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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hydroxy monocarboxylic acid anion
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Accession:CHEBI:36059 term browser browse the term
Definition:Any monocarboxylic acid anion carrying at least one hydroxy substituent.
Synonyms:related_synonym: hydroxy monocarboxylic acid anions;   hydroxymonocarboxylic acid anion;   hydroxymonocarboxylic acid anions


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3,4-dihydroxybenzoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Epas1 endothelial PAS domain protein 1 increases expression
multiple interactions
ISO 3,4-dihydroxybenzoate results in increased expression of EPAS1 mRNA
[3,4-dihydroxybenzoate co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EPAS1 mRNA
CTD PMID:19679656 NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression
affects localization
multiple interactions
ISO
EXP
3,4-dihydroxybenzoate results in increased expression of HIF1A mRNA
3,4-dihydroxybenzoate affects the localization of HIF1A protein
[3,4-dihydroxybenzoate co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine metabolite] affects the localization of HIF1A protein
[3,4-dihydroxybenzoate co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HIF1A mRNA
CTD PMID:19679656 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO [3,4-dihydroxybenzoate co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HMOX1 mRNA; [3,4-dihydroxybenzoate co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HMOX1 protein
3,4-dihydroxybenzoate results in increased expression of HMOX1 mRNA; 3,4-dihydroxybenzoate results in increased expression of HMOX1 protein
CTD PMID:19679656 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Slc40a1 solute carrier family 40 member 1 multiple interactions ISO 3,4-dihydroxybenzoate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC40A1 protein] CTD PMID:19679656 NCBI chr 9:52,819,451...52,830,461
Ensembl chr 9:52,894,365...52,912,293
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
ISO [3,4-dihydroxybenzoate co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SOD2 protein
3,4-dihydroxybenzoate results in increased expression of SOD2 protein
CTD PMID:19679656 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
physostigmine salicylate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO physostigmine salicylate results in decreased activity of ACHE protein CTD PMID:623676 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
pitavastatin(1-) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions
increases expression
EXP
ISO
GW 6471 inhibits the reaction [pitavastatin results in increased expression of ABCA1 mRNA]
pitavastatin inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in increased expression of ABCA1 protein]
GW 6471 inhibits the reaction [pitavastatin results in increased expression of ABCA1 mRNA]; PPARA protein affects the reaction [pitavastatin results in increased expression of ABCA1 mRNA]
CTD PMID:16415093, PMID:21554872 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO pitavastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]; pitavastatin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
pitavastatin results in decreased activity of ABCB11 protein
CTD PMID:15901796, PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects transport ISO ABCB1 protein affects the transport of pitavastatin CTD PMID:15955871 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
affects transport
EXP
ISO
ABCC2 protein binds to and results in increased uptake of pitavastatin analog; pitavastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]
ABCC2 protein affects the transport of pitavastatin
CTD PMID:15955871, PMID:23562342 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 affects transport ISO ABCG2 protein affects the transport of pitavastatin CTD PMID:15955871 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of CCL2 mRNA]; pitavastatin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA] CTD PMID:18323514 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO pitavastatin inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; pitavastatin inhibits the reaction [Palmitic Acid results in increased expression of IFNB1 mRNA]; pitavastatin inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA] CTD PMID:18323514 NCBI chr 5:106,865,192...106,865,746
Ensembl chr 5:106,865,192...106,865,746
JBrowse link
G Il6 interleukin 6 multiple interactions ISO pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of IL6 mRNA]; pitavastatin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; pitavastatin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; pitavastatin inhibits the reaction [Palmitic Acid results in increased expression of IL6 mRNA]; pitavastatin inhibits the reaction [Poly I-C results in increased expression of IL6 mRNA] CTD PMID:18323514 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions ISO pitavastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRF3 protein]; pitavastatin inhibits the reaction [Palmitic Acid results in increased phosphorylation of IRF3 protein] CTD PMID:18323514 NCBI chr 1:100,992,244...100,997,202
Ensembl chr 1:100,992,405...100,997,198
JBrowse link
G Lep leptin multiple interactions ISO pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of CCL2 mRNA]; pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of IL6 mRNA]; pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of TNF mRNA] CTD PMID:18323514 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO pitavastatin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; pitavastatin inhibits the reaction [Palmitic Acid results in increased expression of NOS2 mRNA]; pitavastatin inhibits the reaction [Poly I-C results in increased expression of NOS2 mRNA] CTD PMID:18323514 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 multiple interactions ISO NR1H2 gene mutant form inhibits the reaction [pitavastatin inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in increased export of Cholesterol]]; NR1H2 gene mutant form inhibits the reaction [pitavastatin results in decreased export of Cholesterol] CTD PMID:16415093 NCBI chr 1:100,554,577...100,559,896
