|
G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions decreases expression |
ISO |
Deferoxamine inhibits the reaction [Artesunate results in decreased expression of ACTA2 mRNA] Artesunate results in decreased expression of ACTA2 mRNA; Artesunate results in decreased expression of ACTA2 protein Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] |
CTD |
PMID:30551460 |
|
NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
|
|
G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
affects localization |
ISO |
artesunate affects the localization of AIFM1 protein |
CTD |
PMID:24704559 |
|
NCBI chr X:135,304,063...135,343,062
Ensembl chr X:135,304,066...135,343,087
|
|
G |
Ar |
androgen receptor |
multiple interactions |
ISO |
artesunate binds to and results in decreased activity of AR protein |
CTD |
PMID:25752796 |
|
NCBI chr X:67,656,253...67,828,998
Ensembl chr X:67,656,253...67,829,026
|
|
G |
Atg12 |
autophagy related 12 |
increases expression |
ISO |
Artesunate results in increased expression of ATG12 mRNA |
CTD |
PMID:30551460 |
|
NCBI chr18:40,721,799...40,732,143
Ensembl chr18:40,721,800...40,732,126
|
|
G |
Atg3 |
autophagy related 3 |
increases expression |
ISO |
Artesunate results in increased expression of ATG3 mRNA |
CTD |
PMID:30551460 |
|
NCBI chr11:60,585,192...60,613,706
Ensembl chr11:60,585,171...60,613,718
|
|
G |
Atg5 |
autophagy related 5 |
increases expression |
ISO |
Artesunate results in increased expression of ATG5 mRNA |
CTD |
PMID:30551460 |
|
NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions |
ISO EXP |
artesunate results in increased expression of BAX protein [1,2-Dimethylhydrazine co-treated with artesunate] results in increased expression of BAX protein |
CTD |
PMID:24704559 PMID:29031619 |
|
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions |
ISO EXP |
artesunate results in decreased expression of BCL2 protein [1,2-Dimethylhydrazine co-treated with artesunate] results in decreased expression of BCL2 protein |
CTD |
PMID:24704559 PMID:29031619 |
|
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
|
|
G |
Bst1 |
bone marrow stromal cell antigen 1 |
increases response to substance |
ISO |
BST1 mRNA results in increased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr14:71,798,218...71,814,540
Ensembl chr14:71,798,651...71,814,523
|
|
G |
Casp3 |
caspase 3 |
increases activity |
ISO |
artesunate results in increased activity of CASP3 protein |
CTD |
PMID:19513562 PMID:24704559 |
|
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
|
|
G |
Casp9 |
caspase 9 |
affects expression |
ISO |
artesunate affects the expression of CASP9 protein |
CTD |
PMID:24704559 |
|
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
|
|
G |
Cat |
catalase |
increases expression decreases response to substance |
ISO |
artesunate results in increased expression of CAT protein CAT protein results in decreased susceptibility to artesunate |
CTD |
PMID:19513562 PMID:20144594 |
|
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
|
|
G |
Cct2 |
chaperonin containing TCP1 subunit 2 |
decreases response to substance |
ISO |
CCT2 mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr 7:60,106,532...60,122,779
Ensembl chr 7:60,109,974...60,122,805
|
|
G |
Chek1 |
checkpoint kinase 1 |
multiple interactions increases phosphorylation |
ISO |
APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK1 protein] |
CTD |
PMID:31664825 |
|
NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
|
|
G |
Chek2 |
checkpoint kinase 2 |
multiple interactions increases phosphorylation |
ISO |
APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK2 protein] |
CTD |
PMID:31664825 |
|
NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
|
|
G |
Clip4 |
CAP-GLY domain containing linker protein family, member 4 |
increases response to substance |
ISO |
CLIP4 mRNA results in increased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr 6:23,222,020...23,316,962
Ensembl chr 6:23,222,021...23,316,962
|
|
G |
Coq8a |
coenzyme Q8A |
decreases response to substance |
ISO |
COQ8A mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr13:98,451,629...98,480,438
Ensembl chr13:98,451,637...98,480,419
|
|
G |
Ctnnb1 |
catenin beta 1 |
multiple interactions |
EXP |
artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CTNNB1 protein] |
CTD |
PMID:29031619 |
|
NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
|
|
G |
Dbh |
dopamine beta-hydroxylase |
increases response to substance |
ISO |
DBH mRNA results in increased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898
|
|
G |
Des |
desmin |
