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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:oxo dicarboxylic acid
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Accession:CHEBI:36145 term browser browse the term
Definition:Any dicarboxylic acid carrying one or more oxo groups.
Synonyms:related_synonym: oxo dicarboxylic acids
 cyclic_relationship: is_conjugate_acid_of CHEBI:133294



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2-oxoadipic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of alpha-ketoadipic acid CTD PMID:20567778 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
oxaloacetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Got1 glutamic-oxaloacetic transaminase 1 increases expression ISO Oxaloacetic Acid results in increased expression of GOT1 mRNA CTD PMID:26811028 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
JBrowse link
G Mdh1 malate dehydrogenase 1 increases expression ISO Oxaloacetic Acid results in increased expression of MDH1 protein CTD PMID:26811028 NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925
JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II increases expression ISO Oxaloacetic Acid results in increased expression of COX2 mRNA; Oxaloacetic Acid results in increased expression of COX2 protein CTD PMID:26811028 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Oxaloacetic Acid results in increased expression of PPARGC1A mRNA; Oxaloacetic Acid results in increased expression of PPARGC1A protein CTD PMID:23056435 PMID:26811028 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Ppargc1b PPARG coactivator 1 beta increases expression ISO Oxaloacetic Acid results in increased expression of PPARGC1B protein CTD PMID:26811028 NCBI chr18:54,758,891...54,861,103
Ensembl chr18:54,758,902...54,861,194
JBrowse link
G Pprc1 PPARG related coactivator 1 increases expression ISO Oxaloacetic Acid results in increased expression of PPRC1 mRNA; Oxaloacetic Acid results in increased expression of PPRC1 protein CTD PMID:26811028 NCBI chr 1:244,901,985...244,918,587
Ensembl chr 1:244,902,179...244,918,587
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO Oxaloacetic Acid results in increased expression of and results in increased phosphorylation of SIRT1 protein CTD PMID:26811028 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO Oxaloacetic Acid results in increased expression of TFAM mRNA CTD PMID:26811028 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    role 20009
      chemical role 19539
        donor 18843
          Bronsted acid 18726
            oxoacid 18684
              carbon oxoacid 18569
                carboxylic acid 18565
                  oxo carboxylic acid 6303
                    oxo dicarboxylic acid 9
                      (2E,4Z)-4-Hydroxy-6-oxo-2,4-octadienedioic acid 0
                      (2S)-2-isopropyl-3-oxosuccinic acid 0
                      (2Z,4E)-4-amino-6-oxohepta-2,4-dienedioic acid 0
                      (2Z,4E)-4-hydroxy-6-oxoocta-2,4-dienedioic acid 0
                      (4Z)-2-oxohept-4-enedioic acid 0
                      (S)-2-acetamido-6-oxopimelic acid 0
                      (S)-2-amino-6-oxopimelic acid + 0
                      (Z)-5-oxohex-2-enedioic acid 0
                      (Z)-6-amino-2-hydroxy-4-(2-oxovinyl)hept-3-enedioic acid 0
                      (oxaloamino)benzoic acid + 0
                      13,14-dihydro-15-oxo-20-carboxy-PGF2alpha 0
                      2,3,4,5-tetranor-prostaglandin FM 0
                      2,3,5-trichloromaleylacetic acid 0
                      2,4-dichloro-3-oxoadipic acid 0
                      2,4-dioxopentanedioic acid 0
                      2,5-dichloro-4-oxohex-2-enedioic acid 0
                      2-amino-3-(3-oxoprop-1-enyl)but-2-enedioic acid + 0
                      2-amino-3-oxoadipic acid 0
                      2-chloro-3-oxoadipic acid 0
                      2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoic acid 0
                      2-hydroxy-3-carboxybenzylidenepyruvic acid 0
                      2-hydroxy-3-oxoadipic acid 0
                      2-hydroxy-3-oxosuccinic acid + 0
                      2-oxoadipic acid 1
                      2-oxoglutaric acid + 0
                      2-oxohept-4-ene-1,7-dioic acid 0
                      2-oxohex-3-enedioic acid + 0
                      2-oxopimelic acid 0
                      2-oxosuberic acid 0
                      3-oxalobenzoic acid 0
                      3-oxoadipic acid + 0
                      3-oxopimelic acid + 0
                      4,6-dioxohept-2-enedioic acid + 0
                      4-fumarylacetoacetic acid 0
                      4-hydroxy-2-oxoglutaric acid + 0
                      4-hydroxy-2-oxoheptanedioic acid + 0
                      4-hydroxy-4-methyl-2-oxoadipic acid 0
                      4-hydroxy-4-methyl-2-oxoglutaric acid 0
                      4-maleylacetoacetic acid 0
                      4-nitro-6-oxohepta-2,4-dienedioic acid 0
                      4-oxohex-2-enedioic acid + 0
                      5-(2'-carboxyethyl)-4,6-dihydroxypicolinic acid 0
                      5-(3'-carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinic acid 0
                      5-(3'-carboxy-3'-oxopropyl)-4,6-dihydroxypicolinic acid 0
                      5-dehydro-4-deoxy-D-glucaric acid 0
                      D-prephenyl lactate 0
                      N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine 0
                      dinoflagellate luciferin 0
                      dioxosuccinic acid 0
