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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dicarboxylic acid monoester
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Accession:CHEBI:36244 term browser browse the term
Definition:A monoester of a dicarboxylic acid.
Synonyms:related_synonym: dicarboxylic acid monoesters
 cyclic_relationship: is_conjugate_acid_of CHEBI:131605


show annotations for term's descendants           Sort by:
artesunate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions		 ISO Artesunate results in decreased expression of ACTA2 mRNA; Artesunate results in decreased expression of ACTA2 protein
Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]
Deferoxamine inhibits the reaction [Artesunate results in decreased expression of ACTA2 mRNA]		 CTD PMID:30551460 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects localization ISO artesunate affects the localization of AIFM1 protein CTD PMID:24704559 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Ar androgen receptor multiple interactions ISO artesunate binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Atg12 autophagy related 12 increases expression ISO Artesunate results in increased expression of ATG12 mRNA CTD PMID:30551460 NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418 		JBrowse link
G Atg3 autophagy related 3 increases expression ISO Artesunate results in increased expression of ATG3 mRNA CTD PMID:30551460 NCBI chr11:55,624,928...55,653,212
Ensembl chr11:55,624,917...55,653,224 		JBrowse link
G Atg5 autophagy related 5 increases expression ISO Artesunate results in increased expression of ATG5 mRNA CTD PMID:30551460 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 EXP
ISO		 [1,2-Dimethylhydrazine co-treated with artesunate] results in increased expression of BAX protein
Artesunate results in increased expression of BAX protein		 CTD PMID:24704559 PMID:29031619 PMID:33002460 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 EXP
ISO		 [1,2-Dimethylhydrazine co-treated with artesunate] results in decreased expression of BCL2 protein
3-methyladenine inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; acadesine promotes the reaction [Artesunate results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; dorsomorphin inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; Sirolimus promotes the reaction [Artesunate results in decreased expression of BCL2 protein]		 CTD PMID:24704559 PMID:29031619 PMID:33002460 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bst1 bone marrow stromal cell antigen 1 increases response to substance ISO BST1 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr14:67,253,706...67,270,203
Ensembl chr14:67,252,998...67,270,180 		JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
multiple interactions		 ISO artesunate results in increased activity of CASP3 protein
Artesunate results in increased cleavage of CASP3 protein
3-methyladenine inhibits the reaction [Artesunate results in increased cleavage of CASP3 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Artesunate results in increased cleavage of CASP3 protein]; Sirolimus promotes the reaction [Artesunate results in increased cleavage of CASP3 protein]		 CTD PMID:19513562 PMID:24704559 PMID:33002460 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 affects expression ISO artesunate affects the expression of CASP9 protein CTD PMID:24704559 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase decreases response to substance
increases expression		 ISO CAT protein results in decreased susceptibility to artesunate
artesunate results in increased expression of CAT protein		 CTD PMID:19513562 PMID:20144594 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cct2 chaperonin containing TCP1 subunit 2 decreases response to substance ISO CCT2 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 7:52,692,725...52,705,478
Ensembl chr 7:52,692,725...52,706,944 		JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions
increases phosphorylation		 ISO APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK1 protein] CTD PMID:31664825 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions
increases phosphorylation		 ISO APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK2 protein] CTD PMID:31664825 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Clip4 CAP-GLY domain containing linker protein family, member 4 increases response to substance ISO CLIP4 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 6:23,616,280...23,697,625
Ensembl chr 6:23,616,281...23,677,874 		JBrowse link
G Coq8a coenzyme Q8A decreases response to substance ISO COQ8A mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr13:91,904,731...91,933,588
Ensembl chr13:91,904,739...91,931,431 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CTNNB1 protein] CTD PMID:29031619 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Dbh dopamine beta-hydroxylase increases response to substance ISO DBH mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248 		JBrowse link
G Des desmin multiple interactions
decreases expression		 ISO Deferoxamine inhibits the reaction [Artesunate results in decreased expression of DES mRNA]
Artesunate results in decreased expression of DES mRNA; Artesunate results in decreased expression of DES protein		 CTD PMID:30551460 NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO artesunate binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO artesunate results in increased expression of FAS protein CTD PMID:19513562 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Flna filamin A increases response to substance ISO FLNA mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr  X:152,007,758...152,034,266
Ensembl chr  X:152,007,758...152,031,052 		JBrowse link
G Fn1 fibronectin 1 decreases expression
multiple interactions		 ISO Artesunate results in decreased expression of FN1 mRNA; Artesunate results in decreased expression of FN1 protein
Deferoxamine inhibits the reaction [Artesunate results in decreased expression of FN1 mRNA]		 CTD PMID:30551460 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions
decreases expression		 ISO Chloroquine inhibits the reaction [Artesunate results in decreased expression of FTH1 mRNA]
Artesunate results in decreased expression of FTH1 mRNA; Artesunate results in decreased expression of FTH1 protein		 CTD PMID:30551460 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G Fzd7 frizzled class receptor 7 increases response to substance ISO FZD7 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 9:60,931,433...60,934,252
Ensembl chr 9:60,930,875...60,935,781 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit affects response to substance
decreases response to substance		 ISO GCLC mRNA affects the susceptibility to artesunate
GCLC mRNA results in decreased susceptibility to artesunate		 CTD PMID:15796179 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit decreases response to substance ISO GCLM mRNA results in decreased susceptibility to artesunate CTD PMID:15796179 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gpx4 glutathione peroxidase 4 decreases activity
multiple interactions		 ISO Artesunate results in decreased activity of GPX4 protein
Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of GPX4 protein]		 CTD PMID:30551460 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Gstm4 glutathione S-transferase mu 4 affects response to substance ISO GSTM4 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression ISO artesunate results in decreased expression of GSTP1 protein CTD PMID:19513562 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Gstt2 glutathione S-transferase theta 2 affects response to substance ISO GSTT2 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288 		JBrowse link
G Gstz1 glutathione S-transferase zeta 1 affects response to substance ISO GSTZ1 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284 		JBrowse link
G H2ax H2A.X variant histone increases phosphorylation
multiple interactions		 ISO Artesunate results in increased phosphorylation of H2AX protein
APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of H2AX protein]		 CTD PMID:31664825 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Artesunate inhibits the reaction [Ethanol results in increased expression of IL1B protein]; Artesunate inhibits the reaction [Glucose results in increased expression of IL1B mRNA]; Artesunate inhibits the reaction [Glucose results in increased secretion of IL1B protein] CTD PMID:27474069 PMID:30031708 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP Artesunate inhibits the reaction [Ethanol results in increased expression of IL6 protein]; Artesunate inhibits the reaction [Glucose results in increased expression of IL6 mRNA]; Artesunate inhibits the reaction [Glucose results in increased secretion of IL6 protein] CTD PMID:27474069 PMID:30031708 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgb1 integrin subunit beta 1 increases response to substance ISO ITGB1 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases lipidation		 ISO 3-methyladenine inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; acadesine promotes the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; dorsomorphin inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; Sirolimus promotes the reaction [Artesunate results in increased lipidation of MAP1LC3B protein] CTD PMID:33002460 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 affects response to substance ISO MGST3 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr13:79,526,541...79,547,479
Ensembl chr13:79,526,541...79,547,411 		JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions EXP artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MKI67 protein] CTD PMID:29031619 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression		 EXP
ISO		 artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MMP9 protein]
Artesunate results in decreased expression of MMP9 mRNA
Chloroquine inhibits the reaction [Artesunate results in decreased expression of MMP9 mRNA]		 CTD PMID:29031619 PMID:30551460 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP artesunate inhibits the reaction [Ethanol results in increased activity of MPO protein] CTD PMID:27474069 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase decreases response to substance ISO MTHFD2 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation		 ISO acadesine promotes the reaction [Artesunate results in decreased phosphorylation of MTOR protein]; Acetylcysteine inhibits the reaction [Artesunate results in decreased phosphorylation of MTOR protein]; dorsomorphin inhibits the reaction [Artesunate results in decreased phosphorylation of MTOR protein] CTD PMID:33002460 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions EXP artesunate inhibits the reaction [Glucose results in increased expression of MYD88 protein] CTD PMID:30031708 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Naca nascent polypeptide associated complex subunit alpha decreases response to substance ISO NACA mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 7:468,862...481,992
Ensembl chr 7:469,723...481,992 		JBrowse link
G Nckap1 NCK-associated protein 1 increases response to substance ISO NCKAP1 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 3:65,417,450...65,491,769
Ensembl chr 3:65,417,453...65,492,217 		JBrowse link
G Ncoa4 nuclear receptor coactivator 4 decreases expression
multiple interactions		 ISO Artesunate results in decreased expression of NCOA4 mRNA; Artesunate results in decreased expression of NCOA4 protein
Chloroquine inhibits the reaction [Artesunate results in decreased expression of NCOA4 mRNA]		 CTD PMID:30551460 NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641
Ensembl chr16:7,366,542...7,409,641 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization ISO artesunate affects the localization of NFE2L2 protein CTD PMID:26340163 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP artesunate inhibits the reaction [Glucose results in increased expression of NLRP3 protein] CTD PMID:30031708 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions		 ISO Artesunate results in increased cleavage of PARP1 protein
3-methyladenine inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; acadesine promotes the reaction [Artesunate results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; dorsomorphin inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; Sirolimus promotes the reaction [Artesunate results in increased cleavage of PARP1 protein]		 CTD PMID:24704559 PMID:33002460 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein] CTD PMID:29031619 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO artesunate binds to and results in increased activity of PGR protein CTD PMID:25752796 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Carbon Tetrachloride results in increased susceptibility to Artesunate] which results in increased expression of PTGS2 mRNA; [Carbon Tetrachloride results in increased susceptibility to Artesunate] which results in increased expression of PTGS2 protein CTD PMID:30551460 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP artesunate inhibits the reaction [Ethanol results in increased expression of RELA protein]; artesunate inhibits the reaction [Glucose results in increased phosphorylation of RELA protein] CTD PMID:27474069 PMID:30031708 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rpa2 replication protein A2 increases phosphorylation ISO Artesunate results in increased phosphorylation of RPA2 protein CTD PMID:31664825 NCBI chr 5:144,976,789...144,989,445
Ensembl chr 5:144,976,748...144,987,350 		JBrowse link
G Rpl41 ribosomal protein L41 decreases response to substance ISO RPL41 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 7:977,885...978,965 JBrowse link
G Rpl6 ribosomal protein L6 decreases response to substance ISO RPL6 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr12:35,347,493...35,352,011
Ensembl chr12:35,347,497...35,351,921 		JBrowse link
G Rpl7 ribosomal protein L7 decreases response to substance ISO RPL7 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 5:3,217,184...3,220,192 JBrowse link
G Rps12 ribosomal protein S12 decreases response to substance ISO RPS12 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 1:21,680,854...21,683,010
Ensembl chr 1:21,680,852...21,683,014 		JBrowse link
G Rps15a ribosomal protein S15a decreases response to substance ISO RPS15A mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 1:172,420,151...172,427,021
Ensembl chr 1:172,419,761...172,426,995 		JBrowse link
G Rps6 ribosomal protein S6 decreases response to substance ISO RPS6 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Slc25a19 solute carrier family 25 member 19 decreases response to substance ISO SLC25A19 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr10:100,853,554...100,867,517
Ensembl chr10:100,847,168...100,867,447 		JBrowse link
G Sp1 Sp1 transcription factor decreases expression ISO artesunate results in decreased expression of SP1 protein CTD PMID:19513562 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
decreases expression		 ISO Chloroquine inhibits the reaction [Artesunate results in decreased expression of SQSTM1 protein]
Artesunate results in decreased expression of SQSTM1 mRNA; Artesunate results in decreased expression of SQSTM1 protein		 CTD PMID:30551460 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Srsf2 serine and arginine rich splicing factor 2 decreases response to substance ISO SRSF2 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions
increases expression		 ISO Chloroquine inhibits the reaction [Artesunate results in increased expression of TIMP1 mRNA] CTD PMID:30551460 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP artesunate inhibits the reaction [Glucose results in increased expression of TLR4 protein] CTD PMID:30031708 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP artesunate inhibits the reaction [Ethanol results in increased expression of TNF protein]; artesunate inhibits the reaction [Glucose results in increased expression of TNF mRNA]; artesunate inhibits the reaction [Glucose results in increased secretion of TNF protein] CTD PMID:27474069 PMID:30031708 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions		 ISO Artesunate results in increased expression of TP53 protein
Artesunate inhibits the reaction [TPT1 protein binds to TP53 protein]		 CTD PMID:33259807 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 affects response to substance
multiple interactions		 ISO TPT1 protein affects the susceptibility to artesunate
Artesunate binds to and results in decreased expression of TPT1 protein; Artesunate inhibits the reaction [TPT1 protein binds to TP53 protein]		 CTD PMID:15878303 PMID:33259807 NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625 		JBrowse link
G Tufm Tu translation elongation factor, mitochondrial decreases response to substance ISO TUFM mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 1:181,073,788...181,077,395
Ensembl chr 1:181,073,788...181,077,395 		JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 multiple interactions
increases phosphorylation		 ISO acadesine promotes the reaction [Artesunate results in increased phosphorylation of ULK1 protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased phosphorylation of ULK1 protein]; dorsomorphin inhibits the reaction [Artesunate results in increased phosphorylation of ULK1 protein] CTD PMID:33002460 NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of VEGFA protein] CTD PMID:29031619 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Yy1 YY1 transcription factor decreases expression ISO artesunate results in decreased expression of YY1 protein CTD PMID:19513562 NCBI chr 6:127,706,739...127,731,907
Ensembl chr 6:127,707,596...127,732,747 		JBrowse link
G Zbtb4 zinc finger and BTB domain containing 4 increases response to substance ISO ZBTB4 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr10:54,480,698...54,501,492
Ensembl chr10:54,485,071...54,501,492 		JBrowse link
benazepril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases activity
affects response to substance		 ISO benazepril results in decreased activity of ACE protein
ACE gene polymorphism affects the susceptibility to benazepril		 CTD PMID:8359184 PMID:11007831 PMID:12652327 PMID:12848919 PMID:15498266 More... NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ace2 angiotensin I converting enzyme 2 affects response to substance
increases response to substance
multiple interactions		 ISO ACE2 gene SNP affects the susceptibility to benazepril
ACE2 gene SNP results in increased susceptibility to benazepril
[AGT gene polymorphism co-treated with ACE2 gene polymorphism] affects the susceptibility to benazepril		 CTD PMID:20559404 PMID:21449848 PMID:27121444 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP [irbesartan co-treated with benazepril] results in decreased expression of ACTA2 protein; benazepril inhibits the reaction [Doxorubicin results in increased expression of ACTA2 mRNA] CTD PMID:15149348 PMID:20493835 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Adrb2 adrenoceptor beta 2 affects response to substance ISO ADRB2 protein polymorphism affects the susceptibility to benazepril CTD PMID:15554460 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Ager advanced glycosylation end product-specific receptor decreases expression EXP benazepril results in decreased expression of AGER mRNA; benazepril results in decreased expression of AGER protein CTD PMID:19018797 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Agt angiotensinogen decreases expression
affects response to substance
multiple interactions		 ISO
EXP		 benazepril results in decreased expression of AGT protein; benazepril results in decreased expression of AGT protein modified form
AGT gene SNP affects the susceptibility to benazepril
benazepril inhibits the reaction [Doxorubicin results in increased expression of AGT protein modified form]; benazepril inhibits the reaction [Particulate Matter results in increased expression of AGT protein modified form]; benazepril inhibits the reaction [Streptozocin results in increased expression of AGT protein modified form]
[AGT gene polymorphism co-treated with ACE2 gene polymorphism] affects the susceptibility to benazepril; [AGT gene polymorphism co-treated with AGTR1 gene polymorphism] affects the susceptibility to benazepril; [benazepril co-treated with Valsartan] results in decreased expression of AGT protein modified form; Valsartan inhibits the reaction [benazepril results in decreased expression of AGT protein]		 CTD PMID:10515446 PMID:11501062 PMID:11798627 PMID:12676074 PMID:17177138 More... NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases expression
multiple interactions		 EXP
ISO		 benazepril results in decreased expression of AGTR1A mRNA; benazepril results in decreased expression of AGTR1A protein
