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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:omega-6 fatty acid
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Accession:CHEBI:36009 term browser browse the term
Definition:A family of polyunsaturated fatty acids that have in common a final carbon-carbon double bond in the n-6 position, i.e., the sixth bond from the methyl end of the fatty acid.
Synonyms:related_synonym: omega-6 fatty acids
 alt_id: MESH:D043371
 xref_mesh: MESH:D043371
 xref: PMID:19035453;   PMID:19136835


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omega-6 fatty acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALG3 ALG3 alpha-1,3- mannosyltransferase decreases expression EXP Fatty Acids, Omega-6 results in decreased expression of ALG3 mRNA CTD PMID:16823509 NCBI chr 3:184,242,301...184,258,301
Ensembl chr 3:184,242,301...184,249,548
JBrowse link
G ATP8A1 ATPase phospholipid transporting 8A1 increases expression EXP Fatty Acids, Omega-6 results in increased expression of ATP8A1 mRNA CTD PMID:16823509 NCBI chr 4:42,408,373...42,657,105
Ensembl chr 4:42,408,373...42,657,105
JBrowse link
G BTN3A1 butyrophilin subfamily 3 member A1 decreases expression EXP Fatty Acids, Omega-6 results in decreased expression of BTN3A1 mRNA CTD PMID:16823509 NCBI chr 6:26,402,269...26,415,216
Ensembl chr 6:26,402,237...26,415,208
JBrowse link
G CCND1 cyclin D1 affects response to substance EXP CCND1 gene SNP affects the susceptibility to Fatty Acids, Omega-6 CTD PMID:15845652 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CD84 CD84 molecule decreases expression EXP Fatty Acids, Omega-6 results in decreased expression of CD84 mRNA CTD PMID:16823509 NCBI chr 1:160,541,098...160,579,515
Ensembl chr 1:160,541,095...160,579,516
JBrowse link
G CPB2 carboxypeptidase B2 increases expression EXP Fatty Acids, Omega-6 results in increased expression of CPB2 mRNA CTD PMID:16823509 NCBI chr13:46,053,066...46,105,033
Ensembl chr13:46,053,186...46,105,033
JBrowse link
G DGKE diacylglycerol kinase epsilon increases expression EXP Fatty Acids, Omega-6 results in increased expression of DGKE mRNA CTD PMID:16823509 NCBI chr17:56,834,131...56,869,567
Ensembl chr17:56,834,107...56,869,567
JBrowse link
G DUSP2 dual specificity phosphatase 2 increases expression EXP Fatty Acids, Omega-6 results in increased expression of DUSP2 mRNA CTD PMID:16823509 NCBI chr 2:96,143,166...96,145,468
Ensembl chr 2:96,143,169...96,145,440
JBrowse link
G EBI3 Epstein-Barr virus induced 3 decreases expression EXP Fatty Acids, Omega-6 results in decreased expression of EBI3 mRNA CTD PMID:16823509 NCBI chr19:4,229,196...4,237,539
Ensembl chr19:4,229,523...4,237,528
JBrowse link
G GARS1 glycyl-tRNA synthetase 1 decreases expression EXP Fatty Acids, Omega-6 results in decreased expression of GARS1 mRNA CTD PMID:16823509 NCBI chr 7:30,594,735...30,634,033
Ensembl chr 7:30,580,533...30,634,033
Ensembl chr 7:30,580,533...30,634,033
JBrowse link
G GJC1 gap junction protein gamma 1 increases expression EXP Fatty Acids, Omega-6 results in increased expression of GJC1 mRNA CTD PMID:16823509 NCBI chr17:44,794,988...44,831,364
Ensembl chr17:44,798,448...44,830,816
JBrowse link
G HS3ST1 heparan sulfate-glucosamine 3-sulfotransferase 1 increases expression EXP Fatty Acids, Omega-6 results in increased expression of HS3ST1 mRNA CTD PMID:16823509 NCBI chr 4:11,393,150...11,434,398
Ensembl chr 4:11,393,150...11,429,564
JBrowse link
G IL1RAP interleukin 1 receptor accessory protein increases expression EXP Fatty Acids, Omega-6 results in increased expression of IL1RAP mRNA CTD PMID:16823509 NCBI chr 3:190,514,085...190,659,750
Ensembl chr 3:190,514,051...190,659,750
JBrowse link
G ITGB4 integrin subunit beta 4 increases expression EXP Fatty Acids, Omega-6 results in increased expression of ITGB4 mRNA CTD PMID:16823509 NCBI chr17:75,721,339...75,757,819
Ensembl chr17:75,721,328...75,757,818
JBrowse link
G KIF4A kinesin family member 4A increases expression EXP Fatty Acids, Omega-6 results in increased expression of KIF4A mRNA CTD PMID:16823509 NCBI chr  X:70,290,104...70,420,886
Ensembl chr  X:70,290,104...70,420,886
JBrowse link
G MSLN mesothelin increases expression EXP Fatty Acids, Omega-6 results in increased expression of MSLN mRNA CTD PMID:16823509 NCBI chr16:760,734...768,865
Ensembl chr16:760,734...768,865
JBrowse link
G NUDCD3 NudC domain containing 3 increases expression EXP Fatty Acids, Omega-6 results in increased expression of NUDCD3 mRNA CTD PMID:16823509 NCBI chr 7:44,379,119...44,490,875
Ensembl chr 7:44,379,119...44,490,658
JBrowse link
G PCDH1 protocadherin 1 increases expression EXP Fatty Acids, Omega-6 results in increased expression of PCDH1 mRNA CTD PMID:16823509 NCBI chr 5:141,850,393...141,878,410
Ensembl chr 5:141,853,111...141,879,246
JBrowse link
G PHKG1 phosphorylase kinase catalytic subunit gamma 1 decreases expression EXP Fatty Acids, Omega-6 results in decreased expression of PHKG1 mRNA CTD PMID:16823509 NCBI chr 7:56,079,927...56,093,450
Ensembl chr 7:56,080,283...56,092,996
JBrowse link
G PSMD11 proteasome 26S subunit, non-ATPase 11 increases expression EXP Fatty Acids, Omega-6 results in increased expression of PSMD11 mRNA CTD PMID:16823509 NCBI chr17:32,444,510...32,483,319
Ensembl chr17:32,444,379...32,483,319
JBrowse link
G PUF60 poly(U) binding splicing factor 60 decreases expression EXP Fatty Acids, Omega-6 results in decreased expression of PUF60 mRNA CTD PMID:16823509 NCBI chr 8:143,816,344...143,829,315
Ensembl chr 8:143,816,344...143,829,352
JBrowse link
G RO60 Ro60, Y RNA binding protein decreases expression EXP Fatty Acids, Omega-6 results in decreased expression of RO60 mRNA CTD PMID:16823509 NCBI chr 1:193,059,454...193,091,777
Ensembl chr 1:193,059,454...193,091,777
Ensembl chr 1:193,059,454...193,091,777
JBrowse link
G SDC4 syndecan 4 increases expression EXP Fatty Acids, Omega-6 results in increased expression of SDC4 mRNA CTD PMID:16823509 NCBI chr20:45,325,288...45,348,424
Ensembl chr20:45,325,288...45,348,424
JBrowse link
G SLC1A6 solute carrier family 1 member 6 decreases expression EXP Fatty Acids, Omega-6 results in decreased expression of SLC1A6 mRNA CTD PMID:16823509 NCBI chr19:14,950,033...15,010,643
Ensembl chr19:14,950,034...15,022,990
JBrowse link
G SLC26A4 solute carrier family 26 member 4 decreases expression EXP Fatty Acids, Omega-6 results in decreased expression of SLC26A4 mRNA CTD PMID:16823509 NCBI chr 7:107,660,828...107,717,809
Ensembl chr 7:107,660,828...107,717,809
JBrowse link
G SOAT1 sterol O-acyltransferase 1 increases expression EXP Fatty Acids, Omega-6 results in increased expression of SOAT1 mRNA CTD PMID:16823509 NCBI chr 1:179,293,719...179,358,680
Ensembl chr 1:179,293,714...179,358,680
JBrowse link
G URB1 URB1 ribosome biogenesis homolog decreases expression EXP Fatty Acids, Omega-6 results in decreased expression of URB1 mRNA CTD PMID:16823509 NCBI chr21:32,311,018...32,393,012
Ensembl chr21:32,311,018...32,393,012
JBrowse link
G VTI1B vesicle transport through interaction with t-SNAREs 1B increases expression EXP Fatty Acids, Omega-6 results in increased expression of VTI1B mRNA CTD PMID:16823509 NCBI chr14:67,647,085...67,674,632
Ensembl chr14:67,647,085...67,674,820
JBrowse link
(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRP C-reactive protein affects expression EXP docosapentaenoic acid affects the expression of CRP protein CTD PMID:22113248 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589
JBrowse link
G PLA2G6 phospholipase A2 group VI multiple interactions ISO docosapentaenoic acid inhibits the reaction [Ethanol results in decreased expression of PLA2G6 protein] CTD PMID:25029343 NCBI chr22:38,111,495...38,181,830
Ensembl chr22:38,111,495...38,214,778
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
ISO docosapentaenoic acid inhibits the reaction [Dimethoate results in increased expression of PTGS2 protein]
docosapentaenoic acid results in decreased expression of PTGS2 protein
CTD PMID:22476691 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G RXRA retinoid X receptor alpha affects binding EXP docosapentaenoic acid binds to RXRA protein CTD PMID:16258897 NCBI chr 9:134,326,455...134,440,585
Ensembl chr 9:134,317,098...134,440,585
JBrowse link
1,2,3-trilinoleoylglycerol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 decreases expression ISO trilinolein results in decreased expression of ABCA1 mRNA CTD PMID:18356535 NCBI chr 9:104,781,006...104,928,232
Ensembl chr 9:104,781,006...104,928,155
JBrowse link
G ABCG5 ATP binding cassette subfamily G member 5 decreases expression ISO trilinolein results in decreased expression of ABCG5 mRNA CTD PMID:18356535 NCBI chr 2:43,806,154...43,838,840
Ensembl chr 2:43,812,472...43,838,865
JBrowse link
G ABCG8 ATP binding cassette subfamily G member 8 decreases expression ISO trilinolein results in decreased expression of ABCG8 mRNA CTD PMID:18356535 NCBI chr 2:43,831,942...43,882,988
Ensembl chr 2:43,831,942...43,882,988
JBrowse link
G CYP27A1 cytochrome P450 family 27 subfamily A member 1 decreases expression ISO trilinolein results in decreased expression of CYP27A1 mRNA CTD PMID:18356535 NCBI chr 2:218,781,733...218,815,293
Ensembl chr 2:218,781,749...218,815,293
JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO trilinolein results in increased expression of HMGCR mRNA CTD PMID:18356535 NCBI chr 5:75,336,334...75,362,116
Ensembl chr 5:75,336,329...75,362,101
JBrowse link
G MTTP microsomal triglyceride transfer protein increases expression ISO trilinolein results in increased expression of MTTP mRNA CTD PMID:18356535 NCBI chr 4:99,564,130...99,623,997
Ensembl chr 4:99,563,761...99,623,999
JBrowse link
G NPC1L1 NPC1 like intracellular cholesterol transporter 1 decreases expression ISO trilinolein results in decreased expression of NPC1L1 mRNA CTD PMID:18356535 NCBI chr 7:44,512,440...44,541,651
Ensembl chr 7:44,512,535...44,541,330
Ensembl chr 7:44,512,535...44,541,330
JBrowse link
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FECH ferrochelatase affects abundance ISO FECH protein affects the abundance of 1-palmitoyl-2-linoleoylphosphatidylcholine CTD PMID:29906468 NCBI chr18:57,544,377...57,586,708
Ensembl chr18:57,544,389...57,586,702
Ensembl chr18:57,544,389...57,586,702
JBrowse link
1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LIPG lipase G, endothelial type increases hydrolysis EXP LIPG protein results in increased hydrolysis of 1-O-hexadecyl-2-arachidonyl-sn-glycero-3-phosphocholine CTD PMID:15953354 NCBI chr18:49,560,699...49,599,185
Ensembl chr18:49,560,699...49,599,185
JBrowse link
1-stearoyl-2-arachidonoyl-sn-glycerol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DAGLA diacylglycerol lipase alpha increases metabolic processing EXP DAGLA protein results in increased metabolism of 1-stearoyl-2-arachidonoylglycerol CTD PMID:18657971 NCBI chr11:61,680,184...61,747,002
Ensembl chr11:61,680,391...61,747,001
JBrowse link
G DAGLB diacylglycerol lipase beta increases metabolic processing EXP DAGLB protein results in increased metabolism of 1-stearoyl-2-arachidonoylglycerol CTD PMID:18657971 NCBI chr 7:6,409,129...6,447,954
Ensembl chr 7:6,409,126...6,484,190
JBrowse link
G DGKE diacylglycerol kinase epsilon increases phosphorylation EXP DGKE protein results in increased phosphorylation of 1-stearoyl-2-arachidonoylglycerol CTD PMID:17455907 NCBI chr17:56,834,131...56,869,567
Ensembl chr17:56,834,107...56,869,567
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha increases expression EXP 1-stearoyl-2-arachidonoylglycerol results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
JBrowse link
G TRPM6 transient receptor potential cation channel subfamily M member 6 multiple interactions EXP TRPM6 protein affects the reaction [1-stearoyl-2-arachidonoylglycerol results in increased transport of Barium]; TRPM6 protein affects the reaction [1-stearoyl-2-arachidonoylglycerol results in increased transport of Calcium] CTD PMID:11988098 NCBI chr 9:74,722,495...74,887,921
Ensembl chr 9:74,722,495...74,888,094
JBrowse link
1-stearoyl-2-linoleoyl-sn-glycerol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LIPC lipase C, hepatic type decreases abundance ISO LIPC gene mutant form results in decreased abundance of 1-stearoyl-2-linoleoyl-sn-glycerol CTD PMID:24777581 NCBI chr15:58,410,457...58,569,844
Ensembl chr15:58,410,569...58,569,844
JBrowse link
G LIPG lipase G, endothelial type decreases abundance ISO LIPG gene mutant form results in decreased abundance of 1-stearoyl-2-linoleoyl-sn-glycerol CTD PMID:24777581 NCBI chr18:49,560,699...49,599,185
Ensembl chr18:49,560,699...49,599,185
JBrowse link
13-HPODE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAT catalase increases expression ISO
EXP
13-hydroperoxy-9,11-octadecadienoic acid results in increased expression of CAT protein CTD PMID:10946007 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CAV1 caveolin 1 increases expression EXP 13-hydroperoxy-9,11-octadecadienoic acid results in increased expression of CAV1 mRNA CTD PMID:27257344 NCBI chr 7:116,525,009...116,561,185
Ensembl chr 7:116,525,001...116,561,184
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions ISO [13-hydroperoxy-9,11-octadecadienoic acid co-treated with 2-chloro-5-nitrobenzanilide] results in increased expression of CCL2 mRNA; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with 2-chloro-5-nitrobenzanilide] results in increased expression of CCL2 protein; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with MK-886] results in increased expression of CCL2 mRNA; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with MK-886] results in increased expression of CCL2 protein CTD PMID:22135674 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G EGR1 early growth response 1 multiple interactions ISO [13-hydroperoxy-9,11-octadecadienoic acid co-treated with 2-chloro-5-nitrobenzanilide] results in increased expression of EGR1 mRNA; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with 2-chloro-5-nitrobenzanilide] results in increased expression of EGR1 protein; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with MK-886] results in increased expression of EGR1 mRNA; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with MK-886] results in increased expression of EGR1 protein CTD PMID:22135674 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha increases expression ISO 13-hydroperoxy-9,11-octadecadienoic acid results in increased expression of PPARA protein CTD PMID:22135674 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma increases expression ISO 13-hydroperoxy-9,11-octadecadienoic acid results in increased expression of PPARG protein CTD PMID:22135674 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
14,15-EET term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme decreases activity ISO 14,15-epoxy-5,8,11-eicosatrienoic acid analog results in decreased activity of ACE protein CTD PMID:27428043 NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380
JBrowse link
G ACE2 angiotensin I converting enzyme 2 multiple interactions ISO 14,15-epoxy-5,8,11-eicosatrienoic acid analog promotes the reaction [REN2 protein results in increased expression of ACE2 protein] CTD PMID:27428043 NCBI chr  X:15,518,197...15,602,158
Ensembl chr  X:15,561,033...15,602,148
JBrowse link
G AGT angiotensinogen multiple interactions
decreases expression
increases cleavage
ISO 14,15-epoxy-5,8,11-eicosatrienoic acid analog inhibits the reaction [REN2 protein results in increased expression of AGT protein modified form]
14,15-epoxy-5,8,11-eicosatrienoic acid analog results in decreased expression of AGT protein modified form
[14,15-epoxy-5,8,11-eicosatrienoic acid analog results in increased cleavage of AGT protein modified form] which results in increased abundance of angiotensin I (1-7)
CTD PMID:27428043 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,702,523...230,714,122
JBrowse link
G AKT1 AKT serine/threonine kinase 1 increases phosphorylation EXP 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of AKT1 protein CTD PMID:16286479 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 increases chemical synthesis EXP CYP2C8 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid CTD PMID:12675279 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 increases chemical synthesis
multiple interactions
EXP CYP2C9 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid
Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid]
CTD PMID:12675279 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases chemical synthesis
multiple interactions
EXP CYP3A4 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid
Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid]
CTD PMID:12675279 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G EPHX2 epoxide hydrolase 2 multiple interactions
increases abundance
ISO [Arsenites results in increased expression of and results in increased activity of EPHX2 protein] which results in decreased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid; [Mercuric Chloride results in increased expression of and results in increased activity of EPHX2 protein] which results in decreased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid
EPHX2 gene mutant form results in increased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid
CTD PMID:19896470 PMID:22680237 PMID:24472606 NCBI chr 8:27,491,143...27,597,559
Ensembl chr 8:27,490,781...27,545,564
JBrowse link
G FGF2 fibroblast growth factor 2 increases expression EXP 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased expression of FGF2 protein CTD PMID:16286479 NCBI chr 4:122,826,708...122,898,236
Ensembl chr 4:122,826,708...122,898,236
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation ISO 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of MAPK1 protein CTD PMID:19464254 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation ISO 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of MAPK3 protein CTD PMID:19464254 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 increases phosphorylation EXP 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of RPS6KB1 protein CTD PMID:16286479 NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions
decreases secretion
EXP 12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [TGFB1 protein results in decreased secretion of 14,15-epoxy-5,8,11-eicosatrienoic acid] CTD PMID:28694203 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
19(S)-HETE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 affects metabolic processing ISO CYP2E1 protein affects the metabolism of 19-hydroxy-5,8,11,14-eicosatetraenoic acid CTD PMID:15205388 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP4A11 cytochrome P450 family 4 subfamily A member 11 increases chemical synthesis EXP CYP4A11 protein results in increased chemical synthesis of 19-hydroxy-5,8,11,14-eicosatetraenoic acid CTD PMID:30259074 NCBI chr 1:46,929,177...46,941,476
Ensembl chr 1:46,929,177...46,941,484
JBrowse link
G CYP4F2 cytochrome P450 family 4 subfamily F member 2 increases chemical synthesis EXP CYP4F2 protein results in increased chemical synthesis of 19-hydroxy-5,8,11,14-eicosatetraenoic acid CTD PMID:30259074 NCBI chr19:15,878,023...15,898,074
Ensembl chr19:15,878,023...15,898,077
JBrowse link
G CYP4F3 cytochrome P450 family 4 subfamily F member 3 increases chemical synthesis EXP CYP4F3 protein alternative form results in increased chemical synthesis of 19-hydroxy-5,8,11,14-eicosatetraenoic acid CTD PMID:30259074 NCBI chr19:15,640,897...15,662,825
Ensembl chr19:15,640,897...15,662,825
JBrowse link
19-HETE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 affects metabolic processing ISO CYP2E1 protein affects the metabolism of 19-hydroxy-5,8,11,14-eicosatetraenoic acid CTD PMID:15205388 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP4A11 cytochrome P450 family 4 subfamily A member 11 increases chemical synthesis EXP CYP4A11 protein results in increased chemical synthesis of 19-hydroxy-5,8,11,14-eicosatetraenoic acid CTD PMID:30259074 NCBI chr 1:46,929,177...46,941,476
Ensembl chr 1:46,929,177...46,941,484
JBrowse link
G CYP4F2 cytochrome P450 family 4 subfamily F member 2 increases chemical synthesis EXP CYP4F2 protein results in increased chemical synthesis of 19-hydroxy-5,8,11,14-eicosatetraenoic acid CTD PMID:30259074 NCBI chr19:15,878,023...15,898,074
Ensembl chr19:15,878,023...15,898,077
JBrowse link
G CYP4F3 cytochrome P450 family 4 subfamily F member 3 increases chemical synthesis EXP CYP4F3 protein alternative form results in increased chemical synthesis of 19-hydroxy-5,8,11,14-eicosatetraenoic acid CTD PMID:30259074 NCBI chr19:15,640,897...15,662,825
Ensembl chr19:15,640,897...15,662,825
JBrowse link
2-arachidonoylglycerol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABHD12 abhydrolase domain containing 12, lysophospholipase increases hydrolysis ISO ABHD12 protein results in increased hydrolysis of glyceryl 2-arachidonate CTD PMID:18096503 NCBI chr20:25,294,743...25,390,835
Ensembl chr20:25,294,742...25,390,835
JBrowse link
G ABHD6 abhydrolase domain containing 6, acylglycerol lipase increases hydrolysis ISO ABHD6 protein results in increased hydrolysis of glyceryl 2-arachidonate CTD PMID:18096503 NCBI chr 3:58,237,532...58,294,736
Ensembl chr 3:58,237,532...58,295,693
JBrowse link
G ACTA2 actin alpha 2, smooth muscle increases expression
multiple interactions
ISO glyceryl 2-arachidonate results in increased expression of ACTA2 mRNA
Acetaldehyde promotes the reaction [glyceryl 2-arachidonate results in increased expression of ACTA2 mRNA]
CTD PMID:21863215 NCBI chr10:88,935,074...88,991,397
Ensembl chr10:88,935,074...88,991,339
JBrowse link
G CCL2 C-C motif chemokine ligand 2 increases expression EXP glyceryl 2-arachidonate results in increased expression of CCL2 protein CTD PMID:15115777 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CES1 carboxylesterase 1 increases hydrolysis
multiple interactions
EXP CES1 protein results in increased hydrolysis of glyceryl 2-arachidonate
[CES1 protein results in increased hydrolysis of glyceryl 2-arachidonate] which results in increased chemical synthesis of Arachidonic Acid
CTD PMID:21049984 NCBI chr16:55,802,851...55,833,127
Ensembl chr16:55,802,851...55,833,337
JBrowse link
G CES2 carboxylesterase 2 increases hydrolysis
multiple interactions
EXP CES2 protein results in increased hydrolysis of glyceryl 2-arachidonate
[CES2 protein results in increased hydrolysis of glyceryl 2-arachidonate] which results in increased chemical synthesis of Arachidonic Acid
CTD PMID:21049984 NCBI chr16:66,934,471...66,945,096
Ensembl chr16:66,934,444...66,945,096
JBrowse link
G CNR1 cannabinoid receptor 1 multiple interactions
increases expression
ISO
EXP
CNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP27A1 mRNA]; CNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP7A1 mRNA]; CNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP7B1 mRNA]; CNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP8B1 mRNA]; CNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; CNR1 protein affects the reaction [glyceryl 2-arachidonate inhibits the reaction [Sulfur Dioxide results in increased expression of PTGS2 protein]]
CNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP27A1 mRNA]; CNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP7A1 mRNA]; CNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP8B1 mRNA]
glyceryl 2-arachidonate results in increased expression of CNR1 mRNA
Acetaldehyde promotes the reaction [glyceryl 2-arachidonate results in increased expression of CNR1 mRNA]; Nitroglycerin affects the reaction [glyceryl 2-arachidonate affects the activity of CNR1 protein]
CTD PMID:12657697 PMID:15899896 PMID:16775503 PMID:21863215 PMID:23894352 PMID:26209559 NCBI chr 6:88,139,864...88,167,349
Ensembl chr 6:88,139,864...88,166,359
JBrowse link
G CNR2 cannabinoid receptor 2 multiple interactions
affects response to substance
EXP [SR 144528 binds to and results in increased activity of CNR2 protein] inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CXCL8 protein]; CNR2 protein affects the reaction [glyceryl 2-arachidonate results in increased expression of CXCL8 protein]; CNR2 protein affects the reaction [glyceryl 2-arachidonate results in increased transport of Calcium]; Pertussis Toxin inhibits the reaction [CNR2 protein affects the reaction [glyceryl 2-arachidonate results in increased transport of Calcium]]; SR 144528 inhibits the reaction [CNR2 protein affects the reaction [glyceryl 2-arachidonate results in increased transport of Calcium]]
CNR2 gene SNP affects the susceptibility to glyceryl 2-arachidonate
CTD PMID:10617657 PMID:15115777 PMID:20124950 NCBI chr 1:23,870,515...23,913,362
Ensembl chr 1:23,870,515...23,913,362
JBrowse link
G CREB3L3 cAMP responsive element binding protein 3 like 3 multiple interactions
increases expression
EXP
ISO
