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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cyclic terpene ketone
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Accession:CHEBI:36130 term browser browse the term
Definition:An alicyclic ketone in which the carbocyclic ring structure forms part of a terpene skeleton.



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(+)-beta-thujone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions ISO beta-thujone inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; beta-thujone inhibits the reaction [Choline results in increased activity of CHRNA7 protein] CTD PMID:28395994 NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO beta-thujone inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:15588619 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions ISO beta-thujone inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:15588619 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO beta-thujone inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:15588619 NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346
JBrowse link
(R)-camphor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col1a2 collagen type I alpha 2 chain affects expression ISO Camphor analog affects the expression of COL1A2 mRNA CTD PMID:24704097 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity EXP Camphor results in decreased activity of CYP2B1 protein CTD PMID:9242356 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO Camphor inhibits the reaction [CYP2B6 protein results in increased hydrolysis of Bupropion] CTD PMID:18611395 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Camphor binds to and results in increased activity of ESR1 protein CTD PMID:27633901 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO Camphor promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:15588619 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions ISO Camphor promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:15588619 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO Camphor promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:15588619 NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Camphor inhibits the reaction [cinnamaldehyde results in increased activity of MPO protein] CTD PMID:21466812 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Camphor binds to and results in decreased activity of PGR protein CTD PMID:27633901 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Runx2 RUNX family transcription factor 2 affects expression ISO Camphor analog affects the expression of RUNX2 mRNA CTD PMID:24704097 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G Sparc secreted protein acidic and cysteine rich affects expression ISO Camphor analog affects the expression of SPARC mRNA CTD PMID:24704097 NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP Lidocaine promotes the reaction [Camphor results in increased activity of TRPV1 protein] CTD PMID:18172555 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 increases activity
multiple interactions
ISO Camphor results in increased activity of TRPV3 protein
isopentenyl pyrophosphate inhibits the reaction [Camphor results in increased activity of TRPV3 protein]
CTD PMID:21353389 NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296
JBrowse link
28-deoxonimbolide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO 28-deoxonimbolide results in increased activity of CASP3 protein CTD PMID:21381696 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity ISO 28-deoxonimbolide results in increased activity of CASP8 protein CTD PMID:21381696 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity ISO 28-deoxonimbolide results in increased activity of CASP9 protein CTD PMID:21381696 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
azadiradione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO azadiradione results in increased activity of CASP3 protein CTD PMID:21381696 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity ISO azadiradione results in increased activity of CASP8 protein CTD PMID:21381696 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity ISO azadiradione results in increased activity of CASP9 protein CTD PMID:21381696 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO azadiradione results in increased expression of HSPA1A mRNA CTD PMID:30309986 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
JBrowse link
beta-damascenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calml5 calmodulin-like 5 increases expression ISO beta-damascenone results in increased expression of CALM4 mRNA CTD PMID:22982537 NCBI chr17:66,394,433...66,395,352 JBrowse link
G Casp14 caspase 14 increases expression
affects localization
ISO beta-damascenone results in increased expression of CASP14 mRNA
beta-damascenone affects the localization of CASP14 protein
CTD PMID:22982537 NCBI chr 7:10,929,759...10,932,591
Ensembl chr 7:10,926,725...10,933,405
JBrowse link
G Ces3a carboxylesterase 3a increases expression ISO beta-damascenone results in increased expression of CES3 mRNA CTD PMID:22982537 NCBI chr19:32,992,386...33,000,562 JBrowse link
G Clca1 chloride channel accessory 1 increases expression ISO beta-damascenone results in increased expression of CLCA1 mRNA CTD PMID:22982537 NCBI chr 2:233,938,677...233,964,369
Ensembl chr 2:233,938,677...233,964,369
JBrowse link
G Clca2 chloride channel accessory 2 increases expression ISO beta-damascenone results in increased expression of CLCA2 mRNA CTD PMID:22982537 NCBI chr 2:233,993,619...234,022,691
Ensembl chr 2:233,995,078...234,022,199
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression ISO beta-damascenone results in increased expression of CYP17A1 mRNA CTD PMID:22982537 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Fcgbp Fc gamma binding protein increases expression ISO beta-damascenone results in increased expression of FCGBP mRNA CTD PMID:22982537 NCBI chr 1:83,374,979...83,413,082
Ensembl chr 1:83,372,127...83,413,083
JBrowse link
G Flg filaggrin increases expression ISO beta-damascenone results in increased expression of FLG mRNA; beta-damascenone results in increased expression of FLG protein CTD PMID:22982537 NCBI chr 2:178,884,793...178,912,986 JBrowse link
G Hrnr hornerin increases expression ISO beta-damascenone results in increased expression of HRNR mRNA CTD PMID:22982537
G Il20ra interleukin 20 receptor subunit alpha increases expression ISO beta-damascenone results in increased expression of IL20RA mRNA CTD PMID:22982537 NCBI chr 1:14,424,215...14,494,226
Ensembl chr 1:14,451,228...14,493,602
JBrowse link
G Il36rn interleukin 36 receptor antagonist increases expression ISO beta-damascenone results in increased expression of IL36RN mRNA CTD PMID:22982537 NCBI chr 3:7,044,419...7,051,016
Ensembl chr 3:7,044,406...7,051,016
JBrowse link
G Krt1 keratin 1 increases expression ISO beta-damascenone results in increased expression of KRT1 mRNA CTD PMID:22982537 NCBI chr 7:132,976,618...132,981,844
Ensembl chr 7:132,976,620...132,981,844
JBrowse link
G Krt10 keratin 10 increases expression ISO beta-damascenone results in increased expression of KRT10 mRNA CTD PMID:22982537 NCBI chr10:84,338,695...84,343,279
Ensembl chr10:84,338,706...84,343,701
JBrowse link
G Lce1b late cornified envelope 1B increases expression ISO beta-damascenone results in increased expression of LCE1B mRNA CTD PMID:22982537 NCBI chr 2:178,255,351...178,257,533
Ensembl chr 2:178,256,213...178,257,985
JBrowse link
G Lce1d late cornified envelope 1D increases expression ISO beta-damascenone results in increased expression of LCE1D mRNA CTD PMID:22982537