[AGT gene polymorphism co-treated with AGTR1 gene polymorphism] affects the susceptibility to benazepril
benazepril inhibits the reaction [Doxorubicin results in increased expression of AGTR1 protein]		 CTD PMID:9596920 PMID:15157388 PMID:21449848 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor decreases expression
multiple interactions		 ISO benazepril results in decreased expression of AMBP protein
benazepril promotes the reaction [Losartan results in decreased expression of AMBP protein]; Losartan promotes the reaction [benazepril results in decreased expression of AMBP protein]		 CTD PMID:16303729 NCBI chr 5:76,568,094...76,578,416
Ensembl chr 5:76,568,094...76,578,331 		JBrowse link
G Apob apolipoprotein B multiple interactions ISO [Valsartan co-treated with benazepril] results in decreased expression of APOB protein; fluvastatin promotes the reaction [[Valsartan co-treated with benazepril] results in decreased expression of APOB protein] CTD PMID:20671225 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497 		JBrowse link
G Aqp1 aquaporin 1 multiple interactions EXP benazepril inhibits the reaction [Glucose results in increased expression of AQP1 mRNA] CTD PMID:11510275 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690 		JBrowse link
G Aqp4 aquaporin 4 multiple interactions EXP benazepril inhibits the reaction [Glucose results in increased expression of AQP4 mRNA] CTD PMID:11510275 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression EXP benazepril results in decreased expression of BAX protein CTD PMID:20026869 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP benazepril results in increased expression of BCL2 protein CTD PMID:20026869 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bdkrb2 bradykinin receptor B2 increases activity
multiple interactions		 ISO
EXP		 benazepril results in increased activity of BDKRB2 protein
[icatibant results in decreased activity of BDKRB2 protein] which results in decreased susceptibility to benazepril		 CTD PMID:15339989 PMID:16982965 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP benazepril inhibits the reaction [Estrogens deficiency results in increased expression of CCL2 protein]; benazepril inhibits the reaction [Ethylene Glycol results in increased expression of CCL2 protein] CTD PMID:16284884 PMID:19553526 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions EXP benazepril inhibits the reaction [Estrogens deficiency results in increased expression of CCL3 protein] CTD PMID:19553526 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions EXP benazepril inhibits the reaction [Ethylene Glycol results in increased expression of CCL5 protein] CTD PMID:16284884 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression EXP benazepril results in decreased expression of CCN2 mRNA CTD PMID:17121042 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Cd36 CD36 molecule increases expression EXP benazepril results in increased expression of CD36 mRNA CTD PMID:14871019 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Col4a1 collagen type IV alpha 1 chain decreases expression
multiple interactions		 EXP benazepril results in decreased expression of COL4A1 mRNA
benazepril inhibits the reaction [Streptozocin results in increased expression of COL4A1 mRNA]		 CTD PMID:11798618 PMID:16191423 NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions EXP benazepril inhibits the reaction [Estrogens deficiency results in increased expression of CXCL1 protein] CTD PMID:19553526 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 affects response to substance ISO CYP11B2 gene polymorphism affects the susceptibility to benazepril CTD PMID:16765146 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
G Edn1 endothelin 1 decreases expression
multiple interactions
increases activity		 EXP benazepril results in decreased expression of EDN1 mRNA; benazepril results in decreased expression of EDN1 protein
[Valsartan co-treated with benazepril] results in decreased expression of EDN1 protein
benazepril results in increased activity of EDN1 protein		 CTD PMID:7528292 PMID:11136700 PMID:16191423 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 increases expression EXP benazepril results in increased expression of EGLN3 mRNA CTD PMID:14871019 NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP benazepril inhibits the reaction [Doxorubicin results in increased expression of FAS protein]; benazepril promotes the reaction [Valsartan inhibits the reaction [Doxorubicin results in increased expression of FAS protein]]; Valsartan promotes the reaction [benazepril inhibits the reaction [Doxorubicin results in increased expression of FAS protein]] CTD PMID:15315341 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand multiple interactions EXP benazepril inhibits the reaction [Doxorubicin results in increased expression of FASLG protein]; benazepril promotes the reaction [Valsartan inhibits the reaction [Doxorubicin results in increased expression of FASLG protein]]; Valsartan promotes the reaction [benazepril inhibits the reaction [Doxorubicin results in increased expression of FASLG protein]] CTD PMID:15315341 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fn1 fibronectin 1 decreases expression
multiple interactions		 EXP benazepril results in decreased expression of FN1 mRNA; benazepril results in decreased expression of FN1 protein
benazepril inhibits the reaction [Doxorubicin results in increased expression of FN1 protein]; benazepril inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]		 CTD PMID:10515446 PMID:11798618 PMID:16191423 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP benazepril results in increased expression of FOS mRNA CTD PMID:8539265 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 increases expression EXP benazepril results in increased expression of GOT2 mRNA CTD PMID:14871019 NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994 		JBrowse link
G Hgf hepatocyte growth factor increases expression EXP benazepril results in increased expression of HGF mRNA CTD PMID:16696918 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 increases expression EXP benazepril results in increased expression of HSPE1 mRNA CTD PMID:14871019 NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP benazepril inhibits the reaction [Ethylene Glycol results in increased expression of IL6 protein] CTD PMID:16284884 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Kng2 kininogen 2 multiple interactions
increases expression		 EXP benazepril promotes the reaction [Valsartan results in increased expression of KNG1 protein modified form]; PD 123319 inhibits the reaction [benazepril promotes the reaction [Valsartan results in increased expression of KNG1 protein modified form]]; PD 123319 inhibits the reaction [Valsartan promotes the reaction [benazepril results in increased expression of KNG1 protein modified form]]; Valsartan promotes the reaction [benazepril results in increased expression of KNG1 protein modified form] CTD PMID:11509473 NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression EXP benazepril results in increased expression of MAPK1 mRNA CTD PMID:14871019 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Me1 malic enzyme 1 increases expression EXP benazepril results in increased expression of ME1 mRNA CTD PMID:14871019 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP benazepril inhibits the reaction [Doxorubicin results in decreased expression of MMP2 mRNA]; benazepril inhibits the reaction [Doxorubicin results in decreased expression of MMP2 protein]; benazepril inhibits the reaction [Streptozocin results in decreased expression of MMP2 mRNA]; benazepril inhibits the reaction [Streptozocin results in decreased expression of MMP2 protein] CTD PMID:16732983 PMID:19357873 PMID:20821936 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases activity
decreases expression
multiple interactions		 ISO
EXP		 benazepril results in increased activity of MMP9 protein
benazepril results in decreased expression of MMP9 protein
benazepril inhibits the reaction [Doxorubicin results in decreased expression of MMP9 mRNA]; benazepril inhibits the reaction [Doxorubicin results in decreased expression of MMP9 protein]		 CTD PMID:15339989 PMID:19357873 PMID:20981132 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase affects response to substance ISO MTHFR gene polymorphism affects the susceptibility to benazepril; MTHFR gene SNP affects the susceptibility to benazepril CTD PMID:16081343 PMID:20445573 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase affects response to substance ISO MTR gene SNP affects the susceptibility to benazepril; MTR protein polymorphism affects the susceptibility to benazepril CTD PMID:15148588 PMID:20445573 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression EXP benazepril results in increased expression of MYC mRNA CTD PMID:8539265 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Myh6 myosin heavy chain 6 multiple interactions EXP [Valsartan co-treated with benazepril] results in increased expression of MYH6 mRNA CTD PMID:11136700 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 decreases expression EXP benazepril results in decreased expression of NCF1 mRNA CTD PMID:19018797 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP benazepril inhibits the reaction [Ethylene Glycol results in increased expression of NFKB1 protein] CTD PMID:16284884 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP benazepril inhibits the reaction [Streptozocin results in decreased expression of NFKBIA mRNA] CTD PMID:17900838 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression EXP benazepril results in decreased expression of NOS2 mRNA; benazepril results in decreased expression of NOS2 protein CTD PMID:16191423 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nppa natriuretic peptide A multiple interactions
decreases expression		 EXP [Valsartan co-treated with benazepril] results in decreased expression of NPPA mRNA
benazepril results in decreased expression of NPPA mRNA		 CTD PMID:8763405 PMID:11136700 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B multiple interactions
decreases expression		 EXP [Valsartan co-treated with benazepril] results in decreased expression of NPPB mRNA
benazepril results in decreased expression of NPPB mRNA		 CTD PMID:11136700 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO benazepril inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression EXP benazepril results in decreased expression of PCNA protein CTD PMID:17121042 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression EXP benazepril results in increased expression of PDK4 mRNA CTD PMID:14871019 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850 		JBrowse link
G Pla2g5 phospholipase A2, group V decreases expression EXP benazepril results in decreased expression of PLA2G5 mRNA CTD PMID:14871019 NCBI chr 5:151,041,339...151,109,433
Ensembl chr 5:151,041,340...151,062,658 		JBrowse link
G Plau plasminogen activator, urokinase multiple interactions EXP benazepril inhibits the reaction [Streptozocin results in increased expression of PLAU mRNA] CTD PMID:15322501 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Plaur plasminogen activator, urokinase receptor multiple interactions EXP benazepril inhibits the reaction [Streptozocin results in increased expression of PLAUR mRNA] CTD PMID:15322501 NCBI chr 1:80,053,441...80,068,384
Ensembl chr 1:80,050,324...80,068,595 		JBrowse link
G Plg plasminogen increases activity
multiple interactions		 ISO benazepril results in increased activity of PLG protein
FR 173657 inhibits the reaction [benazepril results in increased activity of PLG protein]		 CTD PMID:15339989 NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786 		JBrowse link
G Prcp prolylcarboxypeptidase affects response to substance ISO PRCP gene SNP affects the susceptibility to benazepril CTD PMID:20079160 NCBI chr 1:146,931,487...146,983,891
Ensembl chr 1:146,930,561...146,984,530 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression
decreases phosphorylation		 EXP benazepril inhibits the reaction [Doxorubicin results in increased expression of RELA mRNA]; benazepril inhibits the reaction [Streptozocin results in increased expression of RELA mRNA]
benazepril results in decreased expression of RELA mRNA; benazepril results in decreased expression of RELA protein
benazepril results in decreased phosphorylation of RELA protein		 CTD PMID:15157388 PMID:17900838 PMID:19018797 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ren renin increases expression
increases activity
multiple interactions		 ISO
EXP		 benazepril results in increased expression of REN protein
benazepril results in increased activity of REN protein
[benazepril co-treated with Valsartan] results in increased activity of REN protein		 CTD PMID:1316404 PMID:10836730 PMID:11501062 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 decreases expression EXP benazepril results in decreased expression of RSAD2 mRNA CTD PMID:14871019 NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699 		JBrowse link
G Serpine1 serpin family E member 1 decreases expression
multiple interactions		 ISO
EXP		 benazepril results in decreased expression of SERPINE1 mRNA; benazepril results in decreased expression of SERPINE1 protein
FR 173657 inhibits the reaction [benazepril results in decreased expression of SERPINE1 mRNA]
benazepril inhibits the reaction [Streptozocin results in increased expression of SERPINE1 mRNA]		 CTD PMID:15322501 PMID:15339989 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Serpinh1 serpin family H member 1 increases expression EXP benazepril results in increased expression of SERPINH1 mRNA CTD PMID:14871019 NCBI chr 1:153,643,500...153,650,853
Ensembl chr 1:153,643,510...153,650,801 		JBrowse link
G Slc15a1 solute carrier family 15 member 1 multiple interactions ISO benazepril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545 		JBrowse link
G Slc15a2 solute carrier family 15 member 2 multiple interactions ISO
EXP		 benazepril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225 		JBrowse link
G Smad2 SMAD family member 2 affects expression
multiple interactions		 EXP benazepril affects the expression of SMAD2 mRNA; benazepril affects the expression of SMAD2 protein
[benazepril co-treated with irbesartan] affects the expression of SMAD2 mRNA; [benazepril co-treated with irbesartan] affects the expression of SMAD2 protein		 CTD PMID:16635409 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Smad3 SMAD family member 3 affects expression
multiple interactions		 EXP benazepril affects the expression of SMAD3 mRNA; benazepril affects the expression of SMAD3 protein
[benazepril co-treated with candesartan] results in decreased expression of SMAD3 protein; [benazepril co-treated with irbesartan] affects the expression of SMAD3 mRNA; [benazepril co-treated with irbesartan] affects the expression of SMAD3 protein		 CTD PMID:16635409 PMID:19487956 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Snrpn small nuclear ribonucleoprotein polypeptide N decreases expression EXP benazepril results in decreased expression of SNRPN mRNA CTD PMID:14871019 NCBI chr 1:111,101,327...111,123,400
Ensembl chr 1:111,101,329...111,123,634 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO [benazepril co-treated with Valsartan] results in increased expression of SOD1 protein CTD PMID:20445533 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression EXP benazepril results in decreased expression of SPP1 mRNA CTD PMID:11867951 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 affects expression
decreases expression
multiple interactions		 EXP
ISO		 benazepril affects the expression of TGFB1 mRNA
benazepril results in decreased expression of TGFB1 mRNA; benazepril results in decreased expression of TGFB1 protein
[benazepril co-treated with Valsartan] results in decreased expression of TGFB1 protein
[benazepril co-treated with candesartan] results in decreased expression of TGFB1 protein; [benazepril co-treated with Irbesartan] affects the expression of TGFB1 mRNA; benazepril inhibits the reaction [Doxorubicin results in increased expression of TGFB1 mRNA]; benazepril inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; benazepril inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; benazepril inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]		 CTD PMID:10515446 PMID:11798627 PMID:11867951 PMID:16191423 PMID:16409969 More... NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 multiple interactions EXP benazepril inhibits the reaction [Streptozocin results in increased expression of TGFBR1 mRNA]; benazepril inhibits the reaction [Streptozocin results in increased expression of TGFBR1 protein] CTD PMID:11798618 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 decreases expression
multiple interactions		 EXP benazepril results in decreased expression of TIMP1 mRNA; benazepril results in decreased expression of TIMP1 protein
benazepril inhibits the reaction [Doxorubicin results in increased expression of TIMP1 mRNA]; benazepril inhibits the reaction [Doxorubicin results in increased expression of TIMP1 protein]		 CTD PMID:11867951 PMID:18471418 PMID:19357873 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions EXP benazepril inhibits the reaction [Streptozocin results in increased expression of TIMP2 mRNA]; benazepril inhibits the reaction [Streptozocin results in increased expression of TIMP2 protein] CTD PMID:16732983 PMID:20821936 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
G Tlr4 toll-like receptor 4 decreases expression ISO benazepril results in decreased expression of TLR4 protein CTD PMID:20981132 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions		 ISO
EXP		 benazepril results in decreased expression of TNF protein
[benazepril co-treated with Amlodipine] results in decreased expression of TNF protein		 CTD PMID:16775501 PMID:20981132 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression EXP benazepril results in decreased expression of VCAM1 mRNA; benazepril results in decreased expression of VCAM1 protein CTD PMID:19018797 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP benazepril inhibits the reaction [Streptozocin results in increased expression of VEGFA protein] CTD PMID:20844835 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
bixin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases ubiquitination ISO bixin results in decreased ubiquitination of NFE2L2 protein CTD PMID:30698894 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
cilazapril monohydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme affects response to substance ISO ACE gene polymorphism affects the susceptibility to Cilazapril CTD PMID:15498266 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO Cilazapril results in increased expression of ADIPOQ protein CTD PMID:19789415 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP [Cilazapril co-treated with Losartan] promotes the reaction [Doxorubicin results in increased expression of AGTR1 mRNA]; Cilazapril promotes the reaction [Doxorubicin results in increased expression of AGTR1 mRNA] CTD PMID:15331931 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions EXP [Losartan co-treated with Cilazapril] inhibits the reaction [Doxorubicin results in decreased expression of AGTR2 mRNA]; Cilazapril inhibits the reaction [Doxorubicin results in decreased expression of AGTR2 mRNA] CTD PMID:15331931 NCBI chr  X:112,119,673...112,124,060
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression EXP Cilazapril results in decreased expression of FGF2 mRNA; Cilazapril results in decreased expression of FGF2 protein CTD PMID:9640960 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Nppa natriuretic peptide A multiple interactions
affects secretion		 ISO [Cilazapril co-treated with Verapamil] affects the secretion of NPPA protein
Cilazapril affects the secretion of NPPA protein		 CTD PMID:1457087 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Ren renin increases activity EXP Cilazapril results in increased activity of REN protein CTD PMID:2425185 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Slc15a1 solute carrier family 15 member 1 multiple interactions ISO Cilazapril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545 		JBrowse link
G Slc15a2 solute carrier family 15 member 2 multiple interactions EXP Cilazapril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [Losartan co-treated with Cilazapril] inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; Cilazapril inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein] CTD PMID:15331931 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
