Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:omega-6 fatty acid
go back to main search page
Accession:CHEBI:36009 term browser browse the term
Definition:A family of polyunsaturated fatty acids that have in common a final carbon-carbon double bond in the n-6 position, i.e., the sixth bond from the methyl end of the fatty acid.
Synonyms:related_synonym: omega-6 fatty acids
 alt_id: MESH:D043371
 xref_mesh: MESH:D043371
 xref: PMID:19035453;   PMID:19136835


show annotations for term's descendants           Sort by:
 
omega-6 fatty acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alg3 asparagine-linked glycosylation 3 (alpha-1,3-mannosyltransferase) decreases expression ISO Fatty Acids, Omega-6 results in decreased expression of ALG3 mRNA CTD PMID:16823509 NCBI chr16:20,605,458...20,610,761
Ensembl chr16:20,605,374...20,611,735
JBrowse link
G Atp8a1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 increases expression ISO Fatty Acids, Omega-6 results in increased expression of ATP8A1 mRNA CTD PMID:16823509 NCBI chr 5:67,618,139...67,847,484
Ensembl chr 5:67,618,140...67,847,434
JBrowse link
G Ccnd1 cyclin D1 affects response to substance ISO CCND1 gene SNP affects the susceptibility to Fatty Acids, Omega-6 CTD PMID:15845652 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Cd84 CD84 antigen decreases expression ISO Fatty Acids, Omega-6 results in decreased expression of CD84 mRNA CTD PMID:16823509 NCBI chr 1:171,839,697...171,890,718
Ensembl chr 1:171,839,697...171,890,718
JBrowse link
G Cpb2 carboxypeptidase B2 (plasma) increases expression ISO Fatty Acids, Omega-6 results in increased expression of CPB2 mRNA CTD PMID:16823509 NCBI chr14:75,242,287...75,283,555
Ensembl chr14:75,242,287...75,283,555
JBrowse link
G Dgke diacylglycerol kinase, epsilon increases expression ISO Fatty Acids, Omega-6 results in increased expression of DGKE mRNA CTD PMID:16823509 NCBI chr11:89,035,179...89,060,795
Ensembl chr11:89,035,179...89,066,850
JBrowse link
G Dusp2 dual specificity phosphatase 2 increases expression ISO Fatty Acids, Omega-6 results in increased expression of DUSP2 mRNA CTD PMID:16823509 NCBI chr 2:127,336,159...127,338,377
Ensembl chr 2:127,336,159...127,338,376
JBrowse link
G Ebi3 Epstein-Barr virus induced gene 3 decreases expression ISO Fatty Acids, Omega-6 results in decreased expression of EBI3 mRNA CTD PMID:16823509 NCBI chr17:55,952,623...55,957,022
Ensembl chr17:55,952,640...55,957,022
JBrowse link
G Gars glycyl-tRNA synthetase decreases expression ISO Fatty Acids, Omega-6 results in decreased expression of GARS1 mRNA CTD PMID:16823509 NCBI chr 6:55,038,001...55,079,504
Ensembl chr 6:55,038,007...55,079,500
JBrowse link
G Gjc1 gap junction protein, gamma 1 increases expression ISO Fatty Acids, Omega-6 results in increased expression of GJC1 mRNA CTD PMID:16823509 NCBI chr11:102,799,477...102,819,686
Ensembl chr11:102,799,579...102,819,700
JBrowse link
G Hs3st1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 increases expression ISO Fatty Acids, Omega-6 results in increased expression of HS3ST1 mRNA CTD PMID:16823509 NCBI chr 5:39,613,935...39,645,592
Ensembl chr 5:39,613,935...39,755,475
JBrowse link
G Il1rap interleukin 1 receptor accessory protein increases expression ISO Fatty Acids, Omega-6 results in increased expression of IL1RAP mRNA CTD PMID:16823509 NCBI chr16:26,581,509...26,730,128
Ensembl chr16:26,581,704...26,730,117
JBrowse link
G Itgb4 integrin beta 4 increases expression ISO Fatty Acids, Omega-6 results in increased expression of ITGB4 mRNA CTD PMID:16823509 NCBI chr11:115,974,725...116,008,412
Ensembl chr11:115,974,709...116,008,412
JBrowse link
G Kif4 kinesin family member 4 increases expression ISO Fatty Acids, Omega-6 results in increased expression of KIF4A mRNA CTD PMID:16823509 NCBI chr  X:100,626,065...100,727,271
Ensembl chr  X:100,625,737...100,727,214
JBrowse link
G Msln mesothelin increases expression ISO Fatty Acids, Omega-6 results in increased expression of MSLN mRNA CTD PMID:16823509 NCBI chr17:25,748,613...25,754,378
Ensembl chr17:25,748,613...25,754,378
JBrowse link
G Nudcd3 NudC domain containing 3 increases expression ISO Fatty Acids, Omega-6 results in increased expression of NUDCD3 mRNA CTD PMID:16823509 NCBI chr11:6,105,691...6,201,619
Ensembl chr11:6,105,691...6,200,415
JBrowse link
G Pcdh1 protocadherin 1 increases expression ISO Fatty Acids, Omega-6 results in increased expression of PCDH1 mRNA CTD PMID:16823509 NCBI chr18:38,185,914...38,212,048
Ensembl chr18:38,185,914...38,212,053
JBrowse link
G Phkg1 phosphorylase kinase gamma 1 decreases expression ISO Fatty Acids, Omega-6 results in decreased expression of PHKG1 mRNA CTD PMID:16823509 NCBI chr 5:129,863,431...129,879,134
Ensembl chr 5:129,863,421...129,898,549
JBrowse link
G Psmd11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 increases expression ISO Fatty Acids, Omega-6 results in increased expression of PSMD11 mRNA CTD PMID:16823509 NCBI chr11:80,428,615...80,473,248
Ensembl chr11:80,428,615...80,473,248
JBrowse link
G Puf60 poly-U binding splicing factor 60 decreases expression ISO Fatty Acids, Omega-6 results in decreased expression of PUF60 mRNA CTD PMID:16823509 NCBI chr15:76,070,182...76,082,537
Ensembl chr15:76,070,182...76,080,924
JBrowse link
G Ro60 Ro60, Y RNA binding protein decreases expression ISO Fatty Acids, Omega-6 results in decreased expression of RO60 mRNA CTD PMID:16823509 NCBI chr 1:143,750,790...143,777,063
Ensembl chr 1:143,750,790...143,777,068
JBrowse link
G Sdc4 syndecan 4 increases expression ISO Fatty Acids, Omega-6 results in increased expression of SDC4 mRNA CTD PMID:16823509 NCBI chr 2:164,424,247...164,443,188
Ensembl chr 2:164,424,247...164,443,887
JBrowse link
G Slc1a6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 decreases expression ISO Fatty Acids, Omega-6 results in decreased expression of SLC1A6 mRNA CTD PMID:16823509 NCBI chr10:78,780,086...78,814,825
Ensembl chr10:78,780,496...78,814,765
JBrowse link
G Slc26a4 solute carrier family 26, member 4 decreases expression ISO Fatty Acids, Omega-6 results in decreased expression of SLC26A4 mRNA CTD PMID:16823509 NCBI chr12:31,519,814...31,560,055
Ensembl chr12:31,519,827...31,559,969
JBrowse link
G Soat1 sterol O-acyltransferase 1 increases expression ISO Fatty Acids, Omega-6 results in increased expression of SOAT1 mRNA CTD PMID:16823509 NCBI chr 1:156,428,108...156,474,328
Ensembl chr 1:156,424,525...156,474,331
JBrowse link
G Urb1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae) decreases expression ISO Fatty Acids, Omega-6 results in decreased expression of URB1 mRNA CTD PMID:16823509 NCBI chr16:90,751,527...90,810,467
Ensembl chr16:90,751,527...90,810,413
JBrowse link
G Vti1b vesicle transport through interaction with t-SNAREs 1B increases expression ISO Fatty Acids, Omega-6 results in increased expression of VTI1B mRNA CTD PMID:16823509 NCBI chr12:79,156,017...79,172,685
Ensembl chr12:79,156,017...79,172,667
JBrowse link
(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crp C-reactive protein, pentraxin-related affects expression ISO docosapentaenoic acid affects the expression of CRP protein CTD PMID:22113248 NCBI chr 1:172,698,056...172,699,966
Ensembl chr 1:172,698,055...172,833,031
JBrowse link
G Pla2g6 phospholipase A2, group VI multiple interactions ISO docosapentaenoic acid inhibits the reaction [Ethanol results in decreased expression of PLA2G6 protein] CTD PMID:25029343 NCBI chr15:79,286,228...79,328,385
Ensembl chr15:79,286,228...79,328,390
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
ISO docosapentaenoic acid results in decreased expression of PTGS2 protein
docosapentaenoic acid inhibits the reaction [Dimethoate results in increased expression of PTGS2 protein]
CTD PMID:22476691 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Rxra retinoid X receptor alpha affects binding ISO docosapentaenoic acid binds to RXRA protein CTD PMID:16258897 NCBI chr 2:27,676,445...27,763,319
Ensembl chr 2:27,676,440...27,762,957
JBrowse link
1,2,3-trilinoleoylglycerol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP-binding cassette, sub-family A (ABC1), member 1 decreases expression EXP trilinolein results in decreased expression of ABCA1 mRNA CTD PMID:18356535 NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 decreases expression EXP trilinolein results in decreased expression of ABCG5 mRNA CTD PMID:18356535 NCBI chr17:84,658,174...84,683,011
Ensembl chr17:84,658,234...84,683,011
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 decreases expression EXP trilinolein results in decreased expression of ABCG8 mRNA CTD PMID:18356535 NCBI chr17:84,676,302...84,700,333
Ensembl chr17:84,676,302...84,700,333
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression EXP trilinolein results in decreased expression of CYP27A1 mRNA CTD PMID:18356535 NCBI chr 1:74,713,148...74,737,897
Ensembl chr 1:74,713,574...74,737,892
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase increases expression EXP trilinolein results in increased expression of HMGCR mRNA CTD PMID:18356535 NCBI chr13:96,648,962...96,670,936
Ensembl chr13:96,648,967...96,670,936
JBrowse link
G Mttp microsomal triglyceride transfer protein increases expression EXP trilinolein results in increased expression of MTTP mRNA CTD PMID:18356535 NCBI chr 3:138,089,855...138,143,418
Ensembl chr 3:138,089,854...138,144,968
JBrowse link
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 decreases expression EXP trilinolein results in decreased expression of NPC1L1 mRNA CTD PMID:18356535 NCBI chr11:6,211,011...6,230,245
Ensembl chr11:6,211,013...6,230,143
JBrowse link
G Scd1 stearoyl-Coenzyme A desaturase 1 multiple interactions
decreases expression
EXP Clofibrate inhibits the reaction [trilinolein results in decreased expression of SCD1 mRNA] CTD PMID:8790349 NCBI chr19:44,394,450...44,407,709
Ensembl chr19:44,394,455...44,407,879
JBrowse link
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fech ferrochelatase affects abundance EXP FECH protein affects the abundance of 1-palmitoyl-2-linoleoylphosphatidylcholine CTD PMID:29906468 NCBI chr18:64,456,542...64,489,098
Ensembl chr18:64,452,914...64,490,251
JBrowse link
1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lipg lipase, endothelial increases hydrolysis ISO LIPG protein results in increased hydrolysis of 1-O-hexadecyl-2-arachidonyl-sn-glycero-3-phosphocholine CTD PMID:15953354 NCBI chr18:74,939,322...74,961,263
Ensembl chr18:74,939,322...74,961,263
JBrowse link
1-stearoyl-2-arachidonoyl-sn-glycerol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dagla diacylglycerol lipase, alpha increases metabolic processing ISO DAGLA protein results in increased metabolism of 1-stearoyl-2-arachidonoylglycerol CTD PMID:18657971 NCBI chr19:10,245,265...10,304,877
Ensembl chr19:10,245,265...10,304,877
JBrowse link
G Daglb diacylglycerol lipase, beta increases metabolic processing ISO DAGLB protein results in increased metabolism of 1-stearoyl-2-arachidonoylglycerol CTD PMID:18657971 NCBI chr 5:143,464,484...143,504,442
Ensembl chr 5:143,464,584...143,505,942
JBrowse link
G Dgke diacylglycerol kinase, epsilon increases phosphorylation ISO DGKE protein results in increased phosphorylation of 1-stearoyl-2-arachidonoylglycerol CTD PMID:17455907 NCBI chr11:89,035,179...89,060,795
Ensembl chr11:89,035,179...89,066,850
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha increases expression ISO 1-stearoyl-2-arachidonoylglycerol results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr 5:51,454,249...52,115,853
Ensembl chr 5:51,454,250...51,567,726
JBrowse link
G Trpm6 transient receptor potential cation channel, subfamily M, member 6 multiple interactions ISO TRPM6 protein affects the reaction [1-stearoyl-2-arachidonoylglycerol results in increased transport of Barium]; TRPM6 protein affects the reaction [1-stearoyl-2-arachidonoylglycerol results in increased transport of Calcium] CTD PMID:11988098 NCBI chr19:18,730,177...18,892,521
Ensembl chr19:18,749,983...18,892,511
JBrowse link
1-stearoyl-2-linoleoyl-sn-glycerol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lipc lipase, hepatic decreases abundance EXP LIPC gene mutant form results in decreased abundance of 1-stearoyl-2-linoleoyl-sn-glycerol CTD PMID:24777581 NCBI chr 9:70,798,128...70,952,221
Ensembl chr 9:70,798,128...70,952,226
JBrowse link
G Lipg lipase, endothelial decreases abundance EXP LIPG gene mutant form results in decreased abundance of 1-stearoyl-2-linoleoyl-sn-glycerol CTD PMID:24777581 NCBI chr18:74,939,322...74,961,263
Ensembl chr18:74,939,322...74,961,263
JBrowse link
13-HPODE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase increases expression EXP
ISO
13-hydroperoxy-9,11-octadecadienoic acid results in increased expression of CAT protein CTD PMID:10946007 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Cav1 caveolin 1, caveolae protein increases expression ISO 13-hydroperoxy-9,11-octadecadienoic acid results in increased expression of CAV1 mRNA CTD PMID:27257344 NCBI chr 6:17,306,335...17,341,328
Ensembl chr 6:17,306,335...17,341,452
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 multiple interactions ISO [13-hydroperoxy-9,11-octadecadienoic acid co-treated with 2-chloro-5-nitrobenzanilide] results in increased expression of CCL2 mRNA; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with 2-chloro-5-nitrobenzanilide] results in increased expression of CCL2 protein; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with MK-886] results in increased expression of CCL2 mRNA; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with MK-886] results in increased expression of CCL2 protein CTD PMID:22135674 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO [13-hydroperoxy-9,11-octadecadienoic acid co-treated with 2-chloro-5-nitrobenzanilide] results in increased expression of EGR1 mRNA; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with 2-chloro-5-nitrobenzanilide] results in increased expression of EGR1 protein; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with MK-886] results in increased expression of EGR1 mRNA; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with MK-886] results in increased expression of EGR1 protein CTD PMID:22135674 NCBI chr18:34,861,207...34,864,956
Ensembl chr18:34,859,823...34,864,984
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO 13-hydroperoxy-9,11-octadecadienoic acid results in increased expression of PPARA protein CTD PMID:22135674 NCBI chr15:85,734,910...85,806,851
Ensembl chr15:85,734,983...85,802,819
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma increases expression ISO 13-hydroperoxy-9,11-octadecadienoic acid results in increased expression of PPARG protein CTD PMID:22135674 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
14,15-EET term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 decreases activity ISO 14,15-epoxy-5,8,11-eicosatrienoic acid analog results in decreased activity of ACE protein CTD PMID:27428043 NCBI chr11:105,967,948...105,989,964
Ensembl chr11:105,967,945...105,989,964
JBrowse link
G Ace2 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 multiple interactions EXP 14,15-epoxy-5,8,11-eicosatrienoic acid analog promotes the reaction [REN2 protein results in increased expression of ACE2 protein] CTD PMID:27428043 NCBI chr  X:164,139,342...164,188,418
Ensembl chr  X:164,139,332...164,188,420
JBrowse link
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) multiple interactions
decreases expression
increases cleavage
EXP
ISO
14,15-epoxy-5,8,11-eicosatrienoic acid analog inhibits the reaction [REN2 protein results in increased expression of AGT protein modified form]
14,15-epoxy-5,8,11-eicosatrienoic acid analog results in decreased expression of AGT protein modified form
[14,15-epoxy-5,8,11-eicosatrienoic acid analog results in increased cleavage of AGT protein modified form] which results in increased abundance of angiotensin I (1-7)
CTD PMID:27428043 NCBI chr 8:124,556,587...124,569,706
Ensembl chr 8:124,556,534...124,569,706
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 increases phosphorylation ISO 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of AKT1 protein CTD PMID:16286479 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 increases chemical synthesis ISO CYP2C8 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid CTD PMID:12675279 NCBI chr19:39,287,044...39,330,713
Ensembl chr19:39,269,405...39,330,713
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 increases chemical synthesis
multiple interactions
ISO CYP2C9 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid
Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid]
CTD PMID:12675279 NCBI chr19:39,061,006...39,093,948
Ensembl chr19:39,061,015...39,093,944
JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 increases chemical synthesis
multiple interactions
ISO CYP2C9 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid
Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid]
CTD PMID:12675279 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072
JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 increases chemical synthesis
multiple interactions
ISO CYP3A4 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid
Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid]
CTD PMID:12675279 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964
JBrowse link
G Ephx2 epoxide hydrolase 2, cytoplasmic multiple interactions
increases abundance
EXP [Arsenites results in increased expression of and results in increased activity of EPHX2 protein] which results in decreased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid; [Mercuric Chloride results in increased expression of and results in increased activity of EPHX2 protein] which results in decreased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid
EPHX2 gene mutant form results in increased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid
CTD PMID:19896470, PMID:22680237, PMID:24472606 NCBI chr14:66,084,372...66,124,522
Ensembl chr14:66,084,374...66,124,500
JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression ISO 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased expression of FGF2 protein CTD PMID:16286479 NCBI chr 3:37,348,477...37,410,106
Ensembl chr 3:37,348,346...37,410,108
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases phosphorylation EXP 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of MAPK1 protein CTD PMID:19464254 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases phosphorylation EXP 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of MAPK3 protein CTD PMID:19464254 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Ren2 renin 2 tandem duplication of Ren1 multiple interactions EXP 14,15-epoxy-5,8,11-eicosatrienoic acid analog inhibits the reaction [REN2 protein results in increased expression of AGT protein modified form]; 14,15-epoxy-5,8,11-eicosatrienoic acid analog inhibits the reaction [REN2 protein results in increased transport of 8-epi-prostaglandin F2alpha]; 14,15-epoxy-5,8,11-eicosatrienoic acid analog promotes the reaction [REN2 protein results in increased abundance of angiotensin I (1-7)]; 14,15-epoxy-5,8,11-eicosatrienoic acid analog promotes the reaction [REN2 protein results in increased expression of ACE2 protein]; 14,15-epoxy-5,8,11-eicosatrienoic acid analog promotes the reaction [REN2 protein results in increased transport of Nitrogen Oxides] CTD PMID:27428043
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 increases phosphorylation ISO 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of RPS6KB1 protein CTD PMID:16286479 NCBI chr11:86,498,869...86,544,885
Ensembl chr11:86,498,871...86,544,805
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases secretion
ISO 12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [TGFB1 protein results in decreased secretion of 14,15-epoxy-5,8,11-eicosatrienoic acid] CTD PMID:28694203 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
19(S)-HETE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects metabolic processing ISO CYP2E1 protein affects the metabolism of 19-hydroxy-5,8,11,14-eicosatetraenoic acid CTD PMID:15205388 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Cyp4a31 cytochrome P450, family 4, subfamily a, polypeptide 31 increases chemical synthesis ISO CYP4A11 protein results in increased chemical synthesis of 19-hydroxy-5,8,11,14-eicosatetraenoic acid CTD PMID:30259074 NCBI chr 4:115,563,627...115,579,015
Ensembl chr 4:115,563,649...115,579,015
JBrowse link
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 increases chemical synthesis ISO CYP4F3 protein alternative form results in increased chemical synthesis of 19-hydroxy-5,8,11,14-eicosatetraenoic acid CTD PMID:30259074 NCBI chr 8:71,988,482...72,009,668
Ensembl chr 8:71,988,482...72,009,626
JBrowse link
19-HETE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects metabolic processing ISO CYP2E1 protein affects the metabolism of 19-hydroxy-5,8,11,14-eicosatetraenoic acid CTD PMID:15205388 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Cyp4a31 cytochrome P450, family 4, subfamily a, polypeptide 31 increases chemical synthesis ISO CYP4A11 protein results in increased chemical synthesis of 19-hydroxy-5,8,11,14-eicosatetraenoic acid CTD PMID:30259074 NCBI chr 4:115,563,627...115,579,015
Ensembl chr 4:115,563,649...115,579,015
JBrowse link
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 increases chemical synthesis ISO CYP4F3 protein alternative form results in increased chemical synthesis of 19-hydroxy-5,8,11,14-eicosatetraenoic acid CTD PMID:30259074 NCBI chr 8:71,988,482...72,009,668
Ensembl chr 8:71,988,482...72,009,626
JBrowse link
2-arachidonoylglycerol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd12 abhydrolase domain containing 12 increases hydrolysis EXP ABHD12 protein results in increased hydrolysis of glyceryl 2-arachidonate CTD PMID:18096503 NCBI chr 2:150,832,493...150,904,779
Ensembl chr 2:150,832,493...150,904,741
JBrowse link
G Abhd6 abhydrolase domain containing 6 increases hydrolysis EXP ABHD6 protein results in increased hydrolysis of glyceryl 2-arachidonate CTD PMID:18096503 NCBI chr14:8,002,888...8,056,773
Ensembl chr14:8,002,902...8,056,763
JBrowse link
G Acta2 actin, alpha 2, smooth muscle, aorta increases expression
multiple interactions
ISO glyceryl 2-arachidonate results in increased expression of ACTA2 mRNA
Acetaldehyde promotes the reaction [glyceryl 2-arachidonate results in increased expression of ACTA2 mRNA]
CTD PMID:21863215 NCBI chr19:34,240,336...34,255,585
Ensembl chr19:34,241,090...34,255,590
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 increases expression ISO glyceryl 2-arachidonate results in increased expression of CCL2 protein CTD PMID:15115777 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Ces1d carboxylesterase 1D increases hydrolysis
multiple interactions
ISO CES1 protein results in increased hydrolysis of glyceryl 2-arachidonate
[CES1 protein results in increased hydrolysis of glyceryl 2-arachidonate] which results in increased chemical synthesis of Arachidonic Acid
CTD PMID:21049984 NCBI chr 8:93,166,072...93,197,804
Ensembl chr 8:93,166,068...93,197,838
JBrowse link
G Ces2h carboxylesterase 2H increases hydrolysis
multiple interactions
ISO CES2 protein results in increased hydrolysis of glyceryl 2-arachidonate
[CES2 protein results in increased hydrolysis of glyceryl 2-arachidonate] which results in increased chemical synthesis of Arachidonic Acid
CTD PMID:21049984 NCBI chr 8:105,000,830...105,020,410
Ensembl chr 8:105,000,853...105,021,178
JBrowse link
G Cnr1 cannabinoid receptor 1 (brain) multiple interactions
increases expression
EXP
ISO
CNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP27A1 mRNA]; CNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP7A1 mRNA]; CNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP7B1 mRNA]; CNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP8B1 mRNA]; CNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; CNR1 protein affects the reaction [glyceryl 2-arachidonate inhibits the reaction [Sulfur Dioxide results in increased expression of PTGS2 protein]]
CNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP27A1 mRNA]; CNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP7A1 mRNA]; CNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP8B1 mRNA]
glyceryl 2-arachidonate results in increased expression of CNR1 mRNA
Acetaldehyde promotes the reaction [glyceryl 2-arachidonate results in increased expression of CNR1 mRNA]; Nitroglycerin affects the reaction [glyceryl 2-arachidonate affects the activity of CNR1 protein]
CTD PMID:12657697, PMID:15899896, PMID:16775503, PMID:21863215, PMID:23894352, PMID:26209559 NCBI chr 4:33,923,171...33,948,831
Ensembl chr 4:33,924,593...33,948,831
JBrowse link
G Cnr2 cannabinoid receptor 2 (macrophage) multiple interactions
affects response to substance
