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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:hydroxy monocarboxylic acid anion
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Accession:CHEBI:36059 term browser browse the term
Definition:Any monocarboxylic acid anion carrying at least one hydroxy substituent.
Synonyms:related_synonym: hydroxy monocarboxylic acid anions;   hydroxymonocarboxylic acid anion;   hydroxymonocarboxylic acid anions
 cyclic_relationship: is_conjugate_base_of CHEBI:35868


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3,4-dihydroxybenzoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Epas1 endothelial PAS domain protein 1 increases expression
multiple interactions		 ISO 3,4-dihydroxybenzoate results in increased expression of EPAS1 mRNA
[3,4-dihydroxybenzoate co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EPAS1 mRNA		 CTD PMID:19679656 NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression
affects localization
multiple interactions		 ISO
EXP		 3,4-dihydroxybenzoate results in increased expression of HIF1A mRNA
3,4-dihydroxybenzoate affects the localization of HIF1A protein
[3,4-dihydroxybenzoate co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine metabolite] affects the localization of HIF1A protein
[3,4-dihydroxybenzoate co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HIF1A mRNA		 CTD PMID:19679656 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO [3,4-dihydroxybenzoate co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HMOX1 mRNA; [3,4-dihydroxybenzoate co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HMOX1 protein
3,4-dihydroxybenzoate results in increased expression of HMOX1 mRNA; 3,4-dihydroxybenzoate results in increased expression of HMOX1 protein		 CTD PMID:19679656 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Slc40a1 solute carrier family 40 member 1 multiple interactions ISO 3,4-dihydroxybenzoate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC40A1 protein] CTD PMID:19679656 NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression		 ISO [3,4-dihydroxybenzoate co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SOD2 protein
3,4-dihydroxybenzoate results in increased expression of SOD2 protein		 CTD PMID:19679656 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
lobaplatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc2 baculoviral IAP repeat-containing 2 increases degradation ISO Lobaplatin increases degradation of BIRC2 protein in human nasopharyngeal carcinoma cells RGD PMID:32413426 RGD:155226873 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 increases degradation ISO Lobaplatin increases degradation of BIRC3 protein in human nasopharyngeal carcinoma cells RGD PMID:32413426 RGD:155226873 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
physostigmine salicylate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO physostigmine salicylate results in decreased activity of ACHE protein CTD PMID:623676 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
pitavastatin(1-) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions
increases expression		 EXP
ISO		 GW 6471 inhibits the reaction [pitavastatin results in increased expression of ABCA1 mRNA]
pitavastatin inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in increased expression of ABCA1 protein]
GW 6471 inhibits the reaction [pitavastatin results in increased expression of ABCA1 mRNA]; PPARA protein affects the reaction [pitavastatin results in increased expression of ABCA1 mRNA]		 CTD PMID:16415093 PMID:21554872 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity		 ISO pitavastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]; pitavastatin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
pitavastatin results in decreased activity of ABCB11 protein		 CTD PMID:15901796 PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects transport ISO ABCB1 protein affects the transport of pitavastatin CTD PMID:15955871 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
affects transport		 EXP
ISO		 ABCC2 protein binds to and results in increased uptake of pitavastatin analog; pitavastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]
ABCC2 protein affects the transport of pitavastatin		 CTD PMID:15955871 PMID:23562342 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 affects transport ISO ABCG2 protein affects the transport of pitavastatin CTD PMID:15955871 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression		 ISO EIF2AK3 protein affects the reaction [pitavastatin results in increased expression of ATF4 protein] CTD PMID:37956312 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions
increases expression
affects response to substance		 ISO BBC3 protein affects the susceptibility to [S63845 co-treated with pitavastatin]; BBC3 protein affects the susceptibility to [venetoclax co-treated with pitavastatin]
pitavastatin results in increased expression of BBC3 mRNA; pitavastatin results in increased expression of BBC3 protein
BBC3 protein affects the susceptibility to pitavastatin		 CTD PMID:37956312 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of CCL2 mRNA]; pitavastatin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA] CTD PMID:18323514 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO EIF2AK3 protein affects the reaction [pitavastatin results in increased expression of ATF4 protein] CTD PMID:37956312 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Foxo1 forkhead box O1 decreases phosphorylation ISO pitavastatin results in decreased phosphorylation of FOXO1 protein CTD PMID:33034787 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO pitavastatin inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; pitavastatin inhibits the reaction [Palmitic Acid results in increased expression of IFNB1 mRNA]; pitavastatin inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA] CTD PMID:18323514 NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of IL6 mRNA]; pitavastatin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; pitavastatin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; pitavastatin inhibits the reaction [Palmitic Acid results in increased expression of IL6 mRNA]; pitavastatin inhibits the reaction [Poly I-C results in increased expression of IL6 mRNA] CTD PMID:18323514 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions ISO pitavastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRF3 protein]; pitavastatin inhibits the reaction [Palmitic Acid results in increased phosphorylation of IRF3 protein] CTD PMID:18323514 NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935 		JBrowse link
