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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:omega-6 fatty acid
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Accession:CHEBI:36009 term browser browse the term
Definition:A family of polyunsaturated fatty acids that have in common a final carbon-carbon double bond in the n-6 position, i.e., the sixth bond from the methyl end of the fatty acid.
Synonyms:related_synonym: omega-6 fatty acids
 alt_id: MESH:D043371
 xref_mesh: MESH:D043371
 xref: PMID:19035453;   PMID:19136835


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linoleic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA5 annexin A5 multiple interactions
increases activity
EXP Linoleic Acid promotes the reaction [TNF protein results in increased activity of ANXA5 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of ANXA5 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of ANXA5 protein]]; TNF protein promotes the reaction [Linoleic Acid results in increased activity of ANXA5 protein]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of ANXA5 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of ANXA5 protein]]] CTD PMID:10617950 NCBI chr 8:102,387,833...102,420,868
Ensembl chr 8:102,388,103...102,425,750
JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity
EXP Linoleic Acid promotes the reaction [TNF protein results in increased activity of CASP3 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of CASP3 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]; TNF protein promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]; Zinc Acetate inhibits the reaction [Linoleic Acid results in increased activity of CASP3 protein]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of CASP3 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]; Zinc Acetate promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]] CTD PMID:10617950 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G IL6 interleukin 6 increases expression
multiple interactions
EXP Linoleic Acid results in increased expression of IL6 mRNA; Linoleic Acid results in increased expression of IL6 protein
2,4-thiazolidinedione inhibits the reaction [Linoleic Acid results in increased expression of IL6 protein]; PPARG protein promotes the reaction [Linoleic Acid results in increased expression of IL6 protein]; Quercetin inhibits the reaction [Linoleic Acid results in increased expression of IL6 mRNA]
CTD PMID:14519784, PMID:15051824 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions
increases activity
EXP PPARG protein promotes the reaction [Linoleic Acid results in increased activity of RELA protein]; PPARG protein promotes the reaction [Linoleic Acid results in increased expression of IL6 protein]; Quercetin inhibits the reaction [Linoleic Acid results in increased activity of PPARG protein]; Vitamin E inhibits the reaction [Linoleic Acid results in increased activity of PPARG protein] CTD PMID:14519784, PMID:15051824 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,655...68,433,947
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
EXP Linoleic Acid results in increased expression of PTGS2 mRNA
Linoleic Acid promotes the reaction [[Polychlorinated Biphenyls results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Linoleic Acid promotes the reaction [Polychlorinated Biphenyls results in increased expression of PTGS2 mRNA]; Linoleic Acid promotes the reaction [Polychlorinated Biphenyls results in increased expression of PTGS2 protein]; Polychlorinated Biphenyls promotes the reaction [[Linoleic Acid results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; prolinedithiocarbamate inhibits the reaction [[Linoleic Acid co-treated with Polychlorinated Biphenyls] results in increased expression of PTGS2 mRNA]; prolinedithiocarbamate inhibits the reaction [Linoleic Acid results in increased expression of PTGS2 mRNA]
CTD PMID:18155686 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,013...127,858,884
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions
increases activity
EXP 2,4-thiazolidinedione inhibits the reaction [Linoleic Acid results in increased activity of RELA protein]; PPARG protein promotes the reaction [Linoleic Acid results in increased activity of RELA protein] CTD PMID:14519784 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,471
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP Linoleic Acid promotes the reaction [TNF protein results in increased activity of ANXA5 protein]; Linoleic Acid promotes the reaction [TNF protein results in increased activity of CASP3 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of ANXA5 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of CASP3 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of ANXA5 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]; TNF protein promotes the reaction [Linoleic Acid results in increased activity of ANXA5 protein]; TNF protein promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of ANXA5 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of CASP3 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of ANXA5 protein]]]; Zinc Acetate promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]] CTD PMID:10617950 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 increases expression
multiple interactions
EXP Linoleic Acid results in increased expression of VCAM1 mRNA
[Linoleic Acid co-treated with Polychlorinated Biphenyls] results in increased expression of VCAM1 protein; Linoleic Acid promotes the reaction [Polychlorinated Biphenyls results in increased expression of VCAM1 mRNA]; prolinedithiocarbamate inhibits the reaction [Linoleic Acid results in increased expression of VCAM1 mRNA]; Quercetin inhibits the reaction [Linoleic Acid results in increased expression of VCAM1 mRNA]
CTD PMID:15051824, PMID:18155686 NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,908...117,511,226
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 880
    chemical entity 880
      atom 865
        nonmetal atom 845
          carbon atom 826
            organic molecular entity 826
              lipid 237
                fatty acid 77
                  unsaturated fatty acid 9
                    polyunsaturated fatty acid 9
                      omega-6 fatty acid 8
                        (10Z,13Z,16Z)-docosatrienoic acid + 0
                        (10Z,13Z,16Z,19Z,22Z)-octacosapentaenoic acid + 0
                        (11Z,14Z,17Z,20Z)-hexacosatetraenoic acid + 0
                        (12Z,15Z,18Z,21Z,24Z)-triacontapentaenoic acid + 0
                        (13Z,16Z,19Z,22Z)-octacosatetraenoic acid + 0
                        (14Z,17Z,20Z,23Z,26Z)-dotriacontapentaenoic acid + 0
                        (15Z,18Z,21Z,24Z)-triacontatetraenoic acid + 0
                        (16Z,19Z,22Z,25Z,28Z)-tetratriacontapentaenoic acid + 0
