G Ncor2 nuclear receptor co-repressor 2 multiple interactions ISO Lithocholic Acid inhibits the reaction [NCOR2 protein binds to CYP24A1 promoter]; Lithocholic Acid inhibits the reaction [VDR protein binds to NCOR2 protein]; Lithocholic Acid promotes the reaction [VDR protein binds to NCOR2 protein] CTD PMID:21917910, PMID:22466564 NCBI chr12:36,871,917...37,033,701
Ensembl chr12:36,871,999...37,033,701
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
decreases expression
decreases response to substance
ISO [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA; [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLM mRNA; [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA; [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of TXN1 mRNA; Lithocholic Acid results in increased localization of and results in increased activity of NFE2L2 protein; NFE2L2 protein inhibits the reaction [Lithocholic Acid results in increased expression of GSTA4 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCA1 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC1 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC2 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC2 protein]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC3 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC4 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC5 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCG2 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of GCLC mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of GCLC protein]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of GSTM1 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of HMOX1 protein]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of NQO1 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of TXNRD1 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of TXNRD1 protein]; Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 mRNA]; Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein]
Lithocholic Acid results in decreased expression of NFE2L2 mRNA; Lithocholic Acid results in decreased expression of NFE2L2 protein
NFE2L2 protein results in decreased susceptibility to Lithocholic Acid
[Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of FTL mRNA; [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA; [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLM mRNA; [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 mRNA; [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA; [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of TXN mRNA; [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of TXNRD1 mRNA; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of and affects the localization of NFE2L2 protein]; Lithocholic Acid results in decreased expression of and results in decreased activity of NFE2L2 protein; Lithocholic Acid results in increased expression of and results in increased localization of and results in increased activity of NFE2L2 protein; S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein]]; Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of NFE2L2 protein]]
CTD PMID:17724089, PMID:20146260, PMID:20977460, PMID:29794447, PMID:31472180 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Lithocholic Acid inhibits the reaction [IL1B protein results in increased degradation of NFKBIA protein]; Lithocholic Acid inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Lithocholic Acid inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]]; VDR protein promotes the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]] CTD PMID:18515093, PMID:31472180 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions
increases expression
ISO Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in increased expression of NLRP3 mRNA]; Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in increased expression of NLRP3 protein]
Lithocholic Acid results in increased expression of NLRP3 mRNA; Lithocholic Acid results in increased expression of NLRP3 protein
CTD PMID:29794447 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
decreases expression
multiple interactions
ISO Lithocholic Acid results in increased expression of NQO1 mRNA
Lithocholic Acid results in decreased expression of NQO1 mRNA
[Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA
[Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of NQO1 mRNA]; Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in decreased expression of NQO1 mRNA]
CTD PMID:17724089, PMID:20977460, PMID:29794447 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression
multiple interactions
decreases expression
EXP
ISO
Lithocholic Acid results in increased expression of NR0B2 mRNA
Lithocholic Acid results in increased expression of NR0B2 mRNA; Lithocholic Acid results in increased expression of NR0B2 protein
[Lithocholic Acid analog binds to and results in increased activity of NR1H4 protein] which results in increased expression of NR0B2 mRNA; [Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of NR0B2 mRNA
[Lithocholic Acid binds to VDR protein] which results in increased expression of NR0B2 mRNA
Lithocholic Acid results in decreased expression of NR0B2 mRNA
[Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of NR0B2 mRNA
CTD PMID:17963371, PMID:19562681, PMID:20359477, PMID:20888898, PMID:22540009, PMID:22982774, PMID:25055961, PMID:25582706, PMID:30419252 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 decreases expression
decreases response to substance
multiple interactions
EXP
ISO
Lithocholic Acid results in decreased expression of NR1H3 mRNA
NR1H3 protein results in decreased susceptibility to Lithocholic Acid
Lithocholic Acid inhibits the reaction [NR1H3 protein results in increased expression of SLC51A mRNA]; Lithocholic Acid inhibits the reaction [NR1H3 protein results in increased expression of SLCO1B2 mRNA]; Lithocholic Acid promotes the reaction [NR1H3 protein results in increased expression of ABCB11 mRNA]; Lithocholic Acid promotes the reaction [NR1H3 protein results in increased expression of ABCC4 mRNA]; NR1H3 protein inhibits the reaction [Lithocholic Acid results in decreased expression of SLC10A1 mRNA]; NR1H3 protein inhibits the reaction [Lithocholic Acid results in increased expression of SLC10A2 mRNA]; NR1H3 protein inhibits the reaction [Lithocholic Acid results in increased expression of SLC51B mRNA]
CTD PMID:17256725, PMID:20359477, PMID:20888898 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
increases expression
increases activity
increases response to substance
decreases expression
EXP
ISO
[Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of FGB mRNA; [Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of UGT2B15 mRNA; Lithocholic Acid binds to and results in increased activity of NR1H4 protein; NR1H4 protein inhibits the reaction [Lithocholic Acid results in increased expression of CYP3A11 mRNA]