glyceryl 2-arachidonate promotes the reaction [CREB3L3 protein binds to CYP27A1 promoter]; glyceryl 2-arachidonate promotes the reaction [CREB3L3 protein binds to CYP7A1 promoter]; INS protein inhibits the reaction [glyceryl 2-arachidonate promotes the reaction [CREB3L3 protein binds to CYP27A1 promoter]]; INS protein inhibits the reaction [glyceryl 2-arachidonate promotes the reaction [CREB3L3 protein binds to CYP7A1 promoter]]; INS protein inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CREB3L3 mRNA] CTD PMID:23894352 NCBI chr19:4,153,631...4,173,054
Ensembl chr19:4,153,631...4,173,054
JBrowse link
G CRH corticotropin releasing hormone increases abundance ISO CRH protein results in increased abundance of glyceryl 2-arachidonate CTD PMID:26821211 NCBI chr 8:66,176,376...66,178,464
Ensembl chr 8:66,176,376...66,178,464
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases expression
multiple interactions
EXP glyceryl 2-arachidonate analog results in increased expression of CXCL8 protein; glyceryl 2-arachidonate results in increased expression of CXCL8 protein
[SR 144528 binds to and results in increased activity of CNR2 protein] inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CXCL8 protein]; CNR2 protein affects the reaction [glyceryl 2-arachidonate results in increased expression of CXCL8 protein]
CTD PMID:15115777 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYP27A1 cytochrome P450 family 27 subfamily A member 1 multiple interactions
increases expression
EXP
ISO
CNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP27A1 mRNA]; glyceryl 2-arachidonate promotes the reaction [CREB3L3 protein binds to CYP27A1 promoter]; INS protein inhibits the reaction [glyceryl 2-arachidonate promotes the reaction [CREB3L3 protein binds to CYP27A1 promoter]]; INS protein inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP27A1 mRNA] CTD PMID:23894352 NCBI chr 2:218,781,733...218,815,293
Ensembl chr 2:218,781,749...218,815,293
JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 multiple interactions
increases expression
EXP
ISO
CNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP7A1 mRNA]; glyceryl 2-arachidonate promotes the reaction [CREB3L3 protein binds to CYP7A1 promoter]; INS protein inhibits the reaction [glyceryl 2-arachidonate promotes the reaction [CREB3L3 protein binds to CYP7A1 promoter]]; INS protein inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP7A1 mRNA] CTD PMID:23894352 NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163
JBrowse link
G CYP7B1 cytochrome P450 family 7 subfamily B member 1 increases expression
multiple interactions
ISO glyceryl 2-arachidonate results in increased expression of CYP7B1 mRNA
CNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP7B1 mRNA]
CTD PMID:23894352 NCBI chr 8:64,586,575...64,798,737
Ensembl chr 8:64,587,763...64,798,737
JBrowse link
G CYP8B1 cytochrome P450 family 8 subfamily B member 1 increases expression
multiple interactions
EXP
ISO
glyceryl 2-arachidonate results in increased expression of CYP8B1 mRNA
CNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP8B1 mRNA]
CTD PMID:23894352 NCBI chr 3:42,872,192...42,875,879
Ensembl chr 3:42,856,005...42,875,898
JBrowse link
G ESRRG estrogen related receptor gamma increases abundance ISO
EXP
ESRRG protein results in increased abundance of glyceryl 2-arachidonate CTD PMID:31912162 NCBI chr 1:216,503,246...217,137,702
Ensembl chr 1:216,503,246...217,137,755
JBrowse link
G FMR1 FMRP translational regulator 1 multiple interactions ISO [FMR1 gene mutant form results in increased activity of MGLL] which results in increased degradation of glyceryl 2-arachidonate CTD PMID:20393458 NCBI chr  X:147,911,919...147,951,125
Ensembl chr  X:147,911,951...147,951,125
Ensembl chr  X:147,911,951...147,951,125
JBrowse link
G FYN FYN proto-oncogene, Src family tyrosine kinase multiple interactions ISO FYN gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; FYN gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:12657697 NCBI chr 6:111,660,332...111,873,452
Ensembl chr 6:111,660,332...111,873,452
JBrowse link
G IL1B interleukin 1 beta decreases expression ISO glyceryl 2-arachidonate results in decreased expression of IL1B mRNA CTD PMID:16364651 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL2 interleukin 2 multiple interactions EXP glyceryl 2-arachidonate metabolite inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcium Ionophores] results in increased secretion of IL2 protein]; T 0070907 inhibits the reaction [glyceryl 2-arachidonate metabolite inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcium Ionophores] results in increased secretion of IL2 protein]] CTD PMID:21511917 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G IL6 interleukin 6 decreases expression ISO glyceryl 2-arachidonate results in decreased expression of IL6 mRNA CTD PMID:16364651 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G INS insulin multiple interactions EXP INS protein inhibits the reaction [glyceryl 2-arachidonate promotes the reaction [CREB3L3 protein binds to CYP27A1 promoter]]; INS protein inhibits the reaction [glyceryl 2-arachidonate promotes the reaction [CREB3L3 protein binds to CYP7A1 promoter]]; INS protein inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CREB3L3 mRNA]; INS protein inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP27A1 mRNA]; INS protein inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP7A1 mRNA] CTD PMID:23894352 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,341
Ensembl chr11:2,159,779...2,161,341
JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAP2K1 protein]; glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAP2K1 protein; U 0126 inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAP2K1 protein] CTD PMID:12657697 NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,817...66,492,312
Ensembl chr15:66,386,817...66,492,312
JBrowse link
G MAP2K2 mitogen-activated protein kinase kinase 2 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAP2K2 protein]; glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAP2K2 protein; U 0126 inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAP2K2 protein] CTD PMID:12657697 NCBI chr19:4,090,321...4,124,184
Ensembl chr19:4,090,321...4,124,129
Ensembl chr19:4,090,321...4,124,129
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO CNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK1 protein
8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; FYN gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK1 protein; rimonabant inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK1 protein]
CTD PMID:12657697 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO CNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK3 protein
8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; FYN gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK3 protein; rimonabant inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:12657697 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MGLL monoglyceride lipase multiple interactions
increases degradation
increases abundance
increases hydrolysis
ISO [Chlorpyrifos results in decreased activity of MGLL protein] which results in increased abundance of glyceryl 2-arachidonate; JZL 184 inhibits the reaction [MGLL protein results in increased hydrolysis of glyceryl 2-arachidonate]
MGLL protein results in increased degradation of glyceryl 2-arachidonate
[FMR1 gene mutant form results in increased activity of MGLL] which results in increased degradation of glyceryl 2-arachidonate; [JZL 184 results in decreased activity of MGLL protein] which results in increased abundance of glyceryl 2-arachidonate
MGLL gene mutant form results in increased abundance of glyceryl 2-arachidonate
CTD PMID:18096503 PMID:20393458 PMID:21507991 PMID:23761300 PMID:25030704 PMID:26209559 PMID:26642910 NCBI chr 3:127,689,066...127,823,185
Ensembl chr 3:127,689,062...128,052,190
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma affects binding
multiple interactions
increases expression
EXP
ISO
glyceryl 2-arachidonate metabolite binds to PPARG protein
glyceryl 2-arachidonate inhibits the reaction [Sulfur Dioxide results in decreased expression of PPARG protein]; PPARG protein affects the reaction [glyceryl 2-arachidonate inhibits the reaction [Sulfur Dioxide results in increased expression of PTGS2 protein]]; PPARG protein affects the reaction [glyceryl 2-arachidonate inhibits the reaction [Sulfur Dioxide results in increased phosphorylation of RELA protein]]
T 0070907 inhibits the reaction [glyceryl 2-arachidonate metabolite results in increased expression of PPARG mRNA]
CTD PMID:21511917 PMID:26209559 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO [Indomethacin results in decreased expression of PTGS1] which results in increased activity of glyceryl 2-arachidonate CTD PMID:17245358 NCBI chr 9:122,369,906...122,395,703
Ensembl chr 9:122,370,530...122,395,703
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases metabolic processing
multiple interactions
EXP
ISO
PTGS2 protein results in increased metabolism of glyceryl 2-arachidonate
2-chloro-5-nitrobenzanilide inhibits the reaction [glyceryl 2-arachidonate inhibits the reaction [Sulfur Dioxide results in increased expression of PTGS2 protein]]; CNR1 protein affects the reaction [glyceryl 2-arachidonate inhibits the reaction [Sulfur Dioxide results in increased expression of PTGS2 protein]]; glyceryl 2-arachidonate inhibits the reaction [Sulfur Dioxide results in increased expression of PTGS2 protein]; PPARG protein affects the reaction [glyceryl 2-arachidonate inhibits the reaction [Sulfur Dioxide results in increased expression of PTGS2 protein]]; rimonabant inhibits the reaction [glyceryl 2-arachidonate inhibits the reaction [Sulfur Dioxide results in increased expression of PTGS2 protein]]
glyceryl 2-arachidonate inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcium Ionophores] results in increased expression of PTGS2 mRNA]; Ibuprofen inhibits the reaction [PTGS2 protein results in increased metabolism of glyceryl 2-arachidonate]
CTD PMID:18297109 PMID:21511917 PMID:26209559 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [glyceryl 2-arachidonate inhibits the reaction [Sulfur Dioxide results in increased phosphorylation of RELA protein]]; glyceryl 2-arachidonate inhibits the reaction [Sulfur Dioxide results in increased phosphorylation of RELA protein]; PPARG protein affects the reaction [glyceryl 2-arachidonate inhibits the reaction [Sulfur Dioxide results in increased phosphorylation of RELA protein]] CTD PMID:26209559 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G TNF tumor necrosis factor decreases expression
multiple interactions
ISO glyceryl 2-arachidonate results in decreased expression of TNF mRNA
glyceryl 2-arachidonate inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF protein]
CTD PMID:12509806 PMID:16364651 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 multiple interactions
affects response to substance
ISO
EXP
glyceryl 2-arachidonate binds to and results in increased activity of TRPV1 protein
TRPV1 protein affects the susceptibility to glyceryl 2-arachidonate
CTD PMID:18550765 PMID:21949157 NCBI chr17:3,565,446...3,609,411
Ensembl chr17:3,565,444...3,609,411
JBrowse link
20-HETE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLOCK clock circadian regulator affects abundance ISO CLOCK protein affects the abundance of 20-hydroxy-5,8,11,14-eicosatetraenoic acid CTD PMID:22440902 NCBI chr 4:55,427,903...55,547,138
Ensembl chr 4:55,427,903...55,546,909
JBrowse link
G CYP4A11 cytochrome P450 family 4 subfamily A member 11 multiple interactions
increases chemical synthesis
increases secretion
EXP isoliquiritigenin inhibits the reaction [CYP4A11 protein results in increased secretion of 20-hydroxy-5,8,11,14-eicosatetraenoic acid]
CYP4A11 protein results in increased chemical synthesis of 20-hydroxy-5,8,11,14-eicosatetraenoic acid
CTD PMID:23747687 PMID:30259074 NCBI chr 1:46,929,177...46,941,476
Ensembl chr 1:46,929,177...46,941,484
JBrowse link
G CYP4A22 cytochrome P450 family 4 subfamily A member 22 increases chemical synthesis
multiple interactions
ISO CYP4A1 protein results in increased chemical synthesis of 20-hydroxy-5,8,11,14-eicosatetraenoic acid
20-hydroxy-5,8,11,14-eicosatetraenoic acid affects the reaction [CYP4A1 protein affects the susceptibility to Phenylephrine]; 20-hydroxy-5,8,11,14-eicosatetraenoic acid inhibits the reaction [DDMS inhibits the reaction [CYP4A1 protein results in increased susceptibility to Phenylephrine]]
CTD PMID:11124159 PMID:12388396 NCBI chr 1:47,137,441...47,149,738
Ensembl chr 1:47,137,435...47,149,735
JBrowse link
G CYP4F2 cytochrome P450 family 4 subfamily F member 2 increases chemical synthesis EXP CYP4F2 protein results in increased chemical synthesis of 20-hydroxy-5,8,11,14-eicosatetraenoic acid CTD PMID:30259074 NCBI chr19:15,878,023...15,898,074
Ensembl chr19:15,878,023...15,898,077
JBrowse link
G CYP4F3 cytochrome P450 family 4 subfamily F member 3 increases chemical synthesis EXP CYP4F3 protein alternative form results in increased chemical synthesis of 20-hydroxy-5,8,11,14-eicosatetraenoic acid CTD PMID:30259074 NCBI chr19:15,640,897...15,662,825
Ensembl chr19:15,640,897...15,662,825
JBrowse link
G CYP4Z1 cytochrome P450 family 4 subfamily Z member 1 multiple interactions
increases abundance
EXP N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine inhibits the reaction [CYP4Z1 protein results in increased abundance of 20-hydroxy-5,8,11,14-eicosatetraenoic acid] CTD PMID:22841774 NCBI chr 1:47,055,525...47,118,320
Ensembl chr 1:47,067,231...47,118,318
JBrowse link
G NFATC4 nuclear factor of activated T cells 4 multiple interactions
increases localization
EXP
ISO
Cyclosporine inhibits the reaction [20-hydroxy-5,8,11,14-eicosatetraenoic acid results in increased localization of NFATC4 protein]; Tacrolimus inhibits the reaction [20-hydroxy-5,8,11,14-eicosatetraenoic acid results in increased localization of NFATC4 protein] CTD PMID:16055480 NCBI chr14:24,366,911...24,379,604
Ensembl chr14:24,365,673...24,379,604
JBrowse link
G POMC proopiomelanocortin multiple interactions
increases abundance
ISO N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine inhibits the reaction [POMC protein affects the abundance of 20-hydroxy-5,8,11,14-eicosatetraenoic acid]
POMC protein results in increased abundance of 20-hydroxy-5,8,11,14-eicosatetraenoic acid
CTD PMID:18067589 PMID:19458537 NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903
JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation EXP UGT1A1 protein results in increased glucuronidation of 20-hydroxy-5,8,11,14-eicosatetraenoic acid CTD PMID:15231852 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
JBrowse link
G UGT1A4 UDP glucuronosyltransferase family 1 member A4 increases glucuronidation EXP UGT1A4 protein results in increased glucuronidation of 20-hydroxy-5,8,11,14-eicosatetraenoic acid CTD PMID:15231852 NCBI chr 2:233,718,736...233,773,300
Ensembl chr 2:233,718,778...233,773,299
Ensembl chr 2:233,718,778...233,773,299
JBrowse link
G UGT2B7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation EXP UGT2B7 protein results in increased glucuronidation of 20-hydroxy-5,8,11,14-eicosatetraenoic acid CTD PMID:15231852 NCBI chr 4:69,051,375...69,112,987
Ensembl chr 4:69,051,363...69,112,987
JBrowse link
5,6-EET term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions
increases chemical synthesis
EXP Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 5,6-epoxy-8,11,14-eicosatrienoic acid] CTD PMID:12675279 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G EPHX2 epoxide hydrolase 2 increases abundance ISO EPHX2 gene mutant form results in increased abundance of 5,6-epoxy-8,11,14-eicosatrienoic acid CTD PMID:19896470 NCBI chr 8:27,491,143...27,597,559
Ensembl chr 8:27,490,781...27,545,564
JBrowse link
8,9-EET term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 increases chemical synthesis
multiple interactions
EXP CYP2C9 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid
Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid]
CTD PMID:12675279 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases chemical synthesis
multiple interactions
EXP CYP3A4 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid
Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid]
CTD PMID:12675279 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G EPHX1 epoxide hydrolase 1 affects hydrolysis ISO EPHX1 protein affects the hydrolysis of 8,9-epoxyeicosatrienoic acid CTD PMID:28975360 NCBI chr 1:225,810,124...225,845,563
Ensembl chr 1:225,810,092...225,845,563
JBrowse link
G EPHX2 epoxide hydrolase 2 increases abundance ISO EPHX2 gene mutant form results in increased abundance of 8,9-epoxyeicosatrienoic acid CTD PMID:19896470 NCBI chr 8:27,491,143...27,597,559
Ensembl chr 8:27,490,781...27,545,564
JBrowse link
AACOCF3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen multiple interactions ISO arachidonyltrifluoromethane inhibits the reaction [AGT protein results in increased abundance of Epoprostenol] CTD PMID:14613874 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,702,523...230,714,122
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP
ISO
arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CXCL8 mRNA]
arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CXCL15 mRNA]
CTD PMID:18938131 PMID:19063610 PMID:19162293 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions EXP arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:18938131 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 multiple interactions ISO arachidonyltrifluoromethane inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid] CTD PMID:19014389 NCBI chr 8:119,557,085...119,673,404
Ensembl chr 8:119,557,086...119,673,453
JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP arachidonyltrifluoromethane inhibits the reaction [NAD inhibits the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased secretion of IL1B protein]] CTD PMID:29642561 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G INS insulin increases secretion
multiple interactions
EXP arachidonyltrifluoromethane results in increased secretion of INS protein
arachidonyltrifluoromethane inhibits the reaction [Glucose results in increased secretion of INS protein]
CTD PMID:17192482 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,341
Ensembl chr11:2,159,779...2,161,341
JBrowse link
G LEP leptin multiple interactions ISO arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of LEP mRNA] CTD PMID:19063610 NCBI chr 7:128,241,201...128,257,629
Ensembl chr 7:128,241,278...128,257,629
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP arachidonyltrifluoromethane inhibits the reaction [NRG1 protein alternative form results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:15231676 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP arachidonyltrifluoromethane inhibits the reaction [NRG1 protein alternative form results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:15231676 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G NRG1 neuregulin 1 multiple interactions EXP arachidonyltrifluoromethane inhibits the reaction [NRG1 protein alternative form results in increased phosphorylation of and results in increased activity of MAPK1 protein]; arachidonyltrifluoromethane inhibits the reaction [NRG1 protein alternative form results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:15231676 NCBI chr 8:31,639,245...32,774,046
Ensembl chr 8:31,639,222...32,855,666
JBrowse link
G PLA2G4A phospholipase A2 group IVA multiple interactions ISO
EXP
arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of PLA2G4A protein]
arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA]
CTD PMID:18938131 PMID:19063610 PMID:19162293 NCBI chr 1:186,828,949...186,988,981
Ensembl chr 1:186,828,949...186,988,981
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions ISO arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PPARG mRNA] CTD PMID:19063610 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of PTGS2 protein]; arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]; arachidonyltrifluoromethane promotes the reaction [Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]] CTD PMID:18938131 PMID:19063610 PMID:19162293 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G S100A11 S100 calcium binding protein A11 multiple interactions EXP arachidonyltrifluoromethane inhibits the reaction [S100A11 mutant form results in increased susceptibility to Cisplatin]; arachidonyltrifluoromethane inhibits the reaction [S100A11 mutant form results in increased susceptibility to oxaliplatin] CTD PMID:25940438 NCBI chr 1:152,032,506...152,037,004
Ensembl chr 1:152,032,506...152,047,907
JBrowse link
G SOCS3 suppressor of cytokine signaling 3 multiple interactions ISO arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA] CTD PMID:19063610 NCBI chr17:78,356,778...78,360,925
Ensembl chr17:78,356,778...78,360,077
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions EXP arachidonyltrifluoromethane inhibits the reaction [TNF protein results in increased expression of SOD2] CTD PMID:11264281 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP arachidonyltrifluoromethane inhibits the reaction [TNF protein results in increased expression of SOD2] CTD PMID:11264281 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions EXP
ISO
arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA]
arachidonyltrifluoromethane promotes the reaction [Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA]]
CTD PMID:19063610 PMID:19162293 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
all-cis-docosa-7,10,13,16-tetraenoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RXRA retinoid X receptor alpha multiple interactions EXP adrenic acid binds to and results in increased activity of RXRA protein CTD PMID:16258897 NCBI chr 9:134,326,455...134,440,585
Ensembl chr 9:134,317,098...134,440,585
JBrowse link
G TP53 tumor protein p53 multiple interactions ISO [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of adrenic acid CTD PMID:30258081 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
anandamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APP amyloid beta precursor protein decreases response to substance ISO anandamide results in decreased susceptibility to APP protein CTD PMID:22233683 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
G BDKRB1 bradykinin receptor B1 multiple interactions
decreases activity
EXP AM 251 inhibits the reaction [anandamide results in decreased activity of BDKRB1 protein] CTD PMID:19022239 NCBI chr14:96,256,210...96,264,763
Ensembl chr14:96,256,210...96,268,967
JBrowse link
G CD36 CD36 molecule increases expression EXP anandamide results in increased expression of CD36 mRNA; anandamide results in increased expression of CD36 protein CTD PMID:17360047 NCBI chr 7:80,602,207...80,679,277
Ensembl chr 7:80,369,575...80,679,277
JBrowse link
G CNR1 cannabinoid receptor 1 affects activity
affects binding
increases activity
multiple interactions
EXP
ISO
anandamide affects the activity of CNR1 protein
anandamide binds to CNR1 protein
anandamide results in increased activity of CNR1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased activity of CNR1]; CNR1 affects the reaction [TRPV1 affects the susceptibility to anandamide]; Pertussis Toxin inhibits the reaction [anandamide results in increased activity of CNR1]; rimonabant inhibits the reaction [anandamide results in increased activity of CNR1]
[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]; CNR1 gene mutant form inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CNR1 gene mutant form inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; rimonabant inhibits the reaction [[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]]; SR 144528 inhibits the reaction [[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]]
CTD PMID:10871313 PMID:11408034 PMID:11891798 PMID:12657697 PMID:14504685 PMID:15453094 PMID:17557913 PMID:19147270 NCBI chr 6:88,139,864...88,167,349
Ensembl chr 6:88,139,864...88,166,359
JBrowse link
G CNR2 cannabinoid receptor 2 affects activity
affects binding
multiple interactions
EXP
ISO
anandamide affects the activity of CNR2 protein
anandamide binds to CNR2 protein
anandamide binds to and results in increased activity of CNR2 protein; CNR2 affects the reaction [TRPV1 affects the susceptibility to anandamide]
CTD PMID:10617657 PMID:10688601 PMID:15453094 PMID:19147270 NCBI chr 1:23,870,515...23,913,362
Ensembl chr 1:23,870,515...23,913,362
JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases expression EXP anandamide results in increased expression of DDIT3 mRNA CTD PMID:21949157 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions
increases expression
EXP anandamide promotes the reaction [IL1B protein results in increased expression of F3 protein]