ISO [SR 144528 binds to and results in increased activity of CNR2 protein] inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CXCL8 protein]; CNR2 protein affects the reaction [glyceryl 2-arachidonate results in increased expression of CXCL8 protein]; CNR2 protein affects the reaction [glyceryl 2-arachidonate results in increased transport of Calcium]; Pertussis Toxin inhibits the reaction [CNR2 protein affects the reaction [glyceryl 2-arachidonate results in increased transport of Calcium]]; SR 144528 inhibits the reaction [CNR2 protein affects the reaction [glyceryl 2-arachidonate results in increased transport of Calcium]]
CNR2 gene SNP affects the susceptibility to glyceryl 2-arachidonate
CTD PMID:10617657, PMID:15115777, PMID:20124950 NCBI chr 4:135,895,189...135,920,219
Ensembl chr 4:135,895,394...135,920,207
JBrowse link
G Creb3l3 cAMP responsive element binding protein 3-like 3 multiple interactions
increases expression
ISO
EXP
glyceryl 2-arachidonate promotes the reaction [CREB3L3 protein binds to CYP27A1 promoter]; glyceryl 2-arachidonate promotes the reaction [CREB3L3 protein binds to CYP7A1 promoter]; INS protein inhibits the reaction [glyceryl 2-arachidonate promotes the reaction [CREB3L3 protein binds to CYP27A1 promoter]]; INS protein inhibits the reaction [glyceryl 2-arachidonate promotes the reaction [CREB3L3 protein binds to CYP7A1 promoter]]; INS protein inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CREB3L3 mRNA] CTD PMID:23894352 NCBI chr10:81,084,329...81,098,872
Ensembl chr10:81,084,324...81,098,874
JBrowse link
G Crh corticotropin releasing hormone increases abundance EXP CRH protein results in increased abundance of glyceryl 2-arachidonate CTD PMID:26821211 NCBI chr 3:19,693,401...19,695,396
Ensembl chr 3:19,693,401...19,695,396
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 increases expression
multiple interactions
ISO glyceryl 2-arachidonate analog results in increased expression of CXCL8 protein; glyceryl 2-arachidonate results in increased expression of CXCL8 protein
[SR 144528 binds to and results in increased activity of CNR2 protein] inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CXCL8 protein]; CNR2 protein affects the reaction [glyceryl 2-arachidonate results in increased expression of CXCL8 protein]
CTD PMID:15115777 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO
EXP
CNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP27A1 mRNA]; glyceryl 2-arachidonate promotes the reaction [CREB3L3 protein binds to CYP27A1 promoter]; INS protein inhibits the reaction [glyceryl 2-arachidonate promotes the reaction [CREB3L3 protein binds to CYP27A1 promoter]]; INS protein inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP27A1 mRNA] CTD PMID:23894352 NCBI chr 1:74,713,148...74,737,897
Ensembl chr 1:74,713,574...74,737,892
JBrowse link
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO
EXP
CNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP7A1 mRNA]; glyceryl 2-arachidonate promotes the reaction [CREB3L3 protein binds to CYP7A1 promoter]; INS protein inhibits the reaction [glyceryl 2-arachidonate promotes the reaction [CREB3L3 protein binds to CYP7A1 promoter]]; INS protein inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP7A1 mRNA] CTD PMID:23894352 NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633
JBrowse link
G Cyp7b1 cytochrome P450, family 7, subfamily b, polypeptide 1 increases expression
multiple interactions
EXP glyceryl 2-arachidonate results in increased expression of CYP7B1 mRNA
CNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP7B1 mRNA]
CTD PMID:23894352 NCBI chr 3:18,071,944...18,243,890
Ensembl chr 3:18,071,950...18,243,338
JBrowse link
G Cyp8b1 cytochrome P450, family 8, subfamily b, polypeptide 1 increases expression
multiple interactions
ISO
EXP
glyceryl 2-arachidonate results in increased expression of CYP8B1 mRNA
CNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP8B1 mRNA]
CTD PMID:23894352 NCBI chr 9:121,914,356...121,916,305
Ensembl chr 9:121,914,356...121,916,305
JBrowse link
G Esrrg estrogen-related receptor gamma increases abundance ISO
EXP
ESRRG protein results in increased abundance of glyceryl 2-arachidonate CTD PMID:31912162 NCBI chr 1:187,608,510...188,214,885
Ensembl chr 1:187,608,791...188,214,885
JBrowse link
G Fmr1 FMRP translational regulator 1 multiple interactions EXP [FMR1 gene mutant form results in increased activity of MGLL] which results in increased degradation of glyceryl 2-arachidonate CTD PMID:20393458 NCBI chr  X:68,678,536...68,717,963
Ensembl chr  X:68,678,541...68,717,963
JBrowse link
G Fyn Fyn proto-oncogene multiple interactions ISO FYN gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; FYN gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:12657697 NCBI chr10:39,369,743...39,565,381
Ensembl chr10:39,368,855...39,565,381
JBrowse link
G Il1b interleukin 1 beta decreases expression EXP glyceryl 2-arachidonate results in decreased expression of IL1B mRNA CTD PMID:16364651 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il2 interleukin 2 multiple interactions ISO glyceryl 2-arachidonate metabolite inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcium Ionophores] results in increased secretion of IL2 protein]; T 0070907 inhibits the reaction [glyceryl 2-arachidonate metabolite inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcium Ionophores] results in increased secretion of IL2 protein]] CTD PMID:21511917 NCBI chr 3:37,120,713...37,125,954
Ensembl chr 3:37,120,523...37,125,959
JBrowse link
G Il6 interleukin 6 decreases expression EXP glyceryl 2-arachidonate results in decreased expression of IL6 mRNA CTD PMID:16364651 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Ins2 insulin II multiple interactions ISO INS protein inhibits the reaction [glyceryl 2-arachidonate promotes the reaction [CREB3L3 protein binds to CYP27A1 promoter]]; INS protein inhibits the reaction [glyceryl 2-arachidonate promotes the reaction [CREB3L3 protein binds to CYP7A1 promoter]]; INS protein inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CREB3L3 mRNA]; INS protein inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP27A1 mRNA]; INS protein inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP7A1 mRNA] CTD PMID:23894352 NCBI chr 7:142,678,656...142,679,726
Ensembl chr 7:142,678,656...142,743,381
JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAP2K1 protein]; glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAP2K1 protein; U 0126 inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAP2K1 protein] CTD PMID:12657697 NCBI chr 9:64,185,769...64,253,605
Ensembl chr 9:64,185,770...64,253,631
JBrowse link
G Map2k2 mitogen-activated protein kinase kinase 2 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAP2K2 protein]; glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAP2K2 protein; U 0126 inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAP2K2 protein] CTD PMID:12657697 NCBI chr10:81,105,913...81,124,697
Ensembl chr10:81,105,915...81,133,975
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions EXP
ISO
CNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK1 protein
8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; FYN gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK1 protein; Rimonabant inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK1 protein]
CTD PMID:12657697 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions EXP
ISO
CNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK3 protein
8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; FYN gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK3 protein; rimonabant inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:12657697 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mgll monoglyceride lipase multiple interactions
increases degradation
increases abundance
increases hydrolysis
ISO
EXP
[Chlorpyrifos results in decreased activity of MGLL protein] which results in increased abundance of glyceryl 2-arachidonate; JZL 184 inhibits the reaction [MGLL protein results in increased hydrolysis of glyceryl 2-arachidonate]
MGLL protein results in increased degradation of glyceryl 2-arachidonate
[FMR1 gene mutant form results in increased activity of MGLL] which results in increased degradation of glyceryl 2-arachidonate; [JZL 184 results in decreased activity of MGLL protein] which results in increased abundance of glyceryl 2-arachidonate
MGLL gene mutant form results in increased abundance of glyceryl 2-arachidonate
CTD PMID:18096503, PMID:20393458, PMID:21507991, PMID:23761300, PMID:25030704, PMID:26209559, PMID:26642910 NCBI chr 6:88,724,412...88,828,360
Ensembl chr 6:88,724,412...88,828,360
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma affects binding
multiple interactions
increases expression
ISO
EXP
glyceryl 2-arachidonate metabolite binds to PPARG protein
glyceryl 2-arachidonate inhibits the reaction [Sulfur Dioxide results in decreased expression of PPARG protein]; PPARG protein affects the reaction [glyceryl 2-arachidonate inhibits the reaction [Sulfur Dioxide results in increased expression of PTGS2 protein]]; PPARG protein affects the reaction [glyceryl 2-arachidonate inhibits the reaction [Sulfur Dioxide results in increased phosphorylation of RELA protein]]
T 0070907 inhibits the reaction [glyceryl 2-arachidonate metabolite results in increased expression of PPARG mRNA]
CTD PMID:21511917, PMID:26209559 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO [Indomethacin results in decreased expression of PTGS1] which results in increased activity of glyceryl 2-arachidonate CTD PMID:17245358 NCBI chr 2:36,216,742...36,258,593
Ensembl chr 2:36,230,426...36,252,272
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases metabolic processing
multiple interactions
ISO
EXP
PTGS2 protein results in increased metabolism of glyceryl 2-arachidonate
2-chloro-5-nitrobenzanilide inhibits the reaction [glyceryl 2-arachidonate inhibits the reaction [Sulfur Dioxide results in increased expression of PTGS2 protein]]; CNR1 protein affects the reaction [glyceryl 2-arachidonate inhibits the reaction [Sulfur Dioxide results in increased expression of PTGS2 protein]]; glyceryl 2-arachidonate inhibits the reaction [Sulfur Dioxide results in increased expression of PTGS2 protein]; PPARG protein affects the reaction [glyceryl 2-arachidonate inhibits the reaction [Sulfur Dioxide results in increased expression of PTGS2 protein]]; Rimonabant inhibits the reaction [glyceryl 2-arachidonate inhibits the reaction [Sulfur Dioxide results in increased expression of PTGS2 protein]]
glyceryl 2-arachidonate inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcium Ionophores] results in increased expression of PTGS2 mRNA]; Ibuprofen inhibits the reaction [PTGS2 protein results in increased metabolism of glyceryl 2-arachidonate]
CTD PMID:18297109, PMID:21511917, PMID:26209559 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP 2-chloro-5-nitrobenzanilide inhibits the reaction [glyceryl 2-arachidonate inhibits the reaction [Sulfur Dioxide results in increased phosphorylation of RELA protein]]; glyceryl 2-arachidonate inhibits the reaction [Sulfur Dioxide results in increased phosphorylation of RELA protein]; PPARG protein affects the reaction [glyceryl 2-arachidonate inhibits the reaction [Sulfur Dioxide results in increased phosphorylation of RELA protein]] CTD PMID:26209559 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
EXP
ISO
glyceryl 2-arachidonate results in decreased expression of TNF mRNA
glyceryl 2-arachidonate inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF protein]
CTD PMID:12509806, PMID:16364651 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions
affects response to substance
ISO glyceryl 2-arachidonate binds to and results in increased activity of TRPV1 protein
TRPV1 protein affects the susceptibility to glyceryl 2-arachidonate
CTD PMID:18550765, PMID:21949157 NCBI chr11:73,234,149...73,261,322
Ensembl chr11:73,234,292...73,261,242
JBrowse link
20-HETE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clock circadian locomotor output cycles kaput affects abundance EXP CLOCK protein affects the abundance of 20-hydroxy-5,8,11,14-eicosatetraenoic acid CTD PMID:22440902 NCBI chr 5:76,209,868...76,305,603
Ensembl chr 5:76,209,868...76,304,792
JBrowse link
G Cyp4a12b cytochrome P450, family 4, subfamily a, polypeptide 12B multiple interactions
increases chemical synthesis
ISO 20-hydroxy-5,8,11,14-eicosatetraenoic acid affects the reaction [CYP4A1 protein affects the susceptibility to Phenylephrine]; 20-hydroxy-5,8,11,14-eicosatetraenoic acid inhibits the reaction [DDMS inhibits the reaction [CYP4A1 protein results in increased susceptibility to Phenylephrine]]
CYP4A1 protein results in increased chemical synthesis of 20-hydroxy-5,8,11,14-eicosatetraenoic acid
CTD PMID:11124159, PMID:12388396 NCBI chr 4:115,411,624...115,439,034
Ensembl chr 4:115,411,624...115,439,034
JBrowse link
G Cyp4a31 cytochrome P450, family 4, subfamily a, polypeptide 31 increases secretion
increases chemical synthesis
multiple interactions
ISO CYP4A11 protein results in increased secretion of 20-hydroxy-5,8,11,14-eicosatetraenoic acid
CYP4A11 protein results in increased chemical synthesis of 20-hydroxy-5,8,11,14-eicosatetraenoic acid
isoliquiritigenin inhibits the reaction [CYP4A11 protein results in increased secretion of 20-hydroxy-5,8,11,14-eicosatetraenoic acid]
CTD PMID:23747687, PMID:30259074 NCBI chr 4:115,563,627...115,579,015
Ensembl chr 4:115,563,649...115,579,015
JBrowse link
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 increases chemical synthesis ISO CYP4F3 protein alternative form results in increased chemical synthesis of 20-hydroxy-5,8,11,14-eicosatetraenoic acid CTD PMID:30259074 NCBI chr 8:71,988,482...72,009,668
Ensembl chr 8:71,988,482...72,009,626
JBrowse link
G Nfatc4 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 multiple interactions
increases localization
ISO Cyclosporine inhibits the reaction [20-hydroxy-5,8,11,14-eicosatetraenoic acid results in increased localization of NFATC4 protein]; Tacrolimus inhibits the reaction [20-hydroxy-5,8,11,14-eicosatetraenoic acid results in increased localization of NFATC4 protein] CTD PMID:16055480 NCBI chr14:55,824,795...55,833,943
Ensembl chr14:55,823,144...55,833,943
JBrowse link
G Pomc pro-opiomelanocortin-alpha multiple interactions
increases abundance
ISO N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine inhibits the reaction [POMC protein affects the abundance of 20-hydroxy-5,8,11,14-eicosatetraenoic acid]
POMC protein results in increased abundance of 20-hydroxy-5,8,11,14-eicosatetraenoic acid
CTD PMID:18067589, PMID:19458537 NCBI chr12:3,954,945...3,960,643
Ensembl chr12:3,954,951...3,960,642
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of 20-hydroxy-5,8,11,14-eicosatetraenoic acid CTD PMID:15231852 NCBI chr 1:88,211,959...88,220,002
Ensembl chr 1:88,211,959...88,218,997
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase 1 family, polypeptide A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of 20-hydroxy-5,8,11,14-eicosatetraenoic acid CTD PMID:15231852 NCBI chr 1:88,166,012...88,220,002
Ensembl chr 1:88,166,012...88,218,997
JBrowse link
G Ugt2b34 UDP glucuronosyltransferase 2 family, polypeptide B34 increases glucuronidation ISO UGT2B7 protein results in increased glucuronidation of 20-hydroxy-5,8,11,14-eicosatetraenoic acid CTD PMID:15231852 NCBI chr 5:86,889,770...86,906,937
Ensembl chr 5:86,889,767...86,906,937
JBrowse link
5,6-EET term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 increases chemical synthesis
multiple interactions
ISO CYP3A4 protein results in increased chemical synthesis of 5,6-epoxy-8,11,14-eicosatrienoic acid
Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 5,6-epoxy-8,11,14-eicosatrienoic acid]
CTD PMID:12675279 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964
JBrowse link
G Ephx2 epoxide hydrolase 2, cytoplasmic increases abundance EXP EPHX2 gene mutant form results in increased abundance of 5,6-epoxy-8,11,14-eicosatrienoic acid CTD PMID:19896470 NCBI chr14:66,084,372...66,124,522
Ensembl chr14:66,084,374...66,124,500
JBrowse link
8,9-EET term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 increases chemical synthesis
multiple interactions
ISO CYP2C9 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid
Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid]
CTD PMID:12675279 NCBI chr19:39,061,006...39,093,948
Ensembl chr19:39,061,015...39,093,944
JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 increases chemical synthesis
multiple interactions
ISO CYP2C9 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid
Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid]
CTD PMID:12675279 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072
JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 multiple interactions
increases chemical synthesis
ISO Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid] CTD PMID:12675279 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964
JBrowse link
G Ephx1 epoxide hydrolase 1, microsomal affects hydrolysis EXP EPHX1 protein affects the hydrolysis of 8,9-epoxyeicosatrienoic acid CTD PMID:28975360 NCBI chr 1:180,989,556...181,017,569
Ensembl chr 1:180,976,210...181,020,904
JBrowse link
G Ephx2 epoxide hydrolase 2, cytoplasmic increases abundance EXP EPHX2 gene mutant form results in increased abundance of 8,9-epoxyeicosatrienoic acid CTD PMID:19896470 NCBI chr14:66,084,372...66,124,522
Ensembl chr14:66,084,374...66,124,500
JBrowse link
AACOCF3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) multiple interactions ISO arachidonyltrifluoromethane inhibits the reaction [AGT protein results in increased abundance of Epoprostenol] CTD PMID:14613874 NCBI chr 8:124,556,587...124,569,706
Ensembl chr 8:124,556,534...124,569,706
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions ISO
EXP
arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CXCL8 mRNA]
arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CXCL15 mRNA]
CTD PMID:18938131, PMID:19063610, PMID:19162293 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:18938131 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 multiple interactions EXP arachidonyltrifluoromethane inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid] CTD PMID:19014389 NCBI chr15:54,838,901...54,952,789
Ensembl chr15:54,838,901...54,952,892
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO arachidonyltrifluoromethane inhibits the reaction [NAD inhibits the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased secretion of IL1B protein]] CTD PMID:29642561 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Ins2 insulin II increases secretion
multiple interactions
ISO arachidonyltrifluoromethane results in increased secretion of INS protein
arachidonyltrifluoromethane inhibits the reaction [Glucose results in increased secretion of INS protein]
CTD PMID:17192482 NCBI chr 7:142,678,656...142,679,726
Ensembl chr 7:142,678,656...142,743,381
JBrowse link
G Lep leptin multiple interactions EXP arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of LEP mRNA] CTD PMID:19063610 NCBI chr 6:29,060,221...29,073,876
Ensembl chr 6:29,060,220...29,073,877
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO arachidonyltrifluoromethane inhibits the reaction [NRG1 protein alternative form results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:15231676 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO arachidonyltrifluoromethane inhibits the reaction [NRG1 protein alternative form results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:15231676 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Nrg1 neuregulin 1 multiple interactions ISO arachidonyltrifluoromethane inhibits the reaction [NRG1 protein alternative form results in increased phosphorylation of and results in increased activity of MAPK1 protein]; arachidonyltrifluoromethane inhibits the reaction [NRG1 protein alternative form results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:15231676 NCBI chr 8:31,807,452...32,891,609
Ensembl chr 8:31,814,551...32,884,797
JBrowse link
G Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) multiple interactions EXP
ISO
arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of PLA2G4A protein]
arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA]
CTD PMID:18938131, PMID:19063610, PMID:19162293 NCBI chr 1:149,829,618...149,961,290
Ensembl chr 1:149,829,618...149,961,290
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions EXP arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PPARG mRNA] CTD PMID:19063610 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP
ISO
arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of PTGS2 protein]; arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]; arachidonyltrifluoromethane promotes the reaction [Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]] CTD PMID:18938131, PMID:19063610, PMID:19162293 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G S100a11 S100 calcium binding protein A11 multiple interactions ISO arachidonyltrifluoromethane inhibits the reaction [S100A11 mutant form results in increased susceptibility to Cisplatin]; arachidonyltrifluoromethane inhibits the reaction [S100A11 mutant form results in increased susceptibility to oxaliplatin] CTD PMID:25940438 NCBI chr 3:93,520,496...93,526,288
Ensembl chr 3:93,520,488...93,526,287
JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions EXP arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA] CTD PMID:19063610 NCBI chr11:117,966,079...117,970,336
Ensembl chr11:117,966,079...117,970,047
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions ISO arachidonyltrifluoromethane inhibits the reaction [TNF protein results in increased expression of SOD2] CTD PMID:11264281 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO arachidonyltrifluoromethane inhibits the reaction [TNF protein results in increased expression of SOD2] CTD PMID:11264281 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO
EXP
arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA]
arachidonyltrifluoromethane promotes the reaction [Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA]]
CTD PMID:19063610, PMID:19162293 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369
JBrowse link
all-cis-docosa-7,10,13,16-tetraenoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rxra retinoid X receptor alpha multiple interactions ISO adrenic acid binds to and results in increased activity of RXRA protein CTD PMID:16258897 NCBI chr 2:27,676,445...27,763,319
Ensembl chr 2:27,676,440...27,762,957
JBrowse link
G Trp53 transformation related protein 53 multiple interactions EXP [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of adrenic acid CTD PMID:30258081 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
anandamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta (A4) precursor protein decreases response to substance ISO anandamide results in decreased susceptibility to APP protein CTD PMID:22233683 NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766
JBrowse link
G Bdkrb1 bradykinin receptor, beta 1 multiple interactions
decreases activity
ISO AM 251 inhibits the reaction [anandamide results in decreased activity of BDKRB1 protein] CTD PMID:19022239 NCBI chr12:105,604,091...105,605,511
Ensembl chr12:105,603,085...105,605,428
JBrowse link
G Cd36 CD36 molecule increases expression ISO anandamide results in increased expression of CD36 mRNA; anandamide results in increased expression of CD36 protein CTD PMID:17360047 NCBI chr 5:17,781,690...17,888,959
Ensembl chr 5:17,781,690...17,888,801
JBrowse link
G Cnr1 cannabinoid receptor 1 (brain) affects activity
affects binding
increases activity
multiple interactions
ISO
EXP
anandamide affects the activity of CNR1 protein
anandamide binds to CNR1 protein
anandamide results in increased activity of CNR1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased activity of CNR1]; CNR1 affects the reaction [TRPV1 affects the susceptibility to anandamide]; Pertussis Toxin inhibits the reaction [anandamide results in increased activity of CNR1]; rimonabant inhibits the reaction [anandamide results in increased activity of CNR1]
[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]; CNR1 gene mutant form inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CNR1 gene mutant form inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; rimonabant inhibits the reaction [[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]]; SR 144528 inhibits the reaction [[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]]
CTD PMID:10871313, PMID:11408034, PMID:11891798, PMID:12657697, PMID:14504685, PMID:15453094, PMID:17557913, PMID:19147270 NCBI chr 4:33,923,171...33,948,831
Ensembl chr 4:33,924,593...33,948,831
JBrowse link
G Cnr2 cannabinoid receptor 2 (macrophage) affects activity
affects binding
multiple interactions
ISO
EXP
anandamide affects the activity of CNR2 protein
anandamide binds to CNR2 protein
anandamide binds to and results in increased activity of CNR2 protein; CNR2 affects the reaction [TRPV1 affects the susceptibility to anandamide]
CTD PMID:10617657, PMID:10688601, PMID:15453094, PMID:19147270 NCBI chr 4:135,895,189...135,920,219