G Irf4 interferon regulatory factor 4 decreases expression ISO pitavastatin results in decreased expression of IRF4 protein CTD PMID:33034787 NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070 		JBrowse link
G Lep leptin multiple interactions ISO pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of CCL2 mRNA]; pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of IL6 mRNA]; pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of TNF mRNA] CTD PMID:18323514 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Mstn myostatin increases expression ISO pitavastatin results in increased expression of MSTN protein CTD PMID:33034787 NCBI chr 9:48,452,533...48,458,933
Ensembl chr 9:48,452,533...48,458,933 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO pitavastatin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; pitavastatin inhibits the reaction [Palmitic Acid results in increased expression of NOS2 mRNA]; pitavastatin inhibits the reaction [Poly I-C results in increased expression of NOS2 mRNA] CTD PMID:18323514 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 multiple interactions ISO NR1H2 gene mutant form inhibits the reaction [pitavastatin inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in increased export of Cholesterol]]; NR1H2 gene mutant form inhibits the reaction [pitavastatin results in decreased export of Cholesterol] CTD PMID:16415093 NCBI chr 1:95,041,967...95,047,358
Ensembl chr 1:95,041,967...95,047,377 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions ISO NR1H3 gene mutant form inhibits the reaction [pitavastatin inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in increased export of Cholesterol]]; NR1H3 gene mutant form inhibits the reaction [pitavastatin results in decreased export of Cholesterol] CTD PMID:16415093 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO pitavastatin results in increased cleavage of PARP1 protein CTD PMID:37956312 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 multiple interactions
increases expression		 ISO 2-(4-chlorophenoxy)-N-(4-(2-(4-chlorophenoxy)acetamido)cyclohexyl)acetamide inhibits the reaction [pitavastatin results in increased expression of PMAIP1 protein] CTD PMID:37956312 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Pon1 paraoxonase 1 multiple interactions
increases expression		 ISO farnesyl pyrophosphate inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA]; Mevalonic Acid inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA]; Plicamycin inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA] CTD PMID:15690306 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases expression		 ISO pitavastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]; PPARA protein affects the reaction [pitavastatin results in increased expression of ABCA1 mRNA]
pitavastatin results in increased expression of PPARA mRNA		 CTD PMID:11779144 PMID:21554872 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases expression ISO pitavastatin results in increased expression of PPARD mRNA CTD PMID:21554872 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968 		JBrowse link
G Rap1a RAP1A, member of RAS oncogene family decreases prenylation
decreases expression		 ISO pitavastatin results in decreased prenylation of RAP1A protein
pitavastatin results in decreased expression of RAP1A protein alternative form		 CTD PMID:37956312 NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501 		JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO pitavastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]] CTD PMID:11779144 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects transport ISO SLCO1A4 protein affects the transport of pitavastatin CTD PMID:19833843 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO pitavastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein] CTD PMID:18323514 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of TNF mRNA]; pitavastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:18323514 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
rosuvastatin calcium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 decreases expression
multiple interactions		 ISO Rosuvastatin Calcium results in decreased expression of ABCA1 mRNA
Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of ABCA1 mRNA]		 CTD PMID:18192897 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO
EXP		 Rosuvastatin Calcium inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]
[Cyclosporine results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium; [Glyburide results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium; [troglitazone results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium		 CTD PMID:15901796 PMID:19853032 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
affects secretion
increases expression		 ISO
EXP		 ABCC2 protein binds to and results in increased uptake of Rosuvastatin Calcium analog; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]
ABCC2 protein affects the secretion of Rosuvastatin Calcium
[Benzbromarone results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; [Probenecid results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; [Sulfasalazine results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; ABCC2 protein binds to and results in increased uptake of Rosuvastatin Calcium analog; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Rosuvastatin Calcium promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]
Rosuvastatin Calcium results in increased expression of ABCC2 protein		 CTD PMID:19853032 PMID:23562342 PMID:24909372 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Rosuvastatin Calcium results in increased expression of ABCC3 protein CTD PMID:24909372 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 decreases expression ISO Rosuvastatin Calcium results in decreased expression of ABCG1 mRNA CTD PMID:18192897 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases activity		 EXP
ISO		 [Novobiocin results in decreased activity of ABCG2 protein] which results in decreased secretion of Rosuvastatin Calcium