[Lithocholic Acid analog binds to and results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA; [Lithocholic Acid analog binds to and results in increased activity of NR1H4 protein] which results in increased expression of ABCB11 mRNA; [Lithocholic Acid analog binds to and results in increased activity of NR1H4 protein] which results in increased expression of NR0B2 mRNA; [Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA; [Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of ABCB11 mRNA; [Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of NR0B2 mRNA; [Lithocholic Acid promotes the reaction [NR1H4 protein binds to UGT2B7 promoter]] which results in decreased expression of UGT2B7 mRNA; [Lithocholic Acid results in increased activity of NR1H4 protein] which results in increased expression of FGF19 mRNA; Lithocholic Acid analog binds to and results in increased activity of NR1H4 protein; Lithocholic Acid binds to and results in decreased activity of NR1H4 protein; Lithocholic Acid binds to and results in increased activity of NR1H4 protein; Lithocholic Acid inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; Lithocholic Acid inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Lithocholic Acid promotes the reaction [NR1H4 protein binds to UGT2B7 promoter]
Lithocholic Acid results in increased expression of NR1H4 mRNA
NR1H4 protein results in increased susceptibility to Lithocholic Acid; NR1H4 results in increased susceptibility to Lithocholic Acid
1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid inhibits the reaction [NR1I3 protein results in increased expression of NR1H4 mRNA]]; [Lithocholic Acid results in increased activity of NR1H4 protein] which results in increased expression of CYP7A1 mRNA; Lithocholic Acid inhibits the reaction [NR1I3 protein results in increased expression of NR1H4 mRNA]; NR1H4 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT1 mRNA]; NR1H4 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT2 mRNA]; NR1H4 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT4 mRNA]; NR1H4 protein promotes the reaction [Lithocholic Acid results in increased expression of TGFB1 mRNA]; Phenobarbital inhibits the reaction [Lithocholic Acid inhibits the reaction [NR1I3 protein results in increased expression of NR1H4 mRNA]]
Lithocholic Acid results in decreased expression of NR1H4 mRNA
CTD PMID:12875239, PMID:14684751, PMID:15489543, PMID:15821044, PMID:17963371, PMID:18180267, PMID:19196849, PMID:19965603, PMID:20359477, PMID:20888898, PMID:21291553, PMID:21311750, PMID:21480330, PMID:21543282, PMID:22531947, PMID:22561792, PMID:25055961, PMID:25257666, PMID:27871908 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 decreases response to substance
increases response to substance
decreases expression
multiple interactions
increases localization
increases activity
ISO
EXP
NR1I2 protein results in decreased susceptibility to Lithocholic Acid
NR1I2 results in increased susceptibility to Lithocholic Acid
Lithocholic Acid results in decreased expression of NR1I2 mRNA; Lithocholic Acid results in decreased expression of NR1I2 protein
[Lithocholic Acid binds to and results in increased activity of NR1I2 protein] which results in increased expression of ABCC2 mRNA; [Lithocholic Acid binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A23-3A1 mRNA; [NR1I2 protein co-treated with RXRA protein] promotes the reaction [Lithocholic Acid results in increased expression of SULT2A1 mRNA]; Lithocholic Acid binds to and results in increased activity of NR1I2 protein
Lithocholic Acid results in increased localization of NR1I2 protein
[Lithocholic Acid results in increased activity of NR1I2 protein] which results in increased expression of ABCC2 mRNA; [Lithocholic Acid results in increased activity of NR1I2 protein] which results in increased expression of ABCC3 mRNA; [Lithocholic Acid results in increased activity of NR1I2 protein] which results in increased expression of CYP3A11 mRNA; [Lithocholic Acid results in increased activity of NR1I2 protein] which results in increased expression of FGF19 mRNA; Lithocholic Acid analog binds to and results in increased activity of NR1I2 protein; Lithocholic Acid binds to and results in increased activity of NR1I2 protein; NR1I2 protein promotes the reaction [Lithocholic Acid results in increased expression of FGF19 mRNA]
CTD PMID:12370413, PMID:14570758, PMID:15358766, PMID:15883047, PMID:16054614, PMID:17696253, PMID:17963371, PMID:19797606, PMID:20888898, PMID:21311750, PMID:21977915, PMID:22561792, PMID:27871908 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression
decreases response to substance
decreases expression
multiple interactions
ISO Lithocholic Acid results in increased expression of NR1I3 mRNA
NR1I3 protein results in decreased susceptibility to Lithocholic Acid
Lithocholic Acid results in decreased expression of NR1I3 mRNA
1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid inhibits the reaction [NR1I3 protein results in increased expression of NR1H4 mRNA]]; 1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [Lithocholic Acid affects the localization of and results in increased activity of NR1I3 protein]; [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased activity of NR1I3 protein] which results in decreased susceptibility to Lithocholic Acid; [Phenobarbital results in increased activity of NR1I3 protein] which results in decreased susceptibility to Lithocholic Acid; Lithocholic Acid affects the localization of and results in increased activity of NR1I3 protein; Lithocholic Acid inhibits the reaction [NR1I3 protein binds to NCOA1 protein]; Lithocholic Acid inhibits the reaction [NR1I3 protein results in increased expression of NR1H4 mRNA]; NR1I3 protein affects the reaction [Lithocholic Acid results in increased expression of ABCC3 mRNA]; NR1I3 protein affects the reaction [Lithocholic Acid results in increased expression of CYP2B10 mRNA]; NR1I3 protein affects the reaction [Lithocholic Acid results in increased expression of CYP3A11 mRNA]; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of BAAT mRNA]]; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP27A1 mRNA]]; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7A1 mRNA]]; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7B1 mRNA]]; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA]]; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of UGT1A1 mRNA]]; NR1I3 protein promotes the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Lithocholic Acid] results in increased expression of CYP2B10 mRNA]; NR1I3 protein promotes the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Lithocholic Acid] results in increased expression of CYP39A1 mRNA]; NR1I3 protein promotes the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Lithocholic Acid] results in increased expression of CYP3A11 mRNA]; NR1I3 protein promotes