Ensembl chr 4:135,895,394...135,920,207
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO anandamide results in increased expression of DDIT3 mRNA CTD PMID:21949157 NCBI chr10:127,290,793...127,296,291
Ensembl chr10:127,290,774...127,296,288
Ensembl chr10:127,290,774...127,296,288
JBrowse link
G F3 coagulation factor III increases expression
multiple interactions
ISO anandamide results in increased expression of F3 protein
anandamide promotes the reaction [IL1B protein results in increased expression of F3 protein]
CTD PMID:27556861 NCBI chr 3:121,723,537...121,735,052
Ensembl chr 3:121,723,537...121,735,048
JBrowse link
G Faah fatty acid amide hydrolase multiple interactions
increases degradation
affects expression
EXP
ISO
[nimesulide results in decreased expression of PTGS2] promotes the reaction [FAAH affects the metabolism of anandamide]
FAAH protein results in increased degradation of anandamide
[Chlorpyrifos results in decreased activity of FAAH protein] which results in increased abundance of anandamide; [Lipopolysaccharides results in decreased expression of FAAH protein] which results in increased abundance of anandamide; Nitroglycerin promotes the reaction [FAAH protein results in increased degradation of anandamide]
FAAH results in increased degradation of anandamide
anandamide affects the expression of FAAH protein
CTD PMID:11556820, PMID:16131814, PMID:16886060, PMID:19515121, PMID:20702753, PMID:23761300, PMID:26642910 NCBI chr 4:115,996,668...116,018,837
Ensembl chr 4:115,967,145...116,017,926
JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions
increases expression
ISO anandamide inhibits the reaction [Nitroglycerin results in increased expression of FOS protein]; capsazepine inhibits the reaction [anandamide results in increased expression of FOS protein]; resiniferatoxin inhibits the reaction [anandamide results in increased expression of FOS protein]
anandamide results in increased expression of FOS; anandamide results in increased expression of FOS protein
CTD PMID:9748483, PMID:15601931, PMID:19515121 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Ifng interferon gamma multiple interactions ISO anandamide affects the reaction [[Lipopolysaccharides co-treated with IFNG] results in increased secretion of TNF]; anandamide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG] results in increased secretion of IL1B] CTD PMID:12813001 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Igf1 insulin-like growth factor 1 increases expression EXP anandamide results in increased expression of IGF1 protein CTD PMID:17307377 NCBI chr10:87,858,265...87,937,047
Ensembl chr10:87,858,265...87,937,042
JBrowse link
G Il12b interleukin 12b multiple interactions EXP [OMDM-1 cpd co-treated with anandamide] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]; anandamide inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein] CTD PMID:15748152 NCBI chr11:44,400,063...44,414,677
Ensembl chr11:44,400,063...44,414,033
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO
anandamide inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
anandamide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG] results in increased secretion of IL1B]; anandamide promotes the reaction [IL1B protein results in increased expression of F3 protein]
CTD PMID:12813001, PMID:15748152, PMID:27556861 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Lep leptin decreases abundance
decreases activity
decreases transport
ISO LEP protein results in decreased abundance of anandamide
LEP protein results in decreased activity of anandamide
LEP protein results in decreased transport of anandamide
CTD PMID:16154199 NCBI chr 6:29,060,221...29,073,876
Ensembl chr 6:29,060,220...29,073,877
JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAP2K1 protein]; anandamide results in increased phosphorylation of and results in increased activity of MAP2K1 protein; U 0126 inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAP2K1 protein] CTD PMID:12657697 NCBI chr 9:64,185,769...64,253,605
Ensembl chr 9:64,185,770...64,253,631
JBrowse link
G Map2k2 mitogen-activated protein kinase kinase 2 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAP2K2 protein]; anandamide results in increased phosphorylation of and results in increased activity of MAP2K2 protein; U 0126 inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAP2K2 protein] CTD PMID:12657697 NCBI chr10:81,105,913...81,124,697
Ensembl chr10:81,105,915...81,133,975
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
EXP
ISO
anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein; CNR1 gene mutant form inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]
anandamide results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; AM 251 inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein; Hydrogen Peroxide promotes the reaction [anandamide results in increased phosphorylation of MAPK1 protein]; JTE 907 inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Pertussis Toxin inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; wortmannin inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]
8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein; rimonabant inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]
CTD PMID:12657697, PMID:19477951, PMID:21179406 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
EXP
ISO
anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein; CNR1 gene mutant form inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]
anandamide results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; AM 251 inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein; Hydrogen Peroxide promotes the reaction [anandamide results in increased phosphorylation of MAPK3 protein]; JTE 907 inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Pertussis Toxin inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; wortmannin inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]
8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein; rimonabant inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:12657697, PMID:19477951, PMID:21179406 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mmp1a matrix metallopeptidase 1a (interstitial collagenase) increases expression ISO anandamide results in increased expression of MMP1 mRNA CTD PMID:16330497 NCBI chr 9:7,464,141...7,476,869
Ensembl chr 9:7,464,141...7,476,869
JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression ISO anandamide results in increased expression of MMP3 mRNA CTD PMID:16330497 NCBI chr 9:7,445,822...7,455,975
Ensembl chr 9:7,445,822...7,455,975
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
increases expression
ISO N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [anandamide results in increased expression of MMP9 mRNA] CTD PMID:16330497 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP anandamide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; anandamide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:11891798, PMID:15748152 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO anandamide binds to and results in increased activity of PPARA protein CTD PMID:17906680 NCBI chr15:85,734,910...85,806,851
Ensembl chr15:85,734,983...85,802,819
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
increases metabolic processing
ISO
EXP
[nimesulide results in decreased expression of PTGS2] which results in increased activity of anandamide
anandamide results in increased expression of PTGS2 mRNA; anandamide results in increased expression of PTGS2 protein
PTGS2 results in increased metabolism of anandamide
[nimesulide results in decreased expression of PTGS2] promotes the reaction [FAAH affects the metabolism of anandamide]
CTD PMID:16330497, PMID:17245358, PMID:20702753 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 increases expression
multiple interactions
ISO anandamide results in increased expression of TIMP1 mRNA
N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [anandamide results in increased expression of TIMP1 mRNA]
CTD PMID:16330497 NCBI chr  X:20,870,166...20,874,737
Ensembl chr  X:20,870,166...20,874,735
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases abundance
ISO
EXP
anandamide inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF protein]
TNF protein results in increased abundance of anandamide
anandamide affects the reaction [[Lipopolysaccharides co-treated with IFNG] results in increased secretion of TNF]
CTD PMID:12509806, PMID:12813001, PMID:20626112 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions
increases response to substance
increases activity
affects response to substance
affects binding
ISO 3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide inhibits the reaction [anandamide promotes the reaction [TRPV1 protein results in increased uptake of Calcium]]; anandamide binds to and results in increased activity of TRPV1 protein; capsazepine inhibits the reaction [anandamide binds to and results in increased activity of TRPV1 protein]; CNR1 affects the reaction [TRPV1 affects the susceptibility to anandamide]; CNR2 affects the reaction [TRPV1 affects the susceptibility to anandamide]; Egtazic Acid inhibits the reaction [anandamide binds to and results in increased activity of TRPV1 protein]; methyl arachidonylfluorophosphonate promotes the reaction [anandamide binds to and results in increased activity of TRPV1 protein]; N-(2-methyl-3-hydroxyphenyl)-5,8,11,14-eicosatetraenamide inhibits the reaction [anandamide binds to and results in increased activity of TRPV1 protein]; Nitroprusside promotes the reaction [anandamide binds to and results in increased activity of TRPV1 protein]; Phenylmethylsulfonyl Fluoride promotes the reaction [anandamide binds to and results in increased activity of TRPV1 protein]; rimonabant inhibits the reaction [anandamide binds to and results in increased activity of TRPV1 protein]
TRPV1 protein results in increased susceptibility to anandamide
anandamide results in increased activity of TRPV1 protein
3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide inhibits the reaction [anandamide promotes the reaction [TRPV1 protein results in increased uptake of Calcium]]; anandamide binds to and results in increased activity of TRPV1 protein; bisindolylmaleimide inhibits the reaction [anandamide results in increased activity of TRPV1 protein]; Eicosapentaenoic Acid inhibits the reaction [anandamide results in increased activity of TRPV1 protein]; Tetradecanoylphorbol Acetate promotes the reaction [anandamide results in increased activity of TRPV1 protein]
anandamide binds to TRPV1 protein
CTD PMID:11140687, PMID:11278420, PMID:14504685, PMID:15453094, PMID:15601931, PMID:15615864, PMID:17038422, PMID:17913835, PMID:18550765, PMID:21949157 NCBI chr11:73,234,149...73,261,322
Ensembl chr11:73,234,292...73,261,242
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP anandamide results in decreased expression of and results in decreased secretion of VEGFA protein CTD PMID:15313899 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369
JBrowse link
arachidonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP-binding cassette, sub-family A (ABC1), member 1 multiple interactions
increases degradation
ISO Arachidonic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]; Arachidonic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]]
Arachidonic Acid results in increased degradation of ABCA1 protein
CTD PMID:16118212 NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895
JBrowse link
G Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 multiple interactions ISO Arachidonic Acid promotes the reaction [GW 4064 results in increased expression of ABCB11 mRNA] CTD PMID:15307955 NCBI chr 2:69,238,282...69,342,616
Ensembl chr 2:69,238,282...69,342,616
JBrowse link
G Abcd3 ATP-binding cassette, sub-family D (ALD), member 3 decreases expression ISO Arachidonic Acid results in decreased expression of ABCD3 mRNA CTD PMID:16704987 NCBI chr 3:121,758,904...121,815,302
Ensembl chr 3:121,758,774...121,815,302
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 decreases expression ISO Arachidonic Acid results in decreased expression of ABCG1 mRNA CTD PMID:16730733 NCBI chr17:31,057,694...31,117,984
Ensembl chr17:31,057,675...31,117,988
JBrowse link
G Adarb1 adenosine deaminase, RNA-specific, B1 decreases expression ISO Arachidonic Acid results in decreased expression of ADARB1 mRNA CTD PMID:16704987 NCBI chr10:77,290,727...77,418,292
Ensembl chr10:77,290,726...77,418,270
JBrowse link
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) multiple interactions EXP Eicosapentaenoic Acid inhibits the reaction [AGT protein results in increased metabolism of and results in increased abundance of Arachidonic Acid]; Quinacrine inhibits the reaction [AGT protein results in increased metabolism of and results in increased abundance of Arachidonic Acid] CTD PMID:16257180 NCBI chr 8:124,556,587...124,569,706
Ensembl chr 8:124,556,534...124,569,706
JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions ISO AHR affects the reaction [Tetrachlorodibenzodioxin promotes the reaction [PLA2G4A protein results in increased secretion of Arachidonic Acid]] CTD PMID:19162293 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 increases phosphorylation
multiple interactions
EXP Arachidonic Acid results in increased phosphorylation of AKT1 protein
aristolochic acid I inhibits the reaction [Arachidonic Acid results in increased phosphorylation of AKT1 protein]
CTD PMID:19344371 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Alox12 arachidonate 12-lipoxygenase affects response to substance
increases metabolic processing
EXP
ISO
ALOX12 protein affects the susceptibility to Arachidonic Acid
ALOX12 protein results in increased metabolism of Arachidonic Acid
CTD PMID:17027136, PMID:19373248 NCBI chr11:70,241,457...70,255,380
Ensembl chr11:70,241,457...70,255,353
JBrowse link
G Alox12b arachidonate 12-lipoxygenase, 12R type multiple interactions ISO [TP53 protein results in increased expression of ALOX12B mRNA] which results in increased metabolism of Arachidonic Acid CTD PMID:30258081 NCBI chr11:69,157,072...69,169,791
Ensembl chr11:69,156,989...69,169,792
JBrowse link
G Alox15 arachidonate 15-lipoxygenase affects metabolic processing
multiple interactions
increases metabolic processing
ISO
EXP
ALOX15 protein affects the metabolism of Arachidonic Acid
[ALOX15 protein affects the metabolism of Arachidonic Acid] which affects the susceptibility to Acetylcholine; [ALOX15 protein affects the metabolism of Arachidonic Acid] which results in increased abundance of 11,12,15-trihydroxyeicosatrienoic acid; [ALOX15 protein affects the metabolism of Arachidonic Acid] which results in increased abundance of 11,14,15-trihydroxyeicosa-5,8,12-trienoic acid; [ALOX15 protein affects the metabolism of Arachidonic Acid] which results in increased abundance of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; [ALOX15 protein affects the metabolism of Arachidonic Acid] which results in increased abundance of 15-hydroxy-11,12-epoxyeicosatrienoic acid; [ALOX15 protein affects the metabolism of Arachidonic Acid] which results in increased abundance of 15-hydroxy-5,8,11,13-eicosatetraenoic acid; [ALOX15 protein affects the metabolism of Arachidonic Acid] which results in increased abundance of 6-Ketoprostaglandin F1 alpha; [ALOX15 protein affects the metabolism of Arachidonic Acid] which results in increased abundance of Dinoprostone; ALOX15 protein results in increased metabolism of and affects the susceptibility to Arachidonic Acid
ALOX15 protein results in increased metabolism of Arachidonic Acid
[IL4 protein co-treated with Arachidonic Acid] results in increased activity of ALOX15 protein; [IL4 protein co-treated with Arachidonic Acid] results in increased expression of ALOX15 mRNA
CTD PMID:8305483, PMID:11861792, PMID:21193584, PMID:23872364 NCBI chr11:70,344,147...70,390,538
Ensembl chr11:70,344,152...70,352,031
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions
increases metabolic processing
ISO [sodium arsenite co-treated with Platelet Activating Factor co-treated with Arachidonic Acid] results in increased phosphorylation of and results in increased activity of ALOX5 protein; [Sorbitol co-treated with Calcimycin co-treated with Arachidonic Acid] affects the localization of ALOX5 protein; [TP53 protein results in increased expression of ALOX5 mRNA] which results in increased metabolism of Arachidonic Acid; [zileuton results in decreased activity of ALOX5 protein] which affects the abundance of Arachidonic Acid; [zileuton results in decreased activity of ALOX5 protein] which results in decreased susceptibility to Arachidonic Acid; Arachidonic Acid inhibits the reaction [L 708714 binds to ALOX5 protein]; CJ 13610 inhibits the reaction [ALOX5 protein results in increased metabolism of Arachidonic Acid]; zileuton inhibits the reaction [ALOX5 protein results in increased metabolism of Arachidonic Acid] CTD PMID:7577949, PMID:7592874, PMID:9495842, PMID:10779545, PMID:11698504, PMID:18295198, PMID:30258081 NCBI chr 6:116,410,071...116,461,178
Ensembl chr 6:116,410,077...116,461,178
JBrowse link
G Apoa1 apolipoprotein A-I multiple interactions
decreases expression
ISO Arachidonic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]; Arachidonic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]]
Arachidonic Acid results in decreased expression of APOA1 mRNA
CTD PMID:7983038, PMID:16118212 NCBI chr 9:46,228,630...46,230,469
Ensembl chr 9:46,228,580...46,230,466
JBrowse link
G Apoc1 apolipoprotein C-I decreases expression EXP Arachidonic Acid results in decreased expression of APOC1 mRNA CTD PMID:16623957 NCBI chr 7:19,689,480...19,692,659
Ensembl chr 7:19,689,481...19,692,660
JBrowse link
G Apoe apolipoprotein E multiple interactions
decreases response to substance
ISO
EXP
APOE gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]; Aspirin inhibits the reaction [APOE gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]; dazoxiben inhibits the reaction [APOE gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]; tempol inhibits the reaction [APOE gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]
Aspirin inhibits the reaction [APOE gene mutant form results in decreased susceptibility to Arachidonic Acid]; dazoxiben inhibits the reaction [APOE gene mutant form results in decreased susceptibility to Arachidonic Acid]; Indomethacin promotes the reaction [APOE gene mutant form results in decreased susceptibility to Arachidonic Acid]; tempol inhibits the reaction [APOE gene mutant form results in decreased susceptibility to Arachidonic Acid]
CTD PMID:20530721 NCBI chr 7:19,696,244...19,701,310
Ensembl chr 7:19,696,109...19,699,188
JBrowse link
G Aqp3 aquaporin 3 decreases expression ISO Arachidonic Acid results in decreased expression of AQP3 mRNA CTD PMID:16704987 NCBI chr 4:41,092,724...41,098,183
Ensembl chr 4:41,092,722...41,098,183
JBrowse link
G Arhgdia Rho GDP dissociation inhibitor (GDI) alpha increases expression ISO Arachidonic Acid results in increased expression of ARHGDIA mRNA CTD PMID:16704987 NCBI chr11:120,578,099...120,581,624
Ensembl chr11:120,578,104...120,581,624
JBrowse link
G Atf1 activating transcription factor 1 multiple interactions ISO Arachidonic Acid inhibits the reaction [Quercetin results in increased phosphorylation of ATF1 protein] CTD PMID:20551291 NCBI chr15:100,227,859...100,261,248
Ensembl chr15:100,227,819...100,261,244
JBrowse link
G Atf2 activating transcription factor 2 multiple interactions
increases phosphorylation
ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Arachidonic Acid results in increased phosphorylation of ATF2 protein] CTD PMID:19720122 NCBI chr 2:73,816,509...73,892,677
Ensembl chr 2:73,816,509...73,892,639
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Arachidonic Acid results in increased expression of ATF3 mRNA CTD PMID:16704987 NCBI chr 1:191,170,296...191,183,333
Ensembl chr 1:191,170,296...191,218,039
JBrowse link
G Avp arginine vasopressin increases abundance ISO AVP protein results in increased abundance of Arachidonic Acid CTD PMID:11356622 NCBI chr 2:130,580,620...130,582,588
Ensembl chr 2:130,580,620...130,582,554
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO [Arachidonic Acid co-treated with Iron] results in increased expression of BAD protein; Plant Extracts inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in increased expression of BAD protein] CTD PMID:30626086 NCBI chr19:6,941,861...6,951,905
Ensembl chr19:6,941,861...6,951,899
JBrowse link
G Barx1 BarH-like homeobox 1 decreases expression EXP Arachidonic Acid results in decreased expression of BARX1 mRNA CTD PMID:16623957 NCBI chr13:48,663,036...48,666,507
Ensembl chr13:48,662,998...48,666,507
JBrowse link
G Bax BCL2-associated X protein multiple interactions
affects localization
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Arachidonic Acid affects the localization of BAX protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Arachidonic Acid affects the localization of BAX protein]; [Arachidonic Acid co-treated with Iron] results in increased expression of BAX protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Arachidonic Acid affects the localization of BAX protein]; MAPK14 mutant form inhibits the reaction [Arachidonic Acid affects the localization of BAX protein]; MAPK8 mutant form inhibits the reaction [Arachidonic Acid affects the localization of BAX protein]; Plant Extracts inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [Arachidonic Acid affects the localization of BAX protein] CTD PMID:19540902, PMID:19720122, PMID:30626086 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression
multiple interactions
ISO Arachidonic Acid results in decreased expression of BCL2 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2 protein]; [Arachidonic Acid co-treated with Iron] results in decreased expression of BCL2 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2 protein]; MAPK14 mutant form inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2 protein]; MAPK8 mutant form inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2 protein]; resveratrol inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in decreased expression of BCL2 protein]
CTD PMID:19540902, PMID:19620254, PMID:19720122 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bcl2l1 BCL2-like 1 decreases expression
multiple interactions
ISO Arachidonic Acid results in decreased expression of BCL2L1 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2L1 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2L1 protein]; [Arachidonic Acid co-treated with Iron] results in decreased expression of BCL2L1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2L1 protein]; Drugs, Chinese Herbal inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in decreased expression of BCL2L1 protein]; MAPK14 mutant form inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2L1 protein]; MAPK8 mutant form inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2L1 protein]; Plant Extracts inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in decreased expression of BCL2L1 protein]; pyrazolanthrone inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2L1 protein]; Resveratrol inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in decreased expression of BCL2L1 protein]
CTD PMID:19540902, PMID:19620254, PMID:19720122, PMID:27916511, PMID:30626086 NCBI chr 2:152,758,732...152,833,803
Ensembl chr 2:152,780,668...152,831,728
JBrowse link
G Bdnf brain derived neurotrophic factor decreases expression ISO Arachidonic Acid results in decreased expression of BDNF mRNA CTD PMID:16704987 NCBI chr 2:109,674,700...109,727,043
Ensembl chr 2:109,674,700...109,727,007
JBrowse link
G Bid BH3 interacting domain death agonist increases cleavage
multiple interactions
ISO Arachidonic Acid results in increased cleavage of BID protein
FADD protein promotes the reaction [Arachidonic Acid results in increased cleavage of BID protein]
CTD PMID:19720122 NCBI chr 6:120,893,119...120,917,062
Ensembl chr 6:120,891,930...120,916,853
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases degradation
ISO
EXP
Arachidonic Acid results in increased activity of CASP3 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Arachidonic Acid results in increased degradation of CASP3 protein alternative form]; [Arachidonic Acid co-treated with Iron] results in decreased expression of CASP3 protein; [Arachidonic Acid co-treated with Iron] results in increased cleavage of CASP3 protein; [Arachidonic Acid co-treated with Iron] results in increased expression of CASP3 protein modified form; Drugs, Chinese Herbal inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in increased cleavage of CASP3 protein]; FADD protein promotes the reaction [Arachidonic Acid results in increased activity of CASP3 protein]; Plant Extracts inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in increased cleavage of CASP3 protein]; Plant Extracts inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in increased expression of CASP3 protein modified form]; Resveratrol inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in decreased expression of CASP3 protein]