Ensembl chr 1:100,554,544...100,559,942
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions ISO NR1H3 gene mutant form inhibits the reaction [pitavastatin inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in increased export of Cholesterol]]; NR1H3 gene mutant form inhibits the reaction [pitavastatin results in decreased export of Cholesterol] CTD PMID:16415093 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750
JBrowse link
G Pon1 paraoxonase 1 multiple interactions
increases expression
ISO farnesyl pyrophosphate inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA]; Mevalonic Acid inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA]; Plicamycin inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA] CTD PMID:15690306 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases expression
ISO pitavastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]; PPARA protein affects the reaction [pitavastatin results in increased expression of ABCA1 mRNA]
pitavastatin results in increased expression of PPARA mRNA
CTD PMID:11779144, PMID:21554872 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases expression ISO pitavastatin results in increased expression of PPARD mRNA CTD PMID:21554872 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO pitavastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]] CTD PMID:11779144 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects transport ISO SLCO1A4 protein affects the transport of pitavastatin CTD PMID:19833843 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO pitavastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein] CTD PMID:18323514 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of TNF mRNA]; pitavastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:18323514 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
rosuvastatin calcium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 decreases expression
multiple interactions
ISO Rosuvastatin Calcium results in decreased expression of ABCA1 mRNA
Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of ABCA1 mRNA]
CTD PMID:18192897 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO
EXP
Rosuvastatin Calcium inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]
[Cyclosporine results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium; [Glyburide results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium; [troglitazone results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium
CTD PMID:15901796, PMID:19853032 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
increases expression
affects secretion
ISO
EXP
ABCC2 protein binds to and results in increased uptake of Rosuvastatin Calcium analog; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]
Rosuvastatin Calcium results in increased expression of ABCC2 protein
[Benzbromarone results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; [Probenecid results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; [Sulfasalazine results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; ABCC2 protein binds to and results in increased uptake of Rosuvastatin Calcium analog; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Rosuvastatin Calcium promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]
ABCC2 protein affects the secretion of Rosuvastatin Calcium
CTD PMID:19853032, PMID:23562342, PMID:24909372 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Rosuvastatin Calcium results in increased expression of ABCC3 protein CTD PMID:24909372 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 decreases expression ISO Rosuvastatin Calcium results in decreased expression of ABCG1 mRNA CTD PMID:18192897 NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases activity
EXP
ISO
[Novobiocin results in decreased activity of ABCG2 protein] which results in decreased secretion of Rosuvastatin Calcium
Rosuvastatin Calcium results in increased activity of ABCG2 protein
CTD PMID:19853032, PMID:30083819 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects phosphorylation EXP Rosuvastatin Calcium affects the phosphorylation of AKT1 protein CTD PMID:27815113 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions
increases expression
ISO Niacin promotes the reaction [Rosuvastatin Calcium results in increased expression of APOA1 protein] CTD PMID:12767421, PMID:15539964 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Apob apolipoprotein B decreases expression ISO Rosuvastatin Calcium results in decreased expression of APOB protein CTD PMID:15539964, PMID:18702965 NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of BAX mRNA] CTD PMID:32007421 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Rosuvastatin Calcium results in decreased expression of BCL2 protein CTD PMID:20852871 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases activity ISO Rosuvastatin Calcium results in increased activity of CASP3 protein CTD PMID:21478229 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase increases activity
multiple interactions
EXP Rosuvastatin Calcium results in increased activity of CAT protein
[Rosuvastatin Calcium co-treated with Isoproterenol] inhibits the reaction [Interleukin-6 results in increased expression of CAT protein]; Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]