                      ixazomib citrate 0
                      laccaic acid A + 0
                      laccaic acid B + 0
                      oxaloacetic acid + 8
                      oxidized dinoflagellate luciferin 0
                      oxomalonic acid 0
                      prephenic acid + 0
                      prostaglandin E2-UM 0
                      sennoside A + 0
                      sennoside B + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19873
                          organic molecular entity 19873
                            organic group 18943
                              organic divalent group 18928
                                organodiyl group 18928
                                  carbonyl group 18877
                                    carbonyl compound 18877
                                      carboxylic acid 18565
                                        oxo carboxylic acid 6303
                                          oxo dicarboxylic acid 9
                                            (2E,4Z)-4-Hydroxy-6-oxo-2,4-octadienedioic acid 0
                                            (2S)-2-isopropyl-3-oxosuccinic acid 0
                                            (2Z,4E)-4-amino-6-oxohepta-2,4-dienedioic acid 0
                                            (2Z,4E)-4-hydroxy-6-oxoocta-2,4-dienedioic acid 0
                                            (4Z)-2-oxohept-4-enedioic acid 0
                                            (S)-2-acetamido-6-oxopimelic acid 0
                                            (S)-2-amino-6-oxopimelic acid + 0
                                            (Z)-5-oxohex-2-enedioic acid 0
                                            (Z)-6-amino-2-hydroxy-4-(2-oxovinyl)hept-3-enedioic acid 0
                                            (oxaloamino)benzoic acid + 0
                                            13,14-dihydro-15-oxo-20-carboxy-PGF2alpha 0
                                            2,3,4,5-tetranor-prostaglandin FM 0
                                            2,3,5-trichloromaleylacetic acid 0
                                            2,4-dichloro-3-oxoadipic acid 0
                                            2,4-dioxopentanedioic acid 0
                                            2,5-dichloro-4-oxohex-2-enedioic acid 0
                                            2-amino-3-(3-oxoprop-1-enyl)but-2-enedioic acid + 0
                                            2-amino-3-oxoadipic acid 0
                                            2-chloro-3-oxoadipic acid 0
                                            2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoic acid 0
                                            2-hydroxy-3-carboxybenzylidenepyruvic acid 0
                                            2-hydroxy-3-oxoadipic acid 0
                                            2-hydroxy-3-oxosuccinic acid + 0
                                            2-oxoadipic acid 1
                                            2-oxoglutaric acid + 0
                                            2-oxohept-4-ene-1,7-dioic acid 0
                                            2-oxohex-3-enedioic acid + 0
                                            2-oxopimelic acid 0
                                            2-oxosuberic acid 0
                                            3-oxalobenzoic acid 0
                                            3-oxoadipic acid + 0
                                            3-oxopimelic acid + 0
                                            4,6-dioxohept-2-enedioic acid + 0
                                            4-fumarylacetoacetic acid 0
                                            4-hydroxy-2-oxoglutaric acid + 0
                                            4-hydroxy-2-oxoheptanedioic acid + 0
                                            4-hydroxy-4-methyl-2-oxoadipic acid 0
                                            4-hydroxy-4-methyl-2-oxoglutaric acid 0
                                            4-maleylacetoacetic acid 0
                                            4-nitro-6-oxohepta-2,4-dienedioic acid 0
                                            4-oxohex-2-enedioic acid + 0
                                            5-(2'-carboxyethyl)-4,6-dihydroxypicolinic acid 0
                                            5-(3'-carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinic acid 0
                                            5-(3'-carboxy-3'-oxopropyl)-4,6-dihydroxypicolinic acid 0
                                            5-dehydro-4-deoxy-D-glucaric acid 0
                                            D-prephenyl lactate 0
                                            N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine 0
                                            dinoflagellate luciferin 0
                                            dioxosuccinic acid 0
                                            ixazomib citrate 0
                                            laccaic acid A + 0
                                            laccaic acid B + 0
                                            oxaloacetic acid + 8
                                            oxidized dinoflagellate luciferin 0
                                            oxomalonic acid 0
                                            prephenic acid + 0
                                            prostaglandin E2-UM 0
                                            sennoside A + 0
                                            sennoside B + 0
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