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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3-hydroxy monocarboxylic acid
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Accession:CHEBI:35969 term browser browse the term
Definition:A hydroxy monocarboxylic acid that has a hydroxy group beta to the carboxy group.
Synonyms:related_synonym: 3-hydroxy acid;   3-hydroxy monocarboxylic acids;   beta-hydroxy acid;   beta-hydroxy acids;   beta-hydroxy carboxylic acid;   beta-hydroxy carboxylic acids


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(S)-atropine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO Hyoscyamine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr17:12,584,189...12,628,489
Ensembl chr17:12,584,132...12,628,488
JBrowse link
3-hydroxybutyric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aqp9 aquaporin 9 increases uptake ISO AQP9 protein results in increased uptake of 3-Hydroxybutyric Acid CTD PMID:9733774 NCBI chr 9:71,110,659...71,167,849
Ensembl chr 9:71,110,659...71,168,682
JBrowse link
G Atg5 autophagy related 5 increases abundance ISO ATG5 protein results in increased abundance of 3-Hydroxybutyric Acid CTD PMID:25943029 NCBI chr10:44,268,322...44,364,299
Ensembl chr10:44,268,358...44,364,291
JBrowse link
G Becn1 beclin 1, autophagy related increases abundance ISO BECN1 protein results in increased abundance of 3-Hydroxybutyric Acid CTD PMID:25943029 NCBI chr11:101,288,258...101,302,286
Ensembl chr11:101,285,952...101,302,286
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
3-Hydroxybutyric Acid inhibits the reaction [Rotenone results in increased activity of CASP3 protein]
3-Hydroxybutyric Acid promotes the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased expression of CASP3 protein]
CTD PMID:16917840 PMID:31332890 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp8 caspase 8 multiple interactions EXP 3-Hydroxybutyric Acid promotes the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased expression of CASP8 protein] CTD PMID:31332890 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503
JBrowse link
G Casp9 caspase 9 multiple interactions ISO
EXP
3-Hydroxybutyric Acid inhibits the reaction [Rotenone results in increased activity of CASP9 protein]
3-Hydroxybutyric Acid promotes the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased expression of CASP9 protein]
CTD PMID:16917840 PMID:31332890 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 multiple interactions EXP [[CYP3A11 protein co-treated with CYP3A16 protein co-treated with CYP3A25 protein co-treated with CYP3A41A protein co-treated with CYP3A44 protein co-treated with CYP3A57 protein co-treated with CYP3A59 protein] affects the susceptibility to Dietary Fats] which affects the abundance of 3-Hydroxybutyric Acid CTD PMID:29738703 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964
JBrowse link
G Cyp3a16 cytochrome P450, family 3, subfamily a, polypeptide 16 multiple interactions EXP [[CYP3A11 protein co-treated with CYP3A16 protein co-treated with CYP3A25 protein co-treated with CYP3A41A protein co-treated with CYP3A44 protein co-treated with CYP3A57 protein co-treated with CYP3A59 protein] affects the susceptibility to Dietary Fats] which affects the abundance of 3-Hydroxybutyric Acid CTD PMID:29738703 NCBI chr 5:145,436,309...145,469,740
Ensembl chr 5:145,436,309...145,469,723
JBrowse link
G Cyp3a25 cytochrome P450, family 3, subfamily a, polypeptide 25 multiple interactions EXP [[CYP3A11 protein co-treated with CYP3A16 protein co-treated with CYP3A25 protein co-treated with CYP3A41A protein co-treated with CYP3A44 protein co-treated with CYP3A57 protein co-treated with CYP3A59 protein] affects the susceptibility to Dietary Fats] which affects the abundance of 3-Hydroxybutyric Acid CTD PMID:29738703 NCBI chr 5:145,977,192...146,009,644
Ensembl chr 5:145,977,194...146,009,618
JBrowse link
G Cyp3a41a cytochrome P450, family 3, subfamily a, polypeptide 41A multiple interactions EXP [[CYP3A11 protein co-treated with CYP3A16 protein co-treated with CYP3A25 protein co-treated with CYP3A41A protein co-treated with CYP3A44 protein co-treated with CYP3A57 protein co-treated with CYP3A59 protein] affects the susceptibility to Dietary Fats] which affects the abundance of 3-Hydroxybutyric Acid CTD PMID:29738703 NCBI chr 5:145,694,049...145,720,136
Ensembl chr 5:145,694,049...145,720,136
JBrowse link
G Cyp3a44 cytochrome P450, family 3, subfamily a, polypeptide 44 multiple interactions EXP [[CYP3A11 protein co-treated with CYP3A16 protein co-treated with CYP3A25 protein co-treated with CYP3A41A protein co-treated with CYP3A44 protein co-treated with CYP3A57 protein co-treated with CYP3A59 protein] affects the susceptibility to Dietary Fats] which affects the abundance of 3-Hydroxybutyric Acid CTD PMID:29738703 NCBI chr 5:145,773,983...145,805,891