crocin-1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO crocin promotes the reaction [pyrazolanthrone inhibits the reaction [TNFSF11 protein results in increased activity of ACP5 protein]] CTD PMID:30580027 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions ISO crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of AKT2 mRNA] CTD PMID:30580027 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Bambi BMP and activin membrane-bound inhibitor multiple interactions EXP crocin inhibits the reaction [Cisplatin results in decreased expression of BAMBI mRNA] CTD PMID:32259551 NCBI chr17:54,121,251...54,125,816
Ensembl chr17:54,121,255...54,126,060 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 EXP
ISO		 crocin inhibits the reaction [Arsenic Trioxide results in increased expression of BAX mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]; crocin inhibits the reaction [Diazinon results in increased expression of BAX mRNA]; crocin inhibits the reaction [Diazinon results in increased expression of BAX protein]
crocin results in increased expression of BAX mRNA		 CTD PMID:23523949 PMID:27353299 PMID:32886819 PMID:32920515 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 EXP
ISO		 crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]
crocin results in decreased expression of BCL2 mRNA
[crocin co-treated with Paraquat] results in decreased expression of BCL2 mRNA		 CTD PMID:31911963 PMID:32886819 PMID:32920515 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP crocin results in increased expression of BDNF mRNA; crocin results in increased expression of BDNF protein CTD PMID:24401376 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO crocin results in decreased expression of BIRC5 mRNA CTD PMID:32886819 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity
increases cleavage		 EXP
ISO		 crocin affects the reaction [Ethanol results in increased expression of CASP3 mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein]; crocin inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP3 protein]; crocin inhibits the reaction [Diazinon results in increased activity of CASP3 protein]; crocin inhibits the reaction [Diazinon results in increased cleavage of CASP3 protein]; crocin inhibits the reaction [Diazinon results in increased expression of CASP3 protein modified form]; crocin inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; crocin inhibits the reaction [Ethanol results in increased activity of CASP3 protein]
crocin results in increased expression of CASP3 mRNA
crocin results in increased activity of CASP3 protein
crocin inhibits the reaction [Paraquat results in increased expression of CASP3 mRNA]
Acetylcysteine inhibits the reaction [crocin results in increased activity of CASP3 protein]; MIR34A mRNA inhibits the reaction [crocin results in increased activity of CASP3 protein]; MYCN protein inhibits the reaction [crocin results in increased cleavage of CASP3 protein]; PTPN4 protein affects the reaction [crocin results in increased activity of CASP3 protein]		 CTD PMID:23523949 PMID:25637687 PMID:25899501 PMID:26807765 PMID:27353299 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases activity ISO crocin results in increased activity of CASP8 protein CTD PMID:32886819 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity		 EXP
ISO		 crocin inhibits the reaction [Diazinon results in increased cleavage of CASP9 protein]
crocin results in increased activity of CASP9 protein		 CTD PMID:27353299 PMID:32886819 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions
decreases activity
increases activity		 EXP
ISO		 crocin inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]; crocin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; crocin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]
crocin results in decreased activity of CAT protein
crocin inhibits the reaction [Patulin results in increased activity of CAT protein]
crocin results in increased activity of CAT protein		 CTD PMID:25899501 PMID:26584762 PMID:29409856 PMID:32886819 PMID:32920515 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO crocin results in decreased expression of CCND1 mRNA CTD PMID:32886819 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ckm creatine kinase, M-type multiple interactions EXP crocin inhibits the reaction [Diazinon results in increased activity of CKM protein] CTD PMID:23523949 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720 		JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Amino Acids]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of phenylpyruvic acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Allantoin]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Amino Acids]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Carnitine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Citric Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatinine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of phenylacetylglycine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uric Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uridine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased secretion of IL1B protein] CTD PMID:24709313 NCBI chr 7:129,098,489...129,127,620
Ensembl chr 7:129,098,786...129,127,546 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP crocin results in increased expression of and results in increased phosphorylation of CREB1 protein CTD PMID:24401376 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP crocin inhibits the reaction [Diazinon affects the localization of CYCS protein] CTD PMID:23523949 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity
multiple interactions		 EXP crocin results in decreased activity of CYP2E1 protein
crocin inhibits the reaction [Carbon Tetrachloride results in increased activity of CYP2E1 protein]		 CTD PMID:25899501 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Glo1 glyoxalase 1 multiple interactions ISO crocin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of GLO1 protein] CTD PMID:30580027 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP crocin inhibits the reaction [Cisplatin results in increased activity of GPT protein] CTD PMID:32259551 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of HMOX1 protein] CTD PMID:32920515 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like multiple interactions EXP crocin inhibits the reaction [Ethanol results in increased expression of HSPA1L mRNA] CTD PMID:25637687 NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP crocin inhibits the reaction [Doxorubicin results in decreased expression of IL10 protein] CTD PMID:26807765 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased secretion of IL1B protein]; crocin inhibits the reaction [Doxorubicin results in increased expression of IL1B protein] CTD PMID:24709313 PMID:26807765 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression		 EXP
ISO		 crocin inhibits the reaction [Arsenic Trioxide results in increased expression of IL6 mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of IL6 protein]; crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]; crocin inhibits the reaction [Ethanol results in decreased expression of IL6 protein]; crocin inhibits the reaction [Streptozocin results in increased expression of IL6 protein]
crocin results in decreased expression of IL6 mRNA		 CTD PMID:25637687 PMID:25899501 PMID:29409856 PMID:32886819 PMID:32920515 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO crocin affects the expression of and affects the phosphorylation of JAK2 protein CTD PMID:32886819 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions EXP crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of KEAP1 protein] CTD PMID:32920515 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions EXP crocin inhibits the reaction [Diazinon results in decreased expression of LDLR mRNA] CTD PMID:24132704 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation		 EXP
ISO		 crocin inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; crocin inhibits the reaction [Diazinon results in decreased phosphorylation of MAPK1 protein]
crocin results in decreased phosphorylation of MAPK1 protein		 CTD PMID:24132704 PMID:28689058 PMID:32886819 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation		 EXP
ISO		 crocin inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK3 protein]; crocin inhibits the reaction [Diazinon results in decreased phosphorylation of MAPK3 protein]
crocin results in decreased phosphorylation of MAPK3 protein
crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of MAPK3 mRNA]		 CTD PMID:24132704 PMID:28689058 PMID:30580027 PMID:32886819 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mir122 microRNA 122 multiple interactions EXP crocin inhibits the reaction [bisphenol A results in increased expression of MIR122 mRNA] CTD PMID:28689058 NCBI chr18:58,758,703...58,758,787 JBrowse link
G Mir29b1 microRNA 29b-1 increases expression
multiple interactions		 EXP crocin results in increased expression of MIR29B1 mRNA
Cisplatin inhibits the reaction [crocin results in increased expression of MIR29B1 mRNA]; crocin inhibits the reaction [Cisplatin results in decreased expression of MIR29B1 mRNA]		 CTD PMID:32259551 NCBI chr 4:59,650,987...59,651,067
Ensembl chr 4:59,650,986...59,651,067 		JBrowse link
G Mir34a microRNA 34a multiple interactions ISO MIR34A mRNA inhibits the reaction [crocin results in increased activity of CASP3 protein]; MIR34A mRNA inhibits the reaction [crocin results in increased expression of PTPN4 protein] CTD PMID:35085590 NCBI chr 5:160,533,002...160,533,103
Ensembl chr 5:160,533,002...160,533,103 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP crocin inhibits the reaction [Ethanol results in increased activity of MPO protein] CTD PMID:25637687 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO crocin results in decreased expression of MYC mRNA CTD PMID:32886819 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Mycn MYCN proto-oncogene, bHLH transcription factor decreases response to substance
decreases expression
multiple interactions		 ISO MYCN results in decreased susceptibility to crocin
crocin results in decreased expression of MYCN protein
crocin results in decreased expression of and results in decreased stability of MYCN mRNA; MYCN protein inhibits the reaction [crocin results in increased cleavage of CASP3 protein]; MYCN protein inhibits the reaction [crocin results in increased cleavage of PARP1 protein]		 CTD PMID:30672053 NCBI chr 6:35,717,764...35,723,590
Ensembl chr 6:35,717,764...35,723,590 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions EXP crocin inhibits the reaction [Cisplatin results in increased expression of MYD88 mRNA]; crocin inhibits the reaction [Cisplatin results in increased expression of MYD88 protein] CTD PMID:32259551 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of NFE2L2 protein]; crocin inhibits the reaction [Cisplatin results in decreased expression of NFE2L2 protein] CTD PMID:32259551 PMID:32920515 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of NQO1 protein] CTD PMID:32920515 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Ostm1 osteoclastogenesis associated transmembrane protein 1 multiple interactions ISO [crocin co-treated with pyrazolanthrone co-treated with TNFSF11 protein] results in decreased expression of OSTM1 mRNA; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of OSTM1 mRNA] CTD PMID:30580027 NCBI chr20:46,071,657...46,187,049
Ensembl chr20:46,153,075...46,187,023 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions		 ISO crocin results in increased cleavage of PARP1 protein
MYCN protein inhibits the reaction [crocin results in increased cleavage of PARP1 protein]		 CTD PMID:30672053 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO crocin results in decreased expression of PTGS2 mRNA CTD PMID:32886819 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptpn4 protein tyrosine phosphatase, non-receptor type 4 multiple interactions
increases expression		 ISO MIR34A mRNA inhibits the reaction [crocin results in increased expression of PTPN4 protein]; PTPN4 protein affects the reaction [crocin results in increased activity of CASP3 protein] CTD PMID:35085590 NCBI chr13:30,772,012...30,952,340
Ensembl chr13:30,776,682...30,952,170 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP crocin inhibits the reaction [Arsenic Trioxide results in increased expression of RELA protein]; crocin inhibits the reaction [Streptozocin results in increased expression of RELA protein] CTD PMID:29409856 PMID:32920515 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Smad2 SMAD family member 2 decreases expression
multiple interactions		 EXP crocin results in decreased expression of SMAD2 protein
Cisplatin inhibits the reaction [crocin results in decreased expression of SMAD2 protein]; crocin inhibits the reaction [Cisplatin results in increased expression of SMAD2 protein]		 CTD PMID:32259551 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO crocin affects the expression of and affects the phosphorylation of STAT3 protein CTD PMID:32886819 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP crocin inhibits the reaction [Cisplatin results in increased expression of TGFB1 protein]; crocin inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein] CTD PMID:29409856 PMID:32259551 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 multiple interactions EXP crocin inhibits the reaction [Cisplatin results in increased expression of TGFBR1 protein] CTD PMID:32259551 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP crocin inhibits the reaction [Cisplatin results in increased expression of TLR4 mRNA]; crocin inhibits the reaction [Cisplatin results in increased expression of TLR4 protein]; crocin inhibits the reaction [Streptozocin results in increased expression of TLR4 protein] CTD PMID:29409856 PMID:32259551 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 EXP
ISO		 crocin inhibits the reaction [Arsenic Trioxide results in increased expression of TNF mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of TNF protein]; crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; crocin inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; crocin inhibits the reaction [Ethanol results in decreased expression of TNF protein]
crocin results in decreased expression of TNF mRNA		 CTD PMID:25637687 PMID:25899501 PMID:26807765 PMID:32886819 PMID:32920515 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO [crocin co-treated with pyrazolanthrone co-treated with TNFSF11 protein] results in decreased expression of OSTM1 mRNA; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of AKT2 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of MAPK3 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of OSTM1 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of TRAF6 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of GLO1 protein]; crocin promotes the reaction [pyrazolanthrone inhibits the reaction [TNFSF11 protein results in increased activity of ACP5 protein]] CTD PMID:30580027 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Tnnt2 troponin T2, cardiac type multiple interactions EXP crocin inhibits the reaction [Doxorubicin results in increased expression of TNNT2 protein] CTD PMID:26807765 NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO crocin inhibits the reaction [Paraquat results in increased expression of TRP53 mRNA] CTD PMID:31911963 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of TRAF6 mRNA] CTD PMID:30580027 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Vgf VGF nerve growth factor inducible increases expression EXP crocin results in increased expression of VGF protein CTD PMID:24401376 NCBI chr12:19,637,313...19,645,123
Ensembl chr12:19,637,320...19,640,341 		JBrowse link
enalapril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 increases transport ISO ABCC4 protein results in increased transport of Enalapril CTD PMID:17939016 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Ace angiotensin I converting enzyme decreases activity
multiple interactions
increases expression		 ISO
EXP		 Enalapril results in decreased activity of ACE protein
Enalapril inhibits the reaction [Dexamethasone results in increased expression of ACE protein]; Enalapril inhibits the reaction [diisononyl phthalate promotes the reaction [Dexamethasone results in increased expression of ACE protein]]
ACE gene polymorphism affects the susceptibility to [Enalapril co-treated with Sodium Chloride]; ACE gene polymorphism inhibits the reaction [[Enalapril co-treated with Sodium Chloride] results in increased susceptibility to AGT protein modified form]
Enalapril results in increased expression of ACE mRNA
Enalapril inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of ACE protein]; Enalapril promotes the reaction [Folic Acid results in increased expression of ACE mRNA]		 CTD PMID:15728788 PMID:15816410 PMID:20679179 PMID:20829712 PMID:23733546 More... NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression EXP Enalapril results in decreased expression of ACTA2 protein CTD PMID:19349682 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Acvrl1 activin A receptor like type 1 decreases expression EXP Enalapril results in decreased expression of ACVRL1 protein CTD PMID:12883979 NCBI chr 7:132,239,200...132,256,592
Ensembl chr 7:132,239,729...132,256,591 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO Enalapril results in increased expression of ADIPOQ protein CTD PMID:25037058 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Adrb1 adrenoceptor beta 1 increases expression EXP Enalapril results in increased expression of ADRB1 protein CTD PMID:7586371 NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Agt angiotensinogen decreases activity
affects response to substance
increases expression
decreases response to substance
multiple interactions
decreases expression		 EXP
ISO		 Enalapril results in decreased activity of AGT protein modified form
AGT gene alternative form affects the susceptibility to Enalapril; AGT protein polymorphism affects the susceptibility to Enalapril
Enalapril results in increased expression of AGT mRNA
Enalapril results in decreased susceptibility to AGT protein modified form
Enalapril affects the reaction [chymostatin results in decreased susceptibility to AGT protein modified form]; Enalapril inhibits the reaction [Cyclosporine results in increased expression of AGT protein]; Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased expression of AGT protein]
Enalapril results in decreased expression of AGT protein modified form
[Enalapril co-treated with Sodium Chloride] results in increased susceptibility to AGT protein modified form; ACE gene polymorphism inhibits the reaction [[Enalapril co-treated with Sodium Chloride] results in increased susceptibility to AGT protein modified form]; Enalapril inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]
Enalapril results in decreased expression of AGT mRNA		 CTD PMID:1330361 PMID:2474097 PMID:6319675 PMID:12003776 PMID:12911327 More... NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a affects expression
multiple interactions
decreases expression
increases expression		 EXP
ISO		 Enalapril affects the expression of AGTR1A mRNA
Enalapril inhibits the reaction [Dexamethasone results in increased expression of AGTR1 protein]; Enalapril inhibits the reaction [diisononyl phthalate promotes the reaction [Dexamethasone results in increased expression of AGTR1 protein]]
Enalapril results in decreased expression of AGTR1A mRNA
Enalapril inhibits the reaction [Cyclosporine results in decreased expression of AGTR1A mRNA]
Enalapril results in increased expression of AGTR1A mRNA		 CTD PMID:14659064 PMID:18403896 PMID:18765277 PMID:18796534 PMID:30940551 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 increases expression
decreases expression		 EXP Enalapril results in increased expression of AGTR2 mRNA
Enalapril results in decreased expression of AGTR2 mRNA		 CTD PMID:9740612 PMID:18403896 PMID:18765277 NCBI chr  X:112,119,673...112,124,060
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Enalapril promotes the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein] CTD PMID:18806606 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions EXP Enalapril inhibits the reaction [Corticosterone results in decreased expression of ALPL mRNA]; Enalapril inhibits the reaction [Ethanol results in decreased expression of ALPL mRNA] CTD PMID:30423288 PMID:31887396 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Ang angiogenin decreases expression ISO Enalapril results in decreased expression of ANG protein CTD PMID:3038326 NCBI chr15:24,317,733...24,323,361 JBrowse link
G Angpt2 angiopoietin 2 multiple interactions EXP Enalapril inhibits the reaction [Streptozocin results in increased expression of ANGPT2 mRNA] CTD PMID:19958114 NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804 		JBrowse link
G Apoe apolipoprotein E multiple interactions ISO [Bezafibrate co-treated with Enalapril co-treated with Dipyridamole co-treated with Atorvastatin co-treated with Valsartan] results in decreased expression of APOE protein
