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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:alicyclic ketone
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Accession:CHEBI:36132 term browser browse the term
Definition:A cyclic ketone in which the carbocyclic ring structure which may be saturated or unsaturated, but may not be a benzenoid or other aromatic system.
Synonyms:related_synonym: alicyclic ketones


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(+)-beta-thujone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions ISO beta-thujone inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; beta-thujone inhibits the reaction [Choline results in increased activity of CHRNA7 protein] CTD PMID:28395994 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO beta-thujone inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:15588619 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions ISO beta-thujone inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:15588619 NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO beta-thujone inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:15588619 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
(R)-camphor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col1a2 collagen type I alpha 2 chain affects expression ISO Camphor analog affects the expression of COL1A2 mRNA CTD PMID:24704097 NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity EXP Camphor results in decreased activity of CYP2B1 protein CTD PMID:9242356 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO Camphor inhibits the reaction [CYP2B6 protein results in increased hydrolysis of Bupropion] CTD PMID:18611395 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Camphor binds to and results in increased activity of ESR1 protein CTD PMID:27633901 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO Camphor promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:15588619 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions ISO Camphor promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:15588619 NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO Camphor promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:15588619 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Camphor inhibits the reaction [cinnamic aldehyde results in increased activity of MPO protein] CTD PMID:21466812 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Camphor binds to and results in decreased activity of PGR protein CTD PMID:27633901 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Runx2 RUNX family transcription factor 2 affects expression ISO Camphor analog affects the expression of RUNX2 mRNA CTD PMID:24704097 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Sparc secreted protein acidic and cysteine rich affects expression ISO Camphor analog affects the expression of SPARC mRNA CTD PMID:24704097 NCBI chr10:40,742,390...40,764,232
Ensembl chr10:40,742,400...40,764,185
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP Lidocaine promotes the reaction [Camphor results in increased activity of TRPV1 protein] CTD PMID:18172555 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 increases activity
multiple interactions
ISO Camphor results in increased activity of TRPV3 protein
isopentenyl pyrophosphate inhibits the reaction [Camphor results in increased activity of TRPV3 protein]
CTD PMID:21353389 NCBI chr10:59,829,755...59,863,780
Ensembl chr10:59,831,241...59,860,987
JBrowse link
13,14-dihydro-15-ketoprostaglandin D2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression
multiple interactions
ISO 13,14-dihydro-15-ketoprostaglandin D2 results in increased expression of CXCL2 protein
13,14-dihydro-15-ketoprostaglandin D2 promotes the reaction [Flutamide results in increased expression of CXCL2 mRNA]
CTD PMID:21094227 PMID:21735453 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Gata3 GATA binding protein 3 multiple interactions ISO 13,14-dihydro-15-ketoprostaglandin D2 promotes the reaction [Flutamide results in increased expression of GATA3 mRNA] CTD PMID:21735453 NCBI chr17:72,419,752...72,452,043
Ensembl chr17:72,429,618...72,450,681
JBrowse link
G Il4 interleukin 4 multiple interactions ISO 13,14-dihydro-15-ketoprostaglandin D2 promotes the reaction [Flutamide results in increased expression of IL4 protein] CTD PMID:21735453 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Ptgdr prostaglandin D2 receptor multiple interactions ISO 13,14-dihydro-15-ketoprostaglandin D2 binds to and results in increased activity of PTGDR protein; 13,14-dihydro-15-ketoprostaglandin D2 inhibits the reaction [Prostaglandin D2 binds to PTGDR protein] CTD PMID:9579725 NCBI chr15:19,195,606...19,196,508 JBrowse link
G Ptgdr2 prostaglandin D2 receptor 2 multiple interactions ISO
EXP
13,14-dihydro-15-ketoprostaglandin D2 inhibits the reaction [Prostaglandin D2 binds to PTGDR2 protein]
13,14-dihydro-15-ketoprostaglandin D2 binds to and results in increased activity of PTGDR2 protein
13,14-dihydro-15-ketoprostaglandin D2 binds to and results in increased activity of PTGDR2 protein; ramatroban inhibits the reaction [13,14-dihydro-15-ketoprostaglandin D2 binds to and results in increased activity of PTGDR2 protein]
CTD PMID:12721327 PMID:15528449 PMID:16256979 NCBI chr 1:226,976,455...226,995,641
Ensembl chr 1:226,993,250...226,994,849
JBrowse link
13,14-dihydro-Delta(12)-prostaglandin J2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor increases expression
multiple interactions
EXP 9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of BDNF mRNA
Dactinomycin inhibits the reaction [9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of BDNF mRNA]
CTD PMID:22982731 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions
increases expression
EXP Dactinomycin inhibits the reaction [9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of GDNF mRNA]; NFE2L2 protein affects the reaction [9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of GDNF mRNA] CTD PMID:22982731 NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP NFE2L2 protein affects the reaction [9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of GDNF mRNA] CTD PMID:22982731 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Ngf nerve growth factor multiple interactions
increases expression
EXP Dactinomycin inhibits the reaction [9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of NGF mRNA] CTD PMID:22982731 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
15-deoxy-Delta(12,14)-prostaglandin J2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
affects export
affects glutathionylation
increases transport
ISO [ABCC1 protein results in increased transport of 15-deoxy-delta(12,14)-prostaglandin J2 metabolite] affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; [verlukast binds to and results in decreased activity of ABCC1 protein] inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; ABCC1 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [NFE2L2 protein results in increased expression of GCLC protein]]; ABCC1 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]
ABCC1 protein affects the export of 15-deoxy-delta(12,14)-prostaglandin J2 analog
ABCC1 protein affects the glutathionylation of 15-deoxy-delta(12,14)-prostaglandin J2
CTD PMID:14979731 PMID:21728338 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 affects export ISO ABCC3 protein affects the export of 15-deoxy-delta(12,14)-prostaglandin J2 analog CTD PMID:14979731 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Agt angiotensinogen multiple interactions EXP 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in decreased expression of PPARG protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]] CTD PMID:18278065 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 multiple interactions ISO [Medroxyprogesterone Acetate inhibits the reaction [[AKR1C3 protein results in increased metabolism of Prostaglandin D2] which results in increased abundance of Dinoprost]] which results in increased abundance of 15-deoxy-delta(12,14)-prostaglandin J2 CTD PMID:19997560 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of AKT1 protein CTD PMID:16611854 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bglap bone gamma-carboxyglutamate protein decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of BGLAP mRNA CTD PMID:12021203 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of BIRC2 protein CTD PMID:15498850 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of BIRC3 protein CTD PMID:15498850 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases cleavage
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of CASP3 protein
[delta(12)-prostaglandin J(2) co-treated with 9-deoxy-delta-9-prostaglandin D2 co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in increased cleavage of CASP3 protein
15-deoxy-delta(12,14)-prostaglandin J2 results in increased cleavage of CASP3 protein
15-deoxy-delta(12,14)-prostaglandin J2 results in increased cleavage of and results in increased activity of CASP3 protein
CTD PMID:11785780 PMID:15498850 PMID:16299251 PMID:23973622 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:15498850 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:15498850 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]] CTD PMID:12847270 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Dexamethasone binds to NR3C1 protein] which results in decreased expression of CCL2 protein] CTD PMID:15187150 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA] CTD PMID:23688403 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of and results in increased secretion of CCN2 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of CCN2 mRNA]; SMAD2 protein modified form affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of CCN2]] CTD PMID:19429239 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CCNA2 protein CTD PMID:15729575 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CCNB1 protein CTD PMID:15729575 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CCND3 protein CTD PMID:15729575 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CCNE1 protein CTD PMID:15729575 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CDK2 protein CTD PMID:15729575 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
decreases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of CDKN1A
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CDKN1A protein
CTD PMID:15254749 PMID:15729575 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CDKN1B protein CTD PMID:15729575 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha increases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of CEBPA mRNA CTD PMID:12021203 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CFLAR protein CTD PMID:15498850 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of CHUK protein]
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [manganese chloride results in increased phosphorylation of CHUK protein]
CTD PMID:15498850 PMID:22245093 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of COL1A1 mRNA CTD PMID:12021203 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of CSF2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of CSF2 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of CSF2 mRNA]; Dexamethasone promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of CSF2 mRNA]] CTD PMID:12604364 PMID:14998300 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Ddx58 DEXD/H-box helicase 58 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of DDX58 mRNA] CTD PMID:16303604 NCBI chr 5:56,486,584...56,536,898
Ensembl chr 5:56,500,734...56,536,772
JBrowse link
G Egr1 early growth response 1 multiple interactions EXP 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased activity of EGR1 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Oxygen deficiency results in increased expression of EGR1 mRNA] CTD PMID:12468449 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions
increases expression
ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Tretinoin] results in increased expression of FABP4 mRNA
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of FABP4 mRNA
CTD PMID:9543393 PMID:12021203 PMID:16573735 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of FAS mRNA CTD PMID:16712844 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased activity of [FOS protein binds to JUN protein]]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of FOS mRNA]; U 0126 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of FOS mRNA]; wortmannin inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of FOS mRNA]
CTD PMID:11457450 PMID:11687581 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [NFE2L2 protein results in increased expression of GCLC protein]; [ABCC1 protein results in increased transport of 15-deoxy-delta(12,14)-prostaglandin J2 metabolite] affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; [verlukast binds to and results in decreased activity of ABCC1 protein] inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; ABCC1 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [NFE2L2 protein results in increased expression of GCLC protein]]; ABCC1 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; NFE2L2 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC mRNA; 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein
CTD PMID:21728338 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gfap glial fibrillary acidic protein increases expression
decreases expression
multiple interactions
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GFAP
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of GFAP mRNA
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [ochratoxin A results in decreased expression of GFAP mRNA]
CTD PMID:15254749 PMID:15994020 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 increases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GSTA3 mRNA CTD PMID:14652005 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions ISO GSTM1 protein affects the metabolism of [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Glutathione] CTD PMID:14979731 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression
multiple interactions
EXP 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GSTP1 mRNA; 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GSTP1 protein
Soybean Oil promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GSTP1 mRNA]; Soybean Oil promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GSTP1 protein]
CTD PMID:11600134 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hdac1 histone deacetylase 1 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of HDAC1 mRNA CTD PMID:21957481 NCBI chr 5:147,716,664...147,743,723
Ensembl chr 5:147,716,664...147,743,723
JBrowse link
G Hdac2 histone deacetylase 2 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of HDAC2 mRNA CTD PMID:21957481 NCBI chr20:43,084,870...43,108,198
Ensembl chr20:43,084,870...43,108,198
JBrowse link
G Hdac3 histone deacetylase 3 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of HDAC3 mRNA CTD PMID:21957481 NCBI chr18:31,073,057...31,094,347
Ensembl chr18:31,073,058...31,094,303
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha affects stability
multiple interactions
increases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 affects the stability of HIF1A protein
Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]; Buthionine Sulfoximine promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]; Dithiothreitol inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]
CTD PMID:17658243 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein; [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron; [[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species; [[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased expression of MMP1 mRNA; [[[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species] which results in increased expression of MMP1 protein; Acetylcysteine inhibits the reaction [[[[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species] which results in increased expression of MMP1 protein]; HMOX1 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of MMP1 protein]; HSF1 protein inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HMOX1 mRNA]; NFE2L2 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron]
ochratoxin A inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HMOX1 mRNA]
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HMOX1 mRNA; 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HMOX1 protein
CTD PMID:11078701 PMID:15618017 PMID:15994020 PMID:19136476 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsf1 heat shock transcription factor 1 multiple interactions ISO HSF1 protein inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HMOX1 mRNA] CTD PMID:15618017 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of HSPB1 protein CTD PMID:16299251 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Ifng interferon gamma multiple interactions
decreases expression
decreases secretion
ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased activity of and results in increased localization of [STAT1 protein binds to STAT1 protein]]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased expression of IRF1 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased expression of NOS2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased secretion of IFNG protein]; Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]]; Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; CAT protein inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]]; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; Hydrogen Peroxide promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; peroxyvanadate inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased abundance of Nitric Oxide]]; peroxyvanadate inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; T 0070907 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased secretion of IFNG protein]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of IFNG protein
CTD PMID:12847270 PMID:16844232 PMID:19888466 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of IL1A mRNA] CTD PMID:14998300 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
decreases activity
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein affects the localization of RELA protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in decreased abundance of Prostaglandins]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased abundance of Nitric Oxide]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased activity of [FOS protein binds to JUN protein]]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of CSF2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of CSF2 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of IL1A mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [IL1B protein affects the localization of JUN protein]; Dexamethasone promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of CSF2 mRNA]]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of IL1B protein