multiple interactions decreases expression |
ISO |
Deferoxamine inhibits the reaction [Artesunate results in decreased expression of DES mRNA] Artesunate results in decreased expression of DES mRNA; Artesunate results in decreased expression of DES protein |
CTD |
PMID:30551460 |
|
NCBI chr 9:82,556,574...82,564,288
Ensembl chr 9:82,556,573...82,564,294
|
|
G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
artesunate binds to and results in decreased activity of ESR1 protein |
CTD |
PMID:25752796 |
|
NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
|
|
G |
Fas |
Fas cell surface death receptor |
increases expression |
ISO |
artesunate results in increased expression of FAS protein |
CTD |
PMID:19513562 |
|
NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
|
|
G |
Flna |
filamin A |
increases response to substance |
ISO |
FLNA mRNA results in increased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr X:156,460,785...156,487,245
Ensembl chr X:156,463,953...156,487,245
|
|
G |
Fn1 |
fibronectin 1 |
multiple interactions decreases expression |
ISO |
Deferoxamine inhibits the reaction [Artesunate results in decreased expression of FN1 mRNA] Artesunate results in decreased expression of FN1 mRNA; Artesunate results in decreased expression of FN1 protein |
CTD |
PMID:30551460 |
|
NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
|
|
G |
Fth1 |
ferritin heavy chain 1 |
decreases expression multiple interactions |
ISO |
Artesunate results in decreased expression of FTH1 mRNA; Artesunate results in decreased expression of FTH1 protein Chloroquine inhibits the reaction [Artesunate results in decreased expression of FTH1 mRNA] |
CTD |
PMID:30551460 |
|
NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
|
|
G |
Fzd7 |
frizzled class receptor 7 |
increases response to substance |
ISO |
FZD7 mRNA results in increased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr 9:66,305,731...66,308,550
Ensembl chr 9:66,305,731...66,308,550
|
|
G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
affects response to substance decreases response to substance |
ISO |
GCLC mRNA affects the susceptibility to artesunate GCLC mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:15796179 |
|
NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
|
|
G |
Gclm |
glutamate cysteine ligase, modifier subunit |
decreases response to substance |
ISO |
GCLM mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:15796179 |
|
NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
|
|
G |
Gpx4 |
glutathione peroxidase 4 |
decreases activity multiple interactions |
ISO |
Artesunate results in decreased activity of GPX4 protein Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of GPX4 protein] |
CTD |
PMID:30551460 |
|
NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
|
|
G |
Gstm4 |
glutathione S-transferase mu 4 |
affects response to substance |
ISO |
GSTM4 mRNA affects the susceptibility to artesunate |
CTD |
PMID:15796179 |
|
NCBI chr 2:210,834,013...210,839,242
Ensembl chr 2:210,833,884...210,839,295
|
|
G |
Gstp1 |
glutathione S-transferase pi 1 |
decreases expression |
ISO |
artesunate results in decreased expression of GSTP1 protein |
CTD |
PMID:19513562 |
|
NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
|
|
G |
Gstt2 |
glutathione S-transferase, theta 2 |
affects response to substance |
ISO |
GSTT2 mRNA affects the susceptibility to artesunate |
CTD |
PMID:15796179 |
|
NCBI chr20:13,760,810...13,764,481
Ensembl chr20:13,760,810...13,764,475
|
|
G |
Gstz1 |
glutathione S-transferase zeta 1 |
affects response to substance |
ISO |
GSTZ1 mRNA affects the susceptibility to artesunate |
CTD |
PMID:15796179 |
|
NCBI chr 6:111,176,798...111,187,246
Ensembl chr 6:111,176,798...111,187,244
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
EXP |
Artesunate inhibits the reaction [Ethanol results in increased expression of IL1B protein]; Artesunate inhibits the reaction [Glucose results in increased expression of IL1B mRNA]; Artesunate inhibits the reaction [Glucose results in increased secretion of IL1B protein] |
CTD |
PMID:27474069 PMID:30031708 |
|
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
EXP |
Artesunate inhibits the reaction [Ethanol results in increased expression of IL6 protein]; Artesunate inhibits the reaction [Glucose results in increased expression of IL6 mRNA]; Artesunate inhibits the reaction [Glucose results in increased secretion of IL6 protein] |
CTD |
PMID:27474069 PMID:30031708 |
|
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
|
|
G |
Itgb1 |
integrin subunit beta 1 |