Rosuvastatin Calcium results in increased activity of ABCG2 protein		 CTD PMID:19853032 PMID:30083819 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Ache acetylcholinesterase multiple interactions EXP [Piracetam co-treated with Rosuvastatin Calcium] inhibits the reaction [[Sodium Chloride, Dietary co-treated with Cholesterol, Dietary co-treated with Coconut Oil] results in increased activity of ACHE protein]; Rosuvastatin Calcium inhibits the reaction [[Sodium Chloride, Dietary co-treated with Cholesterol, Dietary co-treated with Coconut Oil] results in increased activity of ACHE protein] CTD PMID:28441890 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects phosphorylation EXP Rosuvastatin Calcium affects the phosphorylation of AKT1 protein CTD PMID:27815113 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions
increases expression		 ISO Niacin promotes the reaction [Rosuvastatin Calcium results in increased expression of APOA1 protein] CTD PMID:12767421 PMID:15539964 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Apob apolipoprotein B decreases expression ISO Rosuvastatin Calcium results in decreased expression of APOB protein CTD PMID:15539964 PMID:18702965 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of BAX mRNA] CTD PMID:32007421 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Rosuvastatin Calcium results in decreased expression of BCL2 protein CTD PMID:20852871 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G C3 complement C3 decreases expression ISO Rosuvastatin Calcium results in decreased expression of C3 mRNA CTD PMID:32771489 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G Casp3 caspase 3 increases activity
increases expression		 ISO Rosuvastatin Calcium results in increased activity of CASP3 protein
Rosuvastatin Calcium results in increased expression of CASP3 protein		 CTD PMID:21478229 PMID:32771489 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase increases activity
multiple interactions		 EXP Rosuvastatin Calcium results in increased activity of CAT protein
[Rosuvastatin Calcium co-treated with Isoproterenol] inhibits the reaction [Interleukin-6 results in increased expression of CAT protein]; Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]		 CTD PMID:20146376 PMID:32007421 PMID:35130744 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression EXP Rosuvastatin Calcium results in decreased expression of CCL2 mRNA CTD PMID:15681303 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Creb5 cAMP responsive element binding protein 5 decreases expression ISO Rosuvastatin Calcium results in decreased expression of CREB5 mRNA CTD PMID:18192897 NCBI chr 4:82,393,091...82,794,320
Ensembl chr 4:82,393,730...82,790,325 		JBrowse link
G Crp C-reactive protein multiple interactions ISO Rosuvastatin Calcium inhibits the reaction [CRP protein results in decreased expression of NOS3] CTD PMID:21562509 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions
decreases expression		 EXP [[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species CTD PMID:21562509 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions
decreases expression		 ISO
EXP		 Rosuvastatin Calcium inhibits the reaction [Nitroglycerin results in increased expression of CYBB mRNA]
Rosuvastatin Calcium results in decreased expression of CYBB
[[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species		 CTD PMID:16633368 PMID:21562509 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO Rosuvastatin Calcium results in decreased expression of ESR1 protein CTD PMID:32771489 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions		 ISO Rosuvastatin Calcium results in increased expression of GCLC mRNA
[Tetradecanoylphorbol Acetate co-treated with Rosuvastatin Calcium] results in increased expression of GCLC mRNA		 CTD PMID:18154958 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gpr183 G protein-coupled receptor 183 multiple interactions
increases expression		 ISO Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in increased expression of GPR183 mRNA] CTD PMID:18192897 NCBI chr15:99,037,764...99,050,550
Ensembl chr15:99,036,367...99,050,559 		JBrowse link
G Gzmk granzyme K multiple interactions
increases expression		 ISO Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in increased expression of GZMK mRNA] CTD PMID:18192897 NCBI chr 2:44,840,811...44,848,829
Ensembl chr 2:44,840,811...44,848,894 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha increases secretion ISO HNF4A protein results in increased secretion of Rosuvastatin Calcium CTD PMID:27160211 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320 		JBrowse link
G Il18rap interleukin 18 receptor accessory protein decreases expression
multiple interactions		 ISO Rosuvastatin Calcium results in decreased expression of IL18RAP mRNA
Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of IL18RAP mRNA]		 CTD PMID:18192897 NCBI chr 9:42,768,112...42,800,964
Ensembl chr 9:42,768,220...42,800,959 		JBrowse link
G Il1b interleukin 1 beta decreases expression EXP Rosuvastatin Calcium results in decreased expression of IL1B mRNA CTD PMID:15681303 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Rosuvastatin Calcium results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Kcnj15 potassium inwardly-rectifying channel, subfamily J, member 15 decreases expression ISO Rosuvastatin Calcium results in decreased expression of KCNJ15 mRNA CTD PMID:18192897 NCBI chr11:34,577,397...34,621,725
Ensembl chr11:34,577,363...34,621,952 		JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of KDR protein] CTD PMID:27097221 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Mb myoglobin affects expression EXP Rosuvastatin Calcium affects the expression of MB protein CTD PMID:27815113 NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383 		JBrowse link
G Mstn myostatin increases expression ISO Rosuvastatin Calcium results in increased expression of MSTN protein CTD PMID:33034787 NCBI chr 9:48,452,533...48,458,933
Ensembl chr 9:48,452,533...48,458,933 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in decreased expression of NFE2L2 mRNA] CTD PMID:32007421 PMID:35130744 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions		 EXP Rosuvastatin Calcium results in increased expression of NOS2 mRNA
Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of NOS2 mRNA]		 CTD PMID:21443142 PMID:32007421 PMID:35130744 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
affects response to substance
increases expression		 ISO
EXP		 Rosuvastatin Calcium inhibits the reaction [CRP protein results in decreased expression of NOS3]; Rosuvastatin Calcium results in increased phosphorylation of and results in increased activity of NOS3 protein