CTD PMID:16704987, PMID:19540902, PMID:19620254, PMID:19720122, PMID:23266427, PMID:27916511, PMID:30626086 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
ISO FADD protein promotes the reaction [Arachidonic Acid results in increased activity of CASP8 protein] CTD PMID:19720122 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503
JBrowse link
G Casp9 caspase 9 increases activity ISO Arachidonic Acid results in increased activity of CASP9 protein CTD PMID:19540902, PMID:19720122 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Cat catalase increases activity ISO Arachidonic Acid results in increased activity of CAT protein CTD PMID:7548195, PMID:16982041 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Cd40 CD40 antigen multiple interactions ISO Arachidonic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA] CTD PMID:15684433 NCBI chr 2:165,055,614...165,071,654
Ensembl chr 2:165,055,627...165,072,948
JBrowse link
G Ces1d carboxylesterase 1D decreases activity
multiple interactions
ISO Arachidonic Acid results in decreased activity of CES1 protein
[CES1 protein results in increased hydrolysis of glyceryl 2-arachidonate] which results in increased chemical synthesis of Arachidonic Acid
CTD PMID:19761868, PMID:21049984 NCBI chr 8:93,166,072...93,197,804
Ensembl chr 8:93,166,068...93,197,838
JBrowse link
G Ces2h carboxylesterase 2H multiple interactions ISO [CES2 protein results in increased hydrolysis of glyceryl 2-arachidonate] which results in increased chemical synthesis of Arachidonic Acid CTD PMID:21049984 NCBI chr 8:105,000,830...105,020,410
Ensembl chr 8:105,000,853...105,021,178
JBrowse link
G Cnr2 cannabinoid receptor 2 (macrophage) multiple interactions ISO CNR2 protein affects the reaction [Arachidonic Acid results in increased expression of CXCL8 protein] CTD PMID:15115777 NCBI chr 4:135,895,189...135,920,219
Ensembl chr 4:135,895,394...135,920,207
JBrowse link
G Col18a1 collagen, type XVIII, alpha 1 decreases expression ISO Arachidonic Acid results in decreased expression of COL18A1 mRNA CTD PMID:16704987 NCBI chr10:77,052,178...77,166,530
Ensembl chr10:77,052,178...77,166,548
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver increases expression ISO Arachidonic Acid results in increased expression of CPT1A mRNA CTD PMID:15307955 NCBI chr19:3,322,326...3,385,735
Ensembl chr19:3,322,334...3,385,733
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases phosphorylation
multiple interactions
ISO Arachidonic Acid results in increased phosphorylation of CREB1 protein
Ketoconazole inhibits the reaction [Arachidonic Acid results in increased phosphorylation of CREB1 protein]
CTD PMID:17680988 NCBI chr 1:64,532,794...64,604,548
Ensembl chr 1:64,532,645...64,604,548
JBrowse link
G Csk c-src tyrosine kinase increases activity
affects localization
ISO Arachidonic Acid results in increased activity of CSK protein
Arachidonic Acid affects the localization of CSK protein
CTD PMID:18388244 NCBI chr 9:57,626,646...57,653,631
Ensembl chr 9:57,626,646...57,653,631
JBrowse link
G Ctdspl CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like decreases expression ISO Arachidonic Acid results in decreased expression of CTDSPL mRNA CTD PMID:16704987 NCBI chr 9:118,926,536...119,044,119
Ensembl chr 9:118,926,453...119,043,998
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions
increases secretion
EXP
ISO
Arachidonic Acid promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CXCL15 mRNA]
CNR2 protein affects the reaction [Arachidonic Acid results in increased expression of CXCL8 protein]
Arachidonic Acid results in increased secretion of CXCL8 protein
CTD PMID:15115777, PMID:19063610, PMID:21457203 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cycs cytochrome c, somatic affects localization ISO Arachidonic Acid affects the localization of CYCS protein CTD PMID:19720122 NCBI chr 6:50,562,563...50,566,569
Ensembl chr 6:50,562,563...50,566,538
JBrowse link
G Cygb cytoglobin multiple interactions ISO CYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TGFB1 mRNA]; CYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TIMP1 mRNA]; CYGB protein results in decreased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid] CTD PMID:16581302 NCBI chr11:116,645,595...116,654,504
Ensembl chr11:116,645,595...116,654,313
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 affects metabolic processing
multiple interactions
ISO
EXP
CYP1A1 protein affects the metabolism of Arachidonic Acid
Arachidonic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
CTD PMID:15258110, PMID:19063610 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing
decreases activity
ISO CYP1A2 protein results in increased metabolism of Arachidonic Acid
Arachidonic Acid results in decreased activity of CYP1A2 protein
CTD PMID:12675279, PMID:16978661 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 affects metabolic processing ISO
EXP
CYP1B1 protein affects the metabolism of Arachidonic Acid CTD PMID:15258110 NCBI chr17:79,706,940...79,715,061
Ensembl chr17:79,701,537...79,715,061
JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 decreases expression EXP Arachidonic Acid results in decreased expression of CYP24A1 mRNA CTD PMID:16623957 NCBI chr 2:170,482,957...170,497,145
Ensembl chr 2:170,482,708...170,497,145
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 increases metabolic processing ISO CYP2B6 protein results in increased metabolism of Arachidonic Acid CTD PMID:12675279 NCBI chr 7:25,897,658...25,926,624
Ensembl chr 7:25,897,620...25,926,624
JBrowse link
G Cyp2c23 cytochrome P450, family 2, subfamily c, polypeptide 23 multiple interactions EXP CYP2C23 mRNA promotes the reaction [[Arachidonic Acid co-treated with VEGFA protein] results in increased phosphorylation of MAPK1 protein]; CYP2C23 mRNA promotes the reaction [[Arachidonic Acid co-treated with VEGFA protein] results in increased phosphorylation of MAPK3 protein]; CYP2C23 mRNA promotes the reaction [Arachidonic Acid results in increased phosphorylation of MAPK1 protein]; CYP2C23 mRNA promotes the reaction [Arachidonic Acid results in increased phosphorylation of MAPK3 protein] CTD PMID:19464254 NCBI chr19:44,005,022...44,029,256
Ensembl chr19:44,005,022...44,029,208
JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 increases metabolic processing ISO CYP2C8 protein results in increased metabolism of Arachidonic Acid CTD PMID:12675279 NCBI chr19:39,287,044...39,330,713
Ensembl chr19:39,269,405...39,330,713
JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 decreases activity
increases metabolic processing
multiple interactions
ISO Arachidonic Acid results in decreased activity of CYP2C19 protein
CYP2C19 protein results in increased metabolism of Arachidonic Acid
CYP2C19 gene SNP affects the susceptibility to [Adenosine Diphosphate co-treated with Arachidonic Acid]; CYP2C19 protein results in increased metabolism of [Arachidonic Acid co-treated with NADP]
CTD PMID:12675279, PMID:16978661, PMID:18004210 NCBI chr19:39,389,556...39,463,103
Ensembl chr19:39,389,556...39,463,075
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 increases metabolic processing
decreases activity
multiple interactions
ISO CYP2C9 protein results in increased metabolism of Arachidonic Acid
Arachidonic Acid results in decreased activity of CYP2C9 protein
CYP2C9 protein results in increased metabolism of [Arachidonic Acid co-treated with NADP]; Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased metabolism of Arachidonic Acid]
CTD PMID:12675279, PMID:16978661 NCBI chr19:39,061,006...39,093,948
Ensembl chr19:39,061,015...39,093,944
JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 increases metabolic processing
decreases activity
multiple interactions
ISO CYP2C9 protein results in increased metabolism of Arachidonic Acid
Arachidonic Acid results in decreased activity of CYP2C9 protein
CYP2C9 protein results in increased metabolism of [Arachidonic Acid co-treated with NADP]; Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased metabolism of Arachidonic Acid]
CTD PMID:12675279, PMID:16978661 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072
JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 increases metabolic processing ISO CYP2D6 protein results in increased metabolism of Arachidonic Acid CTD PMID:12675279 NCBI chr15:82,370,527...82,380,260
Ensembl chr15:82,370,527...82,380,260
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
affects hydroxylation
increases response to substance
decreases activity
ISO [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT18 protein; [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT8 protein; [Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein; allyl sulfide inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]]; Cadmium Chloride affects the reaction [CYP2E1 protein results in increased susceptibility to Arachidonic Acid]; CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]; CYP2E1 results in increased susceptibility to [Arachidonic Acid co-treated with Zinc Sulfate]; Ditiocarb inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]]; Zinc Sulfate inhibits the reaction [CYP2E1 results in increased susceptibility to Arachidonic Acid]
CYP2E1 protein affects the hydroxylation of Arachidonic Acid
Arachidonic Acid results in decreased activity of CYP2E1 protein
CTD PMID:12086689, PMID:12566070, PMID:15205388, PMID:16978661, PMID:17034788, PMID:21352821 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Cyp2j9 cytochrome P450, family 2, subfamily j, polypeptide 9 multiple interactions ISO Arachidonic Acid inhibits the reaction [CYP2J2 protein results in decreased methylation of Astemizole] CTD PMID:12386130 NCBI chr 4:96,568,424...96,592,523
Ensembl chr 4:96,568,429...96,591,578
JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 multiple interactions
decreases activity
increases metabolic processing
ISO Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Arachidonic Acid]
Arachidonic Acid results in decreased activity of CYP3A4 protein
CTD PMID:12675279, PMID:16978661 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964
JBrowse link
G Cyp4a31 cytochrome P450, family 4, subfamily a, polypeptide 31 increases hydroxylation ISO CYP4A11 protein results in increased hydroxylation of Arachidonic Acid CTD PMID:30259074 NCBI chr 4:115,563,627...115,579,015
Ensembl chr 4:115,563,649...115,579,015
JBrowse link
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 increases hydroxylation
multiple interactions
ISO CYP4F3 protein alternative form results in increased hydroxylation of Arachidonic Acid
rubiarbonone C inhibits the reaction [CYP4F3 protein alternative form results in increased hydroxylation of Arachidonic Acid]
CTD PMID:30259074 NCBI chr 8:71,988,482...72,009,668
Ensembl chr 8:71,988,482...72,009,626
JBrowse link
G Dct dopachrome tautomerase decreases expression EXP Arachidonic Acid results in decreased expression of DCT mRNA CTD PMID:16623957 NCBI chr14:118,012,790...118,052,246
Ensembl chr14:118,012,790...118,052,244
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO Arachidonic Acid results in increased expression of DDIT4 mRNA CTD PMID:16704987 NCBI chr10:59,949,675...59,951,770
Ensembl chr10:59,949,669...59,951,834
JBrowse link
G Ddx24 DEAD box helicase 24 decreases expression ISO Arachidonic Acid results in decreased expression of DDX24 mRNA CTD PMID:16704987 NCBI chr12:103,407,976...103,425,847
Ensembl chr12:103,407,982...103,425,830
JBrowse link
G Des desmin increases expression ISO Arachidonic Acid results in increased expression of DES mRNA CTD PMID:19089455 NCBI chr 1:75,360,292...75,368,579
Ensembl chr 1:75,360,329...75,368,579
JBrowse link
G Dhcr7 7-dehydrocholesterol reductase decreases expression ISO Arachidonic Acid results in decreased expression of DHCR7 mRNA CTD PMID:16704987 NCBI chr 7:143,823,167...143,848,410
Ensembl chr 7:143,823,145...143,848,410
JBrowse link
G Ebp phenylalkylamine Ca2+ antagonist (emopamil) binding protein decreases expression ISO Arachidonic Acid results in decreased expression of EBP mRNA CTD PMID:16704987 NCBI chr  X:8,185,329...8,193,512
Ensembl chr  X:8,185,329...8,193,512
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO 5,8,11,14-Eicosatetraynoic Acid inhibits the reaction [Arachidonic Acid results in increased phosphorylation of and results in increased activity of EGFR protein] CTD PMID:15525798 NCBI chr11:16,752,203...16,913,907
Ensembl chr11:16,752,203...16,918,158
JBrowse link
G Egr1 early growth response 1 increases expression ISO
EXP
Arachidonic Acid results in increased expression of EGR1 mRNA CTD PMID:8764118, PMID:16704987 NCBI chr18:34,861,207...34,864,956
Ensembl chr18:34,859,823...34,864,984
JBrowse link
G Eif4ebp3 eukaryotic translation initiation factor 4E binding protein 3 multiple interactions ISO Arachidonic Acid promotes the reaction [Quercetin results in decreased phosphorylation of EIF4EBP3 protein] CTD PMID:20551291 NCBI chr18:36,664,060...36,666,324
Ensembl chr18:36,664,060...36,665,917
JBrowse link
G Ephx2 epoxide hydrolase 2, cytoplasmic increases metabolic processing EXP EPHX2 protein results in increased metabolism of Arachidonic Acid CTD PMID:26165641 NCBI chr14:66,084,372...66,124,522
Ensembl chr14:66,084,374...66,124,500
JBrowse link
G Erg28 ergosterol biosynthesis 28 decreases expression ISO Arachidonic Acid results in decreased expression of ERG28 mRNA CTD PMID:16704987 NCBI chr12:85,815,447...85,824,893
Ensembl chr12:85,815,448...85,824,550
JBrowse link
G F3 coagulation factor III increases expression ISO Arachidonic Acid results in increased expression of F3 protein CTD PMID:27556861 NCBI chr 3:121,723,537...121,735,052
Ensembl chr 3:121,723,537...121,735,048
JBrowse link
G Faah fatty acid amide hydrolase increases chemical synthesis
multiple interactions
ISO FAAH protein results in increased chemical synthesis of Arachidonic Acid
Nitroglycerin promotes the reaction [FAAH protein results in increased chemical synthesis of Arachidonic Acid]
CTD PMID:19515121 NCBI chr 4:115,996,668...116,018,837
Ensembl chr 4:115,967,145...116,017,926
JBrowse link
G Fadd Fas (TNFRSF6)-associated via death domain multiple interactions ISO FADD protein promotes the reaction [Arachidonic Acid results in increased activity of CASP3 protein]; FADD protein promotes the reaction [Arachidonic Acid results in increased activity of CASP8 protein]; FADD protein promotes the reaction [Arachidonic Acid results in increased cleavage of BID protein] CTD PMID:19720122 NCBI chr 7:144,578,323...144,582,441
Ensembl chr 7:144,577,318...144,582,463
JBrowse link
G Fads1 fatty acid desaturase 1 multiple interactions ISO [geraniol results in decreased activity of FADS1 protein] which results in decreased chemical synthesis of Arachidonic Acid CTD PMID:16462894 NCBI chr19:10,182,877...10,196,874
Ensembl chr19:10,182,888...10,196,877
JBrowse link
G Fads2 fatty acid desaturase 2 decreases expression ISO Arachidonic Acid results in decreased expression of FADS2 mRNA CTD PMID:21457203 NCBI chr19:10,062,765...10,101,503
Ensembl chr19:10,062,765...10,101,746
JBrowse link
G Fas Fas (TNF receptor superfamily member 6) multiple interactions
increases expression
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Arachidonic Acid results in increased expression of FAS protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Arachidonic Acid results in increased expression of FAS protein]; Acetylcysteine inhibits the reaction [Arachidonic Acid results in increased expression of FAS protein]; FOS protein affects the reaction [MAP2K1 protein inhibits the reaction [Arachidonic Acid results in increased expression of FAS protein]]; JUN protein affects the reaction [Arachidonic Acid results in increased expression of FAS protein]; MAP2K1 protein inhibits the reaction [Arachidonic Acid results in increased expression of FAS protein]
Arachidonic Acid results in increased expression of FAS mRNA; Arachidonic Acid results in increased expression of FAS protein
CTD PMID:19720122 NCBI chr19:34,290,647...34,327,775
Ensembl chr19:34,290,666...34,327,772
JBrowse link
G Fasl Fas ligand (TNF superfamily, member 6) multiple interactions
increases expression
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Arachidonic Acid results in increased expression of FASLG protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Arachidonic Acid results in increased expression of FASLG protein]; Acetylcysteine inhibits the reaction [Arachidonic Acid results in increased expression of FASLG protein]; FOS protein affects the reaction [MAP2K1 protein inhibits the reaction [Arachidonic Acid results in increased expression of FASLG protein]]; JUN protein affects the reaction [Arachidonic Acid results in increased expression of FASLG protein]; MAP2K1 protein inhibits the reaction [Arachidonic Acid results in increased expression of FASLG protein]
Arachidonic Acid results in increased expression of FASLG mRNA; Arachidonic Acid results in increased expression of FASLG protein
CTD PMID:19720122 NCBI chr 1:161,780,691...161,788,495
Ensembl chr 1:161,780,689...161,788,495
JBrowse link
G Fasn fatty acid synthase decreases expression EXP Arachidonic Acid results in decreased expression of FASN mRNA CTD PMID:19159447 NCBI chr11:120,805,958...120,825,166
Ensembl chr11:120,805,846...120,824,547
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 decreases expression ISO Arachidonic Acid results in decreased expression of FGFR3 mRNA CTD PMID:16704987 NCBI chr 5:33,721,724...33,737,068
Ensembl chr 5:33,721,674...33,737,068
JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions
increases expression
decreases phosphorylation
ISO
EXP
[Arachidonic Acid co-treated with Quercetin co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in decreased expression of FOS protein; Arachidonic Acid inhibits the reaction [Quercetin results in increased expression of FOS protein]; Flurbiprofen inhibits the reaction [Arachidonic Acid results in increased expression of FOS mRNA]; FOS protein affects the reaction [MAP2K1 protein inhibits the reaction [Arachidonic Acid results in increased expression of FAS protein]]; FOS protein affects the reaction [MAP2K1 protein inhibits the reaction [Arachidonic Acid results in increased expression of FASLG protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Arachidonic Acid results in increased expression of FOS mRNA]
Arachidonic Acid results in decreased phosphorylation of FOS protein
CTD PMID:8764118, PMID:10864209, PMID:15878913, PMID:16704987, PMID:19720122, PMID:20551291 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Fosl1 fos-like antigen 1 increases expression ISO Arachidonic Acid results in increased expression of FOSL1 mRNA CTD PMID:16704987 NCBI chr19:5,447,698...5,455,938
Ensembl chr19:5,447,547...5,455,946
JBrowse link
G Gap43 growth associated protein 43 increases phosphorylation EXP Arachidonic Acid results in increased phosphorylation of GAP43 protein CTD PMID:9852580 NCBI chr16:42,248,552...42,340,651
Ensembl chr16:42,248,442...42,340,651
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
increases activity
ISO Arachidonic Acid results in increased expression of GCLC mRNA
Arachidonic Acid results in increased activity of GCLC protein
CTD PMID:16704987, PMID:17092368 NCBI chr 9:77,754,535...77,794,489
Ensembl chr 9:77,754,535...77,794,485
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression ISO Arachidonic Acid results in increased expression of GCLM mRNA CTD PMID:16704987 NCBI chr 3:122,245,487...122,267,215
Ensembl chr 3:122,245,557...122,270,732
JBrowse link
G Glrx glutaredoxin affects response to substance EXP GLRX protein affects the susceptibility to Arachidonic Acid CTD PMID:19373248 NCBI chr13:75,839,885...75,850,151
Ensembl chr13:75,839,868...75,850,154
JBrowse link
G Gnpda1 glucosamine-6-phosphate deaminase 1 decreases expression ISO Arachidonic Acid results in decreased expression of GNPDA1 mRNA CTD PMID:16704987 NCBI chr18:38,327,537...38,338,993
Ensembl chr18:38,327,535...38,339,003
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions EXP Drugs, Chinese Herbal inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in increased expression of ALT protein]; Plant Extracts inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in increased expression of ALT protein] CTD PMID:27916511 NCBI chr15:76,696,726...76,699,675
Ensembl chr15:76,695,716...76,699,686
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO [Iodoacetates results in decreased activity of GPX1 protein] which affects the metabolism of Arachidonic Acid CTD PMID:11115402 NCBI chr 9:108,339,080...108,340,342
Ensembl chr 9:108,338,903...108,340,343
JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO [Iodoacetates results in decreased activity of GPX4 protein] which affects the metabolism of Arachidonic Acid; Arachidonic Acid promotes the reaction [Sodium Selenite results in increased expression of and results in increased activity of GPX4 protein] CTD PMID:11115402, PMID:14642406 NCBI chr10:80,047,166...80,056,439
Ensembl chr10:80,047,166...80,056,439
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO [SB 216763 results in decreased activity of GSK3B protein] results in decreased susceptibility to [Arachidonic Acid co-treated with Iron] CTD PMID:19620254 NCBI chr16:38,089,001...38,246,084
Ensembl chr16:38,089,001...38,246,084
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase decreases expression ISO Arachidonic Acid results in decreased expression of HMGCR mRNA CTD PMID:16704987 NCBI chr13:96,648,962...96,670,936
Ensembl chr13:96,648,967...96,670,936
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
decreases response to substance
ISO Arachidonic Acid results in increased expression of HMOX1 mRNA
HMOX1 protein results in decreased susceptibility to Arachidonic Acid
CTD PMID:15036350, PMID:16704987, PMID:17092368 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hs2st1 heparan sulfate 2-O-sulfotransferase 1 decreases expression ISO Arachidonic Acid results in decreased expression of HS2ST1 mRNA CTD PMID:16704987 NCBI chr 3:144,429,701...144,570,216
Ensembl chr 3:144,429,706...144,570,181
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 decreases expression EXP Arachidonic Acid results in decreased expression of HSP90AB1 mRNA CTD PMID:16623957 NCBI chr17:45,567,778...45,573,261
Ensembl chr17:45,567,775...45,573,271
JBrowse link
G Hspb11 heat shock protein family B (small), member 11 decreases expression ISO Arachidonic Acid results in decreased expression of HSPB11 mRNA CTD PMID:16704987 NCBI chr 4:107,253,593...107,284,497
Ensembl chr 4:107,253,593...107,279,938
JBrowse link
G Htr1a 5-hydroxytryptamine (serotonin) receptor 1A multiple interactions ISO Arachidonic Acid metabolite inhibits the reaction [HTR1A protein inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]] CTD PMID:11356925 NCBI chr13:105,443,693...105,448,133
Ensembl chr13:105,443,639...105,448,122
JBrowse link
G Id3 inhibitor of DNA binding 3 decreases expression ISO Arachidonic Acid results in decreased expression of ID3 mRNA CTD PMID:16704987 NCBI chr 4:136,143,822...136,145,392
Ensembl chr 4:136,143,497...136,145,755
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase decreases expression ISO Arachidonic Acid results in decreased expression of IDI1 mRNA CTD PMID:16704987 NCBI chr13:8,885,606...8,892,396
Ensembl chr13:8,885,501...8,892,451
JBrowse link
G Igfbp7 insulin-like growth factor binding protein 7 decreases expression ISO Arachidonic Acid results in decreased expression of IGFBP7 mRNA CTD PMID:16704987 NCBI chr 5:77,349,240...77,408,045
Ensembl chr 5:77,349,240...77,408,041
JBrowse link
G Il12b interleukin 12b multiple interactions ISO Arachidonic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA] CTD PMID:15684433 NCBI chr11:44,400,063...44,414,677
Ensembl chr11:44,400,063...44,414,033
JBrowse link
G Il1a interleukin 1 alpha multiple interactions EXP [IL1A protein co-treated with Arachidonic Acid] results in increased abundance of Dinoprostone CTD PMID:11351503 NCBI chr 2:129,299,609...129,310,186
Ensembl chr 2:129,299,610...129,309,972
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Arachidonic Acid results in increased abundance of Dinoprostone] promotes the reaction [IL1B protein results in increased expression of PTGS2 protein] CTD PMID:11112151 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il4 interleukin 4 multiple interactions ISO [IL4 protein co-treated with Arachidonic Acid] results in increased activity of ALOX15 protein; [IL4 protein co-treated with Arachidonic Acid] results in increased expression of ALOX15 mRNA CTD PMID:11861792 NCBI chr11:53,612,460...53,618,665
Ensembl chr11:53,602,982...53,618,669
JBrowse link
G Il6 interleukin 6 increases secretion ISO Arachidonic Acid results in increased secretion of IL6 protein CTD PMID:20436887, PMID:21457203 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Ilvbl ilvB (bacterial acetolactate synthase)-like decreases expression ISO Arachidonic Acid results in decreased expression of ILVBL mRNA CTD PMID:16704987 NCBI chr10:78,574,344...78,584,502
