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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dicarboxylic acid monoester
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Accession:CHEBI:36244 term browser browse the term
Definition:A monoester of a dicarboxylic acid.
Synonyms:related_synonym: dicarboxylic acid monoesters
 cyclic_relationship: is_conjugate_acid_of CHEBI:131605


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artesunate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions
decreases expression
ISO Deferoxamine inhibits the reaction [Artesunate results in decreased expression of ACTA2 mRNA]
Artesunate results in decreased expression of ACTA2 mRNA; Artesunate results in decreased expression of ACTA2 protein
Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]
CTD PMID:30551460 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects localization ISO artesunate affects the localization of AIFM1 protein CTD PMID:24704559 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Ar androgen receptor multiple interactions ISO artesunate binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Atg12 autophagy related 12 increases expression ISO Artesunate results in increased expression of ATG12 mRNA CTD PMID:30551460 NCBI chr18:40,721,799...40,732,143
Ensembl chr18:40,721,800...40,732,126
JBrowse link
G Atg3 autophagy related 3 increases expression ISO Artesunate results in increased expression of ATG3 mRNA CTD PMID:30551460 NCBI chr11:60,585,192...60,613,706
Ensembl chr11:60,585,171...60,613,718
JBrowse link
G Atg5 autophagy related 5 increases expression ISO Artesunate results in increased expression of ATG5 mRNA CTD PMID:30551460 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO
EXP
Artesunate results in increased expression of BAX protein
[1,2-Dimethylhydrazine co-treated with artesunate] results in increased expression of BAX protein
CTD PMID:24704559 PMID:29031619 PMID:33002460 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO
EXP
Artesunate results in decreased expression of BCL2 protein
3-methyladenine inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; acadesine promotes the reaction [Artesunate results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; dorsomorphin inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; Sirolimus promotes the reaction [Artesunate results in decreased expression of BCL2 protein]
[1,2-Dimethylhydrazine co-treated with artesunate] results in decreased expression of BCL2 protein
CTD PMID:24704559 PMID:29031619 PMID:33002460 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bst1 bone marrow stromal cell antigen 1 increases response to substance ISO BST1 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr14:71,798,218...71,814,540
Ensembl chr14:71,798,651...71,814,523
JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
multiple interactions
ISO artesunate results in increased activity of CASP3 protein
Artesunate results in increased cleavage of CASP3 protein
3-methyladenine inhibits the reaction [Artesunate results in increased cleavage of CASP3 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Artesunate results in increased cleavage of CASP3 protein]; Sirolimus promotes the reaction [Artesunate results in increased cleavage of CASP3 protein]
CTD PMID:19513562 PMID:24704559 PMID:33002460 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 affects expression ISO artesunate affects the expression of CASP9 protein CTD PMID:24704559 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase increases expression
decreases response to substance
ISO artesunate results in increased expression of CAT protein
CAT protein results in decreased susceptibility to artesunate
CTD PMID:19513562 PMID:20144594 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cct2 chaperonin containing TCP1 subunit 2 decreases response to substance ISO CCT2 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 7:60,106,532...60,122,779
Ensembl chr 7:60,109,974...60,122,805
JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions
increases phosphorylation
ISO APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK1 protein] CTD PMID:31664825 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions
increases phosphorylation
ISO APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK2 protein] CTD PMID:31664825 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Clip4 CAP-GLY domain containing linker protein family, member 4 increases response to substance ISO CLIP4 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 6:23,222,020...23,316,962
Ensembl chr 6:23,222,021...23,316,962
JBrowse link
G Coq8a coenzyme Q8A decreases response to substance ISO COQ8A mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr13:98,451,629...98,480,438
Ensembl chr13:98,451,637...98,480,419
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CTNNB1 protein] CTD PMID:29031619 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Dbh dopamine beta-hydroxylase increases response to substance ISO DBH mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898
JBrowse link
G Des desmin multiple interactions
decreases expression
ISO Deferoxamine inhibits the reaction [Artesunate results in decreased expression of DES mRNA]
Artesunate results in decreased expression of DES mRNA; Artesunate results in decreased expression of DES protein
CTD PMID:30551460 NCBI chr 9:82,556,574...82,564,288
Ensembl chr 9:82,556,573...82,564,294
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO artesunate binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO artesunate results in increased expression of FAS protein CTD PMID:19513562 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Flna filamin A increases response to substance ISO FLNA mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr  X:156,460,785...156,487,245
Ensembl chr  X:156,463,953...156,487,245
JBrowse link
G Fn1 fibronectin 1 multiple interactions
decreases expression
ISO Deferoxamine inhibits the reaction [Artesunate results in decreased expression of FN1 mRNA]
Artesunate results in decreased expression of FN1 mRNA; Artesunate results in decreased expression of FN1 protein
CTD PMID:30551460 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fth1 ferritin heavy chain 1 decreases expression
multiple interactions
ISO Artesunate results in decreased expression of FTH1 mRNA; Artesunate results in decreased expression of FTH1 protein
Chloroquine inhibits the reaction [Artesunate results in decreased expression of FTH1 mRNA]
CTD PMID:30551460 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G Fzd7 frizzled class receptor 7 increases response to substance ISO FZD7 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 9:66,305,731...66,308,550
Ensembl chr 9:66,305,731...66,308,550
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit affects response to substance
decreases response to substance
ISO GCLC mRNA affects the susceptibility to artesunate
GCLC mRNA results in decreased susceptibility to artesunate
CTD PMID:15796179 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit decreases response to substance ISO GCLM mRNA results in decreased susceptibility to artesunate CTD PMID:15796179 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gpx4 glutathione peroxidase 4 decreases activity
multiple interactions
ISO Artesunate results in decreased activity of GPX4 protein
Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of GPX4 protein]
CTD PMID:30551460 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
JBrowse link
G Gstm4 glutathione S-transferase mu 4 affects response to substance ISO GSTM4 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr 2:210,834,013...210,839,242
Ensembl chr 2:210,833,884...210,839,295
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression ISO artesunate results in decreased expression of GSTP1 protein CTD PMID:19513562 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gstt2 glutathione S-transferase, theta 2 affects response to substance ISO GSTT2 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr20:13,760,810...13,764,481
Ensembl chr20:13,760,810...13,764,475
JBrowse link
G Gstz1 glutathione S-transferase zeta 1 affects response to substance ISO GSTZ1 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr 6:111,176,798...111,187,246
Ensembl chr 6:111,176,798...111,187,244
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Artesunate inhibits the reaction [Ethanol results in increased expression of IL1B protein]; Artesunate inhibits the reaction [Glucose results in increased expression of IL1B mRNA]; Artesunate inhibits the reaction [Glucose results in increased secretion of IL1B protein] CTD PMID:27474069 PMID:30031708 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Artesunate inhibits the reaction [Ethanol results in increased expression of IL6 protein]; Artesunate inhibits the reaction [Glucose results in increased expression of IL6 mRNA]; Artesunate inhibits the reaction [Glucose results in increased secretion of IL6 protein] CTD PMID:27474069 PMID:30031708 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgb1 integrin subunit beta 1 increases response to substance ISO ITGB1 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases lipidation
ISO 3-methyladenine inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; acadesine promotes the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; dorsomorphin inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; Sirolimus promotes the reaction [Artesunate results in increased lipidation of MAP1LC3B protein] CTD PMID:33002460 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 affects response to substance ISO MGST3 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr13:85,601,499...85,622,392
Ensembl chr13:85,601,499...85,622,314
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions EXP artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MKI67 protein] CTD PMID:29031619 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
EXP
ISO
artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MMP9 protein]
Chloroquine inhibits the reaction [Artesunate results in decreased expression of MMP9 mRNA]
CTD PMID:29031619 PMID:30551460 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP artesunate inhibits the reaction [Ethanol results in increased activity of MPO protein] CTD PMID:27474069 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase decreases response to substance ISO MTHFD2 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 4:115,004,433...115,015,965
Ensembl chr 4:115,004,448...115,015,965
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation
ISO acadesine promotes the reaction [Artesunate results in decreased phosphorylation of MTOR protein]; Acetylcysteine inhibits the reaction [Artesunate results in decreased phosphorylation of MTOR protein]; dorsomorphin inhibits the reaction [Artesunate results in decreased phosphorylation of MTOR protein] CTD PMID:33002460 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions EXP artesunate inhibits the reaction [Glucose results in increased expression of MYD88 protein] CTD PMID:30031708 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Naca nascent polypeptide associated complex subunit alpha decreases response to substance ISO NACA mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 7:2,458,283...2,470,674
Ensembl chr 7:2,458,264...2,470,674
JBrowse link
G Nckap1 NCK-associated protein 1 increases response to substance ISO NCKAP1 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 3:67,725,180...67,804,680
Ensembl chr 3:67,725,947...67,787,990
JBrowse link
G Ncoa4 nuclear receptor coactivator 4 multiple interactions
decreases expression
ISO Chloroquine inhibits the reaction [Artesunate results in decreased expression of NCOA4 mRNA]
Artesunate results in decreased expression of NCOA4 mRNA; Artesunate results in decreased expression of NCOA4 protein
CTD PMID:30551460 NCBI chr16:8,302,950...8,323,294
Ensembl chr16:8,302,950...8,323,293
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization ISO artesunate affects the localization of NFE2L2 protein CTD PMID:26340163 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP artesunate inhibits the reaction [Glucose results in increased expression of NLRP3 protein] CTD PMID:30031708 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO Artesunate results in increased cleavage of PARP1 protein
3-methyladenine inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; acadesine promotes the reaction [Artesunate results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; dorsomorphin inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; Sirolimus promotes the reaction [Artesunate results in increased cleavage of PARP1 protein]
CTD PMID:24704559 PMID:33002460 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein] CTD PMID:29031619 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pgr progesterone receptor multiple interactions ISO artesunate binds to and results in increased activity of PGR protein CTD PMID:25752796 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Carbon Tetrachloride results in increased susceptibility to Artesunate] which results in increased expression of PTGS2 mRNA; [Carbon Tetrachloride results in increased susceptibility to Artesunate] which results in increased expression of PTGS2 protein CTD PMID:30551460 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP artesunate inhibits the reaction [Ethanol results in increased expression of RELA protein]; artesunate inhibits the reaction [Glucose results in increased phosphorylation of RELA protein] CTD PMID:27474069 PMID:30031708 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rpa2 replication protein A2 increases phosphorylation ISO Artesunate results in increased phosphorylation of RPA2 protein CTD PMID:31664825 NCBI chr 5:150,957,041...150,967,597
Ensembl chr 5:150,957,001...150,968,269
JBrowse link
G Rpl41 ribosomal protein L41 decreases response to substance ISO RPL41 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 7:2,972,897...2,973,977
Ensembl chr 7:2,972,900...2,973,977
JBrowse link
G Rpl6 ribosomal protein L6 decreases response to substance ISO RPL6 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr12:40,877,578...40,882,032
Ensembl chr12:40,877,613...40,881,124
JBrowse link
G Rpl7 ribosomal protein L7 decreases response to substance ISO RPL7 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 5:2,633,517...2,636,525
Ensembl chr 5:2,632,712...2,640,021
JBrowse link
G Rps12 ribosomal protein S12 decreases response to substance ISO RPS12 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 1:22,758,214...22,760,370
Ensembl chr 1:22,758,212...22,760,370
JBrowse link
G Rps15a ribosomal protein S15a decreases response to substance ISO RPS15A mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 1:187,759,865...187,766,734
Ensembl chr 1:187,759,480...187,766,709
JBrowse link
G Rps6 ribosomal protein S6 decreases response to substance ISO RPS6 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148
Ensembl chr 5:105,197,857...105,200,148
JBrowse link
G Slc25a19 solute carrier family 25 member 19 decreases response to substance ISO SLC25A19 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr10:104,166,594...104,179,523
Ensembl chr10:104,166,598...104,179,523
JBrowse link
G Sp1 Sp1 transcription factor decreases expression ISO artesunate results in decreased expression of SP1 protein CTD PMID:19513562 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
decreases expression
ISO Chloroquine inhibits the reaction [Artesunate results in decreased expression of SQSTM1 protein]
Artesunate results in decreased expression of SQSTM1 mRNA; Artesunate results in decreased expression of SQSTM1 protein
CTD PMID:30551460 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Srsf2 serine and arginine rich splicing factor 2 decreases response to substance ISO SRSF2 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr10:105,792,779...105,795,986
Ensembl chr10:105,792,779...105,795,958
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression
multiple interactions
ISO Artesunate results in increased expression of TIMP1 mRNA
Chloroquine inhibits the reaction [Artesunate results in increased expression of TIMP1 mRNA]
CTD PMID:30551460 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP artesunate inhibits the reaction [Glucose results in increased expression of TLR4 protein] CTD PMID:30031708 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP artesunate inhibits the reaction [Ethanol results in increased expression of TNF protein]; artesunate inhibits the reaction [Glucose results in increased expression of TNF mRNA]; artesunate inhibits the reaction [Glucose results in increased secretion of TNF protein] CTD PMID:27474069 PMID:30031708 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
ISO Artesunate results in increased expression of TP53 protein
Artesunate inhibits the reaction [TPT1 protein binds to TP53 protein]
CTD PMID:33259807 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 affects response to substance
multiple interactions
ISO TPT1 protein affects the susceptibility to artesunate
Artesunate binds to and results in decreased expression of TPT1 protein; Artesunate inhibits the reaction [TPT1 protein binds to TP53 protein]
CTD PMID:15878303 PMID:33259807 NCBI chr15:57,891,680...57,894,504
Ensembl chr15:57,891,680...57,894,504
JBrowse link
G Tufm Tu translation elongation factor, mitochondrial decreases response to substance ISO TUFM mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 1:197,903,582...197,907,189
Ensembl chr 1:197,903,582...197,907,189
JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 increases phosphorylation
multiple interactions
ISO Artesunate results in increased phosphorylation of ULK1 protein
acadesine promotes the reaction [Artesunate results in increased phosphorylation of ULK1 protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased phosphorylation of ULK1 protein]; dorsomorphin inhibits the reaction [Artesunate results in increased phosphorylation of ULK1 protein]
CTD PMID:33002460 NCBI chr12:51,908,105...51,934,704
Ensembl chr12:51,908,448...51,934,702
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of VEGFA protein] CTD PMID:29031619 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Yy1 YY1 transcription factor decreases expression ISO artesunate results in decreased expression of YY1 protein CTD PMID:19513562 NCBI chr 6:132,702,443...132,726,848
Ensembl chr 6:132,702,448...132,727,046
JBrowse link
G Zbtb4 zinc finger and BTB domain containing 4 increases response to substance ISO ZBTB4 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr10:56,367,586...56,388,296
Ensembl chr10:56,381,813...56,385,960
JBrowse link
benazepril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases activity
affects response to substance
ISO benazepril results in decreased activity of ACE protein
ACE gene polymorphism affects the susceptibility to benazepril
CTD PMID:8359184 PMID:11007831 PMID:12652327 PMID:12848919 PMID:15498266 PMID:15555355 PMID:15788353 PMID:15793787 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Ace2 angiotensin I converting enzyme 2 affects response to substance
increases response to substance
multiple interactions
ISO ACE2 gene SNP affects the susceptibility to benazepril
ACE2 gene SNP results in increased susceptibility to benazepril
[AGT gene polymorphism co-treated with ACE2 gene polymorphism] affects the susceptibility to benazepril
CTD PMID:20559404 PMID:21449848 PMID:27121444 NCBI chr  X:32,050,734...32,095,860
Ensembl chr  X:32,049,931...32,096,016
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP [irbesartan co-treated with benazepril] results in decreased expression of ACTA2 protein; benazepril inhibits the reaction [Doxorubicin results in increased expression of ACTA2 mRNA] CTD PMID:15149348 PMID:20493835 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Adrb2 adrenoceptor beta 2 affects response to substance ISO ADRB2 protein polymorphism affects the susceptibility to benazepril CTD PMID:15554460 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Ager advanced glycosylation end product-specific receptor decreases expression EXP benazepril results in decreased expression of AGER mRNA; benazepril results in decreased expression of AGER protein CTD PMID:19018797 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
JBrowse link
G Agt angiotensinogen decreases expression
multiple interactions
affects response to substance
ISO
EXP
benazepril results in decreased expression of AGT protein; benazepril results in decreased expression of AGT protein modified form
benazepril inhibits the reaction [Doxorubicin results in increased expression of AGT protein modified form]; benazepril inhibits the reaction [Particulate Matter results in increased expression of AGT protein modified form]; benazepril inhibits the reaction [Streptozocin results in increased expression of AGT protein modified form]
AGT gene SNP affects the susceptibility to benazepril