anandamide results in increased expression of F3 protein
CTD PMID:27556861 NCBI chr 1:94,529,173...94,541,759
Ensembl chr 1:94,529,173...94,541,759
JBrowse link
G FAAH fatty acid amide hydrolase multiple interactions
increases degradation
affects expression
ISO [nimesulide results in decreased expression of PTGS2] promotes the reaction [FAAH affects the metabolism of anandamide]
[Chlorpyrifos results in decreased activity of FAAH protein] which results in increased abundance of anandamide; [Lipopolysaccharides results in decreased expression of FAAH protein] which results in increased abundance of anandamide; Nitroglycerin promotes the reaction [FAAH protein results in increased degradation of anandamide]
FAAH results in increased degradation of anandamide
anandamide affects the expression of FAAH protein
CTD PMID:11556820 PMID:16131814 PMID:16886060 PMID:19515121 PMID:20702753 PMID:23761300 PMID:26642910 NCBI chr 1:46,394,317...46,413,845
Ensembl chr 1:46,394,317...46,413,848
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO anandamide inhibits the reaction [Nitroglycerin results in increased expression of FOS protein]; capsazepine inhibits the reaction [anandamide results in increased expression of FOS protein]; resiniferatoxin inhibits the reaction [anandamide results in increased expression of FOS protein]
anandamide results in increased expression of FOS; anandamide results in increased expression of FOS protein
CTD PMID:9748483 PMID:15601931 PMID:19515121 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G IFNG interferon gamma multiple interactions EXP anandamide affects the reaction [[Lipopolysaccharides co-treated with IFNG] results in increased secretion of TNF]; anandamide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG] results in increased secretion of IL1B] CTD PMID:12813001 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IGF1 insulin like growth factor 1 increases expression ISO anandamide results in increased expression of IGF1 protein CTD PMID:17307377 NCBI chr12:102,395,860...102,481,839
Ensembl chr12:102,395,874...102,481,744
JBrowse link
G IL12B interleukin 12B multiple interactions ISO [OMDM-1 cpd co-treated with anandamide] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]; anandamide inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein] CTD PMID:15748152 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO
EXP
anandamide inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
anandamide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG] results in increased secretion of IL1B]; anandamide promotes the reaction [IL1B protein results in increased expression of F3 protein]
CTD PMID:12813001 PMID:15748152 PMID:27556861 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G LEP leptin decreases abundance
decreases activity
decreases transport
EXP LEP protein results in decreased abundance of anandamide
LEP protein results in decreased activity of anandamide
LEP protein results in decreased transport of anandamide
CTD PMID:16154199 NCBI chr 7:128,241,201...128,257,629
Ensembl chr 7:128,241,278...128,257,629
JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAP2K1 protein]; anandamide results in increased phosphorylation of and results in increased activity of MAP2K1 protein; U 0126 inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAP2K1 protein] CTD PMID:12657697 NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,817...66,492,312
Ensembl chr15:66,386,817...66,492,312
JBrowse link
G MAP2K2 mitogen-activated protein kinase kinase 2 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAP2K2 protein]; anandamide results in increased phosphorylation of and results in increased activity of MAP2K2 protein; U 0126 inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAP2K2 protein] CTD PMID:12657697 NCBI chr19:4,090,321...4,124,184
Ensembl chr19:4,090,321...4,124,129
Ensembl chr19:4,090,321...4,124,129
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
ISO
EXP
anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein; CNR1 gene mutant form inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]
anandamide results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; AM 251 inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein; Hydrogen Peroxide promotes the reaction [anandamide results in increased phosphorylation of MAPK1 protein]; JTE 907 inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Pertussis Toxin inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; wortmannin inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]
8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein; rimonabant inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]
CTD PMID:12657697 PMID:19477951 PMID:21179406 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
ISO
EXP
anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein; CNR1 gene mutant form inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]
anandamide results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; AM 251 inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein; Hydrogen Peroxide promotes the reaction [anandamide results in increased phosphorylation of MAPK3 protein]; JTE 907 inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Pertussis Toxin inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; wortmannin inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]
8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein; rimonabant inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:12657697 PMID:19477951 PMID:21179406 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MMP1 matrix metallopeptidase 1 increases expression EXP anandamide results in increased expression of MMP1 mRNA CTD PMID:16330497 NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,919...102,798,160
JBrowse link
G MMP3 matrix metallopeptidase 3 increases expression EXP anandamide results in increased expression of MMP3 mRNA CTD PMID:16330497 NCBI chr11:102,835,801...102,843,609
Ensembl chr11:102,835,801...102,843,609
JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions
increases expression
EXP N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [anandamide results in increased expression of MMP9 mRNA] CTD PMID:16330497 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO anandamide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; anandamide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:11891798 PMID:15748152 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions EXP anandamide binds to and results in increased activity of PPARA protein CTD PMID:17906680 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
increases metabolic processing
ISO
EXP
[nimesulide results in decreased expression of PTGS2] which results in increased activity of anandamide
anandamide results in increased expression of PTGS2 mRNA; anandamide results in increased expression of PTGS2 protein
PTGS2 results in increased metabolism of anandamide
[nimesulide results in decreased expression of PTGS2] promotes the reaction [FAAH affects the metabolism of anandamide]
CTD PMID:16330497 PMID:17245358 PMID:20702753 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 increases expression
multiple interactions
EXP anandamide results in increased expression of TIMP1 mRNA
N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [anandamide results in increased expression of TIMP1 mRNA]
CTD PMID:16330497 NCBI chr  X:47,582,408...47,586,789
Ensembl chr  X:47,582,408...47,586,789
JBrowse link
G TNF tumor necrosis factor multiple interactions
increases abundance
ISO
EXP
anandamide inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF protein]
TNF protein results in increased abundance of anandamide
anandamide affects the reaction [[Lipopolysaccharides co-treated with IFNG] results in increased secretion of TNF]
CTD PMID:12509806 PMID:12813001 PMID:20626112 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 multiple interactions
increases response to substance
increases activity
affects response to substance
affects binding
EXP
ISO
3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide inhibits the reaction [anandamide promotes the reaction [TRPV1 protein results in increased uptake of Calcium]]; anandamide binds to and results in increased activity of TRPV1 protein; capsazepine inhibits the reaction [anandamide binds to and results in increased activity of TRPV1 protein]; CNR1 affects the reaction [TRPV1 affects the susceptibility to anandamide]; CNR2 affects the reaction [TRPV1 affects the susceptibility to anandamide]; Egtazic Acid inhibits the reaction [anandamide binds to and results in increased activity of TRPV1 protein]; methyl arachidonylfluorophosphonate promotes the reaction [anandamide binds to and results in increased activity of TRPV1 protein]; N-(2-methyl-3-hydroxyphenyl)-5,8,11,14-eicosatetraenamide inhibits the reaction [anandamide binds to and results in increased activity of TRPV1 protein]; Nitroprusside promotes the reaction [anandamide binds to and results in increased activity of TRPV1 protein]; Phenylmethylsulfonyl Fluoride promotes the reaction [anandamide binds to and results in increased activity of TRPV1 protein]; rimonabant inhibits the reaction [anandamide binds to and results in increased activity of TRPV1 protein]
TRPV1 protein results in increased susceptibility to anandamide
anandamide results in increased activity of TRPV1 protein
3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide inhibits the reaction [anandamide promotes the reaction [TRPV1 protein results in increased uptake of Calcium]]; anandamide binds to and results in increased activity of TRPV1 protein; bisindolylmaleimide inhibits the reaction [anandamide results in increased activity of TRPV1 protein]; Eicosapentaenoic Acid inhibits the reaction [anandamide results in increased activity of TRPV1 protein]; Tetradecanoylphorbol Acetate promotes the reaction [anandamide results in increased activity of TRPV1 protein]
anandamide binds to TRPV1 protein
CTD PMID:11140687 PMID:11278420 PMID:14504685 PMID:15453094 PMID:15601931 PMID:15615864 PMID:17038422 PMID:17913835 PMID:18550765 PMID:21949157 NCBI chr17:3,565,446...3,609,411
Ensembl chr17:3,565,444...3,609,411
JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions ISO anandamide results in decreased expression of and results in decreased secretion of VEGFA protein CTD PMID:15313899 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
arachidonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 multiple interactions
increases degradation
EXP Arachidonic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]; Arachidonic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]]
Arachidonic Acid results in increased degradation of ABCA1 protein
CTD PMID:16118212 NCBI chr 9:104,781,006...104,928,232
Ensembl chr 9:104,781,006...104,928,155
JBrowse link
G ABCB11 ATP binding cassette subfamily B member 11 multiple interactions EXP Arachidonic Acid promotes the reaction [GW 4064 results in increased expression of ABCB11 mRNA] CTD PMID:15307955 NCBI chr 2:168,915,468...169,031,396
Ensembl chr 2:168,915,498...169,031,324
JBrowse link
G ABCD3 ATP binding cassette subfamily D member 3 decreases expression EXP Arachidonic Acid results in decreased expression of ABCD3 mRNA CTD PMID:16704987 NCBI chr 1:94,418,086...94,518,663
Ensembl chr 1:94,418,389...94,518,666
JBrowse link
G ABCG1 ATP binding cassette subfamily G member 1 decreases expression EXP Arachidonic Acid results in decreased expression of ABCG1 mRNA CTD PMID:16730733 NCBI chr21:42,199,689...42,304,387
Ensembl chr21:42,199,689...42,297,244
JBrowse link
G ADARB1 adenosine deaminase RNA specific B1 decreases expression EXP Arachidonic Acid results in decreased expression of ADARB1 mRNA CTD PMID:16704987 NCBI chr21:45,074,578...45,226,563
Ensembl chr21:45,073,853...45,226,560
JBrowse link
G AGT angiotensinogen multiple interactions ISO Eicosapentaenoic Acid inhibits the reaction [AGT protein results in increased metabolism of and results in increased abundance of Arachidonic Acid]; Quinacrine inhibits the reaction [AGT protein results in increased metabolism of and results in increased abundance of Arachidonic Acid] CTD PMID:16257180 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,702,523...230,714,122
JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions EXP AHR affects the reaction [Tetrachlorodibenzodioxin promotes the reaction [PLA2G4A protein results in increased secretion of Arachidonic Acid]] CTD PMID:19162293 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AKT1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
ISO Arachidonic Acid results in increased phosphorylation of AKT1 protein
aristolochic acid I inhibits the reaction [Arachidonic Acid results in increased phosphorylation of AKT1 protein]
CTD PMID:19344371 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G ALOX12 arachidonate 12-lipoxygenase, 12S type affects response to substance
increases metabolic processing
ISO
EXP
ALOX12 protein affects the susceptibility to Arachidonic Acid
ALOX12 protein results in increased metabolism of Arachidonic Acid
CTD PMID:17027136 PMID:19373248 NCBI chr17:6,993,791...7,010,754
Ensembl chr17:6,996,049...7,010,754
JBrowse link
G ALOX12B arachidonate 12-lipoxygenase, 12R type multiple interactions EXP [TP53 protein results in increased expression of ALOX12B mRNA] which results in increased metabolism of Arachidonic Acid CTD PMID:30258081 NCBI chr17:8,072,636...8,087,716
Ensembl chr17:8,072,636...8,087,716
JBrowse link
G ALOX15 arachidonate 15-lipoxygenase affects metabolic processing
multiple interactions
increases metabolic processing
EXP
ISO
ALOX15 protein affects the metabolism of Arachidonic Acid
[ALOX15 protein affects the metabolism of Arachidonic Acid] which affects the susceptibility to Acetylcholine; [ALOX15 protein affects the metabolism of Arachidonic Acid] which results in increased abundance of 11,12,15-trihydroxyeicosatrienoic acid; [ALOX15 protein affects the metabolism of Arachidonic Acid] which results in increased abundance of 11,14,15-trihydroxyeicosa-5,8,12-trienoic acid; [ALOX15 protein affects the metabolism of Arachidonic Acid] which results in increased abundance of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; [ALOX15 protein affects the metabolism of Arachidonic Acid] which results in increased abundance of 15-hydroxy-11,12-epoxyeicosatrienoic acid; [ALOX15 protein affects the metabolism of Arachidonic Acid] which results in increased abundance of 15-hydroxy-5,8,11,13-eicosatetraenoic acid; [ALOX15 protein affects the metabolism of Arachidonic Acid] which results in increased abundance of 6-Ketoprostaglandin F1 alpha; [ALOX15 protein affects the metabolism of Arachidonic Acid] which results in increased abundance of Dinoprostone; ALOX15 protein results in increased metabolism of and affects the susceptibility to Arachidonic Acid
ALOX15 protein results in increased metabolism of Arachidonic Acid
[IL4 protein co-treated with Arachidonic Acid] results in increased activity of ALOX15 protein; [IL4 protein co-treated with Arachidonic Acid] results in increased expression of ALOX15 mRNA
CTD PMID:8305483 PMID:11861792 PMID:21193584 PMID:23872364 NCBI chr17:4,630,919...4,641,678
Ensembl chr17:4,630,919...4,642,294
Ensembl chr17:4,630,919...4,642,294
JBrowse link
G ALOX5 arachidonate 5-lipoxygenase multiple interactions
increases metabolic processing
EXP [sodium arsenite co-treated with Platelet Activating Factor co-treated with Arachidonic Acid] results in increased phosphorylation of and results in increased activity of ALOX5 protein; [Sorbitol co-treated with Calcimycin co-treated with Arachidonic Acid] affects the localization of ALOX5 protein; [TP53 protein results in increased expression of ALOX5 mRNA] which results in increased metabolism of Arachidonic Acid; [zileuton results in decreased activity of ALOX5 protein] which affects the abundance of Arachidonic Acid; [zileuton results in decreased activity of ALOX5 protein] which results in decreased susceptibility to Arachidonic Acid; Arachidonic Acid inhibits the reaction [L 708714 binds to ALOX5 protein]; CJ 13610 inhibits the reaction [ALOX5 protein results in increased metabolism of Arachidonic Acid]; zileuton inhibits the reaction [ALOX5 protein results in increased metabolism of Arachidonic Acid] CTD PMID:7577949 PMID:7592874 PMID:9495842 PMID:10779545 PMID:11698504 PMID:18295198 PMID:30258081 NCBI chr10:45,374,209...45,446,121
Ensembl chr10:45,374,176...45,446,119
JBrowse link
G APOA1 apolipoprotein A1 multiple interactions
decreases expression
EXP Arachidonic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]; Arachidonic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]]
Arachidonic Acid results in decreased expression of APOA1 mRNA
CTD PMID:7983038 PMID:16118212 NCBI chr11:116,835,751...116,837,950
Ensembl chr11:116,835,751...116,837,622
Ensembl chr11:116,835,751...116,837,622
JBrowse link
G APOC1 apolipoprotein C1 decreases expression ISO Arachidonic Acid results in decreased expression of APOC1 mRNA CTD PMID:16623957 NCBI chr19:44,914,325...44,919,346
Ensembl chr19:44,914,247...44,919,349
JBrowse link
G APOE apolipoprotein E multiple interactions
decreases response to substance
EXP
ISO
APOE gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]; Aspirin inhibits the reaction [APOE gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]; dazoxiben inhibits the reaction [APOE gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]; tempol inhibits the reaction [APOE gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]
Aspirin inhibits the reaction [APOE gene mutant form results in decreased susceptibility to Arachidonic Acid]; dazoxiben inhibits the reaction [APOE gene mutant form results in decreased susceptibility to Arachidonic Acid]; Indomethacin promotes the reaction [APOE gene mutant form results in decreased susceptibility to Arachidonic Acid]; tempol inhibits the reaction [APOE gene mutant form results in decreased susceptibility to Arachidonic Acid]
CTD PMID:20530721 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393
JBrowse link
G AQP3 aquaporin 3 (Gill blood group) decreases expression EXP Arachidonic Acid results in decreased expression of AQP3 mRNA CTD PMID:16704987 NCBI chr 9:33,441,154...33,447,596
Ensembl chr 9:33,441,156...33,447,596
JBrowse link
G ARHGDIA Rho GDP dissociation inhibitor alpha increases expression EXP Arachidonic Acid results in increased expression of ARHGDIA mRNA CTD PMID:16704987 NCBI chr17:81,867,719...81,871,337
Ensembl chr17:81,867,721...81,871,378
JBrowse link
G ATF1 activating transcription factor 1 multiple interactions EXP Arachidonic Acid inhibits the reaction [Quercetin results in increased phosphorylation of ATF1 protein] CTD PMID:20551291 NCBI chr12:50,763,682...50,821,162
Ensembl chr12:50,763,710...50,821,162
JBrowse link
G ATF2 activating transcription factor 2 multiple interactions
increases phosphorylation
EXP 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Arachidonic Acid results in increased phosphorylation of ATF2 protein] CTD PMID:19720122 NCBI chr 2:175,072,259...175,168,203
Ensembl chr 2:175,072,250...175,168,382
JBrowse link
G ATF3 activating transcription factor 3 increases expression EXP Arachidonic Acid results in increased expression of ATF3 mRNA CTD PMID:16704987 NCBI chr 1:212,565,407...212,620,777
Ensembl chr 1:212,565,334...212,620,777
JBrowse link
G AVP arginine vasopressin increases abundance ISO AVP protein results in increased abundance of Arachidonic Acid CTD PMID:11356622 NCBI chr20:3,082,556...3,093,521
Ensembl chr20:3,082,556...3,084,724
JBrowse link
G BAD BCL2 associated agonist of cell death multiple interactions EXP [Arachidonic Acid co-treated with Iron] results in increased expression of BAD protein; Plant Extracts inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in increased expression of BAD protein] CTD PMID:30626086 NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704
JBrowse link
G BARX1 BARX homeobox 1 decreases expression ISO Arachidonic Acid results in decreased expression of BARX1 mRNA CTD PMID:16623957 NCBI chr 9:93,951,627...93,955,355
Ensembl chr 9:93,951,627...93,955,355
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions
affects localization
EXP 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Arachidonic Acid affects the localization of BAX protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Arachidonic Acid affects the localization of BAX protein]; [Arachidonic Acid co-treated with Iron] results in increased expression of BAX protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Arachidonic Acid affects the localization of BAX protein]; MAPK14 mutant form inhibits the reaction [Arachidonic Acid affects the localization of BAX protein]; MAPK8 mutant form inhibits the reaction [Arachidonic Acid affects the localization of BAX protein]; Plant Extracts inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [Arachidonic Acid affects the localization of BAX protein] CTD PMID:19540902 PMID:19720122 PMID:30626086 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
multiple interactions
EXP Arachidonic Acid results in decreased expression of BCL2 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2 protein]; [Arachidonic Acid co-treated with Iron] results in decreased expression of BCL2 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2 protein]; MAPK14 mutant form inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2 protein]; MAPK8 mutant form inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2 protein]; Resveratrol inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in decreased expression of BCL2 protein]
CTD PMID:19540902 PMID:19620254 PMID:19720122 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 multiple interactions
decreases expression
EXP 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2L1 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2L1 protein]; [Arachidonic Acid co-treated with Iron] results in decreased expression of BCL2L1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2L1 protein]; Drugs, Chinese Herbal inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in decreased expression of BCL2L1 protein]; MAPK14 mutant form inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2L1 protein]; MAPK8 mutant form inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2L1 protein]; Plant Extracts inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in decreased expression of BCL2L1 protein]; pyrazolanthrone inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2L1 protein]; Resveratrol inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in decreased expression of BCL2L1 protein] CTD PMID:19540902 PMID:19620254 PMID:19720122 PMID:27916511 PMID:30626086 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G BDNF brain derived neurotrophic factor decreases expression EXP Arachidonic Acid results in decreased expression of BDNF mRNA CTD PMID:16704987 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058
JBrowse link
G BID BH3 interacting domain death agonist increases cleavage
multiple interactions
EXP Arachidonic Acid results in increased cleavage of BID protein
FADD protein promotes the reaction [Arachidonic Acid results in increased cleavage of BID protein]
CTD PMID:19720122 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770
JBrowse link
G CASP3 caspase 3 increases activity
multiple interactions
increases degradation
EXP
ISO
Arachidonic Acid results in increased activity of CASP3 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Arachidonic Acid results in increased degradation of CASP3 protein alternative form]; [Arachidonic Acid co-treated with Iron] results in decreased expression of CASP3 protein; [Arachidonic Acid co-treated with Iron] results in increased cleavage of CASP3 protein; [Arachidonic Acid co-treated with Iron] results in increased expression of CASP3 protein modified form; Drugs, Chinese Herbal inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in increased cleavage of CASP3 protein]; FADD protein promotes the reaction [Arachidonic Acid results in increased activity of CASP3 protein]; Plant Extracts inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in increased cleavage of CASP3 protein]; Plant Extracts inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in increased expression of CASP3 protein modified form]; Resveratrol inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in decreased expression of CASP3 protein]
CTD PMID:16704987 PMID:19540902 PMID:19620254 PMID:19720122 PMID:23266427 PMID:27916511 PMID:30626086 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP8 caspase 8 multiple interactions
increases activity