Ensembl chr10:78,574,346...78,584,502
JBrowse link
G Ins2 insulin II increases secretion
multiple interactions
ISO Arachidonic Acid results in increased secretion of INS protein
Arachidonic Acid promotes the reaction [Glucose results in increased secretion of INS protein]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide promotes the reaction [Arachidonic Acid results in increased secretion of INS protein]; phenidone promotes the reaction [Arachidonic Acid results in increased secretion of INS protein]
CTD PMID:17192482 NCBI chr 7:142,678,656...142,679,726
Ensembl chr 7:142,678,656...142,743,381
JBrowse link
G Isl1 ISL1 transcription factor, LIM/homeodomain decreases expression ISO Arachidonic Acid results in decreased expression of ISL1 mRNA CTD PMID:16704987 NCBI chr13:116,298,270...116,309,688
Ensembl chr13:116,298,281...116,309,689
JBrowse link
G Itga2b integrin alpha 2b increases expression
multiple interactions
ISO Arachidonic Acid results in increased expression of ITGA2B protein
Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGA2B protein]; Glucose inhibits the reaction [Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGA2B protein]]
CTD PMID:18413191 NCBI chr11:102,453,297...102,469,883
Ensembl chr11:102,453,297...102,470,122
JBrowse link
G Itga6 integrin alpha 6 increases expression ISO Arachidonic Acid results in increased expression of ITGA6 mRNA CTD PMID:16704987 NCBI chr 2:71,786,886...71,858,427
Ensembl chr 2:71,745,616...71,858,416
JBrowse link
G Itgb3 integrin beta 3 multiple interactions
increases expression
ISO Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGB3 protein]; Glucose inhibits the reaction [Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGB3 protein]]; Quercetin inhibits the reaction [Arachidonic Acid results in increased expression of ITGB3 protein] CTD PMID:18413191, PMID:23249183 NCBI chr11:104,608,000...104,670,476
Ensembl chr11:104,608,000...104,670,476
JBrowse link
G Jun jun proto-oncogene multiple interactions
increases expression
ISO
EXP
Arachidonic Acid results in increased expression of and results in increased phosphorylation of JUN protein; JUN protein affects the reaction [Arachidonic Acid results in increased expression of FAS protein]; JUN protein affects the reaction [Arachidonic Acid results in increased expression of FASLG protein]
Arachidonic Acid results in increased expression of JUN mRNA
CTD PMID:8764118, PMID:16704987, PMID:19720122 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222
JBrowse link
G Junb jun B proto-oncogene multiple interactions
increases expression
EXP 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Arachidonic Acid analog results in increased expression of JUNB mRNA]
Arachidonic Acid results in increased expression of JUNB mRNA
CTD PMID:8764118 NCBI chr 8:84,976,909...84,978,748
Ensembl chr 8:84,974,484...84,978,718
Ensembl chr 8:84,974,484...84,978,718
JBrowse link
G Kcnk10 potassium channel, subfamily K, member 10 multiple interactions ISO Arachidonic Acid promotes the reaction [KCNK10 protein results in increased transport of Potassium] CTD PMID:16075240 NCBI chr12:98,429,432...98,578,213
Ensembl chr12:98,429,437...98,578,310
JBrowse link
G Kcnk2 potassium channel, subfamily K, member 2 multiple interactions ISO Arachidonic Acid promotes the reaction [KCNK2 protein results in increased transport of Potassium] CTD PMID:16075240 NCBI chr 1:189,207,930...189,402,782
Ensembl chr 1:189,207,930...189,402,273
JBrowse link
G Kcnk4 potassium channel, subfamily K, member 4 multiple interactions ISO Arachidonic Acid promotes the reaction [KCNK4 protein results in increased transport of Potassium] CTD PMID:10767409, PMID:16075240 NCBI chr19:6,925,662...6,934,883
Ensembl chr19:6,923,966...6,934,515
JBrowse link
G Klf5 Kruppel-like factor 5 increases expression ISO Arachidonic Acid results in increased expression of KLF5 mRNA CTD PMID:16704987 NCBI chr14:99,298,691...99,313,412
Ensembl chr14:99,298,691...99,315,036
JBrowse link
G Kng2 kininogen 2 multiple interactions ISO Arachidonic Acid inhibits the reaction [GW 4064 results in increased expression of KNG1 mRNA] CTD PMID:15307955 NCBI chr16:22,985,852...23,029,101
Ensembl chr16:22,985,854...23,029,482
JBrowse link
G Krt18 keratin 18 multiple interactions ISO [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT18 protein CTD PMID:17034788 NCBI chr15:102,028,216...102,032,026
Ensembl chr15:102,028,180...102,032,027
JBrowse link
G Krt8 keratin 8 multiple interactions ISO [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT8 protein CTD PMID:17034788 NCBI chr15:101,996,711...102,004,342
Ensembl chr15:101,996,698...102,004,482
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 decreases expression EXP Arachidonic Acid results in decreased expression of LAMP2 mRNA CTD PMID:16623957 NCBI chr  X:38,399,647...38,456,460
Ensembl chr  X:38,401,357...38,456,454
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions
decreases response to substance
ISO
EXP
Aspirin inhibits the reaction [LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]; dazoxiben inhibits the reaction [LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]; LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]; tempol inhibits the reaction [LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]
LDLR gene mutant form results in decreased susceptibility to Arachidonic Acid
Aspirin inhibits the reaction [LDLR gene mutant form results in decreased susceptibility to Arachidonic Acid]; dazoxiben inhibits the reaction [LDLR gene mutant form results in decreased susceptibility to Arachidonic Acid]; Indomethacin promotes the reaction [LDLR gene mutant form results in decreased susceptibility to Arachidonic Acid]
CTD PMID:20530721 NCBI chr 9:21,723,576...21,749,919
Ensembl chr 9:21,723,483...21,749,919
JBrowse link
G Lep leptin multiple interactions EXP Arachidonic Acid promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of LEP mRNA] CTD PMID:19063610 NCBI chr 6:29,060,221...29,073,876
Ensembl chr 6:29,060,220...29,073,877
JBrowse link
G Lipc lipase, hepatic decreases abundance
multiple interactions
EXP LIPC gene mutant form results in decreased abundance of Arachidonic Acid
[LIPC gene mutant form co-treated with LIPG gene mutant form] results in decreased abundance of Arachidonic Acid
CTD PMID:24777581 NCBI chr 9:70,798,128...70,952,221
Ensembl chr 9:70,798,128...70,952,226
JBrowse link
G Lipg lipase, endothelial decreases abundance
multiple interactions
EXP LIPG gene mutant form results in decreased abundance of Arachidonic Acid
[LIPC gene mutant form co-treated with LIPG gene mutant form] results in decreased abundance of Arachidonic Acid
CTD PMID:24777581 NCBI chr18:74,939,322...74,961,263
Ensembl chr18:74,939,322...74,961,263
JBrowse link
G Lrat lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase) increases expression ISO Arachidonic Acid results in increased expression of LRAT mRNA CTD PMID:12576510 NCBI chr 3:82,892,582...82,903,974
Ensembl chr 3:82,892,579...82,903,973
JBrowse link
G Lss lanosterol synthase decreases expression ISO Arachidonic Acid results in decreased expression of LSS mRNA CTD PMID:16704987 NCBI chr10:76,531,565...76,557,139
Ensembl chr10:76,531,588...76,557,138
JBrowse link
G Ltb4r1 leukotriene B4 receptor 1 affects response to substance EXP LTB4R1 protein affects the susceptibility to Arachidonic Acid CTD PMID:10934231 NCBI chr14:55,765,962...55,768,492
Ensembl chr14:55,765,962...55,768,494
JBrowse link
G Luc7l3 LUC7-like 3 (S. cerevisiae) decreases expression ISO Arachidonic Acid results in decreased expression of LUC7L3 mRNA CTD PMID:16704987 NCBI chr11:94,291,073...94,322,329
Ensembl chr11:94,287,890...94,321,988
JBrowse link
G Maff v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) increases expression ISO Arachidonic Acid results in increased expression of MAFF mRNA CTD PMID:16704987 NCBI chr15:79,346,621...79,359,078
Ensembl chr15:79,346,621...79,359,076
JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 multiple interactions ISO FOS protein affects the reaction [MAP2K1 protein inhibits the reaction [Arachidonic Acid results in increased expression of FAS protein]]; FOS protein affects the reaction [MAP2K1 protein inhibits the reaction [Arachidonic Acid results in increased expression of FASLG protein]]; MAP2K1 protein inhibits the reaction [Arachidonic Acid results in increased expression of FAS protein]; MAP2K1 protein inhibits the reaction [Arachidonic Acid results in increased expression of FASLG protein] CTD PMID:19720122 NCBI chr 9:64,185,769...64,253,605
Ensembl chr 9:64,185,770...64,253,631
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases phosphorylation
affects abundance
multiple interactions
EXP
ISO
Arachidonic Acid results in increased phosphorylation of MAPK1 protein
MAPK1 protein affects the abundance of Arachidonic Acid
[Arachidonic Acid co-treated with VEGFA protein] results in increased phosphorylation of MAPK1 protein; CYP2C23 mRNA promotes the reaction [[Arachidonic Acid co-treated with VEGFA protein] results in increased phosphorylation of MAPK1 protein]; CYP2C23 mRNA promotes the reaction [Arachidonic Acid results in increased phosphorylation of MAPK1 protein]
CTD PMID:16216387, PMID:19464254 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk14 mitogen-activated protein kinase 14 multiple interactions ISO MAPK14 mutant form inhibits the reaction [Arachidonic Acid affects the localization of BAX protein]; MAPK14 mutant form inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2 protein]; MAPK14 mutant form inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2L1 protein]
MAPK14 protein promotes the reaction [2,2',4,6-tetrachlorobiphenyl results in increased secretion of Arachidonic Acid]
CTD PMID:16120751, PMID:19540902 NCBI chr17:28,691,342...28,748,405
Ensembl chr17:28,691,329...28,748,406
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
affects abundance
increases phosphorylation
EXP
ISO
[Arachidonic Acid co-treated with VEGFA protein] results in increased phosphorylation of MAPK3 protein; CYP2C23 mRNA promotes the reaction [[Arachidonic Acid co-treated with VEGFA protein] results in increased phosphorylation of MAPK3 protein]; CYP2C23 mRNA promotes the reaction [Arachidonic Acid results in increased phosphorylation of MAPK3 protein]
MAPK3 protein affects the abundance of Arachidonic Acid
CTD PMID:16216387, PMID:19464254 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO MAPK8 mutant form inhibits the reaction [Arachidonic Acid affects the localization of BAX protein]; MAPK8 mutant form inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2 protein]; MAPK8 mutant form inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2L1 protein] CTD PMID:19540902 NCBI chr14:33,377,898...33,447,353
Ensembl chr14:33,377,898...33,447,158
JBrowse link
G Mapt microtubule-associated protein tau increases phosphorylation
multiple interactions
ISO Arachidonic Acid results in increased phosphorylation of MAPT protein
Ro 31-8220 inhibits the reaction [Arachidonic Acid results in increased phosphorylation of MAPT protein]
CTD PMID:12605413 NCBI chr11:104,229,409...104,332,090
Ensembl chr11:104,231,390...104,332,090
JBrowse link
G Mmp13 matrix metallopeptidase 13 increases secretion
multiple interactions
increases expression
ISO Arachidonic Acid results in increased secretion of MMP13 protein
Isotretinoin inhibits the reaction [Arachidonic Acid results in increased expression of MMP13 mRNA]; Isotretinoin inhibits the reaction [Arachidonic Acid results in increased secretion of MMP13 protein]
CTD PMID:16185265 NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
increases expression
increases secretion
ISO Isotretinoin inhibits the reaction [Arachidonic Acid results in increased expression of MMP2 mRNA]; Isotretinoin inhibits the reaction [Arachidonic Acid results in increased secretion of MMP2 protein] CTD PMID:16185265 NCBI chr 8:92,827,290...92,853,421
Ensembl chr 8:92,827,291...92,853,420
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
multiple interactions
increases secretion
ISO Arachidonic Acid results in increased expression of MMP9 mRNA
Isotretinoin inhibits the reaction [Arachidonic Acid results in increased expression of MMP9 mRNA]; Isotretinoin inhibits the reaction [Arachidonic Acid results in increased secretion of MMP9 protein]
CTD PMID:16185265 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850
JBrowse link
G Mpo myeloperoxidase increases secretion
multiple interactions
increases expression
ISO
EXP
Arachidonic Acid results in increased secretion of MPO protein
5-((1,5-bis(4-methoxyphenyl)pyrazol-3-yl)dimethoxymethyl)-2-chlorobenzamide inhibits the reaction [Arachidonic Acid results in increased expression of MPO protein]
CTD PMID:3111576, PMID:9831321 NCBI chr11:87,793,784...87,804,412
Ensembl chr11:87,793,581...87,804,413
JBrowse link
G Mt2 metallothionein 2 multiple interactions ISO Arachidonic Acid promotes the reaction [Zinc Sulfate results in increased expression of MT2A mRNA] CTD PMID:12566070 NCBI chr 8:94,172,618...94,173,567
Ensembl chr 8:94,172,664...94,173,568
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO [Quercetin co-treated with Arachidonic Acid] results in decreased phosphorylation of MTOR protein CTD PMID:20551291 NCBI chr 4:148,448,582...148,557,685
Ensembl chr 4:148,448,611...148,557,683
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions
increases localization
ISO Adiponectin inhibits the reaction [Arachidonic Acid results in increased localization of NCF1 protein]; Arachidonic Acid affects the reaction [Zymosan analog affects the localization of NCF1 protein] CTD PMID:12101222, PMID:20832062 NCBI chr 5:134,220,053...134,229,628
Ensembl chr 5:134,220,053...134,229,625
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 multiple interactions ISO Arachidonic Acid affects the reaction [Zymosan analog affects the localization of NCF2 protein] CTD PMID:12101222 NCBI chr 1:152,800,153...152,836,990
Ensembl chr 1:152,800,194...152,836,991
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions ISO Arachidonic Acid results in increased cleavage of and results in increased secretion of NOX1 protein; Cholesterol, LDL affects the reaction [Adiponectin inhibits the reaction [Arachidonic Acid results in increased cleavage of NOX1 protein]] CTD PMID:20832062 NCBI chr  X:134,086,421...134,137,711
Ensembl chr  X:134,086,421...134,221,956
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 affects binding
multiple interactions
ISO Arachidonic Acid binds to NR1H4 protein
Arachidonic Acid inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]
CTD PMID:15307955 NCBI chr10:89,454,234...89,533,645
Ensembl chr10:89,454,234...89,533,585
JBrowse link
G Nr2f1 nuclear receptor subfamily 2, group F, member 1 decreases expression ISO Arachidonic Acid results in decreased expression of NR2F1 mRNA CTD PMID:16704987 NCBI chr13:78,188,971...78,198,873
Ensembl chr13:78,188,973...78,199,757
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 decreases expression ISO Arachidonic Acid results in decreased expression of NR4A2 mRNA CTD PMID:16704987 NCBI chr 2:57,106,830...57,124,003
Ensembl chr 2:57,106,830...57,124,003
JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 multiple interactions
decreases chemical synthesis
EXP [NR5A2 gene mutant form results in increased susceptibility to Dietary Fats] which results in decreased abundance of Arachidonic Acid analog
NR5A2 gene mutant form results in decreased chemical synthesis of Arachidonic Acid
CTD PMID:29515023 NCBI chr 1:136,842,562...136,960,448
Ensembl chr 1:136,842,571...136,960,448
JBrowse link
G Nrtn neurturin decreases expression ISO Arachidonic Acid results in decreased expression of NRTN mRNA CTD PMID:16704987 NCBI chr17:56,751,323...56,757,548
Ensembl chr17:56,751,325...56,757,530
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions
increases cleavage
ISO
EXP
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Arachidonic Acid results in increased cleavage of PARP1 protein]; [Arachidonic Acid co-treated with Iron] results in increased expression of PARP1 protein modified form; Plant Extracts inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in increased expression of PARP1 protein modified form] CTD PMID:10403056, PMID:19540902, PMID:21132278, PMID:30626086 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Pde4dip phosphodiesterase 4D interacting protein (myomegalin) decreases expression ISO Arachidonic Acid results in decreased expression of PDE4DIP mRNA CTD PMID:16704987 NCBI chr 3:97,689,828...97,888,707
Ensembl chr 3:97,689,824...97,888,707
JBrowse link
G Pdss2 prenyl (solanesyl) diphosphate synthase, subunit 2 decreases expression ISO Arachidonic Acid results in decreased expression of PDSS2 mRNA CTD PMID:16704987 NCBI chr10:43,218,248...43,464,882
Ensembl chr10:43,221,486...43,464,882
JBrowse link
G Phlda1 pleckstrin homology like domain, family A, member 1 increases expression ISO Arachidonic Acid results in increased expression of PHLDA1 mRNA CTD PMID:16704987 NCBI chr10:111,506,286...111,508,649
Ensembl chr10:111,506,286...111,508,645
JBrowse link
G Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) multiple interactions
increases expression
ISO AHR affects the reaction [Tetrachlorodibenzodioxin promotes the reaction [PLA2G4A protein results in increased secretion of Arachidonic Acid]]; Dinoprostone promotes the reaction [Arachidonic Acid results in increased expression of PLA2G4A mRNA]; Flurbiprofen inhibits the reaction [Arachidonic Acid results in increased expression of PLA2G4A mRNA]
PLA2G4A protein promotes the reaction [2,2',4,6-tetrachlorobiphenyl results in increased secretion of Arachidonic Acid]
Arachidonic Acid results in increased expression of PLA2G4A mRNA; Arachidonic Acid results in increased expression of PLA2G4A protein
CTD PMID:15878913, PMID:16120751, PMID:19162293 NCBI chr 1:149,829,618...149,961,290
Ensembl chr 1:149,829,618...149,961,290
JBrowse link
G Pla2g5 phospholipase A2, group V multiple interactions ISO PLA2G5 protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Arachidonic Acid] CTD PMID:9495842 NCBI chr 4:138,799,247...138,863,562
Ensembl chr 4:138,799,244...138,863,482
JBrowse link
G Pla2g6 phospholipase A2, group VI multiple interactions ISO PLA2G6 protein promotes the reaction [2,2',4,6-tetrachlorobiphenyl results in increased secretion of Arachidonic Acid] CTD PMID:16120751 NCBI chr15:79,286,228...79,328,385
Ensembl chr15:79,286,228...79,328,390
JBrowse link
G Plaa phospholipase A2, activating protein multiple interactions EXP PLAA protein promotes the reaction [Lipopolysaccharides results in increased abundance of Arachidonic Acid] CTD PMID:11094054 NCBI chr 4:94,565,139...94,603,247
Ensembl chr 4:94,567,514...94,603,244
JBrowse link
G Plin2 perilipin 2 increases expression EXP
ISO
Arachidonic Acid results in increased expression of PLIN2 mRNA
Arachidonic Acid results in increased expression of PLIN2 mRNA; Arachidonic Acid results in increased expression of PLIN2 protein
CTD PMID:16489205 NCBI chr 4:86,626,910...86,670,217
Ensembl chr 4:86,648,386...86,670,060
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO Arachidonic Acid results in increased expression of PMAIP1 mRNA CTD PMID:16704987 NCBI chr18:66,458,604...66,465,558
Ensembl chr18:66,458,533...66,465,565
JBrowse link
G Pon1 paraoxonase 1 multiple interactions
decreases activity
ISO Arachidonic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; Arachidonic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid]
Arachidonic Acid results in decreased activity of PON1 protein
CTD PMID:15375178 NCBI chr 6:5,168,090...5,193,987
Ensembl chr 6:5,168,090...5,193,946
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression
multiple interactions
ISO Arachidonic Acid results in increased expression of PPARA mRNA; Arachidonic Acid results in increased expression of PPARA protein
Arachidonic Acid binds to and results in increased activity of PPARA protein
CTD PMID:10403814, PMID:11172467, PMID:15491415 NCBI chr15:85,734,910...85,806,851
Ensembl chr15:85,734,983...85,802,819
JBrowse link
G Ppard peroxisome proliferator activator receptor delta increases expression ISO Arachidonic Acid results in increased expression of PPARD mRNA CTD PMID:11172467 NCBI chr17:28,232,754...28,301,469
Ensembl chr17:28,232,700...28,301,474
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma decreases expression
increases expression
multiple interactions
ISO
EXP
Arachidonic Acid results in decreased expression of PPARG mRNA; Arachidonic Acid results in decreased expression of PPARG protein
Arachidonic Acid results in increased expression of PPARG protein
Arachidonic Acid promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of PPARG mRNA]
CTD PMID:11172467, PMID:12604186, PMID:19063610 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha decreases expression EXP Arachidonic Acid results in decreased expression of PPP1CA mRNA CTD PMID:16623957 NCBI chr19:4,192,174...4,195,419
Ensembl chr19:4,192,065...4,195,420
JBrowse link
G Prpf4 pre-mRNA processing factor 4 decreases expression ISO Arachidonic Acid results in decreased expression of PRPF4 mRNA CTD PMID:16704987 NCBI chr 4:62,408,762...62,426,990
Ensembl chr 4:62,408,797...62,426,990
JBrowse link
G Psat1 phosphoserine aminotransferase 1 increases expression ISO Arachidonic Acid results in increased expression of PSAT1 mRNA CTD PMID:16704987 NCBI chr19:15,905,123...15,925,059
Ensembl chr19:15,904,678...15,947,337
JBrowse link
G Ptafr platelet-activating factor receptor multiple interactions ISO [Docosahexaenoic Acids co-treated with Arachidonic Acid] affects the expression of PTAFR mRNA; Arachidonic Acid inhibits the reaction [1-O-hexadecyl-2-N-methylcarbamylphosphatidylcholine results in increased expression of PTAFR mRNA] CTD PMID:17515866 NCBI chr 4:132,564,067...132,582,683
Ensembl chr 4:132,564,067...132,582,683
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases activity
increases response to substance
increases metabolic processing
multiple interactions
ISO
EXP
Arachidonic Acid results in increased activity of PTGS1 protein
PTGS1 results in increased susceptibility to Arachidonic Acid
PTGS1 protein alternative form results in increased metabolism of Arachidonic Acid; PTGS1 protein results in increased metabolism of Arachidonic Acid
[[Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to 3,4-Methylenedioxyamphetamine] which results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine; [[Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to Methamphetamine] which results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine; [Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to 3,4-Methylenedioxyamphetamine; [Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to Methamphetamine; [PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of 12-hydroxy-5,8,10-heptadecatrienoic acid; [PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of Thromboxane B2; arzanol inhibits the reaction [[PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of 12-hydroxy-5,8,10-heptadecatrienoic acid]; arzanol inhibits the reaction [[PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of Thromboxane B2]; Aspirin inhibits the reaction [[Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to Methamphetamine]; Aspirin inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein]; DuP 697 inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein]; Resveratrol inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein]; SC 560 inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein]; valerylsalicylate inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein]
CTD PMID:15863457, PMID:16141368, PMID:19751497, PMID:20933508, PMID:21163909 NCBI chr 2:36,216,742...36,258,593
Ensembl chr 2:36,230,426...36,252,272
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
increases metabolic processing
increases response to substance
increases activity
ISO
EXP
[[Arachidonic Acid results in increased activity of PTGS2 protein] which results in increased susceptibility to 3,4-Methylenedioxyamphetamine] which results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine; [[Arachidonic Acid results in increased activity of PTGS2 protein] which results in increased susceptibility to Methamphetamine] which results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine; [ajulemic acid results in increased expression of PTGS2 mRNA] which results in increased secretion of Arachidonic Acid; [Arachidonic Acid results in increased abundance of Dinoprostone] promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]; [Arachidonic Acid results in increased activity of PTGS2 protein] which results in increased susceptibility to 3,4-Methylenedioxyamphetamine; [Arachidonic Acid results in increased activity of PTGS2 protein] which results in increased susceptibility to Methamphetamine; [PTGS2 co-treated with Arachidonic Acid] results in increased expression of VEGFA; Arachidonic Acid inhibits the reaction [5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulfonyl)phenyl-2(5H)-furanone binds to and results in decreased activity of PTGS2 protein]; Arachidonic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Aspirin inhibits the reaction [[Arachidonic Acid results in increased activity of PTGS2 protein] which results in increased susceptibility to Methamphetamine]; Aspirin inhibits the reaction [Arachidonic Acid results in increased activity of PTGS2 protein]; Dinoprostone promotes the reaction [Arachidonic Acid results in increased expression of PTGS2 mRNA]; Flurbiprofen inhibits the reaction [Arachidonic Acid results in increased expression of PTGS2 mRNA]; Ibuprofen inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]; nimesulide inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]