the reaction [[Phenobarbital co-treated with Lithocholic Acid] results in increased expression of CYP39A1 mRNA]; NR1I3 protein promotes the reaction [[Phenobarbital co-treated with Lithocholic Acid] results in increased expression of CYP3A11 mRNA]; NR1I3 protein promotes the reaction [[Pregnenolone Carbonitrile co-treated with Lithocholic Acid] results in increased expression of CYP2B10 mRNA]; NR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of BAAT mRNA]]; NR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of CYP27A1 mRNA]]; NR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7B1 mRNA]]; NR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA]]; NR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of UGT1A1 mRNA]]; NR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in increased abundance of Bile Acids and Salts]]; oltipraz inhibits the reaction [Lithocholic Acid affects the localization of and results in increased activity of NR1I3 protein]; Phenobarbital inhibits the reaction [Lithocholic Acid inhibits the reaction [NR1I3 protein results in increased expression of NR1H4 mRNA]]; Phenobarbital promotes the reaction [Lithocholic Acid affects the localization of and results in increased activity of NR1I3 protein]; Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid affects the localization of and results in increased activity of NR1I3 protein]
CTD PMID:14742670, PMID:15358766, PMID:16929008, PMID:19196849, PMID:19433268, PMID:20359477, PMID:23015691 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 decreases expression EXP Lithocholic Acid results in decreased expression of NR5A2 mRNA CTD PMID:20888898 NCBI chr13:53,750,470...53,870,288
Ensembl chr13:53,750,473...53,870,428
JBrowse link
G Ocln occludin multiple interactions ISO Lithocholic Acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of OCLN protein]]; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of and affects the localization of OCLN protein]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of OCLN protein]] CTD PMID:31472180 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
JBrowse link
G Orm1 orosomucoid 1 increases expression ISO Lithocholic Acid results in increased expression of ORM1 mRNA CTD PMID:19000923 NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases activity
ISO 3-aminobenzamide inhibits the reaction [Lithocholic Acid analog results in increased activity of PARP1 protein] CTD PMID:2120135 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pctp phosphatidylcholine transfer protein decreases expression ISO Lithocholic Acid results in decreased expression of PCTP mRNA CTD PMID:20359477 NCBI chr10:77,491,445...77,537,268
Ensembl chr10:77,491,454...77,512,032
JBrowse link
G Pcyt1b phosphate cytidylyltransferase 1, choline, beta increases expression
multiple interactions
ISO Lithocholic Acid results in increased expression of PCYT1B mRNA
SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of PCYT1B mRNA]
CTD PMID:21480330, PMID:23034213 NCBI chr  X:62,727,691...62,821,199
Ensembl chr  X:62,727,755...62,818,522
JBrowse link
G Pgk1 phosphoglycerate kinase 1 increases expression ISO Lithocholic Acid results in increased expression of PGK1 protein CTD PMID:21224350 NCBI chr  X:77,263,399...77,279,373
Ensembl chr  X:77,263,359...77,279,367
JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 increases expression ISO Lithocholic Acid results in increased expression of PIK3R5 mRNA CTD PMID:19000923 NCBI chr10:55,013,686...55,078,986
Ensembl chr10:55,013,703...55,080,421
JBrowse link
G Plaur plasminogen activator, urokinase receptor multiple interactions
increases expression
ISO [Lithocholic Acid results in increased activity of MAPK1 protein] which results in increased expression of PLAUR mRNA; [Lithocholic Acid results in increased activity of MAPK3 protein] which results in increased expression of PLAUR mRNA; MAP2K1 protein promotes the reaction [Lithocholic Acid results in increased expression of PLAUR mRNA]; MAPK1 protein promotes the reaction [Lithocholic Acid results in increased expression of PLAUR mRNA] CTD PMID:19782465 NCBI chr 1:81,328,171...81,344,954
Ensembl chr 1:81,328,183...81,344,708
JBrowse link
G Pld1 phospholipase D1 increases expression
multiple interactions
ISO Lithocholic Acid results in increased expression of PLD1 mRNA
SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of PLD1 mRNA]
CTD PMID:21480330, PMID:23034213 NCBI chr 2:113,651,967...113,849,403
Ensembl chr 2:113,652,348...113,849,403
JBrowse link
G Pld2 phospholipase D2 increases expression
multiple interactions
ISO Lithocholic Acid results in increased expression of PLD2 mRNA
SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of PLD2 mRNA]
CTD PMID:21480330, PMID:23034213 NCBI chr10:57,161,921...57,181,148
Ensembl chr10:57,163,174...57,179,730
JBrowse link
G Plpp1 phospholipid phosphatase 1 increases expression ISO Lithocholic Acid results in increased expression of PLPP1 mRNA CTD PMID:20359477 NCBI chr 2:44,664,076...44,726,820
Ensembl chr 2:44,664,124...44,726,689
JBrowse link
G Plpp2 phospholipid phosphatase 2 increases expression ISO Lithocholic Acid results in increased expression of PLPP2 mRNA CTD PMID:20359477 NCBI chr 7:13,062,168...13,070,281
Ensembl chr 7:13,062,196...13,070,280
JBrowse link
G Plscr1 phospholipid scramblase 1 multiple interactions
increases expression
ISO Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased expression of PLSCR1 mRNA] CTD PMID:20359477 NCBI chr 8:99,625,523...99,645,882
Ensembl chr 8:99,625,545...99,725,217
JBrowse link
G Polb DNA polymerase beta multiple interactions EXP Lithocholic Acid analog binds to and results in decreased activity of POLB protein; Lithocholic Acid binds to and results in decreased activity of POLB protein; Lithocholic Acid binds to and results in decreased activity of POLB protein mutant form CTD PMID:15311928, PMID:15656580, PMID:16996474 NCBI chr16:74,237,001...74,260,272
Ensembl chr16:74,237,001...74,260,271
JBrowse link
G Por cytochrome p450 oxidoreductase increases abundance ISO POR gene mutant form results in increased abundance of Lithocholic Acid CTD PMID:25034404 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression
multiple interactions
ISO Lithocholic Acid results in decreased expression of PPARA mRNA
[PPARA protein co-treated with CREB1 protein] promotes the reaction [Lithocholic Acid results in increased expression of PTGS2 mRNA]
[Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of PPARA mRNA
CTD PMID:18648741, PMID:20359477 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Prkcb protein kinase C, beta increases activity ISO Lithocholic Acid results in increased activity of PRKCB protein CTD PMID:7705931 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Psmb4 proteasome 20S subunit beta 4 decreases expression
affects expression
EXP Lithocholic Acid results in decreased expression of PSMB4 mRNA