increases response to substance |
ISO |
ITGB1 mRNA results in increased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
|
|
G |
Mgst3 |
microsomal glutathione S-transferase 3 |
affects response to substance |
ISO |
MGST3 mRNA affects the susceptibility to artesunate |
CTD |
PMID:15796179 |
|
NCBI chr13:85,601,499...85,622,392
Ensembl chr13:85,601,499...85,622,314
|
|
G |
Mki67 |
marker of proliferation Ki-67 |
multiple interactions |
EXP |
artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MKI67 protein] |
CTD |
PMID:29031619 |
|
NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
|
|
G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions decreases expression |
EXP ISO |
artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MMP9 protein] Chloroquine inhibits the reaction [Artesunate results in decreased expression of MMP9 mRNA] |
CTD |
PMID:29031619 PMID:30551460 |
|
NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
|
|
G |
Mpo |
myeloperoxidase |
multiple interactions |
EXP |
artesunate inhibits the reaction [Ethanol results in increased activity of MPO protein] |
CTD |
PMID:27474069 |
|
NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
|
|
G |
Mthfd2 |
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase |
decreases response to substance |
ISO |
MTHFD2 mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr 4:115,004,433...115,015,965
Ensembl chr 4:115,004,448...115,015,965
|
|
G |
Myd88 |
MYD88, innate immune signal transduction adaptor |
multiple interactions |
EXP |
artesunate inhibits the reaction [Glucose results in increased expression of MYD88 protein] |
CTD |
PMID:30031708 |
|
NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
|
|
G |
Naca |
nascent polypeptide associated complex subunit alpha |
decreases response to substance |
ISO |
NACA mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr 7:2,458,283...2,470,674
Ensembl chr 7:2,458,264...2,470,674
|
|
G |
Nckap1 |
NCK-associated protein 1 |
increases response to substance |
ISO |
NCKAP1 mRNA results in increased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr 3:67,725,180...67,804,680
Ensembl chr 3:67,725,947...67,787,990
|
|
G |
Ncoa4 |
nuclear receptor coactivator 4 |
multiple interactions decreases expression |
ISO |
Chloroquine inhibits the reaction [Artesunate results in decreased expression of NCOA4 mRNA] Artesunate results in decreased expression of NCOA4 mRNA; Artesunate results in decreased expression of NCOA4 protein |
CTD |
PMID:30551460 |
|
NCBI chr16:8,302,950...8,323,294
Ensembl chr16:8,302,950...8,323,293
|
|
G |
Nfe2l2 |
nuclear factor, erythroid 2-like 2 |
affects localization |
ISO |
artesunate affects the localization of NFE2L2 protein |
CTD |
PMID:26340163 |
|
NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
|
|
G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
multiple interactions |
EXP |
artesunate inhibits the reaction [Glucose results in increased expression of NLRP3 protein] |
CTD |
PMID:30031708 |
|
NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage |
ISO |
artesunate results in increased cleavage of PARP1 protein |
CTD |
PMID:24704559 |
|
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
|
|
G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
EXP |
artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein] |
CTD |
PMID:29031619 |
|
NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
|
|
G |
Pgr |
progesterone receptor |
multiple interactions |
ISO |
artesunate binds to and results in increased activity of PGR protein |
CTD |
PMID:25752796 |
|
NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
[Carbon Tetrachloride results in increased susceptibility to Artesunate] which results in increased expression of PTGS2 mRNA; [Carbon Tetrachloride results in increased susceptibility to Artesunate] which results in increased expression of PTGS2 protein |
CTD |
PMID:30551460 |
|
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP |
artesunate inhibits the reaction [Ethanol results in increased expression of RELA protein]; artesunate inhibits the reaction [Glucose results in increased phosphorylation of RELA protein] |
CTD |
PMID:27474069 PMID:30031708 |
|
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
|
|
G |
Rpa2 |
replication protein A2 |
increases phosphorylation |
ISO |
Artesunate results in increased phosphorylation of RPA2 protein |
CTD |
PMID:31664825 |
|
NCBI chr 5:150,957,041...150,967,597
Ensembl chr 5:150,957,001...150,968,269
|
|
G |
Rpl41 |
ribosomal protein L41 |
decreases response to substance |
ISO |