NOS3 protein affects the susceptibility to Rosuvastatin Calcium
Rosuvastatin Calcium results in increased expression of NOS3 mRNA		 CTD PMID:12354446 PMID:15681303 PMID:18162361 PMID:21562509 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Orm1 orosomucoid 1 multiple interactions
decreases expression		 ISO Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of ORM1 mRNA] CTD PMID:18192897 NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 multiple interactions ISO Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of PECAM1 protein] CTD PMID:27097221 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Selp selectin P decreases expression EXP Rosuvastatin Calcium results in decreased expression of SELP mRNA CTD PMID:15681303 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845 		JBrowse link
G Serpine2 serpin family E member 2 multiple interactions ISO Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SERPINE2 protein]; Rosuvastatin Calcium inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein] CTD PMID:27097221 NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions
affects transport
decreases expression
increases uptake		 EXP
ISO		 Fusidic Acid inhibits the reaction [SLCO1A4 protein results in increased uptake of Rosuvastatin Calcium]
SLCO1A4 protein affects the transport of Rosuvastatin Calcium
Rosuvastatin Calcium results in decreased expression of SLCO1A4 protein
SLCO1A2 protein results in increased uptake of Rosuvastatin Calcium
diosmetin inhibits the reaction [SLCO1A2 protein results in increased uptake of Rosuvastatin Calcium]		 CTD PMID:19833843 PMID:24909372 PMID:26888941 PMID:28867436 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions
increases uptake		 EXP
ISO		 Fusidic Acid inhibits the reaction [SLCO1B2 protein results in increased uptake of Rosuvastatin Calcium]
SLCO1B3 protein results in increased uptake of Rosuvastatin Calcium
Fusidic Acid inhibits the reaction [SLCO1B3 protein results in increased uptake of Rosuvastatin Calcium]		 CTD PMID:26888941 PMID:31299240 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 increases uptake
multiple interactions		 ISO SLCO2B1 protein results in increased uptake of Rosuvastatin Calcium
Rutin promotes the reaction [SLCO2B1 protein results in increased uptake of Rosuvastatin Calcium]		 CTD PMID:24285294 NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression		 EXP [[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species CTD PMID:21562509 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Tff1 trefoil factor 1 decreases expression ISO Rosuvastatin Calcium results in decreased expression of TFF1 mRNA CTD PMID:32771489 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression		 ISO
EXP		 Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TGFB1 protein]; Rosuvastatin Calcium inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]
Rosuvastatin Calcium results in decreased expression of TGFB1 mRNA		 CTD PMID:15681303 PMID:27097221 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions		 EXP Rosuvastatin Calcium results in decreased expression of TNF mRNA
Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of TNF protein]		 CTD PMID:15681303 PMID:32007421 PMID:35130744 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions EXP Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of TNNI3 protein] CTD PMID:32007421 PMID:35130744 NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580 		JBrowse link
G Vnn3 vanin 3 decreases expression ISO Rosuvastatin Calcium results in decreased expression of VNN3P mRNA CTD PMID:18192897 NCBI chr 1:21,571,364...21,583,626
Ensembl chr 1:21,571,364...21,583,626 		JBrowse link
G Wt1 WT1 transcription factor increases expression EXP Rosuvastatin Calcium results in increased expression of WT1 mRNA CTD PMID:21443142 NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    chemical entity 19919
      molecular entity 19919
        ion 17100
          anion 16649
            organic anion 6851
              carboxylic acid anion 2500
                monocarboxylic acid anion 1605
                  hydroxy monocarboxylic acid anion 76
                    (+)-8'-hydroxyabscisate 0
                    (-)-ureidoglycolate 0
                    (1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate 0
                    (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate 0
                    (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate 0
                    (2,6-dihydroxyphenyl)acetate 0
                    (2E,4E)-3,8,8,8-tetrachloro-7-(4-chlorophenyl)-2-hydroxy-6-oxo-octa-2,4-dienoate 0
                    (2E,4Z)-2-hydroxy-6-oxoocta-2,4,7-trienoate 0
                    (2E,4Z)-2-hydroxy-7-methyl-6-oxo-2,4-octadienoate 0
                    (2R)-2-hydroxy monocarboxylic acid anion + 0
                    (2R)-2-hydroxy-4-(methylsulfanyl)butanoate 0
                    (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate 0
                    (2R,3R)-2,3-dihydroxy-3-methylpentanoate 0
                    (2R,3S)-2-alkyl-3-hydroxyalkanoate 0
                    (2S)-2-hydroxy monocarboxylic acid anion + 0
                    (2S)-2-hydroxy-2-methyl-3-oxobutanoate 0
                    (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate 0
                    (2Z,4Z)-3,8,8-trichloro-7-(4-chlorophenyl)-2-hydroxy-6-oxoocta-2,4,7-trienoate 0
                    (3,4-dihydroxyphenyl)acetate 0
                    (3,5-dihydroxyphenyl)acetate 0
                    (3R)-3-\{[(3R)-3-\{[(3R)-3-\{[(3R)-3-\{[(3R)-3-hydroxybutanoyl]oxy\}butanoyl]oxy\}butanoyl]oxy\}butanoyl]oxy\}butanoate 0
                    (3R)-3-\{[(3R)-3-\{[(3R)-3-\{[(3R)-3-hydroxybutanoyl]oxy\}butanoyl]oxy\}butanoyl]oxy\}butanoate 0
                    (3R)-3-\{[(3R)-3-\{[(3R)-3-hydroxybutanoyl]oxy\}butanoyl]oxy\}butanoate 0
                    (3R,4R)-3,4-dihydroxycyclohexa-1,5-diene-1-carboxylate 0
                    (4E,6E)-3-hydroxydeca-4,6-dienoate 0
                    (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate 0
                    (5Z,9E,12S,14Z)-8,11,12-trihydroxyicosa-5,9,14-trienoate 0
                    (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate 0
                    (9S,10R)-10-hydroxy-9-(phosphonatooxy)octadecanoate 0
                    (9S,10S)-10-hydroxy-9-(phosphonatooxy)octadecanoate 0
                    (E)-caffeoylpyruvate 0
                    (R)-10-hydroxyoctadecanoate 0
                    (R)-2,4-dihydroxy-3-oxobutanoate 0
                    (R)-2-hydroxy-3-methylbutyrate 0