Lithocholic Acid affects the expression of PSMB4 mRNA
CTD PMID:18246545 NCBI chr 2:196,043,546...196,046,320
Ensembl chr 2:196,043,618...196,046,311
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO [PPARA protein co-treated with CREB1 protein] promotes the reaction [Lithocholic Acid results in increased expression of PTGS2 mRNA]; [SLCO1B3 protein results in increased transport of Lithocholic Acid] which results in increased expression of PTGS2 mRNA CTD PMID:18648741 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions ISO Lithocholic Acid results in decreased phosphorylation of and results in decreased activity of PTK2 protein CTD PMID:21224350 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Pxn paxillin multiple interactions ISO Lithocholic Acid results in decreased phosphorylation of and results in decreased activity of PXN protein CTD PMID:21224350 NCBI chr12:46,797,953...46,845,107
Ensembl chr12:46,797,954...46,845,080
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions
increases expression
ISO Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in increased expression of PYCARD mRNA]; Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in increased expression of PYCARD protein]
Lithocholic Acid results in increased expression of PYCARD mRNA; Lithocholic Acid results in increased expression of PYCARD protein
CTD PMID:29794447 NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210
JBrowse link
G Rab12 RAB12, member RAS oncogene family affects binding EXP Lithocholic Acid binds to RAB12 protein CTD PMID:18641422 NCBI chr 9:114,683,985...114,709,613
Ensembl chr 9:114,684,039...114,709,546
JBrowse link
G Rab3a RAB3A, member RAS oncogene family affects binding EXP Lithocholic Acid binds to RAB3A protein CTD PMID:18641422 NCBI chr16:20,435,098...20,439,206
Ensembl chr16:20,435,101...20,439,206
JBrowse link
G Rab3d RAB3D, member RAS oncogene family affects binding EXP Lithocholic Acid binds to RAB3D protein CTD PMID:18641422 NCBI chr 8:22,920,238...22,929,368
Ensembl chr 8:22,918,699...22,929,294
JBrowse link
G Rangap1 RAN GTPase activating protein 1 increases phosphorylation ISO Lithocholic Acid results in increased phosphorylation of RANGAP1 protein CTD PMID:21224350 NCBI chr 7:122,939,266...122,967,178
Ensembl chr 7:122,940,376...122,967,178
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Lithocholic Acid inhibits the reaction [IL1B protein results in increased phosphorylation of RELA protein]; Lithocholic Acid inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]] CTD PMID:18515093, PMID:31472180 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rnh1 ribonuclease/angiogenin inhibitor 1 increases expression ISO Lithocholic Acid results in increased expression of RNH1 protein CTD PMID:21224350 NCBI chr 1:214,151,341...214,163,807
Ensembl chr 1:214,151,338...214,163,808
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO
EXP
Lithocholic Acid promotes the reaction [VDR protein binds to RXRA protein]
[NR1I2 protein co-treated with RXRA protein] promotes the reaction [Lithocholic Acid results in increased expression of SULT2A1 mRNA]
CTD PMID:12370413, PMID:15578590, PMID:15824121, PMID:20153625, PMID:21917910 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Rxrb retinoid X receptor beta affects binding ISO Lithocholic Acid binds to RXRB protein CTD PMID:11939783 NCBI chr20:3,822,673...3,829,138
Ensembl chr20:3,823,042...3,829,140
JBrowse link
G S100g S100 calcium binding protein G increases expression ISO
EXP
Lithocholic Acid results in increased expression of S100G mRNA CTD PMID:15824121, PMID:17535892 NCBI chr  X:33,442,820...33,445,714
Ensembl chr  X:33,443,186...33,445,709
JBrowse link
G Scarb1 scavenger receptor class B, member 1 decreases expression
increases expression
ISO Lithocholic Acid results in decreased expression of SCARB1 mRNA; Lithocholic Acid results in decreased expression of SCARB1 protein
Lithocholic Acid results in increased expression of SCARB1 mRNA
CTD PMID:15883047, PMID:19000923 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions
decreases expression
ISO Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of SCD1 mRNA] CTD PMID:20359477, PMID:21480330 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Sgms1 sphingomyelin synthase 1 increases expression ISO Lithocholic Acid results in increased expression of SGMS1 mRNA CTD PMID:21480330 NCBI chr 1:250,692,448...250,951,685
Ensembl chr 1:250,691,370...250,951,697
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of SIRT1 protein]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of SIRT1 protein]] CTD PMID:31472180 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions
decreases expression
ISO [Lithocholic Acid co-treated with 1,4-bis(2-(3,5-dichloropyridyloxy))benzene] results in increased expression of SLC10A1 mRNA; NR1H3 protein inhibits the reaction [Lithocholic Acid results in decreased expression of SLC10A1 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in decreased expression of SLC10A1 mRNA]
Lithocholic Acid results in decreased expression of SLC10A1 mRNA; Lithocholic Acid results in decreased expression of SLC10A1 protein
CTD PMID:12637555, PMID:16436656, PMID:17256725, PMID:18032408, PMID:20977460, PMID:23034213, PMID:25582706 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
JBrowse link
G Slc10a2 solute carrier family 10 member 2 multiple interactions
increases expression
ISO NR1H3 protein inhibits the reaction [Lithocholic Acid results in increased expression of SLC10A2 mRNA] CTD PMID:17256725, PMID:25582706 NCBI chr16:90,324,420...90,350,254
Ensembl chr16:90,324,361...90,345,865
JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression ISO Lithocholic Acid results in increased expression of SLC2A1 mRNA CTD PMID:19000923 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Slc51a solute carrier family 51 subunit alpha multiple interactions
increases expression
EXP
ISO
[Lithocholic Acid binds to VDR protein] which affects the expression of SLC51A mRNA
Lithocholic Acid results in increased expression of SLC51A mRNA
Lithocholic Acid inhibits the reaction [NR1H3 protein results in increased expression of SLC51A mRNA]
CTD PMID:17256725, PMID:19562681, PMID:25055961, PMID:25582706 NCBI chr11:71,533,078...71,547,476
Ensembl chr11:71,533,078...71,547,476
JBrowse link
G Slc51b solute carrier family 51 subunit beta multiple interactions
increases expression
ISO
EXP
NR1H3 protein inhibits the reaction [Lithocholic Acid results in increased expression of SLC51B mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of SLC51B mRNA]
[Lithocholic Acid binds to VDR protein] which affects the expression of SLC51B mRNA
CTD PMID:17256725, PMID:19562681, PMID:23034213, PMID:25055961 NCBI chr 8:70,930,196...70,938,559
Ensembl chr 8:70,930,347...70,932,986