[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with IL1B protein] results in decreased secretion of IL1B protein
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of IL1B protein
CTD PMID:11457450 PMID:12604364 PMID:14998300 PMID:15751073 PMID:16461118 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rn interleukin 1 receptor antagonist decreases expression EXP 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of IL1RN mRNA CTD PMID:15751073 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il4 interleukin 4 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; [Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2] CTD PMID:23688403 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL6 protein results in increased phosphorylation of STAT1 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:12604364 PMID:12847270 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Fatty Acids, Nonesterified inhibits the reaction [INS protein results in increased secretion of Glucose]]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of INS mRNA] CTD PMID:14625208 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased expression of IRF1 mRNA] CTD PMID:12847270 NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531
JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]; Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]]; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]] CTD PMID:12847270 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased activity of [FOS protein binds to JUN protein]]; 15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [IL1B protein affects the localization of JUN protein] CTD PMID:11457450 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Klf6 Kruppel-like factor 6 multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of KLF6 protein; RPS6KB1 protein inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of KLF6 protein] CTD PMID:16611854 NCBI chr17:67,887,939...67,945,052
Ensembl chr17:67,887,939...67,945,037
JBrowse link
G Lep leptin multiple interactions
increases secretion
ISO [Dexamethasone co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in decreased secretion of LEP protein
15-deoxy-delta(12,14)-prostaglandin J2 results in increased secretion of LEP protein
CTD PMID:11092516 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lif LIF, interleukin 6 family cytokine multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased expression of STAT3 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased expression of STAT3 protein]]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]]; T 0070907 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased expression of STAT3 protein]]; T 0070907 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]] CTD PMID:19922793 NCBI chr14:84,482,652...84,500,574
Ensembl chr14:84,482,674...84,500,642
JBrowse link
G Lpl lipoprotein lipase increases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of LPL mRNA CTD PMID:12021203 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions
increases phosphorylation
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased phosphorylation of MAPK1 protein
15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of and results in increased activity of MAPK1 protein; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of and results in increased activity of MAPK1 protein]; U 0126 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of and results in increased activity of MAPK1 protein]
15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK1 protein]; [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of MAPK1 protein; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK1 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK1 protein]
CTD PMID:11687581 PMID:12083801 PMID:16611854 PMID:19888466 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions
increases phosphorylation
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased phosphorylation of MAPK3 protein
15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of and results in increased activity of MAPK3 protein; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of and results in increased activity of MAPK3 protein]
15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK3 protein]; [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of MAPK3 protein; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK3 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK3 protein]
CTD PMID:11687581 PMID:12083801 PMID:16611854 PMID:19888466 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Med1 mediator complex subunit 1 multiple interactions ISO MED1 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of PPARG protein] CTD PMID:16324150 NCBI chr10:86,101,560...86,145,271
Ensembl chr10:86,103,600...86,144,880
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions
increases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of MMP1 protein; [[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased expression of MMP1 mRNA; [[[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species] which results in increased expression of MMP1 protein; Acetylcysteine inhibits the reaction [[[[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species] which results in increased expression of MMP1 protein]; Cycloheximide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of MMP1 protein]; Dactinomycin inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of MMP1 protein]; Deferoxamine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of MMP1 mRNA]; Deferoxamine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of MMP1 protein]; HMOX1 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of MMP1 protein]; NFE2L2 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of MMP1 mRNA] CTD PMID:19136476 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of and results in decreased expression of MMP9 protein; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of and results in decreased expression of MMP9 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of MMP9 mRNA] CTD PMID:19997048 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of MTOR protein CTD PMID:16611854 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Nes nestin increases expression EXP 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of NES protein CTD PMID:15212945 NCBI chr 2:187,343,109...187,352,972
Ensembl chr 2:187,344,056...187,352,969
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 affects the localization of and results in increased activity of NFE2L2 protein; 15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [NFE2L2 protein results in increased expression of GCLC protein]; ABCC1 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [NFE2L2 protein results in increased expression of GCLC protein]]; Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of NFE2L2 protein]; NFE2L2 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; NFE2L2 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HMOX1 mRNA]; NFE2L2 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of MMP1 mRNA]
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and affects the localization of NFE2L2 protein; manganese chloride inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of NFE2L2 protein]
CTD PMID:19136476 PMID:21728338 PMID:22245093 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
decreases localization
ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased localization of NFKB1 protein
CTD PMID:11457450 PMID:16299251 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases phosphorylation
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [manganese chloride results in increased degradation of NFKBIA protein]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased phosphorylation of NFKBIA protein
CTD PMID:15498850 PMID:22245093 PMID:23688403 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases activity
decreases expression
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of NOS2 protein
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [ochratoxin A results in increased expression of NOS2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of and results in decreased expression of NOS2 protein
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of NOS2 mRNA
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Bleomycin results in increased expression of NOS2 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased expression of NOS2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of and results in decreased expression of NOS2 protein; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of and results in decreased expression of NOS2 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of NOS2 mRNA]
CTD PMID:11457450 PMID:11890746 PMID:12847270 PMID:15684285 PMID:15994020 PMID:16461118 PMID:19997048 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 decreases activity EXP 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of NOS3 protein CTD PMID:11890746 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects activity
multiple interactions
ISO 15-deoxy-delta(12,14)-prostaglandin J2 affects the activity of NR3C1 protein
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Dexamethasone binds to NR3C1 protein] which results in decreased expression of CCL2 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Dexamethasone binds to NR3C1 protein]
CTD PMID:15187150 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Park7 Parkinsonism associated deglycase multiple interactions EXP 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [manganese chloride results in decreased expression of PARK7 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [manganese chloride results in decreased expression of PARK7 protein] CTD PMID:22245093 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 results in increased cleavage of PARP1 protein
[delta(12)-prostaglandin J(2) co-treated with 9-deoxy-delta-9-prostaglandin D2 co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in increased cleavage of PARP1 protein
CTD PMID:15498850 PMID:23973622 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of PCK1 mRNA CTD PMID:9518257 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in increased activity of PPARA protein CTD PMID:9013583 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of PPARD protein CTD PMID:17341418 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects expression
decreases response to substance
increases expression
increases activity
multiple interactions
decreases expression
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 affects the expression of PPARG
PPARG protein mutant form results in decreased susceptibility to 15-deoxy-delta(12,14)-prostaglandin J2
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of PPARG mRNA; 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of PPARG protein
15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of PPARG protein
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in decreased expression of PPARG protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [ochratoxin A results in increased expression of PPARG mRNA]
15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in increased activity of PPARG protein; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]; MED1 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of PPARG protein]
15-deoxy-delta(12,14)-prostaglandin J2 affects the localization of and results in increased expression of PPARG protein; 15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in decreased activity of PPARG protein; 15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in increased activity of PPARG protein; 15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in increased localization of and results in increased activity of PPARG protein; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [deoxynivalenol results in increased expression of PPARG protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of PPARG mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in decreased expression of PPARG mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of PPARG protein]; MG 262 promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of PPARG protein]; PPARG protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of TBXA2R mRNA alternative form]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of PPARG protein
CTD PMID:9013583 PMID:10662598 PMID:11030710 PMID:12065695 PMID:12604364 PMID:12839938 PMID:12847270 PMID:14625208 PMID:14979731 PMID:14998300 PMID:15212945 PMID:15254749 PMID:15322177 PMID:15491415 PMID:15707588 PMID:15729575 PMID:15866424 PMID:15994020 PMID:16324150 PMID:16499875 PMID:17341418 PMID:18278065 PMID:18485432 PMID:19922793 PMID:23943857 PMID:26172262 PMID:30138673 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in increased expression of PTEN protein CTD PMID:16611854 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptgdr prostaglandin D2 receptor multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in increased activity of PTGDR protein; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Prostaglandin D2 binds to PTGDR protein] CTD PMID:9579725 NCBI chr15:19,195,606...19,196,508 JBrowse link
G Ptgdr2 prostaglandin D2 receptor 2 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in increased activity of PTGDR2 protein; ramatroban inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in increased activity of PTGDR2 protein]
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Prostaglandin D2 binds to PTGDR2 protein]
CTD PMID:12721327 PMID:16256979 NCBI chr 1:226,976,455...226,995,641
Ensembl chr 1:226,993,250...226,994,849
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO PTGS1 protein promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased abundance of 15-deoxy-delta(12,14)-prostaglandin J2] CTD PMID:17439952 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
increases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of and results in decreased expression of PTGS2 protein; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of and results in decreased expression of PTGS2 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of PTGS2 mRNA]
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of PTGS2
CTD PMID:11457450 PMID:12604364 PMID:15254749 PMID:19997048 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 increases phosphorylation EXP 15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of PTPN11 protein CTD PMID:12584205 NCBI chr12:40,895,515...40,955,999
Ensembl chr12:40,895,515...40,955,999
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of and results in decreased phosphorylation of RAF1 protein CTD PMID:12083801 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rarb retinoic acid receptor, beta multiple interactions
increases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [ciglitazone promotes the reaction [SR 11237 results in increased expression of RARB protein]]
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of RARB
CTD PMID:12839938 PMID:15254749 NCBI chr15:9,915,223...10,262,599
Ensembl chr15:10,120,206...10,262,599
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased phosphorylation of and results in decreased expression of RB1 protein CTD PMID:15729575 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases activity
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein affects the localization of RELA protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of RELA protein
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [manganese chloride affects the localization of RELA protein]
CTD PMID:11457450 PMID:15498850 PMID:20174873 PMID:22245093 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of RPS6KA1 protein CTD PMID:16611854 NCBI chr 5:152,078,217...152,122,684
Ensembl chr 5:152,078,220...152,122,684
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of and results in decreased activity of RPS6KB1 protein; RPS6KB1 protein inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased expression of TGFB1 mRNA]; RPS6KB1 protein inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of KLF6 protein] CTD PMID:16611854 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Runx2 RUNX family transcription factor 2 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of RUNX2 mRNA CTD PMID:12021203 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Rxra retinoid X receptor alpha increases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of RXRA CTD PMID:15254749 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions EXP 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]] CTD PMID:18278065 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; SMAD2 protein modified form affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of CCN2]] CTD PMID:19429239 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Socs1 suppressor of cytokine signaling 1 increases expression EXP 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of SOCS1 mRNA CTD PMID:12584205 NCBI chr10:4,956,795...4,958,472
Ensembl chr10:4,957,326...4,958,461
JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression EXP 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of SOCS3 mRNA CTD PMID:12584205 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of SPP1 mRNA CTD PMID:12021203 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL6 protein results in increased phosphorylation of STAT1 protein]
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased activity of and results in increased localization of [STAT1 protein binds to STAT1 protein]]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [peroxyvanadate results in increased phosphorylation of STAT1 protein]; Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; CAT protein inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; Hydrogen Peroxide promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; peroxyvanadate inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]
CTD PMID:12584205 PMID:12847270 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased expression of STAT3 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased expression of STAT3 protein]]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]]; T 0070907 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased expression of STAT3 protein]]; T 0070907 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]]
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]
CTD PMID:12584205 PMID:12847270 PMID:19922793 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tbxa2r thromboxane A2 receptor multiple interactions
decreases expression