Arachidonic Acid results in increased expression of PTGS2 protein
PTGS2 results in increased susceptibility to Arachidonic Acid
12-HPETE inhibits the reaction [Sodium Salicylate inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]]; 2-methoxybenzoic acid inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]; [Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] which results in increased metabolism of Arachidonic Acid; [nimesulide results in decreased expression of PTGS2] which results in increased abundance of Arachidonic Acid; [PTGS2 protein results in increased abundance of prostaglandin G2] inhibits the reaction [Sodium Salicylate inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]]; Arachidonic Acid affects the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]; Benzoic Acid inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]; Eugenol inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] which results in increased metabolism of Arachidonic Acid]; Sodium Salicylate inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]
Arachidonic Acid results in increased expression of PTGS2 mRNA; Arachidonic Acid results in increased expression of PTGS2 protein
CTD PMID:9013627, PMID:9146894, PMID:11112151, PMID:12538810, PMID:12757841, PMID:12821125, PMID:15684433, PMID:15863457, PMID:15878913, PMID:17092368, PMID:17624748, PMID:18297109, PMID:18388244, PMID:18840450, PMID:19063610, PMID:21163909, PMID:22476691 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Ptp4a1 protein tyrosine phosphatase 4a1 increases expression ISO Arachidonic Acid results in increased expression of PTP4A1 mRNA CTD PMID:16704987 NCBI chr 1:30,940,303...30,949,877
Ensembl chr 1:30,940,302...30,949,309
Ensembl chr 1:30,940,302...30,949,309
JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor (GEF) 2 increases expression ISO Arachidonic Acid results in increased expression of RAPGEF2 mRNA CTD PMID:16704987 NCBI chr 3:79,062,511...79,286,545
Ensembl chr 3:79,062,516...79,286,517
JBrowse link
G Retn resistin decreases expression ISO Arachidonic Acid results in decreased expression of RETN mRNA CTD PMID:15949695 NCBI chr 8:3,655,770...3,659,818
Ensembl chr 8:3,655,770...3,660,110
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 multiple interactions ISO Arachidonic Acid promotes the reaction [Quercetin results in decreased phosphorylation of RPS6KB1 protein] CTD PMID:20551291 NCBI chr11:86,498,869...86,544,885
Ensembl chr11:86,498,871...86,544,805
JBrowse link
G Rxra retinoid X receptor alpha affects binding ISO Arachidonic Acid binds to RXRA protein CTD PMID:16258897 NCBI chr 2:27,676,445...27,763,319
Ensembl chr 2:27,676,440...27,762,957
JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 increases expression ISO Arachidonic Acid results in increased expression of SCD mRNA CTD PMID:21457203 NCBI chr19:44,293,676...44,306,864
Ensembl chr19:44,293,674...44,306,864
JBrowse link
G Selp selectin, platelet increases expression
multiple interactions
ISO Arachidonic Acid results in increased expression of SELP protein
Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of SELP protein]; Glucose inhibits the reaction [Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of SELP protein]]; Quercetin inhibits the reaction [Arachidonic Acid results in increased expression of SELP protein]
CTD PMID:17543677, PMID:18413191, PMID:23249183 NCBI chr 1:164,115,264...164,150,026
Ensembl chr 1:164,115,264...164,150,026
JBrowse link
G Serpinb2 serine (or cysteine) peptidase inhibitor, clade B, member 2 increases expression ISO Arachidonic Acid results in increased expression of SERPINB2 mRNA CTD PMID:18388244 NCBI chr 1:107,500,892...107,525,600
Ensembl chr 1:107,511,423...107,535,478
JBrowse link
G Skp2 S-phase kinase-associated protein 2 decreases expression ISO Arachidonic Acid results in decreased expression of SKP2 mRNA CTD PMID:16704987 NCBI chr15:9,111,982...9,155,425
Ensembl chr15:9,111,985...9,155,425
JBrowse link
G Slc4a2 solute carrier family 4 (anion exchanger), member 2 increases expression EXP Arachidonic Acid results in increased expression of SLC4A2 mRNA CTD PMID:16623957 NCBI chr 5:24,423,761...24,440,947
Ensembl chr 5:24,423,837...24,440,950
JBrowse link
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 increases expression ISO Arachidonic Acid results in increased expression of SLC7A11 mRNA CTD PMID:16704987 NCBI chr 3:50,364,936...50,499,087
Ensembl chr 3:49,892,526...50,443,614
JBrowse link
G Snai2 snail family zinc finger 2 increases expression ISO Arachidonic Acid results in increased expression of SNAI2 mRNA CTD PMID:16704987 NCBI chr16:14,705,852...14,709,395
Ensembl chr16:14,705,852...14,709,385
JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions EXP Arachidonic Acid promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA] CTD PMID:19063610 NCBI chr11:117,966,079...117,970,336
Ensembl chr11:117,966,079...117,970,047
JBrowse link
G Sod1 superoxide dismutase 1, soluble decreases activity
increases activity
multiple interactions
ISO Arachidonic Acid results in decreased activity of SOD1 protein
Arachidonic Acid results in increased activity of SOD1 protein
2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [Arachidonic Acid results in decreased activity of SOD1 protein]; Indomethacin inhibits the reaction [Arachidonic Acid results in decreased activity of SOD1 protein]
CTD PMID:16982041 NCBI chr16:90,220,762...90,226,333
Ensembl chr16:90,220,754...90,226,329
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions
increases activity
increases expression
ISO [Arachidonic Acid results in increased abundance of Reactive Oxygen Species] which results in increased expression of SOD2; Acetylcysteine inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 protein]; Arachidonic Acid results in increased expression of and results in increased activity of SOD2 protein; calphostin C inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 mRNA]; calphostin C inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 protein]; Dactinomycin inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 mRNA]; Indomethacin inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 mRNA]; Indomethacin inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 protein]; Masoprocol inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 mRNA]; Masoprocol inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 protein]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 mRNA]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 protein]; Phenols inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 protein]
Arachidonic Acid results in increased activity of SOD2 protein
2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [Arachidonic Acid results in increased activity of SOD2 protein]; Indomethacin inhibits the reaction [Arachidonic Acid results in increased activity of SOD2 protein]
CTD PMID:12031898, PMID:16982041 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063
JBrowse link
G Sox9 SRY (sex determining region Y)-box 9 decreases expression ISO Arachidonic Acid results in decreased expression of SOX9 mRNA CTD PMID:16704987 NCBI chr11:112,782,210...112,787,757
Ensembl chr11:112,782,224...112,787,760
JBrowse link
G Sparc secreted acidic cysteine rich glycoprotein decreases expression ISO Arachidonic Acid results in decreased expression of SPARC mRNA CTD PMID:16704987 NCBI chr11:55,394,159...55,420,080
Ensembl chr11:55,394,500...55,423,183
JBrowse link
G Spast spastin decreases expression ISO Arachidonic Acid results in decreased expression of SPAST mRNA CTD PMID:16704987 NCBI chr17:74,337,923...74,391,115
Ensembl chr17:74,338,987...74,391,115
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO Arachidonic Acid results in increased expression of SQSTM1 mRNA CTD PMID:16704987 NCBI chr11:50,200,152...50,210,820
Ensembl chr11:50,199,366...50,210,827
JBrowse link
G Srgap2 SLIT-ROBO Rho GTPase activating protein 2 decreases expression ISO Arachidonic Acid results in decreased expression of SRGAP2 mRNA CTD PMID:16704987 NCBI chr 1:131,285,251...131,527,531
Ensembl chr 1:131,285,251...131,527,352
JBrowse link
G Ssr2 signal sequence receptor, beta decreases expression EXP Arachidonic Acid results in decreased expression of SSR2 mRNA CTD PMID:16623957 NCBI chr 3:88,579,608...88,588,420
Ensembl chr 3:88,575,876...88,588,419
JBrowse link
G Star steroidogenic acute regulatory protein increases expression
multiple interactions
ISO Arachidonic Acid results in increased expression of STAR protein
Arachidonic Acid inhibits the reaction [Dimethoate results in decreased expression of STAR protein]
CTD PMID:22476691 NCBI chr 8:25,808,474...25,815,982
Ensembl chr 8:25,806,555...25,815,982
JBrowse link
G Stc2 stanniocalcin 2 increases expression ISO Arachidonic Acid results in increased expression of STC2 mRNA CTD PMID:16704987 NCBI chr11:31,359,441...31,370,061
Ensembl chr11:31,357,307...31,370,074
JBrowse link
G Stk11 serine/threonine kinase 11 multiple interactions ISO STK11 protein affects the reaction [resveratrol results in decreased susceptibility to [Arachidonic Acid co-treated with Iron]] CTD PMID:19620254 NCBI chr10:80,115,767...80,130,679
Ensembl chr10:80,115,803...80,130,682
JBrowse link
G Tfeb transcription factor EB decreases expression EXP Arachidonic Acid results in decreased expression of TFEB mRNA CTD PMID:16623957 NCBI chr17:47,737,037...47,792,416
Ensembl chr17:47,737,030...47,792,419
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TGFB1 mRNA; CYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TGFB1 mRNA] CTD PMID:16581302 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
G Thrsp thyroid hormone responsive decreases expression
multiple interactions
EXP Arachidonic Acid results in decreased expression of THRSP mRNA
Flurbiprofen inhibits the reaction [Arachidonic Acid results in decreased expression of THRSP mRNA]
CTD PMID:10357836 NCBI chr 7:97,412,933...97,417,550
Ensembl chr 7:97,412,938...97,417,730
JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 multiple interactions ISO [ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TIMP1 mRNA; CYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TIMP1 mRNA] CTD PMID:16581302 NCBI chr  X:20,870,166...20,874,737
Ensembl chr  X:20,870,166...20,874,735
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO [Docosahexaenoic Acids co-treated with Arachidonic Acid] affects the expression of TLR4 mRNA; Arachidonic Acid inhibits the reaction [1-O-hexadecyl-2-N-methylcarbamylphosphatidylcholine results in increased expression of TLR4 mRNA] CTD PMID:17515866 NCBI chr 4:66,827,551...66,846,581
Ensembl chr 4:66,827,584...66,930,284
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases abundance
increases secretion
ISO
EXP
Arachidonic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Butylated Hydroxyanisole inhibits the reaction [TNF protein results in increased secretion of Arachidonic Acid]
TNF protein results in increased abundance of Arachidonic Acid
Butylated Hydroxyanisole inhibits the reaction [TNF protein results in increased abundance of Arachidonic Acid]; TNFRSF1A protein affects the reaction [Butylated Hydroxyanisole inhibits the reaction [TNF protein results in increased abundance of Arachidonic Acid]]
CTD PMID:1515551, PMID:10588948, PMID:15684433 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tnfrsf12a tumor necrosis factor receptor superfamily, member 12a increases expression ISO Arachidonic Acid results in increased expression of TNFRSF12A mRNA CTD PMID:16704987 NCBI chr17:23,675,445...23,677,449
Ensembl chr17:23,675,445...23,677,468
JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a multiple interactions EXP TNFRSF1A protein affects the reaction [Butylated Hydroxyanisole inhibits the reaction [TNF protein results in increased abundance of Arachidonic Acid]] CTD PMID:10588948 NCBI chr 6:125,349,723...125,362,483
Ensembl chr 6:125,349,362...125,362,484
JBrowse link
G Tns3 tensin 3 decreases expression ISO Arachidonic Acid results in decreased expression of TNS3 mRNA CTD PMID:16704987 NCBI chr11:8,431,652...8,664,758
Ensembl chr11:8,431,652...8,664,681
JBrowse link
G Top2a topoisomerase (DNA) II alpha decreases expression ISO Arachidonic Acid results in decreased expression of TOP2A mRNA CTD PMID:16704987 NCBI chr11:98,992,947...99,024,199
Ensembl chr11:98,992,943...99,024,189
JBrowse link
G Trp53 transformation related protein 53 multiple interactions EXP
ISO
[TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of Arachidonic Acid
[TP53 protein results in increased expression of ALOX12B mRNA] which results in increased metabolism of Arachidonic Acid; [TP53 protein results in increased expression of ALOX5 mRNA] which results in increased metabolism of Arachidonic Acid
CTD PMID:30258081 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity
multiple interactions
EXP Arachidonic Acid results in increased activity of TRPA1 protein
Ruthenium Red inhibits the reaction [Arachidonic Acid results in increased activity of TRPA1 protein]
CTD PMID:15046718 NCBI chr 1:14,872,644...14,918,862
Ensembl chr 1:14,872,648...14,918,862
JBrowse link
G Trpc4 transient receptor potential cation channel, subfamily C, member 4 multiple interactions ISO TRPC4 protein affects the reaction [Arachidonic Acid results in increased transport of Calcium] CTD PMID:11830588 NCBI chr 3:54,155,584...54,318,471
Ensembl chr 3:54,156,035...54,318,471
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions ISO [Arachidonic Acid co-treated with Phorbol 12,13-Dibutyrate] results in increased activity of TRPV1 protein CTD PMID:17038422 NCBI chr11:73,234,149...73,261,322
Ensembl chr11:73,234,292...73,261,242
JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 increases activity ISO Arachidonic Acid results in increased activity of TRPV4 protein CTD PMID:20956320 NCBI chr 5:114,622,152...114,658,435
Ensembl chr 5:114,622,152...114,658,421
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Arachidonic Acid CTD PMID:15231852 NCBI chr 1:88,211,959...88,220,002
Ensembl chr 1:88,211,959...88,218,997
JBrowse link
G Ugt1a10 UDP glycosyltransferase 1 family, polypeptide A10 increases glucuronidation ISO UGT1A10 protein results in increased glucuronidation of Arachidonic Acid CTD PMID:15231852 NCBI chr 1:88,055,411...88,220,002
Ensembl chr 1:88,055,388...88,219,004
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Arachidonic Acid CTD PMID:15231852 NCBI chr 1:88,200,611...88,220,002
Ensembl chr 1:88,200,601...88,218,997
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase 1 family, polypeptide A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of Arachidonic Acid CTD PMID:15231852 NCBI chr 1:88,166,012...88,220,002
Ensembl chr 1:88,166,012...88,218,997
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase 1 family, polypeptide A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Arachidonic Acid CTD PMID:15231852 NCBI chr 1:88,070,779...88,220,002
Ensembl chr 1:88,070,800...88,218,997
JBrowse link
G Ugt2b34 UDP glucuronosyltransferase 2 family, polypeptide B34 increases glucuronidation ISO UGT2B7 protein results in increased glucuronidation of Arachidonic Acid CTD PMID:15231852 NCBI chr 5:86,889,770...86,906,937
Ensembl chr 5:86,889,767...86,906,937
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression
ISO
EXP
[PTGS2 co-treated with Arachidonic Acid] results in increased expression of VEGFA
[Arachidonic Acid co-treated with VEGFA protein] results in increased phosphorylation of MAPK1 protein; [Arachidonic Acid co-treated with VEGFA protein] results in increased phosphorylation of MAPK3 protein; CYP2C23 mRNA promotes the reaction [[Arachidonic Acid co-treated with VEGFA protein] results in increased phosphorylation of MAPK1 protein]; CYP2C23 mRNA promotes the reaction [[Arachidonic Acid co-treated with VEGFA protein] results in increased phosphorylation of MAPK3 protein]
Arachidonic Acid results in increased expression of VEGFA mRNA
CTD PMID:12821125, PMID:18388244, PMID:19464254 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369
JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide increases expression ISO Arachidonic Acid results in increased expression of YWHAZ mRNA CTD PMID:16704987 NCBI chr15:36,770,261...36,802,984
Ensembl chr15:36,770,770...36,796,929
JBrowse link
G Zfp36 zinc finger protein 36 increases expression EXP Arachidonic Acid results in increased expression of ZFP36 mRNA CTD PMID:8764118 NCBI chr 7:28,376,784...28,379,228
Ensembl chr 7:28,376,784...28,380,253
JBrowse link
arachidonoyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO arachidonyl-coenzyme A binds to and results in increased activity of PPARA protein CTD PMID:11139385 NCBI chr15:85,734,910...85,806,851
Ensembl chr15:85,734,983...85,802,819
JBrowse link
cholesteryl arachidonate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lipc lipase, hepatic multiple interactions EXP [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl arachidonate CTD PMID:24777581 NCBI chr 9:70,798,128...70,952,221
Ensembl chr 9:70,798,128...70,952,226
JBrowse link
G Lipg lipase, endothelial multiple interactions
decreases abundance
EXP [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl arachidonate
LIPG gene mutant form results in decreased abundance of cholesteryl arachidonate
CTD PMID:24777581 NCBI chr18:74,939,322...74,961,263
Ensembl chr18:74,939,322...74,961,263
JBrowse link
cholesteryl linoleate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lipc lipase, hepatic multiple interactions EXP [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl linoleate CTD PMID:24777581 NCBI chr 9:70,798,128...70,952,221
Ensembl chr 9:70,798,128...70,952,226
JBrowse link
G Lipg lipase, endothelial multiple interactions
affects abundance
EXP [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl linoleate
LIPG gene mutant form affects the abundance of cholesteryl linoleate
CTD PMID:24777581 NCBI chr18:74,939,322...74,961,263
Ensembl chr18:74,939,322...74,961,263
JBrowse link
gamma-linolenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c6 aldo-keto reductase family 1, member C6 increases expression ISO gamma-Linolenic Acid results in increased expression of AKR1C4 mRNA CTD PMID:20664735 NCBI chr13:4,434,311...4,457,530
Ensembl chr13:4,434,306...4,457,877
JBrowse link
G Apoh apolipoprotein H decreases expression ISO gamma-Linolenic Acid results in decreased expression of APOH mRNA CTD PMID:20664735 NCBI chr11:108,395,297...108,414,396
Ensembl chr11:108,343,354...108,414,396
JBrowse link
G Ar androgen receptor multiple interactions ISO gamma-Linolenic Acid inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 NCBI chr  X:98,148,757...98,323,218
Ensembl chr  X:98,148,769...98,323,215
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO gamma-Linolenic Acid results in increased expression of ASAH1 mRNA CTD PMID:20664735 NCBI chr 8:41,340,646...41,397,644
Ensembl chr 8:41,340,197...41,374,773
JBrowse link
G Casp3 caspase 3 increases activity ISO gamma-Linolenic Acid results in increased activity of CASP3 protein CTD PMID:16857180 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO gamma-Linolenic Acid results in decreased expression of CCNA2 protein CTD PMID:15318936 NCBI chr 3:36,564,865...36,573,038
Ensembl chr 3:36,564,865...36,572,150
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO gamma-Linolenic Acid results in decreased expression of CCNE1 protein CTD PMID:15318936 NCBI chr 7:38,097,984...38,107,490
Ensembl chr 7:38,097,984...38,107,534
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO gamma-Linolenic Acid results in decreased expression of CDK1 protein CTD PMID:15318936 NCBI chr10:69,335,146...69,352,912
Ensembl chr10:69,335,146...69,352,938
JBrowse link
G Cldn5 claudin 5 multiple interactions ISO [gamma-Linolenic Acid co-treated with Iodine co-treated with Selenium] results in increased expression of and results in increased localization of CLDN5 protein; [gamma-Linolenic Acid co-treated with Iodine] results in increased expression of and results in increased localization of CLDN5 protein; [Selenium co-treated with gamma-Linolenic Acid] results in increased expression of and results in increased localization of CLDN5 protein; gamma-Linolenic Acid results in increased expression of and results in increased localization of CLDN5 protein CTD PMID:16514648 NCBI chr16:18,776,847...18,778,262
Ensembl chr16:18,776,847...18,778,262
JBrowse link
G Clta clathrin, light polypeptide (Lca) increases expression ISO gamma-Linolenic Acid results in increased expression of CLTA mRNA CTD PMID:20664735 NCBI chr 4:44,003,816...44,032,846
Ensembl chr 4:44,004,452...44,032,846
JBrowse link
G Fth1 ferritin heavy polypeptide 1 increases expression ISO gamma-Linolenic Acid results in increased expression of FTH1 mRNA CTD PMID:20664735 NCBI chr19:9,980,600...9,985,111
Ensembl chr19:9,980,598...9,985,098
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases activity
increases expression
ISO gamma-Linolenic Acid results in increased activity of GCLC protein
gamma-Linolenic Acid results in increased expression of GCLC mRNA
CTD PMID:17092368 NCBI chr 9:77,754,535...77,794,489
Ensembl chr 9:77,754,535...77,794,485
JBrowse link
G Gm40318 predicted gene, 40318 increases expression ISO gamma-Linolenic Acid results in increased expression of S100P mRNA CTD PMID:20664735 NCBI chr 5:36,762,504...36,767,419
Ensembl chr 5:36,762,617...36,766,695
JBrowse link
G Grk5 G protein-coupled receptor kinase 5 increases expression ISO gamma-Linolenic Acid results in increased expression of GRK5 mRNA CTD PMID:20664735 NCBI chr19:60,889,560...61,095,968
Ensembl chr19:60,889,749...61,095,968
JBrowse link
G Hexb hexosaminidase B increases expression ISO gamma-Linolenic Acid results in increased expression of HEXB mRNA CTD PMID:20664735 NCBI chr13:97,176,331...97,198,357
Ensembl chr13:97,176,331...97,198,357
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO gamma-Linolenic Acid results in increased expression of HMOX1 mRNA; gamma-Linolenic Acid results in increased expression of HMOX1 protein CTD PMID:17092368, PMID:20664735 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Il2 interleukin 2 affects expression ISO gamma-Linolenic Acid affects the expression of IL2 protein CTD PMID:9415022 NCBI chr 3:37,120,713...37,125,954
Ensembl chr 3:37,120,523...37,125,959
JBrowse link
G Junb jun B proto-oncogene decreases expression ISO gamma-Linolenic Acid results in decreased expression of JUNB protein CTD PMID:15318936 NCBI chr 8:84,976,909...84,978,748
Ensembl chr 8:84,974,484...84,978,718
Ensembl chr 8:84,974,484...84,978,718
JBrowse link
G Kynu kynureninase decreases expression ISO gamma-Linolenic Acid results in decreased expression of KYNU mRNA CTD PMID:20664735 NCBI chr 2:43,555,258...43,683,048
Ensembl chr 2:43,555,329...43,682,715
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 decreases expression ISO gamma-Linolenic Acid results in decreased expression of MAPK3 protein CTD PMID:15318936 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mmp11 matrix metallopeptidase 11 decreases expression ISO gamma-Linolenic Acid results in decreased expression of MMP11 mRNA CTD PMID:20664735 NCBI chr10:75,923,221...75,932,502
Ensembl chr10:75,923,222...75,936,496
JBrowse link
G Myc myelocytomatosis oncogene decreases expression ISO gamma-Linolenic Acid results in decreased expression of MYC protein CTD PMID:15318936 NCBI chr15:61,985,341...61,990,361
Ensembl chr15:61,985,391...61,990,374
JBrowse link
G Ocln occludin multiple interactions ISO [gamma-Linolenic Acid co-treated with Iodine co-treated with Selenium] results in increased expression of and results in increased localization of OCLN protein; [gamma-Linolenic Acid co-treated with Iodine] results in increased expression of and results in increased localization of OCLN protein; [Selenium co-treated with gamma-Linolenic Acid] results in increased expression of and results in increased localization of OCLN protein; gamma-Linolenic Acid results in increased expression of and results in increased localization of OCLN protein CTD PMID:16514648 NCBI chr13:100,496,504...100,552,718
Ensembl chr13:100,496,507...100,552,718