Ensembl chr 5:145,773,983...145,805,874
JBrowse link
G Cyp3a57 cytochrome P450, family 3, subfamily a, polypeptide 57 multiple interactions EXP [[CYP3A11 protein co-treated with CYP3A16 protein co-treated with CYP3A25 protein co-treated with CYP3A41A protein co-treated with CYP3A44 protein co-treated with CYP3A57 protein co-treated with CYP3A59 protein] affects the susceptibility to Dietary Fats] which affects the abundance of 3-Hydroxybutyric Acid CTD PMID:29738703 NCBI chr 5:145,345,149...145,390,926
Ensembl chr 5:145,345,279...145,390,926
JBrowse link
G Cyp3a59 cytochrome P450, family 3, subfamily a, polypeptide 59 multiple interactions EXP [[CYP3A11 protein co-treated with CYP3A16 protein co-treated with CYP3A25 protein co-treated with CYP3A41A protein co-treated with CYP3A44 protein co-treated with CYP3A57 protein co-treated with CYP3A59 protein] affects the susceptibility to Dietary Fats] which affects the abundance of 3-Hydroxybutyric Acid CTD PMID:29738703 NCBI chr 5:146,079,208...146,114,978
Ensembl chr 5:146,079,257...146,113,287
JBrowse link
G Ercc6 excision repair cross-complementing rodent repair deficiency, complementation group 6 multiple interactions
decreases abundance
ISO
EXP
3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A]; 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased expression of SIRT1 protein]; 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased expression of UCP2 protein]; 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]; 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in increased acetylation of TP53 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]]
ERCC6 gene mutant form results in decreased abundance of 3-Hydroxybutyric Acid
Dietary Fats inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of 3-Hydroxybutyric Acid]
CTD PMID:25440059 NCBI chr14:32,513,291...32,580,990
Ensembl chr14:32,513,521...32,580,990
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions EXP 3-Hydroxybutyric Acid promotes the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased expression of GPT protein] CTD PMID:31332890 NCBI chr15:76,696,726...76,699,675
Ensembl chr15:76,695,716...76,699,686
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 increases secretion ISO HMGCS2 protein results in increased secretion of 3-Hydroxybutyric Acid CTD PMID:27816970 NCBI chr 3:98,280,431...98,310,738
Ensembl chr 3:98,280,435...98,310,738
JBrowse link
G Il6 interleukin 6 multiple interactions EXP 3-Hydroxybutyric Acid promotes the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased expression of IL6 protein] CTD PMID:31332890 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions EXP [NFE2L2 protein mutant form co-treated with Streptozocin] results in increased abundance of 3-Hydroxybutyric Acid CTD PMID:20086057 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased abundance of 3-Hydroxybutyric Acid CTD PMID:20404010 NCBI chr15:85,734,910...85,806,851
Ensembl chr15:85,734,983...85,802,819
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased expression of SIRT1 protein] CTD PMID:25440059 NCBI chr10:63,319,005...63,339,035
Ensembl chr10:63,319,005...63,381,704
JBrowse link
G Slc13a5 solute carrier family 13 (sodium-dependent citrate transporter), member 5 decreases abundance ISO SLC13A5 protein results in decreased abundance of 3-Hydroxybutyric Acid CTD PMID:32634519 NCBI chr11:72,241,990...72,267,295
Ensembl chr11:72,241,989...72,267,222
JBrowse link
G Snca synuclein, alpha multiple interactions ISO 3-Hydroxybutyric Acid inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone]; 3-Hydroxybutyric Acid promotes the reaction [ursodoxicoltaurine inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone]] CTD PMID:16239214 NCBI chr 6:60,731,573...60,829,855
Ensembl chr 6:60,731,575...60,829,855
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP 3-Hydroxybutyric Acid promotes the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased expression of TNF protein] CTD PMID:31332890 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in increased acetylation of TP53 protein] CTD PMID:25440059 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) multiple interactions ISO 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased expression of UCP2 protein] CTD PMID:25440059 NCBI chr 7:100,493,337...100,499,629
Ensembl chr 7:100,493,337...100,502,020
JBrowse link
3-hydroxyisovaleric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO [Dexamethasone co-treated with beta-hydroxyisovaleric acid] results in increased phosphorylation of AKT1 protein CTD PMID:24124592 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Fbxo32 F-box protein 32 increases expression
multiple interactions
ISO beta-hydroxyisovaleric acid results in increased expression of FBXO32 mRNA