RPL41 mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr 7:2,972,897...2,973,977
Ensembl chr 7:2,972,900...2,973,977
|
|
G |
Rpl6 |
ribosomal protein L6 |
decreases response to substance |
ISO |
RPL6 mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr12:40,877,578...40,882,032
Ensembl chr12:40,877,613...40,881,124
|
|
G |
Rpl7 |
ribosomal protein L7 |
decreases response to substance |
ISO |
RPL7 mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr 5:2,633,517...2,636,525
Ensembl chr 5:2,632,712...2,640,021
|
|
G |
Rps12 |
ribosomal protein S12 |
decreases response to substance |
ISO |
RPS12 mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr 1:22,758,214...22,760,370
Ensembl chr 1:22,758,212...22,760,370
|
|
G |
Rps15a |
ribosomal protein S15a |
decreases response to substance |
ISO |
RPS15A mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr 1:187,759,865...187,766,734
Ensembl chr 1:187,759,480...187,766,709
|
|
G |
Rps6 |
ribosomal protein S6 |
decreases response to substance |
ISO |
RPS6 mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148
|
|
G |
Slc25a19 |
solute carrier family 25 member 19 |
decreases response to substance |
ISO |
SLC25A19 mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr10:104,166,594...104,179,523
Ensembl chr10:104,166,598...104,179,523
|
|
G |
Sp1 |
Sp1 transcription factor |
decreases expression |
ISO |
artesunate results in decreased expression of SP1 protein |
CTD |
PMID:19513562 |
|
NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
|
|
G |
Sqstm1 |
sequestosome 1 |
multiple interactions decreases expression |
ISO |
Chloroquine inhibits the reaction [Artesunate results in decreased expression of SQSTM1 protein] Artesunate results in decreased expression of SQSTM1 mRNA; Artesunate results in decreased expression of SQSTM1 protein |
CTD |
PMID:30551460 |
|
NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
|
|
G |
Srsf2 |
serine and arginine rich splicing factor 2 |
decreases response to substance |
ISO |
SRSF2 mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr10:105,792,779...105,795,986
Ensembl chr10:105,792,779...105,795,958
|
|
G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
increases expression multiple interactions |
ISO |
Artesunate results in increased expression of TIMP1 mRNA Chloroquine inhibits the reaction [Artesunate results in increased expression of TIMP1 mRNA] |
CTD |
PMID:30551460 |
|
NCBI chr X:1,364,771...1,369,451
Ensembl chr X:1,364,786...1,369,384
|
|
G |
Tlr4 |
toll-like receptor 4 |
multiple interactions |
EXP |
artesunate inhibits the reaction [Glucose results in increased expression of TLR4 protein] |
CTD |
PMID:30031708 |
|
NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
artesunate inhibits the reaction [Ethanol results in increased expression of TNF protein]; artesunate inhibits the reaction [Glucose results in increased expression of TNF mRNA]; artesunate inhibits the reaction [Glucose results in increased secretion of TNF protein] |
CTD |
PMID:27474069 PMID:30031708 |
|
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
|
|
G |
Tpt1 |
tumor protein, translationally-controlled 1 |
affects response to substance |
ISO |
TPT1 protein affects the susceptibility to artesunate |
CTD |
PMID:15878303 |
|
NCBI chr15:57,891,680...57,894,504
Ensembl chr15:57,891,680...57,894,504
|
|
G |
Tufm |
Tu translation elongation factor, mitochondrial |
decreases response to substance |
ISO |
TUFM mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr 1:197,903,582...197,907,189
Ensembl chr 1:197,903,582...197,907,189
|
|
G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
EXP |
artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of VEGFA protein] |
CTD |
PMID:29031619 |
|
NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
|
|
G |
Yy1 |
YY1 transcription factor |
decreases expression |
ISO |
artesunate results in decreased expression of YY1 protein |
CTD |
PMID:19513562 |
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NCBI chr 6:132,702,443...132,726,848
Ensembl chr 6:132,702,448...132,727,046
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G |
Zbtb4 |
zinc finger and BTB domain containing 4 |
increases response to substance |
ISO |
ZBTB4 mRNA results in increased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr10:56,367,586...56,388,296
Ensembl chr10:56,381,813...56,385,960
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions |
ISO |
[hydrocortisone hemisuccinate co-treated with Dimethyl Sulfoxide] results in increased expression of CYP1A2 |
CTD |
PMID:18347083 |
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NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