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage EXP gamma-Linolenic Acid results in increased cleavage of PARP1 protein CTD PMID:10403056 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO gamma-Linolenic Acid results in decreased expression of PCNA mRNA CTD PMID:20664735 NCBI chr 2:132,249,286...132,253,180
Ensembl chr 2:132,249,162...132,253,314
JBrowse link
G Pdlim1 PDZ and LIM domain 1 (elfin) decreases expression ISO gamma-Linolenic Acid results in decreased expression of PDLIM1 mRNA CTD PMID:20664735 NCBI chr19:40,222,239...40,271,616
Ensembl chr19:40,221,173...40,271,842
JBrowse link
G Plin2 perilipin 2 increases expression ISO gamma-Linolenic Acid results in increased expression of PLIN2 mRNA CTD PMID:20664735 NCBI chr 4:86,626,910...86,670,217
Ensembl chr 4:86,648,386...86,670,060
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO gamma-Linolenic Acid binds to and results in increased activity of PPARA protein CTD PMID:10403814 NCBI chr15:85,734,910...85,806,851
Ensembl chr15:85,734,983...85,802,819
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions ISO gamma-Linolenic Acid binds to and results in increased activity of PPARG protein CTD PMID:15318936 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Ptgr1 prostaglandin reductase 1 increases expression ISO gamma-Linolenic Acid results in increased expression of PTGR1 mRNA CTD PMID:20664735 NCBI chr 4:58,965,590...58,987,131
Ensembl chr 4:58,965,439...58,987,119
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO gamma-Linolenic Acid results in increased expression of PTGS2 mRNA CTD PMID:17092368 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Skp2 S-phase kinase-associated protein 2 decreases expression ISO gamma-Linolenic Acid results in decreased expression of SKP2 mRNA CTD PMID:20664735 NCBI chr15:9,111,982...9,155,425
Ensembl chr15:9,111,985...9,155,425
JBrowse link
G Slc3a2 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 increases expression ISO gamma-Linolenic Acid results in increased expression of SLC3A2 mRNA CTD PMID:20664735 NCBI chr19:8,706,882...8,723,369
Ensembl chr19:8,706,882...8,723,369
JBrowse link
G St13 suppression of tumorigenicity 13 increases expression ISO gamma-Linolenic Acid results in increased expression of ST13 mRNA CTD PMID:20664735 NCBI chr15:81,365,044...81,399,694
Ensembl chr15:81,363,669...81,400,077
JBrowse link
G Tff3 trefoil factor 3, intestinal decreases expression ISO gamma-Linolenic Acid results in decreased expression of TFF3 mRNA CTD PMID:20664735 NCBI chr17:31,125,306...31,129,611
Ensembl chr17:31,125,306...31,129,646
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO [gamma-Linolenic Acid co-treated with Iodine co-treated with Selenium] results in increased expression of and results in increased localization of TJP1 protein CTD PMID:16514648 NCBI chr 7:65,296,165...65,527,850
Ensembl chr 7:65,296,165...65,527,781
JBrowse link
G Tnf tumor necrosis factor decreases expression ISO gamma-Linolenic Acid results in decreased expression of TNF protein CTD PMID:9415022 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions ISO gamma-Linolenic Acid inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein] CTD PMID:17038422 NCBI chr11:73,234,149...73,261,322
Ensembl chr11:73,234,292...73,261,242
JBrowse link
G Txn1 thioredoxin 1 increases expression ISO gamma-Linolenic Acid results in increased expression of TXN mRNA CTD PMID:20664735 NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO gamma-Linolenic Acid results in increased expression of TXNRD1 mRNA CTD PMID:20664735 NCBI chr10:82,833,951...82,897,724
Ensembl chr10:82,833,951...82,897,712
JBrowse link
linoleamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pparg peroxisome proliferator activated receptor gamma increases activity ISO linoleamide analog results in increased activity of PPARG protein CTD PMID:29288688 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
linoleic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 1810013A23Rik RIKEN cDNA 1810013A23 gene multiple interactions ISO Linoleic Acid binds to and results in increased activity of PPARB protein CTD PMID:16731579 NCBI chr17:28,271,708...28,273,163
Ensembl chr17:28,232,700...28,301,474
JBrowse link
G Abca1 ATP-binding cassette, sub-family A (ABC1), member 1 multiple interactions
decreases expression
increases expression
increases phosphorylation
increases degradation
ISO
EXP
1-Butanol inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased export of Cholesterol]]; Linoleic Acid inhibits the reaction [ABCA1 protein results in increased export of Cholesterol]; Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]; Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]]; PLD2 protein inhibits the reaction [Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]]; triacsin C inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased transport of Cholesterol]]; triacsin C inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased transport of Phospholipids]]; triacsin C inhibits the reaction [Linoleic Acid results in increased degradation of ABCA1 protein]
Linoleic Acid analog results in decreased expression of ABCA1 mRNA
Linoleic Acid results in increased expression of ABCA1 mRNA
Linoleic Acid inhibits the reaction [27-hydroxycholesterol results in increased expression of ABCA1 mRNA]
Linoleic Acid results in increased phosphorylation of ABCA1 protein
CTD PMID:16118212, PMID:18356535, PMID:27939595 NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 decreases expression ISO Linoleic Acid results in decreased expression of ABCG1 mRNA; Linoleic Acid results in decreased expression of ABCG1 protein CTD PMID:16730733 NCBI chr17:31,057,694...31,117,984
Ensembl chr17:31,057,675...31,117,988
JBrowse link
G Acaca acetyl-Coenzyme A carboxylase alpha decreases expression ISO Linoleic Acid results in decreased expression of ACACA mRNA CTD PMID:14563831 NCBI chr11:84,129,635...84,401,651
Ensembl chr11:84,129,672...84,401,651
JBrowse link
G Acadm acyl-Coenzyme A dehydrogenase, medium chain increases expression ISO Linoleic Acid results in increased expression of ACADM mRNA CTD PMID:23056435 NCBI chr 3:153,922,353...153,944,643
Ensembl chr 3:153,922,357...153,944,632
JBrowse link
G Acly ATP citrate lyase decreases expression ISO Linoleic Acid results in decreased expression of ACLY mRNA CTD PMID:14563831 NCBI chr11:100,476,352...100,528,000
Ensembl chr11:100,476,353...100,528,000
JBrowse link
G Acmsd amino carboxymuconate semialdehyde decarboxylase decreases expression ISO Linoleic Acid results in decreased expression of ACMSD mRNA CTD PMID:18320257 NCBI chr 1:127,729,413...127,767,564
Ensembl chr 1:127,729,413...127,767,978
JBrowse link
G Acox1 acyl-Coenzyme A oxidase 1, palmitoyl increases expression ISO Linoleic Acid results in increased expression of ACOX1 mRNA CTD PMID:18320257 NCBI chr11:116,171,883...116,199,045
Ensembl chr11:116,171,888...116,199,045
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression EXP Linoleic Acid results in decreased expression of ADIPOQ mRNA CTD PMID:17374693 NCBI chr16:23,146,536...23,157,968
Ensembl chr16:23,146,536...23,158,028
JBrowse link
G Adipor1 adiponectin receptor 1 increases expression EXP Linoleic Acid analog results in increased expression of ADIPOR1 mRNA CTD PMID:27939595 NCBI chr 1:134,415,378...134,433,351
Ensembl chr 1:134,415,378...134,433,351
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO AGER protein results in increased susceptibility to [Azoxymethane co-treated with Glucose co-treated with Linoleic Acid]; Glucose promotes the reaction [Linoleic Acid promotes the reaction [Azoxymethane results in increased expression of AGER protein]]; Linoleic Acid promotes the reaction [Azoxymethane results in increased expression of AGER protein]; Linoleic Acid promotes the reaction [Glucose promotes the reaction [Azoxymethane results in increased expression of AGER protein]]; Losartan inhibits the reaction [Glucose promotes the reaction [Linoleic Acid promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]; Losartan inhibits the reaction [Linoleic Acid promotes the reaction [Glucose promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]; Metformin inhibits the reaction [Glucose promotes the reaction [Linoleic Acid promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]; Metformin inhibits the reaction [Linoleic Acid promotes the reaction [Glucose promotes the reaction [Azoxymethane results in increased expression of AGER protein]]] CTD PMID:22467055 NCBI chr17:34,597,460...34,600,937
Ensembl chr17:34,597,862...34,600,936
JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions ISO Linoleic Acid inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]]; Linoleic Acid inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PTGS2 promoter]] CTD PMID:18001219 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Alox15 arachidonate 15-lipoxygenase increases oxidation ISO ALOX15 protein results in increased oxidation of Linoleic Acid CTD PMID:25786526 NCBI chr11:70,344,147...70,390,538
Ensembl chr11:70,344,152...70,352,031
JBrowse link
G Apoa1 apolipoprotein A-I multiple interactions ISO Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]; Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]]; PLD2 protein inhibits the reaction [Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]] CTD PMID:16118212 NCBI chr 9:46,228,630...46,230,469
Ensembl chr 9:46,228,580...46,230,466
JBrowse link
G Ascl2 achaete-scute family bHLH transcription factor 2 decreases expression ISO Linoleic Acid results in decreased expression of ASCL2 mRNA CTD PMID:15708366 NCBI chr 7:142,966,822...142,969,264
Ensembl chr 7:142,966,829...142,969,264
JBrowse link
G Bche butyrylcholinesterase increases expression ISO Linoleic Acid results in increased expression of BCHE mRNA CTD PMID:27106529 NCBI chr 3:73,635,805...73,708,436
Ensembl chr 3:73,635,808...73,708,415
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO [Linoleic Acid co-treated with Glucose] affects the reaction [Azoxymethane affects the expression of BCL2 protein]; Linoleic Acid affects the reaction [Azoxymethane affects the expression of BCL2 protein] CTD PMID:22467055 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Cat catalase increases expression ISO Linoleic Acid results in increased expression of CAT protein CTD PMID:10946007 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 increases expression ISO Linoleic Acid results in increased expression of CCL2 protein CTD PMID:16305726 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Cd36 CD36 molecule multiple interactions ISO [Oleic Acid co-treated with Linoleic Acid] results in increased expression of CD36 mRNA CTD PMID:28552552 NCBI chr 5:17,781,690...17,888,959
Ensembl chr 5:17,781,690...17,888,801
JBrowse link
G Cnr1 cannabinoid receptor 1 (brain) multiple interactions
affects response to substance
EXP CNR1 protein affects the reaction [Linoleic Acid results in increased secretion of GCG protein]
CNR1 protein affects the susceptibility to Linoleic Acid
CTD PMID:30241419 NCBI chr 4:33,923,171...33,948,831
Ensembl chr 4:33,924,593...33,948,831
JBrowse link
G Col1a1 collagen, type I, alpha 1 increases expression EXP Linoleic Acid results in increased expression of COL1A1 mRNA CTD PMID:26240151 NCBI chr11:94,936,224...94,953,042
Ensembl chr11:94,936,224...94,953,042
JBrowse link
G Col3a1 collagen, type III, alpha 1 decreases expression EXP Linoleic Acid results in decreased expression of COL3A1 mRNA CTD PMID:26240151 NCBI chr 1:45,311,538...45,349,706
Ensembl chr 1:45,311,538...45,349,706
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver increases expression ISO Linoleic Acid results in increased expression of CPT1A mRNA CTD PMID:11171094 NCBI chr19:3,322,326...3,385,735
Ensembl chr19:3,322,334...3,385,733
JBrowse link
G Crebbp CREB binding protein multiple interactions ISO Linoleic Acid affects the reaction [PPARA protein binds to CREBBP protein] CTD PMID:19263263 NCBI chr16:4,081,334...4,213,957
Ensembl chr16:4,081,328...4,213,997
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [Oleic Acid co-treated with Linoleic Acid] results in increased expression of CYCS protein CTD PMID:27016407 NCBI chr 6:50,562,563...50,566,569
Ensembl chr 6:50,562,563...50,566,538
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Linoleic Acid inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]] CTD PMID:18001219 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Linoleic Acid results in decreased activity of CYP1A2 protein CTD PMID:16978661 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp2a4 cytochrome P450, family 2, subfamily a, polypeptide 4 increases expression
multiple interactions
ISO Linoleic Acid results in increased expression of CYP2A6 mRNA; Linoleic Acid results in increased expression of CYP2A6 protein
NFE2L2 protein promotes the reaction [Linoleic Acid results in increased expression of CYP2A6 mRNA]; NFE2L2 protein promotes the reaction [Linoleic Acid results in increased expression of CYP2A6 protein]
CTD PMID:28555106 NCBI chr 7:26,307,192...26,315,088
Ensembl chr 7:26,307,169...26,315,088
JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 multiple interactions
decreases activity
ISO CYP2C19 protein results in increased metabolism of [Linoleic Acid co-treated with NADP]
Linoleic Acid results in decreased activity of CYP2C19 protein
CTD PMID:16978661 NCBI chr19:39,389,556...39,463,103
Ensembl chr19:39,389,556...39,463,075
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 multiple interactions
decreases activity
ISO CYP2C9 protein results in increased metabolism of [Linoleic Acid co-treated with NADP]
Linoleic Acid results in decreased activity of CYP2C9 protein
CTD PMID:16978661 NCBI chr19:39,061,006...39,093,948
Ensembl chr19:39,061,015...39,093,944
JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 multiple interactions
decreases activity
ISO CYP2C9 protein results in increased metabolism of [Linoleic Acid co-treated with NADP]
Linoleic Acid results in decreased activity of CYP2C9 protein
CTD PMID:16978661 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Linoleic Acid results in decreased activity of CYP2E1 protein CTD PMID:16978661 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 decreases activity ISO Linoleic Acid results in decreased activity of CYP3A4 protein CTD PMID:16978661 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression EXP Linoleic Acid analog results in increased expression of DDIT3 protein CTD PMID:27939595 NCBI chr10:127,290,793...127,296,291
Ensembl chr10:127,290,774...127,296,288
Ensembl chr10:127,290,774...127,296,288
JBrowse link
G Dio1 deiodinase, iodothyronine, type I decreases activity ISO Linoleic Acid results in decreased activity of DIO1 protein CTD PMID:30561685 NCBI chr 4:107,291,465...107,307,168
Ensembl chr 4:107,291,465...107,307,169
JBrowse link
G Dio2 deiodinase, iodothyronine, type II decreases activity ISO Linoleic Acid results in decreased activity of DIO2 protein CTD PMID:30561685 NCBI chr12:90,724,552...90,739,038
Ensembl chr12:90,724,552...90,738,438
JBrowse link
G Dio3 deiodinase, iodothyronine type III decreases activity ISO Linoleic Acid results in decreased activity of DIO3 protein CTD PMID:30561685 NCBI chr12:110,279,230...110,281,097
Ensembl chr12:110,279,068...110,281,097
JBrowse link
G Edn1 endothelin 1 decreases expression ISO Linoleic Acid results in decreased expression of EDN1 mRNA; Linoleic Acid results in decreased expression of EDN1 protein CTD PMID:16895544 NCBI chr13:42,301,476...42,307,990
Ensembl chr13:42,301,476...42,307,990
JBrowse link
G Fabp1 fatty acid binding protein 1, liver decreases expression ISO Linoleic Acid results in decreased expression of FABP1 mRNA CTD PMID:15708366 NCBI chr 6:71,199,879...71,205,034
Ensembl chr 6:71,199,827...71,205,023
JBrowse link
G Fabp3 fatty acid binding protein 3, muscle and heart decreases expression ISO Linoleic Acid results in decreased expression of FABP3 mRNA CTD PMID:15708366 NCBI chr 4:130,308,738...130,315,463
Ensembl chr 4:130,308,595...130,315,463
JBrowse link
G Fabp4 fatty acid binding protein 4, adipocyte affects localization EXP Linoleic Acid analog affects the localization of FABP4 protein CTD PMID:27939595 NCBI chr 3:10,204,342...10,208,616
Ensembl chr 3:10,204,088...10,208,576
JBrowse link
G Fads2 fatty acid desaturase 2 multiple interactions
increases expression
ISO
EXP
[Linoleic Acid co-treated with Testosterone] results in increased expression of FADS2 mRNA
FADS2 protein inhibits the reaction [Linoleic Acid results in increased activity of LOX protein]
Linoleic Acid results in increased expression of FADS2 mRNA; Linoleic Acid results in increased expression of FADS2 protein
CTD PMID:21457203, PMID:26240151 NCBI chr19:10,062,765...10,101,503
Ensembl chr19:10,062,765...10,101,746
JBrowse link
G Fasn fatty acid synthase decreases expression ISO Linoleic Acid results in decreased expression of FASN mRNA CTD PMID:14563831 NCBI chr11:120,805,958...120,825,166
Ensembl chr11:120,805,846...120,824,547
JBrowse link
G Ffar3 free fatty acid receptor 3 increases expression EXP Linoleic Acid analog results in increased expression of FFAR3 mRNA CTD PMID:27939595 NCBI chr 7:30,854,330...30,856,178
Ensembl chr 7:30,854,330...30,856,178
JBrowse link
G Foxo1 forkhead box O1 decreases expression EXP Linoleic Acid results in decreased expression of FOXO1 protein CTD PMID:17374693 NCBI chr 3:52,268,337...52,350,109
Ensembl chr 3:52,268,336...52,353,221
JBrowse link
G Gcg glucagon multiple interactions EXP CNR1 protein affects the reaction [Linoleic Acid results in increased secretion of GCG protein] CTD PMID:30241419 NCBI chr 2:62,474,530...62,483,653
Ensembl chr 2:62,474,530...62,483,650
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression ISO Linoleic Acid metabolite results in increased expression of GCLM mRNA CTD PMID:26879219 NCBI chr 3:122,245,487...122,267,215
Ensembl chr 3:122,245,557...122,270,732
JBrowse link
G Gjb1 gap junction protein, beta 1 increases abundance EXP GJB1 protein results in increased abundance of Linoleic Acid CTD PMID:27859493 NCBI chr  X:101,376,376...101,385,629
Ensembl chr  X:101,376,378...101,385,629
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression EXP Linoleic Acid metabolite results in increased expression of GSTA4 mRNA CTD PMID:26879219 NCBI chr 9:78,289,928...78,305,525
Ensembl chr 9:78,289,923...78,305,525
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
NFE2L2 mRNA promotes the reaction [Linoleic Acid metabolite results in increased expression of HMOX1 mRNA]
Linoleic Acid metabolite results in increased expression of HMOX1 mRNA; Linoleic Acid metabolite results in increased expression of HMOX1 protein
CTD PMID:26879219 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hspa5 heat shock protein 5 increases expression EXP Linoleic Acid analog results in increased expression of HSPA5 protein CTD PMID:27939595 NCBI chr 2:34,772,090...34,776,529
Ensembl chr 2:34,771,970...34,777,547
JBrowse link
G Ifng interferon gamma increases expression ISO Linoleic Acid results in increased expression of IFNG protein CTD PMID:16305726 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Il10 interleukin 10 increases expression ISO Linoleic Acid results in increased expression of IL10 protein CTD PMID:16305726 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il1b interleukin 1 beta increases expression ISO Linoleic Acid results in increased expression of IL1B protein CTD PMID:16305726 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il2 interleukin 2 decreases expression ISO Linoleic Acid results in decreased expression of IL2 protein CTD PMID:16305726 NCBI chr 3:37,120,713...37,125,954
Ensembl chr 3:37,120,523...37,125,959
JBrowse link
G Il4 interleukin 4 decreases expression ISO Linoleic Acid results in decreased expression of IL4 protein CTD PMID:16305726 NCBI chr11:53,612,460...53,618,665
Ensembl chr11:53,602,982...53,618,669
JBrowse link
G Il5 interleukin 5 decreases expression ISO Linoleic Acid results in decreased expression of IL5 protein CTD PMID:16305726 NCBI chr11:53,720,794...53,725,103
Ensembl chr11:53,720,794...53,725,106
JBrowse link
G Il6 interleukin 6 affects expression
increases expression
increases secretion
ISO
EXP
Linoleic Acid affects the expression of IL6 protein
Linoleic Acid results in increased expression of IL6 mRNA
Linoleic Acid results in increased secretion of IL6 protein
CTD PMID:16305726, PMID:17374693, PMID:21457203 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Insr insulin receptor increases expression EXP Linoleic Acid analog results in increased expression of INSR mRNA CTD PMID:27939595 NCBI chr 8:3,150,922...3,279,649
Ensembl chr 8:3,122,061...3,279,617
JBrowse link
G Lcat lecithin cholesterol acyltransferase increases expression EXP Linoleic Acid analog results in increased expression of LCAT mRNA CTD PMID:27939595 NCBI chr 8:105,939,551...105,943,402
Ensembl chr 8:105,939,551...105,943,382
JBrowse link
G Lipc lipase, hepatic multiple interactions EXP [LIPC gene mutant form co-treated with LIPG gene mutant form] results in decreased abundance of Linoleic Acid CTD PMID:24777581 NCBI chr 9:70,798,128...70,952,221
Ensembl chr 9:70,798,128...70,952,226
JBrowse link
G Lipg lipase, endothelial multiple interactions EXP [LIPC gene mutant form co-treated with LIPG gene mutant form] results in decreased abundance of Linoleic Acid CTD PMID:24777581 NCBI chr18:74,939,322...74,961,263
Ensembl chr18:74,939,322...74,961,263
JBrowse link
G Lox lysyl oxidase multiple interactions
increases activity
EXP FADS2 protein inhibits the reaction [Linoleic Acid results in increased activity of LOX protein]; TGFB1 protein promotes the reaction [Linoleic Acid results in increased activity of LOX protein] CTD PMID:26240151 NCBI chr18:52,516,060...52,529,867
Ensembl chr18:52,516,067...52,529,867
JBrowse link
G Lpin1 lipin 1 decreases expression EXP Linoleic Acid analog results in decreased expression of LPIN1 mRNA CTD PMID:27939595 NCBI chr12:16,535,669...16,653,903
Ensembl chr12:16,535,669...16,646,966
JBrowse link
G Lrat lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase) increases expression ISO Linoleic Acid results in increased expression of LRAT mRNA CTD PMID:12576510 NCBI chr 3:82,892,582...82,903,974
Ensembl chr 3:82,892,579...82,903,973
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO Linoleic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:23288142 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
ISO Linoleic Acid results in decreased expression of and results in decreased activity of MMP9 protein
[Linoleic Acid co-treated with Glucose] affects the reaction [Azoxymethane affects the expression of MMP9 protein]; Linoleic Acid affects the reaction [Azoxymethane affects the expression of MMP9 protein]
Linoleic Acid results in decreased expression of MMP9 mRNA
CTD PMID:22467055, PMID:23288142 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO Linoleic Acid affects the reaction [Zymosan analog affects the localization of NCF1 protein] CTD PMID:12101222 NCBI chr 5:134,220,053...134,229,628
Ensembl chr 5:134,220,053...134,229,625
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 multiple interactions ISO Linoleic Acid affects the reaction [Zymosan analog affects the localization of NCF2 protein] CTD PMID:12101222 NCBI chr 1:152,800,153...152,836,990
Ensembl chr 1:152,800,194...152,836,991
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Linoleic Acid promotes the reaction [PPARA protein binds to NCOA1 protein] CTD PMID:19263263 NCBI chr12:4,247,362...4,477,206
Ensembl chr12:4,247,362...4,477,182
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Linoleic Acid promotes the reaction [PPARA protein binds to NCOA2 protein] CTD PMID:19263263 NCBI chr 1:13,139,105...13,374,227
Ensembl chr 1:13,139,105...13,374,083
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases expression
multiple interactions
ISO
EXP
Linoleic Acid metabolite results in increased expression of NFE2L2 protein; Linoleic Acid results in increased expression of NFE2L2 mRNA; Linoleic Acid results in increased expression of NFE2L2 protein
NFE2L2 mRNA promotes the reaction [Linoleic Acid metabolite results in increased expression of HMOX1 mRNA]; NFE2L2 protein promotes the reaction [Linoleic Acid results in increased expression of CYP2A6 mRNA]; NFE2L2 protein promotes the reaction [Linoleic Acid results in increased expression of CYP2A6 protein]; NFE2L2 protein promotes the reaction [Linoleic Acid results in increased expression of GSTA1 mRNA]
CTD PMID:26879219, PMID:28555106 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO [Linoleic Acid co-treated with Glucose] affects the reaction [Azoxymethane affects the expression of NOS2 protein]; Linoleic Acid affects the reaction [Azoxymethane affects the expression of NOS2 protein] CTD PMID:22467055 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell decreases expression ISO Linoleic Acid results in decreased expression of NOS3 mRNA CTD PMID:16895544 NCBI chr 5:24,364,816...24,384,474
Ensembl chr 5:24,364,810...24,384,474
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression ISO
EXP