ISO PPARG protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of TBXA2R mRNA alternative form] CTD PMID:16499875 NCBI chr 7:11,253,153...11,259,233
Ensembl chr 7:11,253,180...11,257,977
JBrowse link
G Tg thyroglobulin multiple interactions
increases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [TSHB protein results in increased expression of TG protein]
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of TG protein
CTD PMID:11078701 NCBI chr 7:107,467,260...107,652,897
Ensembl chr 7:107,467,260...107,652,899
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression
decreases response to substance
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of and results in increased secretion of CCN2 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of CCN2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; SMAD2 protein modified form affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of CCN2]]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of TGFB1 mRNA
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]
15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [alitretinoin results in decreased expression of TGFB1 mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [[alitretinoin co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in decreased expression of TGFB1 mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [[alitretinoin co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in decreased expression of TGFB1 mRNA]; RPS6KB1 protein inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased expression of TGFB1 mRNA]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased susceptibility to TGFB1 protein
CTD PMID:16611854 PMID:18278065 PMID:19429239 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Th tyrosine hydroxylase increases expression EXP 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of TH protein CTD PMID:15212945 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions
decreases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of TLR2 mRNA
CTD PMID:20174873 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of TNF protein
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
CTD PMID:12604364 PMID:19888466 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [TSHB protein results in increased expression of TG protein] CTD PMID:11078701 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681
JBrowse link
G Tslp thymic stromal lymphopoietin multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein] CTD PMID:23688403 NCBI chr18:25,613,601...25,618,066
Ensembl chr18:25,613,831...25,617,361
JBrowse link
G Vim vimentin decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of VIM CTD PMID:15254749 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Wnt10b Wnt family member 10B decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of WNT10B mRNA CTD PMID:12021203 NCBI chr 7:140,448,284...140,466,159
Ensembl chr 7:140,448,465...140,454,268
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of XIAP protein CTD PMID:15498850 PMID:16299251 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
16,16-dimethylprostaglandin E2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
ISO 16,16-Dimethylprostaglandin E2 results in increased phosphorylation of AKT1 protein
EGFR affects the reaction [16,16-Dimethylprostaglandin E2 results in increased phosphorylation of AKT1 protein]
CTD PMID:15578100 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases response to substance
affects localization
ISO BAX results in increased susceptibility to 16,16-Dimethylprostaglandin E2
16,16-Dimethylprostaglandin E2 affects the localization of BAX protein
CTD PMID:15578100 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO EGFR affects the reaction [16,16-Dimethylprostaglandin E2 results in increased phosphorylation of AKT1 protein] CTD PMID:15578100 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase increases activity ISO 16,16-Dimethylprostaglandin E2 results in increased activity of HPGD protein CTD PMID:14736730 NCBI chr16:37,457,134...37,495,758
Ensembl chr16:37,457,135...37,495,758
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP 16,16-Dimethylprostaglandin E2 inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:11686837 PMID:11855677 PMID:11991626 PMID:18306037 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP 16,16-Dimethylprostaglandin E2 inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; 16,16-Dimethylprostaglandin E2 inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA] CTD PMID:11686837 PMID:11855677 PMID:11991626 PMID:15610444 PMID:18306037 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO
EXP
Flurbiprofen inhibits the reaction [16,16-Dimethylprostaglandin E2 results in increased expression of PTGS2 mRNA]
16,16-Dimethylprostaglandin E2 inhibits the reaction [SC 560 results in increased expression of PTGS2 mRNA]
CTD PMID:9099957 PMID:15610444 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 16,16-Dimethylprostaglandin E2 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF] CTD PMID:9298541 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
2-cyclopenten-1-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO cyclopentenone results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:18383863 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO cyclopentenone results in increased expression of CDKN1B CTD PMID:16061222 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO cyclopentenone results in decreased phosphorylation of RB1 protein CTD PMID:16061222 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
2-methoxyestrone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 multiple interactions ISO [HSD17B2 protein results in increased metabolism of and results in decreased activity of 2-methoxyestradiol] which results in increased chemical synthesis of 2-methoxyestrone CTD PMID:16397246 NCBI chr19:50,246,404...50,317,892
Ensembl chr19:50,246,402...50,317,891
JBrowse link
28-deoxonimbolide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO 28-deoxonimbolide results in increased activity of CASP3 protein CTD PMID:21381696 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity ISO 28-deoxonimbolide results in increased activity of CASP8 protein CTD PMID:21381696 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity ISO 28-deoxonimbolide results in increased activity of CASP9 protein CTD PMID:21381696 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
AH23848 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [GSK3B protein binds to AKT1 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of AKT1 protein CTD PMID:19407222 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Arrb1 arrestin, beta 1 multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [[ARRB1 protein modified form binds to SRC protein] which binds to IL1R1 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [[ARRB1 protein modified form binds to SRC protein] which binds to TNFRSF1A protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [ARRB1 protein modified form binds to SRC protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of ARRB1 protein CTD PMID:19407222 NCBI chr 1:164,502,099...164,573,947
Ensembl chr 1:164,502,389...164,593,139
JBrowse link
G Axin1 axin 1 multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [AXIN1 protein binds to CTNNB1 protein] CTD PMID:19407222
G Bad BCL2-associated agonist of cell death multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [BAD protein binds to BCL2 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [BAD protein binds to BCL2L1 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of BAD protein CTD PMID:19407222 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [BAX protein binds to BCL2 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [BAX protein binds to BCL2L1 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in increased expression of BAX protein CTD PMID:19407222 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [BAD protein binds to BCL2 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [BAX protein binds to BCL2 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of BCL2 protein CTD PMID:19407222 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [BAD protein binds to BCL2L1 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [BAX protein binds to BCL2L1 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of BCL2L1 protein CTD PMID:19407222 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in increased cleavage of and results in increased activity of CASP3 protein
AH 23848 inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased cleavage of CASP3 protein]
CTD PMID:19407222 PMID:32115946 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [AXIN1 protein binds to CTNNB1 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [GSK3B protein binds to CTNNB1 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in increased degradation of CTNNB1 protein CTD PMID:19407222 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions ISO AH 23848 inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA]; AH 23848 inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein]; AH 23848 inhibits the reaction [o,p'-DDT results in increased expression of CYP19A1 mRNA]; AH 23848 inhibits the reaction [o,p'-DDT results in increased expression of CYP19A1 protein] CTD PMID:20678559 PMID:28571770 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO AH 23848 inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 mRNA]; AH 23848 inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 protein] CTD PMID:20093341 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [EGFR protein modified form binds to SRC protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of and results in decreased expression of EGFR protein CTD PMID:19407222 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of EGR1 protein CTD PMID:19407222 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of FOS protein CTD PMID:19407222 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [GSK3B protein binds to AKT1 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [GSK3B protein binds to MAPK1 protein binds to MAPK3 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [GSK3B protein binds to CTNNB1 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of GSK3B protein CTD PMID:19407222 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Il1r1 interleukin 1 receptor type 1 multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [[ARRB1 protein modified form binds to SRC protein] which binds to IL1R1 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of IL1R1 protein CTD PMID:19407222 NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of JUN protein CTD PMID:19407222 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Lep leptin multiple interactions ISO AH 23848 inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA]; AH 23848 inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein] CTD PMID:28571770 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [GSK3B protein binds to MAPK1 protein binds to MAPK3 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of MAPK1 protein CTD PMID:19407222 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [GSK3B protein binds to MAPK1 protein binds to MAPK3 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of MAPK3 protein CTD PMID:19407222 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of MYC protein CTD PMID:19407222 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of NFKB1 protein CTD PMID:19407222 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of NFKBIA protein CTD PMID:19407222 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in increased cleavage of and results in increased activity of PARP1 protein CTD PMID:19407222 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Ptger2 prostaglandin E receptor 2 multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [PTGER2 protein binds to SRC protein] CTD PMID:19407222 NCBI chr15:19,336,029...19,349,759
Ensembl chr15:19,338,175...19,350,210
JBrowse link
G Ptger4 prostaglandin E receptor 4 multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [PTGER4 protein binds to SRC protein] CTD PMID:19407222 NCBI chr 2:54,951,625...54,966,470
Ensembl chr 2:54,952,821...54,963,448
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO AH 23848 inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 mRNA]; AH 23848 inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 protein] CTD PMID:20678559 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of and results in decreased expression of RELA protein CTD PMID:19407222 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of SP1 protein CTD PMID:19407222 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [[ARRB1 protein modified form binds to SRC protein] which binds to IL1R1 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [[ARRB1 protein modified form binds to SRC protein] which binds to TNFRSF1A protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [ARRB1 protein modified form binds to SRC protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [EGFR protein modified form binds to SRC protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [PTGER2 protein binds to SRC protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [PTGER4 protein binds to SRC protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of SRC protein CTD PMID:19407222 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Tcf7 transcription factor 7 multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of TCF7 protein CTD PMID:19407222 NCBI chr10:37,616,033...37,646,027
Ensembl chr10:37,617,279...37,645,802
JBrowse link
G Tcf7l2 transcription factor 7 like 2 multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of TCF7L2 protein CTD PMID:19407222 NCBI chr 1:276,686,911...276,730,517
Ensembl chr 1:276,659,542...276,730,514
Ensembl chr 1:276,659,542...276,730,514
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO AH 23848 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF] CTD PMID:9298541 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [[ARRB1 protein modified form binds to SRC protein] which binds to TNFRSF1A protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of TNFRSF1A protein CTD PMID:19407222 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
azadiradione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO azadiradione results in increased activity of CASP3 protein CTD PMID:21381696 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity ISO azadiradione results in increased activity of CASP8 protein CTD PMID:21381696 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity ISO azadiradione results in increased activity of CASP9 protein CTD PMID:21381696 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO azadiradione results in increased expression of HSPA1A mRNA CTD PMID:30309986 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
beta-damascenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calml5 calmodulin-like 5 increases expression ISO beta-damascenone results in increased expression of CALM4 mRNA CTD PMID:22982537 NCBI chr17:70,044,956...70,045,886 JBrowse link
G Casp14 caspase 14 increases expression
affects localization
ISO beta-damascenone results in increased expression of CASP14 mRNA
beta-damascenone affects the localization of CASP14 protein
CTD PMID:22982537 NCBI chr 7:13,938,376...13,944,286
Ensembl chr 7:13,938,302...13,945,130
JBrowse link
G Ces3a carboxylesterase 3a increases expression ISO beta-damascenone results in increased expression of CES3 mRNA CTD PMID:22982537 NCBI chr19:37,070,705...37,079,411 JBrowse link
G Clca1 chloride channel accessory 1 increases expression ISO beta-damascenone results in increased expression of CLCA1 mRNA CTD PMID:22982537 NCBI chr 2:250,897,980...250,923,711
Ensembl chr 2:250,897,969...250,923,744
JBrowse link
G Clca2 chloride channel accessory 2 increases expression ISO beta-damascenone results in increased expression of CLCA2 mRNA CTD PMID:22982537 NCBI chr 2:250,954,423...250,981,544
Ensembl chr 2:250,954,397...250,981,623
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression ISO beta-damascenone results in increased expression of CYP17A1 mRNA CTD PMID:22982537 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Fcgbp Fc fragment of IgG binding protein increases expression ISO beta-damascenone results in increased expression of FCGBP mRNA CTD PMID:22982537 NCBI chr 1:85,003,280...85,046,840
Ensembl chr 1:85,003,280...85,046,840
JBrowse link
G Flg filaggrin increases expression ISO beta-damascenone results in increased expression of FLG mRNA; beta-damascenone results in increased expression of FLG protein CTD PMID:22982537 NCBI chr 2:193,565,401...193,574,297 JBrowse link
G Hrnr hornerin increases expression ISO beta-damascenone results in increased expression of HRNR mRNA CTD PMID:22982537 NCBI chr 2:193,626,283...193,639,848
Ensembl chr 2:193,627,243...193,634,181
JBrowse link
G Il20ra interleukin 20 receptor subunit alpha increases expression ISO beta-damascenone results in increased expression of IL20RA mRNA CTD PMID:22982537 NCBI chr 1:15,180,328...15,222,785
Ensembl chr 1:15,180,328...15,222,785
JBrowse link
G Il36rn interleukin 36 receptor antagonist increases expression ISO beta-damascenone results in increased expression of IL36RN mRNA CTD PMID:22982537 NCBI chr 3:1,385,256...1,392,275
Ensembl chr 3:1,385,654...1,392,275
JBrowse link
G Krt1 keratin 1 increases expression ISO beta-damascenone results in increased expression of KRT1 mRNA CTD PMID:22982537 NCBI chr 7:143,448,318...143,453,544
Ensembl chr 7:143,448,318...143,453,544
JBrowse link
G Krt10 keratin 10 increases expression ISO beta-damascenone results in increased expression of KRT10 mRNA CTD PMID:22982537 NCBI chr10:87,296,445...87,301,307
Ensembl chr10:87,296,451...87,300,736
JBrowse link
G Lce1d late cornified envelope 1D increases expression ISO beta-damascenone results in increased expression of LCE1D mRNA CTD PMID:22982537
G Lce1f late cornified envelope 1F increases expression ISO beta-damascenone results in increased expression of LCE1F mRNA CTD PMID:22982537 NCBI chr 2:192,990,607...192,992,193
Ensembl chr 2:192,990,831...192,991,199
JBrowse link
G Lce1l late cornified envelope 1L increases expression ISO beta-damascenone results in increased expression of LCE1B mRNA CTD PMID:22982537 NCBI chr 2:193,164,403...193,165,736
Ensembl chr 2:193,164,403...193,165,736
JBrowse link
G Lipm lipase, family member M increases expression ISO beta-damascenone results in increased expression of LIPM mRNA CTD PMID:22982537 NCBI chr 1:252,409,232...252,428,567
Ensembl chr 1:252,409,268...252,428,774
JBrowse link
G Loricrin loricrin cornified envelope precursor protein increases expression ISO beta-damascenone results in increased expression of LOR mRNA CTD PMID:22982537 NCBI chr 2:191,984,455...191,990,713
Ensembl chr 2:191,984,773...191,986,170
JBrowse link