CTD PMID:20146376, PMID:32007421 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression EXP Rosuvastatin Calcium results in decreased expression of CCL2 mRNA CTD PMID:15681303 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Creb5 cAMP responsive element binding protein 5 decreases expression ISO Rosuvastatin Calcium results in decreased expression of CREB5 mRNA CTD PMID:18192897 NCBI chr 4:83,390,782...83,840,356
Ensembl chr 4:83,391,283...83,836,351
JBrowse link
G Crp C-reactive protein multiple interactions ISO Rosuvastatin Calcium inhibits the reaction [CRP protein results in decreased expression of NOS3] CTD PMID:21562509 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions
decreases expression
EXP [[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species CTD PMID:21562509 NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions
decreases expression
ISO
EXP
Rosuvastatin Calcium inhibits the reaction [Nitroglycerin results in increased expression of CYBB mRNA]
[[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species
CTD PMID:16633368, PMID:21562509 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO Rosuvastatin Calcium results in increased expression of GCLC mRNA
[Tetradecanoylphorbol Acetate co-treated with Rosuvastatin Calcium] results in increased expression of GCLC mRNA
CTD PMID:18154958 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gpr183 G protein-coupled receptor 183 multiple interactions
increases expression
ISO Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in increased expression of GPR183 mRNA] CTD PMID:18192897 NCBI chr15:108,364,701...108,376,221
Ensembl chr15:108,364,701...108,376,221
JBrowse link
G Gzmk granzyme K multiple interactions
increases expression
ISO Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in increased expression of GZMK mRNA] CTD PMID:18192897 NCBI chr 2:45,069,136...45,077,154
Ensembl chr 2:45,068,967...45,077,219
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha increases secretion ISO HNF4A protein results in increased secretion of Rosuvastatin Calcium CTD PMID:27160211 NCBI chr 3:159,902,441...159,965,003
Ensembl chr 3:159,902,441...159,965,003
JBrowse link
G Il18rap interleukin 18 receptor accessory protein decreases expression
multiple interactions
ISO Rosuvastatin Calcium results in decreased expression of IL18RAP mRNA
Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of IL18RAP mRNA]
CTD PMID:18192897 NCBI chr 9:47,225,543...47,255,805
Ensembl chr 9:47,225,585...47,258,503
JBrowse link
G Il1b interleukin 1 beta decreases expression EXP Rosuvastatin Calcium results in decreased expression of IL1B mRNA CTD PMID:15681303 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Rosuvastatin Calcium results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kcnj15 potassium inwardly-rectifying channel, subfamily J, member 15 decreases expression ISO Rosuvastatin Calcium results in decreased expression of KCNJ15 mRNA CTD PMID:18192897 NCBI chr11:35,545,185...35,588,517
Ensembl chr11:35,568,182...35,585,390
JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of KDR protein] CTD PMID:27097221 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Mb myoglobin affects expression EXP Rosuvastatin Calcium affects the expression of MB protein CTD PMID:27815113 NCBI chr 7:118,101,633...118,108,864
Ensembl chr 7:118,101,634...118,108,864
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in decreased expression of NFE2L2 mRNA] CTD PMID:32007421 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
EXP Rosuvastatin Calcium results in increased expression of NOS2 mRNA
Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of NOS2 mRNA]
CTD PMID:21443142, PMID:32007421 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
increases expression
affects response to substance
ISO
EXP
Rosuvastatin Calcium inhibits the reaction [CRP protein results in decreased expression of NOS3]; Rosuvastatin Calcium results in increased phosphorylation of and results in increased activity of NOS3 protein
Rosuvastatin Calcium results in increased expression of NOS3 mRNA
NOS3 protein affects the susceptibility to Rosuvastatin Calcium
CTD PMID:12354446, PMID:15681303, PMID:18162361, PMID:21562509 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Orm1 orosomucoid 1 multiple interactions
decreases expression
ISO Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of ORM1 mRNA] CTD PMID:18192897 NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 multiple interactions ISO Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of PECAM1 protein] CTD PMID:27097221 NCBI chr10:94,850,971...94,913,202 JBrowse link
G Selp selectin P decreases expression EXP Rosuvastatin Calcium results in decreased expression of SELP mRNA CTD PMID:15681303 NCBI chr13:82,428,914...82,464,629
Ensembl chr13:82,429,063...82,464,628
JBrowse link
G Serpine2 serpin family E member 2 multiple interactions ISO Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SERPINE2 protein]; Rosuvastatin Calcium inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein] CTD PMID:27097221 NCBI chr 9:85,560,852...85,629,410
Ensembl chr 9:85,560,863...85,626,094
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions
increases uptake
decreases expression
affects transport
EXP
ISO
Fusidic Acid inhibits the reaction [SLCO1A4 protein results in increased uptake of Rosuvastatin Calcium]
diosmetin inhibits the reaction [SLCO1A2 protein results in increased uptake of Rosuvastatin Calcium]
Rosuvastatin Calcium results in decreased expression of SLCO1A4 protein
SLCO1A4 protein affects the transport of Rosuvastatin Calcium
CTD PMID:19833843, PMID:24909372, PMID:26888941, PMID:28867436 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions
increases uptake
EXP
ISO
Fusidic Acid inhibits the reaction [SLCO1B2 protein results in increased uptake of Rosuvastatin Calcium]