beta-hydroxyisovaleric acid inhibits the reaction [Dexamethasone results in increased expression of FBXO32 mRNA]
CTD PMID:24124592 NCBI chr15:58,175,879...58,214,892
Ensembl chr15:58,175,879...58,214,932
JBrowse link
G Usp16 ubiquitin specific peptidase 16 increases expression ISO beta-hydroxyisovaleric acid results in increased expression of USP16 mRNA CTD PMID:24124592 NCBI chr16:87,454,985...87,483,515
Ensembl chr16:87,454,703...87,483,517
JBrowse link
G Usp2 ubiquitin specific peptidase 2 increases expression ISO beta-hydroxyisovaleric acid results in increased expression of USP2 mRNA CTD PMID:24124592 NCBI chr 9:44,067,021...44,095,627
Ensembl chr 9:44,067,021...44,095,627
JBrowse link
G Usp28 ubiquitin specific peptidase 28 increases expression ISO beta-hydroxyisovaleric acid results in increased expression of USP28 mRNA CTD PMID:24124592 NCBI chr 9:48,985,319...49,042,517
Ensembl chr 9:48,985,375...49,042,517
JBrowse link
3-hydroxypyruvic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2, mitochondrial multiple interactions ISO [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to hydroxypyruvic acid CTD PMID:21376711 NCBI chr 5:121,566,027...121,593,824
Ensembl chr 5:121,566,027...121,593,824
JBrowse link
G Cat catalase decreases response to substance ISO CAT protein results in decreased susceptibility to hydroxypyruvic acid CTD PMID:21376711 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
atropine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 multiple interactions
decreases activity
ISO Atropine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Atropine results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 2:69,238,282...69,342,616
Ensembl chr 2:69,238,282...69,342,616
JBrowse link
G Abl1 c-abl oncogene 1, non-receptor tyrosine kinase multiple interactions ISO [Parathion co-treated with Atropine] results in increased expression of ABL1 mRNA CTD PMID:17390078 NCBI chr 2:31,688,244...31,807,093
Ensembl chr 2:31,688,376...31,804,227
JBrowse link
G Ache acetylcholinesterase multiple interactions ISO
EXP
Atropine inhibits the reaction [[Organophosphorus Compounds results in decreased activity of ACHE protein] which results in increased abundance of Acetylcholine]; Atropine inhibits the reaction [Carbachol results in increased metabolism of and results in increased secretion of ACHE protein]; Atropine inhibits the reaction [Paraoxon results in increased expression of ACHE protein]
[Atropine co-treated with Obidoxime Chloride] inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of ACHE protein; [Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein; [pralidoxime co-treated with Atropine] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; [tariquidar co-treated with asoxime chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; Atropine inhibits the reaction [Methyl Parathion results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [[Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [[Atropine co-treated with Curcumin] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]]
[1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [[1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide co-treated with cucurbit(7)uril] co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; Atropine inhibits the reaction [Sarin results in decreased activity of ACHE protein]; Atropine promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; Atropine promotes the reaction [haloxon results in increased phosphorylation of ACHE protein]; Atropine promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein]
CTD PMID:2241428 PMID:10421444 PMID:17963125 PMID:20105433 PMID:21600273 PMID:21787676 PMID:22783142 PMID:23047022 PMID:24881594 PMID:26751814 PMID:31794810 NCBI chr 5:137,288,247...137,294,466
Ensembl chr 5:137,287,519...137,294,466
JBrowse link
G Adcy5 adenylate cyclase 5 increases response to substance EXP ADCY5 protein results in increased susceptibility to Atropine CTD PMID:12869393 NCBI chr16:35,154,494...35,305,743
Ensembl chr16:35,154,877...35,305,738
JBrowse link
G Aqp5 aquaporin 5 multiple interactions EXP Atropine inhibits the reaction [Pilocarpine affects the localization of AQP5 protein] CTD PMID:26208470 NCBI chr15:99,591,028...99,594,829
Ensembl chr15:99,590,782...99,594,829
JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the expression of BAX mRNA] CTD PMID:21971501 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcar1 breast cancer anti-estrogen resistance 1 multiple interactions ISO Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]] CTD PMID:10537051 NCBI chr 8:111,710,474...111,743,849
Ensembl chr 8:111,710,474...111,743,809
JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO [Atropine co-treated with pralidoxime] results in decreased expression of BCHE protein; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of BCHE protein