G Otop3 otopetrin 3 increases expression ISO beta-damascenone results in increased expression of OTOP3 mRNA CTD PMID:22982537 NCBI chr10:103,887,045...103,898,331
Ensembl chr10:103,891,369...103,898,331
JBrowse link
G Pla2g4f phospholipase A2, group IVF increases expression ISO beta-damascenone results in increased expression of PLA2G4F mRNA CTD PMID:22982537 NCBI chr 3:112,068,617...112,083,978
Ensembl chr 3:112,072,330...112,084,144
JBrowse link
G Plcxd1 phosphatidylinositol-specific phospholipase C, X domain containing 1 increases expression ISO beta-damascenone results in increased expression of PLCXD1 mRNA CTD PMID:22982537 NCBI chr12:52,674,837...52,678,047
Ensembl chr12:52,641,222...52,676,608
JBrowse link
G Sdr16c5 short chain dehydrogenase/reductase family 16C, member 5 increases expression ISO beta-damascenone results in increased expression of SDR16C5 mRNA CTD PMID:22982537 NCBI chr 5:16,904,926...16,930,111
Ensembl chr 5:16,904,926...16,930,075
JBrowse link
G Susd2 sushi domain containing 2 increases expression ISO beta-damascenone results in increased expression of SUSD2 mRNA CTD PMID:22982537 NCBI chr20:13,965,098...13,972,547
Ensembl chr20:13,965,121...13,972,547
JBrowse link
G Tmprss4 transmembrane serine protease 4 increases expression ISO beta-damascenone results in increased expression of TMPRSS4 mRNA CTD PMID:22982537 NCBI chr 8:49,469,804...49,503,304
Ensembl chr 8:49,469,503...49,502,647
JBrowse link
camphor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col1a2 collagen type I alpha 2 chain affects expression ISO Camphor analog affects the expression of COL1A2 mRNA CTD PMID:24704097 NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity EXP Camphor results in decreased activity of CYP2B1 protein CTD PMID:9242356 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO Camphor inhibits the reaction [CYP2B6 protein results in increased hydrolysis of Bupropion] CTD PMID:18611395 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Camphor binds to and results in increased activity of ESR1 protein CTD PMID:27633901 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO Camphor promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:15588619 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions ISO Camphor promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:15588619 NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO Camphor promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:15588619 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Camphor inhibits the reaction [cinnamic aldehyde results in increased activity of MPO protein] CTD PMID:21466812 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Camphor binds to and results in decreased activity of PGR protein CTD PMID:27633901 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Runx2 RUNX family transcription factor 2 affects expression ISO Camphor analog affects the expression of RUNX2 mRNA CTD PMID:24704097 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Sparc secreted protein acidic and cysteine rich affects expression ISO Camphor analog affects the expression of SPARC mRNA CTD PMID:24704097 NCBI chr10:40,742,390...40,764,232
Ensembl chr10:40,742,400...40,764,185
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP Lidocaine promotes the reaction [Camphor results in increased activity of TRPV1 protein] CTD PMID:18172555 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 increases activity
multiple interactions
ISO Camphor results in increased activity of TRPV3 protein
isopentenyl pyrophosphate inhibits the reaction [Camphor results in increased activity of TRPV3 protein]
CTD PMID:21353389 NCBI chr10:59,829,755...59,863,780
Ensembl chr10:59,831,241...59,860,987
JBrowse link
cyclohexanone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Glud1 glutamate dehydrogenase 1 multiple interactions ISO
EXP
cyclohexanone promotes the reaction [2-dichlorobenzene results in increased activity of GLUD1 protein] CTD PMID:2554539 NCBI chr16:10,661,486...10,695,557
Ensembl chr16:10,662,021...10,695,557
JBrowse link
G Pgr progesterone receptor multiple interactions ISO cyclohexanone binds to and results in decreased activity of PGR protein CTD PMID:27633901 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
cyclohexanones term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC686683 similar to olfactory receptor 73 multiple interactions ISO Cyclohexanones binds to and results in increased activity of OLFR73 protein CTD PMID:21142015 NCBI chr 3:76,186,104...76,187,045
Ensembl chr 3:76,186,104...76,187,045
JBrowse link
cyclopentanone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c2 aldo-keto reductase family 1, member C2 multiple interactions
increases reduction
ISO [AKR1C2 protein co-treated with NADP] results in increased reduction of cyclopentanone; NADP promotes the reaction [AKR1C2 protein results in increased reduction of cyclopentanone]; Ursodeoxycholic Acid inhibits the reaction [[AKR1C2 protein co-treated with NADP] results in increased reduction of cyclopentanone] CTD PMID:23261716 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 multiple interactions
increases reduction
ISO [AKR1C3 protein co-treated with NADP] results in increased reduction of cyclopentanone; Medroxyprogesterone Acetate inhibits the reaction [[AKR1C3 protein co-treated with NADP] results in increased reduction of cyclopentanone]; NADP promotes the reaction [AKR1C3 protein results in increased reduction of cyclopentanone] CTD PMID:23261716 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
diphenylcyclopropenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin increases expression ISO diphenylcyclopropenone results in increased expression of ADM mRNA CTD PMID:25236440 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
JBrowse link
G Ankrd37 ankyrin repeat domain 37 increases expression ISO diphenylcyclopropenone results in increased expression of ANKRD37 mRNA CTD PMID:25236440 NCBI chr16:49,463,016...49,465,905
Ensembl chr16:49,462,889...49,465,888
JBrowse link
G Cdk12 cyclin-dependent kinase 12 decreases expression ISO diphenylcyclopropenone results in decreased expression of CDK12 mRNA CTD PMID:25236440 NCBI chr10:86,157,186...86,210,657
Ensembl chr10:86,157,608...86,222,707
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta decreases expression ISO diphenylcyclopropenone results in decreased expression of DNMT3B mRNA CTD PMID:25236440 NCBI chr 3:149,131,541...149,170,061
Ensembl chr 3:149,131,785...149,208,786
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO diphenylcyclopropenone results in increased expression of FOS mRNA CTD PMID:25236440 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO diphenylcyclopropenone results in increased expression of FOSL1 mRNA CTD PMID:25236440 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO diphenylcyclopropenone results in increased expression of HMOX1 mRNA CTD PMID:20491607 PMID:25236440 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO diphenylcyclopropenone results in increased expression of MAFF mRNA CTD PMID:20491607 NCBI chr 7:120,580,743...120,592,095
Ensembl chr 7:120,580,743...120,592,095
JBrowse link
G Mt1 metallothionein 1 increases expression ISO diphenylcyclopropenone results in increased expression of MT1A mRNA CTD PMID:20491607 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt2A metallothionein 2A increases expression ISO diphenylcyclopropenone results in increased expression of MT2A mRNA CTD PMID:20491607 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Rbm5 RNA binding motif protein 5 decreases expression ISO diphenylcyclopropenone results in decreased expression of RBM5 mRNA CTD PMID:25236440 NCBI chr 8:116,502,941...116,532,178
Ensembl chr 8:116,502,937...116,532,169
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO diphenylcyclopropenone results in increased expression of SRXN1 mRNA CTD PMID:25236440 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link
G Stc2 stanniocalcin 2 decreases expression ISO diphenylcyclopropenone results in decreased expression of STC2 mRNA CTD PMID:25236440 NCBI chr10:16,542,909...16,552,675
Ensembl chr10:16,542,882...16,553,295
JBrowse link
G Txn1 thioredoxin 1 increases expression ISO diphenylcyclopropenone results in increased expression of TXN mRNA CTD PMID:20491607 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
fenchone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO fenchone binds to and results in decreased activity of NR3C1 protein CTD PMID:27633901 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO fenchone binds to and results in decreased activity of PPARG protein CTD PMID:27633901 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
glycyrrhetinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 mRNA] CTD PMID:28549656 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Glycyrrhetinic Acid inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin] CTD PMID:16904803 PMID:24380838 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB4 mRNA] CTD PMID:28549656 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCC1 mRNA] CTD PMID:28549656 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions EXP Glycyrrhetinic Acid inhibits the reaction [ABCC2 protein results in increased transport of estradiol-17 beta-glucuronide] CTD PMID:18436619 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO 18alpha-glycyrrhetinic acid affects the reaction [1-Naphthylisothiocyanate affects the expression of ABCC3 mRNA] CTD PMID:28549656 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Glycyrrhetinic Acid inhibits the reaction [ABCG2 protein results in increased transport of estradiol-17 beta-glucuronide] CTD PMID:18436619 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCG5 mRNA] CTD PMID:28549656 NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207
JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 multiple interactions ISO 18alpha-glycyrrhetinic acid affects the reaction [1-Naphthylisothiocyanate affects the expression of ACAT2 mRNA] CTD PMID:28549656 NCBI chr 1:47,972,399...47,992,654
Ensembl chr 1:47,972,399...47,992,653
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP 18alpha-glycyrrhetinic acid inhibits the reaction [Monocrotaline results in increased expression of ACTA2 protein] CTD PMID:31325423 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity ISO Glycyrrhetinic Acid results in decreased activity of AKR1C4 protein CTD PMID:12604236 NCBI chr17:69,441,253...69,460,334
Ensembl chr17:69,441,223...69,460,321
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Glycyrrhetinic Acid results in decreased activity of AKR1C2 protein CTD PMID:12604236 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 affects activity
decreases activity
ISO 18alpha-glycyrrhetinic acid affects the activity of AKR1C3 protein
Glycyrrhetinic Acid results in decreased activity of AKR1C3 protein
CTD PMID:11165023 PMID:12604236 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Alb albumin multiple interactions ISO ALB protein binds to and affects the transport of Glycyrrhetinic Acid CTD PMID:8831264 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased activity of ALPL protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of ALPL mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [RUNX2 protein results in increased expression of ALPL mRNA] CTD PMID:21910061 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Atp8b1 ATPase phospholipid transporting 8B1 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ATP8B1 mRNA] CTD PMID:28549656 NCBI chr18:60,013,388...60,152,920
Ensembl chr18:60,013,382...60,095,354
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in increased expression of BAX protein]
18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in decreased expression of BAX protein]
CTD PMID:28414158 PMID:31325423 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in decreased expression of BCL2 protein]
18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of BCL2 protein]
CTD PMID:28414158 PMID:31325423 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased activity of BGLAP protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of BGLAP mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [RUNX2 protein results in increased expression of BGLAP mRNA] CTD PMID:21910061 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased activity of ALPL protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased activity of BGLAP protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased activity of RUNX2 protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of ALPL mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of BGLAP mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of COL1A1 mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of SP7 mRNA] CTD PMID:21910061 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318
JBrowse link
G Cat catalase multiple interactions ISO Glycyrrhetinic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of CAT mRNA] CTD PMID:23341968 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in decreased expression of CDKN1B protein] CTD PMID:31325423 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of COL1A1 mRNA] CTD PMID:21910061 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Glycyrrhetinic Acid promotes the reaction [Hydrocortisone inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]] CTD PMID:10460758 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP [brucine co-treated with Glycyrrhetinic Acid] results in decreased activity of CYP1A2 protein CTD PMID:21800547 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP [brucine co-treated with Glycyrrhetinic Acid] results in decreased activity of CYP2E1 protein CTD PMID:21800547 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 mRNA] CTD PMID:28549656 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [Cadmium Chloride results in increased expression of ERN1 protein] CTD PMID:29444456 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions EXP 18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in increased activity of GGT1 protein] CTD PMID:28414158 NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in increased activity of GPT protein]
18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased activity of GPT protein]
CTD PMID:28414158 PMID:28549656 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions ISO Glycyrrhetinic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of GPX2 mRNA] CTD PMID:23341968 NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP 18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in decreased expression of HMOX1 mRNA] CTD PMID:28414158 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hras HRas proto-oncogene, GTPase decreases expression ISO Glycyrrhetinic Acid results in decreased expression of HRAS protein CTD PMID:19958823 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases activity ISO 18alpha-glycyrrhetinic acid results in decreased activity of HSD11B1 protein CTD PMID:24135201 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity
multiple interactions
ISO 18alpha-glycyrrhetinic acid results in decreased activity of HSD11B2 protein
Glycyrrhetinic Acid inhibits the reaction [tributyltin results in increased activity of HSD11B2 protein]; Glycyrrhetinic Acid inhibits the reaction [triphenyltin chloride results in increased activity of HSD11B2 protein]
CTD PMID:24135201 PMID:31927052 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions ISO [Glycyrrhetinic Acid co-treated with NADP] binds to HSD3B1 protein CTD PMID:25526675
G Il1b interleukin 1 beta multiple interactions ISO
EXP
Glycyrrhetinic Acid promotes the reaction [Hydrocortisone inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]]
Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B mRNA]
18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in increased expression of IL1B protein]
CTD PMID:10460758 PMID:23373965 PMID:28414158 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA] CTD PMID:21644799 PMID:23373965 PMID:24849676 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO Glycyrrhetinic Acid inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] promotes the reaction [TRAF6 protein binds to IRAK1 protein]] CTD PMID:28213090 NCBI chr  X:156,716,469...156,726,367
Ensembl chr  X:156,716,604...156,725,977
JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 multiple interactions
increases expression
ISO [Glycyrrhetinic Acid co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IRAK3 mRNA; IRAK3 protein promotes the reaction [Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]]
Glycyrrhetinic Acid results in increased expression of IRAK3 protein
CTD PMID:28213090 NCBI chr 7:64,922,830...64,982,224
Ensembl chr 7:64,923,615...64,982,281
JBrowse link
G Ly96 lymphocyte antigen 96 multiple interactions ISO Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of [TLR4 protein binds to LY96 protein]] CTD PMID:28213090 NCBI chr 5:1,972,212...1,989,448 JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [Cadmium Chloride results in increased expression of MAP3K5 protein] CTD PMID:29444456 NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK1 protein] CTD PMID:23373965 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK3 protein] CTD PMID:23373965 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased activity of MMP9 protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA] CTD PMID:24613819 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of MTTP mRNA] CTD PMID:28549656 NCBI chr 2:243,366,181...243,407,608
Ensembl chr 2:243,366,181...243,407,608
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases expression
ISO
EXP
[Glycyrrhetinic Acid results in increased expression of NFE2L2] which results in decreased susceptibility to Carbon Tetrachloride; Glycyrrhetinic Acid inhibits the reaction [Carbon Tetrachloride affects the localization of NFE2L2 protein]
18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in decreased expression of NFE2L2 mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in decreased expression of NFE2L2 protein]
CTD PMID:23341968 PMID:28414158 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in decreased expression of NFKB1 protein] CTD PMID:24613819 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
Glycyrrhetinic Acid inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in increased phosphorylation of NFKBIA protein]; Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of and affects the localization of NFKBIA protein]
CTD PMID:23373965 PMID:24613819 PMID:28213090 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein] CTD PMID:21644799 PMID:23373965 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of NPC1L1 mRNA] CTD PMID:28549656 NCBI chr14:86,345,946...86,560,694
Ensembl chr14:86,345,953...86,560,694