G Lce1f late cornified envelope 1F increases expression ISO beta-damascenone results in increased expression of LCE1F mRNA CTD PMID:22982537 NCBI chr 2:178,305,786...178,307,372
Ensembl chr 2:178,305,786...178,307,372
JBrowse link
G Lipm lipase, family member M increases expression ISO beta-damascenone results in increased expression of LIPM mRNA CTD PMID:22982537 NCBI chr 1:231,618,145...231,637,599
Ensembl chr 1:231,618,284...231,637,410
JBrowse link
G Loricrin loricrin cornified envelope precursor protein increases expression ISO beta-damascenone results in increased expression of LORICRIN mRNA CTD PMID:22982537 NCBI chr 2:177,558,062...177,560,960
Ensembl chr 2:177,558,252...177,559,807
JBrowse link
G Otop3 otopetrin 3 increases expression ISO beta-damascenone results in increased expression of OTOP3 mRNA CTD PMID:22982537 NCBI chr10:100,577,346...100,588,729
Ensembl chr10:100,577,392...100,588,726
JBrowse link
G Pla2g4f phospholipase A2, group IVF increases expression ISO beta-damascenone results in increased expression of PLA2G4F mRNA CTD PMID:22982537 NCBI chr 3:107,249,053...107,266,201
Ensembl chr 3:107,250,075...107,264,689
JBrowse link
G Plcxd1 phosphatidylinositol-specific phospholipase C, X domain containing 1 increases expression ISO beta-damascenone results in increased expression of PLCXD1 mRNA CTD PMID:22982537 NCBI chr12:46,578,917...46,582,181
Ensembl chr12:46,579,225...46,582,392
JBrowse link
G Sdr16c5 short chain dehydrogenase/reductase family 16C, member 5 increases expression ISO beta-damascenone results in increased expression of SDR16C5 mRNA CTD PMID:22982537 NCBI chr 5:17,018,813...17,043,974
Ensembl chr 5:17,018,813...17,040,970
JBrowse link
G Susd2 sushi domain containing 2 increases expression ISO beta-damascenone results in increased expression of SUSD2 mRNA CTD PMID:22982537 NCBI chr20:13,017,516...13,024,820
Ensembl chr20:13,017,477...13,024,903
JBrowse link
G Tmprss4 transmembrane serine protease 4 increases expression ISO beta-damascenone results in increased expression of TMPRSS4 mRNA CTD PMID:22982537 NCBI chr 8:45,475,819...45,508,409
Ensembl chr 8:45,476,053...45,508,409
JBrowse link
camphor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col1a2 collagen type I alpha 2 chain affects expression ISO Camphor analog affects the expression of COL1A2 mRNA CTD PMID:24704097 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity EXP Camphor results in decreased activity of CYP2B1 protein CTD PMID:9242356 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO Camphor inhibits the reaction [CYP2B6 protein results in increased hydrolysis of Bupropion] CTD PMID:18611395 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Camphor binds to and results in increased activity of ESR1 protein CTD PMID:27633901 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO Camphor promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:15588619 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions ISO Camphor promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:15588619 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO Camphor promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:15588619 NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Camphor inhibits the reaction [cinnamaldehyde results in increased activity of MPO protein] CTD PMID:21466812 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Camphor binds to and results in decreased activity of PGR protein CTD PMID:27633901 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Runx2 RUNX family transcription factor 2 affects expression ISO Camphor analog affects the expression of RUNX2 mRNA CTD PMID:24704097 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G Sparc secreted protein acidic and cysteine rich affects expression ISO Camphor analog affects the expression of SPARC mRNA CTD PMID:24704097 NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP Lidocaine promotes the reaction [Camphor results in increased activity of TRPV1 protein] CTD PMID:18172555 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 increases activity
multiple interactions
ISO Camphor results in increased activity of TRPV3 protein
isopentenyl pyrophosphate inhibits the reaction [Camphor results in increased activity of TRPV3 protein]
CTD PMID:21353389 NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296
JBrowse link
fenchone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO fenchone binds to and results in decreased activity of NR3C1 protein CTD PMID:27633901 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO fenchone binds to and results in decreased activity of PPARG protein CTD PMID:27633901 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
glycyrrhetinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 mRNA] CTD PMID:28549656 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; [Glycyrrhetinic Acid affects the activity of ABCB1 protein] which affects the susceptibility to Vinblastine; [Glycyrrhetinic Acid affects the activity of ABCB1 protein] which results in increased abundance of Daunorubicin; Glycyrrhetinic Acid inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; Glycyrrhetinic Acid inhibits the reaction [Verapamil results in increased activity of ABCB1 protein] CTD PMID:16904803 PMID:18204840 PMID:24380838 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB4 mRNA] CTD PMID:28549656 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
increases activity
ISO 18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCC1 mRNA]
Glycyrrhetinic Acid results in increased activity of ABCC1 protein
[Glycyrrhetinic Acid affects the activity of ABCC1 protein] which affects the susceptibility to Doxorubicin; [Glycyrrhetinic Acid affects the activity of ABCC1 protein] which results in increased abundance of fluorexon
CTD PMID:18204840 PMID:28549656 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions EXP Glycyrrhetinic Acid inhibits the reaction [ABCC2 protein results in increased transport of estradiol-17 beta-glucuronide] CTD PMID:18436619 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO 18alpha-glycyrrhetinic acid affects the reaction [1-Naphthylisothiocyanate affects the expression of ABCC3 mRNA] CTD PMID:28549656 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Glycyrrhetinic Acid inhibits the reaction [ABCG2 protein results in increased transport of estradiol-17 beta-glucuronide] CTD PMID:18436619 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCG5 mRNA] CTD PMID:28549656 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 multiple interactions ISO 18alpha-glycyrrhetinic acid affects the reaction [1-Naphthylisothiocyanate affects the expression of ACAT2 mRNA] CTD PMID:28549656 NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP 18alpha-glycyrrhetinic acid inhibits the reaction [Monocrotaline results in increased expression of ACTA2 protein] CTD PMID:31325423 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity ISO Glycyrrhetinic Acid results in decreased activity of AKR1C1 protein CTD PMID:12604236 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Glycyrrhetinic Acid results in decreased activity of AKR1C2 protein CTD PMID:12604236 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 affects activity
decreases activity
ISO 18alpha-glycyrrhetinic acid affects the activity of AKR1C3 protein
Glycyrrhetinic Acid results in decreased activity of AKR1C3 protein