Enalapril inhibits the reaction [APOE gene mutant form results in decreased abundance of Antioxidants]; Enalapril inhibits the reaction [APOE gene mutant form results in increased abundance of Cholesterol]		 CTD PMID:19603250 PMID:25037058 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Atf2 activating transcription factor 2 increases expression EXP Enalapril results in increased expression of ATF2 protein CTD PMID:15531746 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236 		JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 increases expression EXP Enalapril results in increased expression of ATP1A2 mRNA; Enalapril results in increased expression of ATP1A2 protein CTD PMID:18418421 NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544 		JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 decreases expression EXP Enalapril results in decreased expression of ATP1A3 mRNA; Enalapril results in decreased expression of ATP1A3 protein CTD PMID:18418421 NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918 		JBrowse link
G Avp arginine vasopressin multiple interactions EXP Enalapril promotes the reaction [Dexamethasone results in increased activity of AVP protein] CTD PMID:3346065 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression EXP Enalapril results in decreased expression of BAX protein CTD PMID:21153712 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions		 EXP Enalapril results in increased expression of BCL2 protein
Enalapril inhibits the reaction [Isoproterenol results in decreased expression of BCL2 protein]		 CTD PMID:21153712 PMID:30623541 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bdkrb1 bradykinin receptor B1 increases expression
multiple interactions		 EXP Enalapril results in increased expression of BDKRB1 mRNA
[kallidin, des-Arg(10)- results in decreased activity of BDKRB1 protein] which results in decreased susceptibility to Enalapril		 CTD PMID:18796534 PMID:21430409 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747 		JBrowse link
G Bdkrb2 bradykinin receptor B2 increases expression EXP Enalapril results in increased expression of BDKRB2 mRNA; Enalapril results in increased expression of BDKRB2 protein CTD PMID:18190998 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions EXP Enalapril inhibits the reaction [Corticosterone results in decreased expression of BGLAP mRNA]; Enalapril inhibits the reaction [Ethanol results in decreased expression of BGLAP mRNA] CTD PMID:30423288 PMID:31887396 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495 		JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Enalapril results in decreased activity of CA2 protein CTD PMID:28126276 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Casp3 caspase 3 decreases activity
multiple interactions		 EXP Enalapril results in decreased activity of CASP3 protein
Enalapril inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]		 CTD PMID:21153712 PMID:30623541 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 decreases activity EXP Enalapril results in decreased activity of CASP9 protein CTD PMID:21153712 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase increases activity
multiple interactions		 EXP Enalapril results in increased activity of CAT protein
Enalapril inhibits the reaction [Isoproterenol results in decreased expression of CAT protein]		 CTD PMID:12124199 PMID:30623541 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
multiple interactions		 ISO
EXP		 Enalapril results in decreased expression of CCL2 protein
[paricalcitol co-treated with Enalapril] results in decreased expression of CCL2 protein
Enalapril inhibits the reaction [sodium arsenite results in increased secretion of CCL2 protein]
Enalapril results in decreased expression of CCL2 mRNA		 CTD PMID:10925121 PMID:17513326 PMID:19627010 PMID:20720404 PMID:25037058 More... NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression
multiple interactions		 EXP
ISO		 Enalapril results in decreased expression of CCN2 mRNA; Enalapril results in decreased expression of CCN2 protein
Enalapril inhibits the reaction [Streptozocin results in increased expression of CCN2 protein]		 CTD PMID:18812665 PMID:19349682 PMID:21416479 PMID:25037058 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Cela2a chymotrypsin like elastase 2A decreases expression EXP Enalapril results in decreased expression of CELA2A mRNA CTD PMID:21602471 NCBI chr 5:154,126,879...154,136,630
Ensembl chr 5:154,126,878...154,136,632 		JBrowse link
G Cltrn collectrin, amino acid transport regulator decreases expression EXP Enalapril results in decreased expression of CLTRN mRNA; Enalapril results in decreased expression of CLTRN protein CTD PMID:12887829 NCBI chr  X:30,361,967...30,395,264
Ensembl chr  X:30,361,967...30,395,349 		JBrowse link
G Clu clusterin decreases expression EXP Enalapril results in decreased expression of CLU protein CTD PMID:12193663 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Cma1 chymase 1 decreases expression EXP Enalapril results in decreased expression of CMA1 mRNA CTD PMID:18796534 NCBI chr15:29,417,451...29,420,233
Ensembl chr15:29,417,451...29,420,233 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Enalapril inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA] CTD PMID:12003776 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression
decreases expression		 ISO
EXP		 Enalapril results in increased expression of COL3A1 mRNA
Enalapril results in decreased expression of COL3A1 mRNA		 CTD PMID:17164399 PMID:25037058 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Col4a1 collagen type IV alpha 1 chain multiple interactions
decreases expression		 EXP [eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]; [eplerenone co-treated with Enalapril] results in decreased expression of COL4A1 mRNA; [eplerenone co-treated with Enalapril] results in decreased expression of COL4A1 protein; Enalapril inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]; Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of COL4A1 mRNA]
Enalapril results in decreased expression of COL4A1 mRNA; Enalapril results in decreased expression of COL4A1 protein		 CTD PMID:9175058 PMID:18682491 NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412 		JBrowse link
G Cyba cytochrome b-245 alpha chain decreases expression
multiple interactions		 ISO Enalapril results in decreased expression of CYBA protein
[paricalcitol co-treated with Enalapril] results in decreased expression of CYBA protein		 CTD PMID:20720404 PMID:25037058 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Cycs cytochrome c, somatic affects localization EXP Enalapril affects the localization of CYCS protein CTD PMID:21153712 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO Enalapril inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] CTD PMID:19299527 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Edn1 endothelin 1 multiple interactions EXP Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA] CTD PMID:9175058 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Eng endoglin multiple interactions ISO [Enalapril co-treated with paricalcitol] results in decreased expression of ENG mRNA CTD PMID:25037058 NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230 		JBrowse link
G Epo erythropoietin decreases expression
multiple interactions		 ISO
EXP		 Enalapril results in decreased expression of EPO protein
Enalapril inhibits the reaction [Streptozocin results in increased expression of EPO mRNA]		 CTD PMID:2474097 PMID:9434678 PMID:19958114 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Epor erythropoietin receptor multiple interactions EXP Enalapril inhibits the reaction [Streptozocin results in increased expression of EPOR mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of EPOR protein] CTD PMID:19958114 NCBI chr 8:20,489,678...20,494,257
Ensembl chr 8:20,489,678...20,494,257 		JBrowse link
G F3 coagulation factor III, tissue factor decreases expression
multiple interactions		 ISO Enalapril results in decreased expression of F3 protein
Enalapril inhibits the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]		 CTD PMID:18060435 PMID:22188725 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Faslg Fas ligand decreases expression EXP Enalapril results in decreased expression of FASLG mRNA CTD PMID:10925121 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Gh1 growth hormone 1 increases response to substance ISO GH1 protein results in increased susceptibility to Enalapril CTD PMID:12883983 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078 		JBrowse link
G Gja5 gap junction protein, alpha 5 multiple interactions ISO GJA5 affects the reaction [Enalapril results in increased secretion of REN protein] CTD PMID:19109587 NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952 		JBrowse link
G Gjc1 gap junction protein, gamma 1 multiple interactions ISO GJC1 affects the reaction [Enalapril results in increased secretion of REN protein] CTD PMID:19109587 NCBI chr10:87,758,192...87,785,443
Ensembl chr10:87,760,528...87,785,867 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP Enalapril inhibits the reaction [Isoproterenol results in decreased phosphorylation of GSK3B protein] CTD PMID:18806606 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Has2 hyaluronan synthase 2 increases expression EXP Enalapril results in increased expression of HAS2 mRNA CTD PMID:20933085 NCBI chr 7:88,113,326...88,139,337
Ensembl chr 7:88,113,326...88,128,933 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP
ISO		 Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased expression of HMGB1 protein]
Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of HMGB1 protein]		 CTD PMID:19114890 NCBI chr12:5,973,062...5,978,565
Ensembl chr12:5,901,586...5,978,565 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Enalapril results in increased expression of HMOX1 protein CTD PMID:21263376 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hyal1 hyaluronidase 1 decreases expression EXP Enalapril results in decreased expression of HYAL1 mRNA; Enalapril results in decreased expression of HYAL1 protein CTD PMID:20933085 NCBI chr 8:108,250,654...108,254,526
Ensembl chr 8:108,250,667...108,260,210 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
multiple interactions		 EXP
ISO		 Enalapril results in decreased expression of ICAM1 protein
[Enalapril co-treated with paricalcitol] results in decreased expression of ICAM1 mRNA
Enalapril results in decreased expression of ICAM1 protein modified form
Enalapril inhibits the reaction [sodium arsenite results in increased secretion of ICAM1 protein modified form]		 CTD PMID:14716214 PMID:17347482 PMID:25037058 PMID:28973481 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Igf1 insulin-like growth factor 1 affects expression
decreases expression		 EXP Enalapril affects the expression of IGF1 protein
Enalapril results in decreased expression of IGF1 mRNA		 CTD PMID:12883983 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression EXP Enalapril results in increased expression of IGFBP1 mRNA CTD PMID:12883983 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Enalapril inhibits the reaction [IL1A protein results in increased expression of VEGFA mRNA]; Enalapril inhibits the reaction [IL1A protein results in increased expression of VEGFA protein] CTD PMID:17299153 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression		 EXP
ISO		 Enalapril inhibits the reaction [Acrolein results in increased expression of IL1B mRNA]; Enalapril inhibits the reaction [Acrolein results in increased expression of IL1B protein]; Enalapril inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA]
Enalapril results in decreased expression of IL1B mRNA		 CTD PMID:17167242 PMID:21265103 PMID:25037058 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
affects response to substance		 EXP
ISO		 Enalapril inhibits the reaction [Acrolein results in increased expression of IL6 mRNA]; Enalapril inhibits the reaction [Acrolein results in increased expression of IL6 protein]; Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased expression of IL6 protein]; Enalapril inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]; Enalapril inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]
Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of IL6 protein]
IL6 gene polymorphism affects the susceptibility to Enalapril		 CTD PMID:15342284 PMID:17167242 PMID:19114890 PMID:21265103 PMID:30623541 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO [Atorvastatin co-treated with Enalapril] results in decreased expression of IRAK1 mRNA CTD PMID:20524934 NCBI chr  X:151,768,621...151,778,521
Ensembl chr  X:151,768,777...151,778,521 		JBrowse link
G Itga2 integrin subunit alpha 2 decreases expression ISO Enalapril results in decreased expression of ITGA2 mRNA CTD PMID:25037058 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481 		JBrowse link
G Kdr kinase insert domain receptor multiple interactions EXP Enalapril inhibits the reaction [Cyclosporine results in increased expression of KDR mRNA] CTD PMID:12110003 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Kng2 kininogen 2 increases response to substance EXP Enalapril results in increased susceptibility to KNG1 protein modified form CTD PMID:18190998 NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971 		JBrowse link
G Lamb1 laminin subunit beta 1 multiple interactions EXP Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB1 mRNA] CTD PMID:9175058 NCBI chr 6:47,835,492...47,902,585
Ensembl chr 6:47,835,525...47,902,585 		JBrowse link
G Lamb2 laminin subunit beta 2 multiple interactions EXP Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB2 mRNA] CTD PMID:9175058 NCBI chr 8:109,178,367...109,190,552
Ensembl chr 8:109,178,409...109,190,549 		JBrowse link
G Lep leptin increases response to substance ISO LEP protein results in increased susceptibility to Enalapril CTD PMID:20614101 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases expression
increases phosphorylation		 EXP Enalapril results in increased expression of MAPK9 mRNA; Enalapril results in increased expression of MAPK9 protein
Enalapril results in increased phosphorylation of MAPK9 protein		 CTD PMID:15531746 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mir146a microRNA 146a multiple interactions ISO [Atorvastatin co-treated with Enalapril] results in decreased expression of MIR146A CTD PMID:20524934 NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610 		JBrowse link
G Mir146b microRNA 146b multiple interactions ISO [Atorvastatin co-treated with Enalapril] results in decreased expression of MIR146B CTD PMID:20524934 NCBI chr 1:245,203,438...245,203,525
Ensembl chr 1:245,203,438...245,203,525 		JBrowse link
G Mmp3 matrix metallopeptidase 3 decreases expression ISO Enalapril results in decreased expression of MMP3 mRNA CTD PMID:25037058 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased activity of MPO protein] CTD PMID:19114890 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Myh6 myosin heavy chain 6 multiple interactions EXP Enalapril inhibits the reaction [Streptozocin results in decreased expression of MYH6 mRNA]; Enalapril inhibits the reaction [Streptozocin results in decreased expression of MYH6 protein] CTD PMID:15362513 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720 		JBrowse link
G Myh7 myosin heavy chain 7 decreases expression
multiple interactions		 EXP Enalapril results in decreased expression of MYH7 mRNA
Enalapril inhibits the reaction [Streptozocin results in increased expression of MYH7 mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of MYH7 protein]		 CTD PMID:15362513 PMID:21423293 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217 		JBrowse link
G Ndst1 N-deacetylase and N-sulfotransferase 1 multiple interactions EXP Enalapril inhibits the reaction [Streptozocin results in decreased expression of NDST1 protein] CTD PMID:15793251 NCBI chr18:54,136,887...54,199,545
Ensembl chr18:54,140,779...54,178,191 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases expression EXP Enalapril results in decreased expression of NFE2L2 mRNA CTD PMID:18765277 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases activity
multiple interactions		 EXP Enalapril results in decreased activity of NFKB1 protein
Enalapril inhibits the reaction [Acrolein results in increased expression of NFKB1 mRNA]; Enalapril inhibits the reaction [Acrolein results in increased expression of NFKB1 protein]		 CTD PMID:19225048 PMID:21265102 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased degradation of and results in increased phosphorylation of NFKBIA protein] CTD PMID:19114890 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Noa1 nitric oxide associated 1 increases expression
increases activity		 EXP Enalapril results in increased expression of NOA1 mRNA
Enalapril results in increased activity of NOA1 protein		 CTD PMID:14588141 NCBI chr14:30,835,012...30,851,296
Ensembl chr14:30,835,247...30,851,293 		JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions		 ISO
EXP		 Enalapril results in decreased expression of NOS2 protein
[paricalcitol co-treated with Enalapril] results in decreased expression of NOS2 protein		 CTD PMID:20720404 PMID:21377515 PMID:25037058 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
increases expression
affects expression		 EXP
ISO		 [Enalapril co-treated with eplerenone] results in decreased expression of NOS3 mRNA; Enalapril inhibits the reaction [Nitric Oxide deficiency results in decreased expression of NOS3 protein]
[paricalcitol co-treated with Enalapril] results in increased expression of NOS3 protein; Enalapril inhibits the reaction [Dexamethasone results in decreased expression of NOS3 protein]; Enalapril inhibits the reaction [diisononyl phthalate promotes the reaction [Dexamethasone results in decreased expression of NOS3 protein]]
Enalapril results in increased expression of NOS3 protein
Enalapril affects the expression of NOS3 mRNA		 CTD PMID:12176110 PMID:16197366 PMID:20571278 PMID:20720404 PMID:25037058 More... NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nppa natriuretic peptide A decreases expression ISO
EXP		 Enalapril results in decreased expression of NPPA protein
Enalapril results in decreased expression of NPPA mRNA		 CTD PMID:2136812 PMID:8112904 PMID:21423293 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP Enalapril inhibits the reaction [Isoproterenol results in increased expression of NPPB protein] CTD PMID:18806606 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 increases expression EXP Enalapril results in increased expression of NR3C2 mRNA CTD PMID:18796534 NCBI chr19:30,715,648...31,059,885
Ensembl chr19:30,715,648...31,059,885 		JBrowse link
G Nrf1 nuclear respiratory factor 1 increases expression EXP Enalapril results in increased expression of NRF1 mRNA CTD PMID:18765277 NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328 		JBrowse link
G Pdpn podoplanin increases expression EXP Enalapril results in increased expression of PDPN protein CTD PMID:20933085 NCBI chr 5:155,601,691...155,635,656
Ensembl chr 5:155,601,691...155,635,656 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [Enalapril co-treated with Glucose] binds to PPARA protein; Enalapril inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]] CTD PMID:18812576 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression
multiple interactions		 EXP Enalapril results in decreased expression of PPARG protein
Enalapril inhibits the reaction [Isoproterenol results in decreased expression of PPARG protein]		 CTD PMID:19225048 PMID:30623541 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression EXP Enalapril results in increased expression of PPARGC1A mRNA CTD PMID:18765277 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases expression ISO Enalapril results in increased expression of PRKAA1 protein CTD PMID:25037058 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Prkca protein kinase C, alpha decreases expression EXP Enalapril results in decreased expression of PRKCA protein modified form CTD PMID:21565836 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression ISO Enalapril results in decreased expression of PTGS1 mRNA CTD PMID:25037058 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions		 EXP
ISO		 Enalapril results in decreased expression of PTGS2 protein
[paricalcitol co-treated with Enalapril] results in decreased expression of PTGS2 protein		 CTD PMID:20720404 PMID:21377515 PMID:25037058 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pth1r parathyroid hormone 1 receptor multiple interactions EXP Enalapril inhibits the reaction [Folic Acid results in decreased expression of PTH1R protein] CTD PMID:15728788 NCBI chr 8:110,693,910...110,725,458
Ensembl chr 8:110,697,485...110,719,729 		JBrowse link