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions EXP glycyrrhetinic acid inhibits the reaction [1-naphthyl isothiocyanate decreases expression of Nr1h4 mRNA in liver] RGD PMID:30061734 RGD:15092071 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in decreased expression of BAX protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in decreased expression of CDKN1B protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of BCL2 protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of RHOA mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of RHOA protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of ROCK1 mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of ROCK1 protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of ROCK2 mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of ROCK2 protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased phosphorylation of PPP1R12A protein] CTD PMID:31325423 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta decreases activity ISO 18alpha-glycyrrhetinic acid results in decreased activity of PIK3CD protein CTD PMID:21644799 NCBI chr 5:166,602,053...166,628,028
Ensembl chr 5:166,602,053...166,628,028
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma decreases activity ISO 18alpha-glycyrrhetinic acid results in decreased activity of PIK3CG protein CTD PMID:21644799 NCBI chr 6:51,465,696...51,501,234
Ensembl chr 6:51,465,908...51,498,337
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP 18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in decreased expression of PPARG mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in decreased expression of PPARG protein] CTD PMID:28414158 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased phosphorylation of PPP1R12A protein] CTD PMID:31325423 NCBI chr 7:51,404,971...51,515,382
Ensembl chr 7:51,404,919...51,515,373
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein] CTD PMID:21644799 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in decreased expression of RELA protein]
Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of RELA protein]
CTD PMID:23373965 PMID:24613819 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ren renin decreases activity ISO Glycyrrhetinic Acid results in decreased activity of REN protein CTD PMID:20460744 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of RHOA mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of RHOA protein] CTD PMID:31325423 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of ROCK1 mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of ROCK1 protein] CTD PMID:31325423 NCBI chr18:1,273,490...1,390,790
Ensembl chr18:1,273,453...1,390,190
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of ROCK2 mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of ROCK2 protein] CTD PMID:31325423 NCBI chr 6:42,180,864...42,289,910
Ensembl chr 6:42,180,894...42,289,908
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased activity of RUNX2 protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [RUNX2 protein results in increased expression of ALPL mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [RUNX2 protein results in increased expression of BGLAP mRNA] CTD PMID:21910061 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Slc51b solute carrier family 51 subunit beta multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of SLC51B mRNA] CTD PMID:28549656 NCBI chr 8:70,930,196...70,938,559
Ensembl chr 8:70,930,347...70,932,986
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of SLCO1A4 mRNA] CTD PMID:28549656 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions ISO Glycyrrhetinic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of SOD3 mRNA] CTD PMID:23341968 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
JBrowse link
G Sp7 Sp7 transcription factor multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of SP7 mRNA] CTD PMID:21910061 NCBI chr 7:143,957,316...143,967,488
Ensembl chr 7:143,958,858...143,967,484
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of [TLR4 protein binds to LY96 protein]] CTD PMID:28213090 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
18alpha-glycyrrhetinic acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; Glycyrrhetinic Acid inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in increased expression of and results in increased secretion of TNF protein]; Glycyrrhetinic Acid inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in increased expression of TNF mRNA]; Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; IRAK3 protein promotes the reaction [Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]]
18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in increased expression of TNF protein]
18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in decreased expression of NFKB1 protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in decreased expression of RELA protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased activity of MMP9 protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of VEGFA protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
CTD PMID:21644799 PMID:24613819 PMID:28213090 PMID:28414158 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO Glycyrrhetinic Acid inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] promotes the reaction [TRAF6 protein binds to IRAK1 protein]] CTD PMID:28213090 NCBI chr 3:91,252,829...91,271,607
Ensembl chr 3:91,252,829...91,271,607
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of VEGFA protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA] CTD PMID:24613819 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [Cadmium Chloride results in increased expression of XBP1 protein alternative form] CTD PMID:29444456 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
hyperforin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
multiple interactions
ISO hyperforin results in increased expression of ABCB1; hyperforin results in increased expression of ABCB1 mRNA
hyperforin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]
CTD PMID:15266218 PMID:16005588 PMID:24259679 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 increases expression ISO hyperforin results in increased expression of ALAS1 mRNA CTD PMID:24259679 NCBI chr 8:114,927,704...114,941,038
Ensembl chr 8:114,927,722...114,940,177
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO hyperforin results in increased expression of BAK1 protein CTD PMID:32485087 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
increases expression
multiple interactions
EXP
ISO
hyperforin results in decreased expression of BAX mRNA
hyperforin results in increased expression of BAX protein
hyperforin inhibits the reaction [aluminum maltolate results in increased expression of BAX mRNA]
CTD PMID:30481499 PMID:32485087 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
ISO
EXP
hyperforin inhibits the reaction [aluminum maltolate results in decreased expression of BCL2 mRNA]
hyperforin results in increased expression of BCL2 mRNA
CTD PMID:30481499 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
decreases expression
ISO
EXP
hyperforin inhibits the reaction [aluminum maltolate results in increased activity of CASP3 protein]; hyperforin inhibits the reaction [aluminum maltolate results in increased expression of CASP3 mRNA]
hyperforin results in increased cleavage of CASP3 protein
hyperforin results in decreased expression of CASP3 mRNA
CTD PMID:30481499 PMID:32485087 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases cleavage ISO hyperforin results in increased cleavage of CASP8 protein CTD PMID:32485087 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO hyperforin results in decreased expression of CCND1 protein CTD PMID:32485087 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression ISO hyperforin results in decreased expression of CFLAR protein CTD PMID:32485087 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Cycs cytochrome c, somatic multiple interactions
decreases expression
EXP
ISO
hyperforin inhibits the reaction [aluminum maltolate results in increased expression of CYCS protein]
hyperforin results in decreased expression of CYCS protein
CTD PMID:30481499 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
ISO hyperforin inhibits the reaction [CYP1A1 protein affects the metabolism of benzo(a)pyrene 7,8-dihydrodiol]
hyperforin results in decreased activity of CYP1A1 protein
CTD PMID:14633740 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 increases expression ISO hyperforin results in increased expression of CYP24A1 mRNA CTD PMID:15630458 NCBI chr 3:168,097,484...168,111,920
Ensembl chr 3:168,097,485...168,111,920
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO hyperforin results in increased expression of CYP2B6 mRNA CTD PMID:24259679 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity
increases expression
multiple interactions
ISO hyperforin results in decreased activity of CYP3A4 protein
hyperforin results in increased expression of CYP3A4; hyperforin results in increased expression of CYP3A4 mRNA
hyperforin results in increased expression of and results in increased activity of CYP3A4 protein
CTD PMID:15100173 PMID:15266218 PMID:16005588 PMID:16442130 PMID:17954527 PMID:24259679 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases expression ISO hyperforin results in increased expression of CYP3A5 mRNA CTD PMID:24259679 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO hyperforin results in decreased expression of CYP7A1 mRNA CTD PMID:24259679 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Egfr epidermal growth factor receptor decreases phosphorylation ISO hyperforin results in decreased phosphorylation of EGFR protein CTD PMID:32485087 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO hyperforin results in increased expression of FAS protein CTD PMID:32485087 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand increases expression ISO hyperforin results in increased expression of FASLG protein CTD PMID:32485087 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO hyperforin results in increased expression of ICAM1 mRNA CTD PMID:15622447 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO hyperforin promotes the reaction [JUN protein binds to CXCL8 promoter] CTD PMID:15622447 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
decreases phosphorylation
ISO hyperforin results in increased phosphorylation of MAPK1 protein
hyperforin results in decreased phosphorylation of MAPK1 protein
CTD PMID:15622447 PMID:32485087 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
decreases phosphorylation
ISO hyperforin results in increased phosphorylation of MAPK3 protein
hyperforin results in decreased phosphorylation of MAPK3 protein
CTD PMID:15622447 PMID:32485087 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO hyperforin results in decreased expression of MCL1 protein CTD PMID:32485087 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases response to substance
affects binding
increases activity
ISO [NR1I2 protein co-treated with hyperforin] results in decreased expression of SLC22A1 mRNA; [NR1I2 protein results in increased susceptibility to hyperforin] which results in decreased expression of SLC22A1 mRNA; hyperforin binds to and results in increased activity of NR1I2 protein; hyperforin promotes the reaction [NR1I2 protein results in decreased expression of SLC22A1 mRNA]; NR1I2 protein affects the reaction [hyperforin results in increased expression of CYP2C9 mRNA]; NR1I2 protein promotes the reaction [hyperforin results in increased abundance of Lipids]
hyperforin binds to NR1I2 protein
hyperforin results in increased activity of NR1I2 protein
CTD PMID:14600250 PMID:15630458 PMID:15856409 PMID:20079722 PMID:26187274 PMID:26920453 PMID:27071811 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Por cytochrome p450 oxidoreductase increases expression ISO hyperforin results in increased expression of POR mRNA CTD PMID:24259679 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases expression
multiple interactions
ISO hyperforin results in decreased expression of SLC22A1 protein
[NR1I2 protein co-treated with hyperforin] results in decreased expression of SLC22A1 mRNA; [NR1I2 protein results in increased susceptibility to hyperforin] which results in decreased expression of SLC22A1 mRNA; hyperforin promotes the reaction [NR1I2 protein results in decreased expression of SLC22A1 mRNA]
CTD PMID:26920453 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO hyperforin results in increased expression of UGT1A1 mRNA CTD PMID:24259679 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO hyperforin results in decreased expression of XIAP protein CTD PMID:32485087 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
irofulven term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ercc6 ERCC excision repair 6, chromatin remodeling factor increases response to substance ISO ERCC6 mutant form results in increased susceptibility to irofulven CTD PMID:28076683 NCBI chr16:8,734,028...8,804,610
Ensembl chr16:8,734,035...8,804,610
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity ISO irofulven results in decreased activity of GSR protein CTD PMID:19668867 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
ketamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression EXP Ketamine results in increased expression of ABCA1 mRNA CTD PMID:20080153 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO ABCB1A protein affects the susceptibility to [Pentobarbital co-treated with Ketamine] CTD PMID:17959987 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 increases expression EXP Ketamine results in increased expression of ABCG1 mRNA CTD PMID:20080153 NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489
JBrowse link
G Abhd16a abhydrolase domain containing 16A, phospholipase increases expression EXP Ketamine results in increased expression of ABHD16A mRNA CTD PMID:20080153 NCBI chr20:5,080,070...5,094,935
Ensembl chr20:5,080,070...5,094,935
JBrowse link
G Abhd5 abhydrolase domain containing 5, lysophosphatidic acid acyltransferase decreases expression EXP Ketamine results in decreased expression of ABHD5 mRNA CTD PMID:20080153 NCBI chr 8:130,973,222...131,001,448
Ensembl chr 8:130,973,201...131,001,458
JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 decreases expression EXP Ketamine results in decreased expression of ACAT2 mRNA CTD PMID:20080153 NCBI chr 1:47,972,399...47,992,654
Ensembl chr 1:47,972,399...47,992,653
JBrowse link
G Acbd3 acyl-CoA binding domain containing 3 decreases expression EXP Ketamine results in decreased expression of ACBD3 mRNA CTD PMID:20080153 NCBI chr13:99,004,942...99,035,520
Ensembl chr13:99,004,942...99,035,519
JBrowse link
G Acbd5 acyl-CoA binding domain containing 5 decreases expression EXP Ketamine results in decreased expression of ACBD5 mRNA CTD PMID:20080153 NCBI chr17:89,882,465...89,923,982
Ensembl chr17:89,883,615...89,923,423
JBrowse link
G Ace angiotensin I converting enzyme increases expression EXP Ketamine results in increased expression of ACE mRNA CTD PMID:20080153 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Acp6 acid phosphatase 6, lysophosphatidic decreases expression EXP Ketamine results in decreased expression of ACP6 mRNA CTD PMID:20080153 NCBI chr 2:199,284,177...199,305,793
Ensembl chr 2:199,283,909...199,305,799
JBrowse link
G Acr acrosin increases expression EXP Ketamine results in increased expression of ACR mRNA CTD PMID:20080153 NCBI chr 7:130,541,320...130,548,356
Ensembl chr 7:130,542,202...130,548,356
JBrowse link
G Acsbg1 acyl-CoA synthetase bubblegum family member 1 increases expression EXP Ketamine results in increased expression of ACSBG1 mRNA CTD PMID:20080153 NCBI chr 8:59,184,111...59,240,133
Ensembl chr 8:59,184,113...59,239,954
JBrowse link
G Actg2 actin gamma 2, smooth muscle decreases expression EXP Ketamine results in decreased expression of ACTG2 mRNA CTD PMID:20080153 NCBI chr 4:115,215,160...115,239,746
Ensembl chr 4:115,215,060...115,239,723
JBrowse link
G Acvr1c activin A receptor type 1C decreases expression EXP Ketamine results in decreased expression of ACVR1C mRNA CTD PMID:20080153 NCBI chr 3:44,272,859...44,342,501
Ensembl chr 3:44,270,653...44,342,355
JBrowse link
G Adap2 ArfGAP with dual PH domains 2 increases expression EXP Ketamine results in increased expression of ADAP2 mRNA CTD PMID:20080153 NCBI chr10:67,494,851...67,527,582
Ensembl chr10:67,494,984...67,526,426
JBrowse link
G Adck2 aarF domain containing kinase 2 decreases expression EXP Ketamine results in decreased expression of ADCK2 mRNA CTD PMID:20080153 NCBI chr 4:67,359,531...67,373,390
Ensembl chr 4:67,359,531...67,372,416
JBrowse link
G Adcy8 adenylate cyclase 8 decreases expression EXP Ketamine results in decreased expression of ADCY8 mRNA CTD PMID:20080153 NCBI chr 7:105,353,883...105,593,372
Ensembl chr 7:105,353,913...105,592,804
JBrowse link
G Adcy9 adenylate cyclase 9 increases expression EXP Ketamine results in increased expression of ADCY9 mRNA CTD PMID:20080153 NCBI chr10:11,392,698...11,515,406
Ensembl chr10:11,392,625...11,512,600
JBrowse link
G Adcyap1 adenylate cyclase activating polypeptide 1 decreases expression EXP Ketamine results in decreased expression of ADCYAP1 mRNA CTD PMID:20080153 NCBI chr 9:121,705,897...121,725,736
Ensembl chr 9:121,706,979...121,725,716
JBrowse link
G Add2 adducin 2 decreases expression EXP Ketamine results in decreased expression of ADD2 mRNA CTD PMID:20080153 NCBI chr 4:117,691,294...117,887,556
Ensembl chr 4:117,743,710...117,882,464
JBrowse link
G Adgrb2 adhesion G protein-coupled receptor B2 increases expression EXP Ketamine results in increased expression of ADGRB2 mRNA CTD PMID:20080153 NCBI chr 5:148,168,530...148,231,587
Ensembl chr 5:148,193,710...148,231,587
JBrowse link
G Afp alpha-fetoprotein increases expression EXP Ketamine results in increased expression of AFP mRNA CTD PMID:20080153 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Agt angiotensinogen decreases expression
increases expression
ISO
EXP
Ketamine results in decreased expression of AGT protein
Ketamine results in increased expression of AGT mRNA
CTD PMID:6349867 PMID:20080153 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Agtrap angiotensin II receptor-associated protein increases expression EXP Ketamine results in increased expression of AGTRAP mRNA CTD PMID:20080153 NCBI chr 5:164,888,069...164,898,387
Ensembl chr 5:164,886,813...164,898,420
JBrowse link
G Ahr aryl hydrocarbon receptor decreases expression EXP Ketamine results in decreased expression of AHR mRNA CTD PMID:20080153 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akap9 A-kinase anchoring protein 9 decreases expression EXP Ketamine results in decreased expression of AKAP9 mRNA CTD PMID:20080153 NCBI chr 4:27,195,346...27,331,582
Ensembl chr 4:27,195,346...27,331,582
JBrowse link