CTD PMID:11165023 PMID:12604236 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Alb albumin multiple interactions ISO ALB protein binds to and affects the transport of Glycyrrhetinic Acid CTD PMID:8831264 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased activity of ALPL protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of ALPL mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [RUNX2 protein results in increased expression of ALPL mRNA] CTD PMID:21910061 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions EXP 18alpha-glycyrrhetinic acid inhibits the reaction [bisphenol A results in increased expression of ATF6 mRNA] CTD PMID:35699857 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Atp8b1 ATPase phospholipid transporting 8B1 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ATP8B1 mRNA] CTD PMID:28549656 NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [bisphenol A results in increased expression of BAX]; 18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in increased expression of BAX protein]
18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in decreased expression of BAX protein]
CTD PMID:28414158 PMID:31325423 PMID:35699857 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [bisphenol A results in decreased expression of BCL2]; 18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in decreased expression of BCL2 protein]
18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of BCL2 protein]
CTD PMID:28414158 PMID:31325423 PMID:35699857 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased activity of BGLAP protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of BGLAP mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [RUNX2 protein results in increased expression of BGLAP mRNA] CTD PMID:21910061 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased activity of ALPL protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased activity of BGLAP protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased activity of RUNX2 protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of ALPL mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of BGLAP mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of COL1A1 mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of SP7 mRNA] CTD PMID:21910061 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Casp3 caspase 3 multiple interactions EXP 18alpha-glycyrrhetinic acid inhibits the reaction [bisphenol A results in increased expression of CASP3] CTD PMID:35699857 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions ISO Glycyrrhetinic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of CAT mRNA] CTD PMID:23341968 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in decreased expression of CDKN1B protein] CTD PMID:31325423 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of COL1A1 mRNA] CTD PMID:21910061 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Glycyrrhetinic Acid promotes the reaction [Hydrocortisone inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]] CTD PMID:10460758 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP [brucine co-treated with Glycyrrhetinic Acid] results in decreased activity of CYP1A2 protein CTD PMID:21800547 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP [brucine co-treated with Glycyrrhetinic Acid] results in decreased activity of CYP2E1 protein CTD PMID:21800547 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 mRNA] CTD PMID:28549656 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP 18alpha-glycyrrhetinic acid inhibits the reaction [bisphenol A results in increased expression of EIF2AK3 mRNA] CTD PMID:35699857 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO
EXP
18alpha-glycyrrhetinic acid inhibits the reaction [Cadmium Chloride results in increased expression of ERN1 protein]
18alpha-glycyrrhetinic acid inhibits the reaction [bisphenol A results in increased expression of ERN1 mRNA]
CTD PMID:29444456 PMID:35699857 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions EXP 18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in increased activity of GGT1 protein] CTD PMID:28414158 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in increased activity of GPT protein]
18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased activity of GPT protein]; Glycyrrhetinic Acid inhibits the reaction [diosbulbin B results in increased activity of GPT protein]
CTD PMID:28414158 PMID:28549656 PMID:36807597 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions ISO Glycyrrhetinic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of GPX2 mRNA] CTD PMID:23341968 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP 18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in decreased expression of HMOX1 mRNA] CTD PMID:28414158 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hras HRas proto-oncogene, GTPase decreases expression ISO Glycyrrhetinic Acid results in decreased expression of HRAS protein CTD PMID:19958823 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases activity ISO 18alpha-glycyrrhetinic acid results in decreased activity of HSD11B1 protein CTD PMID:24135201 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity
multiple interactions
ISO 18alpha-glycyrrhetinic acid results in decreased activity of HSD11B2 protein
Glycyrrhetinic Acid inhibits the reaction [tributyltin results in increased activity of HSD11B2 protein]; Glycyrrhetinic Acid inhibits the reaction [triphenyltin chloride results in increased activity of HSD11B2 protein]
CTD PMID:24135201 PMID:31927052 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions ISO [Glycyrrhetinic Acid co-treated with NADP] binds to HSD3B1 protein CTD PMID:25526675 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP 18alpha-glycyrrhetinic acid inhibits the reaction [bisphenol A results in increased expression of HSPA5 mRNA] CTD PMID:35699857 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
Glycyrrhetinic Acid promotes the reaction [Hydrocortisone inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]]
Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B mRNA]
18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in increased expression of IL1B protein]
CTD PMID:10460758 PMID:23373965 PMID:28414158 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA] CTD PMID:21644799 PMID:23373965 PMID:24849676 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO Glycyrrhetinic Acid inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] promotes the reaction [TRAF6 protein binds to IRAK1 protein]] CTD PMID:28213090 NCBI chr  X:151,768,621...151,778,521
Ensembl chr  X:151,768,777...151,778,521
JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 multiple interactions
increases expression
ISO [Glycyrrhetinic Acid co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IRAK3 mRNA; IRAK3 protein promotes the reaction [Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]]
Glycyrrhetinic Acid results in increased expression of IRAK3 protein
CTD PMID:28213090 NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121
JBrowse link
G Ly96 lymphocyte antigen 96 multiple interactions ISO Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of [TLR4 protein binds to LY96 protein]] CTD PMID:28213090 NCBI chr 5:2,582,233...2,612,357
Ensembl chr 5:2,582,254...2,612,386
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [Cadmium Chloride results in increased expression of MAP3K5 protein] CTD PMID:29444456 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK1 protein] CTD PMID:23373965 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK3 protein] CTD PMID:23373965 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased activity of MMP9 protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA] CTD PMID:24613819 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Glycyrrhetinic Acid inhibits the reaction [diosbulbin B results in increased activity of MPO protein] CTD PMID:36807597 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of MTTP mRNA] CTD PMID:28549656 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression
ISO
EXP
