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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pyridinedicarboxylic acid
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Accession:CHEBI:36112 term browser browse the term
Definition:Any member of the class of pyridines carrying two carboxy groups.
Synonyms:related_synonym: Formula=C7H5NO4;   pyridinedicarboxylic acids


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dipicolinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Glud1 glutamate dehydrogenase 1 multiple interactions
decreases activity
ISO dipicolinic acid inhibits the reaction [[GLUD1 protein co-treated with Ketoglutaric Acids co-treated with NADP co-treated with Aminooxyacetic Acid] affects the reaction [Carbon Tetrachloride affects the abundance of Ammonia]]
dipicolinic acid results in decreased activity of GLUD1 protein
CTD PMID:26639393 NCBI chr16:10,661,486...10,695,557
Ensembl chr16:10,662,021...10,695,557
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO dipicolinic acid promotes the reaction [MAPT protein binds to MAPT protein] CTD PMID:31678113 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
quinolinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acmsd aminocarboxymuconate semialdehyde decarboxylase affects abundance EXP ACMSD protein affects the abundance of Quinolinic Acid CTD PMID:17896587 NCBI chr13:44,424,689...44,468,734
Ensembl chr13:44,424,689...44,468,734
JBrowse link
G Ahr aryl hydrocarbon receptor increases activity ISO Quinolinic Acid results in increased activity of AHR protein CTD PMID:28336214 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
EXP Quinolinic Acid results in increased expression of BAX mRNA
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of BAX mRNA]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of BAX mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of BAX mRNA]
CTD PMID:30130594 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
EXP Quinolinic Acid results in decreased expression of BCL2 mRNA
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in decreased expression of BCL2 mRNA]; naringin inhibits the reaction [Quinolinic Acid results in decreased expression of BCL2 mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in decreased expression of BCL2 mRNA]
CTD PMID:30130594 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP Quinolinic Acid results in increased expression of BDNF mRNA CTD PMID:15698628 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
EXP Quinolinic Acid results in increased expression of CASP3 mRNA
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of CASP3 mRNA]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of CASP3 mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of CASP3 mRNA]
CTD PMID:30130594 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions
decreases activity
decreases expression
EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [pioglitazone inhibits the reaction [Quinolinic Acid results in decreased activity of CAT protein]]; nimesulide inhibits the reaction [Quinolinic Acid results in decreased expression of CAT protein]; pioglitazone inhibits the reaction [Quinolinic Acid results in decreased activity of CAT protein]; rofecoxib inhibits the reaction [Quinolinic Acid results in decreased expression of CAT protein] CTD PMID:20043943, PMID:20450929 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Chat choline O-acetyltransferase multiple interactions
decreases activity
EXP Dizocilpine Maleate inhibits the reaction [Quinolinic Acid results in decreased activity of CHAT protein] CTD PMID:2976130 NCBI chr16:8,576,858...8,686,131
Ensembl chr16:8,577,840...8,686,131
JBrowse link
G Cp ceruloplasmin multiple interactions EXP [Copper Sulfate co-treated with Quinolinic Acid] results in increased activity of CP protein CTD PMID:12899943 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
JBrowse link
G Dpp3 dipeptidylpeptidase 3 multiple interactions EXP Quinolinic Acid promotes the reaction [DPP3 protein binds to KEAP1 protein] CTD PMID:30876764 NCBI chr 1:220,166,124...220,189,762
Ensembl chr 1:220,166,127...220,188,541
JBrowse link
G Drd1 dopamine receptor D1 decreases expression EXP Quinolinic Acid results in decreased expression of DRD1 protein CTD PMID:12207953 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Drd2 dopamine receptor D2 increases expression EXP Quinolinic Acid results in increased expression of DRD2 protein CTD PMID:12207953 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 multiple interactions EXP GW 506033X inhibits the reaction [Quinolinic Acid results in increased expression of and results in increased cleavage of EIF2AK2 protein]; Quinolinic Acid results in increased expression of and results in increased cleavage of EIF2AK2 protein CTD PMID:24211709 NCBI chr 6:1,428,845...1,466,193
Ensembl chr 6:1,428,834...1,466,201
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation
multiple interactions
EXP Quinolinic Acid results in increased phosphorylation of EIF2S1 protein
[Quinolinic Acid co-treated with GW 506033X] results in increased phosphorylation of EIF2S1 protein