EXP FADD protein promotes the reaction [Arachidonic Acid results in increased activity of CASP8 protein] CTD PMID:19720122 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CASP9 caspase 9 increases activity EXP Arachidonic Acid results in increased activity of CASP9 protein CTD PMID:19540902 PMID:19720122 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase increases activity ISO Arachidonic Acid results in increased activity of CAT protein CTD PMID:7548195 PMID:16982041 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CD40 CD40 molecule multiple interactions EXP Arachidonic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA] CTD PMID:15684433 NCBI chr20:46,118,242...46,129,858
Ensembl chr20:46,118,278...46,129,863
JBrowse link
G CES1 carboxylesterase 1 decreases activity
multiple interactions
EXP Arachidonic Acid results in decreased activity of CES1 protein
[CES1 protein results in increased hydrolysis of glyceryl 2-arachidonate] which results in increased chemical synthesis of Arachidonic Acid
CTD PMID:19761868 PMID:21049984 NCBI chr16:55,802,851...55,833,127
Ensembl chr16:55,802,851...55,833,337
JBrowse link
G CES2 carboxylesterase 2 multiple interactions EXP [CES2 protein results in increased hydrolysis of glyceryl 2-arachidonate] which results in increased chemical synthesis of Arachidonic Acid CTD PMID:21049984 NCBI chr16:66,934,471...66,945,096
Ensembl chr16:66,934,444...66,945,096
JBrowse link
G CNR2 cannabinoid receptor 2 multiple interactions EXP CNR2 protein affects the reaction [Arachidonic Acid results in increased expression of CXCL8 protein] CTD PMID:15115777 NCBI chr 1:23,870,515...23,913,362
Ensembl chr 1:23,870,515...23,913,362
JBrowse link
G COL18A1 collagen type XVIII alpha 1 chain decreases expression EXP Arachidonic Acid results in decreased expression of COL18A1 mRNA CTD PMID:16704987 NCBI chr21:45,405,165...45,513,720
Ensembl chr21:45,405,165...45,513,720
JBrowse link
G CPT1A carnitine palmitoyltransferase 1A increases expression EXP Arachidonic Acid results in increased expression of CPT1A mRNA CTD PMID:15307955 NCBI chr11:68,754,620...68,844,410
Ensembl chr11:68,754,620...68,844,410
JBrowse link
G CREB1 cAMP responsive element binding protein 1 increases phosphorylation
multiple interactions
ISO Arachidonic Acid results in increased phosphorylation of CREB1 protein
Ketoconazole inhibits the reaction [Arachidonic Acid results in increased phosphorylation of CREB1 protein]
CTD PMID:17680988 NCBI chr 2:207,529,943...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G CSK C-terminal Src kinase increases activity
affects localization
EXP Arachidonic Acid results in increased activity of CSK protein
Arachidonic Acid affects the localization of CSK protein
CTD PMID:18388244 NCBI chr15:74,782,080...74,803,197
Ensembl chr15:74,782,057...74,803,198
JBrowse link
G CTDSPL CTD small phosphatase like decreases expression EXP Arachidonic Acid results in decreased expression of CTDSPL mRNA CTD PMID:16704987 NCBI chr 3:37,861,880...37,984,469
Ensembl chr 3:37,861,880...37,984,469
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions
increases secretion
ISO
EXP
Arachidonic Acid promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CXCL15 mRNA]
CNR2 protein affects the reaction [Arachidonic Acid results in increased expression of CXCL8 protein]
Arachidonic Acid results in increased secretion of CXCL8 protein
CTD PMID:15115777 PMID:19063610 PMID:21457203 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYCS cytochrome c, somatic affects localization EXP Arachidonic Acid affects the localization of CYCS protein CTD PMID:19720122 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G CYGB cytoglobin multiple interactions ISO CYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TGFB1 mRNA]; CYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TIMP1 mRNA]; CYGB protein results in decreased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid] CTD PMID:16581302 NCBI chr17:76,527,356...76,557,692
Ensembl chr17:76,527,356...76,551,175
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 affects metabolic processing
multiple interactions
EXP
ISO
CYP1A1 protein affects the metabolism of Arachidonic Acid
Arachidonic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
CTD PMID:15258110 PMID:19063610 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 increases metabolic processing
decreases activity
EXP CYP1A2 protein results in increased metabolism of Arachidonic Acid
Arachidonic Acid results in decreased activity of CYP1A2 protein
CTD PMID:12675279 PMID:16978661 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 affects metabolic processing EXP
ISO
CYP1B1 protein affects the metabolism of Arachidonic Acid CTD PMID:15258110 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G CYP24A1 cytochrome P450 family 24 subfamily A member 1 decreases expression ISO Arachidonic Acid results in decreased expression of CYP24A1 mRNA CTD PMID:16623957 NCBI chr20:54,145,731...54,174,032
Ensembl chr20:54,153,446...54,173,986
JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 increases metabolic processing EXP CYP2B6 protein results in increased metabolism of Arachidonic Acid CTD PMID:12675279 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 decreases activity
increases metabolic processing
multiple interactions
EXP Arachidonic Acid results in decreased activity of CYP2C19 protein
CYP2C19 protein results in increased metabolism of Arachidonic Acid
CYP2C19 gene SNP affects the susceptibility to [Adenosine Diphosphate co-treated with Arachidonic Acid]; CYP2C19 protein results in increased metabolism of [Arachidonic Acid co-treated with NADP]
CTD PMID:12675279 PMID:16978661 PMID:18004210 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
JBrowse link
G CYP2C23P cytochrome P450 family 2 subfamily C member 23, pseudogene multiple interactions ISO CYP2C23 mRNA promotes the reaction [[Arachidonic Acid co-treated with VEGFA protein] results in increased phosphorylation of MAPK1 protein]; CYP2C23 mRNA promotes the reaction [[Arachidonic Acid co-treated with VEGFA protein] results in increased phosphorylation of MAPK3 protein]; CYP2C23 mRNA promotes the reaction [Arachidonic Acid results in increased phosphorylation of MAPK1 protein]; CYP2C23 mRNA promotes the reaction [Arachidonic Acid results in increased phosphorylation of MAPK3 protein] CTD PMID:19464254 NCBI chr10:100,105,754...100,140,151
Ensembl chr10:100,105,754...100,140,151
JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 increases metabolic processing EXP CYP2C8 protein results in increased metabolism of Arachidonic Acid CTD PMID:12675279 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 increases metabolic processing
decreases activity
multiple interactions
EXP CYP2C9 protein results in increased metabolism of Arachidonic Acid
Arachidonic Acid results in decreased activity of CYP2C9 protein
CYP2C9 protein results in increased metabolism of [Arachidonic Acid co-treated with NADP]; Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased metabolism of Arachidonic Acid]
CTD PMID:12675279 PMID:16978661 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 increases metabolic processing EXP CYP2D6 protein results in increased metabolism of Arachidonic Acid CTD PMID:12675279 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,881
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions
affects hydroxylation
increases response to substance
decreases activity
EXP
ISO
[[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT18 protein; [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT8 protein; [Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein; allyl sulfide inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]]; Cadmium Chloride affects the reaction [CYP2E1 protein results in increased susceptibility to Arachidonic Acid]; CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]; CYP2E1 results in increased susceptibility to [Arachidonic Acid co-treated with Zinc Sulfate]; Ditiocarb inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]]; Zinc Sulfate inhibits the reaction [CYP2E1 results in increased susceptibility to Arachidonic Acid]
CYP2E1 protein affects the hydroxylation of Arachidonic Acid
Arachidonic Acid results in decreased activity of CYP2E1 protein
CTD PMID:12086689 PMID:12566070 PMID:15205388 PMID:16978661 PMID:17034788 PMID:21352821 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP2J2 cytochrome P450 family 2 subfamily J member 2 multiple interactions EXP Arachidonic Acid inhibits the reaction [CYP2J2 protein results in decreased methylation of Astemizole] CTD PMID:12386130 NCBI chr 1:59,893,308...59,926,773
Ensembl chr 1:59,893,308...59,926,773
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases metabolic processing
decreases activity
multiple interactions
EXP CYP3A4 protein results in increased metabolism of Arachidonic Acid
Arachidonic Acid results in decreased activity of CYP3A4 protein
Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Arachidonic Acid]
CTD PMID:12675279 PMID:16978661 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G CYP4A11 cytochrome P450 family 4 subfamily A member 11 increases hydroxylation EXP CYP4A11 protein results in increased hydroxylation of Arachidonic Acid CTD PMID:30259074 NCBI chr 1:46,929,177...46,941,476
Ensembl chr 1:46,929,177...46,941,484
JBrowse link
G CYP4F2 cytochrome P450 family 4 subfamily F member 2 multiple interactions
increases hydroxylation
EXP rubiarbonone C inhibits the reaction [CYP4F2 protein results in increased hydroxylation of Arachidonic Acid] CTD PMID:30259074 NCBI chr19:15,878,023...15,898,074
Ensembl chr19:15,878,023...15,898,077
JBrowse link
G CYP4F3 cytochrome P450 family 4 subfamily F member 3 increases hydroxylation
multiple interactions
EXP CYP4F3 protein alternative form results in increased hydroxylation of Arachidonic Acid
rubiarbonone C inhibits the reaction [CYP4F3 protein alternative form results in increased hydroxylation of Arachidonic Acid]
CTD PMID:30259074 NCBI chr19:15,640,897...15,662,825
Ensembl chr19:15,640,897...15,662,825
JBrowse link
G DCT dopachrome tautomerase decreases expression ISO Arachidonic Acid results in decreased expression of DCT mRNA CTD PMID:16623957 NCBI chr13:94,436,811...94,549,406
Ensembl chr13:94,436,811...94,479,682
JBrowse link
G DDIT4 DNA damage inducible transcript 4 increases expression EXP Arachidonic Acid results in increased expression of DDIT4 mRNA CTD PMID:16704987 NCBI chr10:72,273,924...72,276,036
Ensembl chr10:72,273,924...72,276,036
JBrowse link
G DDX24 DEAD-box helicase 24 decreases expression EXP Arachidonic Acid results in decreased expression of DDX24 mRNA CTD PMID:16704987 NCBI chr14:94,048,287...94,081,202
Ensembl chr14:94,048,287...94,081,212
JBrowse link
G DES desmin increases expression ISO Arachidonic Acid results in increased expression of DES mRNA CTD PMID:19089455 NCBI chr 2:219,418,377...219,426,734
Ensembl chr 2:219,418,377...219,426,734
JBrowse link
G DHCR7 7-dehydrocholesterol reductase decreases expression EXP Arachidonic Acid results in decreased expression of DHCR7 mRNA CTD PMID:16704987 NCBI chr11:71,434,411...71,448,393
Ensembl chr11:71,428,193...71,452,868
JBrowse link
G EBP EBP cholestenol delta-isomerase decreases expression EXP Arachidonic Acid results in decreased expression of EBP mRNA CTD PMID:16704987 NCBI chr  X:48,521,808...48,528,716
Ensembl chr  X:48,521,799...48,528,716
JBrowse link
G EGFR epidermal growth factor receptor multiple interactions ISO 5,8,11,14-Eicosatetraynoic Acid inhibits the reaction [Arachidonic Acid results in increased phosphorylation of and results in increased activity of EGFR protein] CTD PMID:15525798 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G EGR1 early growth response 1 increases expression EXP
ISO
Arachidonic Acid results in increased expression of EGR1 mRNA CTD PMID:8764118 PMID:16704987 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
JBrowse link
G EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3 multiple interactions EXP Arachidonic Acid promotes the reaction [Quercetin results in decreased phosphorylation of EIF4EBP3 protein] CTD PMID:20551291 NCBI chr 5:140,547,662...140,549,576
Ensembl chr 5:140,547,662...140,549,576
JBrowse link
G EPHX2 epoxide hydrolase 2 increases metabolic processing ISO EPHX2 protein results in increased metabolism of Arachidonic Acid CTD PMID:26165641 NCBI chr 8:27,491,143...27,597,559
Ensembl chr 8:27,490,781...27,545,564
JBrowse link
G ERG28 ergosterol biosynthesis 28 homolog decreases expression EXP Arachidonic Acid results in decreased expression of ERG28 mRNA CTD PMID:16704987 NCBI chr14:75,649,791...75,660,876
Ensembl chr14:75,649,791...75,660,876
JBrowse link
G F3 coagulation factor III, tissue factor increases expression EXP Arachidonic Acid results in increased expression of F3 protein CTD PMID:27556861 NCBI chr 1:94,529,173...94,541,759
Ensembl chr 1:94,529,173...94,541,759
JBrowse link
G FAAH fatty acid amide hydrolase increases chemical synthesis
multiple interactions
ISO FAAH protein results in increased chemical synthesis of Arachidonic Acid
Nitroglycerin promotes the reaction [FAAH protein results in increased chemical synthesis of Arachidonic Acid]
CTD PMID:19515121 NCBI chr 1:46,394,317...46,413,845
Ensembl chr 1:46,394,317...46,413,848
JBrowse link
G FADD Fas associated via death domain multiple interactions EXP FADD protein promotes the reaction [Arachidonic Acid results in increased activity of CASP3 protein]; FADD protein promotes the reaction [Arachidonic Acid results in increased activity of CASP8 protein]; FADD protein promotes the reaction [Arachidonic Acid results in increased cleavage of BID protein] CTD PMID:19720122 NCBI chr11:70,203,296...70,207,390
Ensembl chr11:70,203,163...70,207,390
Ensembl chr11:70,203,163...70,207,390
JBrowse link
G FADS1 fatty acid desaturase 1 multiple interactions EXP [geraniol results in decreased activity of FADS1 protein] which results in decreased chemical synthesis of Arachidonic Acid CTD PMID:16462894 NCBI chr11:61,799,627...61,817,003
Ensembl chr11:61,799,627...61,829,318
JBrowse link
G FADS2 fatty acid desaturase 2 decreases expression EXP Arachidonic Acid results in decreased expression of FADS2 mRNA CTD PMID:21457203 NCBI chr11:61,816,203...61,867,354
Ensembl chr11:61,792,980...61,867,354
JBrowse link
G FAS Fas cell surface death receptor multiple interactions
increases expression
EXP 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Arachidonic Acid results in increased expression of FAS protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Arachidonic Acid results in increased expression of FAS protein]; Acetylcysteine inhibits the reaction [Arachidonic Acid results in increased expression of FAS protein]; FOS protein affects the reaction [MAP2K1 protein inhibits the reaction [Arachidonic Acid results in increased expression of FAS protein]]; JUN protein affects the reaction [Arachidonic Acid results in increased expression of FAS protein]; MAP2K1 protein inhibits the reaction [Arachidonic Acid results in increased expression of FAS protein]
Arachidonic Acid results in increased expression of FAS mRNA; Arachidonic Acid results in increased expression of FAS protein
CTD PMID:19720122 NCBI chr10:88,968,429...89,017,059
Ensembl chr10:88,990,531...89,017,059
JBrowse link
G FASLG Fas ligand multiple interactions
increases expression
EXP 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Arachidonic Acid results in increased expression of FASLG protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Arachidonic Acid results in increased expression of FASLG protein]; Acetylcysteine inhibits the reaction [Arachidonic Acid results in increased expression of FASLG protein]; FOS protein affects the reaction [MAP2K1 protein inhibits the reaction [Arachidonic Acid results in increased expression of FASLG protein]]; JUN protein affects the reaction [Arachidonic Acid results in increased expression of FASLG protein]; MAP2K1 protein inhibits the reaction [Arachidonic Acid results in increased expression of FASLG protein]
Arachidonic Acid results in increased expression of FASLG mRNA; Arachidonic Acid results in increased expression of FASLG protein
CTD PMID:19720122 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876
JBrowse link
G FASN fatty acid synthase decreases expression ISO Arachidonic Acid results in decreased expression of FASN mRNA CTD PMID:19159447 NCBI chr17:82,078,338...82,098,303
Ensembl chr17:82,078,338...82,098,294
JBrowse link
G FGFR3 fibroblast growth factor receptor 3 decreases expression EXP Arachidonic Acid results in decreased expression of FGFR3 mRNA CTD PMID:16704987 NCBI chr 4:1,793,293...1,808,872
Ensembl chr 4:1,793,293...1,808,872
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
decreases phosphorylation
EXP
ISO
[Arachidonic Acid co-treated with Quercetin co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in decreased expression of FOS protein; Arachidonic Acid inhibits the reaction [Quercetin results in increased expression of FOS protein]; Flurbiprofen inhibits the reaction [Arachidonic Acid results in increased expression of FOS mRNA]; FOS protein affects the reaction [MAP2K1 protein inhibits the reaction [Arachidonic Acid results in increased expression of FAS protein]]; FOS protein affects the reaction [MAP2K1 protein inhibits the reaction [Arachidonic Acid results in increased expression of FASLG protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Arachidonic Acid results in increased expression of FOS mRNA]
Arachidonic Acid results in decreased phosphorylation of FOS protein
CTD PMID:8764118 PMID:10864209 PMID:15878913 PMID:16704987 PMID:19720122 PMID:20551291 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G FOSL1 FOS like 1, AP-1 transcription factor subunit increases expression EXP Arachidonic Acid results in increased expression of FOSL1 mRNA CTD PMID:16704987 NCBI chr11:65,892,049...65,900,545
Ensembl chr11:65,892,049...65,900,573
JBrowse link
G GAP43 growth associated protein 43 increases phosphorylation ISO Arachidonic Acid results in increased phosphorylation of GAP43 protein CTD PMID:9852580 NCBI chr 3:115,623,510...115,721,485
Ensembl chr 3:115,623,324...115,721,490
Ensembl chr 3:115,623,324...115,721,490
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases expression
increases activity
EXP Arachidonic Acid results in increased expression of GCLC mRNA
Arachidonic Acid results in increased activity of GCLC protein
CTD PMID:16704987 PMID:17092368 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit increases expression EXP Arachidonic Acid results in increased expression of GCLM mRNA CTD PMID:16704987 NCBI chr 1:93,885,199...93,910,370
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
G GLRX glutaredoxin affects response to substance ISO GLRX protein affects the susceptibility to Arachidonic Acid CTD PMID:19373248 NCBI chr 5:95,813,849...95,822,726
Ensembl chr 5:95,751,319...95,822,726
JBrowse link
G GNPDA1 glucosamine-6-phosphate deaminase 1 decreases expression EXP Arachidonic Acid results in decreased expression of GNPDA1 mRNA CTD PMID:16704987 NCBI chr 5:142,000,671...142,013,027
Ensembl chr 5:141,991,749...142,013,041
JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO Drugs, Chinese Herbal inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in increased expression of ALT protein]; Plant Extracts inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in increased expression of ALT protein] CTD PMID:27916511 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174
JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions EXP [Iodoacetates results in decreased activity of GPX1 protein] which affects the metabolism of Arachidonic Acid CTD PMID:11115402 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,176...49,358,358
JBrowse link
G GPX4 glutathione peroxidase 4 multiple interactions EXP [Iodoacetates results in decreased activity of GPX4 protein] which affects the metabolism of Arachidonic Acid; Arachidonic Acid promotes the reaction [Sodium Selenite results in increased expression of and results in increased activity of GPX4 protein] CTD PMID:11115402 PMID:14642406 NCBI chr19:1,103,994...1,106,779
Ensembl chr19:1,103,926...1,106,791
JBrowse link
G GSK3B glycogen synthase kinase 3 beta multiple interactions EXP [SB 216763 results in decreased activity of GSK3B protein] results in decreased susceptibility to [Arachidonic Acid co-treated with Iron] CTD PMID:19620254 NCBI chr 3:119,821,321...120,095,823
Ensembl chr 3:119,821,323...120,094,417
Ensembl chr 3:119,821,323...120,094,417
JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression EXP Arachidonic Acid results in decreased expression of HMGCR mRNA CTD PMID:16704987 NCBI chr 5:75,336,334...75,362,116
Ensembl chr 5:75,336,329...75,362,101
JBrowse link
G HMOX1 heme oxygenase 1 increases expression
decreases response to substance
EXP
ISO
Arachidonic Acid results in increased expression of HMOX1 mRNA
HMOX1 protein results in decreased susceptibility to Arachidonic Acid
CTD PMID:15036350 PMID:16704987 PMID:17092368 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G HS2ST1 heparan sulfate 2-O-sulfotransferase 1 decreases expression EXP Arachidonic Acid results in decreased expression of HS2ST1 mRNA CTD PMID:16704987 NCBI chr 1:86,914,635...87,109,982
Ensembl chr 1:86,914,635...87,109,982
JBrowse link
G HSP90AB1 heat shock protein 90 alpha family class B member 1 decreases expression ISO Arachidonic Acid results in decreased expression of HSP90AB1 mRNA CTD PMID:16623957 NCBI chr 6:44,246,194...44,253,883
Ensembl chr 6:44,246,166...44,253,888
JBrowse link
G HSPB11 heat shock protein family B (small) member 11 decreases expression EXP Arachidonic Acid results in decreased expression of HSPB11 mRNA CTD PMID:16704987 NCBI chr 1:53,916,573...53,946,305
Ensembl chr 1:53,916,574...53,945,929
JBrowse link
G HTR1A 5-hydroxytryptamine receptor 1A multiple interactions EXP Arachidonic Acid metabolite inhibits the reaction [HTR1A protein inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]] CTD PMID:11356925 NCBI chr 5:63,957,874...63,962,445
Ensembl chr 5:63,960,356...63,962,507
Ensembl chr 5:63,960,356...63,962,507
JBrowse link
G ID3 inhibitor of DNA binding 3, HLH protein decreases expression EXP Arachidonic Acid results in decreased expression of ID3 mRNA CTD PMID:16704987 NCBI chr 1:23,557,926...23,559,501
Ensembl chr 1:23,557,926...23,559,501
JBrowse link
G IDI1 isopentenyl-diphosphate delta isomerase 1 decreases expression EXP Arachidonic Acid results in decreased expression of IDI1 mRNA CTD PMID:16704987 NCBI chr10:1,039,152...1,056,704
Ensembl chr10:1,039,152...1,049,170
JBrowse link
G IGFBP7 insulin like growth factor binding protein 7 decreases expression EXP Arachidonic Acid results in decreased expression of IGFBP7 mRNA CTD PMID:16704987 NCBI chr 4:57,030,773...57,110,385
Ensembl chr 4:57,030,773...57,110,385
JBrowse link
G IL12B interleukin 12B multiple interactions EXP Arachidonic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA] CTD PMID:15684433 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
JBrowse link
G IL1A interleukin 1 alpha multiple interactions ISO [IL1A protein co-treated with Arachidonic Acid] results in increased abundance of Dinoprostone CTD PMID:11351503 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP [Arachidonic Acid results in increased abundance of Dinoprostone] promotes the reaction [IL1B protein results in increased expression of PTGS2 protein] CTD PMID:11112151 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL4 interleukin 4 multiple interactions EXP [IL4 protein co-treated with Arachidonic Acid] results in increased activity of ALOX15 protein; [IL4 protein co-treated with Arachidonic Acid] results in increased expression of ALOX15 mRNA CTD PMID:11861792 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G IL6 interleukin 6 increases secretion EXP Arachidonic Acid results in increased secretion of IL6 protein CTD PMID:20436887 PMID:21457203 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G ILVBL ilvB acetolactate synthase like decreases expression EXP Arachidonic Acid results in decreased expression of ILVBL mRNA CTD PMID:16704987 NCBI chr19:15,114,982...15,125,786
Ensembl chr19:15,114,984...15,125,786
JBrowse link
G INS insulin increases secretion
multiple interactions
EXP Arachidonic Acid results in increased secretion of INS protein
Arachidonic Acid promotes the reaction [Glucose results in increased secretion of INS protein]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide promotes the reaction [Arachidonic Acid results in increased secretion of INS protein]; phenidone promotes the reaction [Arachidonic Acid results in increased secretion of INS protein]
CTD PMID:17192482 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,341
Ensembl chr11:2,159,779...2,161,341
JBrowse link
G ISL1 ISL LIM homeobox 1 decreases expression EXP Arachidonic Acid results in decreased expression of ISL1 mRNA CTD PMID:16704987 NCBI chr 5:51,383,448...51,394,730
Ensembl chr 5:51,383,448...51,394,730
JBrowse link