Linoleic Acid metabolite results in increased expression of NQO1 mRNA CTD PMID:26879219 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 multiple interactions EXP [NR5A2 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Linoleic Acid analog CTD PMID:29515023 NCBI chr 1:136,842,562...136,960,448
Ensembl chr 1:136,842,571...136,960,448
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic multiple interactions EXP [Glucose deficiency co-treated with Linoleic Acid] results in increased expression of PCK1 mRNA CTD PMID:8536680 NCBI chr 2:173,153,073...173,159,274
Ensembl chr 2:173,153,048...173,159,273
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase, isoenzyme 4 increases expression ISO Linoleic Acid results in increased expression of PDK4 mRNA CTD PMID:23056435 NCBI chr 6:5,483,351...5,496,278
Ensembl chr 6:5,483,351...5,496,309
JBrowse link
G Pld2 phospholipase D2 multiple interactions ISO PLD2 protein inhibits the reaction [Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]] CTD PMID:16118212 NCBI chr11:70,539,492...70,558,110
Ensembl chr11:70,540,064...70,558,110
JBrowse link
G Plin1 perilipin 1 increases expression EXP Linoleic Acid analog results in increased expression of PLIN1 mRNA CTD PMID:27939595 NCBI chr 7:79,721,164...79,732,904
Ensembl chr 7:79,720,218...79,732,903
JBrowse link
G Pon1 paraoxonase 1 multiple interactions
decreases activity
ISO Linoleic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; Linoleic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid]
Linoleic Acid results in decreased activity of PON1 protein
CTD PMID:12871208, PMID:15375178 NCBI chr 6:5,168,090...5,193,987
Ensembl chr 6:5,168,090...5,193,946
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases expression
affects abundance
increases activity
affects binding
ISO
EXP
[Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased oxidation of Linoleic Acid; Linoleic Acid affects the reaction [PPARA protein binds to CREBBP protein]; Linoleic Acid binds to and results in increased activity of PPARA protein; Linoleic Acid promotes the reaction [PPARA protein binds to NCOA1 protein]; Linoleic Acid promotes the reaction [PPARA protein binds to NCOA2 protein]
Linoleic Acid results in increased expression of PPARA mRNA
PPARA protein affects the abundance of Linoleic Acid
Diethylhexyl Phthalate inhibits the reaction [PPARA protein affects the abundance of Linoleic Acid]; Linoleic Acid binds to and results in increased activity of PPARA protein
Linoleic Acid results in increased expression of PPARA mRNA; Linoleic Acid results in increased expression of PPARA protein
Linoleic Acid results in increased activity of PPARA protein
Linoleic Acid binds to PPARA protein
CTD PMID:10403814, PMID:11172467, PMID:15491415, PMID:16731579, PMID:18154422, PMID:19263263, PMID:20404010, PMID:23056435, PMID:23619606, PMID:23843199, PMID:25786526 NCBI chr15:85,734,910...85,806,851
Ensembl chr15:85,734,983...85,802,819
JBrowse link
G Ppard peroxisome proliferator activator receptor delta multiple interactions
decreases expression
affects binding
increases expression
increases activity
EXP
ISO
Linoleic Acid binds to and results in increased activity of PPARB protein
Linoleic Acid results in decreased expression of PPARD mRNA
Linoleic Acid binds to PPARB protein
Linoleic Acid results in increased expression of PPARD mRNA
Linoleic Acid results in increased activity of PPARD protein
CTD PMID:11172467, PMID:15708366, PMID:16731579, PMID:23843199, PMID:25786526 NCBI chr17:28,232,754...28,301,469
Ensembl chr17:28,232,700...28,301,474
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma affects binding
multiple interactions
increases expression
increases activity
decreases expression
ISO
EXP
Linoleic Acid binds to PPARG protein
Linoleic Acid binds to and results in increased activity of PPARG protein
Linoleic Acid results in increased expression of PPARG mRNA
resveratrol inhibits the reaction [Linoleic Acid results in increased expression of PPARG protein]
Linoleic Acid results in increased activity of PPARG protein
Linoleic Acid results in decreased expression of PPARG mRNA; Linoleic Acid results in decreased expression of PPARG protein
CTD PMID:11172467, PMID:12021203, PMID:15708366, PMID:16731579, PMID:18154422, PMID:23843199, PMID:25672876, PMID:25786526 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha increases expression ISO Linoleic Acid results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr 5:51,454,249...52,115,853
Ensembl chr 5:51,454,250...51,567,726
JBrowse link
G Ppargc1b peroxisome proliferative activated receptor, gamma, coactivator 1 beta increases expression ISO Linoleic Acid results in increased expression of PPARGC1B mRNA CTD PMID:23056435 NCBI chr18:61,291,445...61,400,756
Ensembl chr18:61,298,136...61,400,431
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO Linoleic Acid results in increased expression of PTGS2 mRNA
Linoleic Acid inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 mRNA]; Linoleic Acid inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PTGS2 promoter]]; Linoleic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]
CTD PMID:14563831, PMID:18001219 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Rxra retinoid X receptor alpha affects binding
multiple interactions
ISO Linoleic Acid binds to RXRA protein
Linoleic Acid binds to and results in increased activity of RXRA protein
CTD PMID:16258897, PMID:16731579 NCBI chr 2:27,676,445...27,763,319
Ensembl chr 2:27,676,440...27,762,957
JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 increases expression
multiple interactions
ISO Linoleic Acid results in increased expression of SCD mRNA; Linoleic Acid results in increased expression of SCD protein
[Linoleic Acid co-treated with Testosterone] results in increased expression of SCD mRNA
CTD PMID:21457203 NCBI chr19:44,293,676...44,306,864
Ensembl chr19:44,293,674...44,306,864
JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 increases expression EXP Linoleic Acid results in increased expression of SERPINE1 mRNA CTD PMID:17374693 NCBI chr 5:137,061,504...137,072,272
Ensembl chr 5:137,061,504...137,072,268
JBrowse link
G Slc22a6 solute carrier family 22 (organic anion transporter), member 6 decreases activity ISO Linoleic Acid results in decreased activity of SLC22A6 protein CTD PMID:29045746 NCBI chr19:8,617,996...8,628,299
Ensembl chr19:8,618,039...8,628,299
JBrowse link
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 decreases activity ISO Linoleic Acid results in decreased activity of SLC22A8 protein CTD PMID:29045746 NCBI chr19:8,591,254...8,611,835
Ensembl chr19:8,591,254...8,611,835
JBrowse link
G Smad3 SMAD family member 3 decreases abundance EXP SMAD3 protein results in decreased abundance of Linoleic Acid CTD PMID:23034213 NCBI chr 9:63,646,766...63,757,994
Ensembl chr 9:63,646,767...63,757,994
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression ISO Linoleic Acid results in decreased expression of SREBF1 mRNA CTD PMID:14563831 NCBI chr11:60,199,084...60,224,186
Ensembl chr11:60,199,089...60,222,581
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP TGFB1 protein promotes the reaction [Linoleic Acid results in increased activity of LOX protein] CTD PMID:26240151 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
G Tnf tumor necrosis factor decreases response to substance ISO Linoleic Acid results in decreased susceptibility to TNF protein CTD PMID:22683933 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP TRPV1 results in increased susceptibility to [Linoleic Acid co-treated with Freund's Adjuvant] CTD PMID:23006841 NCBI chr11:73,234,149...73,261,322
Ensembl chr11:73,234,292...73,261,242
JBrowse link
G Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) increases expression ISO Linoleic Acid results in increased expression of UCP2 mRNA CTD PMID:11341955 NCBI chr 7:100,493,337...100,499,629
Ensembl chr 7:100,493,337...100,502,020
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO [Linoleic Acid co-treated with Glucose] affects the reaction [Azoxymethane affects the expression of VEGFA protein] CTD PMID:22467055 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369
JBrowse link
G Wnt10b wingless-type MMTV integration site family, member 10B decreases expression EXP Linoleic Acid results in decreased expression of WNT10B mRNA CTD PMID:12021203 NCBI chr15:98,770,712...98,778,206
Ensembl chr15:98,770,712...98,778,150
JBrowse link
linoleic acid hydroperoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) multiple interactions
increases lipidation
ISO Ascorbic Acid promotes the reaction [linoleic acid hydroperoxide results in increased lipidation of AGT protein modified form] CTD PMID:26111765 NCBI chr 8:124,556,587...124,569,706
Ensembl chr 8:124,556,534...124,569,706
JBrowse link
G Cygb cytoglobin increases metabolic processing ISO CYGB protein results in increased metabolism of linoleic acid hydroperoxide CTD PMID:11320098 NCBI chr11:116,645,595...116,654,504
Ensembl chr11:116,645,595...116,654,313
JBrowse link
G Gpx1 glutathione peroxidase 1 increases reduction ISO GPX1 protein results in increased reduction of linoleic acid hydroperoxide CTD PMID:8428933 NCBI chr 9:108,339,080...108,340,342
Ensembl chr 9:108,338,903...108,340,343
JBrowse link
G Gpx2 glutathione peroxidase 2 increases reduction ISO GPX2 protein results in increased reduction of linoleic acid hydroperoxide CTD PMID:8428933 NCBI chr12:76,792,335...76,795,554
Ensembl chr12:76,792,333...76,795,554
JBrowse link
lipoxin A4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl-hydrocarbon receptor multiple interactions EXP AHR affects the reaction [lipoxin A4 results in increased expression of SOCS2 mRNA] CTD PMID:16415877 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions
affects abundance
ISO zileuton inhibits the reaction [ALOX5 protein affects the abundance of lipoxin A4] CTD PMID:15326064 NCBI chr 6:116,410,071...116,461,178
Ensembl chr 6:116,410,077...116,461,178
JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein] CTD PMID:23063943 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO lipoxin A4 inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein] CTD PMID:23063943 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions
decreases expression
ISO lipoxin A4 analog inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA]; lipoxin A4 analog inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL8 protein]; lipoxin A4 inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased secretion of CXCL8 protein]; lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA]; lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL8 protein]
lipoxin A4 analog results in decreased expression of CXCL8 protein
CTD PMID:12235371, PMID:21659618, PMID:23063943, PMID:27663891 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cxcl2 chemokine (C-X-C motif) ligand 2 multiple interactions EXP lipoxin A4 analog inhibits the reaction [TNF protein results in increased secretion of CXCL2 protein] CTD PMID:10377187 NCBI chr 5:90,903,899...90,905,938
Ensembl chr 5:90,903,871...90,905,938
JBrowse link
G Fpr2 formyl peptide receptor 2 multiple interactions
increases activity
ISO [Aspirin results in increased abundance of lipoxin A4] which results in increased expression of FPR2; lipoxin A4 analog binds to and results in decreased activity of FPR2 protein
lipoxin A4 inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of FPR2 mRNA]
lipoxin A4 results in increased activity of FPR2
CTD PMID:12594298, PMID:19597002, PMID:21765620 NCBI chr17:17,887,824...17,893,952
Ensembl chr17:17,887,824...17,893,952
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO lipoxin A4 results in increased expression of HMOX1 mRNA; lipoxin A4 results in increased expression of HMOX1 protein
lipoxin A4 promotes the reaction [NFE2L2 protein binds to HMOX1 enhancer]
CTD PMID:23826208 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Icam1 intercellular adhesion molecule 1 affects response to substance ISO ICAM1 protein affects the susceptibility to lipoxin A4 CTD PMID:7602232 NCBI chr 9:21,015,940...21,028,814
Ensembl chr 9:21,015,985...21,028,817
JBrowse link
G Il1b interleukin 1 beta decreases expression
multiple interactions
decreases secretion
ISO
EXP
lipoxin A4 analog results in decreased expression of IL1B protein
butyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanine inhibits the reaction [lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; butyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanine inhibits the reaction [lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; lipoxin A4 analog inhibits the reaction [TNF protein results in increased secretion of IL1B protein]; lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
lipoxin A4 analog results in decreased secretion of IL1B protein
lipoxin A4 analog inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]; lipoxin A4 analog inhibits the reaction [TNF protein results in increased secretion of IL1B protein]; lipoxin A4 inhibits the reaction [TNF protein results in increased secretion of IL1B protein]
CTD PMID:10377187, PMID:21659618, PMID:21831303 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il4 interleukin 4 increases secretion EXP lipoxin A4 analog results in increased secretion of IL4 protein CTD PMID:10377187 NCBI chr11:53,612,460...53,618,665
Ensembl chr11:53,602,982...53,618,669
JBrowse link
G Il6 interleukin 6 multiple interactions ISO lipoxin A4 inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased secretion of IL6 protein] CTD PMID:27663891 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions EXP lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:21831303 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions EXP lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:21831303 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 affects localization
multiple interactions
ISO lipoxin A4 affects the localization of NFE2L2 protein
lipoxin A4 promotes the reaction [NFE2L2 protein binds to HMOX1 enhancer]
CTD PMID:23826208 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein] CTD PMID:21831303 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP butyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanine inhibits the reaction [lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; butyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanine inhibits the reaction [lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:21831303 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Pdgfb platelet derived growth factor, B polypeptide multiple interactions ISO lipoxin A4 affects the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]; PDGFB protein promotes the reaction [lipoxin A4 results in decreased phosphorylation of PDGFRB protein] CTD PMID:12223454, PMID:20709806 NCBI chr15:79,995,865...80,024,614
Ensembl chr15:79,995,874...80,014,977
JBrowse link
G Pdgfrb platelet derived growth factor receptor, beta polypeptide multiple interactions
decreases phosphorylation
ISO lipoxin A4 affects the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]; lipoxin A4 inhibits the reaction [Leukotriene D4 results in increased activity of PDGFRB protein]; PDGFB protein promotes the reaction [lipoxin A4 results in decreased phosphorylation of PDGFRB protein] CTD PMID:12223454, PMID:20709806 NCBI chr18:61,045,127...61,085,067
Ensembl chr18:61,045,150...61,085,061
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions ISO lipoxin A4 binds to and results in increased activity of PPARG protein CTD PMID:19321784 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Ptafr platelet-activating factor receptor multiple interactions ISO [WEB 2086 binds to and results in decreased activity of PTAFR protein] which results in decreased susceptibility to lipoxin A4 CTD PMID:7602232 NCBI chr 4:132,564,067...132,582,683
Ensembl chr 4:132,564,067...132,582,683
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
affects abundance
ISO [lipoxin A4 co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of PTGS2 protein; Celecoxib inhibits the reaction [PTGS2 protein affects the abundance of lipoxin A4]; lipoxin A4 inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein] CTD PMID:15326064, PMID:21765620 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO
EXP
lipoxin A4 inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]
lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]
CTD PMID:21831303, PMID:23063943 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Selp selectin, platelet affects response to substance ISO SELP protein affects the susceptibility to lipoxin A4 CTD PMID:7602232 NCBI chr 1:164,115,264...164,150,026
Ensembl chr 1:164,115,264...164,150,026
JBrowse link
G Socs2 suppressor of cytokine signaling 2 multiple interactions
increases expression
EXP AHR affects the reaction [lipoxin A4 results in increased expression of SOCS2 mRNA]; butyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanine inhibits the reaction [lipoxin A4 results in increased expression of SOCS2 mRNA]
lipoxin A4 results in increased expression of SOCS2 mRNA; lipoxin A4 results in increased expression of SOCS2 protein
CTD PMID:16415877 NCBI chr10:95,383,903...95,417,321
Ensembl chr10:95,385,362...95,417,180
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
lipoxin A4 analog inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]; lipoxin A4 analog inhibits the reaction [TNF protein results in increased secretion of IL1B protein]; lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; lipoxin A4 inhibits the reaction [TNF protein results in increased secretion of IL1B protein]
butyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanine inhibits the reaction [lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; butyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanine inhibits the reaction [lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; lipoxin A4 analog inhibits the reaction [TNF protein results in increased secretion of CXCL2 protein]; lipoxin A4 analog inhibits the reaction [TNF protein results in increased secretion of IL1B protein]; lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD PMID:10377187, PMID:21575454, PMID:21831303, PMID:23063943 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21538
    chemical entity 21537
      atom 21525
        nonmetal atom 21402
          carbon atom 21111
            organic molecular entity 21111
              lipid 17775
                fatty acid 16580
                  unsaturated fatty acid 934
                    polyunsaturated fatty acid 670
                      omega-6 fatty acid 381
                        (10Z,13Z,16Z)-docosatrienoic acid + 0
                        (10Z,13Z,16Z,19Z,22Z)-octacosapentaenoic acid + 0
                        (11Z,14Z,17Z,20Z)-hexacosatetraenoic acid + 0
                        (12Z,15Z,18Z,21Z,24Z)-triacontapentaenoic acid + 0
                        (13Z,16Z,19Z,22Z)-octacosatetraenoic acid + 0
                        (14Z,17Z,20Z,23Z,26Z)-dotriacontapentaenoic acid + 0
                        (15Z,18Z,21Z,24Z)-triacontatetraenoic acid + 0
                        (16Z,19Z,22Z,25Z,28Z)-tetratriacontapentaenoic acid + 0
                        (17Z,20Z,23Z,26Z)-dotriacontatetraenoic acid + 0
                        (18Z,21Z,24Z,27Z,30Z)-hexatriacontapentaenoic acid + 0
                        (19Z,22Z,25Z,28Z)-tetratriacontatetraenoic acid + 0
                        (20Z,23Z,26Z,29Z,32Z)-octatriacontapentaenoic acid + 0
                        (21Z,24Z,27Z,30Z)-hexatriacontatetraenoic acid + 0
                        (23Z,26Z,29Z,32Z)-octatriacontatetraenoic acid + 0
                        (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoic acid + 4
                        (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoic acid + 0
                        (8E,10E,12Z)-octadecatrienoic acid + 0
                        (8Z,11Z,14Z,17Z,20Z)-hexacosapentaenoic acid + 0
                        (9Z,12Z,15Z,18Z)-tetracosatetraenoic acid + 0
                        all-cis-docosa-7,10,13,16-tetraenoic acid + 2
                        arachidonic acid + 270
                        cis-4-decenoic acid + 0
                        fatty acid 18:3-omega-3omega-6 0
                        fatty acid 20:3-omega-3omega-6 0
                        fatty acid 20:4-omega-6 0
                        fatty acid 22:5-omega-6 0
                        gamma-linolenic acid + 40
                        linoelaidic acid 0
                        linoleic acid + 115
                        lysophosphatidylcholine 0:0/20:3-omega-3omega-6 0
                        lysophosphatidylcholine 18:3-omega-3omega-6 + 0
                        lysophosphatidylcholine 18:3-omega-3omega-6/0:0 0
                        lysophosphatidylcholine 20:3-omega-3omega-6 + 0
                        lysophosphatidylcholine 20:3-omega-3omega-6/0:0 0
                        lysophosphatidylcholine 22:5-omega-6 0
                        lysophosphatidylcholine 22:5-omega-6/0:0 0
                        lysophosphatidylethanolamine 20:3-omega-3omega-6 0
                        lysophosphatidylethanolamine 22:5-omega-6 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 21538
    subatomic particle 21525
      composite particle 21525
        hadron 21525
          baryon 21525
            nucleon 21525
              atomic nucleus 21525
                atom 21525
                  main group element atom 21426
                    p-block element atom 21426
                      carbon group element atom 21213
                        carbon atom 21111
                          organic molecular entity 21111
                            organic group 19548
                              organic divalent group 19538
                                organodiyl group 19538
                                  carbonyl group 19520
                                    carbonyl compound 19520
                                      carboxylic acid 19123
                                        monocarboxylic acid 18394
                                          fatty acid 16580
                                            unsaturated fatty acid 934
                                              polyunsaturated fatty acid 670
                                                essential fatty acid 388
                                                  omega-6 fatty acid 381
                                                    (10Z,13Z,16Z)-docosatrienoic acid + 0
                                                    (10Z,13Z,16Z,19Z,22Z)-octacosapentaenoic acid + 0
                                                    (11Z,14Z,17Z,20Z)-hexacosatetraenoic acid + 0
                                                    (12Z,15Z,18Z,21Z,24Z)-triacontapentaenoic acid + 0
                                                    (13Z,16Z,19Z,22Z)-octacosatetraenoic acid + 0
                                                    (14Z,17Z,20Z,23Z,26Z)-dotriacontapentaenoic acid + 0
                                                    (15Z,18Z,21Z,24Z)-triacontatetraenoic acid + 0
                                                    (16Z,19Z,22Z,25Z,28Z)-tetratriacontapentaenoic acid + 0
                                                    (17Z,20Z,23Z,26Z)-dotriacontatetraenoic acid + 0
                                                    (18Z,21Z,24Z,27Z,30Z)-hexatriacontapentaenoic acid + 0
                                                    (19Z,22Z,25Z,28Z)-tetratriacontatetraenoic acid + 0
                                                    (20Z,23Z,26Z,29Z,32Z)-octatriacontapentaenoic acid + 0
                                                    (21Z,24Z,27Z,30Z)-hexatriacontatetraenoic acid + 0
                                                    (23Z,26Z,29Z,32Z)-octatriacontatetraenoic acid + 0
                                                    (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoic acid + 4
                                                    (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoic acid + 0
                                                    (8E,10E,12Z)-octadecatrienoic acid + 0
                                                    (8Z,11Z,14Z,17Z,20Z)-hexacosapentaenoic acid + 0
                                                    (9Z,12Z,15Z,18Z)-tetracosatetraenoic acid + 0
                                                    all-cis-docosa-7,10,13,16-tetraenoic acid + 2
                                                    arachidonic acid + 270
                                                    cis-4-decenoic acid + 0
                                                    fatty acid 18:3-omega-3omega-6 0
                                                    fatty acid 20:3-omega-3omega-6 0
                                                    fatty acid 20:4-omega-6 0
                                                    fatty acid 22:5-omega-6 0
                                                    gamma-linolenic acid + 40
                                                    linoelaidic acid 0