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G |
Cyp3a62 |
cytochrome P450, family 3, subfamily a, polypeptide 62 |
multiple interactions |
ISO |
[hydrocortisone hemisuccinate co-treated with Dimethyl Sulfoxide] results in increased expression of CYP3A4 |
CTD |
PMID:18347083 |
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NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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G |
F2 |
coagulation factor II |
affects expression |
ISO |
hydrocortisone hemisuccinate affects the expression of F2 protein |
CTD |
PMID:12542493 |
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NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
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G |
Il18 |
interleukin 18 |
decreases secretion |
ISO |
hydrocortisone hemisuccinate results in decreased secretion of IL18 protein |
CTD |
PMID:20421217 |
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NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
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G |
Il1b |
interleukin 1 beta |
decreases secretion |
ISO |
hydrocortisone hemisuccinate results in decreased secretion of IL1B protein |
CTD |
PMID:20421217 |
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NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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G |
Il6 |
interleukin 6 |
decreases secretion |
ISO |
hydrocortisone hemisuccinate results in decreased secretion of IL6 protein |
CTD |
PMID:20421217 |
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NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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G |
Tnf |
tumor necrosis factor |
decreases secretion |
ISO |
hydrocortisone hemisuccinate results in decreased secretion of TNF protein |
CTD |
PMID:20421217 |
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NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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G |
Ces2h |
carboxylesterase 2H |
multiple interactions increases hydrolysis |
EXP |
Dexamethasone promotes the reaction [CES2 protein results in increased hydrolysis of Methylprednisolone Hemisuccinate] |
CTD |
PMID:15794950 |
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NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
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G |
Slc2a4 |
solute carrier family 2 member 4 |
multiple interactions |
ISO |
[alpha-ketoisocaproic acid co-treated with monomethyl succinate] inhibits the reaction [Palmitates results in decreased expression of SLC2A4 mRNA] |
CTD |
PMID:21802492 |
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NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
monomethyl succinate inhibits the reaction [bis((2-oxindol-3-ylimino)-2-(2-aminoethyl)pyridine-N,N')copper(II) results in increased expression of TP53 protein] |
CTD |
PMID:21548882 |
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NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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G |
Acat1 |
acetyl-CoA acetyltransferase 1 |
multiple interactions |
ISO |
sarpogrelate inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]; sarpogrelate metabolite inhibits the reaction [Serotonin results in increased expression of ACAT1 protein] |
CTD |
PMID:16157345 |
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NCBI chr 8:58,166,990...58,195,884
Ensembl chr 8:58,166,990...58,195,884
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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
increases expression |
ISO |
sarpogrelate results in increased expression of ADIPOQ protein |
CTD |
PMID:18235151 |
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NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
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G |
Adra1a |
adrenoceptor alpha 1A |
multiple interactions |
ISO |
sarpogrelate inhibits the reaction [Prazosin binds to ADRA1A protein] |
CTD |
PMID:11937776 |
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NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
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G |
Adra1b |
adrenoceptor alpha 1B |
multiple interactions |
ISO |
sarpogrelate inhibits the reaction [Prazosin binds to ADRA1B protein] |
CTD |
PMID:11937776 |
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NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644
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G |
Adra1d |