[AGT gene polymorphism co-treated with ACE2 gene polymorphism] affects the susceptibility to benazepril; [AGT gene polymorphism co-treated with AGTR1 gene polymorphism] affects the susceptibility to benazepril; [benazepril co-treated with Valsartan] results in decreased expression of AGT protein modified form; Valsartan inhibits the reaction [benazepril results in decreased expression of AGT protein]
CTD PMID:10515446 PMID:11501062 PMID:11798627 PMID:12676074 PMID:17177138 PMID:17261659 PMID:18390891 PMID:19018797 PMID:20718632 PMID:20844835 PMID:21449848 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions
decreases expression
EXP
ISO
benazepril inhibits the reaction [Doxorubicin results in increased expression of AGTR1 protein]
benazepril results in decreased expression of AGTR1A mRNA; benazepril results in decreased expression of AGTR1A protein
[AGT gene polymorphism co-treated with AGTR1 gene polymorphism] affects the susceptibility to benazepril
CTD PMID:9596920 PMID:15157388 PMID:21449848 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor decreases expression
multiple interactions
ISO benazepril results in decreased expression of AMBP protein
benazepril promotes the reaction [Losartan results in decreased expression of AMBP protein]; Losartan promotes the reaction [benazepril results in decreased expression of AMBP protein]
CTD PMID:16303729 NCBI chr 5:78,975,690...78,986,021
Ensembl chr 5:78,975,678...78,985,990
JBrowse link
G Apob apolipoprotein B multiple interactions ISO [Valsartan co-treated with benazepril] results in decreased expression of APOB protein; fluvastatin promotes the reaction [[Valsartan co-treated with benazepril] results in decreased expression of APOB protein] CTD PMID:20671225 NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997
JBrowse link
G Aqp1 aquaporin 1 multiple interactions EXP benazepril inhibits the reaction [Glucose results in increased expression of AQP1 mRNA] CTD PMID:11510275 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360
JBrowse link
G Aqp4 aquaporin 4 multiple interactions EXP benazepril inhibits the reaction [Glucose results in increased expression of AQP4 mRNA] CTD PMID:11510275 NCBI chr18:6,766,009...6,782,757
Ensembl chr18:6,765,945...6,782,996
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression EXP benazepril results in decreased expression of BAX protein CTD PMID:20026869 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP benazepril results in increased expression of BCL2 protein CTD PMID:20026869 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bdkrb2 bradykinin receptor B2 increases activity
multiple interactions
ISO
EXP
benazepril results in increased activity of BDKRB2 protein
[icatibant results in decreased activity of BDKRB2 protein] which results in decreased susceptibility to benazepril
CTD PMID:15339989 PMID:16982965 NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP benazepril inhibits the reaction [Estrogens deficiency results in increased expression of CCL2 protein]; benazepril inhibits the reaction [Ethylene Glycol results in increased expression of CCL2 protein] CTD PMID:16284884 PMID:19553526 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions EXP benazepril inhibits the reaction [Estrogens deficiency results in increased expression of CCL3 protein] CTD PMID:19553526 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions EXP benazepril inhibits the reaction [Ethylene Glycol results in increased expression of CCL5 protein] CTD PMID:16284884 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression EXP benazepril results in decreased expression of CCN2 mRNA CTD PMID:17121042 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Cd36 CD36 molecule increases expression EXP benazepril results in increased expression of CD36 mRNA CTD PMID:14871019 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Col4a1 collagen type IV alpha 1 chain decreases expression
multiple interactions
EXP benazepril results in decreased expression of COL4A1 mRNA
benazepril inhibits the reaction [Streptozocin results in increased expression of COL4A1 mRNA]
CTD PMID:11798618 PMID:16191423 NCBI chr16:83,522,162...83,632,153
Ensembl chr16:83,522,162...83,632,153
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions EXP benazepril inhibits the reaction [Estrogens deficiency results in increased expression of CXCL1 protein] CTD PMID:19553526 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 affects response to substance ISO CYP11B2 gene polymorphism affects the susceptibility to benazepril CTD PMID:16765146 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Edn1 endothelin 1 decreases expression
multiple interactions
increases activity
EXP benazepril results in decreased expression of EDN1 mRNA; benazepril results in decreased expression of EDN1 protein
[Valsartan co-treated with benazepril] results in decreased expression of EDN1 protein
benazepril results in increased activity of EDN1 protein
CTD PMID:7528292 PMID:11136700 PMID:16191423 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 increases expression EXP benazepril results in increased expression of EGLN3 mRNA CTD PMID:14871019 NCBI chr 6:75,050,329...75,075,795
Ensembl chr 6:75,050,329...75,075,795
JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP benazepril inhibits the reaction [Doxorubicin results in increased expression of FAS protein]; benazepril promotes the reaction [Valsartan inhibits the reaction [Doxorubicin results in increased expression of FAS protein]]; Valsartan promotes the reaction [benazepril inhibits the reaction [Doxorubicin results in increased expression of FAS protein]] CTD PMID:15315341 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand multiple interactions EXP benazepril inhibits the reaction [Doxorubicin results in increased expression of FASLG protein]; benazepril promotes the reaction [Valsartan inhibits the reaction [Doxorubicin results in increased expression of FASLG protein]]; Valsartan promotes the reaction [benazepril inhibits the reaction [Doxorubicin results in increased expression of FASLG protein]] CTD PMID:15315341 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fn1 fibronectin 1 decreases expression
multiple interactions
EXP benazepril results in decreased expression of FN1 mRNA; benazepril results in decreased expression of FN1 protein
benazepril inhibits the reaction [Doxorubicin results in increased expression of FN1 protein]; benazepril inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]
CTD PMID:10515446 PMID:11798618 PMID:16191423 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP benazepril results in increased expression of FOS mRNA CTD PMID:8539265 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 increases expression EXP benazepril results in increased expression of GOT2 mRNA CTD PMID:14871019 NCBI chr19:9,587,637...9,613,323
Ensembl chr19:9,587,653...9,613,340
JBrowse link
G Hgf hepatocyte growth factor increases expression EXP benazepril results in increased expression of HGF mRNA CTD PMID:16696918 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 increases expression EXP benazepril results in increased expression of HSPE1 mRNA CTD PMID:14871019 NCBI chr 9:61,691,246...61,724,948
Ensembl chr 9:61,692,154...61,694,599
JBrowse link
G Il6 interleukin 6 multiple interactions EXP benazepril inhibits the reaction [Ethylene Glycol results in increased expression of IL6 protein] CTD PMID:16284884 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Kng2 kininogen 2 multiple interactions
increases expression
EXP benazepril promotes the reaction [Valsartan results in increased expression of KNG1 protein modified form]; PD 123319 inhibits the reaction [benazepril promotes the reaction [Valsartan results in increased expression of KNG1 protein modified form]]; PD 123319 inhibits the reaction [Valsartan promotes the reaction [benazepril results in increased expression of KNG1 protein modified form]]; Valsartan promotes the reaction [benazepril results in increased expression of KNG1 protein modified form] CTD PMID:11509473 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression EXP benazepril results in increased expression of MAPK1 mRNA CTD PMID:14871019 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Me1 malic enzyme 1 increases expression EXP benazepril results in increased expression of ME1 mRNA CTD PMID:14871019 NCBI chr 8:94,256,830...94,368,834
Ensembl chr 8:94,256,839...94,368,834
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP benazepril inhibits the reaction [Doxorubicin results in decreased expression of MMP2 mRNA]; benazepril inhibits the reaction [Doxorubicin results in decreased expression of MMP2 protein]; benazepril inhibits the reaction [Streptozocin results in decreased expression of MMP2 mRNA]; benazepril inhibits the reaction [Streptozocin results in decreased expression of MMP2 protein] CTD PMID:16732983 PMID:19357873 PMID:20821936 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
increases activity
multiple interactions
ISO
EXP
benazepril results in decreased expression of MMP9 protein
benazepril results in increased activity of MMP9 protein
benazepril inhibits the reaction [Doxorubicin results in decreased expression of MMP9 mRNA]; benazepril inhibits the reaction [Doxorubicin results in decreased expression of MMP9 protein]
CTD PMID:15339989 PMID:19357873 PMID:20981132 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mthfr methylenetetrahydrofolate reductase affects response to substance ISO MTHFR gene polymorphism affects the susceptibility to benazepril; MTHFR gene SNP affects the susceptibility to benazepril CTD PMID:16081343 PMID:20445573 NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase affects response to substance ISO MTR gene SNP affects the susceptibility to benazepril; MTR protein polymorphism affects the susceptibility to benazepril CTD PMID:15148588 PMID:20445573 NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression EXP benazepril results in increased expression of MYC mRNA CTD PMID:8539265 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Myh6 myosin heavy chain 6 multiple interactions EXP [Valsartan co-treated with benazepril] results in increased expression of MYH6 mRNA CTD PMID:11136700 NCBI chr15:33,605,653...33,629,730
Ensembl chr15:33,605,654...33,629,699
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 decreases expression EXP benazepril results in decreased expression of NCF1 mRNA CTD PMID:19018797 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP benazepril inhibits the reaction [Ethylene Glycol results in increased expression of NFKB1 protein] CTD PMID:16284884 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP benazepril inhibits the reaction [Streptozocin results in decreased expression of NFKBIA mRNA] CTD PMID:17900838 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression EXP benazepril results in decreased expression of NOS2 mRNA; benazepril results in decreased expression of NOS2 protein CTD PMID:16191423 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nppa natriuretic peptide A multiple interactions
decreases expression
EXP [Valsartan co-treated with benazepril] results in decreased expression of NPPA mRNA
benazepril results in decreased expression of NPPA mRNA
CTD PMID:8763405 PMID:11136700 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nppb natriuretic peptide B multiple interactions
decreases expression
EXP [Valsartan co-treated with benazepril] results in decreased expression of NPPB mRNA
benazepril results in decreased expression of NPPB mRNA
CTD PMID:11136700 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO benazepril inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression EXP benazepril results in decreased expression of PCNA protein CTD PMID:17121042 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression EXP benazepril results in increased expression of PDK4 mRNA CTD PMID:14871019 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
G Pla2g5 phospholipase A2, group V decreases expression EXP benazepril results in decreased expression of PLA2G5 mRNA CTD PMID:14871019 NCBI chr 5:157,247,601...157,268,968
Ensembl chr 5:157,247,781...157,268,903
JBrowse link
G Plau plasminogen activator, urokinase multiple interactions EXP benazepril inhibits the reaction [Streptozocin results in increased expression of PLAU mRNA] CTD PMID:15322501 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
G Plaur plasminogen activator, urokinase receptor multiple interactions EXP benazepril inhibits the reaction [Streptozocin results in increased expression of PLAUR mRNA] CTD PMID:15322501 NCBI chr 1:81,328,171...81,344,954
Ensembl chr 1:81,328,183...81,344,708
JBrowse link
G Plg plasminogen increases activity
multiple interactions
ISO benazepril results in increased activity of PLG protein
FR 173657 inhibits the reaction [benazepril results in increased activity of PLG protein]
CTD PMID:15339989 NCBI chr 1:48,521,828...48,563,895
Ensembl chr 1:48,521,772...48,563,776
JBrowse link
G Prcp prolylcarboxypeptidase affects response to substance ISO PRCP gene SNP affects the susceptibility to benazepril CTD PMID:20079160 NCBI chr 1:157,701,089...157,750,177
Ensembl chr 1:157,701,089...157,750,169
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression
decreases phosphorylation
EXP benazepril inhibits the reaction [Doxorubicin results in increased expression of RELA mRNA]; benazepril inhibits the reaction [Streptozocin results in increased expression of RELA mRNA]
benazepril results in decreased expression of RELA mRNA; benazepril results in decreased expression of RELA protein
benazepril results in decreased phosphorylation of RELA protein
CTD PMID:15157388 PMID:17900838 PMID:19018797 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ren renin increases expression
increases activity
multiple interactions
ISO
EXP
benazepril results in increased expression of REN protein
benazepril results in increased activity of REN protein
[benazepril co-treated with Valsartan] results in increased activity of REN protein
CTD PMID:1316404 PMID:10836730 PMID:11501062 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 decreases expression EXP benazepril results in decreased expression of RSAD2 mRNA CTD PMID:14871019 NCBI chr 6:45,655,947...45,669,083
Ensembl chr 6:45,655,954...45,669,148
JBrowse link
G Serpine1 serpin family E member 1 decreases expression
multiple interactions
ISO
EXP
benazepril results in decreased expression of SERPINE1 mRNA; benazepril results in decreased expression of SERPINE1 protein
FR 173657 inhibits the reaction [benazepril results in decreased expression of SERPINE1 mRNA]
benazepril inhibits the reaction [Streptozocin results in increased expression of SERPINE1 mRNA]
CTD PMID:15322501 PMID:15339989 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Serpinh1 serpin family H member 1 increases expression EXP benazepril results in increased expression of SERPINH1 mRNA CTD PMID:14871019 NCBI chr 1:164,301,010...164,308,306
Ensembl chr 1:164,301,010...164,308,317
JBrowse link
G Slc15a1 solute carrier family 15 member 1 multiple interactions ISO benazepril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr15:106,800,081...106,844,668
Ensembl chr15:106,800,081...106,844,426
JBrowse link
G Slc15a2 solute carrier family 15 member 2 multiple interactions ISO
EXP
benazepril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr11:66,932,664...66,961,708
Ensembl chr11:66,932,614...66,961,713
JBrowse link
G Smad2 SMAD family member 2 affects expression
multiple interactions
EXP benazepril affects the expression of SMAD2 mRNA; benazepril affects the expression of SMAD2 protein
[benazepril co-treated with irbesartan] affects the expression of SMAD2 mRNA; [benazepril co-treated with irbesartan] affects the expression of SMAD2 protein
CTD PMID:16635409 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Smad3 SMAD family member 3 affects expression
multiple interactions
EXP benazepril affects the expression of SMAD3 mRNA; benazepril affects the expression of SMAD3 protein
[benazepril co-treated with candesartan] results in decreased expression of SMAD3 protein; [benazepril co-treated with irbesartan] affects the expression of SMAD3 mRNA; [benazepril co-treated with irbesartan] affects the expression of SMAD3 protein
CTD PMID:16635409 PMID:19487956 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Snrpn small nuclear ribonucleoprotein polypeptide N decreases expression EXP benazepril results in decreased expression of SNRPN mRNA CTD PMID:14871019 NCBI chr 1:195,074,328...195,096,460
Ensembl chr 1:195,074,330...195,096,460
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO [benazepril co-treated with Valsartan] results in increased expression of SOD1 protein CTD PMID:20445533 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression EXP benazepril results in decreased expression of SPP1 mRNA CTD PMID:11867951 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions
affects expression
ISO
EXP
benazepril results in decreased expression of TGFB1 protein
benazepril results in decreased expression of TGFB1 mRNA; benazepril results in decreased expression of TGFB1 protein
[benazepril co-treated with candesartan] results in decreased expression of TGFB1 protein; [benazepril co-treated with Irbesartan] affects the expression of TGFB1 mRNA; benazepril inhibits the reaction [Doxorubicin results in increased expression of TGFB1 mRNA]; benazepril inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; benazepril inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; benazepril inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]
benazepril affects the expression of TGFB1 mRNA
[benazepril co-treated with Valsartan] results in decreased expression of TGFB1 protein
CTD PMID:10515446 PMID:11798627 PMID:11867951 PMID:16191423 PMID:16409969 PMID:16523407 PMID:16635409 PMID:17177138 PMID:18390891 PMID:19018797 PMID:19487956 PMID:20493835 PMID:20844835 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 multiple interactions EXP benazepril inhibits the reaction [Streptozocin results in increased expression of TGFBR1 mRNA]; benazepril inhibits the reaction [Streptozocin results in increased expression of TGFBR1 protein] CTD PMID:11798618 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 decreases expression
multiple interactions
EXP benazepril results in decreased expression of TIMP1 mRNA; benazepril results in decreased expression of TIMP1 protein
benazepril inhibits the reaction [Doxorubicin results in increased expression of TIMP1 mRNA]; benazepril inhibits the reaction [Doxorubicin results in increased expression of TIMP1 protein]
CTD PMID:11867951 PMID:18471418 PMID:19357873 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions EXP benazepril inhibits the reaction [Streptozocin results in increased expression of TIMP2 mRNA]; benazepril inhibits the reaction [Streptozocin results in increased expression of TIMP2 protein] CTD PMID:16732983 PMID:20821936 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
JBrowse link
G Tlr4 toll-like receptor 4 decreases expression ISO benazepril results in decreased expression of TLR4 protein CTD PMID:20981132 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
ISO
EXP
benazepril results in decreased expression of TNF protein
[benazepril co-treated with Amlodipine] results in decreased expression of TNF protein
CTD PMID:16775501 PMID:20981132 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression EXP benazepril results in decreased expression of VCAM1 mRNA; benazepril results in decreased expression of VCAM1 protein CTD PMID:19018797 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP benazepril inhibits the reaction [Streptozocin results in increased expression of VEGFA protein] CTD PMID:20844835 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
bixin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases ubiquitination ISO bixin results in decreased ubiquitination of NFE2L2 protein CTD PMID:30698894 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
cilazapril monohydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme affects response to substance ISO ACE gene polymorphism affects the susceptibility to Cilazapril CTD PMID:15498266 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO Cilazapril results in increased expression of ADIPOQ protein CTD PMID:19789415 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP [Cilazapril co-treated with Losartan] promotes the reaction [Doxorubicin results in increased expression of AGTR1 mRNA]; Cilazapril promotes the reaction [Doxorubicin results in increased expression of AGTR1 mRNA] CTD PMID:15331931 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions EXP [Losartan co-treated with Cilazapril] inhibits the reaction [Doxorubicin results in decreased expression of AGTR2 mRNA]; Cilazapril inhibits the reaction [Doxorubicin results in decreased expression of AGTR2 mRNA] CTD PMID:15331931 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842
JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression EXP Cilazapril results in decreased expression of FGF2 mRNA; Cilazapril results in decreased expression of FGF2 protein CTD PMID:9640960 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Nppa natriuretic peptide A multiple interactions
affects secretion
ISO [Cilazapril co-treated with Verapamil] affects the secretion of NPPA protein
Cilazapril affects the secretion of NPPA protein
CTD PMID:1457087 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Ren renin increases activity EXP Cilazapril results in increased activity of REN protein CTD PMID:2425185 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Slc15a1 solute carrier family 15 member 1 multiple interactions ISO Cilazapril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr15:106,800,081...106,844,668
Ensembl chr15:106,800,081...106,844,426
JBrowse link
G Slc15a2 solute carrier family 15 member 2 multiple interactions EXP Cilazapril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr11:66,932,664...66,961,708
Ensembl chr11:66,932,614...66,961,713
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [Losartan co-treated with Cilazapril] inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; Cilazapril inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein] CTD PMID:15331931 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
crocin-1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO crocin promotes the reaction [pyrazolanthrone inhibits the reaction [TNFSF11 protein results in increased activity of ACP5 protein]] CTD PMID:30580027 NCBI chr 8:23,142,733...23,149,067
Ensembl chr 8:23,142,734...23,148,396
JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions ISO crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of AKT2 mRNA] CTD PMID:30580027 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162
JBrowse link
G Bambi BMP and activin membrane-bound inhibitor multiple interactions EXP crocin inhibits the reaction [Cisplatin results in decreased expression of BAMBI mRNA] CTD PMID:32259551 NCBI chr17:56,905,419...56,909,675
Ensembl chr17:56,905,112...56,909,992
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
EXP
ISO
crocin inhibits the reaction [Diazinon results in increased expression of BAX mRNA]; crocin inhibits the reaction [Diazinon results in increased expression of BAX protein]
crocin results in increased expression of BAX mRNA
CTD PMID:23523949 PMID:27353299 PMID:32886819 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO [crocin co-treated with Paraquat] results in decreased expression of BCL2 mRNA
crocin results in decreased expression of BCL2 mRNA
CTD PMID:31911963 PMID:32886819 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP crocin results in increased expression of BDNF mRNA; crocin results in increased expression of BDNF protein CTD PMID:24401376 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO crocin results in decreased expression of BIRC5 mRNA CTD PMID:32886819 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases cleavage
EXP
ISO
crocin affects the reaction [Ethanol results in increased expression of CASP3 mRNA]; crocin inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP3 protein]; crocin inhibits the reaction [Diazinon results in increased activity of CASP3 protein]; crocin inhibits the reaction [Diazinon results in increased cleavage of CASP3 protein]; crocin inhibits the reaction [Diazinon results in increased expression of CASP3 protein modified form]; crocin inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; crocin inhibits the reaction [Ethanol results in increased activity of CASP3 protein]
crocin results in increased expression of CASP3 mRNA
crocin inhibits the reaction [Paraquat results in increased expression of CASP3 mRNA]
MYCN protein inhibits the reaction [crocin results in increased cleavage of CASP3 protein]
CTD PMID:23523949 PMID:25637687 PMID:25899501 PMID:26807765 PMID:27353299 PMID:30672053 PMID:31911963 PMID:32886819 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity ISO crocin results in increased activity of CASP8 protein CTD PMID:32886819 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
EXP
ISO
crocin inhibits the reaction [Diazinon results in increased cleavage of CASP9 protein]
crocin results in increased activity of CASP9 protein
CTD PMID:27353299 PMID:32886819 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions
decreases activity
increases activity
EXP
ISO
crocin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; crocin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]
crocin results in decreased activity of CAT protein
crocin inhibits the reaction [Patulin results in increased activity of CAT protein]
crocin results in increased activity of CAT protein
CTD PMID:25899501 PMID:26584762 PMID:29409856 PMID:32886819 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO crocin results in decreased expression of CCND1 mRNA CTD PMID:32886819 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ckm creatine kinase, M-type multiple interactions EXP crocin inhibits the reaction [Diazinon results in increased activity of CKM protein] CTD PMID:23523949 NCBI chr 1:80,321,507...80,331,841
Ensembl chr 1:80,321,585...80,331,841
JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Amino Acids]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of phenylpyruvic acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Allantoin]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Amino Acids]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Carnitine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Citric Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatinine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of phenylacetylglycine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uric Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uridine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased secretion of IL1B protein] CTD PMID:24709313 NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP crocin results in increased expression of and results in increased phosphorylation of CREB1 protein CTD PMID:24401376 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP crocin inhibits the reaction [Diazinon affects the localization of CYCS protein] CTD PMID:23523949 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity
EXP crocin inhibits the reaction [Carbon Tetrachloride results in increased activity of CYP2E1 protein]
crocin results in decreased activity of CYP2E1 protein
CTD PMID:25899501 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Glo1 glyoxalase 1 multiple interactions ISO crocin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of GLO1 protein] CTD PMID:30580027 NCBI chr20:9,273,589...9,291,608
Ensembl chr20:9,273,594...9,291,610
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP crocin inhibits the reaction [Cisplatin results in increased activity of GPT protein] CTD PMID:32259551 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like multiple interactions EXP crocin inhibits the reaction [Ethanol results in increased expression of HSPA1L mRNA] CTD PMID:25637687 NCBI chr20:4,879,998...4,965,191
Ensembl chr20:4,959,294...4,964,963
JBrowse link
G Il10 interleukin 10 multiple interactions EXP crocin inhibits the reaction [Doxorubicin results in decreased expression of IL10 protein] CTD PMID:26807765 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased secretion of IL1B protein]; crocin inhibits the reaction [Doxorubicin results in increased expression of IL1B protein] CTD PMID:24709313 PMID:26807765 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
EXP
ISO
crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]; crocin inhibits the reaction [Ethanol results in decreased expression of IL6 protein]; crocin inhibits the reaction [Streptozocin results in increased expression of IL6 protein]
crocin results in decreased expression of IL6 mRNA
CTD PMID:25637687 PMID:25899501 PMID:29409856 PMID:32886819 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO crocin affects the expression of and affects the phosphorylation of JAK2 protein CTD PMID:32886819 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions EXP crocin inhibits the reaction [Diazinon results in decreased expression of LDLR mRNA] CTD PMID:24132704 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
EXP
ISO
crocin inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; crocin inhibits the reaction [Diazinon results in decreased phosphorylation of MAPK1 protein]
crocin results in decreased phosphorylation of MAPK1 protein
CTD PMID:24132704 PMID:28689058 PMID:32886819 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
EXP
ISO
crocin inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK3 protein]; crocin inhibits the reaction [Diazinon results in decreased phosphorylation of MAPK3 protein]
crocin results in decreased phosphorylation of MAPK3 protein
crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of MAPK3 mRNA]
CTD PMID:24132704 PMID:28689058 PMID:30580027 PMID:32886819 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mir122 microRNA 122 multiple interactions EXP crocin inhibits the reaction [bisphenol A results in increased expression of MIR122 mRNA] CTD PMID:28689058 NCBI chr18:60,755,285...60,755,369 JBrowse link
G Mir29b1 microRNA 29b-1 increases expression
multiple interactions
EXP crocin results in increased expression of MIR29B1 mRNA
Cisplatin inhibits the reaction [crocin results in increased expression of MIR29B1 mRNA]; crocin inhibits the reaction [Cisplatin results in decreased expression of MIR29B1 mRNA]
CTD PMID:32259551 NCBI chr 4:58,344,310...58,344,390
Ensembl chr 4:58,344,310...58,344,390
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP crocin inhibits the reaction [Ethanol results in increased activity of MPO protein] CTD PMID:25637687 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO crocin results in decreased expression of MYC mRNA CTD PMID:32886819 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Mycn MYCN proto-oncogene, bHLH transcription factor decreases response to substance
multiple interactions
decreases expression
ISO MYCN results in decreased susceptibility to crocin
crocin results in decreased expression of and results in decreased stability of MYCN mRNA; MYCN protein inhibits the reaction [crocin results in increased cleavage of CASP3 protein]; MYCN protein inhibits the reaction [crocin results in increased cleavage of PARP1 protein]
crocin results in decreased expression of MYCN protein
CTD PMID:30672053 NCBI chr 6:38,222,554...38,228,419
Ensembl chr 6:38,222,555...38,228,379
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions EXP crocin inhibits the reaction [Cisplatin results in increased expression of MYD88 mRNA]; crocin inhibits the reaction [Cisplatin results in increased expression of MYD88 protein] CTD PMID:32259551 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP crocin inhibits the reaction [Cisplatin results in decreased expression of NFE2L2 protein] CTD PMID:32259551 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Ostm1 osteoclastogenesis associated transmembrane protein 1 multiple interactions ISO [crocin co-treated with pyrazolanthrone co-treated with TNFSF11 protein] results in decreased expression of OSTM1 mRNA; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of OSTM1 mRNA] CTD PMID:30580027 NCBI chr20:47,394,979...47,430,304
Ensembl chr20:47,395,014...47,430,284
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO MYCN protein inhibits the reaction [crocin results in increased cleavage of PARP1 protein] CTD PMID:30672053 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO crocin results in decreased expression of PTGS2 mRNA CTD PMID:32886819 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP crocin inhibits the reaction [Streptozocin results in increased expression of RELA protein] CTD PMID:29409856 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Smad2 SMAD family member 2 decreases expression
multiple interactions
EXP crocin results in decreased expression of SMAD2 protein
Cisplatin inhibits the reaction [crocin results in decreased expression of SMAD2 protein]; crocin inhibits the reaction [Cisplatin results in increased expression of SMAD2 protein]
CTD PMID:32259551 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO crocin affects the expression of and affects the phosphorylation of STAT3 protein CTD PMID:32886819 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP crocin inhibits the reaction [Cisplatin results in increased expression of TGFB1 protein]; crocin inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein] CTD PMID:29409856 PMID:32259551 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 multiple interactions EXP crocin inhibits the reaction [Cisplatin results in increased expression of TGFBR1 protein] CTD PMID:32259551 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP crocin inhibits the reaction [Cisplatin results in increased expression of TLR4 mRNA]; crocin inhibits the reaction [Cisplatin results in increased expression of TLR4 protein]; crocin inhibits the reaction [Streptozocin results in increased expression of TLR4 protein] CTD PMID:29409856 PMID:32259551 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
EXP
ISO
crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; crocin inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; crocin inhibits the reaction [Ethanol results in decreased expression of TNF protein]
crocin results in decreased expression of TNF mRNA
CTD PMID:25637687 PMID:25899501 PMID:26807765 PMID:32886819 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO [crocin co-treated with pyrazolanthrone co-treated with TNFSF11 protein] results in decreased expression of OSTM1 mRNA; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of AKT2 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of MAPK3 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of OSTM1 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of TRAF6 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of GLO1 protein]; crocin promotes the reaction [pyrazolanthrone inhibits the reaction [TNFSF11 protein results in increased activity of ACP5 protein]] CTD PMID:30580027 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Tnnt2 troponin T2, cardiac type multiple interactions EXP crocin inhibits the reaction [Doxorubicin results in increased expression of TNNT2 protein] CTD PMID:26807765 NCBI chr13:52,662,974...52,680,992
Ensembl chr13:52,662,996...52,680,990
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO crocin inhibits the reaction [Paraquat results in increased expression of TRP53 mRNA] CTD PMID:31911963 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of TRAF6 mRNA] CTD PMID:30580027 NCBI chr 3:91,252,829...91,271,607
Ensembl chr 3:91,252,829...91,271,607
JBrowse link
G Vgf VGF nerve growth factor inducible increases expression EXP crocin results in increased expression of VGF protein CTD PMID:24401376 NCBI chr12:22,677,302...22,680,630
Ensembl chr12:22,677,607...22,680,630
JBrowse link
enalapril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 increases transport ISO ABCC4 protein results in increased transport of Enalapril CTD PMID:17939016 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Ace angiotensin I converting enzyme decreases activity
multiple interactions
increases expression
ISO
EXP
Enalapril results in decreased activity of ACE protein
Enalapril inhibits the reaction [Dexamethasone results in increased expression of ACE protein]; Enalapril inhibits the reaction [diisononyl phthalate promotes the reaction [Dexamethasone results in increased expression of ACE protein]]
ACE gene polymorphism affects the susceptibility to [Enalapril co-treated with Sodium Chloride]; ACE gene polymorphism inhibits the reaction [[Enalapril co-treated with Sodium Chloride] results in increased susceptibility to AGT protein modified form]
Enalapril inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of ACE protein]; Enalapril promotes the reaction [Folic Acid results in increased expression of ACE mRNA]
Enalapril results in increased expression of ACE mRNA
CTD PMID:15728788 PMID:15816410 PMID:20679179 PMID:20829712 PMID:23733546 PMID:28973481 PMID:30940551 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression EXP Enalapril results in decreased expression of ACTA2 protein CTD PMID:19349682 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Acvrl1 activin A receptor like type 1 decreases expression EXP Enalapril results in decreased expression of ACVRL1 protein CTD PMID:12883979 NCBI chr 7:142,769,942...142,787,336
Ensembl chr 7:142,776,252...142,787,335
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO Enalapril results in increased expression of ADIPOQ protein CTD PMID:25037058 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Adrb1 adrenoceptor beta 1 increases expression EXP Enalapril results in increased expression of ADRB1 protein CTD PMID:7586371 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Agt angiotensinogen decreases activity
affects response to substance
increases expression
decreases response to substance
multiple interactions
decreases expression
EXP
ISO
Enalapril results in decreased activity of AGT protein modified form
AGT gene alternative form affects the susceptibility to Enalapril; AGT protein polymorphism affects the susceptibility to Enalapril
Enalapril results in increased expression of AGT mRNA
Enalapril results in decreased susceptibility to AGT protein modified form
Enalapril affects the reaction [chymostatin results in decreased susceptibility to AGT protein modified form]; Enalapril inhibits the reaction [Cyclosporine results in increased expression of AGT protein]; Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased expression of AGT protein]
Enalapril results in decreased expression of AGT protein modified form
[Enalapril co-treated with Sodium Chloride] results in increased susceptibility to AGT protein modified form; ACE gene polymorphism inhibits the reaction [[Enalapril co-treated with Sodium Chloride] results in increased susceptibility to AGT protein modified form]; Enalapril inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]
Enalapril results in decreased expression of AGT mRNA
CTD PMID:1330361 PMID:2474097 PMID:6319675 PMID:12003776 PMID:12911327 PMID:14659064 PMID:16685205 PMID:18300870 PMID:18679781 PMID:18796534 PMID:19114890 PMID:20829712 PMID:21602471 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Agtr1a angiotensin II receptor, type 1a increases expression
multiple interactions
decreases expression
affects expression
EXP
ISO
Enalapril results in increased expression of AGTR1A mRNA
Enalapril inhibits the reaction [Dexamethasone results in increased expression of AGTR1 protein]; Enalapril inhibits the reaction [diisononyl phthalate promotes the reaction [Dexamethasone results in increased expression of AGTR1 protein]]
Enalapril results in decreased expression of AGTR1A mRNA
Enalapril inhibits the reaction [Cyclosporine results in decreased expression of AGTR1A mRNA]
Enalapril affects the expression of AGTR1A mRNA
CTD PMID:14659064 PMID:18403896 PMID:18765277 PMID:18796534 PMID:30940551 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Agtr2 angiotensin II receptor, type 2 increases expression
decreases expression
EXP Enalapril results in increased expression of AGTR2 mRNA
Enalapril results in decreased expression of AGTR2 mRNA
CTD PMID:9740612 PMID:18403896 PMID:18765277 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Enalapril promotes the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein] CTD PMID:18806606 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions EXP Enalapril inhibits the reaction [Corticosterone results in decreased expression of ALPL mRNA]; Enalapril inhibits the reaction [Ethanol results in decreased expression of ALPL mRNA] CTD PMID:30423288 PMID:31887396 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Ang angiogenin decreases expression ISO Enalapril results in decreased expression of ANG protein CTD PMID:3038326 NCBI chr15:28,022,926...28,028,636 JBrowse link
G Angpt2 angiopoietin 2 multiple interactions EXP Enalapril inhibits the reaction [Streptozocin results in increased expression of ANGPT2 mRNA] CTD PMID:19958114 NCBI chr16:75,966,480...76,016,147
Ensembl chr16:75,966,352...76,016,195
JBrowse link
G Apoe apolipoprotein E multiple interactions ISO [Bezafibrate co-treated with Enalapril co-treated with Dipyridamole co-treated with Atorvastatin co-treated with Valsartan] results in decreased expression of APOE protein
Enalapril inhibits the reaction [APOE gene mutant form results in decreased abundance of Antioxidants]; Enalapril inhibits the reaction [APOE gene mutant form results in increased abundance of Cholesterol]
CTD PMID:19603250 PMID:25037058 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Atf2 activating transcription factor 2 increases expression EXP Enalapril results in increased expression of ATF2 protein CTD PMID:15531746 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 increases expression EXP Enalapril results in increased expression of ATP1A2 mRNA; Enalapril results in increased expression of ATP1A2 protein CTD PMID:18418421 NCBI chr13:90,651,682...90,676,629