Fusidic Acid inhibits the reaction [SLCO1B3 protein results in increased uptake of Rosuvastatin Calcium]
CTD PMID:26888941, PMID:31299240 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions
increases uptake
ISO Rutin promotes the reaction [SLCO2B1 protein results in increased uptake of Rosuvastatin Calcium] CTD PMID:24285294 NCBI chr 1:164,623,313...164,671,612
Ensembl chr 1:164,623,599...164,671,577
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression
EXP [[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species CTD PMID:21562509 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression
ISO
EXP
Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TGFB1 protein]; Rosuvastatin Calcium inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]
Rosuvastatin Calcium results in decreased expression of TGFB1 mRNA
CTD PMID:15681303, PMID:27097221 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
EXP Rosuvastatin Calcium results in decreased expression of TNF mRNA
Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of TNF protein]
CTD PMID:15681303, PMID:32007421 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions EXP Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of TNNI3 protein] CTD PMID:32007421 NCBI chr 1:72,882,806...72,886,490
Ensembl chr 1:72,882,806...72,886,488
JBrowse link
G Vnn3 vanin 3 decreases expression ISO Rosuvastatin Calcium results in decreased expression of VNN3 mRNA CTD PMID:18192897 NCBI chr 1:22,649,114...22,661,376
Ensembl chr 1:22,649,081...22,661,377
JBrowse link
G Wt1 WT1 transcription factor increases expression EXP Rosuvastatin Calcium results in increased expression of WT1 mRNA CTD PMID:21443142 NCBI chr 3:95,133,221...95,180,574
Ensembl chr 3:95,133,713...95,180,564
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    chemical entity 19791
      molecular entity 19787
        ion 15930
          anion 14935
            organic anion 3008
              carboxylic acid anion 2390
                monocarboxylic acid anion 1487
                  hydroxy monocarboxylic acid anion 62
                    (+)-8'-hydroxyabscisate 0
                    (-)-ureidoglycolate 0
                    (1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate 0
                    (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate 0
                    (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate 0
                    (2,6-dihydroxyphenyl)acetate 0
                    (2E,4E)-3,8,8,8-tetrachloro-7-(4-chlorophenyl)-2-hydroxy-6-oxo-octa-2,4-dienoate 0
                    (2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate 0
                    (2E,4Z)-2-hydroxy-6-oxoocta-2,4,7-trienoate 0
                    (2E,4Z)-2-hydroxy-7-methyl-6-oxo-2,4-octadienoate 0
                    (2R)-2-hydroxy monocarboxylic acid anion + 0
                    (2R)-2-hydroxy-4-(methylsulfanyl)butanoate 0
                    (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate 0
                    (2R,3R)-2,3-dihydroxy-3-methylpentanoate 0
                    (2R,3S)-2-alkyl-3-hydroxyalkanoate 0
                    (2S)-2-hydroxy monocarboxylic acid anion + 0
                    (2S)-2-hydroxy-2-methyl-3-oxobutanoate 0
                    (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate 0
                    (2Z,4Z)-3,8,8-trichloro-7-(4-chlorophenyl)-2-hydroxy-6-oxoocta-2,4,7-trienoate 0
                    (3,4-dihydroxyphenyl)acetate 0
                    (3R)-3-\{[(3R)-3-\{[(3R)-3-\{[(3R)-3-\{[(3R)-3-hydroxybutanoyl]oxy\}butanoyl]oxy\}butanoyl]oxy\}butanoyl]oxy\}butanoate 0
                    (3R)-3-\{[(3R)-3-\{[(3R)-3-\{[(3R)-3-hydroxybutanoyl]oxy\}butanoyl]oxy\}butanoyl]oxy\}butanoate 0
                    (3R)-3-\{[(3R)-3-\{[(3R)-3-hydroxybutanoyl]oxy\}butanoyl]oxy\}butanoate 0
                    (3R,4R)-3,4-dihydroxycyclohexa-1,5-diene-1-carboxylate 0
                    (4E,6E)-3-hydroxydeca-4,6-dienoate 0
                    (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate 0
                    (5Z,9E,12S,14Z)-8,11,12-trihydroxyicosa-5,9,14-trienoate 0
                    (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate 0
                    (9S,10R)-10-hydroxy-9-(phosphonatooxy)octadecanoate 0
                    (9S,10S)-10-hydroxy-9-(phosphonatooxy)octadecanoate 0
                    (R)-10-hydroxyoctadecanoate 0
                    (R)-2,4-dihydroxy-3-oxobutanoate 0
                    (R)-2-hydroxy-3-methylbutyrate 0
                    (R)-2-hydroxy-3-oxo-4-(phosphonatooxy)butanoate(3-) 0
                    (R)-2-hydroxy-4-(hydroxymethylphosphinyl)butyrate 0
                    (R)-2-hydroxy-4-methylpentanoate 0
                    (R)-2-hydroxynonanoate 0
                    (R)-3,4-dihydroxy-2-oxobutanoate 0
                    (R)-3-(5-benzyloxyindol-3-yl)lactate 0
                    (R)-3-[(R)-3-hydroxybutanoyloxy]butanoate 0
                    (R)-3-phosphonatomevalonate(3-) 0
                    (R)-4-dehydropantoate 0
                    (R)-4-phosphonatopantoate(3-) 0
                    (R)-5-phosphonatomevalonate(3-) 0
                    (R)-indole-3-lactate 0
                    (R)-pantoate 0
                    (S)-2,4-dihydroxy-3-oxobutanoate 0
                    (S)-2-acetyl-2-hydroxybutanoate 0
                    (S)-2-hydroxy-3-methylbutyrate 0
                    (S)-2-hydroxy-3-oxo-4-(phosphonatooxy)butanoate(3-) 0
                    (S)-3,4-dihydroxy-2-oxobutanoate 0
                    (S)-3-(imidazol-5-yl)lactate 0
                    (S)-3-fluorolactate 0
                    (S)-3-hydroxy-2-oxo-3-phenylpropanoate 0
                    (S)-4-hydroxy-1-pyrroline-2-carboxylate 0
                    (S,S)-9,10-dihydroxyoctadecanoate 0
