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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tomatidane
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Accession:CHEBI:36196 term browser browse the term
Definition:A spirosolane that has formula C27H45NO.
Synonyms:exact_synonym: (22S,25S)-spirosolane
 related_synonym: (22S,25S)-tomatanine;   Formula=C27H45NO;   InChI=1S/C27H45NO/c1-17-10-14-27(28-16-17)18(2)24-23(29-27)15-22-20-9-8-19-7-5-6-12-25(19,3)21(20)11-13-26(22,24)4/h17-24,28H,5-16H2,1-4H3/t17-,18-,19?,20+,21-,22-,23-,24-,25-,26-,27-/m0/s1;   InChIKey=KOZCINYDCJVLDW-LWXZRZDISA-N;   SMILES=[H][C@]12C[C@@]3([H])[C@]4([H])CCC5CCCC[C@]5(C)[C@@]4([H])CC[C@]3(C)[C@@]1([H])[C@H](C)[C@]1(CC[C@H](C)CN1)O2


show annotations for term's descendants           Sort by:
 
tomatidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase decreases activity ISO tomatidine results in decreased activity of BCHE protein CTD PMID:31152736 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO tomatidine results in decreased phosphorylation of MAPK1 protein CTD PMID:23566884 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO tomatidine results in decreased phosphorylation of MAPK3 protein CTD PMID:23566884 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
multiple interactions
ISO tomatidine results in decreased expression of MMP2 mRNA; tomatidine results in decreased expression of MMP2 protein
tomatidine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 protein modified form]
CTD PMID:23566884 PMID:31545954 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions
ISO tomatidine results in decreased expression of MMP9 mRNA; tomatidine results in decreased expression of MMP9 protein
tomatidine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]
CTD PMID:23566884 PMID:31545954 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Reck reversion-inducing-cysteine-rich protein with kazal motifs increases expression ISO tomatidine results in increased expression of RECK mRNA CTD PMID:23566884 NCBI chr 5:59,348,568...59,415,169
Ensembl chr 5:59,348,639...59,415,135
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO tomatidine results in decreased expression of RELA protein CTD PMID:23566884 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO tomatidine results in increased expression of TIMP1 mRNA CTD PMID:23566884 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19786
    role 19732
      biological role 19732
        biochemical role 19333
          metabolite 19312
            alkaloid 5679
              spirosolane 8
                tomatidane 8
                  tomatidine + 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19786
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19596
                        carbon atom 19586
                          organic molecular entity 19586
                            organic molecule 19519
                              organic cyclic compound 19349
                                organic heterocyclic compound 18574
                                  organonitrogen heterocyclic compound 17604
                                    azaspiro compound 819
                                      spirosolane 8
                                        tomatidane 8
                                          tomatidine + 8
paths to the root