                    (R)-2-hydroxy-3-oxo-4-(phosphonatooxy)butanoate(3-) 0
                    (R)-2-hydroxy-4-(hydroxymethylphosphinyl)butyrate 0
                    (R)-2-hydroxy-4-methylpentanoate 0
                    (R)-2-hydroxynonanoate 0
                    (R)-3,4-dihydroxy-2-oxobutanoate 0
                    (R)-3-(5-benzyloxyindol-3-yl)lactate 0
                    (R)-3-[(R)-3-hydroxybutanoyloxy]butanoate 0
                    (R)-3-phosphonatomevalonate(3-) 0
                    (R)-4-dehydropantoate 0
                    (R)-4-phosphonatopantoate(3-) 0
                    (R)-5-phosphonatomevalonate(3-) 0
                    (R)-indole-3-lactate 0
                    (R)-pantoate 0
                    (S)-2,4-dihydroxy-3-oxobutanoate 0
                    (S)-2-acetyl-2-hydroxybutanoate 0
                    (S)-2-hydroxy-3-methylbutyrate 0
                    (S)-2-hydroxy-3-oxo-4-(phosphonatooxy)butanoate(3-) 0
                    (S)-3,4-dihydroxy-2-oxobutanoate 0
                    (S)-3-(imidazol-5-yl)lactate 0
                    (S)-3-fluorolactate 0
                    (S)-3-hydroxy-2-oxo-3-phenylpropanoate 0
                    (S)-4-hydroxy-1-pyrroline-2-carboxylate 0
                    (S,S)-9,10-dihydroxyoctadecanoate 0
                    1,4-dihydroxy-2-naphthoate + 0
                    1-deoxy-11beta-hydroxypentalenate 0
                    1-hydroxy-2-naphthoate 0
                    11-hydroxyjasmonate 0
                    12,20-dioxoleukotriene B4(1-) 0
                    12-hydroxyjasmonates + 0
                    13-hydroxydocosanoate 0
                    2,3-dihydroxy-2,3-dihydrobenzoate 0
                    2,3-dihydroxy-2-methylpropanoate 0
                    2,3-dihydroxy-3-methylbutanoate + 0
                    2,3-diketogulonate 0
                    2,4-dihydroxy-5-methyl-6-oxo-2,4-hexadienoate + 0
                    2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate 0
                    2-(alpha-D-mannosyl)-3-phosphonatoglycerate(3-) 0
                    2-(beta-D-glucosyloxy)-cis-cinnamate 0
                    2-(hydroxymethyl)-4-oxobutanoate 0
                    2-O-(alpha-D-glucopyranosyl)-D-glycerate 0
                    2-O-[6-O-octanoyl-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl]-D-glycerate 0
                    2-O-[alpha-D-glucosyl-(1->6)-alpha-D-glucosyl]-D-glycerate 0
                    2-acetyllactate 0
                    2-carbonyl-3-prenyl-1,4-naphthoquinone + 0
                    2-hydroxy carboxylate + 0
                    2-hydroxy-3-methylbutyrate 0
                    2-hydroxy-3-oxopropanoate 0
                    2-hydroxy-6-(2-oxidophenyl)-6-oxo-cis,cis-hexa-2,4-dienoate(2-) 0
                    2-hydroxy-6-oxo-2,4-heptadienoate + 0
                    2-hydroxy-6-oxo-7-methylocta-2,4-dienoate 0
                    2-hydroxy-6-oxo-nona-2,4-dienoate 0
                    2-hydroxy-6-oxohexa-2,4-dienoate + 0
                    2-hydroxy-6-oxoocta-2,4-dienoate 0
                    2-hydroxyibuprofen(1-) 0
                    2-hydroxypentanoate 0
                    2-phosphonato-D-glycerate(3-) 0
                    2-prenyl-1,4-naphthoquinone 0
                    20-hydroxy-leukotriene B4(1-) 0
                    20-oxoleukotriene B4(1-) 0
                    3,4-dihydroxymandelate + 0
                    3,5-dihydroxy-3-methylpentanoate + 0
                    3-(3,4-dihydroxyphenyl)lactate + 0
                    3-(4-hydroxyphenyl)lactate + 0
                    3-(6-hydroxyindol-3-yl)lactate 0
                    3-(imidazol-5-yl)lactate 0
                    3-ADP-glycerate(3-) 0
                    3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1,5-dioxo-octahydroinden-4-yl]propanoate 0
                    3-[(5R,6S)-5,6-dihydroxycyclohexa-1,3-dienyl]acrylate + 0
                    3-[(5S,6R)-5,6-dihydroxycyclohexa-1,3-dienyl]acrylate + 0
                    3-dehydroquinate 0
                    3-dimethylallyl-4-hydroxymandelate 0
                    3-hydroxy-3-methyl-2-oxobutanoate 0
                    3-hydroxy-3-methyl-2-oxopentanoate + 0
                    3-hydroxy-3-methylhexanoate 0
                    3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + 0
                    3-hydroxy-5-oxohexanoate + 0
                    3-hydroxydecanoyl-3-hydroxydecanoate + 0
                    3-hydroxyhexanoate 0
                    3-hydroxyisobutyrate + 0
                    3-hydroxyisovalerate 0
                    3-hydroxyphenylacetate 0
                    3-hydroxypropionate 0
                    3-hydroxypyruvate 0
                    3-oxoisoapionate + 0
                    3-oxoisoapionate 4-phosphate(2-) + 0
                    3-phosphonato-D-glycerate(3-) 0
                    3-phosphonatoshikimate(3-) 0
                    3-sulfonatolactate(2-) + 0
                    3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate 0
                    3alpha-hydroxy-3,5-dihydromonacolin L carboxylate 0
                    4-O-beta-D-glucosyl-trans-caffeate 0
                    4-O-feruloyl-D-quinate 0
                    4-O-phosphonato-D-erythronate(3-) 0
                    4-O-phosphonato-D-threonate(3-) 0
                    4-amino-3-hydroxybutanoate 0
                    4-coumaroylshikimate 0
                    4-hydroxy monocarboxylic acid anion + 0
                    4-hydroxy-1-pyrroline-2-carboxylate 0
                    4-hydroxy-2-oxopentanoate + 0
                    4-hydroxy-all-trans-13,14-dihydroretinoate 0
                    4a,5-dihydro-ML-236C carboxylate 0
                    5-[(E)-caffeoyl]shikimate 0
                    5-hydroxy-2,4-dioxopentanoate 0
                    5-hydroxypentanoate + 0
                    6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + 0
                    6-hydroxyphenazine-1-carboxylate 0
                    6-phosphonato-5-dehydro-2-deoxy-D-gluconate(3-) 0
                    7(S),8(S)-DiHODE(1-) 0
                    7,8-dihydro-7,8-dihydroxykynurenate 0
                    7,8-dihydroxykynurenate 0
                    9-cis-4-hydroxyretinoate 0
                    9-riburonosylhypoxanthine(1-) 0
                    D-apionate 0
                    Delta(9)-tetrahydrocannabinolate 0
                    L-threonate 0
                    ML-236A carboxylate 0
                    ML-236C carboxylate 0
                    N-[(9-beta-D-ribofuranosylpurin-6-yl)carbamoyl]threonate 0