G Pthlh parathyroid hormone-like hormone multiple interactions EXP Enalapril inhibits the reaction [Folic Acid results in increased expression of PTHLH mRNA]; Enalapril inhibits the reaction [Folic Acid results in increased expression of PTHLH protein] CTD PMID:15728788 NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Enalapril inhibits the reaction [Isoproterenol results in increased expression of RELA protein] CTD PMID:30623541 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ren renin multiple interactions
increases expression
increases secretion
decreases activity
increases activity		 ISO
EXP		 [Indomethacin co-treated with Enalapril] results in decreased expression of REN protein; Enalapril inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]
Enalapril results in increased expression of REN mRNA; Enalapril results in increased expression of REN protein
Enalapril results in increased secretion of REN protein
[Sodium Chloride deficiency co-treated with Enalapril] results in increased expression of REN mRNA; GJA5 affects the reaction [Enalapril results in increased secretion of REN protein]; GJC1 affects the reaction [Enalapril results in increased secretion of REN protein]; REN enhancer mutant form results in decreased susceptibility to [Sodium Chloride deficiency co-treated with Enalapril]; Sodium inhibits the reaction [Enalapril results in increased expression of REN mRNA]; Sodium inhibits the reaction [Enalapril results in increased expression of REN protein]; Sodium inhibits the reaction [Enalapril results in increased secretion of REN protein]
Enalapril results in decreased activity of REN protein
Enalapril results in increased activity of REN protein		 CTD PMID:1330361 PMID:2994932 PMID:6094050 PMID:11078175 PMID:12434137 More... NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions EXP Enalapril inhibits the reaction [Corticosterone results in decreased expression of RUNX2 mRNA]; Enalapril inhibits the reaction [Ethanol results in decreased expression of RUNX2 mRNA] CTD PMID:30423288 PMID:31887396 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Sele selectin E multiple interactions ISO Enalapril inhibits the reaction [sodium arsenite results in increased expression of SELE protein] CTD PMID:28973481 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Sell selectin L multiple interactions ISO [Enalapril co-treated with paricalcitol] results in decreased expression of SELL mRNA CTD PMID:25037058 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456 		JBrowse link
G Selp selectin P multiple interactions
decreases expression		 EXP
ISO		 Enalapril inhibits the reaction [Diclofenac results in decreased expression of SELP protein]
Enalapril results in decreased expression of SELP mRNA		 CTD PMID:14716214 PMID:25037058 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845 		JBrowse link
G Serpinb2 serpin family B member 2 decreases expression ISO Enalapril results in decreased expression of SERPINB2 mRNA CTD PMID:25037058 NCBI chr13:23,537,312...23,551,823
Ensembl chr13:23,541,400...23,550,408 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions
decreases expression		 EXP [eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]; [eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]; [eplerenone co-treated with Enalapril] results in decreased expression of SERPINE1 mRNA; [eplerenone co-treated with Enalapril] results in decreased expression of SERPINE1 protein; Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]; Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]
Enalapril results in decreased expression of SERPINE1 mRNA; Enalapril results in decreased expression of SERPINE1 protein		 CTD PMID:18682491 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Slc15a2 solute carrier family 15 member 2 multiple interactions ISO Enalapril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225 		JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions ISO Enalapril inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid] CTD PMID:21272127 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions ISO Enalapril inhibits the reaction [SLC22A7 protein results in increased uptake of Glutarates] CTD PMID:12065749 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions ISO Enalapril inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:15100168 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Smad2 SMAD family member 2 multiple interactions EXP Enalapril promotes the reaction [paricalcitol results in decreased phosphorylation of SMAD2 protein] CTD PMID:17513326 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Smad7 SMAD family member 7 increases expression EXP Enalapril results in increased expression of SMAD7 mRNA; Enalapril results in increased expression of SMAD7 protein CTD PMID:19197123 PMID:19349682 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression
multiple interactions		 ISO Enalapril results in increased expression of SOD1 protein
[paricalcitol co-treated with Enalapril] results in increased expression of SOD1 protein		 CTD PMID:20720404 PMID:25037058 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 decreases activity
multiple interactions
decreases expression		 EXP
ISO		 Enalapril results in decreased activity of SOD2 protein
[paricalcitol co-treated with Enalapril] results in decreased expression of SOD2 protein
Enalapril results in decreased expression of SOD2 protein		 CTD PMID:18765277 PMID:20720404 PMID:25037058 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO
EXP		 [Enalapril co-treated with paricalcitol] results in decreased expression of SPP1 mRNA
Enalapril inhibits the reaction [Corticosterone results in decreased expression of SPP1 mRNA]; Enalapril inhibits the reaction [Ethanol results in decreased expression of SPP1 mRNA]		 CTD PMID:25037058 PMID:30423288 PMID:31887396 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Ssbp1 single stranded DNA binding protein 1 increases expression EXP Enalapril results in increased expression of SSBP1 mRNA CTD PMID:18765277 NCBI chr 4:69,266,024...69,276,135
Ensembl chr 4:69,266,102...69,276,135 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP Enalapril inhibits the reaction [Streptozocin results in increased expression of STAT3 mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of STAT3 protein] CTD PMID:19958114 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tek TEK receptor tyrosine kinase multiple interactions EXP Enalapril inhibits the reaction [Streptozocin results in increased expression of TEK mRNA] CTD PMID:19958114 NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression		 EXP [eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; [eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]]; [eplerenone co-treated with Enalapril] results in decreased expression of TGFB1 mRNA; [eplerenone co-treated with Enalapril] results in decreased expression of TGFB1 protein; Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; Enalapril inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]]; Enalapril inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]; Enalapril promotes the reaction [paricalcitol results in decreased expression of TGFB1 mRNA]; Enalapril promotes the reaction [paricalcitol results in decreased expression of TGFB1 protein]
Enalapril results in decreased expression of TGFB1 mRNA; Enalapril results in decreased expression of TGFB1 protein		 CTD PMID:12883979 PMID:15309289 PMID:17164399 PMID:17513326 PMID:18682491 More... NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 decreases expression EXP Enalapril results in decreased expression of TGFB2 mRNA CTD PMID:17164399 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Tgfbi transforming growth factor, beta induced decreases secretion
multiple interactions		 EXP Enalapril results in decreased secretion of TGFBI protein
[eplerenone co-treated with Enalapril] results in decreased secretion of TGFBI protein		 CTD PMID:18682491 NCBI chr17:7,955,603...7,984,903
Ensembl chr17:7,955,603...7,985,240 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 decreases expression EXP Enalapril results in decreased expression of TGFBR1 mRNA; Enalapril results in decreased expression of TGFBR1 protein CTD PMID:12883979 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Thbs4 thrombospondin 4 increases expression ISO Enalapril results in increased expression of THBS4 mRNA CTD PMID:25037058 NCBI chr 2:23,983,158...24,025,289
Ensembl chr 2:23,983,158...24,026,313 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO [Atorvastatin co-treated with Enalapril] results in decreased expression of TLR4 mRNA; [Atorvastatin co-treated with Enalapril] results in decreased expression of TLR4 protein CTD PMID:20524934 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions		 EXP
ISO		 Enalapril results in decreased expression of TNF protein
Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased expression of TNF protein]; Enalapril inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; Enalapril inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]
[paricalcitol co-treated with Enalapril] results in decreased expression of TNF protein; Enalapril inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of TNF protein]
Enalapril inhibits the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]; Enalapril inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Enalapril inhibits the reaction [TNF protein results in increased expression of VEGFA protein]		 CTD PMID:12003776 PMID:16336586 PMID:17167242 PMID:17299153 PMID:18060435 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tomm20 translocase of outer mitochondrial membrane 20 decreases expression EXP Enalapril results in decreased expression of TOMM20 mRNA CTD PMID:18765277 NCBI chr19:54,925,197...54,935,188
Ensembl chr19:54,923,402...54,935,198 		JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO [Atorvastatin co-treated with Enalapril] results in decreased expression of TRAF6 mRNA CTD PMID:20524934 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 affects expression
decreases expression		 ISO Enalapril affects the expression of VCAM1
Enalapril results in decreased expression of VCAM1 mRNA; Enalapril results in decreased expression of VCAM1 protein modified form		 CTD PMID:17347482 PMID:19939336 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression		 EXP
ISO		 Enalapril inhibits the reaction [Cyclosporine results in increased expression of VEGFA protein]
Enalapril inhibits the reaction [IL1A protein results in increased expression of VEGFA mRNA]; Enalapril inhibits the reaction [IL1A protein results in increased expression of VEGFA protein]; Enalapril inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Enalapril inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; Enalapril inhibits the reaction [VEGFA protein results in increased expression of VEGFA mRNA]
Enalapril results in increased expression of VEGFA protein		 CTD PMID:12110003 PMID:16202860 PMID:17299153 PMID:21263376 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vwf von Willebrand factor decreases expression ISO Enalapril results in decreased expression of VWF mRNA CTD PMID:25037058 NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539 		JBrowse link
fumagillin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP fumagillin inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 mRNA] CTD PMID:15682466 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Metap1 methionyl aminopeptidase 1 decreases activity
multiple interactions		 ISO fumagillin results in decreased activity of METAP1 protein
[fumagillin results in decreased activity of [METAP1 protein co-treated with METAP2 protein]] which results in decreased metabolism of YWHAG protein		 CTD PMID:14534293 NCBI chr 2:226,991,305...227,024,360
Ensembl chr 2:226,991,301...227,024,434 		JBrowse link
G Metap2 methionyl aminopeptidase 2 multiple interactions
decreases activity		 EXP
ISO		 fumagillin promotes the reaction [Diethylnitrosamine results in increased expression of METAP2 mRNA]
fumagillin results in decreased activity of METAP2 protein
[fumagillin results in decreased activity of [METAP1 protein co-treated with METAP2 protein]] which results in decreased metabolism of YWHAG protein		 CTD PMID:14534293 PMID:15516829 PMID:15682466 NCBI chr 7:28,412,771...28,440,458
Ensembl chr 7:28,411,608...28,440,434 		JBrowse link
G Tert telomerase reverse transcriptase multiple interactions EXP fumagillin inhibits the reaction [Diethylnitrosamine results in increased activity of TERT protein]; fumagillin inhibits the reaction [Diethylnitrosamine results in increased expression of TERT mRNA] CTD PMID:15682466 NCBI chr 1:29,637,213...29,659,509
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma multiple interactions ISO [fumagillin results in decreased activity of [METAP1 protein co-treated with METAP2 protein]] which results in decreased metabolism of YWHAG protein CTD PMID:14534293 NCBI chr12:20,744,500...20,772,828
Ensembl chr12:20,744,535...20,772,827 		JBrowse link
hydrocortisone succinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [hydrocortisone hemisuccinate co-treated with Dimethyl Sulfoxide] results in increased expression of CYP1A2 CTD PMID:18347083 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [hydrocortisone hemisuccinate co-treated with Dimethyl Sulfoxide] results in increased expression of CYP3A4 CTD PMID:18347083 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G F2 coagulation factor II affects expression ISO hydrocortisone hemisuccinate affects the expression of F2 protein CTD PMID:12542493 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G Il18 interleukin 18 decreases secretion ISO hydrocortisone hemisuccinate results in decreased secretion of IL18 protein CTD PMID:20421217 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta decreases secretion ISO hydrocortisone hemisuccinate results in decreased secretion of IL1B protein CTD PMID:20421217 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 decreases secretion ISO hydrocortisone hemisuccinate results in decreased secretion of IL6 protein CTD PMID:20421217 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Tnf tumor necrosis factor decreases secretion ISO hydrocortisone hemisuccinate results in decreased secretion of TNF protein CTD PMID:20421217 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
imidapril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin I converting enzyme 2 increases response to substance ISO ACE2 gene SNP results in increased susceptibility to imidapril CTD PMID:27121444 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Ces1d carboxylesterase 1D multiple interactions ISO CES1 protein results in increased hydrolysis of and results in increased activity of imidapril; CES1 protein results in increased metabolism of and results in increased activity of imidapril; Dust inhibits the reaction [CES1 protein results in increased metabolism of and results in increased activity of imidapril]; tert-butylphenyl diphenyl phosphate inhibits the reaction [CES1 protein results in increased metabolism of and results in increased activity of imidapril]; triphenyl phosphate inhibits the reaction [CES1 protein results in increased metabolism of and results in increased activity of imidapril] CTD PMID:9300133 PMID:31268531 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 affects response to substance ISO CYP11B2 gene polymorphism affects the susceptibility to imidapril CTD PMID:16765146 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
imidaprilat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions ISO imidaprilat inhibits the reaction [AGT protein results in increased activity of and results in increased localization of PRKCA protein] CTD PMID:16257180 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO imidaprilat inhibits the reaction [AGT protein results in increased activity of and results in increased localization of PRKCA protein] CTD PMID:16257180 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
methylprednisolone succinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ces2h carboxylesterase 2H multiple interactions
increases hydrolysis		 EXP Dexamethasone promotes the reaction [CES2 protein results in increased hydrolysis of Methylprednisolone Hemisuccinate] CTD PMID:15794950 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
mono(2-ethyl-5-hydroxyhexyl) phthalate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam33 ADAM metallopeptidase domain 33 multiple interactions ISO [[Endocrine Disruptors results in increased abundance of mono(2-ethyl-5-hydroxyhexyl) phthalate] which results in increased methylation of ADAM33 intron] which results in increased expression of ADAM33 mRNA CTD PMID:30226539 NCBI chr 3:118,262,395...118,283,461
Ensembl chr 3:118,271,029...118,283,461 		JBrowse link
G Crp C-reactive protein decreases expression ISO mono(2-ethyl-5-hydroxyhexyl) phthalate results in decreased expression of CRP protein CTD PMID:21349512 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions ISO
EXP		 [CYP2C19 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-hydroxyhexyl) phthalate
[CYP2C6V1 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-hydroxyhexyl) phthalate		 CTD PMID:22186153 PMID:23545481 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP
ISO		 [CYP3A2 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-hydroxyhexyl) phthalate
[CYP3A4 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-hydroxyhexyl) phthalate		 CTD PMID:23545481 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Flg filaggrin multiple interactions ISO [FLG gene polymorphism affects the susceptibility to Diethylhexyl Phthalate] which affects the abundance of mono(2-ethyl-5-hydroxyhexyl) phthalate CTD PMID:24380925 NCBI chr 2:178,888,688...178,912,731 JBrowse link
G Mirlet7c1 microRNA let-7c-1 multiple interactions ISO [Diethylhexyl Phthalate results in increased abundance of mono(2-ethyl-5-hydroxyhexyl) phthalate] which affects the expression of MIRLET7C CTD PMID:30481674 NCBI chr11:16,201,163...16,201,256
Ensembl chr11:16,201,158...16,201,265 		JBrowse link
G Shbg sex hormone binding globulin decreases secretion ISO mono(2-ethyl-5-hydroxyhexyl) phthalate results in decreased secretion of SHBG protein CTD PMID:24945889 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057 		JBrowse link
G Tug1 taurine up-regulated 1 affects expression ISO mono(2-ethyl-5-hydroxyhexyl) phthalate affects the expression of TUG1 mRNA CTD PMID:29385630 NCBI chr14:78,519,894...78,526,927
Ensembl chr14:78,522,506...78,526,927 		JBrowse link
mono(2-ethyl-5-oxohexyl) phthalate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acin1 apoptotic chromatin condensation inducer 1 affects expression ISO mono(2-ethyl-5-oxohexyl)phthalate affects the expression of ACIN1 mRNA CTD PMID:34478338 NCBI chr15:28,102,112...28,147,001
Ensembl chr15:28,102,112...28,147,001 		JBrowse link
G Adam33 ADAM metallopeptidase domain 33 multiple interactions ISO [[Endocrine Disruptors results in increased abundance of mono(2-ethyl-5-oxohexyl)phthalate] which results in increased methylation of ADAM33 intron] which results in increased expression of ADAM33 mRNA CTD PMID:30226539 NCBI chr 3:118,262,395...118,283,461
Ensembl chr 3:118,271,029...118,283,461 		JBrowse link
G Ankrd10 ankyrin repeat domain 10 affects expression ISO mono(2-ethyl-5-oxohexyl)phthalate affects the expression of ANKRD10 mRNA CTD PMID:34478338 NCBI chr16:77,866,489...77,889,745
Ensembl chr16:77,864,261...77,889,745 		JBrowse link
G Ap1g2 adaptor related protein complex 1 subunit gamma 2 affects expression ISO mono(2-ethyl-5-oxohexyl)phthalate affects the expression of AP1G2 mRNA CTD PMID:34478338 NCBI chr15:28,571,571...28,579,421
Ensembl chr15:28,571,568...28,589,004 		JBrowse link
G Arglu1 arginine and glutamate rich 1 affects expression ISO mono(2-ethyl-5-oxohexyl)phthalate affects the expression of ARGLU1 mRNA CTD PMID:34478338 NCBI chr16:80,753,300...80,777,350
Ensembl chr16:80,753,315...80,777,349 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO mono(2-ethyl-5-oxohexyl)phthalate results in decreased expression of CCL2 mRNA CTD PMID:32015430 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccnl1 cyclin L1 affects expression ISO mono(2-ethyl-5-oxohexyl)phthalate affects the expression of CCNL1 mRNA CTD PMID:34478338 NCBI chr 2:150,184,865...150,199,524
Ensembl chr 2:150,184,798...150,197,368 		JBrowse link
G Cd68 Cd68 molecule decreases expression ISO mono(2-ethyl-5-oxohexyl)phthalate results in decreased expression of CD68 mRNA CTD PMID:32015430 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697 		JBrowse link
G Clk1 CDC-like kinase 1 affects expression ISO mono(2-ethyl-5-oxohexyl)phthalate affects the expression of CLK1 mRNA CTD PMID:34478338 NCBI chr 9:59,947,774...59,959,002
Ensembl chr 9:59,947,764...59,957,000 		JBrowse link