                    1,4-dihydroxy-2-naphthoate 0
                    1-deoxy-11beta-hydroxypentalenate 0
                    1-hydroxy-2-naphthoate 0
                    11-hydroxyjasmonate 0
                    12,20-dioxoleukotriene B4(1-) 0
                    12-hydroxyjasmonates + 0
                    13-hydroxydocosanoate 0
                    2,3-dihydroxy-2,3-dihydrobenzoate 0
                    2,3-dihydroxy-2-methylpropanoate 0
                    2,3-dihydroxy-3-methylbutanoate + 0
                    2,3-diketogulonate 0
                    2,4-dihydroxy-5-methyl-6-oxo-2,4-hexadienoate 0
                    2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate 0
                    2-(alpha-D-mannosyl)-3-phosphonatoglycerate(3-) 0
                    2-(beta-D-glucosyloxy)-cis-cinnamate 0
                    2-(hydroxymethyl)-4-oxobutanoate 0
                    2-O-(alpha-D-glucopyranosyl)-D-glycerate 0
                    2-O-[6-O-octanoyl-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl]-D-glycerate 0
                    2-O-[alpha-D-glucosyl-(1->6)-alpha-D-glucosyl]-D-glycerate 0
                    2-acetyllactate 0
                    2-hydroxy carboxylate + 0
                    2-hydroxy-3-methylbutyrate 0
                    2-hydroxy-3-oxopropanoate 0
                    2-hydroxy-6-(2-oxidophenyl)-6-oxo-cis,cis-hexa-2,4-dienoate(2-) 0
                    2-hydroxy-6-oxo-2,4-heptadienoate + 0
                    2-hydroxy-6-oxo-7-methylocta-2,4-dienoate 0
                    2-hydroxy-6-oxo-nona-2,4-dienoate 0
                    2-hydroxy-6-oxohexa-2,4-dienoate + 0
                    2-hydroxy-6-oxoocta-2,4-dienoate 0
                    2-hydroxyibuprofen(1-) 0
                    2-hydroxypentanoate 0
                    2-phosphonato-D-glycerate(3-) 0
                    20-hydroxy-leukotriene B4(1-) 0
                    20-oxoleukotriene B4(1-) 0
                    3,4-dihydroxymandelate 0
                    3-(3,4-dihydroxyphenyl)lactate + 0
                    3-(4-hydroxyphenyl)lactate + 0
                    3-(6-hydroxyindol-3-yl)lactate 0
                    3-(imidazol-5-yl)lactate 0
                    3-ADP-glycerate(3-) 0
                    3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1,5-dioxo-octahydroinden-4-yl]propanoate 0
                    3-[(5R,6S)-5,6-dihydroxycyclohexa-1,3-dienyl]acrylate + 0
                    3-[(5S,6R)-5,6-dihydroxycyclohexa-1,3-dienyl]acrylate + 0
                    3-dehydroquinate 0
                    3-dimethylallyl-4-hydroxymandelate 0
                    3-hydroxy-3-methyl-2-oxobutanoate 0
                    3-hydroxy-3-methyl-2-oxopentanoate + 0
                    3-hydroxy-3-methylhexanoate 0
                    3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + 0
                    3-hydroxy-5-oxohexanoate 0
                    3-hydroxydecanoyl-3-hydroxydecanoate + 0
                    3-hydroxyhexanoate 0
                    3-hydroxyisobutyrate + 0
                    3-hydroxyisovalerate 0
                    3-hydroxyphenylacetate 0
                    3-hydroxypropionate 0
                    3-hydroxypyruvate 0
                    3-oxoisoapionate + 0
                    3-oxoisoapionate 4-phosphate(2-) + 0
                    3-phosphonato-D-glycerate(3-) 0
                    3-phosphonatoshikimate(3-) 0
                    3-sulfonatolactate(2-) + 0
                    3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate 0
                    3alpha-hydroxy-3,5-dihydromonacolin L carboxylate 0
                    4-O-beta-D-glucosyl-trans-caffeate 0
                    4-O-feruloyl-D-quinate 0
                    4-O-phosphonato-D-erythronate(3-) 0
                    4-O-phosphonato-D-threonate(3-) 0
                    4-amino-3-hydroxybutanoate 0
                    4-coumaroylshikimate 0
                    4-hydroxy monocarboxylic acid anion + 0
                    4-hydroxy-1-pyrroline-2-carboxylate 0
                    4-hydroxy-2-oxopentanoate + 0
                    4a,5-dihydro-ML-236C carboxylate 0
                    5-[(E)-caffeoyl]shikimate 0
                    5-hydroxy-2,4-dioxopentanoate 0
                    5-hydroxypentanoate + 0
                    6-phosphonato-5-dehydro-2-deoxy-D-gluconate(3-) 0
                    7(S),8(S)-DiHODE(1-) 0
                    7,8-dihydro-7,8-dihydroxykynurenate 0
                    7,8-dihydroxykynurenate 0
                    9-cis-4-hydroxyretinoate 0
                    9-riburonosylhypoxanthine(1-) 0
                    D-apionate 0
                    Delta(9)-tetrahydrocannabinolate 0
                    L-threonate 0
                    ML-236A carboxylate 0
                    ML-236C carboxylate 0
                    N-[(9-beta-D-ribofuranosylpurin-6-yl)carbamoyl]threonate 0
                    N-acetyl-D-muramoyl-L-alaninate + 0
                    N-adenylylanthranilate 0
                    SN-38 carboxylate 0
                    [(1S)-4-hydroxy-2,2,3-trimethylcyclopent-3-enyl]acetate 0
                    all-trans-16-hydroxyretinoate 0
                    all-trans-18-hydroxyretinoate 0
                    all-trans-4,16-dihydroxyretinoate 0
                    all-trans-4,18-dihydroxyretinoate 0
                    all-trans-4-hydroxyretinoate + 0
                    all-trans-4-oxo-16-hydroxyretinoate 0
                    all-trans-4-oxo-18-hydroxyretinoate 0
                    atrochrysone carboxylate 0
                    cerivastatin(1-) + 0
                    cis,cis-2-hydroxy-6-oxohepta-2,4-dienoate 0
                    cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate(2-) 0
                    cis-4-coumarate 0
                    cis-5,6-dihydroxy-4-isopropylcyclohexa-1,3-dienecarboxylate 0