[Glycyrrhetinic Acid results in increased expression of NFE2L2] which results in decreased susceptibility to Carbon Tetrachloride; Glycyrrhetinic Acid inhibits the reaction [Carbon Tetrachloride affects the localization of NFE2L2 protein]
18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in decreased expression of NFE2L2 mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in decreased expression of NFE2L2 protein]
CTD PMID:23341968 PMID:28414158 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in decreased expression of NFKB1 protein] CTD PMID:24613819 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
Glycyrrhetinic Acid inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in increased phosphorylation of NFKBIA protein]; Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of and affects the localization of NFKBIA protein]
CTD PMID:23373965 PMID:24613819 PMID:28213090 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein] CTD PMID:21644799 PMID:23373965 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of NPC1L1 mRNA] CTD PMID:28549656 NCBI chr14:81,071,448...81,091,113
Ensembl chr14:81,071,451...81,091,113
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions EXP glycyrrhetinic acid inhibits the reaction [1-naphthyl isothiocyanate decreases expression of Nr1h4 mRNA in liver] RGD PMID:30061734 RGD:15092071 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in decreased expression of BAX protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in decreased expression of CDKN1B protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of BCL2 protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of RHOA mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of RHOA protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of ROCK1 mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of ROCK1 protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of ROCK2 mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of ROCK2 protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased phosphorylation of PPP1R12A protein] CTD PMID:31325423 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta decreases activity ISO 18alpha-glycyrrhetinic acid results in decreased activity of PIK3CD protein CTD PMID:21644799 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma decreases activity ISO 18alpha-glycyrrhetinic acid results in decreased activity of PIK3CG protein CTD PMID:21644799 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP 18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in decreased expression of PPARG mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in decreased expression of PPARG protein] CTD PMID:28414158 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased phosphorylation of PPP1R12A protein] CTD PMID:31325423 NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein] CTD PMID:21644799 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in decreased expression of RELA protein]
Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of RELA protein]
CTD PMID:23373965 PMID:24613819 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Ren renin decreases activity ISO Glycyrrhetinic Acid results in decreased activity of REN protein CTD PMID:20460744 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of RHOA mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of RHOA protein] CTD PMID:31325423 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of ROCK1 mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of ROCK1 protein] CTD PMID:31325423 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of ROCK2 mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of ROCK2 protein] CTD PMID:31325423 NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased activity of RUNX2 protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [RUNX2 protein results in increased expression of ALPL mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [RUNX2 protein results in increased expression of BGLAP mRNA] CTD PMID:21910061 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G Slc51b SLC51 subunit beta multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of SLC51B mRNA] CTD PMID:28549656 NCBI chr 8:65,931,891...65,939,953
Ensembl chr 8:65,931,890...65,940,145
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of SLCO1A4 mRNA] CTD PMID:28549656 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions ISO Glycyrrhetinic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of SOD3 mRNA] CTD PMID:23341968 NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990
JBrowse link
G Sp7 Sp7 transcription factor multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of SP7 mRNA] CTD PMID:21910061 NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of [TLR4 protein binds to LY96 protein]] CTD PMID:28213090 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
18alpha-glycyrrhetinic acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; Glycyrrhetinic Acid inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in increased expression of and results in increased secretion of TNF protein]; Glycyrrhetinic Acid inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in increased expression of TNF mRNA]; Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; IRAK3 protein promotes the reaction [Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]]
18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in increased expression of TNF protein]
18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in decreased expression of NFKB1 protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in decreased expression of RELA protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased activity of MMP9 protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of VEGFA protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
CTD PMID:21644799 PMID:24613819 PMID:28213090 PMID:28414158 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO Glycyrrhetinic Acid inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] promotes the reaction [TRAF6 protein binds to IRAK1 protein]] CTD PMID:28213090 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of VEGFA protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA] CTD PMID:24613819 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [Cadmium Chloride results in increased expression of XBP1 protein alternative form] CTD PMID:29444456 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link
hyperforin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
multiple interactions
ISO hyperforin results in increased expression of ABCB1; hyperforin results in increased expression of ABCB1 mRNA
hyperforin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]
CTD PMID:15266218 PMID:16005588 PMID:24259679 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 increases expression ISO hyperforin results in increased expression of ALAS1 mRNA CTD PMID:24259679 NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO hyperforin results in increased expression of BAK1 protein CTD PMID:32485087 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
multiple interactions
increases expression
EXP
ISO
hyperforin results in decreased expression of BAX mRNA
hyperforin inhibits the reaction [aluminum maltolate results in increased expression of BAX mRNA]
hyperforin results in increased expression of BAX protein
CTD PMID:30481499 PMID:32485087 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
ISO
EXP
hyperforin inhibits the reaction [aluminum maltolate results in decreased expression of BCL2 mRNA]
hyperforin results in increased expression of BCL2 mRNA
CTD PMID:30481499 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
decreases expression
ISO
EXP
hyperforin inhibits the reaction [aluminum maltolate results in increased activity of CASP3 protein]; hyperforin inhibits the reaction [aluminum maltolate results in increased expression of CASP3 mRNA]