                    N-acetyl-D-muramoyl-L-alaninate + 0
                    N-adenylylanthranilate 0
                    SN-38 carboxylate 0
                    [(1S)-4-hydroxy-2,2,3-trimethylcyclopent-3-enyl]acetate 0
                    all-trans-16-hydroxyretinoate 0
                    all-trans-18-hydroxyretinoate 0
                    all-trans-4,16-dihydroxyretinoate 0
                    all-trans-4,18-dihydroxyretinoate 0
                    all-trans-4-hydroxyretinoate + 0
                    all-trans-4-oxo-16-hydroxyretinoate 0
                    all-trans-4-oxo-18-hydroxyretinoate 0
                    atrochrysone carboxylate 0
                    cannabichromenate 0
                    cerivastatin(1-) + 0
                    cis,cis-2-hydroxy-6-oxohepta-2,4-dienoate 0
                    cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate(2-) 0
                    cis-4-coumarate 0
                    cis-4-hydroxycyclohexane-1-carboxylate 0
                    cis-5,6-dihydroxy-4-isopropylcyclohexa-1,3-dienecarboxylate 0
                    cis-caffeate 0
                    demethylsulochrin(1-) 0
                    demethylsulochrin(2-) 0
                    dihydromonacolin L carboxylate 0
                    enol-phenylpyruvate 0
                    erythronate + 0
                    glycerate + 0
                    glycolate + 0
                    hainanate A 0
                    hexacyclonate + 0
                    homogentisate 0
                    homovanillate 0
                    hydroxy fatty acid anion + 0
                    hydroxybenzoate + 6
                    lactate + 2
                    leukotriene B4(1-) 0
                    mandelate + 0
                    mevaldate + 0
                    mevinic acid anion 0
                    mevinolinate 0
                    monacolin J carboxylate 0
                    monacolin L carboxylate 0
                    mutalomycin(1-) + 0
                    o-orsellinate depsidate(1-) 0
                    pentalenate 0
                    phloretate 0
                    pitavastatin(1-) + 29
                    rifamycin B(2-) 0
                    rosuvastatin(1-) + 49
                    sch 210971(2-) 0
                    sch 210972(2-) 0
                    shikimate + 0
                    soppiline A(1-) 0
                    soppiline C(1-) 0
                    sordaricin(1-) 0
                    stipitatate(1-) 0
                    stipitatate(2-) 0
                    tetracenomycin D3(1-) 0
                    tetracenomycin D3(2-) 0
                    tetracenomycin F1(1-) 0
                    tetracenomycin F2(1-) 0
                    tetracenomycin F2(2-) 0
                    trans-4-hydroxycyclohexanecarboxylate 0
                    trans-5-O-(4-coumaroyl)-D-quinate 0
                    trans-5-O-caffeoyl-D-quinate 0
                    trans-beta-D-glucosyl-2-hydroxycinnamate 0
                    trans-caffeate + 0
                    tropate 0
                    vanillylmandelate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19865
                    p-block element atom 19865
                      carbon group element atom 19804
                        carbon atom 19801
                          organic molecular entity 19801
                            organic ion 11448
                              organic anion 6851
                                carboxylic acid anion 2500
                                  monocarboxylic acid anion 1605
                                    hydroxy monocarboxylic acid anion 76
                                      (+)-8'-hydroxyabscisate 0
                                      (-)-ureidoglycolate 0
                                      (1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate 0
                                      (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate 0
                                      (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate 0
                                      (2,6-dihydroxyphenyl)acetate 0
                                      (2E,4E)-3,8,8,8-tetrachloro-7-(4-chlorophenyl)-2-hydroxy-6-oxo-octa-2,4-dienoate 0
                                      (2E,4Z)-2-hydroxy-6-oxoocta-2,4,7-trienoate 0
                                      (2E,4Z)-2-hydroxy-7-methyl-6-oxo-2,4-octadienoate 0
                                      (2R)-2-hydroxy monocarboxylic acid anion + 0
                                      (2R)-2-hydroxy-4-(methylsulfanyl)butanoate 0
                                      (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate 0
                                      (2R,3R)-2,3-dihydroxy-3-methylpentanoate 0
                                      (2R,3S)-2-alkyl-3-hydroxyalkanoate 0
                                      (2S)-2-hydroxy monocarboxylic acid anion + 0
                                      (2S)-2-hydroxy-2-methyl-3-oxobutanoate 0
                                      (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate 0
                                      (2Z,4Z)-3,8,8-trichloro-7-(4-chlorophenyl)-2-hydroxy-6-oxoocta-2,4,7-trienoate 0
                                      (3,4-dihydroxyphenyl)acetate 0
                                      (3,5-dihydroxyphenyl)acetate 0
                                      (3R)-3-\{[(3R)-3-\{[(3R)-3-\{[(3R)-3-\{[(3R)-3-hydroxybutanoyl]oxy\}butanoyl]oxy\}butanoyl]oxy\}butanoyl]oxy\}butanoate 0
                                      (3R)-3-\{[(3R)-3-\{[(3R)-3-\{[(3R)-3-hydroxybutanoyl]oxy\}butanoyl]oxy\}butanoyl]oxy\}butanoate 0
                                      (3R)-3-\{[(3R)-3-\{[(3R)-3-hydroxybutanoyl]oxy\}butanoyl]oxy\}butanoate 0
                                      (3R,4R)-3,4-dihydroxycyclohexa-1,5-diene-1-carboxylate 0
                                      (4E,6E)-3-hydroxydeca-4,6-dienoate 0
                                      (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate 0
                                      (5Z,9E,12S,14Z)-8,11,12-trihydroxyicosa-5,9,14-trienoate 0
                                      (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate 0
                                      (9S,10R)-10-hydroxy-9-(phosphonatooxy)octadecanoate 0
                                      (9S,10S)-10-hydroxy-9-(phosphonatooxy)octadecanoate 0
                                      (E)-caffeoylpyruvate 0
                                      (R)-10-hydroxyoctadecanoate 0
                                      (R)-2,4-dihydroxy-3-oxobutanoate 0