[BCHE protein co-treated with asoxime chloride co-treated with pro-diazepam co-treated with Atropine] results in decreased susceptibility to VX
CTD PMID:17963125 PMID:22981459 NCBI chr 3:73,635,805...73,708,436
Ensembl chr 3:73,635,808...73,708,415
JBrowse link
G Bdkrb2 bradykinin receptor, beta 2 multiple interactions EXP BDKRB2 affects the susceptibility to [Propranolol co-treated with Atropine] CTD PMID:10614985 NCBI chr12:105,563,172...105,595,244
Ensembl chr12:105,563,226...105,595,237
JBrowse link
G Bmp6 bone morphogenetic protein 6 multiple interactions ISO Atropine inhibits the reaction [Carbon Tetrachloride results in increased expression of BMP6 mRNA] CTD PMID:18472332 NCBI chr13:38,345,716...38,500,314
Ensembl chr13:38,345,107...38,500,302
JBrowse link
G Cacna1e calcium channel, voltage-dependent, R type, alpha 1E subunit multiple interactions ISO Atropine inhibits the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]] CTD PMID:12663092 NCBI chr 1:154,390,806...154,884,785
Ensembl chr 1:154,390,731...154,884,501
JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha affects activity ISO Atropine affects the activity of CALCA protein CTD PMID:7906887 PMID:10075105 NCBI chr 7:114,625,981...114,636,910
Ensembl chr 7:114,631,478...114,636,357
JBrowse link
G Casp3 caspase 3 increases expression ISO Atropine results in increased expression of CASP3 mRNA CTD PMID:19815060 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Ccl5 chemokine (C-C motif) ligand 5 multiple interactions EXP [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 protein] CTD PMID:22245128 NCBI chr11:83,525,778...83,530,518
Ensembl chr11:83,525,778...83,530,518
JBrowse link
G Ccna1 cyclin A1 increases expression
multiple interactions
ISO Atropine results in increased expression of CCNA1 mRNA
[Parathion co-treated with Atropine] results in increased expression of CCNA1 mRNA
CTD PMID:17390078 NCBI chr 3:55,045,469...55,057,634
Ensembl chr 3:55,045,469...55,055,501
JBrowse link
G Ccnd3 cyclin D3 multiple interactions ISO [Parathion co-treated with Atropine] results in increased expression of CCND3 mRNA CTD PMID:17390078 NCBI chr17:47,505,051...47,599,689
Ensembl chr17:47,505,051...47,599,691
JBrowse link
G Ccne1 cyclin E1 increases expression
multiple interactions
ISO Atropine results in increased expression of CCNE1 mRNA
[Parathion co-treated with Atropine] results in increased expression of CCNE1 mRNA
CTD PMID:17390078 NCBI chr 7:38,097,984...38,107,490
Ensembl chr 7:38,097,984...38,107,534
JBrowse link
G Ccne2 cyclin E2 multiple interactions
increases expression
ISO [Parathion co-treated with Atropine] results in increased expression of CCNE2 mRNA
Atropine results in increased expression of CCNE2 mRNA
CTD PMID:17390078 NCBI chr 4:11,190,433...11,204,779
Ensembl chr 4:11,191,351...11,204,779
JBrowse link
G Cd40 CD40 antigen multiple interactions ISO Atropine inhibits the reaction [Carbachol results in increased expression of CD40 protein] CTD PMID:16879495 NCBI chr 2:165,055,614...165,071,654
Ensembl chr 2:165,055,627...165,072,948
JBrowse link
G Cdc20 cell division cycle 20 multiple interactions
increases expression
ISO [Parathion co-treated with Atropine] results in increased expression of CDC20 mRNA
Atropine results in increased expression of CDC20 mRNA
CTD PMID:17390078 NCBI chr 4:118,432,901...118,437,343
Ensembl chr 4:118,432,901...118,437,352
JBrowse link
G Cdc6 cell division cycle 6 multiple interactions ISO [Parathion co-treated with Atropine] results in increased expression of CDC6 mRNA CTD PMID:17390078 NCBI chr11:98,907,709...98,923,942
Ensembl chr11:98,907,801...98,923,940
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions
increases expression
ISO [Parathion co-treated with Atropine] results in increased expression of CDK1 mRNA
Atropine results in increased expression of CDK1 mRNA
CTD PMID:17390078 NCBI chr10:69,335,146...69,352,912
Ensembl chr10:69,335,146...69,352,938
JBrowse link
G Ces1d carboxylesterase 1D multiple interactions ISO Atropine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate] CTD PMID:9311626 NCBI chr 8:93,166,072...93,197,804
Ensembl chr 8:93,166,068...93,197,838
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1, CNS multiple interactions
decreases activity
EXP
ISO
Atropine binds to and results in decreased activity of CHRM1 protein; Atropine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]
Atropine results in decreased activity of CHRM1 protein
Atropine affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]
CTD PMID:16439611 PMID:18316702 PMID:31830555 NCBI chr19:8,664,005...8,683,606
Ensembl chr19:8,663,789...8,683,587
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2, cardiac multiple interactions ISO Atropine binds to and results in decreased activity of CHRM2 protein CTD PMID:15140916 NCBI chr 6:36,387,991...36,528,638
Ensembl chr 6:36,388,084...36,528,414