G ITGA2B integrin subunit alpha 2b increases expression
multiple interactions
EXP Arachidonic Acid results in increased expression of ITGA2B protein
Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGA2B protein]; Glucose inhibits the reaction [Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGA2B protein]]
CTD PMID:18413191 NCBI chr17:44,372,181...44,389,649
Ensembl chr17:44,372,180...44,389,649
JBrowse link
G ITGA6 integrin subunit alpha 6 increases expression EXP Arachidonic Acid results in increased expression of ITGA6 mRNA CTD PMID:16704987 NCBI chr 2:172,427,336...172,506,459
Ensembl chr 2:172,427,354...172,506,459
JBrowse link
G ITGB3 integrin subunit beta 3 multiple interactions
increases expression
EXP Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGB3 protein]; Glucose inhibits the reaction [Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGB3 protein]]; Quercetin inhibits the reaction [Arachidonic Acid results in increased expression of ITGB3 protein] CTD PMID:18413191 PMID:23249183 NCBI chr17:47,253,827...47,313,743
Ensembl chr17:47,253,846...47,313,735
Ensembl chr17:47,253,846...47,313,735
Ensembl chr17:47,253,846...47,313,735
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
EXP
ISO
Arachidonic Acid results in increased expression of and results in increased phosphorylation of JUN protein; JUN protein affects the reaction [Arachidonic Acid results in increased expression of FAS protein]; JUN protein affects the reaction [Arachidonic Acid results in increased expression of FASLG protein]
Arachidonic Acid results in increased expression of JUN mRNA
CTD PMID:8764118 PMID:16704987 PMID:19720122 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
JBrowse link
G JUNB JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Arachidonic Acid analog results in increased expression of JUNB mRNA]
Arachidonic Acid results in increased expression of JUNB mRNA
CTD PMID:8764118 NCBI chr19:12,791,486...12,793,315
Ensembl chr19:12,791,486...12,793,315
JBrowse link
G KCNK10 potassium two pore domain channel subfamily K member 10 multiple interactions EXP Arachidonic Acid promotes the reaction [KCNK10 protein results in increased transport of Potassium] CTD PMID:16075240 NCBI chr14:88,180,108...88,326,912
Ensembl chr14:88,180,103...88,326,907
JBrowse link
G KCNK2 potassium two pore domain channel subfamily K member 2 multiple interactions EXP Arachidonic Acid promotes the reaction [KCNK2 protein results in increased transport of Potassium] CTD PMID:16075240 NCBI chr 1:215,002,920...215,237,093
Ensembl chr 1:215,005,775...215,237,090
Ensembl chr 1:215,005,775...215,237,090
JBrowse link
G KCNK4 potassium two pore domain channel subfamily K member 4 multiple interactions EXP Arachidonic Acid promotes the reaction [KCNK4 protein results in increased transport of Potassium] CTD PMID:10767409 PMID:16075240 NCBI chr11:64,291,302...64,300,031
Ensembl chr11:64,291,302...64,300,031
JBrowse link
G KLF5 Kruppel like factor 5 increases expression EXP Arachidonic Acid results in increased expression of KLF5 mRNA CTD PMID:16704987 NCBI chr13:73,054,976...73,077,538
Ensembl chr13:73,054,976...73,077,541
JBrowse link
G KNG1 kininogen 1 multiple interactions EXP Arachidonic Acid inhibits the reaction [GW 4064 results in increased expression of KNG1 mRNA] CTD PMID:15307955 NCBI chr 3:186,717,359...186,744,410
Ensembl chr 3:186,717,348...186,744,410
JBrowse link
G KRT18 keratin 18 multiple interactions EXP [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT18 protein CTD PMID:17034788 NCBI chr12:52,948,855...52,952,906
Ensembl chr12:52,948,871...52,952,906
JBrowse link
G KRT8 keratin 8 multiple interactions EXP [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT8 protein CTD PMID:17034788 NCBI chr12:52,897,191...52,949,860
Ensembl chr12:52,897,187...52,949,954
JBrowse link
G LAMP2 lysosomal associated membrane protein 2 decreases expression ISO Arachidonic Acid results in decreased expression of LAMP2 mRNA CTD PMID:16623957 NCBI chr  X:120,426,148...120,469,349
Ensembl chr  X:120,426,148...120,469,365
Ensembl chr  X:120,426,148...120,469,365
JBrowse link
G LDLR low density lipoprotein receptor multiple interactions
decreases response to substance
EXP
ISO
Aspirin inhibits the reaction [LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]; dazoxiben inhibits the reaction [LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]; LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]; tempol inhibits the reaction [LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]
LDLR gene mutant form results in decreased susceptibility to Arachidonic Acid
Aspirin inhibits the reaction [LDLR gene mutant form results in decreased susceptibility to Arachidonic Acid]; dazoxiben inhibits the reaction [LDLR gene mutant form results in decreased susceptibility to Arachidonic Acid]; Indomethacin promotes the reaction [LDLR gene mutant form results in decreased susceptibility to Arachidonic Acid]
CTD PMID:20530721 NCBI chr19:11,089,432...11,133,820
Ensembl chr19:11,089,462...11,133,820
Ensembl chr19:11,089,462...11,133,820
JBrowse link
G LEP leptin multiple interactions ISO Arachidonic Acid promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of LEP mRNA] CTD PMID:19063610 NCBI chr 7:128,241,201...128,257,629
Ensembl chr 7:128,241,278...128,257,629
JBrowse link
G LIPC lipase C, hepatic type decreases abundance
multiple interactions
ISO LIPC gene mutant form results in decreased abundance of Arachidonic Acid
[LIPC gene mutant form co-treated with LIPG gene mutant form] results in decreased abundance of Arachidonic Acid
CTD PMID:24777581 NCBI chr15:58,410,457...58,569,844
Ensembl chr15:58,410,569...58,569,844
JBrowse link
G LIPG lipase G, endothelial type decreases abundance
multiple interactions
ISO LIPG gene mutant form results in decreased abundance of Arachidonic Acid
[LIPC gene mutant form co-treated with LIPG gene mutant form] results in decreased abundance of Arachidonic Acid
CTD PMID:24777581 NCBI chr18:49,560,699...49,599,185
Ensembl chr18:49,560,699...49,599,185
JBrowse link
G LRAT lecithin retinol acyltransferase increases expression ISO Arachidonic Acid results in increased expression of LRAT mRNA CTD PMID:12576510 NCBI chr 4:154,740,838...154,753,120
Ensembl chr 4:154,626,945...154,753,120
JBrowse link
G LSS lanosterol synthase decreases expression EXP Arachidonic Acid results in decreased expression of LSS mRNA CTD PMID:16704987 NCBI chr21:46,188,446...46,228,774
Ensembl chr21:46,188,141...46,228,824
JBrowse link
G LTB4R leukotriene B4 receptor affects response to substance ISO LTB4R1 protein affects the susceptibility to Arachidonic Acid CTD PMID:10934231 NCBI chr14:24,311,502...24,318,036
Ensembl chr14:24,311,450...24,318,036
JBrowse link
G LUC7L3 LUC7 like 3 pre-mRNA splicing factor decreases expression EXP Arachidonic Acid results in decreased expression of LUC7L3 mRNA CTD PMID:16704987 NCBI chr17:50,719,582...50,756,219
Ensembl chr17:50,719,565...50,756,219
JBrowse link
G MAFF MAF bZIP transcription factor F increases expression EXP Arachidonic Acid results in increased expression of MAFF mRNA CTD PMID:16704987 NCBI chr22:38,201,994...38,216,511
Ensembl chr22:38,200,767...38,216,507
JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 multiple interactions EXP FOS protein affects the reaction [MAP2K1 protein inhibits the reaction [Arachidonic Acid results in increased expression of FAS protein]]; FOS protein affects the reaction [MAP2K1 protein inhibits the reaction [Arachidonic Acid results in increased expression of FASLG protein]]; MAP2K1 protein inhibits the reaction [Arachidonic Acid results in increased expression of FAS protein]; MAP2K1 protein inhibits the reaction [Arachidonic Acid results in increased expression of FASLG protein] CTD PMID:19720122 NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,817...66,492,312
Ensembl chr15:66,386,817...66,492,312
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation
affects abundance
multiple interactions
ISO Arachidonic Acid results in increased phosphorylation of MAPK1 protein
MAPK1 protein affects the abundance of Arachidonic Acid
[Arachidonic Acid co-treated with VEGFA protein] results in increased phosphorylation of MAPK1 protein; CYP2C23 mRNA promotes the reaction [[Arachidonic Acid co-treated with VEGFA protein] results in increased phosphorylation of MAPK1 protein]; CYP2C23 mRNA promotes the reaction [Arachidonic Acid results in increased phosphorylation of MAPK1 protein]
CTD PMID:16216387 PMID:19464254 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK14 mitogen-activated protein kinase 14 multiple interactions EXP
ISO
MAPK14 mutant form inhibits the reaction [Arachidonic Acid affects the localization of BAX protein]; MAPK14 mutant form inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2 protein]; MAPK14 mutant form inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2L1 protein]
MAPK14 protein promotes the reaction [2,2',4,6-tetrachlorobiphenyl results in increased secretion of Arachidonic Acid]
CTD PMID:16120751 PMID:19540902 NCBI chr 6:36,027,711...36,122,964
Ensembl chr 6:36,027,677...36,111,236
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
affects abundance
increases phosphorylation
ISO [Arachidonic Acid co-treated with VEGFA protein] results in increased phosphorylation of MAPK3 protein; CYP2C23 mRNA promotes the reaction [[Arachidonic Acid co-treated with VEGFA protein] results in increased phosphorylation of MAPK3 protein]; CYP2C23 mRNA promotes the reaction [Arachidonic Acid results in increased phosphorylation of MAPK3 protein]
MAPK3 protein affects the abundance of Arachidonic Acid
CTD PMID:16216387 PMID:19464254 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP MAPK8 mutant form inhibits the reaction [Arachidonic Acid affects the localization of BAX protein]; MAPK8 mutant form inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2 protein]; MAPK8 mutant form inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2L1 protein] CTD PMID:19540902 NCBI chr10:48,306,673...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MAPT microtubule associated protein tau increases phosphorylation
multiple interactions
EXP Arachidonic Acid results in increased phosphorylation of MAPT protein
Ro 31-8220 inhibits the reaction [Arachidonic Acid results in increased phosphorylation of MAPT protein]
CTD PMID:12605413 NCBI chr17:45,894,538...46,028,334
Ensembl chr17:45,894,551...46,028,334
Ensembl chr17:45,894,551...46,028,334
JBrowse link
G MMP13 matrix metallopeptidase 13 increases secretion
multiple interactions
increases expression
EXP Arachidonic Acid results in increased secretion of MMP13 protein
Isotretinoin inhibits the reaction [Arachidonic Acid results in increased expression of MMP13 mRNA]; Isotretinoin inhibits the reaction [Arachidonic Acid results in increased secretion of MMP13 protein]
CTD PMID:16185265 NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732
JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions
increases expression
increases secretion
EXP Isotretinoin inhibits the reaction [Arachidonic Acid results in increased expression of MMP2 mRNA]; Isotretinoin inhibits the reaction [Arachidonic Acid results in increased secretion of MMP2 protein] CTD PMID:16185265 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G MMP9 matrix metallopeptidase 9 increases expression
multiple interactions
increases secretion
EXP Arachidonic Acid results in increased expression of MMP9 mRNA
Isotretinoin inhibits the reaction [Arachidonic Acid results in increased expression of MMP9 mRNA]; Isotretinoin inhibits the reaction [Arachidonic Acid results in increased secretion of MMP9 protein]
CTD PMID:16185265 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G MPO myeloperoxidase increases secretion
multiple interactions
increases expression
EXP
ISO
Arachidonic Acid results in increased secretion of MPO protein
5-((1,5-bis(4-methoxyphenyl)pyrazol-3-yl)dimethoxymethyl)-2-chlorobenzamide inhibits the reaction [Arachidonic Acid results in increased expression of MPO protein]
CTD PMID:3111576 PMID:9831321 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G MT2A metallothionein 2A multiple interactions EXP Arachidonic Acid promotes the reaction [Zinc Sulfate results in increased expression of MT2A mRNA] CTD PMID:12566070 NCBI chr16:56,608,584...56,609,497
Ensembl chr16:56,608,584...56,609,497
JBrowse link
G MTOR mechanistic target of rapamycin kinase multiple interactions EXP [Quercetin co-treated with Arachidonic Acid] results in decreased phosphorylation of MTOR protein CTD PMID:20551291 NCBI chr 1:11,106,535...11,273,497
Ensembl chr 1:11,106,535...11,262,551
JBrowse link
G NCF1 neutrophil cytosolic factor 1 multiple interactions
increases localization
EXP Adiponectin inhibits the reaction [Arachidonic Acid results in increased localization of NCF1 protein]; Arachidonic Acid affects the reaction [Zymosan analog affects the localization of NCF1 protein] CTD PMID:12101222 PMID:20832062 NCBI chr 7:74,773,962...74,789,376
Ensembl chr 7:74,773,962...74,789,376
JBrowse link
G NCF2 neutrophil cytosolic factor 2 multiple interactions EXP Arachidonic Acid affects the reaction [Zymosan analog affects the localization of NCF2 protein] CTD PMID:12101222 NCBI chr 1:183,555,562...183,590,914
Ensembl chr 1:183,555,563...183,590,876
Ensembl chr 1:183,555,563...183,590,876
JBrowse link
G NOX1 NADPH oxidase 1 multiple interactions EXP Arachidonic Acid results in increased cleavage of and results in increased secretion of NOX1 protein; Cholesterol, LDL affects the reaction [Adiponectin inhibits the reaction [Arachidonic Acid results in increased cleavage of NOX1 protein]] CTD PMID:20832062 NCBI chr  X:100,843,324...100,874,359
Ensembl chr  X:100,843,324...100,874,359
JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 affects binding
multiple interactions
EXP Arachidonic Acid binds to NR1H4 protein
Arachidonic Acid inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]
CTD PMID:15307955 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414
JBrowse link
G NR2F1 nuclear receptor subfamily 2 group F member 1 decreases expression EXP Arachidonic Acid results in decreased expression of NR2F1 mRNA CTD PMID:16704987 NCBI chr 5:93,583,222...93,594,613
Ensembl chr 5:93,583,222...93,594,611
JBrowse link
G NR4A2 nuclear receptor subfamily 4 group A member 2 decreases expression EXP Arachidonic Acid results in decreased expression of NR4A2 mRNA CTD PMID:16704987 NCBI chr 2:156,324,432...156,332,724
Ensembl chr 2:156,324,437...156,342,348
JBrowse link
G NR5A2 nuclear receptor subfamily 5 group A member 2 multiple interactions
decreases chemical synthesis
ISO [NR5A2 gene mutant form results in increased susceptibility to Dietary Fats] which results in decreased abundance of Arachidonic Acid analog
NR5A2 gene mutant form results in decreased chemical synthesis of Arachidonic Acid
CTD PMID:29515023 NCBI chr 1:200,027,710...200,177,415
Ensembl chr 1:200,027,614...200,177,420
JBrowse link
G NRTN neurturin decreases expression EXP Arachidonic Acid results in decreased expression of NRTN mRNA CTD PMID:16704987 NCBI chr19:5,805,067...5,828,324
Ensembl chr19:5,823,802...5,828,324
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions
increases cleavage
EXP
ISO
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Arachidonic Acid results in increased cleavage of PARP1 protein]; [Arachidonic Acid co-treated with Iron] results in increased expression of PARP1 protein modified form; Plant Extracts inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in increased expression of PARP1 protein modified form] CTD PMID:10403056 PMID:19540902 PMID:21132278 PMID:30626086 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G PDE4DIP phosphodiesterase 4D interacting protein decreases expression EXP Arachidonic Acid results in decreased expression of PDE4DIP mRNA CTD PMID:16704987 NCBI chr 1:148,808,198...149,051,277
Ensembl chr 1:148,808,181...149,048,286
JBrowse link
G PDSS2 decaprenyl diphosphate synthase subunit 2 decreases expression EXP Arachidonic Acid results in decreased expression of PDSS2 mRNA CTD PMID:16704987 NCBI chr 6:107,152,557...107,459,681
Ensembl chr 6:107,152,562...107,459,564
JBrowse link
G PHLDA1 pleckstrin homology like domain family A member 1 increases expression EXP Arachidonic Acid results in increased expression of PHLDA1 mRNA CTD PMID:16704987 NCBI chr12:76,025,447...76,031,776
Ensembl chr12:76,025,447...76,033,932
JBrowse link
G PLA2G4A phospholipase A2 group IVA increases expression
multiple interactions
EXP
ISO
Arachidonic Acid results in increased expression of PLA2G4A mRNA; Arachidonic Acid results in increased expression of PLA2G4A protein
PLA2G4A protein promotes the reaction [2,2',4,6-tetrachlorobiphenyl results in increased secretion of Arachidonic Acid]
AHR affects the reaction [Tetrachlorodibenzodioxin promotes the reaction [PLA2G4A protein results in increased secretion of Arachidonic Acid]]; Dinoprostone promotes the reaction [Arachidonic Acid results in increased expression of PLA2G4A mRNA]; Flurbiprofen inhibits the reaction [Arachidonic Acid results in increased expression of PLA2G4A mRNA]
CTD PMID:15878913 PMID:16120751 PMID:19162293 NCBI chr 1:186,828,949...186,988,981
Ensembl chr 1:186,828,949...186,988,981
JBrowse link
G PLA2G5 phospholipase A2 group V multiple interactions EXP PLA2G5 protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Arachidonic Acid] CTD PMID:9495842 NCBI chr 1:20,028,349...20,091,911
Ensembl chr 1:20,028,179...20,091,911
JBrowse link
G PLA2G6 phospholipase A2 group VI multiple interactions ISO PLA2G6 protein promotes the reaction [2,2',4,6-tetrachlorobiphenyl results in increased secretion of Arachidonic Acid] CTD PMID:16120751 NCBI chr22:38,111,495...38,181,830
Ensembl chr22:38,111,495...38,214,778
JBrowse link
G PLAA phospholipase A2 activating protein multiple interactions ISO PLAA protein promotes the reaction [Lipopolysaccharides results in increased abundance of Arachidonic Acid] CTD PMID:11094054 NCBI chr 9:26,903,372...26,947,267
Ensembl chr 9:26,903,372...26,947,242
JBrowse link
G PLIN2 perilipin 2 increases expression ISO Arachidonic Acid results in increased expression of PLIN2 mRNA
Arachidonic Acid results in increased expression of PLIN2 mRNA; Arachidonic Acid results in increased expression of PLIN2 protein
CTD PMID:16489205 NCBI chr 9:19,108,391...19,127,518
Ensembl chr 9:19,108,375...19,149,290
JBrowse link
G PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression EXP Arachidonic Acid results in increased expression of PMAIP1 mRNA CTD PMID:16704987 NCBI chr18:59,899,996...59,904,305
Ensembl chr18:59,899,948...59,904,306
Ensembl chr18:59,899,948...59,904,306
JBrowse link
G PON1 paraoxonase 1 multiple interactions
decreases activity
EXP Arachidonic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; Arachidonic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid]
Arachidonic Acid results in decreased activity of PON1 protein
CTD PMID:15375178 NCBI chr 7:95,297,676...95,324,532
Ensembl chr 7:95,297,676...95,324,532
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha increases expression
multiple interactions
EXP Arachidonic Acid results in increased expression of PPARA mRNA; Arachidonic Acid results in increased expression of PPARA protein
Arachidonic Acid binds to and results in increased activity of PPARA protein
CTD PMID:10403814 PMID:11172467 PMID:15491415 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
G PPARD peroxisome proliferator activated receptor delta increases expression EXP Arachidonic Acid results in increased expression of PPARD mRNA CTD PMID:11172467 NCBI chr 6:35,342,558...35,428,180
Ensembl chr 6:35,342,558...35,428,191
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma decreases expression
increases expression
multiple interactions
EXP
ISO
Arachidonic Acid results in decreased expression of PPARG mRNA; Arachidonic Acid results in decreased expression of PPARG protein
Arachidonic Acid results in increased expression of PPARG protein
Arachidonic Acid promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of PPARG mRNA]
CTD PMID:11172467 PMID:12604186 PMID:19063610 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PPP1CA protein phosphatase 1 catalytic subunit alpha decreases expression ISO Arachidonic Acid results in decreased expression of PPP1CA mRNA CTD PMID:16623957 NCBI chr11:67,398,183...67,401,858
Ensembl chr11:67,398,183...67,421,183
JBrowse link
G PRPF4 pre-mRNA processing factor 4 decreases expression EXP Arachidonic Acid results in decreased expression of PRPF4 mRNA CTD PMID:16704987 NCBI chr 9:113,275,658...113,292,905
Ensembl chr 9:113,275,343...113,292,905
Ensembl chr 9:113,275,343...113,292,905
JBrowse link
G PSAT1 phosphoserine aminotransferase 1 increases expression EXP Arachidonic Acid results in increased expression of PSAT1 mRNA CTD PMID:16704987 NCBI chr 9:78,297,125...78,330,093
Ensembl chr 9:78,297,125...78,330,093
JBrowse link
G PTAFR platelet activating factor receptor multiple interactions ISO [Docosahexaenoic Acids co-treated with Arachidonic Acid] affects the expression of PTAFR mRNA; Arachidonic Acid inhibits the reaction [1-O-hexadecyl-2-N-methylcarbamylphosphatidylcholine results in increased expression of PTAFR mRNA] CTD PMID:17515866 NCBI chr 1:28,147,166...28,193,856
Ensembl chr 1:28,147,166...28,193,936
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 increases activity
increases response to substance
increases metabolic processing
multiple interactions
EXP
ISO
Arachidonic Acid results in increased activity of PTGS1 protein
PTGS1 results in increased susceptibility to Arachidonic Acid
PTGS1 protein alternative form results in increased metabolism of Arachidonic Acid; PTGS1 protein results in increased metabolism of Arachidonic Acid
[[Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to 3,4-Methylenedioxyamphetamine] which results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine; [[Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to Methamphetamine] which results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine; [Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to 3,4-Methylenedioxyamphetamine; [Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to Methamphetamine; [PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of 12-hydroxy-5,8,10-heptadecatrienoic acid; [PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of Thromboxane B2; arzanol inhibits the reaction [[PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of 12-hydroxy-5,8,10-heptadecatrienoic acid]; arzanol inhibits the reaction [[PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of Thromboxane B2]; Aspirin inhibits the reaction [[Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to Methamphetamine]; Aspirin inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein]; DuP 697 inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein]; Resveratrol inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein]; SC 560 inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein]; valerylsalicylate inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein]
CTD PMID:15863457 PMID:16141368 PMID:19751497 PMID:20933508 PMID:21163909 NCBI chr 9:122,369,906...122,395,703
Ensembl chr 9:122,370,530...122,395,703
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
increases metabolic processing
increases response to substance
increases activity
EXP
ISO
[[Arachidonic Acid results in increased activity of PTGS2 protein] which results in increased susceptibility to 3,4-Methylenedioxyamphetamine] which results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine; [[Arachidonic Acid results in increased activity of PTGS2 protein] which results in increased susceptibility to Methamphetamine] which results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine; [ajulemic acid results in increased expression of PTGS2 mRNA] which results in increased secretion of Arachidonic Acid; [Arachidonic Acid results in increased abundance of Dinoprostone] promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]; [Arachidonic Acid results in increased activity of PTGS2 protein] which results in increased susceptibility to 3,4-Methylenedioxyamphetamine; [Arachidonic Acid results in increased activity of PTGS2 protein] which results in increased susceptibility to Methamphetamine; [PTGS2 co-treated with Arachidonic Acid] results in increased expression of VEGFA; Arachidonic Acid inhibits the reaction [5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulfonyl)phenyl-2(5H)-furanone binds to and results in decreased activity of PTGS2 protein]; Arachidonic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Aspirin inhibits the reaction [[Arachidonic Acid results in increased activity of PTGS2 protein] which results in increased susceptibility to Methamphetamine]; Aspirin inhibits the reaction [Arachidonic Acid results in increased activity of PTGS2 protein]; Dinoprostone promotes the reaction [Arachidonic Acid results in increased expression of PTGS2 mRNA]; Flurbiprofen inhibits the reaction [Arachidonic Acid results in increased expression of PTGS2 mRNA]; Ibuprofen inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]; nimesulide inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]