                                      (R)-2-hydroxy-3-methylbutyrate 0
                                      (R)-2-hydroxy-3-oxo-4-(phosphonatooxy)butanoate(3-) 0
                                      (R)-2-hydroxy-4-(hydroxymethylphosphinyl)butyrate 0
                                      (R)-2-hydroxy-4-methylpentanoate 0
                                      (R)-2-hydroxynonanoate 0
                                      (R)-3,4-dihydroxy-2-oxobutanoate 0
                                      (R)-3-(5-benzyloxyindol-3-yl)lactate 0
                                      (R)-3-[(R)-3-hydroxybutanoyloxy]butanoate 0
                                      (R)-3-phosphonatomevalonate(3-) 0
                                      (R)-4-dehydropantoate 0
                                      (R)-4-phosphonatopantoate(3-) 0
                                      (R)-5-phosphonatomevalonate(3-) 0
                                      (R)-indole-3-lactate 0
                                      (R)-pantoate 0
                                      (S)-2,4-dihydroxy-3-oxobutanoate 0
                                      (S)-2-acetyl-2-hydroxybutanoate 0
                                      (S)-2-hydroxy-3-methylbutyrate 0
                                      (S)-2-hydroxy-3-oxo-4-(phosphonatooxy)butanoate(3-) 0
                                      (S)-3,4-dihydroxy-2-oxobutanoate 0
                                      (S)-3-(imidazol-5-yl)lactate 0
                                      (S)-3-fluorolactate 0
                                      (S)-3-hydroxy-2-oxo-3-phenylpropanoate 0
                                      (S)-4-hydroxy-1-pyrroline-2-carboxylate 0
                                      (S,S)-9,10-dihydroxyoctadecanoate 0
                                      1,4-dihydroxy-2-naphthoate + 0
                                      1-deoxy-11beta-hydroxypentalenate 0
                                      1-hydroxy-2-naphthoate 0
                                      11-hydroxyjasmonate 0
                                      12,20-dioxoleukotriene B4(1-) 0
                                      12-hydroxyjasmonates + 0
                                      13-hydroxydocosanoate 0
                                      2,3-dihydroxy-2,3-dihydrobenzoate 0
                                      2,3-dihydroxy-2-methylpropanoate 0
                                      2,3-dihydroxy-3-methylbutanoate + 0
                                      2,3-diketogulonate 0
                                      2,4-dihydroxy-5-methyl-6-oxo-2,4-hexadienoate + 0
                                      2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate 0
                                      2-(alpha-D-mannosyl)-3-phosphonatoglycerate(3-) 0
                                      2-(beta-D-glucosyloxy)-cis-cinnamate 0
                                      2-(hydroxymethyl)-4-oxobutanoate 0
                                      2-O-(alpha-D-glucopyranosyl)-D-glycerate 0
                                      2-O-[6-O-octanoyl-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl]-D-glycerate 0
                                      2-O-[alpha-D-glucosyl-(1->6)-alpha-D-glucosyl]-D-glycerate 0
                                      2-acetyllactate 0
                                      2-carbonyl-3-prenyl-1,4-naphthoquinone + 0
                                      2-hydroxy carboxylate + 0
                                      2-hydroxy-3-methylbutyrate 0
                                      2-hydroxy-3-oxopropanoate 0
                                      2-hydroxy-6-(2-oxidophenyl)-6-oxo-cis,cis-hexa-2,4-dienoate(2-) 0
                                      2-hydroxy-6-oxo-2,4-heptadienoate + 0
                                      2-hydroxy-6-oxo-7-methylocta-2,4-dienoate 0
                                      2-hydroxy-6-oxo-nona-2,4-dienoate 0
                                      2-hydroxy-6-oxohexa-2,4-dienoate + 0
                                      2-hydroxy-6-oxoocta-2,4-dienoate 0
                                      2-hydroxyibuprofen(1-) 0
                                      2-hydroxypentanoate 0
                                      2-phosphonato-D-glycerate(3-) 0
                                      2-prenyl-1,4-naphthoquinone 0
                                      20-hydroxy-leukotriene B4(1-) 0
                                      20-oxoleukotriene B4(1-) 0
                                      3,4-dihydroxymandelate + 0
                                      3,5-dihydroxy-3-methylpentanoate + 0
                                      3-(3,4-dihydroxyphenyl)lactate + 0
                                      3-(4-hydroxyphenyl)lactate + 0
                                      3-(6-hydroxyindol-3-yl)lactate 0
                                      3-(imidazol-5-yl)lactate 0
                                      3-ADP-glycerate(3-) 0
                                      3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1,5-dioxo-octahydroinden-4-yl]propanoate 0
                                      3-[(5R,6S)-5,6-dihydroxycyclohexa-1,3-dienyl]acrylate + 0
                                      3-[(5S,6R)-5,6-dihydroxycyclohexa-1,3-dienyl]acrylate + 0
                                      3-dehydroquinate 0
                                      3-dimethylallyl-4-hydroxymandelate 0
                                      3-hydroxy-3-methyl-2-oxobutanoate 0
                                      3-hydroxy-3-methyl-2-oxopentanoate + 0
                                      3-hydroxy-3-methylhexanoate 0
                                      3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + 0
                                      3-hydroxy-5-oxohexanoate + 0
                                      3-hydroxydecanoyl-3-hydroxydecanoate + 0
                                      3-hydroxyhexanoate 0
                                      3-hydroxyisobutyrate + 0
                                      3-hydroxyisovalerate 0
                                      3-hydroxyphenylacetate 0
                                      3-hydroxypropionate 0
                                      3-hydroxypyruvate 0
                                      3-oxoisoapionate + 0
                                      3-oxoisoapionate 4-phosphate(2-) + 0
                                      3-phosphonato-D-glycerate(3-) 0
                                      3-phosphonatoshikimate(3-) 0