                    cis-caffeate 0
                    demethylsulochrin(1-) 0
                    demethylsulochrin(2-) 0
                    dihydromonacolin L carboxylate 0
                    enol-phenylpyruvate 0
                    erythronate + 0
                    glycerate + 0
                    glycolate + 0
                    homogentisate 0
                    homovanillate 0
                    hydroxy fatty acid anion + 0
                    hydroxybenzoate + 6
                    lactate + 0
                    leukotriene B4(1-) 0
                    mandelate + 0
                    mevaldate 0
                    mevalonate + 0
                    mevinic acid anion 0
                    mevinolinate 0
                    monacolin J carboxylate 0
                    monacolin L carboxylate 0
                    mutalomycin(1-) + 0
                    o-orsellinate depsidate(1-) 0
                    pentalenate 0
                    phloretate 0
                    pitavastatin(1-) + 20
                    rifamycin B(2-) 0
                    rosuvastatin(1-) + 44
                    shikimate + 0
                    sordaricin(1-) 0
                    stipitatate(1-) 0
                    stipitatate(2-) 0
                    tetracenomycin D3(1-) 0
                    tetracenomycin D3(2-) 0
                    tetracenomycin F1(1-) 0
                    tetracenomycin F2(1-) 0
                    tetracenomycin F2(2-) 0
                    trans-4-hydroxycyclohexanecarboxylate 0
                    trans-5-O-(4-coumaroyl)-D-quinate 0
                    trans-5-O-caffeoyl-D-quinate 0
                    trans-beta-D-glucosyl-2-hydroxycinnamate 0
                    trans-caffeate + 0
                    tropate 0
                    vanillylmandelate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19792
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19571
                        carbon atom 19560
                          organic molecular entity 19560
                            organic ion 8325
                              organic anion 3008
                                carboxylic acid anion 2390
                                  monocarboxylic acid anion 1487
                                    hydroxy monocarboxylic acid anion 62
                                      (+)-8'-hydroxyabscisate 0
                                      (-)-ureidoglycolate 0
                                      (1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate 0
                                      (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate 0
                                      (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate 0
                                      (2,6-dihydroxyphenyl)acetate 0
                                      (2E,4E)-3,8,8,8-tetrachloro-7-(4-chlorophenyl)-2-hydroxy-6-oxo-octa-2,4-dienoate 0
                                      (2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate 0
                                      (2E,4Z)-2-hydroxy-6-oxoocta-2,4,7-trienoate 0
                                      (2E,4Z)-2-hydroxy-7-methyl-6-oxo-2,4-octadienoate 0
                                      (2R)-2-hydroxy monocarboxylic acid anion + 0
                                      (2R)-2-hydroxy-4-(methylsulfanyl)butanoate 0
                                      (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate 0
                                      (2R,3R)-2,3-dihydroxy-3-methylpentanoate 0
                                      (2R,3S)-2-alkyl-3-hydroxyalkanoate 0
                                      (2S)-2-hydroxy monocarboxylic acid anion + 0
                                      (2S)-2-hydroxy-2-methyl-3-oxobutanoate 0
                                      (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate 0
                                      (2Z,4Z)-3,8,8-trichloro-7-(4-chlorophenyl)-2-hydroxy-6-oxoocta-2,4,7-trienoate 0
                                      (3,4-dihydroxyphenyl)acetate 0
                                      (3R)-3-\{[(3R)-3-\{[(3R)-3-\{[(3R)-3-\{[(3R)-3-hydroxybutanoyl]oxy\}butanoyl]oxy\}butanoyl]oxy\}butanoyl]oxy\}butanoate 0
                                      (3R)-3-\{[(3R)-3-\{[(3R)-3-\{[(3R)-3-hydroxybutanoyl]oxy\}butanoyl]oxy\}butanoyl]oxy\}butanoate 0
                                      (3R)-3-\{[(3R)-3-\{[(3R)-3-hydroxybutanoyl]oxy\}butanoyl]oxy\}butanoate 0
                                      (3R,4R)-3,4-dihydroxycyclohexa-1,5-diene-1-carboxylate 0
                                      (4E,6E)-3-hydroxydeca-4,6-dienoate 0
                                      (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate 0
                                      (5Z,9E,12S,14Z)-8,11,12-trihydroxyicosa-5,9,14-trienoate 0
                                      (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate 0
                                      (9S,10R)-10-hydroxy-9-(phosphonatooxy)octadecanoate 0
                                      (9S,10S)-10-hydroxy-9-(phosphonatooxy)octadecanoate 0
                                      (R)-10-hydroxyoctadecanoate 0
                                      (R)-2,4-dihydroxy-3-oxobutanoate 0
                                      (R)-2-hydroxy-3-methylbutyrate 0
                                      (R)-2-hydroxy-3-oxo-4-(phosphonatooxy)butanoate(3-) 0
                                      (R)-2-hydroxy-4-(hydroxymethylphosphinyl)butyrate 0
                                      (R)-2-hydroxy-4-methylpentanoate 0
                                      (R)-2-hydroxynonanoate 0
                                      (R)-3,4-dihydroxy-2-oxobutanoate 0
                                      (R)-3-(5-benzyloxyindol-3-yl)lactate 0