G Alb albumin increases expression EXP Ketamine results in increased expression of ALB mRNA CTD PMID:20080153 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aldh18a1 aldehyde dehydrogenase 18 family, member A1 decreases expression EXP Ketamine results in decreased expression of ALDH18A1 mRNA CTD PMID:20080153 NCBI chr 1:259,641,673...259,674,521
Ensembl chr 1:259,641,676...259,674,425
Ensembl chr 1:259,641,676...259,674,425
JBrowse link
G Aldoc aldolase, fructose-bisphosphate C increases expression EXP Ketamine results in increased expression of ALDOC mRNA CTD PMID:20080153 NCBI chr10:65,586,504...65,590,093
Ensembl chr10:65,586,504...65,590,126
JBrowse link
G Alms1 ALMS1, centrosome and basal body associated protein decreases expression EXP Ketamine results in decreased expression of ALMS1 mRNA CTD PMID:20080153 NCBI chr 4:117,371,544...117,472,310
Ensembl chr 4:117,371,659...117,472,198
JBrowse link
G Amigo2 adhesion molecule with Ig like domain 2 decreases expression EXP Ketamine results in decreased expression of AMIGO2 mRNA CTD PMID:20080153 NCBI chr 7:138,704,124...138,707,221
Ensembl chr 7:138,704,126...138,707,221
JBrowse link
G Anapc1 anaphase promoting complex subunit 1 increases expression EXP Ketamine results in increased expression of ANAPC1 mRNA CTD PMID:20080153 NCBI chr 3:121,147,484...121,226,125
Ensembl chr 3:121,147,547...121,226,125
JBrowse link
G Angptl4 angiopoietin-like 4 increases expression EXP Ketamine results in increased expression of ANGPTL4 mRNA CTD PMID:20080153 NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079
JBrowse link
G Ankrd42 ankyrin repeat domain 42 decreases expression EXP Ketamine results in decreased expression of ANKRD42 mRNA CTD PMID:20080153 NCBI chr 1:157,419,117...157,461,588
Ensembl chr 1:157,419,123...157,461,588
JBrowse link
G Anxa11 annexin A11 increases expression EXP Ketamine results in increased expression of ANXA11 mRNA CTD PMID:20080153 NCBI chr16:3,867,193...3,912,043
Ensembl chr16:3,867,208...3,912,148
JBrowse link
G Anxa3 annexin A3 decreases expression EXP Ketamine results in decreased expression of ANXA3 mRNA CTD PMID:20080153 NCBI chr14:14,371,921...14,426,503
Ensembl chr14:14,364,008...14,426,437
JBrowse link
G Anxa4 annexin A4 increases expression EXP Ketamine results in increased expression of ANXA4 mRNA CTD PMID:20080153 NCBI chr 4:118,538,775...118,595,591
Ensembl chr 4:118,538,777...118,595,580
JBrowse link
G Anxa5 annexin A5 decreases expression EXP Ketamine results in decreased expression of ANXA5 mRNA CTD PMID:20080153 NCBI chr 2:123,162,477...123,194,730
Ensembl chr 2:123,162,461...123,193,130
JBrowse link
G Ap2m1 adaptor related protein complex 2 subunit mu 1 multiple interactions ISO Ketamine inhibits the reaction [NTRK2 protein binds to AP2M1 protein] CTD PMID:31631060 NCBI chr11:84,041,184...84,047,542
Ensembl chr11:84,041,184...84,047,546
JBrowse link
G Ap3m1 adaptor related protein complex 3 subunit mu 1 decreases expression EXP Ketamine results in decreased expression of AP3M1 mRNA CTD PMID:20080153 NCBI chr15:3,435,998...3,454,281
Ensembl chr15:3,436,361...3,454,279
JBrowse link
G Ap5m1 adaptor related protein complex 5 subunit mu 1 decreases expression EXP Ketamine results in decreased expression of AP5M1 mRNA CTD PMID:20080153 NCBI chr15:25,933,483...25,955,745
Ensembl chr15:25,933,483...25,955,745
JBrowse link
G Apex2 apurinic/apyrimidinic endodeoxyribonuclease 2 decreases expression EXP Ketamine results in decreased expression of APEX2 mRNA CTD PMID:20080153 NCBI chr  X:23,146,085...23,166,676
Ensembl chr  X:23,146,085...23,166,675
JBrowse link
G Aplf aprataxin and PNKP like factor decreases expression EXP Ketamine results in decreased expression of APLF mRNA CTD PMID:20080153 NCBI chr 4:119,514,822...119,568,764
Ensembl chr 4:119,514,840...119,568,736
JBrowse link
G Apmap adipocyte plasma membrane associated protein increases expression EXP Ketamine results in increased expression of APMAP mRNA CTD PMID:20080153 NCBI chr 3:146,376,828...146,407,259
Ensembl chr 3:146,376,828...146,407,252
JBrowse link
G Apoe apolipoprotein E decreases response to substance
increases expression
ISO
EXP
APOE results in decreased susceptibility to Ketamine
Ketamine results in increased expression of APOE mRNA
CTD PMID:9778666 PMID:20080153 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Appbp2 amyloid beta precursor protein binding protein 2 decreases expression EXP Ketamine results in decreased expression of APPBP2 mRNA CTD PMID:20080153 NCBI chr10:72,503,347...72,545,141
Ensembl chr10:72,503,347...72,545,141
JBrowse link
G Arfgef1 ADP ribosylation factor guanine nucleotide exchange factor 1 decreases expression EXP Ketamine results in decreased expression of ARFGEF1 mRNA CTD PMID:20080153 NCBI chr 5:8,666,046...8,760,458
Ensembl chr 5:8,666,200...8,760,458
JBrowse link
G Arhgap5 Rho GTPase activating protein 5 decreases expression EXP Ketamine results in decreased expression of ARHGAP5 mRNA CTD PMID:20080153 NCBI chr 6:73,345,129...73,408,304
Ensembl chr 6:73,345,392...73,405,880
JBrowse link
G Arih1 ariadne RBR E3 ubiquitin protein ligase 1 decreases expression EXP Ketamine results in decreased expression of ARIH1 mRNA CTD PMID:20080153 NCBI chr 8:64,166,359...64,268,555
Ensembl chr 8:64,166,360...64,268,555
JBrowse link
G Arl6 ADP-ribosylation factor like GTPase 6 decreases expression EXP Ketamine results in decreased expression of ARL6 mRNA CTD PMID:20080153 NCBI chr11:42,858,476...42,884,324
Ensembl chr11:42,858,478...42,884,603
JBrowse link
G Arl6ip6 ADP ribosylation factor like GTPase 6 interacting protein 6 decreases expression EXP Ketamine results in decreased expression of ARL6IP6 mRNA CTD PMID:20080153 NCBI chr 3:38,742,072...38,768,010
Ensembl chr 3:38,742,072...38,768,008
JBrowse link
G Armc10 armadillo repeat containing 10 decreases expression EXP Ketamine results in decreased expression of ARMC10 mRNA CTD PMID:20080153 NCBI chr 4:10,004,846...10,020,017
Ensembl chr 4:10,004,848...10,020,022
JBrowse link
G Art3 ADP-ribosyltransferase 3 increases expression EXP Ketamine results in increased expression of ART3 mRNA CTD PMID:20080153 NCBI chr14:17,143,037...17,225,389
Ensembl chr14:17,143,040...17,225,389
JBrowse link
G Ascl1 achaete-scute family bHLH transcription factor 1 decreases expression EXP Ketamine results in decreased expression of ASCL1 mRNA CTD PMID:20080153 NCBI chr 7:28,038,662...28,040,504
Ensembl chr 7:28,038,662...28,040,510
JBrowse link
G Asic4 acid sensing ion channel subunit family member 4 increases expression EXP Ketamine results in increased expression of ASIC4 mRNA CTD PMID:20080153 NCBI chr 9:82,647,071...82,668,920
Ensembl chr 9:82,647,071...82,668,920
JBrowse link
G Aspdh aspartate dehydrogenase domain containing increases expression EXP Ketamine results in increased expression of ASPDH mRNA CTD PMID:20080153 NCBI chr 1:100,471,066...100,473,327
Ensembl chr 1:100,470,722...100,473,459
JBrowse link
G Atg12 autophagy related 12 increases expression EXP Ketamine results in increased expression of ATG12 mRNA CTD PMID:20080153 NCBI chr18:40,721,799...40,732,143
Ensembl chr18:40,721,800...40,732,126
JBrowse link
G Atp13a4 ATPase 13A4 increases expression EXP Ketamine results in increased expression of ATP13A4 mRNA CTD PMID:20080153 NCBI chr11:74,833,824...74,968,160
Ensembl chr11:74,834,050...74,968,336
JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 increases expression EXP Ketamine results in increased expression of ATP1A1 mRNA CTD PMID:20080153 NCBI chr 2:204,003,742...204,032,023
Ensembl chr 2:204,003,742...204,032,023
JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 increases expression EXP Ketamine results in increased expression of ATP1A2 mRNA CTD PMID:20080153 NCBI chr13:90,651,682...90,676,629
Ensembl chr13:90,651,686...90,676,629
JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 increases expression EXP Ketamine results in increased expression of ATP1A3 mRNA CTD PMID:20080153 NCBI chr 1:81,852,423...81,881,565
Ensembl chr 1:81,852,429...81,881,549
JBrowse link
G Atp6v0a1 ATPase H+ transporting V0 subunit a1 increases expression EXP Ketamine results in increased expression of ATP6V0A1 mRNA CTD PMID:20080153 NCBI chr10:88,914,264...88,967,736
Ensembl chr10:88,914,276...88,967,748
JBrowse link
G Atp6v1c2 ATPase H+ transporting V1 subunit C2 increases expression EXP Ketamine results in increased expression of ATP6V1C2 mRNA CTD PMID:20080153 NCBI chr 6:42,585,452...42,632,289
Ensembl chr 6:42,585,934...42,630,983
JBrowse link
G Atp7a ATPase copper transporting alpha decreases expression EXP Ketamine results in decreased expression of ATP7A mRNA CTD PMID:20080153 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G B4gat1 beta-1,4-glucuronyltransferase 1 increases expression EXP Ketamine results in increased expression of B4GAT1 mRNA CTD PMID:20080153 NCBI chr 1:220,322,854...220,325,076
Ensembl chr 1:220,416,018...220,418,240
JBrowse link
G Bag3 BAG cochaperone 3 increases expression EXP Ketamine results in increased expression of BAG3 mRNA CTD PMID:20080153 NCBI chr 1:199,941,258...199,965,191
Ensembl chr 1:199,941,161...199,965,191
JBrowse link
G Baiap2 BAR/IMD domain containing adaptor protein 2 increases expression EXP Ketamine results in increased expression of BAIAP2 mRNA CTD PMID:20080153 NCBI chr10:109,107,326...109,187,458
Ensembl chr10:109,107,389...109,187,115
JBrowse link
G Banp Btg3 associated nuclear protein decreases expression EXP Ketamine results in decreased expression of BANP mRNA CTD PMID:20080153 NCBI chr19:54,766,441...54,843,795
Ensembl chr19:54,766,589...54,840,569
JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects localization
increases expression
ISO
EXP
Ketamine affects the localization of BAX protein
Ketamine results in increased expression of BAX protein
CTD PMID:18456338 PMID:19001360 PMID:25937004 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bckdha branched chain keto acid dehydrogenase E1 subunit alpha increases expression EXP Ketamine results in increased expression of BCKDHA mRNA CTD PMID:20080153 NCBI chr 1:82,423,291...82,452,094
Ensembl chr 1:82,423,277...82,452,281
JBrowse link
G Bclaf3 BCLAF1 and THRAP3 family member 3 decreases expression EXP Ketamine results in decreased expression of BCLAF3 mRNA CTD PMID:20080153 NCBI chr  X:38,294,009...38,353,525
Ensembl chr  X:38,295,365...38,353,461
JBrowse link
G Bcorl1 BCL6 co-repressor-like 1 decreases expression EXP Ketamine results in decreased expression of BCORL1 mRNA CTD PMID:20080153 NCBI chr  X:135,187,468...135,233,859
Ensembl chr  X:135,187,468...135,233,839
JBrowse link
G Bcs1l BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone decreases expression EXP Ketamine results in decreased expression of BCS1L mRNA CTD PMID:20080153 NCBI chr 9:81,868,158...81,872,201
Ensembl chr 9:81,868,265...81,872,197
JBrowse link
G Bdkrb1 bradykinin receptor B1 increases expression ISO Ketamine results in increased expression of BDKRB1 mRNA; Ketamine results in increased expression of BDKRB1 protein CTD PMID:27638051 NCBI chr 6:129,437,423...129,441,553
Ensembl chr 6:129,438,158...129,440,574
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
increases expression
EXP
ISO
Ketamine inhibits the reaction [Isoflurophate results in decreased expression of BDNF protein]; Ketamine inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA]
Ketamine results in increased expression of BDNF protein
Sirolimus inhibits the reaction [Ketamine results in increased expression of BDNF protein]
CTD PMID:8635431 PMID:32592718 PMID:33022268 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Bhlhe22 basic helix-loop-helix family, member e22 decreases expression EXP Ketamine results in decreased expression of BHLHE22 mRNA CTD PMID:20080153 NCBI chr 2:102,685,513...102,688,624
Ensembl chr 2:102,685,513...102,688,624
JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 increases expression EXP Ketamine results in increased expression of BHLHE40 mRNA CTD PMID:20080153 NCBI chr 4:140,703,619...140,709,319
Ensembl chr 4:140,703,619...140,709,319
JBrowse link
G Bhlhe41 basic helix-loop-helix family, member e41 increases expression EXP Ketamine results in increased expression of BHLHE41 mRNA CTD PMID:20080153 NCBI chr 4:180,230,742...180,235,138
Ensembl chr 4:180,232,382...180,234,804
JBrowse link
G Bmi1 BMI1 proto-oncogene, polycomb ring finger decreases expression EXP Ketamine results in decreased expression of BMI1 mRNA CTD PMID:20080153 NCBI chr17:85,360,439...85,370,283
Ensembl chr17:85,364,483...85,368,208
JBrowse link
G Bnip3 BCL2 interacting protein 3 decreases expression EXP Ketamine results in decreased expression of BNIP3 mRNA CTD PMID:20080153 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase multiple interactions ISO Ketamine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of BRAF protein] CTD PMID:19540866 NCBI chr 4:67,389,331...67,520,549
Ensembl chr 4:67,396,192...67,520,356
JBrowse link
G Brinp2 BMP/retinoic acid inducible neural specific 2 increases expression EXP Ketamine results in increased expression of BRINP2 mRNA CTD PMID:20080153 NCBI chr13:75,948,679...76,049,363
Ensembl chr13:75,948,679...76,049,363
JBrowse link
G Btg1 BTG anti-proliferation factor 1 decreases expression EXP Ketamine results in decreased expression of BTG1 mRNA CTD PMID:20080153 NCBI chr 7:37,812,831...37,815,088
Ensembl chr 7:37,812,831...37,815,088
JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B decreases expression EXP Ketamine results in decreased expression of BUB1B mRNA CTD PMID:20080153 NCBI chr 3:110,367,949...110,420,471
Ensembl chr 3:110,367,939...110,420,458
JBrowse link
G C1qa complement C1q A chain increases expression EXP Ketamine results in increased expression of C1QA mRNA CTD PMID:20080153 NCBI chr 5:155,261,254...155,264,101
Ensembl chr 5:155,261,250...155,264,143
JBrowse link
G C1qb complement C1q B chain increases expression EXP Ketamine results in increased expression of C1QB mRNA CTD PMID:20080153 NCBI chr 5:155,246,444...155,251,995
Ensembl chr 5:155,246,447...155,252,003
JBrowse link
G C1qc complement C1q C chain increases expression EXP Ketamine results in increased expression of C1QC mRNA CTD PMID:20080153 NCBI chr 5:155,255,013...155,258,631
Ensembl chr 5:155,255,005...155,258,392
JBrowse link
G C2 complement C2 increases expression EXP Ketamine results in increased expression of C2 mRNA CTD PMID:20080153 NCBI chr20:4,542,340...4,561,152
Ensembl chr20:4,542,340...4,561,152
JBrowse link
G C2cd2l C2CD2-like increases expression EXP Ketamine results in increased expression of C2CD2L mRNA CTD PMID:20080153 NCBI chr 8:48,641,792...48,652,119
Ensembl chr 8:48,641,801...48,652,071
JBrowse link
G C2cd4b C2 calcium-dependent domain containing 4B increases expression EXP Ketamine results in increased expression of C2CD4B mRNA CTD PMID:20080153 NCBI chr 8:73,555,414...73,580,848
Ensembl chr 8:73,593,310...73,594,332
JBrowse link
G C4bpb complement component 4 binding protein, beta increases expression EXP Ketamine results in increased expression of C4BPB mRNA CTD PMID:20080153 NCBI chr13:47,387,173...47,398,115
Ensembl chr13:47,387,173...47,397,890
JBrowse link
G Ca4 carbonic anhydrase 4 increases expression EXP Ketamine results in increased expression of CAR4 mRNA CTD PMID:20080153 NCBI chr10:72,272,286...72,281,069
Ensembl chr10:72,272,248...72,281,067
JBrowse link
G Caap1 caspase activity and apoptosis inhibitor 1 decreases expression EXP Ketamine results in decreased expression of CAAP1 mRNA CTD PMID:20080153 NCBI chr 5:113,479,416...113,532,961
Ensembl chr 5:113,480,547...113,532,878
JBrowse link
G Cabcoco1 ciliary associated calcium binding coiled-coil 1 increases expression EXP Ketamine results in increased expression of CABCOCO1 mRNA CTD PMID:20080153 NCBI chr20:21,316,770...21,426,036
Ensembl chr20:21,316,826...21,426,034
JBrowse link
G Cabp7 calcium binding protein 7 increases expression EXP Ketamine results in increased expression of CABP7 mRNA CTD PMID:20080153 NCBI chr14:84,968,125...84,978,242
Ensembl chr14:84,968,130...84,978,255
JBrowse link
G Cacng2 calcium voltage-gated channel auxiliary subunit gamma 2 increases expression EXP Ketamine results in increased expression of CACNG2 mRNA CTD PMID:20080153 NCBI chr 7:119,228,112...119,353,332
Ensembl chr 7:119,228,102...119,352,605
JBrowse link
G Calb2 calbindin 2 increases expression EXP Ketamine results in increased expression of CALB2 mRNA CTD PMID:20080153 NCBI chr19:41,482,743...41,509,617
Ensembl chr19:41,482,728...41,509,658
JBrowse link
G Camkk1 calcium/calmodulin-dependent protein kinase kinase 1 increases expression EXP Ketamine results in increased expression of CAMKK1 mRNA CTD PMID:20080153 NCBI chr10:59,585,023...59,608,180
Ensembl chr10:59,585,072...59,608,165
JBrowse link
G Cand2 cullin-associated and neddylation-dissociated 2 (putative) decreases expression EXP Ketamine results in decreased expression of CAND2 mRNA CTD PMID:20080153 NCBI chr 4:147,686,487...147,714,593
Ensembl chr 4:147,686,490...147,714,585
JBrowse link
G Cant1 calcium activated nucleotidase 1 increases expression EXP Ketamine results in increased expression of CANT1 mRNA CTD PMID:20080153 NCBI chr10:107,432,500...107,445,634
Ensembl chr10:107,432,506...107,445,522
JBrowse link
G Car7 carbonic anhydrase 7 increases expression EXP Ketamine results in increased expression of CAR7 mRNA CTD PMID:20080153 NCBI chr19:636,545...645,935
Ensembl chr19:636,545...645,937
JBrowse link
G Casp3 caspase 3 increases activity
increases expression
ISO
EXP
Ketamine results in increased activity of CASP3 protein
Ketamine results in increased expression of CASP3 protein modified form
CTD PMID:17920787 PMID:19001360 PMID:25937004 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp6 caspase 6 increases activity ISO Ketamine results in increased activity of CASP6 protein CTD PMID:19001360 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Casp9 caspase 9 increases activity
increases expression
ISO
EXP
Ketamine results in increased activity of CASP9 protein
Ketamine results in increased expression of CASP9 mRNA
CTD PMID:19001360 PMID:20080153 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cbr3 carbonyl reductase 3 decreases expression EXP Ketamine results in decreased expression of CBR3 mRNA CTD PMID:20080153 NCBI chr11:33,909,417...33,917,674
Ensembl chr11:33,909,439...33,917,674
JBrowse link
G Cbx1 chromobox 1 decreases expression EXP Ketamine results in decreased expression of CBX1 mRNA CTD PMID:20080153 NCBI chr10:84,656,698...84,677,112
Ensembl chr10:84,669,914...84,675,741
JBrowse link
G Cbx7 chromobox 7 increases expression EXP Ketamine results in increased expression of CBX7 mRNA CTD PMID:20080153 NCBI chr 7:121,136,067...121,153,503
Ensembl chr 7:121,136,058...121,153,383
JBrowse link
G Ccdc115 coiled-coil domain containing 115 increases expression EXP Ketamine results in increased expression of CCDC115 mRNA CTD PMID:20080153 NCBI chr 9:37,774,876...37,778,839
Ensembl chr 9:37,775,311...37,779,967