Ensembl chr13:90,651,686...90,676,629
JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 decreases expression EXP Enalapril results in decreased expression of ATP1A3 mRNA; Enalapril results in decreased expression of ATP1A3 protein CTD PMID:18418421 NCBI chr 1:81,852,423...81,881,565
Ensembl chr 1:81,852,429...81,881,549
JBrowse link
G Avp arginine vasopressin multiple interactions EXP Enalapril promotes the reaction [Dexamethasone results in increased activity of AVP protein] CTD PMID:3346065 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression EXP Enalapril results in decreased expression of BAX protein CTD PMID:21153712 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions
EXP Enalapril results in increased expression of BCL2 protein
Enalapril inhibits the reaction [Isoproterenol results in decreased expression of BCL2 protein]
CTD PMID:21153712 PMID:30623541 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bdkrb1 bradykinin receptor B1 increases expression
multiple interactions
EXP Enalapril results in increased expression of BDKRB1 mRNA
[kallidin, des-Arg(10)- results in decreased activity of BDKRB1 protein] which results in decreased susceptibility to Enalapril
CTD PMID:18796534 PMID:21430409 NCBI chr 6:129,437,423...129,441,553
Ensembl chr 6:129,438,158...129,440,574
JBrowse link
G Bdkrb2 bradykinin receptor B2 increases expression EXP Enalapril results in increased expression of BDKRB2 mRNA; Enalapril results in increased expression of BDKRB2 protein CTD PMID:18190998 NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676
JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions EXP Enalapril inhibits the reaction [Corticosterone results in decreased expression of BGLAP mRNA]; Enalapril inhibits the reaction [Ethanol results in decreased expression of BGLAP mRNA] CTD PMID:30423288 PMID:31887396 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Enalapril results in decreased activity of CA2 protein CTD PMID:28126276 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Casp3 caspase 3 decreases activity
multiple interactions
EXP Enalapril results in decreased activity of CASP3 protein
Enalapril inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]
CTD PMID:21153712 PMID:30623541 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 decreases activity EXP Enalapril results in decreased activity of CASP9 protein CTD PMID:21153712 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase increases activity
multiple interactions
EXP Enalapril results in increased activity of CAT protein
Enalapril inhibits the reaction [Isoproterenol results in decreased expression of CAT protein]
CTD PMID:12124199 PMID:30623541 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
EXP
ISO
[paricalcitol co-treated with Enalapril] results in decreased expression of CCL2 protein
Enalapril inhibits the reaction [sodium arsenite results in increased secretion of CCL2 protein]
Enalapril results in decreased expression of CCL2 protein
Enalapril results in decreased expression of CCL2 mRNA
CTD PMID:10925121 PMID:17513326 PMID:19627010 PMID:20720404 PMID:25037058 PMID:28973481 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression
multiple interactions
EXP
ISO
Enalapril results in decreased expression of CCN2 mRNA; Enalapril results in decreased expression of CCN2 protein
Enalapril inhibits the reaction [Streptozocin results in increased expression of CCN2 protein]
CTD PMID:18812665 PMID:19349682 PMID:21416479 PMID:25037058 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Cela2a chymotrypsin like elastase 2A decreases expression EXP Enalapril results in decreased expression of CELA2A mRNA CTD PMID:21602471 NCBI chr 5:160,374,031...160,383,782
Ensembl chr 5:160,374,031...160,383,782
JBrowse link
G Cltrn collectrin, amino acid transport regulator decreases expression EXP Enalapril results in decreased expression of CLTRN mRNA; Enalapril results in decreased expression of CLTRN protein CTD PMID:12887829 NCBI chr  X:32,118,082...32,153,687
Ensembl chr  X:32,118,054...32,153,794
JBrowse link
G Clu clusterin decreases expression EXP Enalapril results in decreased expression of CLU protein CTD PMID:12193663 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Cma1 chymase 1 decreases expression EXP Enalapril results in decreased expression of CMA1 mRNA CTD PMID:18796534 NCBI chr15:34,601,037...34,603,819
Ensembl chr15:34,601,037...34,603,819
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Enalapril inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA] CTD PMID:12003776 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression
increases expression
EXP
ISO
Enalapril results in decreased expression of COL3A1 mRNA
Enalapril results in increased expression of COL3A1 mRNA
CTD PMID:17164399 PMID:25037058 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Col4a1 collagen type IV alpha 1 chain multiple interactions
decreases expression
EXP [eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]; [eplerenone co-treated with Enalapril] results in decreased expression of COL4A1 mRNA; [eplerenone co-treated with Enalapril] results in decreased expression of COL4A1 protein; Enalapril inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]; Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of COL4A1 mRNA]
Enalapril results in decreased expression of COL4A1 mRNA; Enalapril results in decreased expression of COL4A1 protein
CTD PMID:9175058 PMID:18682491 NCBI chr16:83,522,162...83,632,153
Ensembl chr16:83,522,162...83,632,153
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions
decreases expression
ISO [paricalcitol co-treated with Enalapril] results in decreased expression of CYBA protein
Enalapril results in decreased expression of CYBA protein
CTD PMID:20720404 PMID:25037058 NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876
JBrowse link
G Cycs cytochrome c, somatic affects localization EXP Enalapril affects the localization of CYCS protein CTD PMID:21153712 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA] CTD PMID:9175058 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Eng endoglin multiple interactions ISO [Enalapril co-treated with paricalcitol] results in decreased expression of ENG mRNA CTD PMID:25037058 NCBI chr 3:11,679,530...11,717,486
Ensembl chr 3:11,679,530...11,717,485
JBrowse link
G Epo erythropoietin decreases expression
multiple interactions
ISO
EXP
Enalapril results in decreased expression of EPO protein
Enalapril inhibits the reaction [Streptozocin results in increased expression of EPO mRNA]
CTD PMID:2474097 PMID:9434678 PMID:19958114 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Epor erythropoietin receptor multiple interactions EXP Enalapril inhibits the reaction [Streptozocin results in increased expression of EPOR mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of EPOR protein] CTD PMID:19958114 NCBI chr 8:22,969,737...22,974,468
Ensembl chr 8:22,969,745...22,974,321
JBrowse link
G F3 coagulation factor III, tissue factor decreases expression
multiple interactions
ISO Enalapril results in decreased expression of F3 protein
Enalapril inhibits the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]
CTD PMID:18060435 PMID:22188725 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Faslg Fas ligand decreases expression EXP Enalapril results in decreased expression of FASLG mRNA CTD PMID:10925121 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Gh1 growth hormone 1 increases response to substance ISO GH1 protein results in increased susceptibility to Enalapril CTD PMID:12883983 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link
G Gja5 gap junction protein, alpha 5 multiple interactions ISO GJA5 affects the reaction [Enalapril results in increased secretion of REN protein] CTD PMID:19109587 NCBI chr 2:199,162,745...199,184,942
Ensembl chr 2:199,162,745...199,184,939
JBrowse link
G Gjc1 gap junction protein, gamma 1 multiple interactions ISO GJC1 affects the reaction [Enalapril results in increased secretion of REN protein] CTD PMID:19109587 NCBI chr10:90,781,408...90,912,440
Ensembl chr10:90,781,402...90,912,287
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP Enalapril inhibits the reaction [Isoproterenol results in decreased phosphorylation of GSK3B protein] CTD PMID:18806606 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Has2 hyaluronan synthase 2 increases expression EXP Enalapril results in increased expression of HAS2 mRNA CTD PMID:20933085 NCBI chr 7:96,438,046...96,464,049
Ensembl chr 7:96,438,046...96,464,049
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP
ISO
Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased expression of HMGB1 protein]
Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of HMGB1 protein]
CTD PMID:19114890 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Enalapril results in increased expression of HMOX1 protein CTD PMID:21263376 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hyal1 hyaluronidase 1 decreases expression EXP Enalapril results in decreased expression of HYAL1 mRNA; Enalapril results in decreased expression of HYAL1 protein CTD PMID:20933085 NCBI chr 8:116,332,834...116,337,522
Ensembl chr 8:116,332,796...116,335,435
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
multiple interactions
EXP
ISO
Enalapril results in decreased expression of ICAM1 protein
Enalapril inhibits the reaction [sodium arsenite results in increased secretion of ICAM1 protein modified form]
[Enalapril co-treated with paricalcitol] results in decreased expression of ICAM1 mRNA
Enalapril results in decreased expression of ICAM1 protein modified form
CTD PMID:14716214 PMID:17347482 PMID:25037058 PMID:28973481 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Igf1 insulin-like growth factor 1 affects expression
decreases expression
EXP Enalapril affects the expression of IGF1 protein
Enalapril results in decreased expression of IGF1 mRNA
CTD PMID:12883983 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression EXP Enalapril results in increased expression of IGFBP1 mRNA CTD PMID:12883983 NCBI chr14:87,448,716...87,453,783
Ensembl chr14:87,448,692...87,453,785
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Enalapril inhibits the reaction [IL1A protein results in increased expression of VEGFA mRNA]; Enalapril inhibits the reaction [IL1A protein results in increased expression of VEGFA protein] CTD PMID:17299153 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
EXP
ISO
Enalapril inhibits the reaction [Acrolein results in increased expression of IL1B mRNA]; Enalapril inhibits the reaction [Acrolein results in increased expression of IL1B protein]; Enalapril inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA]
Enalapril results in decreased expression of IL1B mRNA
CTD PMID:17167242 PMID:21265103 PMID:25037058 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions
affects response to substance
EXP
ISO
Enalapril inhibits the reaction [Acrolein results in increased expression of IL6 mRNA]; Enalapril inhibits the reaction [Acrolein results in increased expression of IL6 protein]; Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased expression of IL6 protein]; Enalapril inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]; Enalapril inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]
Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of IL6 protein]
IL6 gene polymorphism affects the susceptibility to Enalapril
CTD PMID:15342284 PMID:17167242 PMID:19114890 PMID:21265103 PMID:30623541 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO [Atorvastatin co-treated with Enalapril] results in decreased expression of IRAK1 mRNA CTD PMID:20524934 NCBI chr  X:156,716,469...156,726,367
Ensembl chr  X:156,716,604...156,725,977
JBrowse link
G Itga2 integrin subunit alpha 2 decreases expression ISO Enalapril results in decreased expression of ITGA2 mRNA CTD PMID:25037058 NCBI chr 2:46,996,904...47,097,011
Ensembl chr 2:47,000,323...47,096,961
JBrowse link
G Kdr kinase insert domain receptor multiple interactions EXP Enalapril inhibits the reaction [Cyclosporine results in increased expression of KDR mRNA] CTD PMID:12110003 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Kng2 kininogen 2 increases response to substance EXP Enalapril results in increased susceptibility to KNG1 protein modified form CTD PMID:18190998 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Lamb1 laminin subunit beta 1 multiple interactions EXP Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB1 mRNA] CTD PMID:9175058 NCBI chr 6:50,528,796...50,596,593
Ensembl chr 6:50,528,823...50,596,079
JBrowse link
G Lamb2 laminin subunit beta 2 multiple interactions EXP Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB2 mRNA] CTD PMID:9175058 NCBI chr 8:117,268,335...117,280,517
Ensembl chr 8:117,268,337...117,280,517
JBrowse link
G Lep leptin increases response to substance ISO LEP protein results in increased susceptibility to Enalapril CTD PMID:20614101 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases expression
increases phosphorylation
EXP Enalapril results in increased expression of MAPK9 mRNA; Enalapril results in increased expression of MAPK9 protein
Enalapril results in increased phosphorylation of MAPK9 protein
CTD PMID:15531746 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mir146a microRNA 146a multiple interactions ISO [Atorvastatin co-treated with Enalapril] results in decreased expression of MIR146A CTD PMID:20524934 NCBI chr10:28,962,476...28,962,570
Ensembl chr10:28,962,476...28,962,570
JBrowse link
G Mir146b microRNA 146b multiple interactions ISO [Atorvastatin co-treated with Enalapril] results in decreased expression of MIR146B CTD PMID:20524934 NCBI chr 1:266,089,488...266,089,575
Ensembl chr 1:266,089,488...266,089,575
JBrowse link
G Mmp3 matrix metallopeptidase 3 decreases expression ISO Enalapril results in decreased expression of MMP3 mRNA CTD PMID:25037058 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased activity of MPO protein] CTD PMID:19114890 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Myh6 myosin heavy chain 6 multiple interactions EXP Enalapril inhibits the reaction [Streptozocin results in decreased expression of MYH6 mRNA]; Enalapril inhibits the reaction [Streptozocin results in decreased expression of MYH6 protein] CTD PMID:15362513 NCBI chr15:33,605,653...33,629,730
Ensembl chr15:33,605,654...33,629,699
JBrowse link
G Myh7 myosin heavy chain 7 decreases expression
multiple interactions
EXP Enalapril results in decreased expression of MYH7 mRNA
Enalapril inhibits the reaction [Streptozocin results in increased expression of MYH7 mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of MYH7 protein]
CTD PMID:15362513 PMID:21423293 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089
JBrowse link
G Ndst1 N-deacetylase and N-sulfotransferase 1 multiple interactions EXP Enalapril inhibits the reaction [Streptozocin results in decreased expression of NDST1 protein] CTD PMID:15793251 NCBI chr18:55,951,497...56,014,107
Ensembl chr18:55,955,389...55,992,885
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases expression EXP Enalapril results in decreased expression of NFE2L2 mRNA CTD PMID:18765277 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases activity
multiple interactions
EXP Enalapril results in decreased activity of NFKB1 protein
Enalapril inhibits the reaction [Acrolein results in increased expression of NFKB1 mRNA]; Enalapril inhibits the reaction [Acrolein results in increased expression of NFKB1 protein]
CTD PMID:19225048 PMID:21265102 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased degradation of and results in increased phosphorylation of NFKBIA protein] CTD PMID:19114890 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Noa1 nitric oxide associated 1 increases expression
increases activity
EXP Enalapril results in increased expression of NOA1 mRNA
Enalapril results in increased activity of NOA1 protein
CTD PMID:14588141 NCBI chr14:33,107,868...33,124,172
Ensembl chr14:33,108,024...33,124,171
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions
EXP
ISO
Enalapril results in decreased expression of NOS2 protein
[paricalcitol co-treated with Enalapril] results in decreased expression of NOS2 protein
CTD PMID:20720404 PMID:21377515 PMID:25037058 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
increases expression
affects expression
EXP
ISO
[Enalapril co-treated with eplerenone] results in decreased expression of NOS3 mRNA; Enalapril inhibits the reaction [Nitric Oxide deficiency results in decreased expression of NOS3 protein]
Enalapril results in increased expression of NOS3 protein
[paricalcitol co-treated with Enalapril] results in increased expression of NOS3 protein; Enalapril inhibits the reaction [Dexamethasone results in decreased expression of NOS3 protein]; Enalapril inhibits the reaction [diisononyl phthalate promotes the reaction [Dexamethasone results in decreased expression of NOS3 protein]]
Enalapril affects the expression of NOS3 mRNA
CTD PMID:12176110 PMID:16197366 PMID:20571278 PMID:20720404 PMID:25037058 PMID:30940551 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nppa natriuretic peptide A decreases expression ISO
EXP
Enalapril results in decreased expression of NPPA protein
Enalapril results in decreased expression of NPPA mRNA
CTD PMID:2136812 PMID:8112904 PMID:21423293 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP Enalapril inhibits the reaction [Isoproterenol results in increased expression of NPPB protein] CTD PMID:18806606 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 increases expression EXP Enalapril results in increased expression of NR3C2 mRNA CTD PMID:18796534 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link
G Nrf1 nuclear respiratory factor 1 increases expression EXP Enalapril results in increased expression of NRF1 mRNA CTD PMID:18765277 NCBI chr 4:57,335,732...57,445,317
Ensembl chr 4:57,378,069...57,445,341
JBrowse link
G Pdpn podoplanin increases expression EXP Enalapril results in increased expression of PDPN protein CTD PMID:20933085 NCBI chr 5:161,947,137...161,981,441
Ensembl chr 5:161,947,137...161,981,441
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [Enalapril co-treated with Glucose] binds to PPARA protein; Enalapril inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]] CTD PMID:18812576 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression
multiple interactions
EXP Enalapril results in decreased expression of PPARG protein
Enalapril inhibits the reaction [Isoproterenol results in decreased expression of PPARG protein]
CTD PMID:19225048 PMID:30623541 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression EXP Enalapril results in increased expression of PPARGC1A mRNA CTD PMID:18765277 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases expression ISO Enalapril results in increased expression of PRKAA1 protein CTD PMID:25037058 NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404
JBrowse link
G Prkca protein kinase C, alpha decreases expression EXP Enalapril results in decreased expression of PRKCA protein modified form CTD PMID:21565836 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression ISO Enalapril results in decreased expression of PTGS1 mRNA CTD PMID:25037058 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
EXP
ISO
Enalapril results in decreased expression of PTGS2 protein
[paricalcitol co-treated with Enalapril] results in decreased expression of PTGS2 protein
CTD PMID:20720404 PMID:21377515 PMID:25037058 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Pth1r parathyroid hormone 1 receptor multiple interactions EXP Enalapril inhibits the reaction [Folic Acid results in decreased expression of PTH1R protein] CTD PMID:15728788 NCBI chr 8:118,984,531...119,012,803
Ensembl chr 8:118,988,053...119,012,671
JBrowse link
G Pthlh parathyroid hormone-like hormone multiple interactions EXP Enalapril inhibits the reaction [Folic Acid results in increased expression of PTHLH mRNA]; Enalapril inhibits the reaction [Folic Acid results in increased expression of PTHLH protein] CTD PMID:15728788 NCBI chr 4:181,663,425...181,674,181 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Enalapril inhibits the reaction [Isoproterenol results in increased expression of RELA protein] CTD PMID:30623541 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ren renin multiple interactions
increases expression
increases secretion
decreases activity
increases activity
ISO
EXP
[Indomethacin co-treated with Enalapril] results in decreased expression of REN protein; Enalapril inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]
Enalapril results in increased expression of REN mRNA; Enalapril results in increased expression of REN protein
Enalapril results in increased secretion of REN protein