                                      (R)-3-[(R)-3-hydroxybutanoyloxy]butanoate 0
                                      (R)-3-phosphonatomevalonate(3-) 0
                                      (R)-4-dehydropantoate 0
                                      (R)-4-phosphonatopantoate(3-) 0
                                      (R)-5-phosphonatomevalonate(3-) 0
                                      (R)-indole-3-lactate 0
                                      (R)-pantoate 0
                                      (S)-2,4-dihydroxy-3-oxobutanoate 0
                                      (S)-2-acetyl-2-hydroxybutanoate 0
                                      (S)-2-hydroxy-3-methylbutyrate 0
                                      (S)-2-hydroxy-3-oxo-4-(phosphonatooxy)butanoate(3-) 0
                                      (S)-3,4-dihydroxy-2-oxobutanoate 0
                                      (S)-3-(imidazol-5-yl)lactate 0
                                      (S)-3-fluorolactate 0
                                      (S)-3-hydroxy-2-oxo-3-phenylpropanoate 0
                                      (S)-4-hydroxy-1-pyrroline-2-carboxylate 0
                                      (S,S)-9,10-dihydroxyoctadecanoate 0
                                      1,4-dihydroxy-2-naphthoate 0
                                      1-deoxy-11beta-hydroxypentalenate 0
                                      1-hydroxy-2-naphthoate 0
                                      11-hydroxyjasmonate 0
                                      12,20-dioxoleukotriene B4(1-) 0
                                      12-hydroxyjasmonates + 0
                                      13-hydroxydocosanoate 0
                                      2,3-dihydroxy-2,3-dihydrobenzoate 0
                                      2,3-dihydroxy-2-methylpropanoate 0
                                      2,3-dihydroxy-3-methylbutanoate + 0
                                      2,3-diketogulonate 0
                                      2,4-dihydroxy-5-methyl-6-oxo-2,4-hexadienoate 0
                                      2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate 0
                                      2-(alpha-D-mannosyl)-3-phosphonatoglycerate(3-) 0
                                      2-(beta-D-glucosyloxy)-cis-cinnamate 0
                                      2-(hydroxymethyl)-4-oxobutanoate 0
                                      2-O-(alpha-D-glucopyranosyl)-D-glycerate 0
                                      2-O-[6-O-octanoyl-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl]-D-glycerate 0
                                      2-O-[alpha-D-glucosyl-(1->6)-alpha-D-glucosyl]-D-glycerate 0
                                      2-acetyllactate 0
                                      2-hydroxy carboxylate + 0
                                      2-hydroxy-3-methylbutyrate 0
                                      2-hydroxy-3-oxopropanoate 0
                                      2-hydroxy-6-(2-oxidophenyl)-6-oxo-cis,cis-hexa-2,4-dienoate(2-) 0
                                      2-hydroxy-6-oxo-2,4-heptadienoate + 0
                                      2-hydroxy-6-oxo-7-methylocta-2,4-dienoate 0
                                      2-hydroxy-6-oxo-nona-2,4-dienoate 0
                                      2-hydroxy-6-oxohexa-2,4-dienoate + 0
                                      2-hydroxy-6-oxoocta-2,4-dienoate 0
                                      2-hydroxyibuprofen(1-) 0
                                      2-hydroxypentanoate 0
                                      2-phosphonato-D-glycerate(3-) 0
                                      20-hydroxy-leukotriene B4(1-) 0
                                      20-oxoleukotriene B4(1-) 0
                                      3,4-dihydroxymandelate 0
                                      3-(3,4-dihydroxyphenyl)lactate + 0
                                      3-(4-hydroxyphenyl)lactate + 0
                                      3-(6-hydroxyindol-3-yl)lactate 0
                                      3-(imidazol-5-yl)lactate 0
                                      3-ADP-glycerate(3-) 0
                                      3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1,5-dioxo-octahydroinden-4-yl]propanoate 0
                                      3-[(5R,6S)-5,6-dihydroxycyclohexa-1,3-dienyl]acrylate + 0
                                      3-[(5S,6R)-5,6-dihydroxycyclohexa-1,3-dienyl]acrylate + 0
                                      3-dehydroquinate 0
                                      3-dimethylallyl-4-hydroxymandelate 0
                                      3-hydroxy-3-methyl-2-oxobutanoate 0
                                      3-hydroxy-3-methyl-2-oxopentanoate + 0
                                      3-hydroxy-3-methylhexanoate 0
                                      3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + 0
                                      3-hydroxy-5-oxohexanoate 0
                                      3-hydroxydecanoyl-3-hydroxydecanoate + 0
                                      3-hydroxyhexanoate 0
                                      3-hydroxyisobutyrate + 0
                                      3-hydroxyisovalerate 0
                                      3-hydroxyphenylacetate 0
                                      3-hydroxypropionate 0
                                      3-hydroxypyruvate 0
                                      3-oxoisoapionate + 0
                                      3-oxoisoapionate 4-phosphate(2-) + 0
                                      3-phosphonato-D-glycerate(3-) 0
                                      3-phosphonatoshikimate(3-) 0
                                      3-sulfonatolactate(2-) + 0