JBrowse link
G Ccdc50 coiled-coil domain containing 50 decreases expression EXP Ketamine results in decreased expression of CCDC50 mRNA CTD PMID:20080153 NCBI chr11:76,742,179...76,804,695
Ensembl chr11:76,747,865...76,804,510
JBrowse link
G Ccdc85a coiled-coil domain containing 85A decreases expression EXP Ketamine results in decreased expression of CCDC85A mRNA CTD PMID:20080153 NCBI chr14:112,719,482...112,900,724
Ensembl chr14:112,719,482...112,946,875
JBrowse link
G Ccdc90b coiled-coil domain containing 90B decreases expression EXP Ketamine results in decreased expression of CCDC90B mRNA CTD PMID:20080153 NCBI chr 1:157,403,595...157,417,153
Ensembl chr 1:157,403,595...157,417,147
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 protein] CTD PMID:22245128 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccna2 cyclin A2 decreases expression EXP Ketamine results in decreased expression of CCNA2 mRNA CTD PMID:20080153 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnd1 cyclin D1 decreases expression EXP Ketamine results in decreased expression of CCND1 mRNA CTD PMID:20080153 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccndbp1 cyclin D1 binding protein 1 decreases expression EXP Ketamine results in decreased expression of CCNDBP1 mRNA CTD PMID:20080153 NCBI chr 3:112,951,065...112,961,620
Ensembl chr 3:112,950,890...112,961,614
JBrowse link
G Ccpg1 cell cycle progression 1 increases expression EXP Ketamine results in increased expression of CCPG1 mRNA CTD PMID:20080153 NCBI chr 8:79,660,634...79,692,044
Ensembl chr 8:79,660,657...79,692,039
JBrowse link
G Ccr5 C-C motif chemokine receptor 5 increases expression EXP Ketamine results in increased expression of CCR5 mRNA CTD PMID:20080153 NCBI chr 8:133,192,398...133,215,599
Ensembl chr 8:133,197,032...133,215,614
JBrowse link
G Ccsap centriole, cilia and spindle-associated protein increases expression EXP Ketamine results in increased expression of CCSAP mRNA CTD PMID:20080153 NCBI chr19:56,615,326...56,634,031
Ensembl chr19:56,617,399...56,633,633
JBrowse link
G Cd24 CD24 molecule decreases expression EXP Ketamine results in decreased expression of CD24 mRNA CTD PMID:20080153 NCBI chr20:48,335,540...48,340,847
Ensembl chr20:48,335,540...48,340,846
JBrowse link
G Cd38 CD38 molecule increases expression EXP Ketamine results in increased expression of CD38 mRNA CTD PMID:20080153 NCBI chr14:71,714,768...71,754,990
Ensembl chr14:71,715,269...71,754,672
JBrowse link
G Cd83 CD83 molecule increases expression EXP Ketamine results in increased expression of CD83 mRNA CTD PMID:20080153 NCBI chr17:24,416,651...24,435,790
Ensembl chr17:24,416,651...24,435,790
JBrowse link
G Cdc42ep3 CDC42 effector protein 3 decreases expression EXP Ketamine results in decreased expression of CDC42EP3 mRNA CTD PMID:20080153 NCBI chr 6:1,922,500...1,942,972
Ensembl chr 6:1,922,500...1,942,972
JBrowse link
G Cdc6 cell division cycle 6 decreases expression EXP Ketamine results in decreased expression of CDC6 mRNA CTD PMID:20080153 NCBI chr10:86,819,477...86,833,301
Ensembl chr10:86,819,472...86,833,402
JBrowse link
G Cdca7 cell division cycle associated 7 decreases expression EXP Ketamine results in decreased expression of CDCA7 mRNA CTD PMID:20080153 NCBI chr 3:59,153,281...59,163,916
Ensembl chr 3:59,153,280...59,163,913
JBrowse link
G Cdh11 cadherin 11 decreases expression EXP Ketamine results in decreased expression of CDH11 mRNA CTD PMID:20080153 NCBI chr19:2,391,181...2,551,245
Ensembl chr19:2,393,059...2,551,245
JBrowse link
G Cdh7 cadherin 7 decreases expression EXP Ketamine results in decreased expression of CDH7 mRNA CTD PMID:20080153 NCBI chr13:31,081,064...31,228,884
Ensembl chr13:31,081,804...31,231,213
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression EXP Ketamine results in decreased expression of CDK1 mRNA CTD PMID:20080153 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk14 cyclin-dependent kinase 14 decreases expression EXP Ketamine results in decreased expression of CDK14 mRNA CTD PMID:20080153 NCBI chr 4:25,825,567...26,419,443
Ensembl chr 4:25,825,567...26,419,127
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression EXP Ketamine results in increased expression of CEBPB mRNA CTD PMID:20080153 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Cenpc centromere protein C decreases expression EXP Ketamine results in decreased expression of CENPC1 mRNA CTD PMID:20080153 NCBI chr14:23,611,909...23,670,314
Ensembl chr14:23,611,735...23,670,475
JBrowse link
G Cep70 centrosomal protein 70 decreases expression EXP Ketamine results in decreased expression of CEP70 mRNA CTD PMID:20080153 NCBI chr 8:107,495,326...107,548,274
Ensembl chr 8:107,495,366...107,548,269
JBrowse link
G Cfap126 cilia and flagella associated protein 126 increases expression EXP Ketamine results in increased expression of CFAP126 mRNA CTD PMID:20080153 NCBI chr13:89,480,058...89,495,949
Ensembl chr13:89,480,058...89,495,949
JBrowse link
G Cfap410 cilia and flagella associated protein 410 increases expression EXP Ketamine results in increased expression of CFAP410 mRNA CTD PMID:20080153 NCBI chr20:11,417,428...11,424,301
Ensembl chr20:11,417,429...11,424,324
JBrowse link
G Chi3l1 chitinase 3 like 1 increases expression EXP Ketamine results in increased expression of CHI3L1 mRNA CTD PMID:20080153 NCBI chr13:51,022,844...51,030,797
Ensembl chr13:51,022,681...51,030,802
JBrowse link
G Chordc1 cysteine and histidine rich domain containing 1 decreases expression EXP Ketamine results in decreased expression of CHORDC1 mRNA CTD PMID:20080153 NCBI chr 8:17,421,552...17,445,513
Ensembl chr 8:17,421,557...17,446,165
JBrowse link
G Chpf2 chondroitin polymerizing factor 2 increases expression EXP Ketamine results in increased expression of CHPF2 mRNA CTD PMID:20080153 NCBI chr 4:7,108,461...7,113,940
Ensembl chr 4:7,108,462...7,113,919
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions ISO Ketamine inhibits the reaction [Scopolamine Derivatives binds to CHRM1 protein] CTD PMID:12456425 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions ISO Ketamine inhibits the reaction [Scopolamine Derivatives binds to CHRM2 protein] CTD PMID:12456425 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 multiple interactions ISO Ketamine inhibits the reaction [Scopolamine Derivatives binds to CHRM3 protein] CTD PMID:12456425 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
G Ciao3 cytosolic iron-sulfur assembly component 3 increases expression EXP Ketamine results in increased expression of CIAO3 mRNA CTD PMID:20080153 NCBI chr10:15,143,732...15,152,706
Ensembl chr10:15,143,713...15,153,396
JBrowse link
G Cldn11 claudin 11 increases expression EXP Ketamine results in increased expression of CLDN11 mRNA CTD PMID:20080153 NCBI chr 2:115,823,541...115,836,846
Ensembl chr 2:115,823,538...115,836,846
JBrowse link
G Clec2l C-type lectin domain family 2, member L increases expression EXP Ketamine results in increased expression of CLEC2L mRNA CTD PMID:20080153 NCBI chr 4:66,404,880...66,421,656
Ensembl chr 4:66,405,166...66,421,654
JBrowse link
G Clk1 CDC-like kinase 1 decreases expression EXP Ketamine results in decreased expression of CLK1 mRNA CTD PMID:20080153 NCBI chr 9:65,296,777...65,308,017
Ensembl chr 9:65,296,778...65,307,995
JBrowse link
G Clmp CXADR-like membrane protein decreases expression EXP Ketamine results in decreased expression of CLMP mRNA CTD PMID:20080153 NCBI chr 8:44,846,685...44,975,460
Ensembl chr 8:44,847,157...44,975,457
JBrowse link
G Clu clusterin increases expression EXP Ketamine results in increased expression of CLU mRNA CTD PMID:20080153 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Cmtm5 CKLF-like MARVEL transmembrane domain containing 5 increases expression EXP Ketamine results in increased expression of CMTM5 mRNA CTD PMID:20080153 NCBI chr15:33,600,016...33,602,839
Ensembl chr15:33,600,102...33,602,834
JBrowse link
G Cmtm8 CKLF-like MARVEL transmembrane domain containing 8 increases expression EXP Ketamine results in increased expression of CMTM8 mRNA CTD PMID:20080153 NCBI chr 8:122,848,249...122,913,597
Ensembl chr 8:122,848,501...122,904,913
JBrowse link
G Cnksr3 Cnksr family member 3 increases expression EXP Ketamine results in increased expression of CNKSR3 mRNA CTD PMID:20080153 NCBI chr 1:43,789,797...43,884,267
Ensembl chr 1:43,789,791...43,884,267
JBrowse link
G Cnr1 cannabinoid receptor 1 decreases expression EXP Ketamine results in decreased expression of CNR1 mRNA CTD PMID:20080153 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Coa4 cytochrome c oxidase assembly factor 4 homolog decreases expression EXP Ketamine results in decreased expression of COA4 mRNA CTD PMID:20080153 NCBI chr 1:165,549,319...165,552,573
Ensembl chr 1:165,549,344...165,552,572
JBrowse link
G Coa7 cytochrome c oxidase assembly factor 7 increases expression EXP Ketamine results in increased expression of COA7 mRNA CTD PMID:20080153 NCBI chr 5:127,925,726...127,936,516
Ensembl chr 5:127,925,726...127,936,509
JBrowse link
G Cog6 component of oligomeric golgi complex 6 decreases expression EXP Ketamine results in decreased expression of COG6 mRNA CTD PMID:20080153 NCBI chr 2:142,197,566...142,235,054
Ensembl chr 2:142,196,754...142,235,066
JBrowse link
G Col11a1 collagen type XI alpha 1 chain decreases expression EXP Ketamine results in decreased expression of COL11A1 mRNA CTD PMID:20080153 NCBI chr 2:216,863,423...217,056,523
Ensembl chr 2:216,863,428...217,056,523
JBrowse link
G Commd5 COMM domain containing 5 increases expression EXP Ketamine results in increased expression of COMMD5 mRNA CTD PMID:20080153 NCBI chr 7:117,963,213...117,965,010
Ensembl chr 7:118,502,676...118,504,097
Ensembl chr 7:118,502,676...118,504,097
JBrowse link
G Comt catechol-O-methyltransferase increases expression EXP Ketamine results in increased expression of COMT mRNA CTD PMID:20080153 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Coq8a coenzyme Q8A increases expression EXP Ketamine results in increased expression of COQ8A mRNA CTD PMID:20080153 NCBI chr13:98,451,629...98,480,438
Ensembl chr13:98,451,637...98,480,419
JBrowse link
G Cort cortistatin increases expression EXP Ketamine results in increased expression of CORT mRNA CTD PMID:20080153 NCBI chr 5:165,942,780...165,944,221 JBrowse link
G Cox6a2 cytochrome c oxidase subunit 6A2 increases expression EXP Ketamine results in increased expression of COX6A2 mRNA CTD PMID:20080153 NCBI chr 1:199,624,037...199,626,255
Ensembl chr 1:199,624,037...199,624,783
JBrowse link
G Cracdl CRACD like increases expression EXP Ketamine results in increased expression of CRACDL mRNA CTD PMID:20080153 NCBI chr 9:44,194,348...44,309,816
Ensembl chr 9:44,194,325...44,237,117
JBrowse link
G Crcp CGRP receptor component increases expression EXP Ketamine results in increased expression of CRCP mRNA CTD PMID:20080153 NCBI chr12:30,125,237...30,160,857
Ensembl chr12:30,125,168...30,180,115
JBrowse link
G Creg1 cellular repressor of E1A-stimulated genes 1 increases expression EXP Ketamine results in increased expression of CREG1 mRNA CTD PMID:20080153 NCBI chr13:83,972,186...83,984,675
Ensembl chr13:83,972,212...83,984,675
JBrowse link
G Creld2 cysteine-rich with EGF-like domains 2 decreases expression EXP Ketamine results in decreased expression of CRELD2 mRNA CTD PMID:20080153 NCBI chr 7:129,812,746...129,819,641
Ensembl chr 7:129,812,789...129,819,634
JBrowse link
G Crh corticotropin releasing hormone decreases expression EXP Ketamine results in decreased expression of CRH mRNA CTD PMID:20080153 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Crls1 cardiolipin synthase 1 decreases expression EXP Ketamine results in decreased expression of CRLS1 mRNA CTD PMID:20080153 NCBI chr 3:125,503,638...125,522,460
Ensembl chr 3:125,503,638...125,522,441
JBrowse link
G Crtac1 cartilage acidic protein 1 increases expression EXP Ketamine results in increased expression of CRTAC1 mRNA CTD PMID:20080153 NCBI chr 1:261,527,009...261,669,614
Ensembl chr 1:261,514,141...261,669,586
JBrowse link
G Cryab crystallin, alpha B increases expression EXP Ketamine results in increased expression of CRYAB mRNA CTD PMID:20080153 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545
JBrowse link
G Ctse cathepsin E increases expression EXP Ketamine results in increased expression of CTSE mRNA CTD PMID:20080153 NCBI chr13:48,426,833...48,449,493
Ensembl chr13:48,426,820...48,449,490
JBrowse link
G Ctsk cathepsin K increases expression EXP Ketamine results in increased expression of CTSK mRNA CTD PMID:20080153 NCBI chr 2:196,655,469...196,666,447
Ensembl chr 2:196,655,469...196,666,446
JBrowse link
G Ctss cathepsin S increases expression EXP Ketamine results in increased expression of CTSS mRNA CTD PMID:20080153 NCBI chr 2:197,655,780...197,679,768
Ensembl chr 2:197,655,786...197,679,458
JBrowse link
G Cttnbp2nl CTTNBP2 N-terminal like decreases expression EXP Ketamine results in decreased expression of CTTNBP2NL mRNA CTD PMID:20080153 NCBI chr 2:207,495,056...207,541,808
Ensembl chr 2:207,495,055...207,541,645
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 increases expression EXP Ketamine results in increased expression of CX3CL1 mRNA CTD PMID:20080153 NCBI chr19:10,644,267...10,654,861
Ensembl chr19:10,644,244...10,653,800
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 protein] CTD PMID:22245128 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cxxc4 CXXC finger protein 4 decreases expression EXP Ketamine results in decreased expression of CXXC4 mRNA CTD PMID:20080153 NCBI chr 2:239,414,882...239,439,640
Ensembl chr 2:239,415,046...239,439,568
JBrowse link
G Cyb5r3 cytochrome b5 reductase 3 increases expression EXP Ketamine results in increased expression of CYB5R3 mRNA CTD PMID:20080153 NCBI chr 7:124,024,003...124,041,564
Ensembl chr 7:124,023,995...124,041,594
JBrowse link
G Cyba cytochrome b-245 alpha chain increases expression ISO Ketamine results in increased expression of CYBA CTD PMID:18063801 NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876
JBrowse link
G Cybb cytochrome b-245 beta chain increases expression ISO Ketamine results in increased expression of CYBB CTD PMID:18063801 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases expression EXP Ketamine results in increased expression of CYP11A1 mRNA CTD PMID:20080153 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP Ketamine results in increased expression of CYP1A1 protein CTD PMID:16076768 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP Ketamine results in increased expression of CYP2B1 protein CTD PMID:16076768 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression EXP Ketamine results in increased expression of CYP2E1 protein CTD PMID:16076768 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression EXP Ketamine results in increased expression of CYP3A2 protein CTD PMID:16076768 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Ketamine results in increased expression of CYP3A23-3A1 protein CTD PMID:16076768 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 multiple interactions
decreases expression
ISO Ketamine results in decreased expression of and results in decreased activity of CYP3A4 protein
Ketamine results in decreased expression of CYP3A4 mRNA
CTD PMID:18845661 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Cyp46a1 cytochrome P450, family 46, subfamily a, polypeptide 1 increases expression EXP Ketamine results in increased expression of CYP46A1 mRNA CTD PMID:20080153 NCBI chr 6:132,242,328...132,273,788
Ensembl chr 6:132,242,328...132,273,787
JBrowse link
G Daglb diacylglycerol lipase, beta decreases expression EXP Ketamine results in decreased expression of DAGLB mRNA CTD PMID:20080153 NCBI chr12:13,113,073...13,157,748
Ensembl chr12:13,113,237...13,157,666
JBrowse link
G Dbndd1 dysbindin domain containing 1 decreases expression EXP Ketamine results in decreased expression of DBNDD1 mRNA CTD PMID:20080153 NCBI chr19:56,302,704...56,311,991
Ensembl chr19:56,302,705...56,311,991
JBrowse link
G Dcaf13 DDB1 and CUL4 associated factor 13 decreases expression EXP Ketamine results in decreased expression of DCAF13 mRNA CTD PMID:20080153 NCBI chr 7:78,005,232...78,040,220
Ensembl chr 7:78,005,232...78,040,214
JBrowse link
G Dctd dCMP deaminase decreases expression EXP Ketamine results in decreased expression of DCTD mRNA CTD PMID:20080153 NCBI chr16:47,177,144...47,222,850
Ensembl chr16:47,177,145...47,208,110
JBrowse link
G Ddx31 DEAD-box helicase 31 decreases expression EXP Ketamine results in decreased expression of DDX31 mRNA CTD PMID:20080153 NCBI chr 3:7,422,871...7,488,299
Ensembl chr 3:7,422,820...7,488,617
JBrowse link
G Defb1 defensin beta 1 decreases expression EXP Ketamine results in decreased expression of DEFB1 mRNA CTD PMID:20080153 NCBI chr16:75,294,385...75,309,127
Ensembl chr16:75,294,376...75,309,176
JBrowse link
G Dennd2b DENN domain containing 2B increases expression EXP Ketamine results in increased expression of DENND2B mRNA CTD PMID:20080153 NCBI chr 1:174,137,120...174,290,533
Ensembl chr 1:174,137,120...174,289,647
JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 increases expression EXP Ketamine results in increased expression of DGAT2 mRNA CTD PMID:20080153 NCBI chr 1:164,113,459...164,143,818
Ensembl chr 1:164,113,459...164,143,818
JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) decreases expression EXP Ketamine results in decreased expression of DHODH mRNA CTD PMID:20080153 NCBI chr19:42,066,103...42,087,906
Ensembl chr19:42,066,351...42,082,012
JBrowse link
G Dhx36 DEAH-box helicase 36 decreases expression EXP Ketamine results in decreased expression of DHX36 mRNA CTD PMID:20080153 NCBI chr 2:152,785,844...152,824,549
Ensembl chr 2:152,785,844...152,824,547
JBrowse link
G Dipk1a divergent protein kinase domain 1A increases expression EXP Ketamine results in increased expression of DIPK1A mRNA CTD PMID:20080153 NCBI chr14:2,789,699...2,860,354
Ensembl chr14:2,789,650...2,860,333
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 decreases expression
multiple interactions
increases expression
ISO Ketamine results in decreased expression of DLG4 protein
Sirolimus inhibits the reaction [Ketamine results in increased expression of DLG4 protein]
CTD PMID:31470060 PMID:33022268 NCBI chr10:56,625,845...56,655,543
Ensembl chr10:56,627,411...56,653,599
JBrowse link
G Dlx5 distal-less homeobox 5 decreases expression EXP Ketamine results in decreased expression of DLX5 mRNA CTD PMID:20080153 NCBI chr 4:32,387,741...32,392,085
Ensembl chr 4:32,387,741...32,392,007
JBrowse link
G Dmac1 distal membrane arm assembly component 1 decreases expression EXP Ketamine results in decreased expression of DMAC1 mRNA CTD PMID:20080153 NCBI chr 5:92,038,050...92,039,146
Ensembl chr 5:92,038,050...92,039,146
JBrowse link
G Dmrtc1a DMRT-like family C1a increases expression EXP Ketamine results in increased expression of DMRTC1A mRNA CTD PMID:20080153 NCBI chr  X:72,624,660...72,654,258 JBrowse link