[Sodium Chloride deficiency co-treated with Enalapril] results in increased expression of REN mRNA; GJA5 affects the reaction [Enalapril results in increased secretion of REN protein]; GJC1 affects the reaction [Enalapril results in increased secretion of REN protein]; REN enhancer mutant form results in decreased susceptibility to [Sodium Chloride deficiency co-treated with Enalapril]; Sodium inhibits the reaction [Enalapril results in increased expression of REN mRNA]; Sodium inhibits the reaction [Enalapril results in increased expression of REN protein]; Sodium inhibits the reaction [Enalapril results in increased secretion of REN protein]
Enalapril results in decreased activity of REN protein
Enalapril results in increased activity of REN protein
CTD PMID:1330361 PMID:2994932 PMID:6094050 PMID:11078175 PMID:12434137 PMID:17846348 PMID:18679781 PMID:18796534 PMID:19109587 PMID:19536436 PMID:19767874 PMID:21423293 PMID:21424707 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions EXP Enalapril inhibits the reaction [Corticosterone results in decreased expression of RUNX2 mRNA]; Enalapril inhibits the reaction [Ethanol results in decreased expression of RUNX2 mRNA] CTD PMID:30423288 PMID:31887396 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Sele selectin E multiple interactions ISO Enalapril inhibits the reaction [sodium arsenite results in increased expression of SELE protein] CTD PMID:28973481 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Sell selectin L multiple interactions ISO [Enalapril co-treated with paricalcitol] results in decreased expression of SELL mRNA CTD PMID:25037058 NCBI chr13:82,369,820...82,387,774
Ensembl chr13:82,369,493...82,387,631
JBrowse link
G Selp selectin P multiple interactions
decreases expression
EXP
ISO
Enalapril inhibits the reaction [Diclofenac results in decreased expression of SELP protein]
Enalapril results in decreased expression of SELP mRNA
CTD PMID:14716214 PMID:25037058 NCBI chr13:82,428,914...82,464,629
Ensembl chr13:82,429,063...82,464,628
JBrowse link
G Serpinb2 serpin family B member 2 decreases expression ISO Enalapril results in decreased expression of SERPINB2 mRNA CTD PMID:25037058 NCBI chr13:27,449,907...27,463,015
Ensembl chr13:27,449,934...27,463,010
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions
decreases expression
EXP [eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]; [eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]; [eplerenone co-treated with Enalapril] results in decreased expression of SERPINE1 mRNA; [eplerenone co-treated with Enalapril] results in decreased expression of SERPINE1 protein; Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]; Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]
Enalapril results in decreased expression of SERPINE1 mRNA; Enalapril results in decreased expression of SERPINE1 protein
CTD PMID:18682491 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Slc15a2 solute carrier family 15 member 2 multiple interactions ISO Enalapril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr11:66,932,664...66,961,708
Ensembl chr11:66,932,614...66,961,713
JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions ISO Enalapril inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid] CTD PMID:21272127 NCBI chr 1:221,910,787...221,919,277
Ensembl chr 1:221,910,767...221,919,301
JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions ISO Enalapril inhibits the reaction [SLC22A7 protein results in increased uptake of Glutarates] CTD PMID:12065749 NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions ISO Enalapril inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:15100168 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link
G Smad2 SMAD family member 2 multiple interactions EXP Enalapril promotes the reaction [paricalcitol results in decreased phosphorylation of SMAD2 protein] CTD PMID:17513326 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Smad7 SMAD family member 7 increases expression EXP Enalapril results in increased expression of SMAD7 mRNA; Enalapril results in increased expression of SMAD7 protein CTD PMID:19197123 PMID:19349682 NCBI chr18:71,395,830...71,424,164
Ensembl chr18:71,395,830...71,424,157
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression
ISO [paricalcitol co-treated with Enalapril] results in increased expression of SOD1 protein
Enalapril results in increased expression of SOD1 protein
CTD PMID:20720404 PMID:25037058 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 decreases activity
decreases expression
multiple interactions
EXP
ISO
Enalapril results in decreased activity of SOD2 protein
Enalapril results in decreased expression of SOD2 protein
[paricalcitol co-treated with Enalapril] results in decreased expression of SOD2 protein
CTD PMID:18765277 PMID:20720404 PMID:25037058 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO
EXP
[Enalapril co-treated with paricalcitol] results in decreased expression of SPP1 mRNA
Enalapril inhibits the reaction [Corticosterone results in decreased expression of SPP1 mRNA]; Enalapril inhibits the reaction [Ethanol results in decreased expression of SPP1 mRNA]
CTD PMID:25037058 PMID:30423288 PMID:31887396 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Ssbp1 single stranded DNA binding protein 1 increases expression EXP Enalapril results in increased expression of SSBP1 mRNA CTD PMID:18765277 NCBI chr 4:68,634,844...68,645,112
Ensembl chr 4:68,634,929...68,645,172
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP Enalapril inhibits the reaction [Streptozocin results in increased expression of STAT3 mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of STAT3 protein] CTD PMID:19958114 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tek TEK receptor tyrosine kinase multiple interactions EXP Enalapril inhibits the reaction [Streptozocin results in increased expression of TEK mRNA] CTD PMID:19958114 NCBI chr 5:113,725,717...113,852,799
Ensembl chr 5:113,725,717...113,852,799
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression
EXP [eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; [eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]]; [eplerenone co-treated with Enalapril] results in decreased expression of TGFB1 mRNA; [eplerenone co-treated with Enalapril] results in decreased expression of TGFB1 protein; Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; Enalapril inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]]; Enalapril inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]; Enalapril promotes the reaction [paricalcitol results in decreased expression of TGFB1 mRNA]; Enalapril promotes the reaction [paricalcitol results in decreased expression of TGFB1 protein]
Enalapril results in decreased expression of TGFB1 mRNA; Enalapril results in decreased expression of TGFB1 protein
CTD PMID:12883979 PMID:15309289 PMID:17164399 PMID:17513326 PMID:18682491 PMID:19197123 PMID:19349682 PMID:23733546 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb2 transforming growth factor, beta 2 decreases expression EXP Enalapril results in decreased expression of TGFB2 mRNA CTD PMID:17164399 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Tgfbi transforming growth factor, beta induced decreases secretion
multiple interactions
EXP Enalapril results in decreased secretion of TGFBI protein
[eplerenone co-treated with Enalapril] results in decreased secretion of TGFBI protein
CTD PMID:18682491 NCBI chr17:8,400,123...8,429,338
Ensembl chr17:8,400,146...8,429,338
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 decreases expression EXP Enalapril results in decreased expression of TGFBR1 mRNA; Enalapril results in decreased expression of TGFBR1 protein CTD PMID:12883979 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635
JBrowse link
G Thbs4 thrombospondin 4 increases expression ISO Enalapril results in increased expression of THBS4 mRNA CTD PMID:25037058 NCBI chr 2:22,343,727...22,385,855
Ensembl chr 2:22,343,727...22,385,855
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO [Atorvastatin co-treated with Enalapril] results in decreased expression of TLR4 mRNA; [Atorvastatin co-treated with Enalapril] results in decreased expression of TLR4 protein CTD PMID:20524934 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
EXP
ISO
Enalapril results in decreased expression of TNF protein
Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased expression of TNF protein]; Enalapril inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; Enalapril inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]
[paricalcitol co-treated with Enalapril] results in decreased expression of TNF protein; Enalapril inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of TNF protein]
Enalapril inhibits the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]; Enalapril inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Enalapril inhibits the reaction [TNF protein results in increased expression of VEGFA protein]
CTD PMID:12003776 PMID:16336586 PMID:17167242 PMID:17299153 PMID:18060435 PMID:19114890 PMID:19225048 PMID:20720404 PMID:25037058 PMID:30623541 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tomm20 translocase of outer mitochondrial membrane 20 decreases expression EXP Enalapril results in decreased expression of TOMM20 mRNA CTD PMID:18765277 NCBI chr19:59,863,421...59,873,411
Ensembl chr19:59,863,421...59,873,411
JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO [Atorvastatin co-treated with Enalapril] results in decreased expression of TRAF6 mRNA CTD PMID:20524934 NCBI chr 3:91,252,829...91,271,607
Ensembl chr 3:91,252,829...91,271,607
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 affects expression
decreases expression
ISO Enalapril affects the expression of VCAM1
Enalapril results in decreased expression of VCAM1 mRNA; Enalapril results in decreased expression of VCAM1 protein modified form
CTD PMID:17347482 PMID:19939336 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression
EXP
ISO
Enalapril inhibits the reaction [Cyclosporine results in increased expression of VEGFA protein]
Enalapril inhibits the reaction [IL1A protein results in increased expression of VEGFA mRNA]; Enalapril inhibits the reaction [IL1A protein results in increased expression of VEGFA protein]; Enalapril inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Enalapril inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; Enalapril inhibits the reaction [VEGFA protein results in increased expression of VEGFA mRNA]
Enalapril results in increased expression of VEGFA protein
CTD PMID:12110003 PMID:16202860 PMID:17299153 PMID:21263376 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vwf von Willebrand factor decreases expression ISO Enalapril results in decreased expression of VWF mRNA CTD PMID:25037058 NCBI chr 4:158,085,059...158,219,525
Ensembl chr 4:158,088,505...158,219,523
JBrowse link
fumagillin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP fumagillin inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 mRNA] CTD PMID:15682466 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Metap1 methionyl aminopeptidase 1 decreases activity
multiple interactions
ISO fumagillin results in decreased activity of METAP1 protein
[fumagillin results in decreased activity of [METAP1 protein co-treated with METAP2 protein]] which results in decreased metabolism of YWHAG protein
CTD PMID:14534293 NCBI chr 2:243,744,620...243,777,673
Ensembl chr 2:243,744,620...243,777,673
JBrowse link
G Metap2 methionyl aminopeptidase 2 multiple interactions
decreases activity
EXP
ISO
fumagillin promotes the reaction [Diethylnitrosamine results in increased expression of METAP2 mRNA]
fumagillin results in decreased activity of METAP2 protein
[fumagillin results in decreased activity of [METAP1 protein co-treated with METAP2 protein]] which results in decreased metabolism of YWHAG protein
CTD PMID:14534293 PMID:15516829 PMID:15682466 NCBI chr 7:34,762,241...34,789,456
Ensembl chr 7:34,762,231...34,789,479
JBrowse link
G Tert telomerase reverse transcriptase multiple interactions EXP fumagillin inhibits the reaction [Diethylnitrosamine results in increased activity of TERT protein]; fumagillin inhibits the reaction [Diethylnitrosamine results in increased expression of TERT mRNA] CTD PMID:15682466 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
JBrowse link
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma multiple interactions ISO [fumagillin results in decreased activity of [METAP1 protein co-treated with METAP2 protein]] which results in decreased metabolism of YWHAG protein CTD PMID:14534293 NCBI chr12:23,789,547...23,817,884
Ensembl chr12:23,789,638...23,817,883
JBrowse link
hydrocortisone succinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [hydrocortisone hemisuccinate co-treated with Dimethyl Sulfoxide] results in increased expression of CYP1A2 CTD PMID:18347083 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G F2 coagulation factor II affects expression ISO hydrocortisone hemisuccinate affects the expression of F2 protein CTD PMID:12542493 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G Il18 interleukin 18 decreases secretion ISO hydrocortisone hemisuccinate results in decreased secretion of IL18 protein CTD PMID:20421217 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1b interleukin 1 beta decreases secretion ISO hydrocortisone hemisuccinate results in decreased secretion of IL1B protein CTD PMID:20421217 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 decreases secretion ISO hydrocortisone hemisuccinate results in decreased secretion of IL6 protein CTD PMID:20421217 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Tnf tumor necrosis factor decreases secretion ISO hydrocortisone hemisuccinate results in decreased secretion of TNF protein CTD PMID:20421217 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
imidapril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin I converting enzyme 2 increases response to substance ISO ACE2 gene SNP results in increased susceptibility to imidapril CTD PMID:27121444 NCBI chr  X:32,050,734...32,095,860
Ensembl chr  X:32,049,931...32,096,016
JBrowse link
G Ces1d carboxylesterase 1D multiple interactions ISO CES1 protein results in increased hydrolysis of and results in increased activity of imidapril; CES1 protein results in increased metabolism of and results in increased activity of imidapril; Dust inhibits the reaction [CES1 protein results in increased metabolism of and results in increased activity of imidapril]; tert-butylphenyl diphenyl phosphate inhibits the reaction [CES1 protein results in increased metabolism of and results in increased activity of imidapril]; triphenyl phosphate inhibits the reaction [CES1 protein results in increased metabolism of and results in increased activity of imidapril] CTD PMID:9300133 PMID:31268531 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 affects response to substance ISO CYP11B2 gene polymorphism affects the susceptibility to imidapril CTD PMID:16765146 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
imidaprilat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions ISO imidaprilat inhibits the reaction [AGT protein results in increased activity of and results in increased localization of PRKCA protein] CTD PMID:16257180 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO imidaprilat inhibits the reaction [AGT protein results in increased activity of and results in increased localization of PRKCA protein] CTD PMID:16257180 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
methylprednisolone succinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ces2h carboxylesterase 2H multiple interactions
increases hydrolysis
EXP Dexamethasone promotes the reaction [CES2 protein results in increased hydrolysis of Methylprednisolone Hemisuccinate] CTD PMID:15794950 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
mono(2-ethyl-5-hydroxyhexyl) phthalate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam33 ADAM metallopeptidase domain 33 multiple interactions ISO [[Endocrine Disruptors results in increased abundance of mono(2-ethyl-5-hydroxyhexyl) phthalate] which results in increased methylation of ADAM33 intron] which results in increased expression of ADAM33 mRNA CTD PMID:30226539 NCBI chr 3:123,595,018...123,607,549
Ensembl chr 3:123,595,560...123,607,352
JBrowse link
G Crp C-reactive protein decreases expression ISO mono(2-ethyl-5-hydroxyhexyl) phthalate results in decreased expression of CRP protein CTD PMID:21349512 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions ISO
EXP
[CYP2C19 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-hydroxyhexyl) phthalate
[CYP2C6V1 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-hydroxyhexyl) phthalate
CTD PMID:22186153 PMID:23545481 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP [CYP3A2 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-hydroxyhexyl) phthalate CTD PMID:23545481 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Flg filaggrin multiple interactions ISO [FLG gene polymorphism affects the susceptibility to Diethylhexyl Phthalate] which affects the abundance of mono(2-ethyl-5-hydroxyhexyl) phthalate CTD PMID:24380925 NCBI chr 2:193,565,401...193,574,297 JBrowse link
G Mirlet7c1 microRNA let-7c-1 multiple interactions ISO [Diethylhexyl Phthalate results in increased abundance of mono(2-ethyl-5-hydroxyhexyl) phthalate] which affects the expression of MIRLET7C CTD PMID:30481674 NCBI chr11:16,052,873...16,052,966
Ensembl chr11:16,052,868...16,052,975
JBrowse link
G Shbg sex hormone binding globulin decreases secretion ISO mono(2-ethyl-5-hydroxyhexyl) phthalate results in decreased secretion of SHBG protein CTD PMID:24945889 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
JBrowse link
G Tug1 taurine up-regulated 1 affects expression ISO mono(2-ethyl-5-hydroxyhexyl) phthalate affects the expression of TUG1 mRNA CTD PMID:29385630 NCBI chr14:83,878,757...83,885,791
Ensembl chr14:83,878,295...83,887,584
JBrowse link
mono(2-ethyl-5-oxohexyl) phthalate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam33 ADAM metallopeptidase domain 33 multiple interactions ISO [[Endocrine Disruptors results in increased abundance of mono(2-ethyl-5-oxohexyl)phthalate] which results in increased methylation of ADAM33 intron] which results in increased expression of ADAM33 mRNA CTD PMID:30226539 NCBI chr 3:123,595,018...123,607,549
Ensembl chr 3:123,595,560...123,607,352
JBrowse link
G Crp C-reactive protein decreases expression ISO mono(2-ethyl-5-oxohexyl)phthalate results in decreased expression of CRP protein CTD PMID:21349512 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions ISO
EXP
[CYP2C19 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-oxohexyl)phthalate
[CYP2C6V1 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-oxohexyl)phthalate
CTD PMID:22186153 PMID:23545481 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP [CYP3A2 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-oxohexyl)phthalate CTD PMID:23545481 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Flg filaggrin multiple interactions ISO [FLG gene polymorphism affects the susceptibility to Diethylhexyl Phthalate] which affects the abundance of mono(2-ethyl-5-oxohexyl)phthalate CTD PMID:24380925 NCBI chr 2:193,565,401...193,574,297 JBrowse link
G Mirlet7c1 microRNA let-7c-1 multiple interactions ISO [Diethylhexyl Phthalate results in increased abundance of mono(2-ethyl-5-oxohexyl)phthalate] which affects the expression of MIRLET7C CTD PMID:30481674 NCBI chr11:16,052,873...16,052,966
Ensembl chr11:16,052,868...16,052,975
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases activity ISO mono(2-ethyl-5-oxohexyl)phthalate results in increased activity of PPARA protein CTD PMID:28571686 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO mono(2-ethyl-5-oxohexyl)phthalate binds to and affects the folding of and results in increased activity of PPARG protein CTD PMID:30085373 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Shbg sex hormone binding globulin decreases secretion ISO mono(2-ethyl-5-oxohexyl)phthalate results in decreased secretion of SHBG protein CTD PMID:24945889 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
JBrowse link
mono(2-ethylhexyl) phthalate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca12 ATP binding cassette subfamily A member 12 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ABCA12 mRNA CTD PMID:22401849 NCBI chr 9:78,521,477...78,693,421
Ensembl chr 9:78,522,464...78,693,028
JBrowse link
G Abca4 ATP binding cassette subfamily A member 4 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ABCA4 mRNA CTD PMID:22401849 NCBI chr 2:225,645,539...225,783,288
Ensembl chr 2:225,645,568...225,783,287
JBrowse link
G Abca7 ATP binding cassette subfamily A member 7 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ABCA7 mRNA CTD PMID:22401849 NCBI chr 7:12,742,433...12,762,423
Ensembl chr 7:12,742,433...12,762,341