adrenoceptor alpha 1D |
multiple interactions |
ISO |
sarpogrelate inhibits the reaction [Prazosin binds to ADRA1D protein] |
CTD |
PMID:11937776 |
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NCBI chr 3:124,129,558...124,145,566
Ensembl chr 3:124,129,558...124,145,566
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
[sarpogrelate results in increased activity of AKT1 protein] inhibits the reaction [Serotonin results in increased ubiquitination of and results in increased degradation of IRS1 protein] |
CTD |
PMID:22975078 |
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NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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G |
Atp2a2 |
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 |
affects expression |
EXP |
sarpogrelate affects the expression of ATP2A2 mRNA; sarpogrelate affects the expression of ATP2A2 protein |
CTD |
PMID:18088389 |
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NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions decreases expression |
ISO |
sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CCL2 protein] sarpogrelate results in decreased expression of CCL2 protein |
CTD |
PMID:18235151 PMID:26824242 |
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NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
decreases activity multiple interactions |
ISO |
sarpogrelate metabolite results in decreased activity of CYP2D6 protein; sarpogrelate results in decreased activity of CYP2D6 protein sarpogrelate inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan]; sarpogrelate metabolite inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan] |
CTD |
PMID:24167220 |
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NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
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G |
Fabp1 |
fatty acid binding protein 1 |
multiple interactions |
ISO |
sarpogrelate inhibits the reaction [Oxygen deficiency results in increased expression of FABP1 protein] |
CTD |
PMID:24107419 |
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NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
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G |
Htr1b |
5-hydroxytryptamine receptor 1B |
multiple interactions |
EXP |
sarpogrelate inhibits the reaction [Iodocyanopindolol binds to HTR1B protein]; sarpogrelate metabolite inhibits the reaction [Iodocyanopindolol binds to HTR1B protein] |
CTD |
PMID:8937629 |
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NCBI chr 8:89,113,984...89,130,830
Ensembl chr 8:89,129,453...89,130,991
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G |
Htr2a |
5-hydroxytryptamine receptor 2A |
multiple interactions affects binding |
ISO EXP |
sarpogrelate binds to and results in decreased activity of HTR2A protein; sarpogrelate binds to and results in decreased activity of HTR2A protein mutant form; sarpogrelate metabolite binds to and results in decreased activity of HTR2A protein sarpogrelate binds to HTR2A protein; sarpogrelate metabolite binds to HTR2A protein |
CTD |
PMID:8937629 PMID:16974069 PMID:17031071 PMID:19672037 |
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NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
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G |
Htr2c |
5-hydroxytryptamine receptor 2C |
affects binding |
ISO |
sarpogrelate binds to HTR2C protein |
CTD |
PMID:16880620 |
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NCBI chr X:118,084,520...118,318,040
Ensembl chr X:118,084,890...118,318,039
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
sarpogrelate inhibits the reaction [Glucose results in increased expression of ICAM1 protein] |
CTD |
PMID:23111892 |
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NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
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G |
Il18 |
interleukin 18 |
decreases expression |
ISO |
sarpogrelate results in decreased expression of IL18 protein |
CTD |
PMID:15080020 |
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NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
sarpogrelate inhibits the reaction [Serotonin results in increased expression of and results in increased secretion of IL6 protein] |
CTD |
PMID:11076827 |
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NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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G |
Irs1 |
insulin receptor substrate 1 |
multiple interactions |
ISO |