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3, cardiac multiple interactions
decreases activity
ISO Atropine binds to and results in decreased activity of CHRM3 protein; Atropine inhibits the reaction [Carbachol results in increased activity of CHRM3 protein]
Atropine results in decreased activity of CHRM3 protein
CTD PMID:15140916 PMID:20708676 PMID:31830555 NCBI chr13:9,875,486...10,361,062
Ensembl chr13:9,875,486...10,360,847
JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 multiple interactions
affects binding
ISO [WIN 62577 co-treated with Quinuclidinyl Benzilate] inhibits the reaction [Atropine binds to CHRM4 protein] CTD PMID:16709648 NCBI chr 2:91,922,189...91,929,835
Ensembl chr 2:91,927,249...91,928,688
JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 multiple interactions ISO Atropine inhibits the reaction [Acetylcholine results in increased activity of CHRM5 protein] CTD PMID:31323226 NCBI chr 2:112,478,733...112,536,361
Ensembl chr 2:112,479,171...112,480,769
JBrowse link
G Chrna4 cholinergic receptor, nicotinic, alpha polypeptide 4 multiple interactions
affects binding
ISO Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 protein]]
Atropine binds to [CHRNA4 protein binds to CHRNB2 protein]
CTD PMID:15733544 PMID:21791372 NCBI chr 2:181,022,311...181,043,579
Ensembl chr 2:181,018,380...181,043,546
JBrowse link
G Chrnb2 cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) affects binding
multiple interactions
ISO Atropine binds to [CHRNA4 protein binds to CHRNB2 protein]
Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 protein]]
Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
CTD PMID:15733544 PMID:21791372 NCBI chr 3:89,753,448...89,764,632
Ensembl chr 3:89,746,195...89,764,632
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of CREB1 protein] CTD PMID:21971501 NCBI chr 1:64,532,794...64,604,548
Ensembl chr 1:64,532,645...64,604,548
JBrowse link
G Crh corticotropin releasing hormone multiple interactions ISO Atropine inhibits the reaction [acephate results in increased expression of CRH mRNA]; Atropine inhibits the reaction [acephate results in increased secretion of CRH protein]; Atropine inhibits the reaction [methamidophos results in increased expression of CRH mRNA]; Atropine inhibits the reaction [methamidophos results in increased secretion of CRH protein]
[Atropine co-treated with SR 140333 co-treated with SR 48968] results in decreased activity of CRH protein
CTD PMID:12039681 PMID:12906840 NCBI chr 3:19,693,401...19,695,396
Ensembl chr 3:19,693,401...19,695,396
JBrowse link
G Ctnnb1 catenin (cadherin associated protein), beta 1 multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of CTNNB1 protein mutant form]; Atropine inhibits the reaction [Parathion results in increased expression of CTNNB1 protein] CTD PMID:17390078 NCBI chr 9:120,933,400...120,960,507
Ensembl chr 9:120,929,216...120,960,507
JBrowse link
G Cxcl3 chemokine (C-X-C motif) ligand 3 multiple interactions EXP [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 protein] CTD PMID:22245128 NCBI chr 5:90,786,101...90,788,093
Ensembl chr 5:90,786,103...90,789,600
JBrowse link
G Dvl2 dishevelled segment polarity protein 2 multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of DVL2 protein] CTD PMID:17390078 NCBI chr11:70,000,592...70,010,109
Ensembl chr11:70,000,595...70,012,301
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO EDN1 protein results in decreased activity of [Atropine co-treated with Histamine] CTD PMID:12906840 NCBI chr13:42,301,476...42,307,990
Ensembl chr13:42,301,476...42,307,990
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of EGFR protein] CTD PMID:17390078 NCBI chr11:16,752,203...16,913,907
Ensembl chr11:16,752,203...16,918,158
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR1 mRNA] CTD PMID:7968354 NCBI chr18:34,861,207...34,864,956
Ensembl chr18:34,859,823...34,864,984
JBrowse link
G Egr2 early growth response 2 multiple interactions ISO Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA] CTD PMID:7968354 NCBI chr10:67,534,469...67,542,188
Ensembl chr10:67,535,475...67,542,188
JBrowse link
G Ezr ezrin multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of EZR protein] CTD PMID:17390078 NCBI chr17:6,738,131...6,782,780
Ensembl chr17:6,738,041...6,782,784
JBrowse link
G F2 coagulation factor II multiple interactions EXP [Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in decreased expression of F2 mRNA; [Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in increased activity of F2 protein CTD PMID:30515700 NCBI chr 2:91,612,397...91,636,457
Ensembl chr 2:91,625,320...91,636,414
JBrowse link
G F2r coagulation factor II (thrombin) receptor multiple interactions EXP [Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in increased expression of F2R protein CTD PMID:30515700 NCBI chr13:95,601,780...95,618,466