CTD PMID:24211709 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Fgf1 fibroblast growth factor 1 decreases secretion ISO Quinolinic Acid results in decreased secretion of FGF1 protein CTD PMID:16392031 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Quinolinic Acid results in increased expression of FOS mRNA CTD PMID:15698628 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity EXP Quinolinic Acid results in increased activity of G6PD protein CTD PMID:30876764 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
EXP Quinolinic Acid results in increased expression of IL1B mRNA; Quinolinic Acid results in increased expression of IL1B protein
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of IL1B mRNA]; GW 506033X inhibits the reaction [Quinolinic Acid results in increased expression of IL1B protein]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of IL1B mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of IL1B mRNA]
CTD PMID:24211709, PMID:30130594 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
EXP [naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of IL6 mRNA]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of IL6 mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of IL6 mRNA] CTD PMID:30130594 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions EXP Quinolinic Acid promotes the reaction [DPP3 protein binds to KEAP1 protein]; Quinolinic Acid promotes the reaction [SQSTM1 protein binds to KEAP1 protein]; Quinolinic Acid results in increased expression of and affects the localization of KEAP1 protein CTD PMID:30876764 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Quinolinic Acid promotes the reaction [MAPT protein binds to MAPT protein] CTD PMID:31678113 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP Quinolinic Acid results in increased activity of and affects the localization of NFE2L2 protein CTD PMID:30876764 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
decreases expression
EXP [naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in decreased expression of PPARG mRNA]; naringin inhibits the reaction [Quinolinic Acid results in decreased expression of PPARG mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in decreased expression of PPARG mRNA] CTD PMID:30130594 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppif peptidylprolyl isomerase F increases response to substance ISO PPIF results in increased susceptibility to Quinolinic Acid CTD PMID:21378209 NCBI chr16:1,979,191...1,985,912
Ensembl chr16:1,979,191...1,985,908
JBrowse link
G Rgs2 regulator of G-protein signaling 2 decreases expression EXP Quinolinic Acid results in decreased expression of RGS2 mRNA; Quinolinic Acid results in decreased expression of RGS2 protein CTD PMID:12207953 NCBI chr13:60,846,458...60,849,061
Ensembl chr13:60,846,308...60,849,094
JBrowse link
G Slc6a3 solute carrier family 6 member 3 decreases expression
increases expression
EXP Quinolinic Acid results in decreased expression of SLC6A3 protein
Quinolinic Acid results in increased expression of SLC6A3 protein
CTD PMID:12207953 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Sod1 superoxide dismutase 1 decreases activity
multiple interactions
EXP Quinolinic Acid results in decreased activity of SOD1 protein
Copper Sulfate inhibits the reaction [Quinolinic Acid results in decreased activity of SOD1 protein]
CTD PMID:12899943 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP Quinolinic Acid promotes the reaction [SQSTM1 protein binds to KEAP1 protein] CTD PMID:30876764 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of TNF protein]]; [naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of TNF mRNA]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of TNF mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of TNF mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of TNF protein]
Quinolinic Acid results in increased expression of TNF mRNA; Quinolinic Acid results in increased expression of TNF protein
CTD PMID:20450929, PMID:30130594 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      chemical role 19288
        environmental contaminant 18613
          pyridine 50
            pyridinedicarboxylic acid 30
              cinchomeronic acid + 0
              dinicotinic acid 0
              dipicolinic acid + 2
              isocinchomeronic acid 0
              lutidinic acid 0
              quinolinic acid 29
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      dicarboxylic acids and O-substituted derivatives 10279
                                        dicarboxylic acid 10272
                                          pyridinedicarboxylic acid 30
                                            cinchomeronic acid + 0
                                            dinicotinic acid 0
                                            dipicolinic acid + 2
                                            isocinchomeronic acid 0
                                            lutidinic acid 0
                                            quinolinic acid 29
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.