hyperforin results in increased cleavage of CASP3 protein
hyperforin results in decreased expression of CASP3 mRNA
hyperforin inhibits the reaction [aluminum maltolate results in increased activity of CASP3 protein]; hyperforin inhibits the reaction [aluminum maltolate results in increased expression of CASP3 mRNA]; hyperforin inhibits the reaction [Propofol results in increased cleavage of CASP3 protein]
CTD PMID:30481499 PMID:32485087 PMID:36640868 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases cleavage ISO hyperforin results in increased cleavage of CASP8 protein CTD PMID:32485087 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO hyperforin results in decreased expression of CCND1 protein CTD PMID:32485087 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression ISO hyperforin results in decreased expression of CFLAR protein CTD PMID:32485087 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
JBrowse link
G Cycs cytochrome c, somatic multiple interactions
decreases expression
EXP
ISO
hyperforin inhibits the reaction [aluminum maltolate results in increased expression of CYCS protein]
hyperforin results in decreased expression of CYCS protein
CTD PMID:30481499 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
ISO hyperforin inhibits the reaction [CYP1A1 protein affects the metabolism of benzo(a)pyrene 7,8-dihydrodiol]
hyperforin results in decreased activity of CYP1A1 protein
CTD PMID:14633740 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 increases expression ISO hyperforin results in increased expression of CYP24A1 mRNA CTD PMID:15630458 NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO hyperforin results in increased expression of CYP2B6 mRNA CTD PMID:24259679 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases expression
multiple interactions
ISO hyperforin results in increased expression of CYP2C9 mRNA
hyperforin results in increased expression of and results in increased activity of CYP2C9 protein; NR1I2 protein affects the reaction [hyperforin results in increased expression of CYP2C9 mRNA]
CTD PMID:14600250 PMID:15100173 PMID:24259679 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions
decreases activity
ISO hyperforin results in increased expression of CYP3A4; hyperforin results in increased expression of CYP3A4 mRNA
hyperforin results in increased expression of and results in increased activity of CYP3A4 protein
hyperforin results in decreased activity of CYP3A4 protein
CTD PMID:15100173 PMID:15266218 PMID:16005588 PMID:16442130 PMID:17954527 More... NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases expression ISO hyperforin results in increased expression of CYP3A5 mRNA CTD PMID:24259679 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO hyperforin results in decreased expression of CYP7A1 mRNA CTD PMID:24259679 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Egfr epidermal growth factor receptor decreases phosphorylation ISO hyperforin results in decreased phosphorylation of EGFR protein CTD PMID:32485087 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO hyperforin results in increased expression of FAS protein CTD PMID:32485087 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand increases expression ISO hyperforin results in increased expression of FASLG protein CTD PMID:32485087 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO hyperforin results in increased expression of ICAM1 mRNA CTD PMID:15622447 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO hyperforin promotes the reaction [JUN protein binds to CXCL8 promoter] CTD PMID:15622447 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
decreases phosphorylation
ISO hyperforin results in increased phosphorylation of MAPK1 protein
hyperforin results in decreased phosphorylation of MAPK1 protein
CTD PMID:15622447 PMID:32485087 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
decreases phosphorylation
ISO hyperforin results in increased phosphorylation of MAPK3 protein
hyperforin results in decreased phosphorylation of MAPK3 protein
CTD PMID:15622447 PMID:32485087 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO hyperforin results in decreased expression of MCL1 protein CTD PMID:32485087 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases response to substance
affects binding
increases activity
ISO [NR1I2 protein co-treated with hyperforin] results in decreased expression of SLC22A1 mRNA; [NR1I2 protein results in increased susceptibility to hyperforin] which results in decreased expression of SLC22A1 mRNA; hyperforin binds to and results in increased activity of NR1I2 protein; hyperforin promotes the reaction [NR1I2 protein results in decreased expression of SLC22A1 mRNA]; NR1I2 protein affects the reaction [hyperforin results in increased expression of CYP2C9 mRNA]; NR1I2 protein promotes the reaction [hyperforin results in increased abundance of Lipids]
hyperforin binds to NR1I2 protein
hyperforin results in increased activity of NR1I2 protein
CTD PMID:14600250 PMID:15630458 PMID:15856409 PMID:20079722 PMID:26187274 More... NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Por cytochrome p450 oxidoreductase increases expression ISO hyperforin results in increased expression of POR mRNA CTD PMID:24259679 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases expression
multiple interactions
ISO hyperforin results in decreased expression of SLC22A1 protein
[NR1I2 protein co-treated with hyperforin] results in decreased expression of SLC22A1 mRNA; [NR1I2 protein results in increased susceptibility to hyperforin] which results in decreased expression of SLC22A1 mRNA; hyperforin promotes the reaction [NR1I2 protein results in decreased expression of SLC22A1 mRNA]
CTD PMID:26920453 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 multiple interactions EXP hyperforin inhibits the reaction [Propofol results in decreased expression of TRPC6 protein] CTD PMID:36640868 NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO hyperforin results in increased expression of UGT1A1 mRNA CTD PMID:24259679 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO hyperforin results in decreased expression of XIAP protein CTD PMID:32485087 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
lucidenic acid N term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmox1 heme oxygenase 1 increases expression ISO lucidenic acid N analog results in increased expression of HMOX1 protein CTD PMID:25239868 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
omaveloxolone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO omaveloxolone analog inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of ADIPOQ protein] CTD PMID:32410268 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions ISO omaveloxolone analog promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of FTH1 mRNA]; omaveloxolone promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of FTH1 mRNA] CTD PMID:32410268 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [omaveloxolone analog co-treated with Streptozocin co-treated with Dietary Fats] results in increased expression of GPT protein CTD PMID:32410268 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Lep leptin multiple interactions ISO omaveloxolone analog promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of LEP protein] CTD PMID:32410268 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [omaveloxolone analog co-treated with Streptozocin co-treated with Dietary Fats] results in increased activity of NQO1 protein; [omaveloxolone co-treated with Streptozocin co-treated with Dietary Fats] results in increased activity of NQO1 protein; omaveloxolone analog promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NQO1 mRNA]; omaveloxolone promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NQO1 mRNA] CTD PMID:32410268 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Srxn1 sulfiredoxin 1 multiple interactions ISO omaveloxolone analog promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of SRXN1 mRNA]; omaveloxolone promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of SRXN1 mRNA] CTD PMID:32410268 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