                        (17Z,20Z,23Z,26Z)-dotriacontatetraenoic acid + 0
                        (18Z,21Z,24Z,27Z,30Z)-hexatriacontapentaenoic acid + 0
                        (19Z,22Z,25Z,28Z)-tetratriacontatetraenoic acid + 0
                        (20Z,23Z,26Z,29Z,32Z)-octatriacontapentaenoic acid + 0
                        (21Z,24Z,27Z,30Z)-hexatriacontatetraenoic acid + 0
                        (23Z,26Z,29Z,32Z)-octatriacontatetraenoic acid + 0
                        (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoic acid + 0
                        (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoic acid + 0
                        (8E,10E,12Z)-octadecatrienoic acid + 0
                        (8Z,11Z,14Z,17Z,20Z)-hexacosapentaenoic acid + 0
                        (9Z,12Z,15Z,18Z)-tetracosatetraenoic acid + 0
                        all-cis-docosa-7,10,13,16-tetraenoic acid + 0
                        arachidonic acid + 0
                        cis-4-decenoic acid + 0
                        fatty acid 18:3-omega-3omega-6 0
                        fatty acid 20:3-omega-3omega-6 0
                        fatty acid 20:4-omega-6 0
                        fatty acid 22:5-omega-6 0
                        gamma-linolenic acid + 0
                        linoelaidic acid 0
                        linoleic acid + 8
                        lysophosphatidylcholine 0:0/20:3-omega-3omega-6 0
                        lysophosphatidylcholine 18:3-omega-3omega-6 + 0
                        lysophosphatidylcholine 18:3-omega-3omega-6/0:0 0
                        lysophosphatidylcholine 20:3-omega-3omega-6 + 0
                        lysophosphatidylcholine 20:3-omega-3omega-6/0:0 0
                        lysophosphatidylcholine 22:5-omega-6 0
                        lysophosphatidylcholine 22:5-omega-6/0:0 0
                        lysophosphatidylethanolamine 20:3-omega-3omega-6 0
                        lysophosphatidylethanolamine 22:5-omega-6 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 880
    subatomic particle 865
      composite particle 865
        hadron 865
          baryon 865
            nucleon 865
              atomic nucleus 865
                atom 865
                  main group element atom 855
                    p-block element atom 852
                      carbon group element atom 827
                        carbon atom 826
                          organic molecular entity 826
                            organic group 391
                              organic divalent group 389
                                organodiyl group 389
                                  carbonyl group 388
                                    carbonyl compound 388
                                      carboxylic acid 267
                                        monocarboxylic acid 134
                                          fatty acid 77
                                            unsaturated fatty acid 9
                                              polyunsaturated fatty acid 9
                                                essential fatty acid 8
                                                  omega-6 fatty acid 8
                                                    (10Z,13Z,16Z)-docosatrienoic acid + 0
                                                    (10Z,13Z,16Z,19Z,22Z)-octacosapentaenoic acid + 0
                                                    (11Z,14Z,17Z,20Z)-hexacosatetraenoic acid + 0
                                                    (12Z,15Z,18Z,21Z,24Z)-triacontapentaenoic acid + 0
                                                    (13Z,16Z,19Z,22Z)-octacosatetraenoic acid + 0
                                                    (14Z,17Z,20Z,23Z,26Z)-dotriacontapentaenoic acid + 0
                                                    (15Z,18Z,21Z,24Z)-triacontatetraenoic acid + 0
                                                    (16Z,19Z,22Z,25Z,28Z)-tetratriacontapentaenoic acid + 0
                                                    (17Z,20Z,23Z,26Z)-dotriacontatetraenoic acid + 0
                                                    (18Z,21Z,24Z,27Z,30Z)-hexatriacontapentaenoic acid + 0
                                                    (19Z,22Z,25Z,28Z)-tetratriacontatetraenoic acid + 0
                                                    (20Z,23Z,26Z,29Z,32Z)-octatriacontapentaenoic acid + 0
                                                    (21Z,24Z,27Z,30Z)-hexatriacontatetraenoic acid + 0
                                                    (23Z,26Z,29Z,32Z)-octatriacontatetraenoic acid + 0
                                                    (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoic acid + 0
                                                    (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoic acid + 0
                                                    (8E,10E,12Z)-octadecatrienoic acid + 0
                                                    (8Z,11Z,14Z,17Z,20Z)-hexacosapentaenoic acid + 0
                                                    (9Z,12Z,15Z,18Z)-tetracosatetraenoic acid + 0
                                                    all-cis-docosa-7,10,13,16-tetraenoic acid + 0
                                                    arachidonic acid + 0
                                                    cis-4-decenoic acid + 0
                                                    fatty acid 18:3-omega-3omega-6 0
                                                    fatty acid 20:3-omega-3omega-6 0
                                                    fatty acid 20:4-omega-6 0
                                                    fatty acid 22:5-omega-6 0
                                                    gamma-linolenic acid + 0
                                                    linoelaidic acid 0
                                                    linoleic acid + 8
                                                    lysophosphatidylcholine 0:0/20:3-omega-3omega-6 0
                                                    lysophosphatidylcholine 18:3-omega-3omega-6 + 0
                                                    lysophosphatidylcholine 18:3-omega-3omega-6/0:0 0
                                                    lysophosphatidylcholine 20:3-omega-3omega-6 + 0
                                                    lysophosphatidylcholine 20:3-omega-3omega-6/0:0 0
                                                    lysophosphatidylcholine 22:5-omega-6 0
                                                    lysophosphatidylcholine 22:5-omega-6/0:0 0
                                                    lysophosphatidylethanolamine 20:3-omega-3omega-6 0
                                                    lysophosphatidylethanolamine 22:5-omega-6 0
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