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 increases expression ISO Lithocholic Acid results in increased expression of SLCO1A4 mRNA CTD PMID:23034213 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases expression
increases transport
increases expression
increases uptake
multiple interactions
ISO Lithocholic Acid results in decreased expression of SLCO1B2 mRNA
SLCO1B3 protein results in increased transport of Lithocholic Acid
Lithocholic Acid results in increased expression of SLCO1B3 mRNA
SLCO1B3 protein results in increased uptake of Lithocholic Acid
[SLCO1B3 protein results in increased transport of Lithocholic Acid] which results in increased expression of PTGS2 mRNA
Lithocholic Acid results in increased expression of SLCO1B2 mRNA
Lithocholic Acid inhibits the reaction [NR1H3 protein results in increased expression of SLCO1B2 mRNA]
CTD PMID:12637555, PMID:16534140, PMID:17256725, PMID:18648741, PMID:25055961, PMID:25582706 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Smad3 SMAD family member 3 multiple interactions
increases response to substance
ISO SMAD3 protein promotes the reaction [Lithocholic Acid results in decreased expression of SLC10A1 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC1 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC4 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of CHKA mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT1 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT2 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT4 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of PCYT1B mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of PLD1 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of PLD2 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of SLC51B mRNA]
SMAD3 protein results in increased susceptibility to Lithocholic Acid
CTD PMID:23034213 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 increases expression ISO Lithocholic Acid results in increased expression of SMPD3 mRNA CTD PMID:21480330 NCBI chr19:38,237,963...38,321,572
Ensembl chr19:38,237,965...38,321,528
JBrowse link
G Sod1 superoxide dismutase 1 increases expression EXP Lithocholic Acid results in increased expression of SOD1 mRNA CTD PMID:21311750 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sptlc1 serine palmitoyltransferase, long chain base subunit 1 increases expression ISO Lithocholic Acid results in increased expression of SPTLC1 mRNA CTD PMID:21480330 NCBI chr17:11,856,525...11,895,566
Ensembl chr17:11,856,525...11,895,566
JBrowse link
G Sptlc2 serine palmitoyltransferase, long chain base subunit 2 increases expression ISO Lithocholic Acid results in increased expression of SPTLC2 mRNA CTD PMID:21480330 NCBI chr 6:111,334,408...111,417,960
Ensembl chr 6:111,339,136...111,417,954
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
decreases expression
ISO Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of SREBF1 mRNA] CTD PMID:20359477 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G St3gal1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 multiple interactions ISO Lithocholic Acid analog results in decreased expression of and results in decreased activity of ST3GAL1 protein CTD PMID:21224350 NCBI chr 7:107,895,045...107,963,158
Ensembl chr 7:107,895,045...107,963,142
JBrowse link
G St3gal3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 decreases activity ISO Lithocholic Acid analog results in decreased activity of ST3GAL3 protein CTD PMID:21224350 NCBI chr 5:136,765,309...136,965,642
Ensembl chr 5:136,766,208...136,965,191
JBrowse link
G St3gal4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 increases phosphorylation ISO Lithocholic Acid results in increased phosphorylation of ST3GAL4 protein CTD PMID:21224350 NCBI chr 8:36,264,741...36,314,811
Ensembl chr 8:36,264,750...36,314,811
JBrowse link
G St6gal1 ST6 beta-galactoside alpha-2,6-sialyltransferase 1 decreases activity ISO Lithocholic Acid analog results in decreased activity of ST6GAL1 protein CTD PMID:21224350 NCBI chr11:80,927,601...80,981,424
Ensembl chr11:80,927,601...80,981,422
JBrowse link
G Stim1 stromal interaction molecule 1 affects localization EXP Lithocholic Acid affects the localization of STIM1 protein CTD PMID:18342630 NCBI chr 1:167,373,894...167,533,412
Ensembl chr 1:167,373,678...167,533,420
JBrowse link
G Stmn1 stathmin 1 increases expression ISO Lithocholic Acid results in increased expression of STMN1 mRNA CTD PMID:19000923 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases sulfation
multiple interactions
increases expression
ISO
EXP
SULT2A1 protein results in increased sulfation of Lithocholic Acid
[Cyclosporine results in decreased activity of SULT2A1 protein] which results in increased abundance of Lithocholic Acid
[NR1I2 protein co-treated with RXRA protein] promotes the reaction [Lithocholic Acid results in increased expression of SULT2A1 mRNA]
CTD PMID:12370413, PMID:20102295, PMID:21839837, PMID:26198044 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230
JBrowse link
G Tfrc transferrin receptor increases expression ISO Lithocholic Acid results in increased expression of TFRC mRNA CTD PMID:19000923 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions
ISO Lithocholic Acid results in increased expression of TGFB1 mRNA
EGF protein promotes the reaction [Lithocholic Acid results in increased activity of TGFB1 protein]
NR1H4 protein promotes the reaction [Lithocholic Acid results in increased expression of TGFB1 mRNA]
CTD PMID:19646460, PMID:21480330, PMID:23034213 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 increases expression ISO Lithocholic Acid results in increased expression of TGFBR1 mRNA CTD PMID:23034213 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 increases expression ISO Lithocholic Acid results in increased expression of TGFBR2 mRNA CTD PMID:23034213 NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO Lithocholic Acid results in increased expression of TIMP1 mRNA CTD PMID:16436656 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO Lithocholic Acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of TJP1 protein]]; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of and affects the localization of TJP1 protein]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of TJP1 protein]] CTD PMID:31472180 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO Lithocholic Acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of CDH1 protein]]; Lithocholic Acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of CLDN1 protein]]; Lithocholic Acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of OCLN protein]]; Lithocholic Acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of TJP1 protein]]; Lithocholic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of and affects the localization of CDH1 protein]; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of and affects the localization of CLDN1 protein]; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of