[sarpogrelate results in increased activity of AKT1 protein] inhibits the reaction [Serotonin results in increased ubiquitination of and results in increased degradation of IRS1 protein] |
CTD |
PMID:22975078 |
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NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
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G |
Kdr |
kinase insert domain receptor |
multiple interactions |
ISO |
sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of KDR protein] |
CTD |
PMID:27097221 |
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NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
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G |
Mmp13 |
matrix metallopeptidase 13 |
multiple interactions |
EXP |
sarpogrelate inhibits the reaction [Oxygen deficiency results in increased expression of MMP13 mRNA] |
CTD |
PMID:25931318 |
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NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
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G |
Mtor |
mechanistic target of rapamycin kinase |
multiple interactions |
ISO |
sarpogrelate inhibits the reaction [Palmitic Acid results in increased activity of MTOR protein]; sarpogrelate inhibits the reaction [Serotonin results in increased activity of MTOR protein] |
CTD |
PMID:27133527 |
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NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
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G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions |
EXP |
sarpogrelate promotes the reaction [Oxygen deficiency results in increased expression of NOS3 protein] |
CTD |
PMID:25931318 |
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NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
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G |
Pecam1 |
platelet and endothelial cell adhesion molecule 1 |
multiple interactions |
ISO |
sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of PECAM1 protein] |
CTD |
PMID:27097221 |
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NCBI chr10:94,850,971...94,913,202
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G |
Pln |
phospholamban |
affects expression |
EXP |
sarpogrelate affects the expression of PLN mRNA; sarpogrelate affects the expression of PLN protein |
CTD |
PMID:18088389 |
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NCBI chr20:34,633,157...34,642,904
Ensembl chr20:34,633,157...34,642,904
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
EXP |
sarpogrelate inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of PTGS2 protein] |
CTD |
PMID:21262218 |
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NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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G |
Serpine2 |
serpin family E member 2 |
decreases expression multiple interactions |
ISO |
sarpogrelate results in decreased expression of SERPINE2 mRNA sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SERPINE2 protein]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased expression of SERPINE2 mRNA]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein] |
CTD |
PMID:24107419 PMID:27097221 |
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NCBI chr 9:85,560,852...85,629,410
Ensembl chr 9:85,560,863...85,626,094
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G |
Slc2a1 |
solute carrier family 2 member 1 |
affects expression |
EXP |
sarpogrelate affects the expression of SLC2A1 protein |
CTD |
PMID:21183729 |
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NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
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G |
Slc2a4 |
solute carrier family 2 member 4 |
affects expression |
EXP |
sarpogrelate affects the expression of SLC2A4 protein |
CTD |
PMID:21183729 |
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NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
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G |
Sorl1 |
sortilin related receptor 1 |
multiple interactions |
ISO |
sarpogrelate inhibits the reaction [Serotonin results in increased expression of SORL1 mRNA] |
CTD |
PMID:24650663 |
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NCBI chr 8:46,228,077...46,287,171
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TGFB1 protein]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased expression of SERPINE2 mRNA]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein] |
CTD |
PMID:24107419 PMID:27097221 |
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NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