Ensembl chr13:95,601,803...95,618,487
JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression
multiple interactions
ISO Atropine results in increased expression of FOS protein
Atropine inhibits the reaction [Paraoxon results in increased expression of FOS mRNA]
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased expression of FOS protein]; Atropine inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]
CTD PMID:7968354 PMID:8281324 PMID:21787676 PMID:21971501 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Ghrl ghrelin multiple interactions ISO Atropine inhibits the reaction [[Pentobarbital co-treated with L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide] results in increased expression of GHRL protein] CTD PMID:16959836 NCBI chr 6:113,716,119...113,719,911
Ensembl chr 6:113,716,119...113,719,880
JBrowse link
G Glra1 glycine receptor, alpha 1 subunit multiple interactions ISO Atropine binds to and results in decreased activity of GLRA1 protein CTD PMID:15081878 NCBI chr11:55,514,239...55,608,198
Ensembl chr11:55,514,238...55,608,198
JBrowse link
G Grm4 glutamate receptor, metabotropic 4 multiple interactions ISO Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] CTD PMID:18171729 NCBI chr17:27,422,387...27,513,826
Ensembl chr17:27,422,387...27,521,403
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of ICAM1 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of ICAM1 protein] CTD PMID:22245128 NCBI chr 9:21,015,940...21,028,814
Ensembl chr 9:21,015,985...21,028,817
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of IL1B mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of IL1B protein] CTD PMID:22245128 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 mRNA]; [Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 protein] CTD PMID:22245128 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Jun jun proto-oncogene multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of JUN protein] CTD PMID:21971501 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222
JBrowse link
G Junb jun B proto-oncogene multiple interactions ISO Atropine inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA] CTD PMID:7968354 NCBI chr 8:84,976,909...84,978,748
Ensembl chr 8:84,974,484...84,978,718
Ensembl chr 8:84,974,484...84,978,718
JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 multiple interactions ISO Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] CTD PMID:18171729 NCBI chr 2:55,411,798...55,598,145
Ensembl chr 2:55,435,970...55,598,145
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of KIT protein] CTD PMID:17390078 NCBI chr 5:75,574,987...75,656,722
Ensembl chr 5:75,574,916...75,656,722
JBrowse link
G Ltf lactotransferrin multiple interactions ISO Atropine inhibits the reaction [methylcholine results in increased secretion of LTF protein] CTD PMID:11112886 NCBI chr 9:111,019,292...111,042,766
Ensembl chr 9:111,019,271...111,042,767
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK1 protein] CTD PMID:21971501 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk14 mitogen-activated protein kinase 14 multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK14 protein] CTD PMID:21971501 NCBI chr17:28,691,342...28,748,405
Ensembl chr17:28,691,329...28,748,406
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK3 protein] CTD PMID:21971501 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK8 protein] CTD PMID:21971501 NCBI chr14:33,377,898...33,447,353
Ensembl chr14:33,377,898...33,447,158
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 multiple interactions
increases expression
ISO [Parathion co-treated with Atropine] results in increased expression of MCM4 mRNA
Atropine results in increased expression of MCM4 mRNA
CTD PMID:17390078 NCBI chr16:15,623,897...15,637,400
Ensembl chr16:15,623,897...15,637,400
JBrowse link
G Mcm6 minichromosome maintenance complex component 6 increases expression
multiple interactions
ISO Atropine results in increased expression of MCM6 mRNA
[Parathion co-treated with Atropine] results in increased expression of MCM6 mRNA
CTD PMID:17390078 NCBI chr 1:128,331,575...128,359,705
Ensembl chr 1:128,331,590...128,359,664
JBrowse link
G Nefh neurofilament, heavy polypeptide affects expression ISO Atropine affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr11:4,938,754...4,948,064
Ensembl chr11:4,938,754...4,948,064
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 increases expression ISO Atropine results in increased expression of NLRP3 mRNA CTD PMID:28138970 NCBI chr11:59,541,569...59,566,955
Ensembl chr11:59,541,568...59,566,956
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO Atropine inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; Atropine inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA] CTD PMID:15610444 PMID:16944022 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Notch4 notch 4 multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of NOTCH4 protein] CTD PMID:17390078 NCBI chr17:34,564,286...34,588,543