and affects the localization of NFE2L2 protein]; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of and affects the localization of OCLN protein]; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of and affects the localization of TJP1 protein]; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of HMOX1 protein]; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of SIRT1 protein]; Lithocholic Acid inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Lithocholic Acid inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein]; Lithocholic Acid inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; TNF protein promotes the reaction [Lithocholic Acid results in increased expression of CASP3 protein]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of CDH1 protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of CLDN1 protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of HMOX1 protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of NFE2L2 protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of OCLN protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of SIRT1 protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of TJP1 protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]]; VDR protein promotes the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]
Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in increased expression of TNF protein]
Lithocholic Acid results in increased expression of TNF mRNA; Lithocholic Acid results in increased expression of TNF protein
CTD PMID:18515093, PMID:21480330, PMID:23566200, PMID:23627780, PMID:29794447, PMID:31472180 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO Lithocholic Acid inhibits the reaction [Vitamin D results in increased expression of TNFSF11 mRNA] CTD PMID:20055894 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Trap1 TNF receptor-associated protein 1 decreases expression ISO Lithocholic Acid results in decreased expression of TRAP1 protein CTD PMID:21224350 NCBI chr10:11,724,032...11,757,682
Ensembl chr10:11,724,032...11,757,681
JBrowse link
G Trpv6 transient receptor potential cation channel, subfamily V, member 6 multiple interactions
increases expression
ISO
EXP
[Lithocholic Acid analog binds to and results in increased activity of VDR protein] which results in increased expression of TRPV6 mRNA; [Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of TRPV6 mRNA
Lithocholic Acid results in increased expression of TRPV6 mRNA
CTD PMID:15489543, PMID:17535892, PMID:18180267 NCBI chr 4:70,918,631...70,934,291
Ensembl chr 4:70,918,632...70,934,295
JBrowse link
G Txn1 thioredoxin 1 multiple interactions
increases expression
ISO [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of TXN mRNA
[Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of TXN1 mRNA
Lithocholic Acid results in increased expression of TXN protein
CTD PMID:17724089 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression
multiple interactions
ISO Lithocholic Acid results in increased expression of TXNRD1 mRNA; Lithocholic Acid results in increased expression of TXNRD1 protein
[Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of TXNRD1 mRNA
NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of TXNRD1 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of TXNRD1 protein]
CTD PMID:17724089, PMID:20977460 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions
decreases expression
ISO 1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of UGT1A1 mRNA]; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of UGT1A1 mRNA]]; NR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of UGT1A1 mRNA]]; Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of UGT1A1 mRNA] CTD PMID:19196849 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases expression ISO Lithocholic Acid results in increased expression of UGT1A3 mRNA CTD PMID:20189675 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b UDP glycosyltransferase 2 family, polypeptide B increases glucuronidation EXP UGT2B protein results in increased glucuronidation of Lithocholic Acid CTD PMID:2429951 Ensembl chr14:22,375,955...22,534,720 JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 multiple interactions EXP [Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of UGT2B15 mRNA CTD PMID:21311750 NCBI chr14:22,375,428...22,486,291
Ensembl chr14:22,375,955...22,534,720
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases expression EXP Lithocholic Acid results in increased expression of UGT2B17 mRNA CTD PMID:21311750 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO [Lithocholic Acid promotes the reaction [NR1H4 protein binds to UGT2B7 promoter]] which results in decreased expression of UGT2B7 mRNA; Lithocholic Acid promotes the reaction [NR1H4 protein binds to UGT2B7 promoter] CTD PMID:15821044 NCBI chr14:22,597,103...22,619,968 JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression ISO Lithocholic Acid results in increased expression of VCAM1 mRNA; Lithocholic Acid results in increased expression of VCAM1 protein CTD PMID:16582018 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vdr vitamin D receptor multiple interactions
affects binding
increases phosphorylation
increases activity
increases expression
decreases expression
ISO
EXP
Lithocholic Acid binds to and results in increased activity of VDR protein; Lithocholic Acid binds to and results in increased activity of VDR protein mutant form; Lithocholic Acid promotes the reaction [VDR protein binds to RXRA protein]; VDR protein promotes the reaction [Lithocholic Acid results in increased expression of CYP3A4 mRNA]; VDR protein promotes the reaction [Lithocholic Acid results in increased expression of CYP3A4 protein]
Lithocholic Acid analog binds to VDR protein; Lithocholic Acid binds to VDR protein; Lithocholic Acid binds to VDR protein mutant form
Lithocholic Acid results in increased phosphorylation of VDR protein
[Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA; [Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of KLK6 mRNA; [Lithocholic Acid binds to VDR protein] which affects the expression of SLC51A mRNA; [Lithocholic Acid binds to VDR protein] which affects the expression of SLC51B mRNA; [Lithocholic Acid binds to VDR protein] which results in increased expression of NR0B2 mRNA; Lithocholic Acid binds to and results in increased activity of VDR protein
Lithocholic Acid metabolite results in increased activity of VDR protein; Lithocholic Acid results in increased activity of VDR protein