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G |
Ugt1a5 |
UDP glucuronosyltransferase family 1 member A5 |
increases glucuronidation |
ISO |
UGT1A4 protein results in increased glucuronidation of sarpogrelate metabolite |
CTD |
PMID:23704698 |
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NCBI chr 9:95,256,628...95,302,822
Ensembl chr 9:95,161,157...95,302,822
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G |
Ugt1a9 |
UDP glucuronosyltransferase family 1 member A9 |
increases glucuronidation |
ISO |
UGT1A9 protein results in increased glucuronidation of sarpogrelate metabolite |
CTD |
PMID:23704698 |
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NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions |
ISO |
sarpogrelate inhibits the reaction [[Glucose co-treated with Serotonin] results in increased expression of VCAM1 protein] |
CTD |
PMID:22785018 |
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NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
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G |
Bche |
butyrylcholinesterase |
increases response to substance increases metabolic processing increases hydrolysis affects hydrolysis affects response to substance decreases hydrolysis decreases abundance multiple interactions |
ISO |
BCHE gene mutant form results in increased susceptibility to Succinylcholine; BCHE gene polymorphism results in increased susceptibility to Succinylcholine; BCHE protein mutant form results in increased susceptibility to Succinylcholine BCHE protein results in increased metabolism of Succinylcholine BCHE protein results in increased hydrolysis of Succinylcholine BCHE protein mutant form affects the hydrolysis of Succinylcholine BCHE affects the susceptibility to Succinylcholine; BCHE gene mutant form affects the susceptibility to Succinylcholine; BCHE gene polymorphism affects the susceptibility to Succinylcholine; BCHE protein affects the susceptibility to Succinylcholine BCHE protein mutant form results in decreased hydrolysis of Succinylcholine BCHE protein results in decreased abundance of Succinylcholine [Dichlorvos results in decreased activity of BCHE protein] which results in increased susceptibility to Succinylcholine; Insecticides inhibits the reaction [BCHE protein results in increased metabolism of Succinylcholine]; Organophosphorus Compounds inhibits the reaction [BCHE protein results in increased metabolism of Succinylcholine]; Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine] |
CTD |
PMID:726855 PMID:900467 PMID:987736 PMID:1058931 PMID:1147298 PMID:1218148 PMID:1218179 PMID:1734774 PMID:1781528 PMID:2249680 PMID:2432808 PMID:4319258 PMID:4698763 PMID:4728581 PMID:4746059 PMID:4850696 PMID:4985882 PMID:4998912 PMID:5365519 PMID:5412891 PMID:5488351 PMID:5673118 PMID:6465587 PMID:6859614 PMID:6928942 PMID:7069741 PMID:7294376 PMID:7378868 PMID:7793179 PMID:8179139 PMID:9110359 PMID:12190811 PMID:12881446 PMID:15688329 PMID:15826794 PMID:16788378 PMID:16884476 PMID:18075469 PMID:18399847 PMID:18555211 PMID:21029050 PMID:21228368 PMID:25054547 |
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NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
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G |
Chrna4 |
cholinergic receptor nicotinic alpha 4 subunit |
multiple interactions |
ISO |
Succinylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
CTD |
PMID:14645658 |
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NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208
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G |
Chrnb2 |
cholinergic receptor nicotinic beta 2 subunit |
multiple interactions |
ISO |
Succinylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
CTD |
PMID:14645658 |
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NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
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G |
Mb |
myoglobin |
increases secretion |
ISO |
Succinylcholine results in increased secretion of MB protein |
CTD |
PMID:8217179 |
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NCBI chr 7:118,101,633...118,108,864
Ensembl chr 7:118,101,634...118,108,864
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G |
Pklr |
pyruvate kinase L/R |
decreases activity |
EXP |
suxibuzone results in decreased activity of PKLR protein |
CTD |
PMID:3107799 |
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NCBI chr 2:188,449,158...188,458,034
Ensembl chr 2:188,449,210...188,459,592
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