G Crp C-reactive protein decreases expression ISO mono(2-ethyl-5-oxohexyl)phthalate results in decreased expression of CRP mRNA; mono(2-ethyl-5-oxohexyl)phthalate results in decreased expression of CRP protein CTD PMID:21349512 PMID:32015430 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions ISO
EXP		 [CYP2C19 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-oxohexyl)phthalate
[CYP2C6V1 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-oxohexyl)phthalate		 CTD PMID:22186153 PMID:23545481 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP
ISO		 [CYP3A2 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-oxohexyl)phthalate
[CYP3A4 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-oxohexyl)phthalate		 CTD PMID:23545481 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Flg filaggrin multiple interactions ISO [FLG gene polymorphism affects the susceptibility to Diethylhexyl Phthalate] which affects the abundance of mono(2-ethyl-5-oxohexyl)phthalate CTD PMID:24380925 NCBI chr 2:178,888,688...178,912,731 JBrowse link
G Leng8 leukocyte receptor cluster member 8 affects expression ISO mono(2-ethyl-5-oxohexyl)phthalate affects the expression of LENG8 mRNA CTD PMID:34478338 NCBI chr 1:70,040,785...70,052,662
Ensembl chr 1:70,040,785...70,052,488 		JBrowse link
G Luc7l3 LUC7-like 3 pre-mRNA splicing factor affects expression ISO mono(2-ethyl-5-oxohexyl)phthalate affects the expression of LUC7L3 mRNA CTD PMID:34478338 NCBI chr10:79,240,050...79,276,555
Ensembl chr10:79,240,563...79,276,538 		JBrowse link
G Mirlet7c1 microRNA let-7c-1 multiple interactions ISO [Diethylhexyl Phthalate results in increased abundance of mono(2-ethyl-5-oxohexyl)phthalate] which affects the expression of MIRLET7C CTD PMID:30481674 NCBI chr11:16,201,163...16,201,256
Ensembl chr11:16,201,158...16,201,265 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases activity ISO mono(2-ethyl-5-oxohexyl)phthalate results in increased activity of PPARA protein CTD PMID:28571686 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO mono(2-ethyl-5-oxohexyl)phthalate binds to and affects the folding of and results in increased activity of PPARG protein CTD PMID:30085373 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Rbm6 RNA binding motif protein 6 affects expression ISO mono(2-ethyl-5-oxohexyl)phthalate affects the expression of RBM6 mRNA CTD PMID:34478338 NCBI chr 8:108,452,687...108,552,783
Ensembl chr 8:108,452,687...108,552,771 		JBrowse link
G Shbg sex hormone binding globulin decreases secretion ISO mono(2-ethyl-5-oxohexyl)phthalate results in decreased secretion of SHBG protein CTD PMID:24945889 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057 		JBrowse link
G Son SON DNA and RNA binding protein affects expression ISO mono(2-ethyl-5-oxohexyl)phthalate affects the expression of SON mRNA CTD PMID:34478338 NCBI chr11:30,850,890...30,923,167
Ensembl chr11:30,892,005...30,923,167 		JBrowse link
G Srsf11 serine and arginine rich splicing factor 11 affects expression ISO mono(2-ethyl-5-oxohexyl)phthalate affects the expression of SRSF11 mRNA CTD PMID:34478338 NCBI chr 2:247,074,623...247,101,460
Ensembl chr 2:247,074,631...247,101,425 		JBrowse link
G Tubgcp6 tubulin, gamma complex associated protein 6 affects expression ISO mono(2-ethyl-5-oxohexyl)phthalate affects the expression of TUBGCP6 mRNA CTD PMID:34478338 NCBI chr 7:120,177,686...120,198,986
Ensembl chr 7:120,177,686...120,199,011 		JBrowse link
mono(2-ethylhexyl) phthalate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca12 ATP binding cassette subfamily A member 12 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ABCA12 mRNA CTD PMID:22401849 NCBI chr 9:72,822,661...72,995,748
Ensembl chr 9:72,823,350...72,996,049 		JBrowse link
G Abca4 ATP binding cassette subfamily A member 4 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ABCA4 mRNA CTD PMID:22401849 NCBI chr 2:210,164,813...210,302,069
Ensembl chr 2:210,164,813...210,302,069 		JBrowse link
G Abca7 ATP binding cassette subfamily A member 7 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ABCA7 mRNA CTD PMID:22401849 NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425 		JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ABCB1B mRNA CTD PMID:22401849 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199 		JBrowse link
G Abcb9 ATP binding cassette subfamily B member 9 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ABCB9 mRNA CTD PMID:22401849 NCBI chr12:32,499,225...32,531,932
Ensembl chr12:32,499,225...32,531,931 		JBrowse link
G Abcc10 ATP binding cassette subfamily C member 10 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ABCC10 mRNA CTD PMID:22401849 NCBI chr 9:14,657,242...14,677,178
Ensembl chr 9:14,657,264...14,677,178 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of ABCC2 mRNA CTD PMID:22401849 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ABCC6 mRNA CTD PMID:22401849 NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464 		JBrowse link
G Acaa1b acetyl-Coenzyme A acyltransferase 1B increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ACAA1B mRNA CTD PMID:32522588 NCBI chr 8:118,872,996...118,881,852
Ensembl chr 8:118,872,997...118,881,825 		JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ACAA2 mRNA CTD PMID:32522588 NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249 		JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ACADM mRNA CTD PMID:32522588 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147 		JBrowse link
G Acads acyl-CoA dehydrogenase short chain increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of ACADS mRNA CTD PMID:22087261 NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898 		JBrowse link
G Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ACAP1 mRNA CTD PMID:22401849 NCBI chr10:54,605,323...54,619,472
Ensembl chr10:54,605,323...54,619,472 		JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression EXP
ISO		 mono-(2-ethylhexyl)phthalate results in increased expression of ACOX1 mRNA CTD PMID:22087261 PMID:32522588 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Acoxl acyl-CoA oxidase-like decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ACOXL mRNA CTD PMID:22401849 NCBI chr 3:115,061,045...115,367,032
Ensembl chr 3:115,061,060...115,364,686 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ACSL1 protein CTD PMID:27384973 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541 		JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ACSL4 mRNA CTD PMID:22401849 NCBI chr  X:105,942,794...106,006,573
Ensembl chr  X:105,942,799...106,006,427 		JBrowse link
G Adam22 ADAM metallopeptidase domain 22 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ADAM22 mRNA CTD PMID:22401849 NCBI chr 4:25,716,055...25,970,932
Ensembl chr 4:25,715,990...25,964,962 		JBrowse link
G Adam23 ADAM metallopeptidase domain 23 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ADAM23 mRNA CTD PMID:22401849 NCBI chr 9:64,862,878...65,006,515
Ensembl chr 9:64,862,878...65,006,515 		JBrowse link
G Adamts20 ADAM metallopeptidase with thrombospondin type 1 motif, 20 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ADAMTS20 mRNA CTD PMID:22401849 NCBI chr 7:125,396,227...125,528,020
Ensembl chr 7:125,397,734...125,527,777 		JBrowse link
G Adamts4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ADAMTS4 mRNA CTD PMID:22401849 NCBI chr13:83,670,556...83,680,045
Ensembl chr13:83,670,183...83,680,065 		JBrowse link
G Adarb2 adenosine deaminase, RNA-specific, B2 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ADARB2 mRNA CTD PMID:22401849 NCBI chr17:61,750,437...62,300,984
Ensembl chr17:61,756,067...62,300,831 		JBrowse link
G Adcy4 adenylate cyclase 4 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ADCY4 mRNA CTD PMID:22401849 NCBI chr15:29,266,280...29,282,153
Ensembl chr15:29,266,287...29,282,108 		JBrowse link
G Adcy7 adenylate cyclase 7 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ADCY7 mRNA CTD PMID:22401849 NCBI chr19:18,740,875...18,798,924
Ensembl chr19:18,740,875...18,776,311 		JBrowse link
G Adgre4 adhesion G protein-coupled receptor E4 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ADGRE4 mRNA CTD PMID:22401849 NCBI chr 9:9,758,106...9,901,908
Ensembl chr 9:9,760,355...9,900,760 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ADIPOQ protein CTD PMID:27384973 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Adipor2 adiponectin receptor 2 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ADIPOR2 mRNA CTD PMID:32522588 NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355 		JBrowse link
G Adora1 adenosine A1 receptor decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ADORA1 mRNA CTD PMID:22401849 NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801 		JBrowse link
G Adra1d adrenoceptor alpha 1D decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ADRA1D mRNA CTD PMID:22401849 NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354 		JBrowse link
G Afm afamin increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of AFM mRNA CTD PMID:22401849 NCBI chr14:17,531,026...17,563,868
Ensembl chr14:17,531,024...17,563,870 		JBrowse link
G Agbl3 AGBL carboxypeptidase 3 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of AGBL3 mRNA CTD PMID:22401849 NCBI chr 4:63,448,789...63,535,538
Ensembl chr 4:63,453,940...63,531,188 		JBrowse link
G Agl amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase multiple interactions EXP mono-(2-ethylhexyl)phthalate binds to and affects the activity of AGL protein CTD PMID:19240039 NCBI chr 2:204,705,053...204,760,966
Ensembl chr 2:204,705,053...204,760,828 		JBrowse link
G Agtr1b angiotensin II receptor, type 1b decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of AGTR1B mRNA CTD PMID:22401849 NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232 		JBrowse link
G Ahcy adenosylhomocysteinase decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of AHCY mRNA CTD PMID:22401849 NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393 		JBrowse link
G Ahr aryl hydrocarbon receptor increases expression
affects expression
multiple interactions		 EXP
ISO		 mono-(2-ethylhexyl)phthalate results in increased expression of AHR mRNA
mono-(2-ethylhexyl)phthalate affects the expression of AHR mRNA
[monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] affects the expression of AHR mRNA		 CTD PMID:12706301 PMID:28381288 PMID:31884101 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor multiple interactions ISO [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] affects the expression of AHRR mRNA CTD PMID:31884101 NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673 		JBrowse link
G Ahsg alpha-2-HS-glycoprotein increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of AHSG protein CTD PMID:27384973 NCBI chr11:78,117,903...78,145,956
Ensembl chr11:78,117,918...78,145,999 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression
multiple interactions		 ISO mono-(2-ethylhexyl)phthalate results in increased expression of AIFM1 mRNA
[monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in increased expression of AIFM1 mRNA; Estradiol affects the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of AIFM1 mRNA]		 CTD PMID:24412242 PMID:31884101 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Aifm3 apoptosis inducing factor, mitochondria associated 3 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of AIFM3 mRNA CTD PMID:22401849 NCBI chr11:83,504,859...83,523,630
Ensembl chr11:83,504,861...83,521,248 		JBrowse link
G Ajuba ajuba LIM protein increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of AJUBA mRNA CTD PMID:16809437 NCBI chr15:28,019,775...28,031,537
Ensembl chr15:28,019,778...28,030,021 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
increases activity
affects response to substance		 ISO
EXP		 AKT1 protein affects the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of BCL2L1 mRNA]; AKT1 protein affects the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of BCL2L1 protein]; AKT1 protein affects the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of NFKB1 mRNA]; mono-(2-ethylhexyl)phthalate inhibits the reaction [INS protein results in increased expression of and results in increased phosphorylation of AKT1 protein]
[bisphenol A co-treated with mono-(2-ethylhexyl)phthalate] results in increased phosphorylation of AKT1 protein; HDAC6 protein affects the reaction [[bisphenol A co-treated with mono-(2-ethylhexyl)phthalate] results in increased phosphorylation of AKT1 protein]
mono-(2-ethylhexyl)phthalate inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]
mono-(2-ethylhexyl)phthalate results in increased phosphorylation of AKT1 protein
mono-(2-ethylhexyl)phthalate results in increased activity of AKT1 protein
AKT1 protein affects the susceptibility to mono-(2-ethylhexyl)phthalate		 CTD PMID:18755736 PMID:28526321 PMID:31009676 PMID:34910997 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt1s1 AKT1 substrate 1 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of AKT1S1 mRNA CTD PMID:22401849 NCBI chr 1:95,333,186...95,339,678
Ensembl chr 1:95,332,898...95,339,677 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated decreases expression ISO mono-(2-ethylhexyl)phthalate analog results in decreased expression of ALPL protein; mono-(2-ethylhexyl)phthalate results in decreased expression of ALPL protein CTD PMID:25777084 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Amh anti-Mullerian hormone decreases expression ISO
EXP		 mono-(2-ethylhexyl)phthalate results in decreased expression of AMH mRNA
mono-(2-ethylhexyl)phthalate results in decreased expression of AMH protein		 CTD PMID:19165384 PMID:19440488 NCBI chr 7:8,906,776...8,909,184
Ensembl chr 7:8,906,836...8,909,282 		JBrowse link
G Ank1 ankyrin 1 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ANK1 mRNA CTD PMID:22401849 NCBI chr16:68,876,294...69,054,812
Ensembl chr16:68,877,504...69,054,759 		JBrowse link
G Ano9 anoctamin 9 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ANO9 mRNA CTD PMID:22401849 NCBI chr 1:196,208,863...196,230,381
Ensembl chr 1:196,197,341...196,229,900 		JBrowse link
G Antxr2 ANTXR cell adhesion molecule 2 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ANTXR2 mRNA CTD PMID:22401849 NCBI chr14:11,542,266...11,682,112
Ensembl chr14:11,541,772...11,682,094 		JBrowse link
G Aox1 aldehyde oxidase 1 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of AOX1 mRNA CTD PMID:23360888 NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770 		JBrowse link
G Apln apelin affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of APLN mRNA CTD PMID:32522588 NCBI chr  X:127,180,801...127,213,567
Ensembl chr  X:127,203,823...127,213,391 		JBrowse link
G Apoe apolipoprotein E increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of APOE mRNA CTD PMID:22087261 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Ar androgen receptor multiple interactions ISO mono-(2-ethylhexyl)phthalate inhibits the reaction [cyclopamine results in increased expression of AR]
[monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of AR mRNA		 CTD PMID:26710974 PMID:31884101 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] affects the expression of ARNT mRNA CTD PMID:31884101 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580 		JBrowse link
G Arrb2 arrestin, beta 2 multiple interactions EXP mono-(2-ethylhexyl)phthalate inhibits the reaction [INS1 protein results in increased expression of ARRB2 protein] CTD PMID:28526321 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Arrdc3 arrestin domain containing 3 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ARRDC3 mRNA CTD PMID:24356939 NCBI chr 2:11,137,443...11,149,978
Ensembl chr 2:11,137,460...11,149,978 		JBrowse link
G Artn artemin increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ARTN mRNA CTD PMID:22401849 NCBI chr 5:131,458,596...131,470,193
Ensembl chr 5:131,464,756...131,468,025 		JBrowse link
G Ascc3 activating signal cointegrator 1 complex subunit 3 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ASCC3 mRNA CTD PMID:22401849 NCBI chr20:53,510,137...53,795,446
Ensembl chr20:53,510,184...53,790,165 		JBrowse link
G Atf3 activating transcription factor 3 increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of ATF3 mRNA CTD PMID:16809437 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Atf7ip2 activating transcription factor 7 interacting protein 2 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ATF7IP2 mRNA CTD PMID:22401849 NCBI chr10:5,403,099...5,445,989
Ensembl chr10:5,403,105...5,446,142 		JBrowse link
G Atp12a ATPase H+/K+ transporting non-gastric alpha2 subunit decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ATP12A mRNA CTD PMID:22401849 NCBI chr15:30,443,571...30,468,229
Ensembl chr15:30,443,571...30,468,229 		JBrowse link
G Atp13a4 ATPase 13A4 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ATP13A4 mRNA CTD PMID:22401849 NCBI chr11:71,222,196...71,359,933
Ensembl chr11:71,226,161...71,359,933 		JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ATP1A3 mRNA CTD PMID:22401849 NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918 		JBrowse link
G Atp6v1c2 ATPase H+ transporting V1 subunit C2 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ATP6V1C2 mRNA CTD PMID:22401849 NCBI chr 6:40,080,545...40,144,199
Ensembl chr 6:40,080,547...40,120,028 		JBrowse link
G Atp6v1h ATPase H+ transporting V1 subunit H affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of ATP6V1H mRNA CTD PMID:21195148 NCBI chr 5:14,379,029...14,484,703
Ensembl chr 5:14,378,257...14,537,962 		JBrowse link
G Atp8b4 ATPase phospholipid transporting 8B4 (putative) decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ATP8B4 mRNA CTD PMID:22401849 NCBI chr 3:113,554,979...113,757,635
Ensembl chr 3:113,556,192...113,757,225 		JBrowse link
G Atp9b ATPase phospholipid transporting 9B (putative) increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ATP9B mRNA CTD PMID:22401849 NCBI chr18:74,176,863...74,368,993
Ensembl chr18:74,176,863...74,368,953 		JBrowse link
G Atrnl1 attractin like 1 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ATRNL1 mRNA CTD PMID:22401849 NCBI chr 1:256,670,976...257,219,291
Ensembl chr 1:256,670,627...257,213,197 		JBrowse link
G Avpi1 arginine vasopressin-induced 1 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of AVPI1 mRNA CTD PMID:22401849 NCBI chr 1:240,930,236...240,936,154
Ensembl chr 1:240,930,236...240,936,154 		JBrowse link
G B3galt1 Beta-1,3-galactosyltransferase 1 increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of B3GALT1 mRNA CTD PMID:16809437 NCBI chr 3:52,253,413...52,826,508
Ensembl chr 3:52,253,618...52,825,313 		JBrowse link
G B3galt2 Beta-1,3-galactosyltransferase 2 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of B3GALT2 mRNA CTD PMID:22401849 NCBI chr13:55,389,406...55,398,419
Ensembl chr13:55,389,406...55,398,419 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO mono-(2-ethylhexyl)phthalate results in increased expression of BAX mRNA; mono-(2-ethylhexyl)phthalate results in increased expression of BAX protein
[monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in increased expression of BAX mRNA		 CTD PMID:12927354 PMID:24706461 PMID:26597031 PMID:31884101 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Baz1a bromodomain adjacent to zinc finger domain, 1A decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of BAZ1A mRNA CTD PMID:22401849 NCBI chr 6:72,389,701...72,512,516
Ensembl chr 6:72,389,703...72,512,459 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of BBC3 protein CTD PMID:24706461 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO mono-(2-ethylhexyl)phthalate results in decreased expression of BCL2 mRNA; mono-(2-ethylhexyl)phthalate results in decreased expression of BCL2 protein
MIR16-1 mRNA affects the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of BCL2 protein]
[mono-(2-ethylhexyl)phthalate co-treated with Estradiol] results in decreased expression of BCL2 mRNA; [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] affects the expression of BCL2 mRNA		 CTD PMID:12927354 PMID:24412242 PMID:24706461 PMID:26597031 PMID:31884101 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
increases expression		 ISO AKT1 protein affects the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of BCL2L1 mRNA]; AKT1 protein affects the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of BCL2L1 protein]
mono-(2-ethylhexyl)phthalate results in increased expression of BCL2L1 mRNA; mono-(2-ethylhexyl)phthalate results in increased expression of BCL2L1 protein		 CTD PMID:18755736 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bcl2l10 Bcl2-like 10 multiple interactions
decreases expression		 ISO [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of BCL2L10 mRNA; Estradiol affects the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of BCL2L10 mRNA] CTD PMID:24412242 PMID:31884101 NCBI chr 8:76,107,326...76,113,373
Ensembl chr 8:76,107,326...76,113,367 		JBrowse link