Arachidonic Acid results in increased expression of PTGS2 protein
PTGS2 results in increased susceptibility to Arachidonic Acid
12-HPETE inhibits the reaction [Sodium Salicylate inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]]; 2-methoxybenzoic acid inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]; [Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] which results in increased metabolism of Arachidonic Acid; [nimesulide results in decreased expression of PTGS2] which results in increased abundance of Arachidonic Acid; [PTGS2 protein results in increased abundance of prostaglandin G2] inhibits the reaction [Sodium Salicylate inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]]; Arachidonic Acid affects the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]; Benzoic Acid inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]; Eugenol inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] which results in increased metabolism of Arachidonic Acid]; Sodium Salicylate inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]
Arachidonic Acid results in increased expression of PTGS2 mRNA; Arachidonic Acid results in increased expression of PTGS2 protein
CTD PMID:9013627 PMID:9146894 PMID:11112151 PMID:12538810 PMID:12757841 PMID:12821125 PMID:15684433 PMID:15863457 PMID:15878913 PMID:17092368 PMID:17624748 PMID:18297109 PMID:18388244 PMID:18840450 PMID:19063610 PMID:21163909 PMID:22476691 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G PTP4A1 protein tyrosine phosphatase 4A1 increases expression EXP Arachidonic Acid results in increased expression of PTP4A1 mRNA CTD PMID:16704987 NCBI chr 6:63,516,440...63,583,588
Ensembl chr 6:63,521,746...63,583,436
JBrowse link
G RAPGEF2 Rap guanine nucleotide exchange factor 2 increases expression EXP Arachidonic Acid results in increased expression of RAPGEF2 mRNA CTD PMID:16704987 NCBI chr 4:159,104,051...159,360,169
Ensembl chr 4:159,103,013...159,360,174
JBrowse link
G RETN resistin decreases expression EXP Arachidonic Acid results in decreased expression of RETN mRNA CTD PMID:15949695 NCBI chr19:7,669,049...7,670,455
Ensembl chr19:7,669,049...7,670,455
JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 multiple interactions EXP Arachidonic Acid promotes the reaction [Quercetin results in decreased phosphorylation of RPS6KB1 protein] CTD PMID:20551291 NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574
JBrowse link
G RXRA retinoid X receptor alpha affects binding EXP Arachidonic Acid binds to RXRA protein CTD PMID:16258897 NCBI chr 9:134,326,455...134,440,585
Ensembl chr 9:134,317,098...134,440,585
JBrowse link
G SCD stearoyl-CoA desaturase increases expression EXP Arachidonic Acid results in increased expression of SCD mRNA CTD PMID:21457203 NCBI chr10:100,347,233...100,364,826
Ensembl chr10:100,347,233...100,364,826
JBrowse link
G SELP selectin P increases expression
multiple interactions
EXP Arachidonic Acid results in increased expression of SELP protein
Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of SELP protein]; Glucose inhibits the reaction [Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of SELP protein]]; Quercetin inhibits the reaction [Arachidonic Acid results in increased expression of SELP protein]
CTD PMID:17543677 PMID:18413191 PMID:23249183 NCBI chr 1:169,588,849...169,630,125
Ensembl chr 1:169,588,849...169,630,193
JBrowse link
G SERPINB2 serpin family B member 2 increases expression EXP Arachidonic Acid results in increased expression of SERPINB2 mRNA CTD PMID:18388244 NCBI chr18:63,887,705...63,903,890
Ensembl chr18:63,871,692...63,903,888
JBrowse link
G SKP2 S-phase kinase associated protein 2 decreases expression EXP Arachidonic Acid results in decreased expression of SKP2 mRNA CTD PMID:16704987 NCBI chr 5:36,152,067...36,184,319
Ensembl chr 5:36,151,989...36,184,319
JBrowse link
G SLC4A2 solute carrier family 4 member 2 increases expression ISO Arachidonic Acid results in increased expression of SLC4A2 mRNA CTD PMID:16623957 NCBI chr 7:151,058,200...151,076,527
Ensembl chr 7:151,057,210...151,076,526
JBrowse link
G SLC7A11 solute carrier family 7 member 11 increases expression EXP Arachidonic Acid results in increased expression of SLC7A11 mRNA CTD PMID:16704987 NCBI chr 4:138,164,097...138,242,349
Ensembl chr 4:138,164,097...138,242,349
JBrowse link
G SNAI2 snail family transcriptional repressor 2 increases expression EXP Arachidonic Acid results in increased expression of SNAI2 mRNA CTD PMID:16704987 NCBI chr 8:48,917,598...48,921,429
Ensembl chr 8:48,917,598...48,921,740
JBrowse link
G SOCS3 suppressor of cytokine signaling 3 multiple interactions ISO Arachidonic Acid promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA] CTD PMID:19063610 NCBI chr17:78,356,778...78,360,925
Ensembl chr17:78,356,778...78,360,077
JBrowse link
G SOD1 superoxide dismutase 1 decreases activity
increases activity
multiple interactions
ISO Arachidonic Acid results in decreased activity of SOD1 protein
Arachidonic Acid results in increased activity of SOD1 protein
2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [Arachidonic Acid results in decreased activity of SOD1 protein]; Indomethacin inhibits the reaction [Arachidonic Acid results in decreased activity of SOD1 protein]
CTD PMID:16982041 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,622...31,668,931
Ensembl chr21:31,659,622...31,668,931
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions
increases activity
increases expression
EXP
ISO
[Arachidonic Acid results in increased abundance of Reactive Oxygen Species] which results in increased expression of SOD2; Acetylcysteine inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 protein]; Arachidonic Acid results in increased expression of and results in increased activity of SOD2 protein; calphostin C inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 mRNA]; calphostin C inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 protein]; Dactinomycin inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 mRNA]; Indomethacin inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 mRNA]; Indomethacin inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 protein]; Masoprocol inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 mRNA]; Masoprocol inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 protein]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 mRNA]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 protein]; Phenols inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 protein]
Arachidonic Acid results in increased activity of SOD2 protein
2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [Arachidonic Acid results in increased activity of SOD2 protein]; Indomethacin inhibits the reaction [Arachidonic Acid results in increased activity of SOD2 protein]
CTD PMID:12031898 PMID:16982041 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SOX9 SRY-box transcription factor 9 decreases expression EXP Arachidonic Acid results in decreased expression of SOX9 mRNA CTD PMID:16704987 NCBI chr17:72,121,020...72,126,416
Ensembl chr17:72,121,020...72,126,416
JBrowse link
G SPARC secreted protein acidic and cysteine rich decreases expression EXP Arachidonic Acid results in decreased expression of SPARC mRNA CTD PMID:16704987 NCBI chr 5:151,661,096...151,686,915
Ensembl chr 5:151,661,096...151,686,975
JBrowse link
G SPAST spastin decreases expression EXP Arachidonic Acid results in decreased expression of SPAST mRNA CTD PMID:16704987 NCBI chr 2:32,063,551...32,157,637
Ensembl chr 2:32,063,556...32,157,637
Ensembl chr 2:32,063,556...32,157,637
JBrowse link
G SQSTM1 sequestosome 1 increases expression EXP Arachidonic Acid results in increased expression of SQSTM1 mRNA CTD PMID:16704987 NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078
JBrowse link
G SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 decreases expression EXP Arachidonic Acid results in decreased expression of SRGAP2 mRNA CTD PMID:16704987 NCBI chr 1:206,203,541...206,464,436
Ensembl chr 1:206,203,345...206,464,443
JBrowse link
G SSR2 signal sequence receptor subunit 2 decreases expression ISO Arachidonic Acid results in decreased expression of SSR2 mRNA CTD PMID:16623957 NCBI chr 1:156,009,048...156,020,951
Ensembl chr 1:156,009,048...156,020,951
JBrowse link
G STAR steroidogenic acute regulatory protein multiple interactions
increases expression
ISO Arachidonic Acid inhibits the reaction [Dimethoate results in decreased expression of STAR protein]
Arachidonic Acid results in increased expression of STAR protein
CTD PMID:22476691 NCBI chr 8:38,142,700...38,150,952
Ensembl chr 8:38,142,700...38,150,992
JBrowse link
G STC2 stanniocalcin 2 increases expression EXP Arachidonic Acid results in increased expression of STC2 mRNA CTD PMID:16704987 NCBI chr 5:173,314,723...173,328,414
Ensembl chr 5:173,314,713...173,329,503
JBrowse link
G STK11 serine/threonine kinase 11 multiple interactions EXP STK11 protein affects the reaction [resveratrol results in decreased susceptibility to [Arachidonic Acid co-treated with Iron]] CTD PMID:19620254 NCBI chr19:1,205,778...1,228,431
Ensembl chr19:1,177,558...1,228,431
Ensembl chr19:1,177,558...1,228,431
JBrowse link
G TFEB transcription factor EB decreases expression ISO Arachidonic Acid results in decreased expression of TFEB mRNA CTD PMID:16623957 NCBI chr 6:41,683,978...41,736,223
Ensembl chr 6:41,683,978...41,736,259
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO [ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TGFB1 mRNA; CYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TGFB1 mRNA] CTD PMID:16581302 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G THRSP thyroid hormone responsive decreases expression
multiple interactions
ISO Arachidonic Acid results in decreased expression of THRSP mRNA
Flurbiprofen inhibits the reaction [Arachidonic Acid results in decreased expression of THRSP mRNA]
CTD PMID:10357836 NCBI chr11:78,063,861...78,068,351
Ensembl chr11:78,063,861...78,068,351
JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO [ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TIMP1 mRNA; CYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TIMP1 mRNA] CTD PMID:16581302 NCBI chr  X:47,582,408...47,586,789
Ensembl chr  X:47,582,408...47,586,789
JBrowse link
G TLR4 toll like receptor 4 multiple interactions ISO [Docosahexaenoic Acids co-treated with Arachidonic Acid] affects the expression of TLR4 mRNA; Arachidonic Acid inhibits the reaction [1-O-hexadecyl-2-N-methylcarbamylphosphatidylcholine results in increased expression of TLR4 mRNA] CTD PMID:17515866 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735
JBrowse link
G TNF tumor necrosis factor multiple interactions
increases abundance
increases secretion
EXP
ISO
Arachidonic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Butylated Hydroxyanisole inhibits the reaction [TNF protein results in increased secretion of Arachidonic Acid]
TNF protein results in increased abundance of Arachidonic Acid
Butylated Hydroxyanisole inhibits the reaction [TNF protein results in increased abundance of Arachidonic Acid]; TNFRSF1A protein affects the reaction [Butylated Hydroxyanisole inhibits the reaction [TNF protein results in increased abundance of Arachidonic Acid]]
CTD PMID:1515551 PMID:10588948 PMID:15684433 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFRSF12A TNF receptor superfamily member 12A increases expression EXP Arachidonic Acid results in increased expression of TNFRSF12A mRNA CTD PMID:16704987 NCBI chr16:3,020,368...3,022,383
Ensembl chr16:3,018,445...3,022,383
JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A multiple interactions ISO TNFRSF1A protein affects the reaction [Butylated Hydroxyanisole inhibits the reaction [TNF protein results in increased abundance of Arachidonic Acid]] CTD PMID:10588948 NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114
JBrowse link
G TNS3 tensin 3 decreases expression EXP Arachidonic Acid results in decreased expression of TNS3 mRNA CTD PMID:16704987 NCBI chr 7:47,275,154...47,582,553
Ensembl chr 7:47,275,154...47,582,558
JBrowse link
G TOP2A DNA topoisomerase II alpha decreases expression EXP Arachidonic Acid results in decreased expression of TOP2A mRNA CTD PMID:16704987 NCBI chr17:40,388,525...40,417,902
Ensembl chr17:40,388,525...40,417,896
JBrowse link
G TP53 tumor protein p53 multiple interactions EXP
ISO
[TP53 protein results in increased expression of ALOX12B mRNA] which results in increased metabolism of Arachidonic Acid; [TP53 protein results in increased expression of ALOX5 mRNA] which results in increased metabolism of Arachidonic Acid
[TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of Arachidonic Acid
CTD PMID:30258081 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TRPA1 transient receptor potential cation channel subfamily A member 1 increases activity
multiple interactions
ISO Arachidonic Acid results in increased activity of TRPA1 protein
Ruthenium Red inhibits the reaction [Arachidonic Acid results in increased activity of TRPA1 protein]
CTD PMID:15046718 NCBI chr 8:72,021,250...72,094,885
Ensembl chr 8:72,019,917...72,075,584
JBrowse link
G TRPC4 transient receptor potential cation channel subfamily C member 4 multiple interactions EXP TRPC4 protein affects the reaction [Arachidonic Acid results in increased transport of Calcium] CTD PMID:11830588 NCBI chr13:37,632,063...37,869,772
Ensembl chr13:37,636,636...37,870,425
Ensembl chr13:37,636,636...37,870,425
JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 multiple interactions ISO [Arachidonic Acid co-treated with Phorbol 12,13-Dibutyrate] results in increased activity of TRPV1 protein CTD PMID:17038422 NCBI chr17:3,565,446...3,609,411
Ensembl chr17:3,565,444...3,609,411
JBrowse link
G TRPV4 transient receptor potential cation channel subfamily V member 4 increases activity EXP Arachidonic Acid results in increased activity of TRPV4 protein CTD PMID:20956320 NCBI chr12:109,783,087...109,833,398
Ensembl chr12:109,783,087...109,833,406
Ensembl chr12:109,783,087...109,833,406
JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation EXP UGT1A1 protein results in increased glucuronidation of Arachidonic Acid CTD PMID:15231852 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
JBrowse link
G UGT1A10 UDP glucuronosyltransferase family 1 member A10 increases glucuronidation EXP UGT1A10 protein results in increased glucuronidation of Arachidonic Acid CTD PMID:15231852 NCBI chr 2:233,636,477...233,773,305
Ensembl chr 2:233,636,454...233,773,305
JBrowse link
G UGT1A3 UDP glucuronosyltransferase family 1 member A3 increases glucuronidation EXP UGT1A3 protein results in increased glucuronidation of Arachidonic Acid CTD PMID:15231852 NCBI chr 2:233,729,042...233,773,300
Ensembl chr 2:233,729,108...233,773,299
JBrowse link
G UGT1A4 UDP glucuronosyltransferase family 1 member A4 increases glucuronidation EXP UGT1A4 protein results in increased glucuronidation of Arachidonic Acid CTD PMID:15231852 NCBI chr 2:233,718,736...233,773,300
Ensembl chr 2:233,718,778...233,773,299
Ensembl chr 2:233,718,778...233,773,299
JBrowse link
G UGT1A9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation EXP UGT1A9 protein results in increased glucuronidation of Arachidonic Acid CTD PMID:15231852 NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300
JBrowse link
G UGT2B7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation EXP UGT2B7 protein results in increased glucuronidation of Arachidonic Acid CTD PMID:15231852 NCBI chr 4:69,051,375...69,112,987
Ensembl chr 4:69,051,363...69,112,987
JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions
increases expression
EXP
ISO
[PTGS2 co-treated with Arachidonic Acid] results in increased expression of VEGFA
[Arachidonic Acid co-treated with VEGFA protein] results in increased phosphorylation of MAPK1 protein; [Arachidonic Acid co-treated with VEGFA protein] results in increased phosphorylation of MAPK3 protein; CYP2C23 mRNA promotes the reaction [[Arachidonic Acid co-treated with VEGFA protein] results in increased phosphorylation of MAPK1 protein]; CYP2C23 mRNA promotes the reaction [[Arachidonic Acid co-treated with VEGFA protein] results in increased phosphorylation of MAPK3 protein]
Arachidonic Acid results in increased expression of VEGFA mRNA
CTD PMID:12821125 PMID:18388244 PMID:19464254 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
G YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta increases expression EXP Arachidonic Acid results in increased expression of YWHAZ mRNA CTD PMID:16704987 NCBI chr 8:100,916,523...100,954,068
Ensembl chr 8:100,916,523...100,953,388
JBrowse link
G ZBED2 zinc finger BED-type containing 2 decreases expression EXP Arachidonic Acid results in decreased expression of ZBED2 mRNA CTD PMID:16704987 NCBI chr 3:111,592,900...111,595,346
Ensembl chr 3:111,592,900...111,595,346
JBrowse link
G ZFP36 ZFP36 ring finger protein increases expression ISO Arachidonic Acid results in increased expression of ZFP36 mRNA CTD PMID:8764118 NCBI chr19:39,406,847...39,409,407
Ensembl chr19:39,406,847...39,409,412
JBrowse link
arachidonoyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPARA peroxisome proliferator activated receptor alpha multiple interactions EXP arachidonyl-coenzyme A binds to and results in increased activity of PPARA protein CTD PMID:11139385 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
cholesteryl arachidonate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LIPC lipase C, hepatic type multiple interactions ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl arachidonate CTD PMID:24777581 NCBI chr15:58,410,457...58,569,844
Ensembl chr15:58,410,569...58,569,844
JBrowse link
G LIPG lipase G, endothelial type multiple interactions
decreases abundance
ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl arachidonate
LIPG gene mutant form results in decreased abundance of cholesteryl arachidonate
CTD PMID:24777581 NCBI chr18:49,560,699...49,599,185
Ensembl chr18:49,560,699...49,599,185
JBrowse link
cholesteryl linoleate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LIPC lipase C, hepatic type multiple interactions ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl linoleate CTD PMID:24777581 NCBI chr15:58,410,457...58,569,844
Ensembl chr15:58,410,569...58,569,844
JBrowse link
G LIPG lipase G, endothelial type multiple interactions
affects abundance
ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl linoleate
LIPG gene mutant form affects the abundance of cholesteryl linoleate
CTD PMID:24777581 NCBI chr18:49,560,699...49,599,185
Ensembl chr18:49,560,699...49,599,185
JBrowse link
gamma-linolenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1C1 aldo-keto reductase family 1 member C1 increases expression EXP gamma-Linolenic Acid results in increased expression of AKR1C1 mRNA CTD PMID:20664735 NCBI chr10:4,963,415...4,983,283
Ensembl chr10:4,963,253...4,983,283
JBrowse link
G AKR1C4 aldo-keto reductase family 1 member C4 increases expression EXP gamma-Linolenic Acid results in increased expression of AKR1C4 mRNA CTD PMID:20664735 NCBI chr10:5,196,837...5,218,949
Ensembl chr10:5,195,462...5,218,949
JBrowse link
G APOH apolipoprotein H decreases expression EXP gamma-Linolenic Acid results in decreased expression of APOH mRNA CTD PMID:20664735 NCBI chr17:66,212,033...66,229,415
Ensembl chr17:66,212,033...66,256,525
JBrowse link
G AR androgen receptor multiple interactions EXP gamma-Linolenic Acid inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G ASAH1 N-acylsphingosine amidohydrolase 1 increases expression EXP gamma-Linolenic Acid results in increased expression of ASAH1 mRNA CTD PMID:20664735 NCBI chr 8:18,055,992...18,084,961
Ensembl chr 8:18,055,992...18,084,998
JBrowse link
G CASP3 caspase 3 increases activity EXP gamma-Linolenic Acid results in increased activity of CASP3 protein CTD PMID:16857180 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CCNA2 cyclin A2 decreases expression EXP gamma-Linolenic Acid results in decreased expression of CCNA2 protein CTD PMID:15318936 NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883
JBrowse link
G CCNE1 cyclin E1 decreases expression EXP gamma-Linolenic Acid results in decreased expression of CCNE1 protein CTD PMID:15318936 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312
JBrowse link
G CDK1 cyclin dependent kinase 1 decreases expression EXP gamma-Linolenic Acid results in decreased expression of CDK1 protein CTD PMID:15318936 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852
JBrowse link
G CLDN5 claudin 5 multiple interactions EXP [gamma-Linolenic Acid co-treated with Iodine co-treated with Selenium] results in increased expression of and results in increased localization of CLDN5 protein; [gamma-Linolenic Acid co-treated with Iodine] results in increased expression of and results in increased localization of CLDN5 protein; [Selenium co-treated with gamma-Linolenic Acid] results in increased expression of and results in increased localization of CLDN5 protein; gamma-Linolenic Acid results in increased expression of and results in increased localization of CLDN5 protein CTD PMID:16514648 NCBI chr22:19,523,024...19,525,337
Ensembl chr22:19,523,024...19,527,545
JBrowse link
G CLTA clathrin light chain A increases expression EXP gamma-Linolenic Acid results in increased expression of CLTA mRNA CTD PMID:20664735 NCBI chr 9:36,190,855...36,212,059
Ensembl chr 9:36,190,856...36,304,781
JBrowse link
G FTH1 ferritin heavy chain 1 increases expression EXP gamma-Linolenic Acid results in increased expression of FTH1 mRNA CTD PMID:20664735 NCBI chr11:61,964,285...61,967,634
Ensembl chr11:61,959,718...61,967,634
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases activity
increases expression
EXP gamma-Linolenic Acid results in increased activity of GCLC protein
gamma-Linolenic Acid results in increased expression of GCLC mRNA
CTD PMID:17092368 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GRK5 G protein-coupled receptor kinase 5 increases expression EXP gamma-Linolenic Acid results in increased expression of GRK5 mRNA CTD PMID:20664735 NCBI chr10:119,207,571...119,459,745
Ensembl chr10:119,207,571...119,459,745
JBrowse link
G H2AC6 H2A clustered histone 6 decreases expression EXP gamma-Linolenic Acid results in decreased expression of H2AC6 mRNA CTD PMID:20664735 NCBI chr 6:26,124,172...26,124,690
Ensembl chr 6:26,124,145...26,139,116
JBrowse link
G HEXB hexosaminidase subunit beta increases expression EXP gamma-Linolenic Acid results in increased expression of HEXB mRNA CTD PMID:20664735 NCBI chr 5:74,640,023...74,721,288
Ensembl chr 5:74,640,023...74,722,647
JBrowse link
G HMOX1 heme oxygenase 1 increases expression EXP gamma-Linolenic Acid results in increased expression of HMOX1 mRNA; gamma-Linolenic Acid results in increased expression of HMOX1 protein CTD PMID:17092368 PMID:20664735 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G IL2 interleukin 2 affects expression EXP gamma-Linolenic Acid affects the expression of IL2 protein CTD PMID:9415022 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G JUNB JunB proto-oncogene, AP-1 transcription factor subunit decreases expression EXP gamma-Linolenic Acid results in decreased expression of JUNB protein CTD PMID:15318936 NCBI chr19:12,791,486...12,793,315
Ensembl chr19:12,791,486...12,793,315
JBrowse link
G KYNU kynureninase decreases expression EXP gamma-Linolenic Acid results in decreased expression of KYNU mRNA CTD PMID:20664735 NCBI chr 2:142,877,664...143,055,833
Ensembl chr 2:142,877,657...143,055,833
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 decreases expression EXP gamma-Linolenic Acid results in decreased expression of MAPK3 protein CTD PMID:15318936 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MMP11 matrix metallopeptidase 11 decreases expression EXP gamma-Linolenic Acid results in decreased expression of MMP11 mRNA CTD PMID:20664735 NCBI chr22:23,772,849...23,784,316
Ensembl chr22:23,768,226...23,784,316
JBrowse link
G MT1G metallothionein 1G increases expression EXP gamma-Linolenic Acid results in increased expression of MT1G mRNA CTD PMID:20664735 NCBI chr16:56,666,730...56,668,065
Ensembl chr16:56,666,731...56,668,065
Ensembl chr16:56,666,731...56,668,065
JBrowse link
G MT1L metallothionein 1L, pseudogene increases expression EXP gamma-Linolenic Acid results in increased expression of MT1L mRNA CTD PMID:20664735 NCBI chr16:56,617,461...56,618,818
Ensembl chr16:56,617,476...56,618,818