Ensembl chr17:34,564,268...34,588,503
JBrowse link
G Nppa natriuretic peptide type A affects activity ISO Atropine affects the activity of NPPA protein modified form CTD PMID:1363893 NCBI chr 4:148,000,722...148,002,074
Ensembl chr 4:148,000,722...148,002,079
JBrowse link
G Oprl1 opioid receptor-like 1 multiple interactions ISO Atropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein] CTD PMID:12007927 NCBI chr 2:181,715,000...181,720,985
Ensembl chr 2:181,715,016...181,720,985
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Atropine inhibits the reaction [Malathion results in increased expression of PCNA]; Atropine inhibits the reaction [Parathion results in increased expression of PCNA] CTD PMID:12762645 NCBI chr 2:132,249,286...132,253,180
Ensembl chr 2:132,249,162...132,253,314
JBrowse link
G Pnoc prepronociceptin multiple interactions ISO Atropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein] CTD PMID:12007927 NCBI chr14:65,400,673...65,425,564
Ensembl chr14:65,400,673...65,425,472
JBrowse link
G Pomc pro-opiomelanocortin-alpha multiple interactions ISO Atropine inhibits the reaction [Acetylcholine results in increased expression of POMC protein] CTD PMID:7588217 NCBI chr12:3,954,945...3,960,643
Ensembl chr12:3,954,951...3,960,642
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP [Atropine co-treated with Glucose] binds to PPARA protein; Atropine inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]] CTD PMID:18812576 NCBI chr15:85,734,910...85,806,851
Ensembl chr15:85,734,983...85,802,819
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Atropine affects the reaction [Indomethacin results in increased expression of PTGS2]; Atropine inhibits the reaction [Indomethacin results in increased expression of PTGS2 mRNA]; Atropine inhibits the reaction [Indomethacin results in increased expression of PTGS2]; Atropine inhibits the reaction [SC 560 results in increased expression of PTGS2 mRNA] CTD PMID:15104355 PMID:15610444 PMID:16259740 PMID:16804302 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Ptk2 PTK2 protein tyrosine kinase 2 multiple interactions ISO Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein]] CTD PMID:10537051 NCBI chr15:73,205,102...73,423,820
Ensembl chr15:73,205,102...73,423,280
JBrowse link
G Pxn paxillin multiple interactions ISO Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]] CTD PMID:10537051 NCBI chr 5:115,491,970...115,555,987
Ensembl chr 5:115,506,676...115,555,987
JBrowse link
G Rac3 Rac family small GTPase 3 multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of RAC3 protein] CTD PMID:17390078 NCBI chr11:120,721,468...120,723,969
Ensembl chr11:120,721,470...120,723,969
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of RELA protein] CTD PMID:21971501 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of RHOA protein] CTD PMID:17390078 NCBI chr 9:108,306,160...108,337,943
Ensembl chr 9:108,306,129...108,337,934
JBrowse link
G Slc22a1 solute carrier family 22 (organic cation transporter), member 1 multiple interactions ISO Atropine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Atropine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:16263091 PMID:21641380 NCBI chr17:12,648,874...12,675,838
Ensembl chr17:12,648,869...12,675,829
JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO Atropine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Atropine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Atropine inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium] CTD PMID:16263091 PMID:21599003 PMID:23770354 NCBI chr17:12,584,189...12,628,489
Ensembl chr17:12,584,132...12,628,488
JBrowse link
G Slc22a3 solute carrier family 22 (organic cation transporter), member 3 increases uptake
multiple interactions
ISO SLC22A3 protein results in increased uptake of Atropine
Atropine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]
CTD PMID:16263091 NCBI chr17:12,419,972...12,507,704
Ensembl chr17:12,418,960...12,507,704
JBrowse link
G Slc22a4 solute carrier family 22 (organic cation transporter), member 4 multiple interactions ISO Atropine inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium] CTD PMID:21641380 NCBI chr11:53,983,115...54,030,040
Ensembl chr11:53,983,123...54,028,090
JBrowse link
G Slc47a1 solute carrier family 47, member 1 multiple interactions ISO Atropine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr11:61,343,400...61,378,842
Ensembl chr11:61,343,401...61,378,345
JBrowse link
G Slc47a2 solute carrier family 47, member 2 multiple interactions ISO Atropine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr11:61,301,627...61,342,860
Ensembl chr11:61,301,631...61,342,860