G Bcl6 BCL6, transcription repressor increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of BCL6 mRNA CTD PMID:16809437 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
G Bean1 brain expressed, associated with NEDD4, 1 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of BEAN1 mRNA CTD PMID:22401849 NCBI chr19:739,551...786,122
Ensembl chr19:739,551...787,537 		JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of BHMT mRNA CTD PMID:22401849 NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742 		JBrowse link
G Bicra BRD4 interacting chromatin remodeling complex associated protein decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of BICRA mRNA CTD PMID:22401849 NCBI chr 1:76,661,897...76,736,146
Ensembl chr 1:76,661,897...76,737,157 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in increased expression of BID mRNA CTD PMID:31884101 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK decreases expression
multiple interactions		 ISO mono-(2-ethylhexyl)phthalate results in decreased expression of BOK mRNA
[monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of BOK mRNA		 CTD PMID:24412242 PMID:31884101 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476 		JBrowse link
G Bpifb6 BPI fold containing family B, member 6 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of BPIFB6 mRNA CTD PMID:22401849 NCBI chr 3:142,383,701...142,395,308
Ensembl chr 3:142,381,374...142,395,308 		JBrowse link
G Brd3 bromodomain containing 3 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of BRD3 mRNA CTD PMID:22401849 NCBI chr 3:10,773,163...10,829,675
Ensembl chr 3:10,775,272...10,829,577 		JBrowse link
G Brsk1 BR serine/threonine kinase 1 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of BRSK1 mRNA CTD PMID:22401849 NCBI chr 1:69,134,166...69,159,947
Ensembl chr 1:69,134,565...69,160,365 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of BTG2 mRNA CTD PMID:16809437 NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628 		JBrowse link
G Bves blood vessel epicardial substance decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of BVES mRNA CTD PMID:22401849 NCBI chr20:48,819,241...48,860,282
Ensembl chr20:48,822,308...48,857,472 		JBrowse link
G C1qtnf6 C1q and TNF related 6 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of C1QTNF6 mRNA CTD PMID:22401849 NCBI chr 7:110,077,867...110,084,584
Ensembl chr 7:110,077,878...110,084,412 		JBrowse link
G C8a complement C8 alpha chain increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of C8A mRNA CTD PMID:22401849 NCBI chr 5:119,583,168...119,637,675
Ensembl chr 5:119,583,174...119,637,754 		JBrowse link
G Cabp1 calcium binding protein 1 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of CABP1 mRNA CTD PMID:22401849 NCBI chr12:41,385,234...41,448,930
Ensembl chr12:41,378,897...41,448,927 		JBrowse link
G Cadm1 cell adhesion molecule 1 affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of CADM1 mRNA CTD PMID:21195148 NCBI chr 8:47,847,836...48,178,703
Ensembl chr 8:47,847,325...48,182,833 		JBrowse link
G Camk1d calcium/calmodulin-dependent protein kinase ID increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of CAMK1D mRNA CTD PMID:22401849 NCBI chr17:72,581,899...72,982,704
Ensembl chr17:72,581,979...72,980,556 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
increases expression		 ISO
EXP		 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [PPARG protein promotes the reaction [mono-(2-ethylhexyl)phthalate results in increased activity of CASP3 protein]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [PPARG protein promotes the reaction [mono-(2-ethylhexyl)phthalate results in increased activity of CASP3 protein]]; PPARG protein promotes the reaction [mono-(2-ethylhexyl)phthalate results in increased activity of CASP3 protein]; rosiglitazone promotes the reaction [PPARG protein promotes the reaction [mono-(2-ethylhexyl)phthalate results in increased activity of CASP3 protein]]
mono-(2-ethylhexyl)phthalate results in increased cleavage of CASP3 protein
[monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CASP3 mRNA
mono-(2-ethylhexyl)phthalate results in increased expression of CASP3 protein		 CTD PMID:12927354 PMID:19165384 PMID:19720108 PMID:23360888 PMID:24706461 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases activity ISO mono-(2-ethylhexyl)phthalate results in increased activity of CASP7 protein CTD PMID:23360888 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CASP8 mRNA CTD PMID:31884101 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity ISO mono-(2-ethylhexyl)phthalate results in increased activity of CASP9 protein CTD PMID:24706461 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions
increases activity
increases expression		 EXP
ISO		 Cycloheximide inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of CAT protein]
mono-(2-ethylhexyl)phthalate results in increased activity of CAT protein
[monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in increased expression of CAT mRNA		 CTD PMID:2306265 PMID:6845354 PMID:31884101 PMID:32522588 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cbr1 carbonyl reductase 1 multiple interactions ISO [mono-(2-ethylhexyl)phthalate co-treated with Genistein] results in increased expression of CBR1 mRNA CTD PMID:34942354 NCBI chr11:32,860,618...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393 		JBrowse link
G Cbr1l1 carbonyl reductase 1 like 1 multiple interactions ISO [mono-(2-ethylhexyl)phthalate co-treated with Genistein] results in increased expression of CBR1 mRNA CTD PMID:34942354 NCBI chr11:32,876,563...32,884,234 JBrowse link
G Cbs cystathionine beta synthase affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of CBS mRNA CTD PMID:21195148 NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764 		JBrowse link
G Ccdc27 coiled-coil domain containing 27 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of CCDC27 mRNA CTD PMID:22401849 NCBI chr 5:164,585,285...164,599,391
Ensembl chr 5:164,585,267...164,599,355 		JBrowse link
G Ccdc96 coiled-coil domain containing 96 affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of CCDC96 mRNA CTD PMID:21195148 NCBI chr14:74,276,568...74,279,072
Ensembl chr14:74,276,960...74,278,888 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of CCL2 mRNA CTD PMID:27384973 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccn1 cellular communication network factor 1 increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of CCN1 mRNA CTD PMID:16809437 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484 		JBrowse link
G Ccn2 cellular communication network factor 2 increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of CCN2 mRNA CTD PMID:16809437 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccna2 cyclin A2 multiple interactions ISO [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CCNA2 mRNA CTD PMID:31884101 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CCNB1 mRNA CTD PMID:31884101 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnb2 cyclin B2 multiple interactions ISO [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CCNB2 mRNA CTD PMID:31884101 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874 		JBrowse link
G Ccnd1 cyclin D1 affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of CCND1 mRNA CTD PMID:21195148 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnd2 cyclin D2 decreases expression
multiple interactions		 ISO mono-(2-ethylhexyl)phthalate results in decreased expression of CCND2 mRNA
Estradiol inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of CCND2 mRNA]		 CTD PMID:19874833 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495 		JBrowse link
G Ccnd3 cyclin D3 multiple interactions ISO [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CCND3 mRNA CTD PMID:31884101 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371 		JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CCNE1 mRNA CTD PMID:31884101 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Ccno cyclin O affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of CCNO mRNA CTD PMID:21195148 NCBI chr 2:44,630,640...44,633,914
Ensembl chr 2:44,626,369...44,633,914 		JBrowse link
G Ccr7 C-C motif chemokine receptor 7 multiple interactions ISO [bisphenol A co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-benzyl phthalate co-treated with monobutyl phthalate] results in increased expression of CCR7 mRNA CTD PMID:30398665 NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309 		JBrowse link
G Ccrl2 C-C motif chemokine receptor like 2 increases expression
decreases expression		 EXP
ISO		 mono-(2-ethylhexyl)phthalate results in increased expression of CCRL2 mRNA
mono-(2-ethylhexyl)phthalate results in decreased expression of CCRL2 mRNA		 CTD PMID:16809437 PMID:22401849 NCBI chr 8:111,034,279...111,036,914
Ensembl chr 8:111,034,279...111,036,664 		JBrowse link
G Cd109 CD109 molecule affects expression
decreases expression		 ISO mono-(2-ethylhexyl)phthalate affects the expression of CD109 mRNA
mono-(2-ethylhexyl)phthalate results in decreased expression of CD109 mRNA		 CTD PMID:21195148 PMID:22401849 NCBI chr 8:79,454,480...79,569,195
Ensembl chr 8:79,454,480...79,569,194 		JBrowse link
G Cd163 CD163 molecule increases expression
multiple interactions		 ISO mono-(2-ethylhexyl)phthalate results in increased expression of CD163 protein
[bisphenol A co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-benzyl phthalate co-treated with monobutyl phthalate] results in decreased expression of CD163 mRNA
mono-(2-ethylhexyl)phthalate inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CD163 mRNA]		 CTD PMID:22143055 PMID:29718165 PMID:30398665 NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878 		JBrowse link
G Cd24 CD24 molecule affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of CD24A mRNA CTD PMID:21195148 NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662 		JBrowse link
G Cd36 CD36 molecule multiple interactions
increases expression		 ISO mono-(2-ethylhexyl)phthalate inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CD36 mRNA]
mono-(2-ethylhexyl)phthalate results in increased expression of CD36 mRNA		 CTD PMID:29718165 PMID:35421560 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Cd40 CD40 molecule affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of CD40 mRNA CTD PMID:21195148 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cd69 Cd69 molecule increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of CD69 mRNA CTD PMID:16809437 NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542 		JBrowse link
G Cdh2 cadherin 2 multiple interactions EXP [Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [mono-(2-ethylhexyl)phthalate affects the localization of CDH2 protein]; mono-(2-ethylhexyl)phthalate results in increased expression of and affects the localization of CDH2 protein CTD PMID:29940330 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Cdh23 cadherin-related 23 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of CDH23 mRNA CTD PMID:22401849 NCBI chr20:28,240,643...28,622,490
Ensembl chr20:28,240,645...28,622,419 		JBrowse link
G Cdhr2 cadherin-related family member 2 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of CDHR2 mRNA CTD PMID:22401849 NCBI chr17:9,876,853...9,913,356
Ensembl chr17:9,876,860...9,912,575 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CDK2 mRNA CTD PMID:31884101 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression
multiple interactions		 ISO mono-(2-ethylhexyl)phthalate results in decreased expression of CDK4 mRNA
[monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CDK4 mRNA; Estradiol inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of CDK4 mRNA]		 CTD PMID:19874833 PMID:31884101 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
multiple interactions
increases activity		 ISO mono-(2-ethylhexyl)phthalate results in decreased expression of CDKN1A mRNA
[monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in increased expression of CDKN1A mRNA
Selenomethionine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased activity of CDKN1A protein]; Sodium Selenite inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased activity of CDKN1A protein]		 CTD PMID:21515331 PMID:22401849 PMID:31884101 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CDKN1B mRNA CTD PMID:31884101 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C multiple interactions ISO [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CDKN1C mRNA CTD PMID:31884101 NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions ISO [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in increased expression of CDKN2A mRNA CTD PMID:31884101 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B multiple interactions ISO [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in increased expression of CDKN2B mRNA CTD PMID:31884101 NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050 		JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C multiple interactions ISO [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CDKN2C mRNA CTD PMID:31884101 NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278 		JBrowse link
G Cdkn2d cyclin dependent kinase inhibitor 2D multiple interactions ISO [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] affects the expression of CDKN2D mRNA CTD PMID:31884101 NCBI chr 8:19,831,874...19,834,640
Ensembl chr 8:19,831,866...19,834,674 		JBrowse link
G Cdo1 cysteine dioxygenase type 1 increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of CDO1 mRNA CTD PMID:16809437 NCBI chr18:39,432,473...39,447,253
Ensembl chr18:39,432,474...39,447,296 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression
increases expression
multiple interactions		 ISO
EXP		 mono-(2-ethylhexyl)phthalate results in decreased expression of CEBPA protein
mono-(2-ethylhexyl)phthalate results in increased expression of CEBPA mRNA
Colforsin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of CEBPA protein]		 CTD PMID:21832167 PMID:25543134 PMID:27384973 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of CEBPB mRNA CTD PMID:25543134 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Celsr2 cadherin, EGF LAG seven-pass G-type receptor 2 multiple interactions
increases phosphorylation
affects transport		 ISO [IC 261 results in decreased activity of CSNK1A1 protein] inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased phosphorylation of CELSR2 protein]
mono-(2-ethylhexyl)phthalate affects the transport of CELSR2 protein		 CTD PMID:16484285 NCBI chr 2:196,029,206...196,053,848
Ensembl chr 2:196,029,434...196,053,845 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions ISO [FASL affects the susceptibility to mono-(2-ethylhexyl)phthalate] which affects the expression of CFLAR protein CTD PMID:20100735 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Cga glycoprotein hormones, alpha polypeptide multiple interactions
affects expression
increases expression
increases secretion		 ISO mono-(2-ethylhexyl)phthalate inhibits the reaction [CGA protein results in increased abundance of Estradiol]
mono-(2-ethylhexyl)phthalate affects the expression of CGA mRNA
mono-(2-ethylhexyl)phthalate results in increased expression of CGA mRNA
mono-(2-ethylhexyl)phthalate results in increased secretion of CGA protein
mono-(2-ethylhexyl)phthalate inhibits the reaction [CGA protein results in increased abundance of Progesterone]		 CTD PMID:19501113 PMID:27181934 PMID:28381288 PMID:29089286 NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191 		JBrowse link
G Chat choline O-acetyltransferase increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of CHAT mRNA CTD PMID:21145954 NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093 		JBrowse link
G Chd5 chromodomain helicase DNA binding protein 5 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of CHD5 mRNA CTD PMID:22401849 NCBI chr 5:162,848,273...162,898,997
Ensembl chr 5:162,848,394...162,896,291 		JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions
increases phosphorylation		 ISO gingerol inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased phosphorylation of CHEK2 protein] CTD PMID:28988496 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Chrd chordin affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of CHRD mRNA CTD PMID:21195148 NCBI chr11:80,171,994...80,181,166
Ensembl chr11:80,171,994...80,180,673 		JBrowse link
G Chrna9 cholinergic receptor nicotinic alpha 9 subunit affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of CHRNA9 mRNA CTD PMID:21195148 NCBI chr14:42,235,218...42,241,939
Ensembl chr14:42,235,226...42,242,192 		JBrowse link
G Cidea cell death-inducing DFFA-like effector a increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of CIDEA mRNA CTD PMID:32522588 NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481 		JBrowse link
G Clasp2 cytoplasmic linker associated protein 2 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of CLASP2 mRNA CTD PMID:22401849 NCBI chr 8:113,677,345...113,859,957
Ensembl chr 8:113,677,284...113,858,731 		JBrowse link
G Cldn18 claudin 18 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of CLDN18 mRNA CTD PMID:22401849 NCBI chr 8:100,246,499...100,265,797
Ensembl chr 8:100,247,633...100,273,351 		JBrowse link
G Cldn6 claudin 6 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of CLDN6 mRNA CTD PMID:22321834 NCBI chr10:12,710,302...12,713,987
Ensembl chr10:12,709,960...12,715,973 		JBrowse link
G Clstn3 calsyntenin 3 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of CLSTN3 mRNA CTD PMID:22401849 NCBI chr 4:157,331,494...157,364,769
Ensembl chr 4:157,331,494...157,364,769 		JBrowse link
G Cmtm2a CKLF-like MARVEL transmembrane domain containing 2A decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of CMTM2B mRNA CTD PMID:22401849 NCBI chr19:671,719...678,839
Ensembl chr19:671,719...678,837 		JBrowse link
G Cnga2 cyclic nucleotide gated channel subunit alpha 2 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of CNGA2 mRNA CTD PMID:22401849 NCBI chr  X:149,696,999...149,715,051
Ensembl chr  X:149,696,997...149,715,051 		JBrowse link
G Cnga4 cyclic nucleotide gated channel subunit alpha 4 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of CNGA4 mRNA CTD PMID:22401849 NCBI chr 1:159,752,357...159,756,369
Ensembl chr 1:159,752,357...159,756,375 		JBrowse link
G Cntn3 contactin 3 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of CNTN3 mRNA CTD PMID:22401849 NCBI chr 4:134,841,268...135,214,460
Ensembl chr 4:134,842,266...135,125,613 		JBrowse link
G Cntnap5b contactin associated protein family member 5B decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of CNTNAP5A mRNA CTD PMID:22401849 NCBI chr13:17,863,367...18,766,983
Ensembl chr13:18,093,420...18,761,014 		JBrowse link
G Cntrl centriolin increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of CNTRL mRNA CTD PMID:22401849 NCBI chr 3:18,428,147...18,500,362
Ensembl chr 3:18,428,103...18,500,380 		JBrowse link
G Col12a1 collagen type XII alpha 1 chain decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of COL12A1 mRNA CTD PMID:22401849 NCBI chr 8:80,547,592...80,665,665
Ensembl chr 8:80,547,593...80,665,686 		JBrowse link
G Col25a1 collagen type XXV alpha 1 chain increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of COL25A1 mRNA CTD PMID:22401849 NCBI chr 2:218,755,152...219,154,348
Ensembl chr 2:218,755,691...219,153,501 		JBrowse link
G Col2a1 collagen type II alpha 1 chain increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of COL2A1 mRNA CTD PMID:22401849 NCBI chr 7:129,098,489...129,127,620
Ensembl chr 7:129,098,786...129,127,546 		JBrowse link
G Col4a6 collagen type IV alpha 6 chain increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of COL4A6 mRNA CTD PMID:22401849 NCBI chr  X:104,766,463...105,117,499
Ensembl chr  X:104,766,957...105,117,500 		JBrowse link
G Cox7a1 cytochrome c oxidase subunit 7A1 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of COX7A1 mRNA CTD PMID:32522588 NCBI chr 1:85,422,162...85,447,530
Ensembl chr 1:85,441,871...85,445,151 		JBrowse link
G Cpa5 carboxypeptidase A5 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of CPA5 mRNA CTD PMID:22401849 NCBI chr 4:59,229,754...59,249,503
Ensembl chr 4:59,230,964...59,249,490 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression
affects expression		 ISO mono-(2-ethylhexyl)phthalate results in decreased expression of CPT1A mRNA
mono-(2-ethylhexyl)phthalate affects the expression of CPT1A mRNA		 CTD PMID:22401849 PMID:32522588 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of CPT2 mRNA CTD PMID:32522588 NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095 		JBrowse link
G Crhbp corticotropin releasing hormone binding protein decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of CRHBP mRNA CTD PMID:22401849 NCBI chr 2:26,692,403...26,704,710