G Dmtf1 cyclin D binding myb-like transcription factor 1 decreases expression EXP Ketamine results in decreased expression of DMTF1 mRNA CTD PMID:20080153 NCBI chr 4:21,862,297...21,902,798
Ensembl chr 4:21,862,313...21,902,762
JBrowse link
G Dnajb14 DnaJ heat shock protein family (Hsp40) member B14 decreases expression EXP Ketamine results in decreased expression of DNAJB14 mRNA CTD PMID:20080153 NCBI chr 2:243,108,443...243,151,933
Ensembl chr 2:243,018,975...243,151,933
JBrowse link
G Dnajc15 DnaJ heat shock protein family (Hsp40) member C15 decreases expression EXP Ketamine results in decreased expression of DNAJC15 mRNA CTD PMID:20080153 NCBI chr15:59,990,131...60,056,710
Ensembl chr15:59,990,131...60,056,710
JBrowse link
G Dnm1 dynamin 1 increases expression EXP Ketamine results in increased expression of DNM1 mRNA CTD PMID:20080153 NCBI chr 3:11,338,081...11,382,043
Ensembl chr 3:11,338,083...11,382,043
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta decreases expression EXP Ketamine results in decreased expression of DNMT3B mRNA CTD PMID:20080153 NCBI chr 3:149,131,541...149,170,061
Ensembl chr 3:149,131,785...149,208,786
JBrowse link
G Dock11 dedicator of cytokinesis 11 decreases expression EXP Ketamine results in decreased expression of DOCK11 mRNA CTD PMID:20080153 NCBI chr  X:122,507,169...122,690,463
Ensembl chr  X:122,507,374...122,690,465
JBrowse link
G Dph5 diphthamide biosynthesis 5 decreases expression EXP Ketamine results in decreased expression of DPH5 mRNA CTD PMID:20080153 NCBI chr 2:218,834,034...218,866,763
Ensembl chr 2:218,834,034...218,866,761
JBrowse link
G Dpysl3 dihydropyrimidinase-like 3 decreases expression EXP Ketamine results in decreased expression of DPYSL3 mRNA CTD PMID:20080153 NCBI chr18:37,716,371...37,819,347
Ensembl chr18:37,716,143...37,819,097
JBrowse link
G Dtx4 deltex E3 ubiquitin ligase 4 decreases expression EXP Ketamine results in decreased expression of DTX4 mRNA CTD PMID:20080153 NCBI chr 1:228,729,842...228,759,783
Ensembl chr 1:228,732,985...228,755,866
JBrowse link
G Dusp11 dual specificity phosphatase 11 decreases expression EXP Ketamine results in decreased expression of DUSP11 mRNA CTD PMID:20080153 NCBI chr 4:117,617,640...117,631,674
Ensembl chr 4:117,617,533...117,631,716
Ensembl chr 4:117,617,533...117,631,716
JBrowse link
G Dusp22 dual specificity phosphatase 22 increases expression EXP Ketamine results in increased expression of DUSP22 mRNA CTD PMID:20080153 NCBI chr17:34,986,589...35,037,297
Ensembl chr17:34,986,591...35,037,076
JBrowse link
G Dync2i2 dynein 2 intermediate chain 2 decreases expression EXP Ketamine results in decreased expression of DYNC2I2 mRNA CTD PMID:20080153 NCBI chr 3:8,599,251...8,615,329
Ensembl chr 3:8,599,148...8,615,532
JBrowse link
G Ears2 glutamyl-tRNA synthetase 2, mitochondrial decreases expression EXP Ketamine results in decreased expression of EARS2 mRNA CTD PMID:20080153 NCBI chr 1:191,997,512...192,025,350
Ensembl chr 1:191,997,512...192,025,350
JBrowse link
G Ebp EBP, cholestenol delta-isomerase decreases expression EXP Ketamine results in decreased expression of EBP mRNA CTD PMID:20080153 NCBI chr  X:15,049,394...15,055,782
Ensembl chr  X:15,049,462...15,055,781
JBrowse link
G Ebpl EBP like decreases expression EXP Ketamine results in decreased expression of EBPL mRNA CTD PMID:20080153 NCBI chr15:41,668,119...41,691,518
Ensembl chr15:41,668,119...41,691,518
JBrowse link
G Echs1 enoyl-CoA hydratase, short chain 1 increases expression EXP Ketamine results in increased expression of ECHS1 protein CTD PMID:18504422 NCBI chr 1:212,570,213...212,579,040
Ensembl chr 1:212,570,195...212,579,057
Ensembl chr 1:212,570,195...212,579,057
JBrowse link
G Ect2 epithelial cell transforming 2 decreases expression EXP Ketamine results in decreased expression of ECT2 mRNA CTD PMID:20080153 NCBI chr 2:112,769,385...112,831,476
Ensembl chr 2:112,769,385...112,831,476
JBrowse link
G Edc3 enhancer of mRNA decapping 3 increases expression EXP Ketamine results in increased expression of EDC3 mRNA CTD PMID:20080153 NCBI chr 8:62,482,126...62,527,665
Ensembl chr 8:62,482,140...62,526,202
JBrowse link
G Eef2k eukaryotic elongation factor-2 kinase decreases expression EXP Ketamine results in decreased expression of EEF2K mRNA CTD PMID:20080153 NCBI chr 1:190,780,211...190,839,926
Ensembl chr 1:190,780,236...190,842,324
JBrowse link
G Efhb EF hand domain family, member B increases expression EXP Ketamine results in increased expression of EFHB mRNA CTD PMID:20080153 NCBI chr 9:47,988...120,800
Ensembl chr 9:47,724...120,799
JBrowse link
G Efna2 ephrin A2 decreases expression EXP Ketamine results in decreased expression of EFNA2 mRNA CTD PMID:20080153 NCBI chr 7:12,382,636...12,393,266
Ensembl chr 7:12,382,636...12,393,266
JBrowse link
G Egr4 early growth response 4 decreases expression EXP Ketamine results in decreased expression of EGR4 mRNA CTD PMID:20080153 NCBI chr 4:117,293,620...117,296,082
Ensembl chr 4:117,293,620...117,296,082
JBrowse link
G Eif1a eukaryotic translation initiation factor 1A decreases expression EXP Ketamine results in decreased expression of EIF1A mRNA CTD PMID:20080153 NCBI chr18:40,586,315...40,598,661
Ensembl chr18:40,586,315...40,597,671
JBrowse link
G Eif4e3 eukaryotic translation initiation factor 4E family member 3 decreases expression EXP Ketamine results in decreased expression of EIF4E3 mRNA CTD PMID:20080153 NCBI chr 4:132,068,581...132,111,092
Ensembl chr 4:132,068,598...132,111,079
JBrowse link
G Eno2 enolase 2 decreases expression EXP Ketamine results in decreased expression of ENO2 protein CTD PMID:18504422 NCBI chr 4:157,285,192...157,294,090
Ensembl chr 4:157,285,179...157,294,047
Ensembl chr 9:157,285,179...157,294,047
JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 increases expression EXP Ketamine results in increased expression of ENPP2 mRNA CTD PMID:20080153 NCBI chr 7:94,479,931...94,563,086
Ensembl chr 7:94,480,396...94,563,001
JBrowse link
G Ephx4 epoxide hydrolase 4 increases expression EXP Ketamine results in increased expression of EPHX4 mRNA CTD PMID:20080153 NCBI chr14:3,360,680...3,389,996
Ensembl chr14:3,360,712...3,389,943
JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 decreases expression ISO Ketamine results in decreased expression of ERBB4 mRNA CTD PMID:20000043 NCBI chr 9:75,021,790...76,178,936
Ensembl chr 9:75,021,790...75,528,644
JBrowse link
G Erich1 glutamate-rich 1 decreases expression EXP Ketamine results in decreased expression of ERICH1 mRNA CTD PMID:20080153 NCBI chr16:80,601,873...80,667,774
Ensembl chr16:80,601,973...80,667,781
JBrowse link
G Ermp1 endoplasmic reticulum metallopeptidase 1 increases expression EXP Ketamine results in increased expression of ERMP1 mRNA CTD PMID:20080153 NCBI chr 1:247,784,830...247,821,771
Ensembl chr 1:247,787,582...247,821,728
JBrowse link
G Ezh1 enhancer of zeste 1 polycomb repressive complex 2 subunit increases expression EXP Ketamine results in increased expression of EZH1 mRNA CTD PMID:20080153 NCBI chr10:89,104,026...89,139,978
Ensembl chr10:89,104,027...89,130,339
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit decreases expression EXP Ketamine results in decreased expression of EZH2 mRNA CTD PMID:20080153 NCBI chr 4:77,284,404...77,347,011
Ensembl chr 4:77,284,404...77,347,011
JBrowse link
G Fam110d family with sequence similarity 110, member D decreases expression EXP Ketamine results in decreased expression of FAM110D mRNA CTD PMID:20080153 NCBI chr 5:152,470,898...152,473,903
Ensembl chr 5:152,470,905...152,473,868
JBrowse link
G Fam120b family with sequence similarity 120B decreases expression EXP Ketamine results in decreased expression of FAM120B mRNA CTD PMID:20080153 NCBI chr 1:57,345,559...57,392,114
Ensembl chr 1:57,345,577...57,392,113
JBrowse link
G Fam136a family with sequence similarity 136, member A decreases expression EXP Ketamine results in decreased expression of FAM136A mRNA CTD PMID:20080153 NCBI chr 4:118,160,147...118,166,062
Ensembl chr 4:118,160,147...118,166,062
JBrowse link
G Fam180a family with sequence similarity 180, member A decreases expression EXP Ketamine results in decreased expression of FAM180A mRNA CTD PMID:20080153 NCBI chr 4:62,845,054...62,860,361
Ensembl chr 4:62,844,971...62,860,446
JBrowse link
G Fam189a2 family with sequence similarity 189, member A2 increases expression EXP Ketamine results in increased expression of FAM189A2 mRNA CTD PMID:20080153 NCBI chr 1:241,822,152...241,876,089
Ensembl chr 1:241,822,626...241,875,864
JBrowse link
G Fam210a family with sequence similarity 210, member A decreases expression EXP Ketamine results in decreased expression of FAM210A mRNA CTD PMID:20080153 NCBI chr18:64,045,023...64,084,594
Ensembl chr18:64,045,432...64,084,556
JBrowse link
G Fam71e1 family with sequence similarity 71, member E1 increases expression EXP Ketamine results in increased expression of FAM71E1 mRNA CTD PMID:20080153 NCBI chr 1:100,501,556...100,507,334
Ensembl chr 1:100,501,676...100,506,022
JBrowse link
G Fam98a family with sequence similarity 98, member A decreases expression EXP Ketamine results in decreased expression of FAM98A mRNA CTD PMID:20080153 NCBI chr 6:21,051,327...21,065,986
Ensembl chr 6:21,051,327...21,065,986
JBrowse link
G Fat3 FAT atypical cadherin 3 decreases expression EXP Ketamine results in decreased expression of FAT3 mRNA CTD PMID:20080153 NCBI chr 8:14,417,039...15,011,596
Ensembl chr 8:14,417,584...14,880,644
JBrowse link
G Fat4 FAT atypical cadherin 4 decreases expression EXP Ketamine results in decreased expression of FAT4 mRNA CTD PMID:20080153 NCBI chr 2:125,751,818...125,879,398
Ensembl chr 2:125,752,130...125,879,387
Ensembl chr 2:125,752,130...125,879,387
JBrowse link
G Faxc failed axon connections homolog, metaxin like GST domain containing increases expression EXP Ketamine results in increased expression of FAXC mRNA CTD PMID:20080153 NCBI chr 5:36,076,565...36,135,884
Ensembl chr 5:36,076,565...36,135,884
JBrowse link
G Fbl fibrillarin decreases expression EXP Ketamine results in decreased expression of FBL mRNA CTD PMID:20080153 NCBI chr 1:85,103,519...85,112,619
Ensembl chr 1:85,103,519...85,112,619
JBrowse link
G Fblim1 filamin binding LIM protein 1 decreases expression EXP Ketamine results in decreased expression of FBLIM1 mRNA CTD PMID:20080153 NCBI chr 5:160,122,466...160,158,921
Ensembl chr 5:160,122,425...160,158,386
JBrowse link
G Fbxl22 F-box and leucine-rich repeat protein 22 increases expression EXP Ketamine results in increased expression of FBXL22 mRNA CTD PMID:20080153 NCBI chr 8:72,198,043...72,204,730
Ensembl chr 8:72,198,043...72,204,730
JBrowse link
G Fbxo2 F-box protein 2 increases expression EXP Ketamine results in increased expression of FBXO2 mRNA CTD PMID:20080153 NCBI chr 5:164,972,483...164,977,912
Ensembl chr 5:164,972,480...164,977,916
JBrowse link
G Fbxo34 F-box protein 34 increases expression EXP Ketamine results in increased expression of FBXO34 mRNA CTD PMID:20080153 NCBI chr15:24,254,356...24,334,890
Ensembl chr15:24,254,042...24,334,890
JBrowse link
G Fbxo8 F-box protein 8 increases expression EXP Ketamine results in increased expression of FBXO8 mRNA CTD PMID:20080153 NCBI chr16:37,131,566...37,177,033
Ensembl chr16:37,131,345...37,177,033
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 decreases expression EXP Ketamine results in decreased expression of FDFT1 mRNA CTD PMID:20080153 NCBI chr15:46,339,248...46,367,302
Ensembl chr15:46,339,249...46,367,302
JBrowse link
G Fem1b fem-1 homolog B increases expression EXP Ketamine results in increased expression of FEM1B mRNA CTD PMID:20080153 NCBI chr 8:67,695,041...67,708,313
Ensembl chr 8:67,694,904...67,708,304
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 increases expression EXP Ketamine results in increased expression of FGFR3 mRNA CTD PMID:20080153 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706
JBrowse link
G Fgfrl1 fibroblast growth factor receptor-like 1 decreases expression EXP Ketamine results in decreased expression of FGFRL1 mRNA CTD PMID:20080153 NCBI chr14:2,020,110...2,032,169
Ensembl chr14:2,018,500...2,032,593
JBrowse link
G Fkbp15 FKBP prolyl isomerase family member 15 increases expression EXP Ketamine results in increased expression of FKBP15 mRNA CTD PMID:20080153 NCBI chr 5:78,133,357...78,229,311
Ensembl chr 5:78,133,886...78,183,122
JBrowse link
G Fn3k fructosamine 3 kinase increases expression EXP Ketamine results in increased expression of FN3K mRNA CTD PMID:20080153 NCBI chr10:110,626,462...110,642,262
Ensembl chr10:110,631,494...110,642,260
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Ketamine inhibits the reaction [Formaldehyde results in increased expression of FOS protein] CTD PMID:17551412 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Foxo1 forkhead box O1 decreases expression EXP Ketamine results in decreased expression of FOXO1 mRNA CTD PMID:20080153 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Frem3 FRAS1 related extracellular matrix 3 increases expression EXP Ketamine results in increased expression of FREM3 mRNA CTD PMID:20080153 NCBI chr19:30,973,329...31,032,331
Ensembl chr19:30,973,329...31,031,817
JBrowse link
G Fubp1 far upstream element binding protein 1 decreases expression EXP Ketamine results in decreased expression of FUBP1 mRNA CTD PMID:20080153 NCBI chr 2:257,425,676...257,452,745
Ensembl chr 2:257,425,679...257,449,568
JBrowse link
G Fxyd7 FXYD domain-containing ion transport regulator 7 increases expression EXP Ketamine results in increased expression of FXYD7 mRNA CTD PMID:20080153 NCBI chr 1:89,474,601...89,484,069
Ensembl chr 1:89,474,601...89,483,988
JBrowse link
G G0s2 G0/G1switch 2 decreases expression EXP Ketamine results in decreased expression of G0S2 mRNA CTD PMID:20080153 NCBI chr13:112,004,140...112,005,052
Ensembl chr13:112,004,140...112,005,052
JBrowse link
G Gabra5 gamma-aminobutyric acid type A receptor subunit alpha 5 increases expression ISO Ketamine results in increased expression of GABRA5 mRNA; Ketamine results in increased expression of GABRA5 protein CTD PMID:21712993 NCBI chr 1:112,833,941...112,947,482
Ensembl chr 1:112,833,944...112,947,451
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 decreases expression EXP Ketamine results in decreased expression of GABRB2 mRNA CTD PMID:20080153 NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565
JBrowse link
G Gabrd gamma-aminobutyric acid type A receptor subunit delta increases expression EXP Ketamine results in increased expression of GABRD mRNA CTD PMID:20080153 NCBI chr 5:172,797,478...172,809,374
Ensembl chr 5:172,797,450...172,809,353
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 decreases expression EXP Ketamine results in decreased expression of GABRG2 mRNA CTD PMID:20080153 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Gad1 glutamate decarboxylase 1 multiple interactions
increases expression
decreases expression
ISO acetovanillone inhibits the reaction [Ketamine results in decreased expression of GAD1 protein]
Ketamine results in increased expression of GAD1 mRNA
CTD PMID:18063801 PMID:23660488 NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157
JBrowse link
G Galnt16 polypeptide N-acetylgalactosaminyltransferase 16 increases expression EXP Ketamine results in increased expression of GALNT16 mRNA CTD PMID:20080153 NCBI chr 6:104,069,853...104,250,177
Ensembl chr 6:104,068,547...104,250,174
JBrowse link
G Galr2 galanin receptor 2 decreases expression EXP Ketamine results in decreased expression of GALR2 mRNA CTD PMID:20080153 NCBI chr10:105,156,793...105,159,221
Ensembl chr10:105,156,632...105,237,611
JBrowse link
G Gapdhs glyceraldehyde-3-phosphate dehydrogenase, spermatogenic increases expression EXP Ketamine results in increased expression of GAPDHS mRNA CTD PMID:20080153 NCBI chr 1:89,180,063...89,195,347
Ensembl chr 1:89,180,063...89,194,602
JBrowse link
G Gatad2b GATA zinc finger domain containing 2B decreases expression EXP Ketamine results in decreased expression of GATAD2B mRNA CTD PMID:20080153 NCBI chr 2:189,654,871...189,735,056
Ensembl chr 2:189,655,702...189,733,540
JBrowse link
G Gca grancalcin decreases expression EXP Ketamine results in decreased expression of GCA mRNA CTD PMID:20080153 NCBI chr 3:48,625,965...48,661,317
Ensembl chr 3:48,626,038...48,661,317
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression EXP Ketamine results in increased expression of GCLC mRNA CTD PMID:20080153 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gdap1l1 ganglioside-induced differentiation-associated protein 1-like 1 increases expression EXP Ketamine results in increased expression of GDAP1L1 mRNA CTD PMID:20080153 NCBI chr 3:159,823,791...159,843,260
Ensembl chr 3:159,823,878...159,842,278
JBrowse link
G Gfap glial fibrillary acidic protein increases expression EXP Ketamine results in increased expression of GFAP mRNA CTD PMID:20080153 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gfod2 glucose-fructose oxidoreductase domain containing 2 decreases expression EXP Ketamine results in decreased expression of GFOD2 mRNA CTD PMID:20080153 NCBI chr19:37,678,488...37,725,623
Ensembl chr19:37,682,734...37,725,623
JBrowse link
G Gfpt2 glutamine-fructose-6-phosphate transaminase 2 decreases expression EXP Ketamine results in decreased expression of GFPT2 mRNA CTD PMID:20080153 NCBI chr10:35,279,237...35,325,506
Ensembl chr10:35,279,236...35,325,508
JBrowse link
G Ggact gamma-glutamylamine cyclotransferase increases expression EXP Ketamine results in increased expression of GGACT mRNA CTD PMID:20080153 NCBI chr15:109,307,683...109,336,779
Ensembl chr15:109,307,904...109,316,953
JBrowse link
G Gjb6 gap junction protein, beta 6 increases expression EXP Ketamine results in increased expression of GJB6 mRNA CTD PMID:20080153 NCBI chr15:37,400,888...37,411,656
Ensembl chr15:37,400,889...37,410,848
JBrowse link
G Glul glutamate-ammonia ligase increases expression EXP Ketamine results in increased expression of GLUL protein CTD PMID:18504422 NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229
JBrowse link
G Gpr22 G protein-coupled receptor 22 increases expression EXP Ketamine results in increased expression of GPR22 mRNA CTD PMID:20080153 NCBI chr 6:51,012,421...51,021,253
Ensembl chr 6:51,011,426...51,019,407
JBrowse link
G Gpr37l1 G protein-coupled receptor 37-like 1 increases expression EXP Ketamine results in increased expression of GPR37L1 mRNA CTD PMID:20080153 NCBI chr13:51,985,698...51,992,547
Ensembl chr13:51,985,684...51,992,693
JBrowse link
G Gpr85 G protein-coupled receptor 85 decreases expression EXP Ketamine results in decreased expression of GPR85 mRNA CTD PMID:20080153 NCBI chr 4:40,377,705...40,387,147
Ensembl chr 4:40,381,685...40,385,349
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 decreases expression
multiple interactions
ISO Ketamine results in decreased expression