JBrowse link
rubiarbonone C term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects activity ISO rubiarbonone C affects the activity of CYP3A4 protein CTD PMID:30259074 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 decreases activity
multiple interactions
ISO rubiarbonone C results in decreased activity of CYP4F3 protein alternative form
rubiarbonone C inhibits the reaction [CYP4F3 protein alternative form results in increased hydroxylation of Arachidonic Acid]
CTD PMID:30259074 NCBI chr16:17,763,543...17,804,944
Ensembl chr16:17,707,317...17,804,940
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    chemical entity 19916
      group 19875
        inorganic group 19454
          oxo group 18922
            organic oxo compound 18922
              carbonyl compound 18922
                ketone 17210
                  terpene ketone 158
                    cyclic terpene ketone 146
                      (+)-(5S)-12-hydroxy-2-oxo-20-norabieta-1(10),8,11,13-tetraene 0
                      (+)-(5S,10R)-10,12-dihydroxy-7-oxo-20-norabieta-8,11,13-triene 0
                      (+)-(5S,6S,10R)-12-hydroxy-7-oxo-abieta-8,11,13-trien-20-oic acid6,20-lactone 0
                      (+)-(5S,6S,7S,8R,10R)-6-hydroxy-7,8-epoxy-12-oxo-abieta-9(11),13-dien-20-oic acid 6,20-lactone 0
                      (+)-(5S,7R)-7-ethoxy-12-hydroxy-2-oxo-20-norabieta-1(10),8,11,13-tetraene 0
                      (-)-(4S,5S,10R)-10,12,18-trihydroxy-7-oxo-20-norabieta-8,11,13-triene 0
                      (-)-(4S,5S,10R,20R)-12,18-dihydroxy-7-oxo-abieta-8,11,13-trien-20-aldehyde 18,20-ethyl acetal 0
                      (-)-(4S,5S,8R,10R)-8,18-dihydroxy-12-oxo-abieta-9(11),13-dien-20-oic acid 18,20-lactone 0
                      (-)-(4S,5S,8R,10R,20S)-8,18-dihydroxy-12-oxo-abieta-9(11),13-dien-20-aldehyde 8,18,20-acetal 0
                      (-)-(5R,10S)-12-hydroxy-7-oxo-20-norabieta-8,11,13-triene 0
                      (-)-leucophyllone 0
                      (3R)-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylic acid 0
                      1-oxo-3beta,23-dihydroxyolean-12-en-28-oic acid 0
                      1-oxo-3beta,23-dihydroxyolean-12-en-28-oic acid 28-O-beta-D-glucopyranoside 0
                      1-oxo-3beta-hydroxyolean-18-ene 0
                      11,13-dihydro-8-deoxylactucin 15-glycoside 0
                      11,20-dihydroxysugiol 0
                      11-hydroxysugiol + 0
                      11-oxo-beta-amyrin 0
                      11-oxocucurbitadienol 0
                      11beta,13-dihydro-8-deoxylactucin 0
                      11beta,13-dihydro-8-deoxylactucin 15-oxalate 0
                      11beta,13-dihydrolactucin 0
                      11beta,13-dihydrolactucin 15-glycoside 0
                      11beta,13-dihydrolactucin 15-oxalate 0
                      11beta,13-dihydrolactucopicrin 0
                      11beta,13-dihydrolactucopicrin 15-oxalate 0
                      12-hydroxy-1-oxo-20-norabieta-5(10),6,8,11,13-pentaene 0
                      13-methyl-4,4-bisnorpodocarpa-8,11,13-trien-3-one 0
                      15-hydroxyazadiradione 0
                      16,23,29-trihydroxy-3-oxo-olean-12-en-28-oic acid 0
                      17-defurano-17-oxosalannin 0
                      17-epi-17-hydroxyazadiradione 0
                      17-epiazadiradione + 0
                      17-hydroxyazadiradione 0
                      17beta,21beta-epoxyhopan-3-one 0
                      1beta-hydroxyfriedelin 0
                      2-hydroxyrubiarbonone E 0
                      20,21,22,23-tetrahydro-23-oxoazadirone 0
                      20S,24S-dihydroxydammer-25-en-3-one 0
                      24,25-dihydroxydammar-20-en-3-one 0
                      24,25-epoxytirucall-7-ene-3,23-dione 0
                      28,29-dihydroxyfriedelan-3-one 0
                      28-deoxonimbolide 3
                      29-hydroxyfriedelan-3-one 0
                      3-oxo-23-hydroxyurs-12-en-28-oic acid 0
                      30-hydroxy-11-oxo-beta-amyrin 0
                      6-acetylnimbandiol 0
                      6-deacetylnimbin 0
                      7-acetyl-16,17-dehydro-16-hydroxyneotrichilenone 0
                      7-benzoylnimbocinol 0
                      7-deacetyl-17-epinimolicinol 0
                      7-deacetyl-7-benzoylepoxyazadiradione 0
                      7-deacetyl-7-benzoylgedunin 0
                      7-deacetylgedunin 0
                      7-oxo-10alpha-cucurbitadienol 0
                      8-deoxylactucin 15-oxalate 0
                      8-deoxylactucin-15-glycoside 0
                      8-hydroxy-12-oxoabieta-9(11),13-dien-20-oic 8,20-lactone 0
                      CJ-01 0
                      aglaiabbreviatin A 0
                      aglaiabbreviatin D 0
                      aglaiabbreviatin E 0
                      albaflavenone 0
                      alpha-nimolactone 0
                      azadiradione + 4
                      azadiradionolide 0
                      azadirone + 0
                      berkeleydione 0
                      berkeleyone A 0
                      berkeleyone B 0
                      berkeleyone C 0
                      berkeleytrione 0
                      beta-nimolactone 0
                      cabralealactone 0
                      cabraleone 0
                      camphenilone 0
                      cangoronin 0
                      canophyllal 0
                      caribenol B 0
                      celasdin B 0
                      clethroidoside C 0
                      clethroidoside D 0
                      clethroidoside G 0
                      cneorin-NP36 0
                      combretanone A 0
                      combretanone B 0
                      combretanone C 0
                      combretanone D 0
                      combretanone E 0
                      combretanone F 0
                      combretanone G 0
                      cornusalterin B 0
                      cornusalterin D 0
                      cornusalterin E 0
                      cornusalterin F 0
                      cornusalterin G 0
                      cornusalterin H 0
                      cornusalterin I 0
                      cornusalterin K 0
                      cornusalterin L 0
                      cyclic monoterpene ketone + 37
                      cycloeucalenone 0
                      dehydroeburiconic acid 0
                      deoxyflindissone 0
                      desfuranoazadiradione 0
                      dysolenticin B 0
                      dysolenticin C 0
                      dysolenticin D 0
                      dysolenticin G 0
                      dysolenticin H 0
                      dysolenticin I 0
                      ent-3beta-hydroxycassa-12,15-dien-2-one 0
                      ent-cassa-12,15-dien-2-one 0
                      epoxyazadiradione + 0
                      fenchone + 2
                      friedelin + 0
                      glochidone 0
                      glochidonol 0
                      glycyrrhetaldehyde 0
                      glycyrrhetinic acid + 78
                      hyperforin 31