[Lithocholic Acid analog binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA; [Lithocholic Acid analog binds to and results in increased activity of VDR protein] which results in increased expression of TRPV6 mRNA; [Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of CAMP mRNA; [Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of CDH1 mRNA; [Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA; [Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of CYP3A4 mRNA; [Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of TRPV6 mRNA; [Lithocholic Acid binds to VDR protein] which results in decreased activity of CTNNB1 mRNA; HR protein inhibits the reaction [Lithocholic Acid results in increased activity of VDR protein]; Lithocholic Acid analog binds to and results in increased activity of VDR protein; Lithocholic Acid binds to and results in increased activity of and results in increased localization of VDR protein; Lithocholic Acid binds to and results in increased activity of VDR protein; Lithocholic Acid binds to and results in increased activity of VDR protein mutant form; Lithocholic Acid inhibits the reaction [1,25-dihydroxy-26,27-dimethylcholecalciferol binds to VDR protein]; Lithocholic Acid inhibits the reaction [VDR protein binds to NCOR1 protein]; Lithocholic Acid inhibits the reaction [VDR protein binds to NCOR2 protein]; Lithocholic Acid promotes the reaction [VDR protein binds to CYP24A1 promoter]; Lithocholic Acid promotes the reaction [VDR protein binds to HR protein]; Lithocholic Acid promotes the reaction [VDR protein binds to NCOA1 protein]; Lithocholic Acid promotes the reaction [VDR protein binds to NCOR2 protein]; Lithocholic Acid promotes the reaction [VDR protein binds to RXRA protein]; Lithocholic Acid results in increased expression of and results in increased activity of VDR protein; Lithocholic Acid results in increased localization of [VDR protein co-treated with CAV1 protein]; trichostatin A inhibits the reaction [HR protein inhibits the reaction [Lithocholic Acid results in increased activity of VDR protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of CDH1 protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of CLDN1 protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of HMOX1 protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of NFE2L2 protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of OCLN protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of SIRT1 protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of TJP1 protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]]; VDR protein promotes the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]; VDR protein promotes the reaction [Lithocholic Acid results in increased expression of ABCB1 mRNA]; VDR protein promotes the reaction [Lithocholic Acid results in increased expression of CYP3A4 mRNA]
Lithocholic Acid results in increased expression of VDR mRNA; Lithocholic Acid results in increased expression of VDR protein
Lithocholic Acid results in decreased expression of VDR mRNA
CTD PMID:14525957, PMID:15489543, PMID:15578590, PMID:15824121, PMID:17963371, PMID:18180267, PMID:18515093, PMID:18645036, PMID:19460946, PMID:19562681, PMID:19646460, PMID:19733911, PMID:20006981, PMID:20043299, PMID:20153625, PMID:20371703, PMID:20435140, PMID:21291553, PMID:21311750, PMID:21397016, PMID:21543282, PMID:21917910, PMID:22466564, PMID:23723390, PMID:27871908, PMID:31472180 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO Lithocholic Acid results in increased expression of VEGFA mRNA CTD PMID:19000923 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Wdr1 WD repeat domain 1 decreases expression ISO Lithocholic Acid results in decreased expression of WDR1 protein CTD PMID:21224350 NCBI chr14:76,990,014...77,023,739
Ensembl chr14:76,989,919...77,023,726
JBrowse link
G Zeb2 zinc finger E-box binding homeobox 2 increases expression ISO Lithocholic Acid results in increased expression of ZEB2 mRNA CTD PMID:19000923 NCBI chr 3:29,857,289...29,985,932
Ensembl chr 3:29,862,473...29,996,865
JBrowse link
lithocholic acid sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO sulfolithocholic acid inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein] CTD PMID:16101123 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Gsta4 glutathione S-transferase alpha 4 multiple interactions EXP sulfolithocholic acid binds to and results in decreased activity of GSTA4 protein CTD PMID:3954743 NCBI chr 8:85,497,557...85,514,732
Ensembl chr 8:85,497,557...85,518,879
JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions EXP sulfolithocholic acid binds to and results in decreased activity of GSTM1 protein CTD PMID:3954743 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstm2 glutathione S-transferase mu 2 multiple interactions EXP sulfolithocholic acid binds to and results in decreased activity of GSTM2 protein CTD PMID:3954743 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
sulfoglycolithocholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc10a1 solute carrier family 10 member 1 increases uptake ISO SLC10A1 protein results in increased uptake of sulfolithocholylglycine CTD PMID:29024779 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
JBrowse link
taurolithocholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 affects localization
multiple interactions
decreases activity
EXP
ISO
Taurolithocholic Acid affects the localization of ABCB11 protein
Taurolithocholic Acid affects the localization of and affects the activity of ABCB11 protein
Taurolithocholic Acid inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Taurolithocholic Acid results in decreased activity of ABCB11 protein
CTD PMID:12865277, PMID:15763547, PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects localization
multiple interactions
EXP Taurolithocholic Acid affects the localization of ABCC2 protein
3-chloroacetylindole inhibits the reaction [Taurolithocholic Acid results in decreased activity of ABCC2 protein]; [Colchicine co-treated with JTE 013] inhibits the reaction [Taurolithocholic Acid results in decreased activity of ABCC2 protein]; CYM-5520 inhibits the reaction [Taurolithocholic Acid results in decreased activity of ABCC2 protein]; Dideoxyadenosine inhibits the reaction [Taurolithocholic Acid affects the localization of ABCC2 protein]; Dideoxyadenosine inhibits the reaction [Taurolithocholic Acid results in decreased activity of ABCC2 protein]; JTE 013 inhibits the reaction [Taurolithocholic Acid affects the localization of ABCC2 protein]; JTE 013 inhibits the reaction [Taurolithocholic Acid results in decreased activity of ABCC2 protein]; JTE 013 inhibits the reaction [Taurolithocholic Acid results in decreased activity of and affects the localization of ABCC2 protein]; KT 5720 inhibits the reaction [Taurolithocholic Acid results in decreased activity of and affects the localization of ABCC2 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Taurolithocholic Acid results in decreased activity of ABCC2 protein]; RMI 12330A inhibits the reaction [Taurolithocholic Acid results in decreased activity of and affects the localization of ABCC2 protein]; S1PR2 protein affects the reaction [Taurolithocholic Acid results in decreased activity of ABCC2 protein]; Taurolithocholic Acid results in decreased activity of and affects the localization of ABCC2 protein; Wortmannin inhibits the reaction [Taurolithocholic Acid results in decreased activity of and affects the localization of ABCC2 protein]