                                      3-sulfonatolactate(2-) + 0
                                      3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate 0
                                      3alpha-hydroxy-3,5-dihydromonacolin L carboxylate 0
                                      4-O-beta-D-glucosyl-trans-caffeate 0
                                      4-O-feruloyl-D-quinate 0
                                      4-O-phosphonato-D-erythronate(3-) 0
                                      4-O-phosphonato-D-threonate(3-) 0
                                      4-amino-3-hydroxybutanoate 0
                                      4-coumaroylshikimate 0
                                      4-hydroxy monocarboxylic acid anion + 0
                                      4-hydroxy-1-pyrroline-2-carboxylate 0
                                      4-hydroxy-2-oxopentanoate + 0
                                      4-hydroxy-all-trans-13,14-dihydroretinoate 0
                                      4a,5-dihydro-ML-236C carboxylate 0
                                      5-[(E)-caffeoyl]shikimate 0
                                      5-hydroxy-2,4-dioxopentanoate 0
                                      5-hydroxypentanoate + 0
                                      6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + 0
                                      6-hydroxyphenazine-1-carboxylate 0
                                      6-phosphonato-5-dehydro-2-deoxy-D-gluconate(3-) 0
                                      7(S),8(S)-DiHODE(1-) 0
                                      7,8-dihydro-7,8-dihydroxykynurenate 0
                                      7,8-dihydroxykynurenate 0
                                      9-cis-4-hydroxyretinoate 0
                                      9-riburonosylhypoxanthine(1-) 0
                                      D-apionate 0
                                      Delta(9)-tetrahydrocannabinolate 0
                                      L-threonate 0
                                      ML-236A carboxylate 0
                                      ML-236C carboxylate 0
                                      N-[(9-beta-D-ribofuranosylpurin-6-yl)carbamoyl]threonate 0
                                      N-acetyl-D-muramoyl-L-alaninate + 0
                                      N-adenylylanthranilate 0
                                      SN-38 carboxylate 0
                                      [(1S)-4-hydroxy-2,2,3-trimethylcyclopent-3-enyl]acetate 0
                                      all-trans-16-hydroxyretinoate 0
                                      all-trans-18-hydroxyretinoate 0
                                      all-trans-4,16-dihydroxyretinoate 0
                                      all-trans-4,18-dihydroxyretinoate 0
                                      all-trans-4-hydroxyretinoate + 0
                                      all-trans-4-oxo-16-hydroxyretinoate 0
                                      all-trans-4-oxo-18-hydroxyretinoate 0
                                      atrochrysone carboxylate 0
                                      cannabichromenate 0
                                      cerivastatin(1-) + 0
                                      cis,cis-2-hydroxy-6-oxohepta-2,4-dienoate 0
                                      cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate(2-) 0
                                      cis-4-coumarate 0
                                      cis-4-hydroxycyclohexane-1-carboxylate 0
                                      cis-5,6-dihydroxy-4-isopropylcyclohexa-1,3-dienecarboxylate 0
                                      cis-caffeate 0
                                      demethylsulochrin(1-) 0
                                      demethylsulochrin(2-) 0
                                      dihydromonacolin L carboxylate 0
                                      enol-phenylpyruvate 0
                                      erythronate + 0
                                      glycerate + 0
                                      glycolate + 0
                                      hainanate A 0
                                      hexacyclonate + 0
                                      homogentisate 0
                                      homovanillate 0
                                      hydroxy fatty acid anion + 0
                                      hydroxybenzoate + 6
                                      lactate + 2
                                      leukotriene B4(1-) 0
                                      mandelate + 0
                                      mevaldate + 0
                                      mevinic acid anion 0
                                      mevinolinate 0
                                      monacolin J carboxylate 0
                                      monacolin L carboxylate 0
                                      mutalomycin(1-) + 0
                                      o-orsellinate depsidate(1-) 0
                                      pentalenate 0
                                      phloretate 0
                                      pitavastatin(1-) + 29
                                      rifamycin B(2-) 0
                                      rosuvastatin(1-) + 49
                                      sch 210971(2-) 0
                                      sch 210972(2-) 0
                                      shikimate + 0
                                      soppiline A(1-) 0
                                      soppiline C(1-) 0
                                      sordaricin(1-) 0
                                      stipitatate(1-) 0
                                      stipitatate(2-) 0
                                      tetracenomycin D3(1-) 0
                                      tetracenomycin D3(2-) 0
                                      tetracenomycin F1(1-) 0
                                      tetracenomycin F2(1-) 0
                                      tetracenomycin F2(2-) 0
                                      trans-4-hydroxycyclohexanecarboxylate 0
                                      trans-5-O-(4-coumaroyl)-D-quinate 0
                                      trans-5-O-caffeoyl-D-quinate 0
                                      trans-beta-D-glucosyl-2-hydroxycinnamate 0
                                      trans-caffeate + 0
                                      tropate 0
                                      vanillylmandelate 0
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