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ABCB1B mRNA CTD PMID:22401849 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb9 ATP binding cassette subfamily B member 9 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ABCB9 mRNA CTD PMID:22401849 NCBI chr12:37,923,974...37,956,678
Ensembl chr12:37,923,528...37,958,363
JBrowse link
G Abcc10 ATP binding cassette subfamily C member 10 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ABCC10 mRNA CTD PMID:22401849 NCBI chr 9:17,041,351...17,061,263
Ensembl chr 9:17,041,389...17,063,780
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of ABCC2 mRNA CTD PMID:22401849 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ABCC6 mRNA CTD PMID:22401849 NCBI chr 1:101,954,786...102,013,252
Ensembl chr 1:101,959,540...102,013,243
JBrowse link
G Acaa1b acetyl-Coenzyme A acyltransferase 1B increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ACAA1B mRNA CTD PMID:32522588 NCBI chr 8:127,836,235...127,845,296 JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ACAA2 mRNA CTD PMID:32522588 NCBI chr18:70,733,872...70,762,395
Ensembl chr18:70,733,872...70,762,395
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ACADM mRNA CTD PMID:32522588 NCBI chr 2:260,124,418...260,148,589
Ensembl chr 2:260,124,418...260,148,589
JBrowse link
G Acads acyl-CoA dehydrogenase short chain increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of ACADS mRNA CTD PMID:22087261 NCBI chr12:47,254,503...47,263,747
Ensembl chr12:47,254,484...47,263,747
JBrowse link
G Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ACAP1 mRNA CTD PMID:22401849 NCBI chr10:56,492,300...56,506,446
Ensembl chr10:56,492,300...56,506,446
JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression EXP
ISO
mono-(2-ethylhexyl)phthalate results in increased expression of ACOX1 mRNA CTD PMID:22087261 PMID:32522588 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Acoxl acyl-CoA oxidase-like decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ACOXL mRNA CTD PMID:22401849 NCBI chr 3:120,414,311...120,724,809
Ensembl chr 3:120,414,291...120,726,336
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ACSL1 protein CTD PMID:27384973 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246
JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ACSL4 mRNA CTD PMID:22401849 NCBI chr  X:113,596,247...113,660,024
Ensembl chr  X:113,596,239...113,659,944
JBrowse link
G Adam22 ADAM metallopeptidase domain 22 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ADAM22 mRNA CTD PMID:22401849 NCBI chr 4:22,864,485...23,002,969
Ensembl chr 4:22,859,622...22,996,645
JBrowse link
G Adam23 ADAM metallopeptidase domain 23 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ADAM23 mRNA CTD PMID:22401849 NCBI chr 9:70,133,969...70,293,312
Ensembl chr 9:70,133,969...70,290,117
JBrowse link
G Adamts20 ADAM metallopeptidase with thrombospondin type 1 motif, 20 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ADAMTS20 mRNA CTD PMID:22401849 NCBI chr 7:135,465,021...135,630,941
Ensembl chr 7:135,466,884...135,630,654
JBrowse link
G Adamts4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ADAMTS4 mRNA CTD PMID:22401849 NCBI chr13:89,622,996...89,632,485
Ensembl chr13:89,622,632...89,634,419
JBrowse link
G Adarb2 adenosine deaminase, RNA-specific, B2 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ADARB2 mRNA CTD PMID:22401849 NCBI chr17:58,098,979...58,653,137
Ensembl chr17:58,104,559...58,301,260
JBrowse link
G Adcy4 adenylate cyclase 4 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ADCY4 mRNA CTD PMID:22401849 NCBI chr15:34,453,917...34,469,779
Ensembl chr15:34,453,915...34,469,746
JBrowse link
G Adcy7 adenylate cyclase 7 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ADCY7 mRNA CTD PMID:22401849 NCBI chr19:19,702,307...19,762,973
Ensembl chr19:19,704,859...19,727,081
JBrowse link
G Adgre4 adhesion G protein-coupled receptor E4 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ADGRE4 mRNA CTD PMID:22401849 NCBI chr 9:8,056,034...8,200,262
Ensembl chr 9:8,052,210...8,198,800
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ADIPOQ protein CTD PMID:27384973 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Adipor2 adiponectin receptor 2 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ADIPOR2 mRNA CTD PMID:32522588 NCBI chr 4:151,412,135...151,480,108
Ensembl chr 4:151,414,684...151,428,894
JBrowse link
G Adora1 adenosine A1 receptor decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ADORA1 mRNA CTD PMID:22401849 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
JBrowse link
G Adra1d adrenoceptor alpha 1D decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ADRA1D mRNA CTD PMID:22401849 NCBI chr 3:124,129,558...124,145,566
Ensembl chr 3:124,129,558...124,145,566
JBrowse link
G Afm afamin increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of AFM mRNA CTD PMID:22401849 NCBI chr14:19,078,678...19,132,212
Ensembl chr14:19,078,680...19,132,208
JBrowse link
G Agbl3 AGBL carboxypeptidase 3 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of AGBL3 mRNA CTD PMID:22401849 NCBI chr 4:62,293,158...62,377,740
Ensembl chr 4:62,299,044...62,376,533
JBrowse link
G Agl amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase multiple interactions EXP mono-(2-ethylhexyl)phthalate binds to and affects the activity of AGL protein CTD PMID:19240039 NCBI chr 2:219,788,234...219,843,189
Ensembl chr 2:219,788,234...219,842,986
JBrowse link
G Agtr1b angiotensin II receptor, type 1b decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of AGTR1B mRNA CTD PMID:22401849 NCBI chr 2:105,149,020...105,224,335
Ensembl chr 2:105,149,020...105,224,295
JBrowse link
G Ahcy adenosylhomocysteinase decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of AHCY mRNA CTD PMID:22401849 NCBI chr 3:150,587,833...150,603,057
Ensembl chr 3:150,587,833...150,603,082
JBrowse link
G Ahr aryl hydrocarbon receptor increases expression
multiple interactions
affects expression
EXP
ISO
mono-(2-ethylhexyl)phthalate results in increased expression of AHR mRNA
[monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] affects the expression of AHR mRNA
mono-(2-ethylhexyl)phthalate affects the expression of AHR mRNA
CTD PMID:12706301 PMID:28381288 PMID:31884101 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor multiple interactions ISO [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] affects the expression of AHRR mRNA CTD PMID:31884101 NCBI chr 1:31,603,297...31,698,329
Ensembl chr 1:31,603,297...31,698,329
JBrowse link
G Ahsg alpha-2-HS-glycoprotein increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of AHSG protein CTD PMID:27384973 NCBI chr11:81,711,269...81,717,594 JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression
multiple interactions
ISO mono-(2-ethylhexyl)phthalate results in increased expression of AIFM1 mRNA
[monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in increased expression of AIFM1 mRNA; Estradiol affects the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of AIFM1 mRNA]
CTD PMID:24412242 PMID:31884101 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Aifm3 apoptosis inducing factor, mitochondria associated 3 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of AIFM3 mRNA CTD PMID:22401849 NCBI chr11:87,364,452...87,380,705
Ensembl chr11:87,366,621...87,380,704
JBrowse link
G Ajuba ajuba LIM protein increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of AJUBA mRNA CTD PMID:16809437 NCBI chr15:33,208,210...33,218,456
Ensembl chr15:33,208,216...33,218,456
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
increases activity
affects response to substance
ISO
EXP
AKT1 protein affects the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of BCL2L1 mRNA]; AKT1 protein affects the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of BCL2L1 protein]; AKT1 protein affects the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of NFKB1 mRNA]; mono-(2-ethylhexyl)phthalate inhibits the reaction [INS protein results in increased expression of and results in increased phosphorylation of AKT1 protein]
mono-(2-ethylhexyl)phthalate inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]
mono-(2-ethylhexyl)phthalate results in increased phosphorylation of AKT1 protein
mono-(2-ethylhexyl)phthalate results in increased activity of AKT1 protein
AKT1 protein affects the susceptibility to mono-(2-ethylhexyl)phthalate
CTD PMID:18755736 PMID:28526321 PMID:31009676 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Akt1s1 AKT1 substrate 1 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of AKT1S1 mRNA CTD PMID:22401849 NCBI chr 1:100,845,443...100,851,961
Ensembl chr 1:100,845,563...100,851,960
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated decreases expression ISO mono-(2-ethylhexyl)phthalate analog results in decreased expression of ALPL protein; mono-(2-ethylhexyl)phthalate results in decreased expression of ALPL protein CTD PMID:25777084 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Amh anti-Mullerian hormone decreases expression ISO
EXP
mono-(2-ethylhexyl)phthalate results in decreased expression of AMH mRNA
mono-(2-ethylhexyl)phthalate results in decreased expression of AMH protein
CTD PMID:19165384 PMID:19440488 NCBI chr 7:11,775,155...11,777,503
Ensembl chr 7:11,775,155...11,777,503
JBrowse link
G Ank1 ankyrin 1 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ANK1 mRNA CTD PMID:22401849 NCBI chr16:73,681,422...73,912,605
Ensembl chr16:73,681,422...73,827,488
JBrowse link
G Ano9 anoctamin 9 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ANO9 mRNA CTD PMID:22401849 NCBI chr 1:213,908,389...213,929,291
Ensembl chr 1:213,908,982...213,921,208
JBrowse link
G Antxr2 ANTXR cell adhesion molecule 2 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ANTXR2 mRNA CTD PMID:22401849 NCBI chr14:13,191,716...13,331,286
Ensembl chr14:13,192,347...13,274,978
JBrowse link
G Aox1 aldehyde oxidase 1 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of AOX1 mRNA CTD PMID:23360888 NCBI chr 9:64,929,682...65,007,872
Ensembl chr 9:64,929,721...65,007,870
JBrowse link
G Apln apelin affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of APLN mRNA CTD PMID:32522588 NCBI chr  X:134,856,719...134,866,210
Ensembl chr  X:134,856,726...134,866,210
JBrowse link
G Apoe apolipoprotein E increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of APOE mRNA CTD PMID:22087261 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Ar androgen receptor multiple interactions ISO mono-(2-ethylhexyl)phthalate inhibits the reaction [cyclopamine results in increased expression of AR]
[monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of AR mRNA
CTD PMID:26710974 PMID:31884101 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] affects the expression of ARNT mRNA CTD PMID:31884101 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Arrb2 arrestin, beta 2 multiple interactions EXP mono-(2-ethylhexyl)phthalate inhibits the reaction [INS1 protein results in increased expression of ARRB2 protein] CTD PMID:28526321 NCBI chr10:57,040,252...57,048,045
Ensembl chr10:57,040,267...57,048,134
JBrowse link
G Arrdc3 arrestin domain containing 3 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ARRDC3 mRNA CTD PMID:24356939 NCBI chr 2:8,732,907...8,745,445
Ensembl chr 2:8,732,932...8,743,069
JBrowse link
G Artn artemin increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ARTN mRNA CTD PMID:22401849 NCBI chr 5:136,759,717...136,765,036
Ensembl chr 5:136,759,717...136,762,986
JBrowse link
G Ascc3 activating signal cointegrator 1 complex subunit 3 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ASCC3 mRNA CTD PMID:22401849 NCBI chr20:55,253,670...55,557,249
Ensembl chr20:55,253,686...55,556,473
JBrowse link
G Atf3 activating transcription factor 3 increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of ATF3 mRNA CTD PMID:16809437 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atf7ip2 activating transcription factor 7 interacting protein 2 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ATF7IP2 mRNA CTD PMID:22401849 NCBI chr10:5,476,205...5,519,893
Ensembl chr10:5,476,966...5,511,955
JBrowse link
G Atp12a ATPase H+/K+ transporting non-gastric alpha2 subunit decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ATP12A mRNA CTD PMID:22401849 NCBI chr15:36,561,306...36,590,171
Ensembl chr15:36,565,495...36,590,171
JBrowse link
G Atp13a4 ATPase 13A4 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ATP13A4 mRNA CTD PMID:22401849 NCBI chr11:74,833,824...74,968,160
Ensembl chr11:74,834,050...74,968,336
JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ATP1A3 mRNA CTD PMID:22401849 NCBI chr 1:81,852,423...81,881,565
Ensembl chr 1:81,852,429...81,881,549
JBrowse link
G Atp6v1c2 ATPase H+ transporting V1 subunit C2 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ATP6V1C2 mRNA CTD PMID:22401849 NCBI chr 6:42,585,452...42,632,289
Ensembl chr 6:42,585,934...42,630,983
JBrowse link
G Atp6v1h ATPase H+ transporting V1 subunit H affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of ATP6V1H mRNA CTD PMID:21195148 NCBI chr 5:14,262,352...14,367,898
Ensembl chr 5:14,262,349...14,367,898
JBrowse link
G Atp8b4 ATPase phospholipid transporting 8B4 (putative) decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ATP8B4 mRNA CTD PMID:22401849 NCBI chr 3:118,591,560...118,968,210
Ensembl chr 3:118,591,880...118,959,850
JBrowse link
G Atp9b ATPase phospholipid transporting 9B (putative) increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ATP9B mRNA CTD PMID:22401849 NCBI chr18:77,343,551...77,535,608
Ensembl chr18:77,343,551...77,535,593
JBrowse link
G Atrnl1 attractin like 1 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ATRNL1 mRNA CTD PMID:22401849 NCBI chr 1:278,546,113...279,098,977
Ensembl chr 1:278,557,792...278,815,473
JBrowse link
G Avpi1 arginine vasopressin-induced 1 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of AVPI1 mRNA CTD PMID:22401849 NCBI chr 1:261,365,590...261,371,519
Ensembl chr 1:261,365,590...261,371,508
JBrowse link
G B3galt1 Beta-1,3-galactosyltransferase 1 increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of B3GALT1 mRNA CTD PMID:16809437 NCBI chr 3:53,699,409...54,269,612
Ensembl chr 3:54,253,949...54,267,292
JBrowse link
G B3galt2 Beta-1,3-galactosyltransferase 2 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of B3GALT2 mRNA CTD PMID:22401849 NCBI chr13:60,435,946...60,444,957
Ensembl chr13:60,435,946...60,444,957
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO mono-(2-ethylhexyl)phthalate results in increased expression of BAX mRNA; mono-(2-ethylhexyl)phthalate results in increased expression of BAX protein
[monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in increased expression of BAX mRNA
CTD PMID:12927354 PMID:24706461 PMID:26597031 PMID:31884101 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Baz1a bromodomain adjacent to zinc finger domain, 1A decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of BAZ1A mRNA CTD PMID:22401849 NCBI chr 6:75,793,223...75,873,854
Ensembl chr 6:75,793,960...75,874,235
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of BBC3 protein CTD PMID:24706461 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO mono-(2-ethylhexyl)phthalate results in decreased expression of BCL2 mRNA; mono-(2-ethylhexyl)phthalate results in decreased expression of BCL2 protein
MIR16-1 mRNA affects the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of BCL2 protein]
[mono-(2-ethylhexyl)phthalate co-treated with Estradiol] results in decreased expression of BCL2 mRNA; [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] affects the expression of BCL2 mRNA
CTD PMID:12927354 PMID:24412242 PMID:24706461 PMID:26597031 PMID:31884101 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
increases expression
ISO AKT1 protein affects the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of BCL2L1 mRNA]; AKT1 protein affects the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of BCL2L1 protein]
mono-(2-ethylhexyl)phthalate results in increased expression of BCL2L1 mRNA; mono-(2-ethylhexyl)phthalate results in increased expression of BCL2L1 protein
CTD PMID:18755736 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bcl2l10 BCL2 like 10 multiple interactions
decreases expression
ISO [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of BCL2L10 mRNA; Estradiol affects the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of BCL2L10 mRNA] CTD PMID:24412242 PMID:31884101 NCBI chr 8:82,288,705...82,294,750
Ensembl chr 8:82,288,705...82,294,744
JBrowse link
G Bcl6 BCL6, transcription repressor increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of BCL6 mRNA CTD PMID:16809437 NCBI chr11:80,255,790...80,279,075
Ensembl chr11:80,255,790...80,279,075
JBrowse link
G Bean1 brain expressed, associated with NEDD4, 1 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of BEAN1 mRNA CTD PMID:22401849 NCBI chr19:947,862...993,467
Ensembl chr19:949,607...983,556
JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of BHMT mRNA CTD PMID:22401849 NCBI chr 2:23,236,573...23,256,158
Ensembl chr 2:23,236,575...23,256,158
JBrowse link
G Bicra BRD4 interacting chromatin remodeling complex associated protein decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of BICRA mRNA CTD PMID:22401849 NCBI chr 1:77,869,020...77,943,828
Ensembl chr 1:77,869,020...77,893,509
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in increased expression of BID mRNA CTD PMID:31884101 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Bok BCL2 family apoptosis regulator BOK decreases expression
multiple interactions
ISO mono-(2-ethylhexyl)phthalate results in decreased expression of BOK mRNA
[monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of BOK mRNA
CTD PMID:24412242 PMID:31884101 NCBI chr 9:100,829,593...100,840,498
Ensembl chr 9:100,829,552...100,840,504
JBrowse link
G Bpifb6 BPI fold containing family B, member 6 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of BPIFB6 mRNA CTD PMID:22401849 NCBI chr 3:149,382,312...149,396,130
Ensembl chr 3:149,391,929...149,396,130
JBrowse link
G Brd3 bromodomain containing 3 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of BRD3 mRNA CTD PMID:22401849 NCBI chr 3:5,995,204...6,054,467
Ensembl chr 3:5,997,315...6,054,483
JBrowse link
G Brsk1 BR serine/threonine kinase 1 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of BRSK1 mRNA CTD PMID:22401849 NCBI chr 1:72,701,281...72,727,061
Ensembl chr 1:72,701,610...72,727,112
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of BTG2 mRNA CTD PMID:16809437 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982
JBrowse link
G Bves blood vessel epicardial substance decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of BVES mRNA CTD PMID:22401849 NCBI chr20:50,439,885...50,474,678
Ensembl chr20:50,439,883...50,474,678
JBrowse link
G C1qtnf6 C1q and TNF related 6 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of C1QTNF6 mRNA CTD PMID:22401849 NCBI chr 7:119,746,150...119,752,727
Ensembl chr 7:119,746,118...119,753,290
JBrowse link
G C8a complement C8 alpha chain increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of C8A mRNA CTD PMID:22401849 NCBI chr 5:124,348,536...124,403,117
Ensembl chr 5:124,348,461...124,403,195
JBrowse link
G Cabp1 calcium binding protein 1 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of CABP1 mRNA CTD PMID:22401849 NCBI chr12:47,185,449...47,209,785
Ensembl chr12:47,179,664...47,209,784
JBrowse link
G Cadm1 cell adhesion molecule 1 affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of CADM1 mRNA CTD PMID:21195148 NCBI chr 8:51,858,906...52,200,591
Ensembl chr 8:52,127,399...52,189,722
JBrowse link
G Camk1d calcium/calmodulin-dependent protein kinase ID increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of CAMK1D mRNA CTD PMID:22401849 NCBI chr17:76,532,611...76,938,956
Ensembl chr17:76,532,611...76,938,956
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
increases expression
ISO
EXP
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [PPARG protein promotes the reaction [mono-(2-ethylhexyl)phthalate results in increased activity of CASP3 protein]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [PPARG protein promotes the reaction [mono-(2-ethylhexyl)phthalate results in increased activity of CASP3 protein]]; PPARG protein promotes the reaction [mono-(2-ethylhexyl)phthalate results in increased activity of CASP3 protein]; rosiglitazone promotes the reaction [PPARG protein promotes the reaction [mono-(2-ethylhexyl)phthalate results in increased activity of CASP3 protein]]
[monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CASP3 mRNA
mono-(2-ethylhexyl)phthalate results in increased cleavage of CASP3 protein
mono-(2-ethylhexyl)phthalate results in increased expression of CASP3 protein
CTD PMID:12927354 PMID:19165384 PMID:19720108 PMID:23360888 PMID:24706461 PMID:30476341 PMID:31884101 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases activity ISO mono-(2-ethylhexyl)phthalate results in increased activity of CASP7 protein CTD PMID:23360888 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CASP8 mRNA CTD PMID:31884101 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity ISO mono-(2-ethylhexyl)phthalate results in increased activity of CASP9 protein CTD PMID:24706461 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions
increases activity
increases expression
EXP
ISO
Cycloheximide inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of CAT protein]
mono-(2-ethylhexyl)phthalate results in increased activity of CAT protein
[monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in increased expression of CAT mRNA
CTD PMID:2306265 PMID:6845354 PMID:31884101 PMID:32522588 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cbs cystathionine beta synthase affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of CBS mRNA CTD PMID:21195148 NCBI chr20:10,361,987...10,386,663
Ensembl chr20:10,361,988...10,386,751
JBrowse link
G Ccdc27 coiled-coil domain containing 27 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of CCDC27 mRNA CTD PMID:22401849 NCBI chr 5:171,312,790...171,327,581
Ensembl chr 5:171,312,793...171,327,450
JBrowse link
G Ccdc96 coiled-coil domain containing 96 affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of CCDC96 mRNA CTD PMID:21195148 NCBI chr14:79,443,151...79,445,591
Ensembl chr14:79,443,543...79,445,471
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of CCL2 mRNA CTD PMID:27384973 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccn1 cellular communication network factor 1 increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of CCN1 mRNA CTD PMID:16809437 NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of CCN2 mRNA CTD PMID:16809437 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ccna2 cyclin A2 multiple interactions ISO [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CCNA2 mRNA CTD PMID:31884101 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CCNB1 mRNA CTD PMID:31884101 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnb2 cyclin B2 multiple interactions ISO [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CCNB2 mRNA CTD PMID:31884101 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Ccnd1 cyclin D1 affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of CCND1 mRNA CTD PMID:21195148 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd2 cyclin D2 multiple interactions
decreases expression
ISO Estradiol inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of CCND2 mRNA] CTD PMID:19874833 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Ccnd3 cyclin D3 multiple interactions ISO [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CCND3 mRNA CTD PMID:31884101 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CCNE1 mRNA CTD PMID:31884101 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Ccno cyclin O affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of CCNO mRNA CTD PMID:21195148 NCBI chr 2:44,857,043...44,860,317
Ensembl chr 2:44,857,213...44,860,315
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 multiple interactions ISO [bisphenol A co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-benzyl phthalate co-treated with monobutyl phthalate] results in increased expression of CCR7 mRNA CTD PMID:30398665 NCBI chr10:87,057,335...87,067,444
Ensembl chr10:87,057,136...87,067,456
JBrowse link
G Ccrl2 C-C motif chemokine receptor like 2 increases expression
decreases expression
EXP
ISO
mono-(2-ethylhexyl)phthalate results in increased expression of CCRL2 mRNA
mono-(2-ethylhexyl)phthalate results in decreased expression of CCRL2 mRNA
CTD PMID:16809437 PMID:22401849 NCBI chr 8:119,324,298...119,326,954
Ensembl chr 8:119,324,613...119,326,938
JBrowse link
G Cd109 CD109 molecule affects expression
decreases expression
ISO mono-(2-ethylhexyl)phthalate affects the expression of CD109 mRNA
mono-(2-ethylhexyl)phthalate results in decreased expression of CD109 mRNA
CTD PMID:21195148 PMID:22401849 NCBI chr 8:85,951,420...86,065,411
Ensembl chr 8:85,951,191...86,065,409
JBrowse link
G Cd163 CD163 molecule increases expression
multiple interactions
ISO mono-(2-ethylhexyl)phthalate results in increased expression of CD163 protein
[bisphenol A co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-benzyl phthalate co-treated with monobutyl phthalate] results in decreased expression of CD163 mRNA
mono-(2-ethylhexyl)phthalate inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CD163 mRNA]
CTD PMID:22143055 PMID:29718165 PMID:30398665 NCBI chr 4:156,752,063...156,785,467
Ensembl chr 4:156,752,082...156,785,467
JBrowse link
G Cd24 CD24 molecule affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of CD24A mRNA CTD PMID:21195148 NCBI chr20:48,335,540...48,340,847
Ensembl chr20:48,335,540...48,340,846
JBrowse link
G Cd36 CD36 molecule multiple interactions ISO mono-(2-ethylhexyl)phthalate inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CD36 mRNA] CTD PMID:29718165 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cd40 CD40 molecule affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of CD40 mRNA CTD PMID:21195148 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cd69 Cd69 molecule increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of CD69 mRNA CTD PMID:16809437 NCBI chr 4:163,041,147...163,049,065
Ensembl chr 4:163,041,141...163,049,084
JBrowse link
G Cdh2 cadherin 2 multiple interactions EXP [Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [mono-(2-ethylhexyl)phthalate affects the localization of CDH2 protein]; mono-(2-ethylhexyl)phthalate results in increased expression of and affects the localization of CDH2 protein CTD PMID:29940330 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Cdh23 cadherin-related 23 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of CDH23 mRNA CTD PMID:22401849 NCBI chr20:29,857,018...30,263,758
Ensembl chr20:29,857,637...29,990,111
JBrowse link
G Cdhr2 cadherin-related family member 2 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of CDHR2 mRNA CTD PMID:22401849 NCBI chr17:10,415,044...10,450,589
Ensembl chr17:10,415,123...10,439,691
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CDK2 mRNA CTD PMID:31884101 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression
multiple interactions
ISO mono-(2-ethylhexyl)phthalate results in decreased expression of CDK4 mRNA
[monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CDK4 mRNA; Estradiol inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of CDK4 mRNA]
CTD PMID:19874833 PMID:31884101 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
multiple interactions
increases activity
ISO mono-(2-ethylhexyl)phthalate results in decreased expression of CDKN1A mRNA
[monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in increased expression of CDKN1A mRNA
Selenomethionine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased activity of CDKN1A protein]; Sodium Selenite inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased activity of CDKN1A protein]
CTD PMID:21515331 PMID:22401849 PMID:31884101 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CDKN1B mRNA CTD PMID:31884101 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C multiple interactions ISO [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CDKN1C mRNA CTD PMID:31884101 NCBI chr 1:216,661,067...216,663,791
Ensembl chr 1:216,661,080...216,663,721
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions ISO [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in increased expression of CDKN2A mRNA CTD PMID:31884101 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B multiple interactions ISO [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in increased expression of CDKN2B mRNA CTD PMID:31884101 NCBI chr 5:107,834,353...107,857,428
Ensembl chr 5:107,845,951...107,858,104
JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C multiple interactions ISO [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CDKN2C mRNA CTD PMID:31884101 NCBI chr 5:129,347,731...129,352,886
Ensembl chr 5:129,347,732...129,352,886
JBrowse link
G Cdkn2d cyclin dependent kinase inhibitor 2D multiple interactions ISO [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] affects the expression of CDKN2D mRNA CTD PMID:31884101
G Cdo1 cysteine dioxygenase type 1 increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of CDO1 mRNA CTD PMID:16809437 NCBI chr18:40,702,027...40,716,901
Ensembl chr18:40,701,984...40,716,686
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression
increases expression
multiple interactions
ISO
EXP
mono-(2-ethylhexyl)phthalate results in decreased expression of CEBPA protein
mono-(2-ethylhexyl)phthalate results in increased expression of CEBPA mRNA
Colforsin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of CEBPA protein]
CTD PMID:21832167 PMID:25543134 PMID:27384973 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of CEBPB mRNA CTD PMID:25543134 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Celsr2 cadherin, EGF LAG seven-pass G-type receptor 2 multiple interactions
increases phosphorylation
affects transport
ISO [IC 261 results in decreased activity of CSNK1A1 protein] inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased phosphorylation of CELSR2 protein]
mono-(2-ethylhexyl)phthalate affects the transport of CELSR2 protein
CTD PMID:16484285 NCBI chr 2:211,183,410...211,207,458
Ensembl chr 2:211,183,311...211,207,465
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions ISO [FASL affects the susceptibility to mono-(2-ethylhexyl)phthalate] which affects the expression of CFLAR protein CTD PMID:20100735 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Cga glycoprotein hormones, alpha polypeptide multiple interactions
affects expression
increases expression
increases secretion
ISO mono-(2-ethylhexyl)phthalate inhibits the reaction [CGA protein results in increased abundance of Estradiol]
mono-(2-ethylhexyl)phthalate affects the expression of CGA mRNA
mono-(2-ethylhexyl)phthalate results in increased expression of CGA mRNA
mono-(2-ethylhexyl)phthalate results in increased secretion of CGA protein
mono-(2-ethylhexyl)phthalate inhibits the reaction [CGA protein results in increased abundance of Progesterone]
CTD PMID:19501113 PMID:27181934 PMID:28381288 PMID:29089286 NCBI chr 5:50,362,491...50,393,368
Ensembl chr 5:50,381,244...50,393,367
JBrowse link
G Chat choline O-acetyltransferase increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of CHAT mRNA CTD PMID:21145954 NCBI chr16:8,576,858...8,686,131
Ensembl chr16:8,577,840...8,686,131
JBrowse link
G Chd5 chromodomain helicase DNA binding protein 5 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of CHD5 mRNA CTD PMID:22401849 NCBI chr 5:169,519,212...169,572,059
Ensembl chr 5:169,519,212...169,567,107
JBrowse link
G Chrd chordin affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of CHRD mRNA CTD PMID:21195148 NCBI chr11:83,858,503...83,867,543
Ensembl chr11:83,858,503...83,867,203
JBrowse link
G Chrna9 cholinergic receptor nicotinic alpha 9 subunit affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of CHRNA9 mRNA CTD PMID:21195148 NCBI chr14:43,883,450...43,890,171
Ensembl chr14:43,883,458...43,890,171
JBrowse link
G Cidea cell death-inducing DFFA-like effector a increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of CIDEA mRNA CTD PMID:32522588 NCBI chr18:63,082,861...63,108,450
Ensembl chr18:63,098,144...63,108,051
JBrowse link
G Clasp2 cytoplasmic linker associated protein 2 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of CLASP2 mRNA CTD PMID:22401849 NCBI chr 8:122,003,719...122,185,495
Ensembl chr 8:122,003,916...122,185,495
JBrowse link
G Cldn18 claudin 18 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of CLDN18 mRNA CTD PMID:22401849 NCBI chr 8:107,933,725...107,960,656
Ensembl chr 8:107,934,860...107,952,530
JBrowse link
G Cldn6 claudin 6 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of CLDN6 mRNA CTD PMID:22321834 NCBI chr10:12,999,256...13,002,860
Ensembl chr10:13,000,090...13,002,862
JBrowse link
G Clstn3 calsyntenin 3 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of CLSTN3 mRNA CTD PMID:22401849 NCBI chr 4:157,044,736...157,078,013
Ensembl chr 4:157,043,925...157,078,130
JBrowse link
G Cnga2 cyclic nucleotide gated channel subunit alpha 2 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of CNGA2 mRNA CTD PMID:22401849 NCBI chr16:69,878,513...69,899,075
Ensembl chr 1:69,243,659...69,246,983
JBrowse link
G Cnga4 cyclic nucleotide gated channel subunit alpha 4 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of CNGA4 mRNA CTD PMID:22401849 NCBI chr 1:170,238,959...170,246,858
Ensembl chr 1:170,242,846...170,246,858
JBrowse link
G Cntn3 contactin 3 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of CNTN3 mRNA CTD PMID:22401849 NCBI chr 4:134,783,671...135,159,309
Ensembl chr 4:134,784,668...135,069,970
JBrowse link
G Cntnap5b contactin associated protein-like 5B decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of CNTNAP5A mRNA CTD PMID:22401849 NCBI chr13:21,678,088...22,591,082
Ensembl chr13:21,678,512...22,590,586
JBrowse link
G Cntrl centriolin increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of CNTRL mRNA CTD PMID:22401849 NCBI chr 3:14,299,441...14,371,681
Ensembl chr 3:14,299,479...14,371,681
JBrowse link
G Col12a1 collagen type XII alpha 1 chain decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of COL12A1 mRNA CTD PMID:22401849 NCBI chr 8:87,042,820...87,150,701
Ensembl chr 8:87,040,799...87,158,368
JBrowse link
G Col25a1 collagen type XXV alpha 1 chain increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of COL25A1 mRNA CTD PMID:22401849 NCBI chr 2:235,515,364...235,705,448
Ensembl chr 2:235,596,123...235,715,057
JBrowse link
G Col2a1 collagen type II alpha 1 chain increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of COL2A1 mRNA CTD PMID:22401849 NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997
JBrowse link
G Col4a6 collagen type IV alpha 6 chain increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of COL4A6 mRNA CTD PMID:22401849 NCBI chr  X:112,405,647...112,768,337
Ensembl chr  X:112,405,647...112,473,822
JBrowse link
G Cox7a1 cytochrome c oxidase subunit 7A1 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of COX7A1 mRNA CTD PMID:32522588 NCBI chr 1:91,070,593...91,096,190
Ensembl chr 1:91,071,493...91,074,294
Ensembl chr 1:91,071,493...91,074,294
JBrowse link
G Cpa5 carboxypeptidase A5 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of CPA5 mRNA CTD PMID:22401849 NCBI chr 4:57,925,334...57,945,069
Ensembl chr 4:57,925,323...57,945,069
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression
affects expression
ISO mono-(2-ethylhexyl)phthalate results in decreased expression of CPT1A mRNA
mono-(2-ethylhexyl)phthalate affects the expression of CPT1A mRNA
CTD PMID:22401849 PMID:32522588 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of CPT2 mRNA CTD PMID:32522588 NCBI chr 5:127,505,646...127,523,016
Ensembl chr 5:127,505,614...127,523,089
JBrowse link
G Crhbp corticotropin releasing hormone binding protein decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of CRHBP mRNA CTD PMID:22401849 NCBI chr 2:25,141,471...25,153,334
Ensembl chr 2:25,141,471...25,153,334
JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of CRHR2 mRNA CTD PMID:22401849 NCBI chr 4:85,286,371...85,329,374
Ensembl chr 4:85,286,372...85,329,362
JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 multiple interactions ISO [IC 261 results in decreased activity of CSNK1A1 protein] inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased phosphorylation of CELSR2 protein] CTD PMID:16484285 NCBI chr18:56,887,722...56,910,610
Ensembl chr18:56,887,354...56,918,345
JBrowse link
G Cth cystathionine gamma-lyase affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of CTH mRNA CTD PMID:21195148 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046
JBrowse link
G Ctnnb1 catenin beta 1 increases expression
multiple interactions
ISO
EXP
mono-(2-ethylhexyl)phthalate results in increased expression of CTNNB1 mRNA
[Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [mono-(2-ethylhexyl)phthalate affects the localization of CTNNB1 protein]; mono-(2-ethylhexyl)phthalate results in increased expression of and affects the localization of CTNNB1 protein
CTD PMID:22321834 PMID:29940330 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Ctsl cathepsin L increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of CTSL mRNA CTD PMID:16809437 NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279
JBrowse link
G Cubn cubilin decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of CUBN mRNA CTD PMID:22401849 NCBI chr17:80,584,921...80,807,181
Ensembl chr17:80,584,878...80,807,243
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of CXCL1 mRNA CTD PMID:16809437 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression
multiple interactions
EXP
ISO
mono-(2-ethylhexyl)phthalate results in increased expression of CXCL10 mRNA
[bisphenol A co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-benzyl phthalate co-treated with monobutyl phthalate] results in increased expression of CXCL10 mRNA
CTD PMID:16809437 PMID:30398665 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of CXCL1 mRNA CTD PMID:27384973 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cyc1 cytochrome c-1 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of CYC1 mRNA CTD PMID:32522588 NCBI chr 7:117,409,576...117,411,953
Ensembl chr 7:117,409,576...117,411,953
JBrowse link
G Cycs cytochrome c, somatic affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of CYCS mRNA CTD PMID:32522588 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases activity
increases expression
multiple interactions
decreases expression
EXP
ISO
mono-(2-ethylhexyl)phthalate results in increased activity of CYP11A1 protein
mono-(2-ethylhexyl)phthalate results in increased expression of CYP11A1 mRNA
[Genistein co-treated with mono-(2-ethylhexyl)phthalate] results in increased expression of CYP11A1 mRNA; [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CYP11A1 mRNA
mono-(2-ethylhexyl)phthalate results in decreased expression of CYP11A1 mRNA
CTD PMID:22401849 PMID:22525294 PMID:27181934 PMID:29089286 PMID:31884101 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression
multiple interactions
decreases expression
affects expression
EXP
ISO
mono-(2-ethylhexyl)phthalate results in increased expression of CYP17A1 mRNA
[monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CYP17A1 mRNA
mono-(2-ethylhexyl)phthalate results in decreased expression of CYP17A1 mRNA; mono-(2-ethylhexyl)phthalate results in decreased expression of CYP17A1 protein
mono-(2-ethylhexyl)phthalate affects the expression of CYP17A1
CTD PMID:16809437 PMID:19560483 PMID:22087261 PMID:31884101 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity
multiple interactions
increases expression
decreases expression
ISO
EXP
mono-(2-ethylhexyl)phthalate results in decreased activity of CYP19A1 protein
[monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CYP19A1 mRNA
mono-(2-ethylhexyl)phthalate results in increased expression of CYP19A1 mRNA
alitretinoin promotes the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of CYP19A1 mRNA]
mono-(2-ethylhexyl)phthalate inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]
CTD PMID:12706301 PMID:19501113 PMID:19822197 PMID:19874833 PMID:22401849 PMID:29089286 PMID:31884101 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO mono-(2-ethylhexyl)phthalate results in increased expression of CYP1A1 mRNA
[monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in increased expression of CYP1A1 mRNA
CTD PMID:15521013 PMID:31884101 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
multiple interactions
EXP
ISO
mono-(2-ethylhexyl)phthalate results in increased expression of CYP1B1 mRNA
[monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CYP1B1 mRNA
CTD PMID:12706301 PMID:31884101 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases activity EXP mono-(2-ethylhexyl)phthalate results in decreased activity of CYP2C11 protein CTD PMID:27432241 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases metabolic processing
multiple interactions
EXP
ISO
CYP2C6V1 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate
[CYP2C19 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-hydroxyhexyl) phthalate; [CYP2C19 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-oxohexyl)phthalate
[CYP2C6V1 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-hydroxyhexyl) phthalate; [CYP2C6V1 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-oxohexyl)phthalate; [CYP2C6V1 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of phthalic acid
CTD PMID:22186153 PMID:23545481 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing
multiple interactions
EXP CYP3A2 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate
[CYP3A2 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-hydroxyhexyl) phthalate; [CYP3A2 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-oxohexyl)phthalate; [CYP3A2 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of phthalic acid