CTD PMID:31300867 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
EXP Taurolithocholic Acid results in increased phosphorylation of AKT1 protein
JTE 013 inhibits the reaction [Taurolithocholic Acid results in increased phosphorylation of AKT1 protein]; KT 5720 inhibits the reaction [Taurolithocholic Acid results in increased phosphorylation of AKT1 protein]; RMI 12330A inhibits the reaction [Taurolithocholic Acid results in increased phosphorylation of AKT1 protein]; S1PR2 protein affects the reaction [Taurolithocholic Acid results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Taurolithocholic Acid results in increased phosphorylation of AKT1 protein]
CTD PMID:31300867 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 multiple interactions
affects binding
ISO [Taurolithocholic Acid binds to and affects the activity of CHRM3 protein] which results in increased abundance of Inositol Phosphates; Taurolithocholic Acid binds to and affects the activity of CHRM3 protein
Taurolithocholic Acid binds to CHRM3 protein
CTD PMID:12379313, PMID:12464352 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
ISO Taurolithocholic Acid results in increased expression of FOS mRNA
tauroursodeoxycholic acid inhibits the reaction [Taurolithocholic Acid results in increased expression of FOS mRNA]
CTD PMID:18164257 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 increases abundance ISO HSD11B1 gene mutant form results in increased abundance of Taurolithocholic Acid CTD PMID:25061560 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
ISO Taurolithocholic Acid results in increased expression of JUN mRNA
tauroursodeoxycholic acid inhibits the reaction [Taurolithocholic Acid results in increased expression of JUN mRNA]
CTD PMID:18164257 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Por cytochrome p450 oxidoreductase increases abundance ISO POR gene mutant form results in increased abundance of Taurolithocholic Acid CTD PMID:25034404 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha increases activity
multiple interactions
EXP Taurolithocholic Acid results in increased activity of PRKACA protein
JTE 013 inhibits the reaction [Taurolithocholic Acid results in increased activity of PRKACA protein]; KT 5720 inhibits the reaction [Taurolithocholic Acid results in increased activity of PRKACA protein]; RMI 12330A inhibits the reaction [Taurolithocholic Acid results in increased activity of PRKACA protein]
CTD PMID:31300867 NCBI chr19:25,095,089...25,118,869
Ensembl chr19:25,095,089...25,118,860
JBrowse link
G S1pr2 sphingosine-1-phosphate receptor 2 multiple interactions EXP S1PR2 protein affects the reaction [Taurolithocholic Acid results in decreased activity of ABCC2 protein]; S1PR2 protein affects the reaction [Taurolithocholic Acid results in increased phosphorylation of AKT1 protein] CTD PMID:31300867 NCBI chr 8:21,984,914...21,995,806
Ensembl chr 8:21,984,914...21,995,806
JBrowse link
G Smad3 SMAD family member 3 increases abundance ISO SMAD3 protein results in increased abundance of Taurolithocholic Acid CTD PMID:23034213 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
taurolithocholic acid sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions
decreases response to substance
EXP AGT protein inhibits the reaction [taurolithocholic acid 3-sulfate results in increased activity of CASP3 protein]
AGT protein results in decreased susceptibility to taurolithocholic acid 3-sulfate
CTD PMID:23300732 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
EXP AGT protein inhibits the reaction [taurolithocholic acid 3-sulfate results in increased activity of CASP3 protein] CTD PMID:23300732 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cftr CF transmembrane conductance regulator decreases activity ISO taurolithocholic acid 3-sulfate results in decreased activity of CFTR protein CTD PMID:15634668 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 affects binding ISO taurolithocholic acid 3-sulfate binds to CHRM1 protein CTD PMID:12464352 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Ifng interferon gamma multiple interactions
increases expression
ISO Dantrolene inhibits the reaction [taurolithocholic acid 3-sulfate results in increased expression of IFNG mRNA] CTD PMID:22517774 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO Dantrolene inhibits the reaction [taurolithocholic acid 3-sulfate results in increased expression of IL6 mRNA] CTD PMID:22517774 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      molecular entity 19782
        polyatomic entity 19695
          heteroatomic molecular entity 19620
            hydroxides 19066
              organic hydroxy compound 18630
                hydroxy-5beta-cholanic acid 915
                  monohydroxy-5beta-cholanic acid 261
                    12alpha-hydroxy-3-oxo-5beta-cholan-24-oic acid + 0
                    3-deoxychenodeoxycholic acid 0
                    3beta-hydroxy-7-oxo-5beta-cholan-24-oic acid 0
                    7,12-dioxolithocholic acid 0
                    7-oxolithocholic acid + 1
                    7alpha-hydroxy-3-oxo-5beta-cholan-24-oic acid 0
                    isolithocholic acid 0
                    lithocholic acid + 261
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic polycyclic compound 16384
                                  steroid 12788
                                    steroid fundamental parent 12403
                                      cholane 916
                                        cholanoid 916
                                          cholanic acids 915
                                            cholanic acid 915
                                              5beta-cholanic acid 915
                                                hydroxy-5beta-cholanic acid 915
                                                  monohydroxy-5beta-cholanic acid 261
                                                    12alpha-hydroxy-3-oxo-5beta-cholan-24-oic acid + 0
                                                    3-deoxychenodeoxycholic acid 0
                                                    3beta-hydroxy-7-oxo-5beta-cholan-24-oic acid 0
                                                    7,12-dioxolithocholic acid 0
                                                    7-oxolithocholic acid + 1
                                                    7alpha-hydroxy-3-oxo-5beta-cholan-24-oic acid 0
                                                    isolithocholic acid 0
                                                    lithocholic acid + 261
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.