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor decreases expression EXP gamma-Linolenic Acid results in decreased expression of MYC protein CTD PMID:15318936 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G OCLN occludin multiple interactions EXP [gamma-Linolenic Acid co-treated with Iodine co-treated with Selenium] results in increased expression of and results in increased localization of OCLN protein; [gamma-Linolenic Acid co-treated with Iodine] results in increased expression of and results in increased localization of OCLN protein; [Selenium co-treated with gamma-Linolenic Acid] results in increased expression of and results in increased localization of OCLN protein; gamma-Linolenic Acid results in increased expression of and results in increased localization of OCLN protein CTD PMID:16514648 NCBI chr 5:69,492,547...69,558,104
Ensembl chr 5:69,492,292...69,558,104
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage ISO gamma-Linolenic Acid results in increased cleavage of PARP1 protein CTD PMID:10403056 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G PCNA proliferating cell nuclear antigen decreases expression EXP gamma-Linolenic Acid results in decreased expression of PCNA mRNA CTD PMID:20664735 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
JBrowse link
G PDLIM1 PDZ and LIM domain 1 decreases expression EXP gamma-Linolenic Acid results in decreased expression of PDLIM1 mRNA CTD PMID:20664735 NCBI chr10:95,237,569...95,291,006
Ensembl chr10:95,237,572...95,291,012
JBrowse link
G PLIN2 perilipin 2 increases expression EXP gamma-Linolenic Acid results in increased expression of PLIN2 mRNA CTD PMID:20664735 NCBI chr 9:19,108,391...19,127,518
Ensembl chr 9:19,108,375...19,149,290
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions EXP gamma-Linolenic Acid binds to and results in increased activity of PPARA protein CTD PMID:10403814 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions EXP gamma-Linolenic Acid binds to and results in increased activity of PPARG protein CTD PMID:15318936 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PTGR1 prostaglandin reductase 1 increases expression EXP gamma-Linolenic Acid results in increased expression of PTGR1 mRNA CTD PMID:20664735 NCBI chr 9:111,549,722...111,599,855
Ensembl chr 9:111,549,722...111,599,893
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression EXP gamma-Linolenic Acid results in increased expression of PTGS2 mRNA CTD PMID:17092368 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G S100P S100 calcium binding protein P increases expression EXP gamma-Linolenic Acid results in increased expression of S100P mRNA CTD PMID:20664735 NCBI chr 4:6,693,878...6,697,170
Ensembl chr 4:6,693,878...6,697,170
JBrowse link
G SKP2 S-phase kinase associated protein 2 decreases expression EXP gamma-Linolenic Acid results in decreased expression of SKP2 mRNA CTD PMID:20664735 NCBI chr 5:36,152,067...36,184,319
Ensembl chr 5:36,151,989...36,184,319
JBrowse link
G SLC3A2 solute carrier family 3 member 2 increases expression EXP gamma-Linolenic Acid results in increased expression of SLC3A2 mRNA CTD PMID:20664735 NCBI chr11:62,856,109...62,888,860
Ensembl chr11:62,856,102...62,888,875
JBrowse link
G ST13 ST13 Hsp70 interacting protein increases expression EXP gamma-Linolenic Acid results in increased expression of ST13 mRNA CTD PMID:20664735 NCBI chr22:40,824,535...40,856,639
Ensembl chr22:40,824,535...40,856,639
JBrowse link
G TFF3 trefoil factor 3 decreases expression EXP gamma-Linolenic Acid results in decreased expression of TFF3 mRNA CTD PMID:20664735 NCBI chr21:42,311,667...42,315,409
Ensembl chr21:42,311,667...42,315,651
JBrowse link
G TJP1 tight junction protein 1 multiple interactions EXP [gamma-Linolenic Acid co-treated with Iodine co-treated with Selenium] results in increased expression of and results in increased localization of TJP1 protein CTD PMID:16514648 NCBI chr15:29,699,367...29,969,049
Ensembl chr15:29,699,367...29,968,865
JBrowse link
G TNF tumor necrosis factor decreases expression EXP gamma-Linolenic Acid results in decreased expression of TNF protein CTD PMID:9415022 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 multiple interactions ISO gamma-Linolenic Acid inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein] CTD PMID:17038422 NCBI chr17:3,565,446...3,609,411
Ensembl chr17:3,565,444...3,609,411
JBrowse link
G TXN thioredoxin increases expression EXP gamma-Linolenic Acid results in increased expression of TXN mRNA CTD PMID:20664735 NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507
JBrowse link
G TXNRD1 thioredoxin reductase 1 increases expression EXP gamma-Linolenic Acid results in increased expression of TXNRD1 mRNA CTD PMID:20664735 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
JBrowse link
linoleamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPARG peroxisome proliferator activated receptor gamma increases activity EXP linoleamide analog results in increased activity of PPARG protein CTD PMID:29288688 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
linoleic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 multiple interactions
decreases expression
increases expression
increases phosphorylation
increases degradation
EXP
ISO
1-Butanol inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased export of Cholesterol]]; Linoleic Acid inhibits the reaction [ABCA1 protein results in increased export of Cholesterol]; Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]; Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]]; PLD2 protein inhibits the reaction [Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]]; triacsin C inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased transport of Cholesterol]]; triacsin C inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased transport of Phospholipids]]; triacsin C inhibits the reaction [Linoleic Acid results in increased degradation of ABCA1 protein]
Linoleic Acid analog results in decreased expression of ABCA1 mRNA
Linoleic Acid results in increased expression of ABCA1 mRNA
Linoleic Acid inhibits the reaction [27-hydroxycholesterol results in increased expression of ABCA1 mRNA]
Linoleic Acid results in increased phosphorylation of ABCA1 protein
CTD PMID:16118212 PMID:18356535 PMID:27939595 NCBI chr 9:104,781,006...104,928,232
Ensembl chr 9:104,781,006...104,928,155
JBrowse link
G ABCG1 ATP binding cassette subfamily G member 1 decreases expression EXP Linoleic Acid results in decreased expression of ABCG1 mRNA; Linoleic Acid results in decreased expression of ABCG1 protein CTD PMID:16730733 NCBI chr21:42,199,689...42,304,387
Ensembl chr21:42,199,689...42,297,244
JBrowse link
G ACACA acetyl-CoA carboxylase alpha decreases expression ISO Linoleic Acid results in decreased expression of ACACA mRNA CTD PMID:14563831 NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836
JBrowse link
G ACADM acyl-CoA dehydrogenase medium chain increases expression ISO Linoleic Acid results in increased expression of ACADM mRNA CTD PMID:23056435 NCBI chr 1:75,724,709...75,763,679
Ensembl chr 1:75,724,347...75,787,575
JBrowse link
G ACLY ATP citrate lyase decreases expression ISO Linoleic Acid results in decreased expression of ACLY mRNA CTD PMID:14563831 NCBI chr17:41,866,916...41,930,542
Ensembl chr17:41,866,917...41,930,542
JBrowse link
G ACMSD aminocarboxymuconate semialdehyde decarboxylase decreases expression ISO Linoleic Acid results in decreased expression of ACMSD mRNA CTD PMID:18320257 NCBI chr 2:134,838,319...134,902,906
Ensembl chr 2:134,838,616...134,902,034
JBrowse link
G ACOX1 acyl-CoA oxidase 1 increases expression ISO Linoleic Acid results in increased expression of ACOX1 mRNA CTD PMID:18320257 NCBI chr17:75,941,507...75,979,199
Ensembl chr17:75,941,507...75,979,177
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing decreases expression ISO Linoleic Acid results in decreased expression of ADIPOQ mRNA CTD PMID:17374693 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463
JBrowse link
G ADIPOR1 adiponectin receptor 1 increases expression ISO Linoleic Acid analog results in increased expression of ADIPOR1 mRNA CTD PMID:27939595 NCBI chr 1:202,940,825...202,958,572
Ensembl chr 1:202,940,826...202,958,572
JBrowse link
G AGER advanced glycosylation end-product specific receptor multiple interactions ISO AGER protein results in increased susceptibility to [Azoxymethane co-treated with Glucose co-treated with Linoleic Acid]; Glucose promotes the reaction [Linoleic Acid promotes the reaction [Azoxymethane results in increased expression of AGER protein]]; Linoleic Acid promotes the reaction [Azoxymethane results in increased expression of AGER protein]; Linoleic Acid promotes the reaction [Glucose promotes the reaction [Azoxymethane results in increased expression of AGER protein]]; Losartan inhibits the reaction [Glucose promotes the reaction [Linoleic Acid promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]; Losartan inhibits the reaction [Linoleic Acid promotes the reaction [Glucose promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]; Metformin inhibits the reaction [Glucose promotes the reaction [Linoleic Acid promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]; Metformin inhibits the reaction [Linoleic Acid promotes the reaction [Glucose promotes the reaction [Azoxymethane results in increased expression of AGER protein]]] CTD PMID:22467055 NCBI chr 6:32,180,969...32,184,380
Ensembl chr 6:32,180,968...32,184,322
JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions EXP Linoleic Acid inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]]; Linoleic Acid inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PTGS2 promoter]] CTD PMID:18001219 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G ALOX15 arachidonate 15-lipoxygenase increases oxidation EXP ALOX15 protein results in increased oxidation of Linoleic Acid CTD PMID:25786526 NCBI chr17:4,630,919...4,641,678
Ensembl chr17:4,630,919...4,642,294
Ensembl chr17:4,630,919...4,642,294
JBrowse link
G APOA1 apolipoprotein A1 multiple interactions EXP Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]; Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]]; PLD2 protein inhibits the reaction [Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]] CTD PMID:16118212 NCBI chr11:116,835,751...116,837,950
Ensembl chr11:116,835,751...116,837,622
Ensembl chr11:116,835,751...116,837,622
JBrowse link
G ASCL2 achaete-scute family bHLH transcription factor 2 decreases expression EXP Linoleic Acid results in decreased expression of ASCL2 mRNA CTD PMID:15708366 NCBI chr11:2,268,498...2,270,588
Ensembl chr11:2,268,495...2,270,952
JBrowse link
G BCHE butyrylcholinesterase increases expression EXP Linoleic Acid results in increased expression of BCHE mRNA CTD PMID:27106529 NCBI chr 3:165,772,904...165,837,423
Ensembl chr 3:165,772,904...165,837,462
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions ISO [Linoleic Acid co-treated with Glucose] affects the reaction [Azoxymethane affects the expression of BCL2 protein]; Linoleic Acid affects the reaction [Azoxymethane affects the expression of BCL2 protein] CTD PMID:22467055 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CAT catalase increases expression EXP Linoleic Acid results in increased expression of CAT protein CTD PMID:10946007 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCL2 C-C motif chemokine ligand 2 increases expression EXP Linoleic Acid results in increased expression of CCL2 protein CTD PMID:16305726 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CD36 CD36 molecule multiple interactions ISO [Oleic Acid co-treated with Linoleic Acid] results in increased expression of CD36 mRNA CTD PMID:28552552 NCBI chr 7:80,602,207...80,679,277
Ensembl chr 7:80,369,575...80,679,277
JBrowse link
G CGB3 chorionic gonadotropin subunit beta 3 decreases secretion EXP Linoleic Acid results in decreased secretion of CGB3 protein CTD PMID:15708366 NCBI chr19:49,022,869...49,024,333
Ensembl chr19:49,022,869...49,024,333
JBrowse link
G CNR1 cannabinoid receptor 1 affects response to substance
multiple interactions
ISO CNR1 protein affects the susceptibility to Linoleic Acid
CNR1 protein affects the reaction [Linoleic Acid results in increased secretion of GCG protein]
CTD PMID:30241419 NCBI chr 6:88,139,864...88,167,349
Ensembl chr 6:88,139,864...88,166,359
JBrowse link
G COL1A1 collagen type I alpha 1 chain increases expression ISO Linoleic Acid results in increased expression of COL1A1 mRNA CTD PMID:26240151 NCBI chr17:50,184,096...50,201,649
Ensembl chr17:50,183,289...50,201,632
Ensembl chr17:50,183,289...50,201,632
JBrowse link
G COL3A1 collagen type III alpha 1 chain decreases expression ISO Linoleic Acid results in decreased expression of COL3A1 mRNA CTD PMID:26240151 NCBI chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746
JBrowse link
G CPT1A carnitine palmitoyltransferase 1A increases expression ISO Linoleic Acid results in increased expression of CPT1A mRNA CTD PMID:11171094 NCBI chr11:68,754,620...68,844,410
Ensembl chr11:68,754,620...68,844,410
JBrowse link
G CREBBP CREB binding protein multiple interactions EXP Linoleic Acid affects the reaction [PPARA protein binds to CREBBP protein] CTD PMID:19263263 NCBI chr16:3,725,054...3,880,727
Ensembl chr16:3,725,054...3,880,713
Ensembl chr16:3,725,054...3,880,713
JBrowse link
G CYCS cytochrome c, somatic multiple interactions EXP [Oleic Acid co-treated with Linoleic Acid] results in increased expression of CYCS protein CTD PMID:27016407 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions EXP Linoleic Acid inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]] CTD PMID:18001219 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 decreases activity EXP Linoleic Acid results in decreased activity of CYP1A2 protein CTD PMID:16978661 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 multiple interactions
increases expression
EXP NFE2L2 protein promotes the reaction [Linoleic Acid results in increased expression of CYP2A6 mRNA]; NFE2L2 protein promotes the reaction [Linoleic Acid results in increased expression of CYP2A6 protein]
Linoleic Acid results in increased expression of CYP2A6 mRNA; Linoleic Acid results in increased expression of CYP2A6 protein
CTD PMID:28555106 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447
JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 multiple interactions
decreases activity
EXP CYP2C19 protein results in increased metabolism of [Linoleic Acid co-treated with NADP]
Linoleic Acid results in decreased activity of CYP2C19 protein
CTD PMID:16978661 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 multiple interactions
decreases activity
EXP CYP2C9 protein results in increased metabolism of [Linoleic Acid co-treated with NADP]
Linoleic Acid results in decreased activity of CYP2C9 protein
CTD PMID:16978661 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 decreases activity EXP Linoleic Acid results in decreased activity of CYP2E1 protein CTD PMID:16978661 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 decreases activity EXP Linoleic Acid results in decreased activity of CYP3A4 protein CTD PMID:16978661 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases expression ISO Linoleic Acid analog results in increased expression of DDIT3 protein CTD PMID:27939595 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
JBrowse link
G DIO1 iodothyronine deiodinase 1 decreases activity EXP Linoleic Acid results in decreased activity of DIO1 protein CTD PMID:30561685 NCBI chr 1:53,894,187...53,911,086
Ensembl chr 1:53,891,239...53,911,086
JBrowse link
G DIO2 iodothyronine deiodinase 2 decreases activity EXP Linoleic Acid results in decreased activity of DIO2 protein CTD PMID:30561685 NCBI chr14:80,197,526...80,231,057
Ensembl chr14:80,197,527...80,387,757
Ensembl chr14:80,197,527...80,387,757
JBrowse link
G DIO3 iodothyronine deiodinase 3 decreases activity EXP Linoleic Acid results in decreased activity of DIO3 protein CTD PMID:30561685 NCBI chr14:101,561,351...101,563,452
Ensembl chr14:101,561,351...101,563,452
JBrowse link
G EDN1 endothelin 1 decreases expression EXP Linoleic Acid results in decreased expression of EDN1 mRNA; Linoleic Acid results in decreased expression of EDN1 protein CTD PMID:16895544 NCBI chr 6:12,256,463...12,297,194
Ensembl chr 6:12,290,361...12,297,194
JBrowse link
G FABP1 fatty acid binding protein 1 decreases expression EXP Linoleic Acid results in decreased expression of FABP1 mRNA CTD PMID:15708366 NCBI chr 2:88,122,982...88,128,062
Ensembl chr 2:88,122,982...88,128,062
JBrowse link
G FABP3 fatty acid binding protein 3 decreases expression EXP Linoleic Acid results in decreased expression of FABP3 mRNA CTD PMID:15708366 NCBI chr 1:31,359,595...31,373,618
Ensembl chr 1:31,365,253...31,376,850
JBrowse link
G FABP4 fatty acid binding protein 4 affects localization ISO Linoleic Acid analog affects the localization of FABP4 protein CTD PMID:27939595 NCBI chr 8:81,478,419...81,483,233
Ensembl chr 8:81,478,419...81,483,236
JBrowse link
G FADS2 fatty acid desaturase 2 multiple interactions
increases expression
EXP
ISO
[Linoleic Acid co-treated with Testosterone] results in increased expression of FADS2 mRNA
FADS2 protein inhibits the reaction [Linoleic Acid results in increased activity of LOX protein]
Linoleic Acid results in increased expression of FADS2 mRNA; Linoleic Acid results in increased expression of FADS2 protein
CTD PMID:21457203 PMID:26240151 NCBI chr11:61,816,203...61,867,354
Ensembl chr11:61,792,980...61,867,354
JBrowse link
G FASN fatty acid synthase decreases expression ISO Linoleic Acid results in decreased expression of FASN mRNA CTD PMID:14563831 NCBI chr17:82,078,338...82,098,303
Ensembl chr17:82,078,338...82,098,294
JBrowse link
G FFAR3 free fatty acid receptor 3 increases expression ISO Linoleic Acid analog results in increased expression of FFAR3 mRNA CTD PMID:27939595 NCBI chr19:35,358,106...35,360,491
Ensembl chr19:35,358,460...35,360,489
JBrowse link
G FOXO1 forkhead box O1 decreases expression ISO Linoleic Acid results in decreased expression of FOXO1 protein CTD PMID:17374693 NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641
JBrowse link
G GCG glucagon multiple interactions ISO CNR1 protein affects the reaction [Linoleic Acid results in increased secretion of GCG protein] CTD PMID:30241419 NCBI chr 2:162,142,882...162,152,247
Ensembl chr 2:162,142,882...162,152,404
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit increases expression EXP Linoleic Acid metabolite results in increased expression of GCLM mRNA CTD PMID:26879219 NCBI chr 1:93,885,199...93,910,370
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
G GJB1 gap junction protein beta 1 increases abundance ISO GJB1 protein results in increased abundance of Linoleic Acid CTD PMID:27859493 NCBI chr  X:71,215,239...71,225,516
Ensembl chr  X:71,212,811...71,225,516
Ensembl chr  X:71,212,811...71,225,516
JBrowse link
G GSTA1 glutathione S-transferase alpha 1 multiple interactions
increases expression
EXP NFE2L2 protein promotes the reaction [Linoleic Acid results in increased expression of GSTA1 mRNA] CTD PMID:28555106 NCBI chr 6:52,791,371...52,803,827
Ensembl chr 6:52,791,371...52,803,860
JBrowse link
G GSTA4 glutathione S-transferase alpha 4 increases expression ISO Linoleic Acid metabolite results in increased expression of GSTA4 mRNA CTD PMID:26879219 NCBI chr 6:52,977,952...52,995,332
Ensembl chr 6:52,977,948...52,995,304
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
increases expression
EXP
ISO
NFE2L2 mRNA promotes the reaction [Linoleic Acid metabolite results in increased expression of HMOX1 mRNA]
Linoleic Acid metabolite results in increased expression of HMOX1 mRNA; Linoleic Acid metabolite results in increased expression of HMOX1 protein
CTD PMID:26879219 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression ISO Linoleic Acid analog results in increased expression of HSPA5 protein CTD PMID:27939595 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,343
JBrowse link
G IFNG interferon gamma increases expression EXP Linoleic Acid results in increased expression of IFNG protein CTD PMID:16305726 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL10 interleukin 10 increases expression EXP Linoleic Acid results in increased expression of IL10 protein CTD PMID:16305726 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL1B interleukin 1 beta increases expression EXP Linoleic Acid results in increased expression of IL1B protein CTD PMID:16305726 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL2 interleukin 2 decreases expression EXP Linoleic Acid results in decreased expression of IL2 protein CTD PMID:16305726 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G IL4 interleukin 4 decreases expression EXP Linoleic Acid results in decreased expression of IL4 protein CTD PMID:16305726 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G IL5 interleukin 5 decreases expression EXP Linoleic Acid results in decreased expression of IL5 protein CTD PMID:16305726 NCBI chr 5:132,539,194...132,556,864
Ensembl chr 5:132,541,445...132,556,838
JBrowse link
G IL6 interleukin 6 affects expression
increases expression
increases secretion
EXP
ISO
Linoleic Acid affects the expression of IL6 protein
Linoleic Acid results in increased expression of IL6 mRNA
Linoleic Acid results in increased secretion of IL6 protein
CTD PMID:16305726 PMID:17374693 PMID:21457203 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G INSR insulin receptor increases expression ISO Linoleic Acid analog results in increased expression of INSR mRNA CTD PMID:27939595 NCBI chr19:7,112,257...7,294,414
Ensembl chr19:7,112,255...7,294,414
JBrowse link
G LCAT lecithin-cholesterol acyltransferase increases expression ISO Linoleic Acid analog results in increased expression of LCAT mRNA CTD PMID:27939595 NCBI chr16:67,939,750...67,944,120
Ensembl chr16:67,939,750...67,944,131
JBrowse link
G LIPC lipase C, hepatic type multiple interactions ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in decreased abundance of Linoleic Acid CTD PMID:24777581 NCBI chr15:58,410,457...58,569,844
Ensembl chr15:58,410,569...58,569,844
JBrowse link
G LIPG lipase G, endothelial type multiple interactions ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in decreased abundance of Linoleic Acid CTD PMID:24777581 NCBI chr18:49,560,699...49,599,185
Ensembl chr18:49,560,699...49,599,185
JBrowse link
G LOX lysyl oxidase multiple interactions
increases activity
ISO FADS2 protein inhibits the reaction [Linoleic Acid results in increased activity of LOX protein]; TGFB1 protein promotes the reaction [Linoleic Acid results in increased activity of LOX protein] CTD PMID:26240151 NCBI chr 5:122,063,195...122,078,259
Ensembl chr 5:122,063,195...122,078,360
JBrowse link
G LPIN1 lipin 1 decreases expression ISO Linoleic Acid analog results in decreased expression of LPIN1 mRNA CTD PMID:27939595 NCBI chr 2:11,677,544...11,827,409
Ensembl chr 2:11,677,595...11,827,409
JBrowse link
G LRAT lecithin retinol acyltransferase increases expression ISO Linoleic Acid results in increased expression of LRAT mRNA CTD PMID:12576510 NCBI chr 4:154,740,838...154,753,120
Ensembl chr 4:154,626,945...154,753,120
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP Linoleic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:23288142 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions
decreases expression
EXP
ISO
Linoleic Acid results in decreased expression of and results in decreased activity of MMP9 protein
[Linoleic Acid co-treated with Glucose] affects the reaction [Azoxymethane affects the expression of MMP9 protein]; Linoleic Acid affects the reaction [Azoxymethane affects the expression of MMP9 protein]
Linoleic Acid results in decreased expression of MMP9 mRNA
CTD PMID:22467055 PMID:23288142 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G NCF1 neutrophil cytosolic factor 1 multiple interactions EXP Linoleic Acid affects the reaction [Zymosan analog affects the localization of NCF1 protein] CTD PMID:12101222 NCBI chr 7:74,773,962...74,789,376
Ensembl chr 7:74,773,962...74,789,376
JBrowse link
G NCF2 neutrophil cytosolic factor 2 multiple interactions EXP Linoleic Acid affects the reaction [Zymosan analog affects the localization of NCF2 protein] CTD PMID:12101222 NCBI chr 1:183,555,562...183,590,914
Ensembl chr 1:183,555,563...183,590,876
Ensembl chr 1:183,555,563...183,590,876
JBrowse link
G NCOA1 nuclear receptor coactivator 1 multiple interactions EXP Linoleic Acid promotes the reaction [PPARA protein binds to NCOA1 protein] CTD PMID:19263263 NCBI chr 2:24,491,254...24,770,702
Ensembl chr 2:24,491,914...24,770,702
JBrowse link
G NCOA2 nuclear receptor coactivator 2 multiple interactions EXP Linoleic Acid promotes the reaction [PPARA protein binds to NCOA2 protein] CTD PMID:19263263 NCBI chr 8:70,109,770...70,405,390
Ensembl chr 8:70,109,782...70,403,808
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 increases expression