CTD PMID:22186153 PMID:23545481 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity EXP mono-(2-ethylhexyl)phthalate results in decreased activity of CYP3A62 protein CTD PMID:27432241 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Cyp51 cytochrome P450, family 51 decreases expression EXP mono-(2-ethylhexyl)phthalate results in decreased expression of CYP51 mRNA CTD PMID:22087261 NCBI chr 4:27,175,564...27,194,018
Ensembl chr 4:27,175,243...27,194,018
JBrowse link
G Dach1 dachshund family transcription factor 1 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of DACH1 mRNA CTD PMID:22401849 NCBI chr15:82,095,003...82,482,272
Ensembl chr15:82,099,159...82,482,009
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of DDIT3 mRNA CTD PMID:22321834 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Ddx4 DEAD-box helicase 4 decreases expression EXP mono-(2-ethylhexyl)phthalate results in decreased expression of DDX4 mRNA CTD PMID:30476341 NCBI chr 2:44,447,610...44,504,263
Ensembl chr 2:44,447,573...44,504,354
JBrowse link
G Derl3 derlin 3 affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of DERL3 mRNA CTD PMID:21195148 NCBI chr20:13,692,102...13,707,645
Ensembl chr20:13,704,314...13,706,205
JBrowse link
G Dgkb diacylglycerol kinase, beta decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of DGKB mRNA CTD PMID:22401849 NCBI chr 6:57,516,351...58,277,385
Ensembl chr 6:57,516,713...58,277,279
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of DHCR24 mRNA CTD PMID:23360888 NCBI chr 5:126,164,708...126,188,926
Ensembl chr 5:126,164,674...126,191,206
JBrowse link
G Dhcr7 7-dehydrocholesterol reductase affects expression
decreases expression
EXP
ISO
mono-(2-ethylhexyl)phthalate affects the expression of DHCR7; mono-(2-ethylhexyl)phthalate affects the expression of DHCR7 mRNA
mono-(2-ethylhexyl)phthalate results in decreased expression of DHCR7 mRNA
CTD PMID:16809437 PMID:19560483 PMID:22401849 NCBI chr 1:217,018,916...217,034,890
Ensembl chr 1:217,018,916...217,034,904
JBrowse link
G Dhrs4 dehydrogenase/reductase 4 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of DHRS4 protein CTD PMID:27384973 NCBI chr15:34,155,043...34,167,073
Ensembl chr15:34,155,504...34,167,072
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein decreases expression
increases expression
ISO mono-(2-ethylhexyl)phthalate results in decreased expression of DIABLO mRNA
mono-(2-ethylhexyl)phthalate results in increased expression of DIABLO protein
CTD PMID:18755736 PMID:24706461 NCBI chr12:38,490,230...38,503,344
Ensembl chr12:38,490,230...38,503,330
JBrowse link
G Dipk2a divergent protein kinase domain 2A increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of DIPK2A mRNA CTD PMID:16809437 NCBI chr 8:102,140,713...102,159,828
Ensembl chr 8:102,088,505...102,159,828
JBrowse link
G Disp3 dispatched RND transporter family member 3 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of DISP3 mRNA CTD PMID:22401849 NCBI chr 5:165,051,522...165,099,826
Ensembl chr 5:165,052,871...165,083,487
JBrowse link
G Dmd dystrophin increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of DMD mRNA CTD PMID:22401849 NCBI chr  X:51,149,358...53,519,271
Ensembl chr  X:51,286,737...53,519,259
JBrowse link
G Dmp1 dentin matrix acidic phosphoprotein 1 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of DMP1 mRNA CTD PMID:25777084 NCBI chr14:6,889,851...6,923,961
Ensembl chr14:6,889,856...6,900,733
JBrowse link
G Dnah14 dynein axonemal heavy chain 14 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of DNAH14 mRNA CTD PMID:22401849 NCBI chr13:99,886,373...100,072,674
NCBI chr13:101,936,210...101,973,640
JBrowse link
G Dnah8 dynein, axonemal, heavy chain 8 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of DNAH8 mRNA CTD PMID:22401849 NCBI chr20:9,301,317...9,560,805
Ensembl chr20:9,313,271...9,560,682
JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of DNAJB1 mRNA CTD PMID:24356939 NCBI chr19:24,747,178...24,750,919
Ensembl chr19:24,747,178...24,750,919
JBrowse link
G Dnmt1 DNA methyltransferase 1 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of DNMT1 mRNA CTD PMID:22401849 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G Dock10 dedicator of cytokinesis 10 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of DOCK10 mRNA CTD PMID:22401849 NCBI chr 9:86,424,638...86,571,854
NCBI chr 9:86,312,470...86,423,054
Ensembl chr 9:86,312,501...86,571,870
JBrowse link
G Dock5 dedicator of cytokinesis 5 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of DOCK5 mRNA CTD PMID:22401849 NCBI chr15:44,449,108...44,627,774
Ensembl chr15:44,453,308...44,627,765
JBrowse link
G Dpep1 dipeptidase 1 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of DPEP1 mRNA CTD PMID:22401849 NCBI chr19:55,973,447...55,998,830
Ensembl chr19:55,982,740...55,998,208
JBrowse link
G Dpep2 dipeptidase 2 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of DPEP2 mRNA CTD PMID:22401849 NCBI chr19:37,964,098...37,975,154
Ensembl chr19:37,964,105...37,970,537
JBrowse link
G Dpp6 dipeptidyl peptidase like 6 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of DPP6 mRNA CTD PMID:22401849 NCBI chr 4:4,021,021...4,943,675
Ensembl chr 4:4,021,008...4,473,307
JBrowse link
G Dpy19l1 dpy-19 like C-mannosyltransferase 1 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of DPY19L1 mRNA CTD PMID:22401849 NCBI chr 8:25,582,938...25,669,394
Ensembl chr 8:25,582,938...25,669,394
JBrowse link
G Dpysl4 dihydropyrimidinase-like 4 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of DPYSL4 mRNA CTD PMID:22401849 NCBI chr 1:211,423,022...211,438,533
Ensembl chr 1:211,423,022...211,438,531
JBrowse link
G Dsc2 desmocollin 2 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of DSC2 mRNA CTD PMID:22401849 NCBI chr18:11,826,705...11,858,801
Ensembl chr18:11,826,706...11,858,754
JBrowse link
G Dst dystonin increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of DST mRNA CTD PMID:22401849 NCBI chr 9:37,902,336...38,296,961
Ensembl chr 9:37,902,303...38,196,273
JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression
decreases expression
EXP
ISO
mono-(2-ethylhexyl)phthalate results in increased expression of DUSP1 mRNA
mono-(2-ethylhexyl)phthalate results in decreased expression of DUSP1 mRNA
CTD PMID:16809437 PMID:22401849 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Dusp5 dual specificity phosphatase 5 increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of DUSP5 mRNA CTD PMID:16809437 NCBI chr 1:274,245,184...274,258,595
Ensembl chr 1:274,245,184...274,258,595
JBrowse link
G Dusp6 dual specificity phosphatase 6 increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of DUSP6 mRNA CTD PMID:16809437 NCBI chr 7:41,475,163...41,479,393
Ensembl chr 7:41,475,163...41,479,392
JBrowse link
G Ebf3 EBF transcription factor 3 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of EBF3 mRNA CTD PMID:22401849 NCBI chr 1:209,523,153...209,641,143
Ensembl chr 1:209,523,157...209,641,123
JBrowse link
G Ebp EBP, cholestenol delta-isomerase increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of EBP mRNA CTD PMID:22087261 NCBI chr  X:15,049,394...15,055,782
Ensembl chr  X:15,049,462...15,055,781
JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ECH1 mRNA CTD PMID:32522588 NCBI chr 1:87,009,798...87,015,996
Ensembl chr 1:87,009,730...87,016,005
JBrowse link
G Eci1 enoyl-CoA delta isomerase 1 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ECI1 mRNA CTD PMID:32522588 NCBI chr10:13,797,573...13,810,918
Ensembl chr10:13,797,562...13,810,913
JBrowse link
G Ecm1 extracellular matrix protein 1 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ECM1 mRNA CTD PMID:22401849 NCBI chr 2:197,855,468...197,860,973
Ensembl chr 2:197,855,460...197,860,699
JBrowse link
G Edn1 endothelin 1 increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of EDN1 mRNA CTD PMID:16809437 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Efcab10 EF-hand calcium binding domain 10 affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of EFCAB10 mRNA CTD PMID:21195148 NCBI chr 6:52,702,304...52,709,223
Ensembl chr 6:52,702,544...52,709,223
JBrowse link
G Efhd1 EF-hand domain family, member D1 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of EFHD1 mRNA CTD PMID:22401849 NCBI chr 9:94,362,249...94,408,884
Ensembl chr 9:94,362,299...94,408,885
JBrowse link
G Efnb2 ephrin B2 increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of EFNB2 mRNA CTD PMID:16809437 NCBI chr16:86,631,151...86,672,050
Ensembl chr16:86,631,064...86,675,049
JBrowse link
G Egf epidermal growth factor decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of EGF mRNA CTD PMID:22401849 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egr1 early growth response 1 increases expression EXP
ISO
mono-(2-ethylhexyl)phthalate results in increased expression of EGR1 mRNA CTD PMID:8764118 PMID:16809437 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Egr3 early growth response 3 increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of EGR3 mRNA CTD PMID:16809437 NCBI chr15:51,756,683...51,762,080
Ensembl chr15:51,756,736...51,760,722
JBrowse link
G Egr4 early growth response 4 increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of EGR4 mRNA CTD PMID:16809437 NCBI chr 4:117,293,620...117,296,082
Ensembl chr 4:117,293,620...117,296,082
JBrowse link
G Eif5b eukaryotic translation initiation factor 5B increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of EIF5B mRNA CTD PMID:22401849 NCBI chr 9:44,658,724...44,713,518
Ensembl chr 9:44,681,494...44,713,199
JBrowse link
G Elf1 E74 like ETS transcription factor 1 increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of ELF1 mRNA CTD PMID:16809437 NCBI chr15:61,772,544...61,868,442
Ensembl chr15:61,826,711...61,868,343
JBrowse link
G Enox1 ecto-NOX disulfide-thiol exchanger 1 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of ENOX1 mRNA CTD PMID:22401849 NCBI chr15:59,331,134...59,884,512
Ensembl chr15:59,678,165...59,884,511
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO mono-(2-ethylhexyl)phthalate promotes the reaction [PPARA protein binds to EP300 protein] CTD PMID:20123618 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
JBrowse link
G Epb41l1 erythrocyte membrane protein band 4.1-like 1 affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of EPB41L1 mRNA CTD PMID:21195148 NCBI chr 3:152,492,725...152,622,047
Ensembl chr 3:152,552,822...152,619,722
Ensembl chr 3:152,552,822...152,619,722
JBrowse link
G Epb41l3 erythrocyte membrane protein band 4.1-like 3 affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of EPB41L3 mRNA CTD PMID:21195148 NCBI chr 9:117,314,935...117,666,408
Ensembl chr 9:117,538,009...117,666,410
JBrowse link
G Epdr1 ependymin related 1 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of EPDR1 mRNA CTD PMID:22401849 NCBI chr17:47,397,558...47,422,183
Ensembl chr17:47,397,558...47,422,182
JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of EPHX1 mRNA CTD PMID:12706301 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Ephx2 epoxide hydrolase 2 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of EPHX2 mRNA CTD PMID:22401849 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279
JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of ERBB4 mRNA CTD PMID:22401849 NCBI chr 9:75,021,790...76,178,936
Ensembl chr 9:75,021,790...75,528,644
JBrowse link
G Ern2 endoplasmic reticulum to nucleus signaling 2 multiple interactions ISO mono-(2-ethylhexyl)phthalate promotes the reaction [INS protein results in increased phosphorylation of ERN2 protein] CTD PMID:31009676 NCBI chr 1:192,126,023...192,142,865
Ensembl chr 1:192,126,023...192,142,854
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
affects expression
increases expression
ISO [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of ESR1 mRNA; mono-(2-ethylhexyl)phthalate binds to and results in increased activity of ESR1 protein
mono-(2-ethylhexyl)phthalate affects the expression of ESR1 mRNA
mono-(2-ethylhexyl)phthalate results in increased expression of ESR1 protein
ESR1 protein affects the reaction [mono-(2-ethylhexyl)phthalate affects the expression of ESR1 mRNA]; ESR1 protein affects the reaction [mono-(2-ethylhexyl)phthalate affects the expression of MMP2 mRNA]; ESR1 protein affects the reaction [mono-(2-ethylhexyl)phthalate affects the expression of MMP9 mRNA]; ESR1 protein affects the reaction [mono-(2-ethylhexyl)phthalate affects the expression of TIMP2 mRNA]; ESR1 protein affects the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of PCNA mRNA]; mono-(2-ethylhexyl)phthalate binds to and results in increased activity of ESR1 protein
CTD PMID:20209442 PMID:31884101 PMID:33049310 PMID:33631300 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of ESR2 mRNA
mono-(2-ethylhexyl)phthalate binds to and results in increased activity of ESR2 protein
CTD PMID:31884101 PMID:33049310 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G F10 coagulation factor X decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of F10 mRNA CTD PMID:22401849 NCBI chr16:81,803,169...81,822,476
Ensembl chr16:81,803,110...81,822,716
JBrowse link
G F3 coagulation factor III, tissue factor increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of F3 mRNA CTD PMID:16809437 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fabp3 fatty acid binding protein 3 increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of FABP3 mRNA; mono-(2-ethylhexyl)phthalate results in increased expression of FABP3 protein CTD PMID:12706301 PMID:15647598 NCBI chr 5:148,528,854...148,535,597
Ensembl chr 5:148,528,725...148,535,565
JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression ISO mono-(2-ethylhexyl)phthalate analog results in increased expression of FABP4 mRNA; mono-(2-ethylhexyl)phthalate results in increased expression of FABP4 mRNA; mono-(2-ethylhexyl)phthalate results in increased expression of FABP4 protein CTD PMID:25543134 PMID:25777084 PMID:27384973 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fads6 fatty acid desaturase 6 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of FADS6 mRNA CTD PMID:22401849 NCBI chr10:103,832,838...103,848,035
Ensembl chr10:103,832,838...103,848,035
JBrowse link
G Faim2 Fas apoptotic inhibitory molecule 2 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of FAIM2 mRNA CTD PMID:22401849 NCBI chr 7:141,158,769...141,185,781
Ensembl chr 7:141,157,963...141,185,710
JBrowse link
G Fam126a family with sequence similarity 126, member A decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of FAM126A mRNA CTD PMID:22401849 NCBI chr 4:7,661,710...7,770,179
Ensembl chr 4:7,661,558...7,770,232
JBrowse link
G Far1 fatty acyl CoA reductase 1 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of FAR1 mRNA CTD PMID:22401849 NCBI chr 1:178,351,674...178,412,838
Ensembl chr 1:178,351,680...178,431,395
JBrowse link
G Faslg Fas ligand affects response to substance
multiple interactions
ISO FASL affects the susceptibility to mono-(2-ethylhexyl)phthalate
[FASL affects the susceptibility to mono-(2-ethylhexyl)phthalate] which affects the expression of CFLAR protein
CTD PMID:20100735 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fasn fatty acid synthase increases expression
multiple interactions
decreases expression
ISO mono-(2-ethylhexyl)phthalate results in increased expression of FASN mRNA
mono-(2-ethylhexyl)phthalate results in increased expression of FASN protein
[Genistein co-treated with mono-(2-ethylhexyl)phthalate] results in increased expression of FASN mRNA
mono-(2-ethylhexyl)phthalate results in decreased expression of FASN mRNA
CTD PMID:23118965 PMID:25543134 PMID:27181934 PMID:27384973 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fat1 FAT atypical cadherin 1 decreases expression EXP mono-(2-ethylhexyl)phthalate results in decreased expression of FAT1 mRNA CTD PMID:22087261 NCBI chr16:50,372,150...50,501,716
Ensembl chr16:50,372,128...50,501,921
JBrowse link
G Fbln2 fibulin 2 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of FBLN2 mRNA CTD PMID:22401849 NCBI chr 4:122,835,237...122,895,127
Ensembl chr 4:122,835,436...122,895,121
JBrowse link
G Fbxl22 F-box and leucine-rich repeat protein 22 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of FBXL22 mRNA CTD PMID:22401849 NCBI chr 8:72,198,043...72,204,730
Ensembl chr 8:72,198,043...72,204,730
JBrowse link
G Fcgbp Fc fragment of IgG binding protein increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of FCGBP mRNA CTD PMID:22401849 NCBI chr 1:85,003,280...85,046,840
Ensembl chr 1:85,003,280...85,046,840
JBrowse link
G Fdps farnesyl diphosphate synthase decreases expression ISO
EXP
mono-(2-ethylhexyl)phthalate results in decreased expression of FDPS mRNA CTD PMID:22087261 PMID:22401849 NCBI chr 2:188,403,595...188,413,219
Ensembl chr 2:188,392,858...188,413,219
JBrowse link
G Fdx1 ferredoxin 1 decreases expression ISO
EXP
mono-(2-ethylhexyl)phthalate results in decreased expression of FDX1 mRNA CTD PMID:22087261 PMID:22401849 NCBI chr 8:56,373,729...56,393,199
Ensembl chr 8:56,373,723...56,393,233
JBrowse link
G Fdxr ferredoxin reductase decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of FDXR mRNA CTD PMID:22401849 NCBI chr10:103,817,724...103,826,413
Ensembl chr10:103,817,704...103,826,448
JBrowse link
G Fer1l5 fer-1-like family member 5 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of FER1L5 mRNA CTD PMID:22401849 NCBI chr 9:42,943,362...42,998,126
Ensembl chr 9:42,945,358...42,998,109
JBrowse link
G Fgf21 fibroblast growth factor 21 increases expression
increases secretion
multiple interactions
ISO mono-(2-ethylhexyl)phthalate results in increased expression of FGF21 mRNA
mono-(2-ethylhexyl)phthalate results in increased secretion of FGF21 protein
alpha-cyano-4-hydroxycinnamate inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of FGF21 mRNA]; PPARA gene mutant form inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of FGF21 mRNA]; PPARA inhibits the reaction [PPARA gene mutant form inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of FGF21 mRNA]]
CTD PMID:20123618 PMID:31009676 PMID:32522588 NCBI chr 1:101,595,579...101,596,822
Ensembl chr 1:101,595,579...101,596,822
JBrowse link
G Fgf8 fibroblast growth factor 8 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of FGF8 mRNA CTD PMID:31711903 NCBI chr 1:265,492,949...265,498,965
Ensembl chr 1:265,493,124...265,498,831
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of FGFR3 mRNA CTD PMID:31009676 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706
JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 increases expression ISO mono-(2-ethylhexyl)phthalate results in increased expression of FGFR4 mRNA CTD PMID:31009676 NCBI chr17:9,990,072...10,004,339
Ensembl chr17:9,990,078...10,004,321
JBrowse link
G Fibin fin bud initiation factor homolog increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of FIBIN mRNA CTD PMID:16809437 NCBI chr 3:101,545,207...101,547,478
Ensembl chr 3:101,545,208...101,547,478
JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of FKBP1A mRNA CTD PMID:22401849 NCBI chr 3:147,042,944...147,062,725
Ensembl chr 3:147,042,944...147,062,724
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of FKBP5 mRNA CTD PMID:22401849 NCBI chr20:7,976,704...8,097,290
Ensembl chr20:7,976,713...8,019,020
JBrowse link
G Flg filaggrin multiple interactions ISO [FLG gene polymorphism affects the susceptibility to Diethylhexyl Phthalate] which affects the abundance of mono-(2-ethylhexyl)phthalate CTD PMID:24380925 NCBI chr 2:193,565,401...193,574,297 JBrowse link
G Fmnl3 formin-like 3 decreases expression ISO mono-(2-ethylhexyl)phthalate results in decreased expression of FMNL3 mRNA CTD PMID:22401849 NCBI chr 7:140,981,801...141,033,318
Ensembl chr 7:140,983,342...141,001,993
JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of FMO2 mRNA CTD PMID:16809437 NCBI chr13:80,752,526...80,775,264
Ensembl chr13:80,755,058...80,775,264
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 increases expression EXP mono-(2-ethylhexyl)phthalate results in increased expression of FMO3 mRNA CTD PMID:16809437 NCBI chr13:80,837,418...80,856,214
Ensembl chr13:80,837,420...80,862,963
JBrowse link
G Folr1 folate receptor alpha affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of FOLR1 mRNA CTD PMID:27167697 NCBI chr 1:166,934,457...166,945,864
Ensembl chr 1:166,934,460...166,943,592
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
EXP
ISO
mono-(2-ethylhexyl)phthalate results in increased expression of FOS mRNA
mono-(2-ethylhexyl)phthalate inhibits the reaction [GDNF protein results in increased expression of FOS mRNA]; mono-(2-ethylhexyl)phthalate inhibits the reaction [GDNF protein results in increased expression of FOS protein]
CTD PMID:8764118 PMID:16809437 PMID:22564763 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Foxa1 forkhead box A1 affects expression ISO mono-(2-ethylhexyl)phthalate affects the expression of FOXA1 mRNA CTD PMID:21195148 NCBI chr 6:78,516,579...78,549,669
Ensembl chr 6:78,545,804...78,549,669
JBrowse link