                                      3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate 0
                                      3alpha-hydroxy-3,5-dihydromonacolin L carboxylate 0
                                      4-O-beta-D-glucosyl-trans-caffeate 0
                                      4-O-feruloyl-D-quinate 0
                                      4-O-phosphonato-D-erythronate(3-) 0
                                      4-O-phosphonato-D-threonate(3-) 0
                                      4-amino-3-hydroxybutanoate 0
                                      4-coumaroylshikimate 0
                                      4-hydroxy monocarboxylic acid anion + 0
                                      4-hydroxy-1-pyrroline-2-carboxylate 0
                                      4-hydroxy-2-oxopentanoate + 0
                                      4a,5-dihydro-ML-236C carboxylate 0
                                      5-[(E)-caffeoyl]shikimate 0
                                      5-hydroxy-2,4-dioxopentanoate 0
                                      5-hydroxypentanoate + 0
                                      6-phosphonato-5-dehydro-2-deoxy-D-gluconate(3-) 0
                                      7(S),8(S)-DiHODE(1-) 0
                                      7,8-dihydro-7,8-dihydroxykynurenate 0
                                      7,8-dihydroxykynurenate 0
                                      9-cis-4-hydroxyretinoate 0
                                      9-riburonosylhypoxanthine(1-) 0
                                      D-apionate 0
                                      Delta(9)-tetrahydrocannabinolate 0
                                      L-threonate 0
                                      ML-236A carboxylate 0
                                      ML-236C carboxylate 0
                                      N-[(9-beta-D-ribofuranosylpurin-6-yl)carbamoyl]threonate 0
                                      N-acetyl-D-muramoyl-L-alaninate + 0
                                      N-adenylylanthranilate 0
                                      SN-38 carboxylate 0
                                      [(1S)-4-hydroxy-2,2,3-trimethylcyclopent-3-enyl]acetate 0
                                      all-trans-16-hydroxyretinoate 0
                                      all-trans-18-hydroxyretinoate 0
                                      all-trans-4,16-dihydroxyretinoate 0
                                      all-trans-4,18-dihydroxyretinoate 0
                                      all-trans-4-hydroxyretinoate + 0
                                      all-trans-4-oxo-16-hydroxyretinoate 0
                                      all-trans-4-oxo-18-hydroxyretinoate 0
                                      atrochrysone carboxylate 0
                                      cerivastatin(1-) + 0
                                      cis,cis-2-hydroxy-6-oxohepta-2,4-dienoate 0
                                      cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate(2-) 0
                                      cis-4-coumarate 0
                                      cis-5,6-dihydroxy-4-isopropylcyclohexa-1,3-dienecarboxylate 0
                                      cis-caffeate 0
                                      demethylsulochrin(1-) 0
                                      demethylsulochrin(2-) 0
                                      dihydromonacolin L carboxylate 0
                                      enol-phenylpyruvate 0
                                      erythronate + 0
                                      glycerate + 0
                                      glycolate + 0
                                      homogentisate 0
                                      homovanillate 0
                                      hydroxy fatty acid anion + 0
                                      hydroxybenzoate + 6
                                      lactate + 0
                                      leukotriene B4(1-) 0
                                      mandelate + 0
                                      mevaldate 0
                                      mevalonate + 0
                                      mevinic acid anion 0
                                      mevinolinate 0
                                      monacolin J carboxylate 0
                                      monacolin L carboxylate 0
                                      mutalomycin(1-) + 0
                                      o-orsellinate depsidate(1-) 0
                                      pentalenate 0
                                      phloretate 0
                                      pitavastatin(1-) + 20
                                      rifamycin B(2-) 0
                                      rosuvastatin(1-) + 44
                                      shikimate + 0
                                      sordaricin(1-) 0
                                      stipitatate(1-) 0
                                      stipitatate(2-) 0
                                      tetracenomycin D3(1-) 0
                                      tetracenomycin D3(2-) 0
                                      tetracenomycin F1(1-) 0
                                      tetracenomycin F2(1-) 0
                                      tetracenomycin F2(2-) 0
                                      trans-4-hydroxycyclohexanecarboxylate 0
                                      trans-5-O-(4-coumaroyl)-D-quinate 0
                                      trans-5-O-caffeoyl-D-quinate 0
                                      trans-beta-D-glucosyl-2-hydroxycinnamate 0
                                      trans-caffeate + 0
                                      tropate 0
                                      vanillylmandelate 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.