Ensembl chr 2:26,692,403...26,704,710 		JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of CRHR2 mRNA CTD PMID:22401849 NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904 		JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 multiple interactions ISO [IC 261 results in decreased activity of CSNK1A1 protein] inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased phosphorylation of CELSR2 protein] CTD PMID:16484285 NCBI chr18:55,017,049...55,050,184
Ensembl chr18:55,017,055...55,049,271 		JBrowse link
G Cth cystathionine gamma-lyase affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of CTH mRNA CTD PMID:21195148 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234 		JBrowse link
G Ctnnb1 catenin beta 1 increases expression
multiple interactions		 ISO
EXP		 mono-(2-ethylhexyl)phthalate results in increased expression of CTNNB1 mRNA
[Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [mono-(2-ethylhexyl)phthalate affects the localization of CTNNB1 protein]; mono-(2-ethylhexyl)phthalate results in increased expression of and affects the localization of CTNNB1 protein		 CTD PMID:22321834 PMID:29940330 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Ctsl cathepsin L increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of CTSL mRNA CTD PMID:16809437 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548 		JBrowse link
G Cubn cubilin decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of CUBN mRNA CTD PMID:22401849 NCBI chr17:76,385,046...76,593,133
Ensembl chr17:76,385,060...76,593,231 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of CXCL1 mRNA CTD PMID:16809437 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression
multiple interactions		 EXP
ISO		 mono-(2-ethylhexyl)phthalate results in increased expression of CXCL10 mRNA
[bisphenol A co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-benzyl phthalate co-treated with monobutyl phthalate] results in increased expression of CXCL10 mRNA		 CTD PMID:16809437 PMID:30398665 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of CXCL1 mRNA CTD PMID:27384973 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cyc1 cytochrome c-1 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of CYC1 mRNA CTD PMID:32522588 NCBI chr 7:108,067,106...108,069,483
Ensembl chr 7:108,067,115...108,069,479 		JBrowse link
G Cycs cytochrome c, somatic affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of CYCS mRNA CTD PMID:32522588 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases activity
increases expression
multiple interactions
decreases expression		 EXP
ISO		 mono-(2-ethylhexyl)phthalate results in increased activity of CYP11A1 protein
mono-(2-ethylhexyl)phthalate results in increased expression of CYP11A1 mRNA
[Genistein co-treated with mono-(2-ethylhexyl)phthalate] results in increased expression of CYP11A1 mRNA; [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CYP11A1 mRNA
mono-(2-ethylhexyl)phthalate results in decreased expression of CYP11A1 mRNA; mono-(2-ethylhexyl)phthalate results in decreased expression of CYP11A1 protein		 CTD PMID:22401849 PMID:22525294 PMID:27181934 PMID:29089286 PMID:31884101 More... NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression
multiple interactions
decreases expression
affects expression		 EXP
ISO		 mono-(2-ethylhexyl)phthalate results in increased expression of CYP17A1 mRNA
[monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CYP17A1 mRNA
mono-(2-ethylhexyl)phthalate results in decreased expression of CYP17A1 mRNA; mono-(2-ethylhexyl)phthalate results in decreased expression of CYP17A1 protein
mono-(2-ethylhexyl)phthalate affects the expression of CYP17A1		 CTD PMID:16809437 PMID:19560483 PMID:22087261 PMID:31884101 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity
multiple interactions
increases expression
decreases expression		 ISO
EXP		 mono-(2-ethylhexyl)phthalate results in decreased activity of CYP19A1 protein
[monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CYP19A1 mRNA
mono-(2-ethylhexyl)phthalate results in increased expression of CYP19A1 mRNA
alitretinoin promotes the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of CYP19A1 mRNA]
mono-(2-ethylhexyl)phthalate inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]		 CTD PMID:12706301 PMID:19501113 PMID:19822197 PMID:19874833 PMID:22401849 More... NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
decreases expression
multiple interactions		 ISO mono-(2-ethylhexyl)phthalate results in increased expression of CYP1A1 mRNA
mono-(2-ethylhexyl)phthalate results in decreased expression of CYP1A1 mRNA
[monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in increased expression of CYP1A1 mRNA		 CTD PMID:15521013 PMID:31884101 PMID:34954075 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
decreases expression
multiple interactions		 EXP
ISO		 mono-(2-ethylhexyl)phthalate results in increased expression of CYP1B1 mRNA
mono-(2-ethylhexyl)phthalate results in decreased expression of CYP1B1 mRNA
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of CYP1B1 mRNA]; [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CYP1B1 mRNA		 CTD PMID:12706301 PMID:31884101 PMID:34954075 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases activity EXP mono-(2-ethylhexyl)phthalate results in decreased activity of CYP2C11 protein CTD PMID:27432241 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions
increases metabolic processing		 EXP
ISO		 [CYP2C6V1 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-hydroxyhexyl) phthalate; [CYP2C6V1 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-oxohexyl)phthalate; [CYP2C6V1 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of phthalic acid
[CYP2C19 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-hydroxyhexyl) phthalate; [CYP2C19 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-oxohexyl)phthalate		 CTD PMID:22186153 PMID:23545481 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression
increases metabolic processing		 EXP
ISO		 [CYP3A2 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-hydroxyhexyl) phthalate; [CYP3A2 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-oxohexyl)phthalate; [CYP3A2 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of phthalic acid
[CYP3A4 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-hydroxyhexyl) phthalate; [CYP3A4 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-oxohexyl)phthalate; [CYP3A4 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of phthalic acid; [Dexamethasone co-treated with mono-(2-ethylhexyl)phthalate] results in increased activity of CYP3A4 protein
mono-(2-ethylhexyl)phthalate results in increased expression of CYP3A4 mRNA		 CTD PMID:18332045 PMID:22186153 PMID:23545481 PMID:27551952 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity EXP mono-(2-ethylhexyl)phthalate results in decreased activity of CYP3A62 protein CTD PMID:27432241 NCBI chr12:16,397,998...16,433,833
Ensembl chr12:16,397,998...16,433,833 		JBrowse link
G Cyp51 cytochrome P450, family 51 decreases expression EXP mono-(2-ethylhexyl)phthalate results in decreased expression of CYP51 mRNA CTD PMID:22087261 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410 		JBrowse link
G Dach1 dachshund family transcription factor 1 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of DACH1 mRNA CTD PMID:22401849 NCBI chr15:74,528,122...74,909,811
Ensembl chr15:74,529,208...74,909,922 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of DDIT3 mRNA CTD PMID:22321834 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Ddx4 DEAD-box helicase 4 decreases expression EXP mono-(2-ethylhexyl)phthalate results in decreased expression of DDX4 mRNA CTD PMID:30476341 NCBI chr 2:44,227,946...44,282,867
Ensembl chr 2:44,227,946...44,282,723 		JBrowse link
G Derl3 derlin 3 affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of DERL3 mRNA CTD PMID:21195148 NCBI chr20:12,754,490...12,768,454
Ensembl chr20:12,763,543...12,767,027 		JBrowse link
G Dgkb diacylglycerol kinase, beta decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of DGKB mRNA CTD PMID:22401849 NCBI chr 6:54,640,948...55,397,210
Ensembl chr 6:54,641,614...55,397,043 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of DHCR24 mRNA CTD PMID:23360888 NCBI chr 5:121,344,637...121,368,853
Ensembl chr 5:121,344,575...121,371,137 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase affects expression
decreases expression		 EXP
ISO		 mono-(2-ethylhexyl)phthalate affects the expression of DHCR7; mono-(2-ethylhexyl)phthalate affects the expression of DHCR7 mRNA
mono-(2-ethylhexyl)phthalate results in decreased expression of DHCR7 mRNA		 CTD PMID:16809437 PMID:19560483 PMID:22401849 NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055 		JBrowse link
G Dhrs4 dehydrogenase/reductase 4 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of DHRS4 protein CTD PMID:27384973 NCBI chr15:28,966,544...28,978,135
Ensembl chr15:28,966,553...28,978,127 		JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein increases expression
decreases expression		 ISO mono-(2-ethylhexyl)phthalate results in increased expression of DIABLO protein
mono-(2-ethylhexyl)phthalate results in decreased expression of DIABLO mRNA		 CTD PMID:18755736 PMID:24706461 NCBI chr12:33,055,784...33,070,400
Ensembl chr12:33,055,263...33,070,387 		JBrowse link
G Dipk2a divergent protein kinase domain 2A increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of DIPK2A mRNA CTD PMID:16809437 NCBI chr 8:95,070,695...95,089,815
Ensembl chr 8:95,030,279...95,089,815 		JBrowse link
G Disp3 dispatched RND transporter family member 3 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of DISP3 mRNA CTD PMID:22401849 NCBI chr 5:158,672,015...158,720,806
Ensembl chr 5:158,672,015...158,720,806 		JBrowse link
G Dmd dystrophin increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of DMD mRNA CTD PMID:22401849 NCBI chr  X:47,272,324...49,504,219
Ensembl chr  X:47,272,331...49,504,207 		JBrowse link
G Dmp1 dentin matrix acidic phosphoprotein 1 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of DMP1 mRNA CTD PMID:25777084 NCBI chr14:5,528,441...5,542,078
Ensembl chr14:5,528,431...5,539,323 		JBrowse link
G Dnah14 dynein axonemal heavy chain 14 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of DNAH14 mRNA CTD PMID:22401849 NCBI chr13:93,322,653...93,540,706
Ensembl chr13:93,322,711...93,538,646 		JBrowse link
G Dnah8 dynein, axonemal, heavy chain 8 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of DNAH8 mRNA CTD PMID:22401849 NCBI chr20:8,692,939...8,946,780
Ensembl chr20:8,692,963...8,946,772 		JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of DNAJB1 mRNA CTD PMID:24356939 NCBI chr19:24,522,717...24,526,458
Ensembl chr19:24,522,717...24,526,458 		JBrowse link
G Dnmt1 DNA methyltransferase 1 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of DNMT1 mRNA CTD PMID:22401849 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659 		JBrowse link
G Dock10 dedicator of cytokinesis 10 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of DOCK10 mRNA CTD PMID:22401849 NCBI chr 9:81,843,599...82,101,540
Ensembl chr 9:81,843,604...82,101,525 		JBrowse link
G Dock5 dedicator of cytokinesis 5 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of DOCK5 mRNA CTD PMID:22401849 NCBI chr15:41,979,728...42,158,733
Ensembl chr15:41,979,729...42,158,649 		JBrowse link
G Dpep1 dipeptidase 1 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of DPEP1 mRNA CTD PMID:22401849 NCBI chr19:51,209,831...51,237,004
Ensembl chr19:51,219,660...51,235,257 		JBrowse link
G Dpep2 dipeptidase 2 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of DPEP2 mRNA CTD PMID:22401849 NCBI chr19:33,883,557...33,896,487
Ensembl chr19:33,885,478...33,891,954 		JBrowse link
G Dpp6 dipeptidyl peptidase like 6 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of DPP6 mRNA CTD PMID:22401849 NCBI chr 4:7,589,386...8,508,666
Ensembl chr 4:7,591,009...8,508,532 		JBrowse link
G Dpy19l1 dpy-19 like C-mannosyltransferase 1 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of DPY19L1 mRNA CTD PMID:22401849 NCBI chr 8:22,933,163...23,021,461
Ensembl chr 8:22,933,163...23,021,751 		JBrowse link
G Dpysl4 dihydropyrimidinase-like 4 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of DPYSL4 mRNA CTD PMID:22401849 NCBI chr 1:193,883,039...193,898,916
Ensembl chr 1:193,883,106...193,898,914 		JBrowse link
G Dsc2 desmocollin 2 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of DSC2 mRNA CTD PMID:22401849 NCBI chr18:11,450,392...11,482,476
Ensembl chr18:11,450,390...11,482,392 		JBrowse link
G Dst dystonin increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of DST mRNA CTD PMID:22401849 NCBI chr 9:36,135,657...36,529,617
Ensembl chr 9:36,135,284...36,529,615 		JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression
decreases expression		 EXP
ISO		 mono-(2-ethylhexyl)phthalate results in increased expression of DUSP1 mRNA
mono-(2-ethylhexyl)phthalate results in decreased expression of DUSP1 mRNA		 CTD PMID:16809437 PMID:22401849 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Dusp5 dual specificity phosphatase 5 increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of DUSP5 mRNA CTD PMID:16809437 NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818 		JBrowse link
G Dusp6 dual specificity phosphatase 6 increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of DUSP6 mRNA CTD PMID:16809437 NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185 		JBrowse link
G Ebf3 EBF transcription factor 3 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of EBF3 mRNA CTD PMID:22401849 NCBI chr 1:191,996,726...192,114,713
Ensembl chr 1:191,996,730...192,114,359 		JBrowse link
G Ebp EBP, cholestenol delta-isomerase increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of EBP mRNA CTD PMID:22087261 NCBI chr  X:14,299,427...14,305,826
Ensembl chr  X:14,299,448...14,305,826 		JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ECH1 mRNA CTD PMID:32522588 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795 		JBrowse link
G Eci1 enoyl-CoA delta isomerase 1 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ECI1 mRNA CTD PMID:32522588 NCBI chr10:13,456,715...13,470,061
Ensembl chr10:13,456,563...13,470,061 		JBrowse link
G Ecm1 extracellular matrix protein 1 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ECM1 mRNA CTD PMID:22401849 NCBI chr 2:183,287,491...183,292,729
Ensembl chr 2:183,287,322...183,292,671 		JBrowse link
G Edn1 endothelin 1 increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of EDN1 mRNA CTD PMID:16809437 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Efcab10 EF-hand calcium binding domain 10 affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of EFCAB10 mRNA CTD PMID:21195148 NCBI chr 6:50,004,479...50,011,398
Ensembl chr 6:50,004,479...50,011,398 		JBrowse link
G Efhd1 EF-hand domain family, member D1 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of EFHD1 mRNA CTD PMID:22401849 NCBI chr 9:87,938,259...87,984,917
Ensembl chr 9:87,938,284...87,984,917 		JBrowse link
G Efnb2 ephrin B2 increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of EFNB2 mRNA CTD PMID:16809437 NCBI chr16:80,783,389...80,827,420
Ensembl chr16:80,783,417...80,824,391 		JBrowse link
G Egf epidermal growth factor decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of EGF mRNA CTD PMID:22401849 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egr1 early growth response 1 increases expression EXP
ISO		 mono-(2-ethylhexyl)phthalate results in increased expression of EGR1 mRNA CTD PMID:8764118 PMID:16809437 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Egr3 early growth response 3 increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of EGR3 mRNA CTD PMID:16809437 NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627 		JBrowse link
G Egr4 early growth response 4 increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of EGR4 mRNA CTD PMID:16809437 NCBI chr 4:118,047,869...118,050,328
Ensembl chr 4:118,047,869...118,050,328 		JBrowse link
G Eif5b eukaryotic translation initiation factor 5B increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of EIF5B mRNA CTD PMID:22401849 NCBI chr 9:40,222,769...40,277,482
Ensembl chr 9:40,222,898...40,277,482 		JBrowse link
G Elf1 E74 like ETS transcription factor 1 increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of ELF1 mRNA CTD PMID:16809437 NCBI chr15:54,890,644...54,986,721
Ensembl chr15:54,865,616...54,986,699 		JBrowse link
G Enox1 ecto-NOX disulfide-thiol exchanger 1 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ENOX1 mRNA CTD PMID:22401849 NCBI chr15:52,517,833...53,079,752
Ensembl chr15:52,515,178...53,079,749 		JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO mono-(2-ethylhexyl)phthalate promotes the reaction [PPARA protein binds to EP300 protein] CTD PMID:20123618 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Epb41l1 erythrocyte membrane protein band 4.1-like 1 affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of EPB41L1 mRNA CTD PMID:21195148 NCBI chr 3:144,929,195...145,052,723
Ensembl chr 3:144,984,640...145,052,721 		JBrowse link
G Epb41l3 erythrocyte membrane protein band 4.1-like 3 affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of EPB41L3 mRNA CTD PMID:21195148 NCBI chr 9:109,056,178...109,260,607
Ensembl chr 9:109,016,113...109,260,607 		JBrowse link
G Epdr1 ependymin related 1 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of EPDR1 mRNA CTD PMID:22401849 NCBI chr17:45,333,677...45,358,597
Ensembl chr17:45,333,956...45,358,594 		JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of EPHX1 mRNA CTD PMID:12706301 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G Ephx2 epoxide hydrolase 2 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of EPHX2 mRNA CTD PMID:22401849 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ERBB4 mRNA CTD PMID:22401849 NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595 		JBrowse link
G Ern2 endoplasmic reticulum to nucleus signaling 2 multiple interactions ISO mono-(2-ethylhexyl)phthalate promotes the reaction [INS protein results in increased phosphorylation of ERN2 protein] CTD PMID:31009676 NCBI chr 1:176,726,454...176,743,289
Ensembl chr 1:176,726,454...176,743,289 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
affects expression
increases expression		 ISO [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of ESR1 mRNA; mono-(2-ethylhexyl)phthalate binds to and results in increased activity of ESR1 protein
mono-(2-ethylhexyl)phthalate affects the expression of ESR1 mRNA
ESR1 protein affects the reaction [mono-(2-ethylhexyl)phthalate affects the expression of ESR1 mRNA]; ESR1 protein affects the reaction [mono-(2-ethylhexyl)phthalate affects the expression of MMP2 mRNA]; ESR1 protein affects the reaction [mono-(2-ethylhexyl)phthalate affects the expression of MMP9 mRNA]; ESR1 protein affects the reaction [mono-(2-ethylhexyl)phthalate affects the expression of TIMP2 mRNA]; ESR1 protein affects the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of PCNA mRNA]; mono-(2-ethylhexyl)phthalate binds to and results in increased activity of ESR1 protein
mono-(2-ethylhexyl)phthalate results in increased expression of ESR1 protein		 CTD PMID:20209442 PMID:31884101 PMID:33049310 PMID:33631300 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO mono-(2-ethylhexyl)phthalate binds to and results in increased activity of ESR2 protein
[monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of ESR2 mRNA		 CTD PMID:31884101 PMID:33049310 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G F10 coagulation factor X decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of F10 mRNA CTD PMID:22401849 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141 		JBrowse link
G F3 coagulation factor III, tissue factor increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of F3 mRNA CTD PMID:16809437 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Fabp3 fatty acid binding protein 3 increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of FABP3 mRNA; mono-(2-ethylhexyl)phthalate results in increased expression of FABP3 protein CTD PMID:12706301 PMID:15647598 NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718 		JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression
multiple interactions		 ISO mono-(2-ethylhexyl)phthalate analog results in increased expression of FABP4 mRNA; mono-(2-ethylhexyl)phthalate results in increased expression of FABP4 mRNA; mono-(2-ethylhexyl)phthalate results in increased expression of FABP4 protein
T 0070907 inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of FABP4 mRNA]		 CTD PMID:25543134 PMID:25777084 PMID:27384973 PMID:35421560 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Fads6 fatty acid desaturase 6 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of FADS6 mRNA CTD PMID:22401849 NCBI chr10:100,522,981...100,538,181
Ensembl chr10:100,522,981...100,538,181 		JBrowse link
G Faim2 Fas apoptotic inhibitory molecule 2 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of FAIM2 mRNA CTD PMID:22401849 NCBI chr 7:130,632,368...130,659,353
Ensembl chr 7:130,633,348...130,659,168