                      ingenol + 0
                      ingenol mebutate 0
                      jasmonate ester + 0
                      kansuiphorin A 0
                      kansuiphorin B 0
                      lactucin + 0
                      lactucin 15-glycoside 0
                      lactucin 15-oxalate 0
                      lactucopicrin 0
                      lactucopicrin 15-oxalate 0
                      lamesticumin C 0
                      lamesticumin D 0
                      lamesticumin E 0
                      lamesticumin F 0
                      lanosta-9(11),24-dien-3-one 0
                      laxiracemosin H 0
                      lucialdehyde B 0
                      lucialdehyde C 0
                      lucidenic acid N 1
                      marianine 0
                      maytenfolone A 0
                      megathyrin A 0
                      michaolide D 0
                      nimbin + 0
                      nimbocinol + 0
                      nimolicinol 0
                      ocotillone 0
                      omaveloxolone 6
                      paraherquonin 0
                      piperitone + 0
                      preaustinoid A 0
                      preaustinoid A1 0
                      preaustinoid A2 0
                      protoaustinoid A 0
                      protoaustinoid B 0
                      rubiarbonone A 0
                      rubiarbonone B 0
                      rubiarbonone C 2
                      rubiarbonone E 19-acetate 0
                      rubiyunnanol C 0
                      shionone 0
                      sugiol + 0
                      terretonin 0
                      thujone + 4
                      triptobenzene A 0
                      triptohypol A 0
                      triptohypol B 0
                      triptonolide 0
                      triptonoterpene 0
                      triptoquinone A 0
                      triptoquinone B 0
                      triptoquinone H 0
                      vibsanin B 0
                      virgatic acid 0
                      wilforic acid C 0
                      wilforol A 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic group 18995
                              organic divalent group 18969
                                organodiyl group 18969
                                  carbonyl group 18922
                                    carbonyl compound 18922
                                      ketone 17210
                                        cyclic ketone 15715
                                          alicyclic ketone 1151
                                            cyclic terpene ketone 146
                                              (+)-(5S)-12-hydroxy-2-oxo-20-norabieta-1(10),8,11,13-tetraene 0
                                              (+)-(5S,10R)-10,12-dihydroxy-7-oxo-20-norabieta-8,11,13-triene 0
                                              (+)-(5S,6S,10R)-12-hydroxy-7-oxo-abieta-8,11,13-trien-20-oic acid6,20-lactone 0
                                              (+)-(5S,6S,7S,8R,10R)-6-hydroxy-7,8-epoxy-12-oxo-abieta-9(11),13-dien-20-oic acid 6,20-lactone 0
                                              (+)-(5S,7R)-7-ethoxy-12-hydroxy-2-oxo-20-norabieta-1(10),8,11,13-tetraene 0
                                              (-)-(4S,5S,10R)-10,12,18-trihydroxy-7-oxo-20-norabieta-8,11,13-triene 0
                                              (-)-(4S,5S,10R,20R)-12,18-dihydroxy-7-oxo-abieta-8,11,13-trien-20-aldehyde 18,20-ethyl acetal 0
                                              (-)-(4S,5S,8R,10R)-8,18-dihydroxy-12-oxo-abieta-9(11),13-dien-20-oic acid 18,20-lactone 0
                                              (-)-(4S,5S,8R,10R,20S)-8,18-dihydroxy-12-oxo-abieta-9(11),13-dien-20-aldehyde 8,18,20-acetal 0
                                              (-)-(5R,10S)-12-hydroxy-7-oxo-20-norabieta-8,11,13-triene 0
                                              (-)-leucophyllone 0
                                              (3R)-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylic acid 0
                                              1-oxo-3beta,23-dihydroxyolean-12-en-28-oic acid 0
                                              1-oxo-3beta,23-dihydroxyolean-12-en-28-oic acid 28-O-beta-D-glucopyranoside 0
                                              1-oxo-3beta-hydroxyolean-18-ene 0
                                              11,13-dihydro-8-deoxylactucin 15-glycoside 0
                                              11,20-dihydroxysugiol 0
                                              11-hydroxysugiol + 0
                                              11-oxo-beta-amyrin 0
                                              11-oxocucurbitadienol 0
                                              11beta,13-dihydro-8-deoxylactucin 0
                                              11beta,13-dihydro-8-deoxylactucin 15-oxalate 0
                                              11beta,13-dihydrolactucin 0
                                              11beta,13-dihydrolactucin 15-glycoside 0
                                              11beta,13-dihydrolactucin 15-oxalate 0
                                              11beta,13-dihydrolactucopicrin 0
                                              11beta,13-dihydrolactucopicrin 15-oxalate 0
                                              12-hydroxy-1-oxo-20-norabieta-5(10),6,8,11,13-pentaene 0
                                              13-methyl-4,4-bisnorpodocarpa-8,11,13-trien-3-one 0
                                              15-hydroxyazadiradione 0
                                              16,23,29-trihydroxy-3-oxo-olean-12-en-28-oic acid 0
                                              17-defurano-17-oxosalannin 0
                                              17-epi-17-hydroxyazadiradione 0
                                              17-epiazadiradione + 0
                                              17-hydroxyazadiradione 0
                                              17beta,21beta-epoxyhopan-3-one 0
                                              1beta-hydroxyfriedelin 0
                                              2-hydroxyrubiarbonone E 0
                                              20,21,22,23-tetrahydro-23-oxoazadirone 0
                                              20S,24S-dihydroxydammer-25-en-3-one 0
                                              24,25-dihydroxydammar-20-en-3-one 0
                                              24,25-epoxytirucall-7-ene-3,23-dione 0
                                              28,29-dihydroxyfriedelan-3-one 0
                                              28-deoxonimbolide 3
                                              29-hydroxyfriedelan-3-one 0
                                              3-oxo-23-hydroxyurs-12-en-28-oic acid 0
                                              30-hydroxy-11-oxo-beta-amyrin 0
                                              6-acetylnimbandiol 0
                                              6-deacetylnimbin 0
                                              7-acetyl-16,17-dehydro-16-hydroxyneotrichilenone 0
                                              7-benzoylnimbocinol 0
                                              7-deacetyl-17-epinimolicinol 0
                                              7-deacetyl-7-benzoylepoxyazadiradione 0
                                              7-deacetyl-7-benzoylgedunin 0
                                              7-deacetylgedunin 0
                                              7-oxo-10alpha-cucurbitadienol 0
                                              8-deoxylactucin 15-oxalate 0