multiple interactions
EXP
ISO
Linoleic Acid metabolite results in increased expression of NFE2L2 protein; Linoleic Acid results in increased expression of NFE2L2 mRNA; Linoleic Acid results in increased expression of NFE2L2 protein
NFE2L2 mRNA promotes the reaction [Linoleic Acid metabolite results in increased expression of HMOX1 mRNA]; NFE2L2 protein promotes the reaction [Linoleic Acid results in increased expression of CYP2A6 mRNA]; NFE2L2 protein promotes the reaction [Linoleic Acid results in increased expression of CYP2A6 protein]; NFE2L2 protein promotes the reaction [Linoleic Acid results in increased expression of GSTA1 mRNA]
CTD PMID:26879219 PMID:28555106 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO [Linoleic Acid co-treated with Glucose] affects the reaction [Azoxymethane affects the expression of NOS2 protein]; Linoleic Acid affects the reaction [Azoxymethane affects the expression of NOS2 protein] CTD PMID:22467055 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NOS3 nitric oxide synthase 3 decreases expression EXP Linoleic Acid results in decreased expression of NOS3 mRNA CTD PMID:16895544 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression EXP
ISO
Linoleic Acid metabolite results in increased expression of NQO1 mRNA CTD PMID:26879219 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G NR5A2 nuclear receptor subfamily 5 group A member 2 multiple interactions ISO [NR5A2 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Linoleic Acid analog CTD PMID:29515023 NCBI chr 1:200,027,710...200,177,415
Ensembl chr 1:200,027,614...200,177,420
JBrowse link
G PCK1 phosphoenolpyruvate carboxykinase 1 multiple interactions ISO [Glucose deficiency co-treated with Linoleic Acid] results in increased expression of PCK1 mRNA CTD PMID:8536680 NCBI chr20:57,561,110...57,568,121
Ensembl chr20:57,561,080...57,568,121
JBrowse link
G PDK4 pyruvate dehydrogenase kinase 4 increases expression ISO Linoleic Acid results in increased expression of PDK4 mRNA CTD PMID:23056435 NCBI chr 7:95,583,499...95,596,516
Ensembl chr 7:95,583,499...95,596,516
JBrowse link
G PLD2 phospholipase D2 multiple interactions EXP PLD2 protein inhibits the reaction [Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]] CTD PMID:16118212 NCBI chr17:4,807,152...4,823,432
Ensembl chr17:4,807,152...4,823,434
JBrowse link
G PLIN1 perilipin 1 increases expression ISO Linoleic Acid analog results in increased expression of PLIN1 mRNA CTD PMID:27939595 NCBI chr15:89,664,365...89,679,367
Ensembl chr15:89,664,367...89,679,427
JBrowse link
G PON1 paraoxonase 1 multiple interactions
decreases activity
EXP Linoleic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; Linoleic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid]
Linoleic Acid results in decreased activity of PON1 protein
CTD PMID:12871208 PMID:15375178 NCBI chr 7:95,297,676...95,324,532
Ensembl chr 7:95,297,676...95,324,532
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions
increases expression
affects abundance
increases activity
affects binding
EXP
ISO
[Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased oxidation of Linoleic Acid; Linoleic Acid affects the reaction [PPARA protein binds to CREBBP protein]; Linoleic Acid binds to and results in increased activity of PPARA protein; Linoleic Acid promotes the reaction [PPARA protein binds to NCOA1 protein]; Linoleic Acid promotes the reaction [PPARA protein binds to NCOA2 protein]
Linoleic Acid results in increased expression of PPARA mRNA
PPARA protein affects the abundance of Linoleic Acid
Diethylhexyl Phthalate inhibits the reaction [PPARA protein affects the abundance of Linoleic Acid]; Linoleic Acid binds to and results in increased activity of PPARA protein
Linoleic Acid results in increased expression of PPARA mRNA; Linoleic Acid results in increased expression of PPARA protein
Linoleic Acid results in increased activity of PPARA protein
Linoleic Acid binds to PPARA protein
CTD PMID:10403814 PMID:11172467 PMID:15491415 PMID:16731579 PMID:18154422 PMID:19263263 PMID:20404010 PMID:23056435 PMID:23619606 PMID:23843199 PMID:25786526 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
G PPARD peroxisome proliferator activated receptor delta multiple interactions
decreases expression
increases expression
increases activity
affects binding
EXP
ISO
Linoleic Acid binds to and results in increased activity of PPARB protein
Linoleic Acid results in decreased expression of PPARD mRNA
Linoleic Acid results in increased expression of PPARD mRNA
Linoleic Acid results in increased activity of PPARD protein
Linoleic Acid binds to PPARB protein
CTD PMID:11172467 PMID:15708366 PMID:16731579 PMID:23843199 PMID:25786526 NCBI chr 6:35,342,558...35,428,180
Ensembl chr 6:35,342,558...35,428,191
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma affects binding
multiple interactions
increases expression
increases activity
decreases expression
EXP
ISO
Linoleic Acid binds to PPARG protein
Linoleic Acid binds to and results in increased activity of PPARG protein
Linoleic Acid results in increased expression of PPARG mRNA
resveratrol inhibits the reaction [Linoleic Acid results in increased expression of PPARG protein]
Linoleic Acid results in increased activity of PPARG protein
Linoleic Acid results in decreased expression of PPARG mRNA; Linoleic Acid results in decreased expression of PPARG protein
CTD PMID:11172467 PMID:12021203 PMID:15708366 PMID:16731579 PMID:18154422 PMID:23843199 PMID:25672876 PMID:25786526 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha increases expression ISO
EXP
Linoleic Acid results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
JBrowse link
G PPARGC1B PPARG coactivator 1 beta increases expression ISO Linoleic Acid results in increased expression of PPARGC1B mRNA CTD PMID:23056435 NCBI chr 5:149,730,302...149,857,861
Ensembl chr 5:149,730,298...149,855,022
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO
EXP
Linoleic Acid results in increased expression of PTGS2 mRNA
Linoleic Acid inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 mRNA]; Linoleic Acid inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PTGS2 promoter]]; Linoleic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]
CTD PMID:14563831 PMID:18001219 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G RXRA retinoid X receptor alpha affects binding
multiple interactions
EXP Linoleic Acid binds to RXRA protein
Linoleic Acid binds to and results in increased activity of RXRA protein
CTD PMID:16258897 PMID:16731579 NCBI chr 9:134,326,455...134,440,585
Ensembl chr 9:134,317,098...134,440,585
JBrowse link
G SCD stearoyl-CoA desaturase multiple interactions
increases expression
EXP [Linoleic Acid co-treated with Testosterone] results in increased expression of SCD mRNA
Linoleic Acid results in increased expression of SCD mRNA; Linoleic Acid results in increased expression of SCD protein
CTD PMID:21457203 NCBI chr10:100,347,233...100,364,826
Ensembl chr10:100,347,233...100,364,826
JBrowse link
G SERPINE1 serpin family E member 1 increases expression ISO Linoleic Acid results in increased expression of SERPINE1 mRNA CTD PMID:17374693 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
JBrowse link
G SLC22A6 solute carrier family 22 member 6 decreases activity EXP Linoleic Acid results in decreased activity of SLC22A6 protein CTD PMID:29045746 NCBI chr11:62,976,597...62,984,967
Ensembl chr11:62,936,385...62,984,967
Ensembl chr11:62,936,385...62,984,967
JBrowse link
G SLC22A8 solute carrier family 22 member 8 decreases activity EXP Linoleic Acid results in decreased activity of SLC22A8 protein CTD PMID:29045746 NCBI chr11:62,992,824...63,015,841
Ensembl chr11:62,989,154...63,015,841
JBrowse link
G SMAD3 SMAD family member 3 decreases abundance ISO SMAD3 protein results in decreased abundance of Linoleic Acid CTD PMID:23034213 NCBI chr15:67,065,602...67,195,195
Ensembl chr15:67,063,763...67,195,169
JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 decreases expression ISO Linoleic Acid results in decreased expression of SREBF1 mRNA CTD PMID:14563831 NCBI chr17:17,811,334...17,837,017
Ensembl chr17:17,810,399...17,837,011
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO TGFB1 protein promotes the reaction [Linoleic Acid results in increased activity of LOX protein] CTD PMID:26240151 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TNF tumor necrosis factor decreases response to substance EXP Linoleic Acid results in decreased susceptibility to TNF protein CTD PMID:22683933 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 multiple interactions ISO TRPV1 results in increased susceptibility to [Linoleic Acid co-treated with Freund's Adjuvant] CTD PMID:23006841 NCBI chr17:3,565,446...3,609,411
Ensembl chr17:3,565,444...3,609,411
JBrowse link
G UCP2 uncoupling protein 2 increases expression ISO Linoleic Acid results in increased expression of UCP2 mRNA CTD PMID:11341955 NCBI chr11:73,974,671...73,983,202
Ensembl chr11:73,974,672...73,983,246
JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions ISO [Linoleic Acid co-treated with Glucose] affects the reaction [Azoxymethane affects the expression of VEGFA protein] CTD PMID:22467055 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
G WNT10B Wnt family member 10B decreases expression ISO Linoleic Acid results in decreased expression of WNT10B mRNA CTD PMID:12021203 NCBI chr12:48,965,340...48,979,587
Ensembl chr12:48,965,340...48,971,735
JBrowse link
linoleic acid hydroperoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen multiple interactions
increases lipidation
EXP Ascorbic Acid promotes the reaction [linoleic acid hydroperoxide results in increased lipidation of AGT protein modified form] CTD PMID:26111765 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,702,523...230,714,122
JBrowse link
G CYGB cytoglobin increases metabolic processing ISO CYGB protein results in increased metabolism of linoleic acid hydroperoxide CTD PMID:11320098 NCBI chr17:76,527,356...76,557,692
Ensembl chr17:76,527,356...76,551,175
JBrowse link
G GPX1 glutathione peroxidase 1 increases reduction EXP GPX1 protein results in increased reduction of linoleic acid hydroperoxide CTD PMID:8428933 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,176...49,358,358
JBrowse link
G GPX2 glutathione peroxidase 2 increases reduction EXP GPX2 protein results in increased reduction of linoleic acid hydroperoxide CTD PMID:8428933 NCBI chr14:64,939,158...64,942,745
Ensembl chr14:64,939,152...64,942,905
JBrowse link
lipoxin A4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions ISO AHR affects the reaction [lipoxin A4 results in increased expression of SOCS2 mRNA] CTD PMID:16415877 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G ALOX5 arachidonate 5-lipoxygenase multiple interactions
affects abundance
ISO zileuton inhibits the reaction [ALOX5 protein affects the abundance of lipoxin A4] CTD PMID:15326064 NCBI chr10:45,374,209...45,446,121
Ensembl chr10:45,374,176...45,446,119
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein] CTD PMID:23063943 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions EXP lipoxin A4 inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein] CTD PMID:23063943 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 multiple interactions ISO lipoxin A4 analog inhibits the reaction [TNF protein results in increased secretion of CXCL2 protein] CTD PMID:10377187 NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions
decreases expression
EXP lipoxin A4 analog inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA]; lipoxin A4 analog inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL8 protein]; lipoxin A4 inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased secretion of CXCL8 protein]; lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA]; lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL8 protein]
lipoxin A4 analog results in decreased expression of CXCL8 protein
CTD PMID:12235371 PMID:21659618 PMID:23063943 PMID:27663891 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G FPR2 formyl peptide receptor 2 multiple interactions
increases activity
EXP
ISO
[Aspirin results in increased abundance of lipoxin A4] which results in increased expression of FPR2; lipoxin A4 analog binds to and results in decreased activity of FPR2 protein
lipoxin A4 inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of FPR2 mRNA]
lipoxin A4 results in increased activity of FPR2
CTD PMID:12594298 PMID:19597002 PMID:21765620 NCBI chr19:51,752,026...51,770,531
Ensembl chr19:51,752,026...51,770,531
JBrowse link
G HMOX1 heme oxygenase 1 increases expression
multiple interactions
ISO lipoxin A4 results in increased expression of HMOX1 mRNA; lipoxin A4 results in increased expression of HMOX1 protein
lipoxin A4 promotes the reaction [NFE2L2 protein binds to HMOX1 enhancer]
CTD PMID:23826208 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G ICAM1 intercellular adhesion molecule 1 affects response to substance EXP ICAM1 protein affects the susceptibility to lipoxin A4 CTD PMID:7602232 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
JBrowse link
G IL1B interleukin 1 beta decreases expression
multiple interactions
decreases secretion
EXP
ISO
lipoxin A4 analog results in decreased expression of IL1B protein
butyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanine inhibits the reaction [lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; butyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanine inhibits the reaction [lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; lipoxin A4 analog inhibits the reaction [TNF protein results in increased secretion of IL1B protein]; lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
lipoxin A4 analog results in decreased secretion of IL1B protein
lipoxin A4 analog inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]; lipoxin A4 analog inhibits the reaction [TNF protein results in increased secretion of IL1B protein]; lipoxin A4 inhibits the reaction [TNF protein results in increased secretion of IL1B protein]
CTD PMID:10377187 PMID:21659618 PMID:21831303 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL4 interleukin 4 increases secretion ISO lipoxin A4 analog results in increased secretion of IL4 protein CTD PMID:10377187 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G IL6 interleukin 6 multiple interactions EXP lipoxin A4 inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased secretion of IL6 protein] CTD PMID:27663891 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:21831303 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:21831303 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 affects localization
multiple interactions
ISO lipoxin A4 affects the localization of NFE2L2 protein
lipoxin A4 promotes the reaction [NFE2L2 protein binds to HMOX1 enhancer]
CTD PMID:23826208 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein] CTD PMID:21831303 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO butyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanine inhibits the reaction [lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; butyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanine inhibits the reaction [lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:21831303 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G PDGFB platelet derived growth factor subunit B multiple interactions EXP lipoxin A4 affects the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]; PDGFB protein promotes the reaction [lipoxin A4 results in decreased phosphorylation of PDGFRB protein] CTD PMID:12223454 PMID:20709806 NCBI chr22:39,223,359...39,244,982
Ensembl chr22:39,223,359...39,244,982
JBrowse link
G PDGFRB platelet derived growth factor receptor beta multiple interactions
decreases phosphorylation
EXP lipoxin A4 affects the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]; lipoxin A4 inhibits the reaction [Leukotriene D4 results in increased activity of PDGFRB protein]; PDGFB protein promotes the reaction [lipoxin A4 results in decreased phosphorylation of PDGFRB protein] CTD PMID:12223454 PMID:20709806 NCBI chr 5:150,113,839...150,155,845
Ensembl chr 5:150,113,839...150,155,872
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions ISO lipoxin A4 binds to and results in increased activity of PPARG protein CTD PMID:19321784 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PTAFR platelet activating factor receptor multiple interactions EXP [WEB 2086 binds to and results in decreased activity of PTAFR protein] which results in decreased susceptibility to lipoxin A4 CTD PMID:7602232 NCBI chr 1:28,147,166...28,193,856
Ensembl chr 1:28,147,166...28,193,936
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions
affects abundance
ISO [lipoxin A4 co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of PTGS2 protein; Celecoxib inhibits the reaction [PTGS2 protein affects the abundance of lipoxin A4]; lipoxin A4 inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein] CTD PMID:15326064 PMID:21765620 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO
lipoxin A4 inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]
lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]
CTD PMID:21831303 PMID:23063943 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G SELP selectin P affects response to substance EXP SELP protein affects the susceptibility to lipoxin A4 CTD PMID:7602232 NCBI chr 1:169,588,849...169,630,125
Ensembl chr 1:169,588,849...169,630,193
JBrowse link
G SOCS2 suppressor of cytokine signaling 2 multiple interactions
increases expression
ISO AHR affects the reaction [lipoxin A4 results in increased expression of SOCS2 mRNA]; butyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanine inhibits the reaction [lipoxin A4 results in increased expression of SOCS2 mRNA]
lipoxin A4 results in increased expression of SOCS2 mRNA; lipoxin A4 results in increased expression of SOCS2 protein
CTD PMID:16415877 NCBI chr12:93,569,849...93,626,236
Ensembl chr12:93,569,814...93,583,487
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP
ISO
lipoxin A4 analog inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]; lipoxin A4 analog inhibits the reaction [TNF protein results in increased secretion of IL1B protein]; lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; lipoxin A4 inhibits the reaction [TNF protein results in increased secretion of IL1B protein]
butyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanine inhibits the reaction [lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; butyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanine inhibits the reaction [lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; lipoxin A4 analog inhibits the reaction [TNF protein results in increased secretion of CXCL2 protein]; lipoxin A4 analog inhibits the reaction [TNF protein results in increased secretion of IL1B protein]; lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD PMID:10377187 PMID:21575454 PMID:21831303 PMID:23063943 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 24370
    chemical entity 24338
      atom 24327
        nonmetal atom 24029
          carbon atom 23906
            organic molecular entity 23906
              lipid 19679
                fatty acid 18317
                  unsaturated fatty acid 946
                    polyunsaturated fatty acid 680
                      omega-6 fatty acid 387
                        (10Z,13Z,16Z)-docosatrienoic acid + 0
                        (10Z,13Z,16Z,19Z,22Z)-octacosapentaenoic acid + 0
                        (11Z,14Z,17Z,20Z)-hexacosatetraenoic acid + 0
                        (12Z,15Z,18Z,21Z,24Z)-triacontapentaenoic acid + 0
                        (13Z,16Z,19Z,22Z)-octacosatetraenoic acid + 0
                        (14Z,17Z,20Z,23Z,26Z)-dotriacontapentaenoic acid + 0
                        (15Z,18Z,21Z,24Z)-triacontatetraenoic acid + 0
                        (16Z,19Z,22Z,25Z,28Z)-tetratriacontapentaenoic acid + 0
                        (17Z,20Z,23Z,26Z)-dotriacontatetraenoic acid + 0
                        (18Z,21Z,24Z,27Z,30Z)-hexatriacontapentaenoic acid + 0
                        (19Z,22Z,25Z,28Z)-tetratriacontatetraenoic acid + 0
                        (20Z,23Z,26Z,29Z,32Z)-octatriacontapentaenoic acid + 0
                        (21Z,24Z,27Z,30Z)-hexatriacontatetraenoic acid + 0
                        (23Z,26Z,29Z,32Z)-octatriacontatetraenoic acid + 0
                        (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoic acid + 4
                        (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoic acid + 0
                        (8E,10E,12Z)-octadecatrienoic acid + 0
                        (8Z,11Z,14Z,17Z,20Z)-hexacosapentaenoic acid + 0
                        (9Z,12Z,15Z,18Z)-tetracosatetraenoic acid + 0
                        all-cis-docosa-7,10,13,16-tetraenoic acid + 2
                        arachidonic acid + 271
                        cis-4-decenoic acid + 0
                        fatty acid 18:3-omega-3omega-6 0
                        fatty acid 20:3-omega-3omega-6 0
                        fatty acid 20:4-omega-6 0
                        fatty acid 22:5-omega-6 0
                        gamma-linolenic acid + 44
                        linoelaidic acid 0
                        linoleic acid + 114
                        lysophosphatidylcholine 0:0/20:3-omega-3omega-6 0
                        lysophosphatidylcholine 18:3-omega-3omega-6 + 0
                        lysophosphatidylcholine 18:3-omega-3omega-6/0:0 0
                        lysophosphatidylcholine 20:3-omega-3omega-6 + 0
                        lysophosphatidylcholine 20:3-omega-3omega-6/0:0 0
                        lysophosphatidylcholine 22:5-omega-6 0
                        lysophosphatidylcholine 22:5-omega-6/0:0 0
                        lysophosphatidylethanolamine 20:3-omega-3omega-6 0
                        lysophosphatidylethanolamine 22:5-omega-6 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 24370
    subatomic particle 24327
      composite particle 24327
        hadron 24327
          baryon 24327
            nucleon 24327
              atomic nucleus 24327
                atom 24327
                  main group element atom 24173
                    p-block element atom 24173
                      carbon group element atom 23949
                        carbon atom 23906
                          organic molecular entity 23906
                            organic group 22190
                              organic divalent group 22164
                                organodiyl group 22164
                                  carbonyl group 22147
                                    carbonyl compound 22147
                                      carboxylic acid 21187
                                        monocarboxylic acid 20077
                                          fatty acid 18317
                                            unsaturated fatty acid 946
                                              polyunsaturated fatty acid 680
                                                essential fatty acid 394
                                                  omega-6 fatty acid 387
                                                    (10Z,13Z,16Z)-docosatrienoic acid + 0
                                                    (10Z,13Z,16Z,19Z,22Z)-octacosapentaenoic acid + 0
                                                    (11Z,14Z,17Z,20Z)-hexacosatetraenoic acid + 0
                                                    (12Z,15Z,18Z,21Z,24Z)-triacontapentaenoic acid + 0
                                                    (13Z,16Z,19Z,22Z)-octacosatetraenoic acid + 0
                                                    (14Z,17Z,20Z,23Z,26Z)-dotriacontapentaenoic acid + 0
                                                    (15Z,18Z,21Z,24Z)-triacontatetraenoic acid + 0
                                                    (16Z,19Z,22Z,25Z,28Z)-tetratriacontapentaenoic acid + 0
                                                    (17Z,20Z,23Z,26Z)-dotriacontatetraenoic acid + 0
                                                    (18Z,21Z,24Z,27Z,30Z)-hexatriacontapentaenoic acid + 0
                                                    (19Z,22Z,25Z,28Z)-tetratriacontatetraenoic acid + 0
                                                    (20Z,23Z,26Z,29Z,32Z)-octatriacontapentaenoic acid + 0
                                                    (21Z,24Z,27Z,30Z)-hexatriacontatetraenoic acid + 0
                                                    (23Z,26Z,29Z,32Z)-octatriacontatetraenoic acid + 0
                                                    (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoic acid + 4
                                                    (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoic acid + 0