                                              8-deoxylactucin-15-glycoside 0
                                              8-hydroxy-12-oxoabieta-9(11),13-dien-20-oic 8,20-lactone 0
                                              CJ-01 0
                                              aglaiabbreviatin A 0
                                              aglaiabbreviatin D 0
                                              aglaiabbreviatin E 0
                                              albaflavenone 0
                                              alpha-nimolactone 0
                                              azadiradione + 4
                                              azadiradionolide 0
                                              azadirone + 0
                                              berkeleydione 0
                                              berkeleyone A 0
                                              berkeleyone B 0
                                              berkeleyone C 0
                                              berkeleytrione 0
                                              beta-nimolactone 0
                                              cabralealactone 0
                                              cabraleone 0
                                              camphenilone 0
                                              cangoronin 0
                                              canophyllal 0
                                              caribenol B 0
                                              celasdin B 0
                                              clethroidoside C 0
                                              clethroidoside D 0
                                              clethroidoside G 0
                                              cneorin-NP36 0
                                              combretanone A 0
                                              combretanone B 0
                                              combretanone C 0
                                              combretanone D 0
                                              combretanone E 0
                                              combretanone F 0
                                              combretanone G 0
                                              cornusalterin B 0
                                              cornusalterin D 0
                                              cornusalterin E 0
                                              cornusalterin F 0
                                              cornusalterin G 0
                                              cornusalterin H 0
                                              cornusalterin I 0
                                              cornusalterin K 0
                                              cornusalterin L 0
                                              cyclic monoterpene ketone + 37
                                              cycloeucalenone 0
                                              dehydroeburiconic acid 0
                                              deoxyflindissone 0
                                              desfuranoazadiradione 0
                                              dysolenticin B 0
                                              dysolenticin C 0
                                              dysolenticin D 0
                                              dysolenticin G 0
                                              dysolenticin H 0
                                              dysolenticin I 0
                                              ent-3beta-hydroxycassa-12,15-dien-2-one 0
                                              ent-cassa-12,15-dien-2-one 0
                                              epoxyazadiradione + 0
                                              fenchone + 2
                                              friedelin + 0
                                              glochidone 0
                                              glochidonol 0
                                              glycyrrhetaldehyde 0
                                              glycyrrhetinic acid + 78
                                              hyperforin 31
                                              ingenol + 0
                                              ingenol mebutate 0
                                              jasmonate ester + 0
                                              kansuiphorin A 0
                                              kansuiphorin B 0
                                              lactucin + 0
                                              lactucin 15-glycoside 0
                                              lactucin 15-oxalate 0
                                              lactucopicrin 0
                                              lactucopicrin 15-oxalate 0
                                              lamesticumin C 0
                                              lamesticumin D 0
                                              lamesticumin E 0
                                              lamesticumin F 0
                                              lanosta-9(11),24-dien-3-one 0
                                              laxiracemosin H 0
                                              lucialdehyde B 0
                                              lucialdehyde C 0
                                              lucidenic acid N 1
                                              marianine 0
                                              maytenfolone A 0
                                              megathyrin A 0
                                              michaolide D 0
                                              nimbin + 0
                                              nimbocinol + 0
                                              nimolicinol 0
                                              ocotillone 0
                                              omaveloxolone 6
                                              paraherquonin 0
                                              piperitone + 0
                                              preaustinoid A 0
                                              preaustinoid A1 0
                                              preaustinoid A2 0
                                              protoaustinoid A 0
                                              protoaustinoid B 0
                                              rubiarbonone A 0
                                              rubiarbonone B 0
                                              rubiarbonone C 2
                                              rubiarbonone E 19-acetate 0
                                              rubiyunnanol C 0
                                              shionone 0
                                              sugiol + 0
                                              terretonin 0
                                              thujone + 4
                                              triptobenzene A 0
                                              triptohypol A 0
                                              triptohypol B 0
                                              triptonolide 0
                                              triptonoterpene 0
                                              triptoquinone A 0
                                              triptoquinone B 0
                                              triptoquinone H 0
                                              vibsanin B 0
                                              virgatic acid 0
                                              wilforic acid C 0
                                              wilforol A 0
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