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Atropine results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 2:164,354,070...164,356,507
Ensembl chr 2:164,354,070...164,389,095
JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions EXP [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of SOCS3 mRNA] CTD PMID:22245128 NCBI chr11:117,966,079...117,970,336
Ensembl chr11:117,966,079...117,970,047
JBrowse link
G Spn sialophorin increases response to substance EXP SPN protein results in increased susceptibility to Atropine CTD PMID:18711009 NCBI chr 7:127,123,637...127,145,552
Ensembl chr 7:127,132,232...127,137,823
JBrowse link
G Tat tyrosine aminotransferase multiple interactions ISO [Atropine co-treated with Obidoxime Chloride co-treated with Diazepam] inhibits the reaction [Dichlorvos results in increased expression of TAT protein] CTD PMID:7761789 NCBI chr 8:109,986,078...109,999,804
Ensembl chr 8:109,990,437...109,999,803
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Atropine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA] CTD PMID:18472332 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of TNF mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of TNF protein] CTD PMID:22245128 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Trio triple functional domain (PTPRF interacting) multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of TRIO protein] CTD PMID:17390078 NCBI chr15:27,730,649...28,025,848
Ensembl chr15:27,730,651...28,025,848
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO Atropine inhibits the reaction [Malathion results in increased expression of TP53 protein]; Atropine inhibits the reaction [Parathion results in increased expression of TP53 protein] CTD PMID:12762645 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 decreases response to substance EXP TRPA1 gene mutant form results in decreased susceptibility to Atropine CTD PMID:29627347 NCBI chr 1:14,872,644...14,918,862
Ensembl chr 1:14,872,648...14,918,862
JBrowse link
G Tshb thyroid stimulating hormone, beta subunit multiple interactions ISO [pralidoxime co-treated with Atropine] inhibits the reaction [methamidophos results in decreased expression of TSHB protein] CTD PMID:15891268 NCBI chr 3:102,777,398...102,789,082
Ensembl chr 3:102,775,465...102,782,718
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of VCAM1 mRNA] CTD PMID:22245128 NCBI chr 3:116,110,020...116,129,688
Ensembl chr 3:116,109,949...116,129,688
JBrowse link
beta-propiolactone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 decreases response to substance EXP NFE2L2 protein results in decreased susceptibility to Propiolactone CTD PMID:20932822 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
propetamphos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases activity
multiple interactions
EXP
ISO
propetamphos results in decreased activity of CAT protein
[cypermethrin co-treated with propetamphos] results in decreased activity of CAT protein
[propetamphos co-treated with cypermethrin] results in decreased activity of CAT protein
CTD PMID:18214882 PMID:25926273 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Cycs cytochrome c, somatic multiple interactions
increases activity
ISO [propetamphos co-treated with cypermethrin] results in increased activity of CYCS protein
propetamphos results in increased activity of CYCS protein
CTD PMID:25926273 NCBI chr 6:50,562,563...50,566,569
Ensembl chr 6:50,562,563...50,566,538
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases activity
ISO [cypermethrin co-treated with propetamphos] results in increased activity of CYP2E1 protein
propetamphos results in increased activity of CYP2E1 protein
CTD PMID:25926273 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked multiple interactions
decreases activity
ISO [cypermethrin co-treated with propetamphos] results in decreased activity of G6PD protein
propetamphos results in decreased activity of G6PD protein
CTD PMID:25926273 NCBI chr  X:74,409,483...74,428,880
Ensembl chr  X:74,409,483...74,429,194
JBrowse link
scopolamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A decreases expression ISO Scopolamine results in decreased expression of ABCB1 mRNA CTD PMID:12818353 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 increases expression ISO Scopolamine results in increased expression of ABCG1 mRNA CTD PMID:12818353 NCBI chr17:31,057,694...31,117,984
Ensembl chr17:31,057,675...31,117,988
JBrowse link
G Ache acetylcholinesterase multiple interactions
increases expression
affects activity
increases activity
decreases activity
decreases expression
increases response to substance
affects response to substance
ISO
EXP
kangshuai yizhi inhibits the reaction [Scopolamine results in increased activity of ACHE protein]
Scopolamine results in increased expression of ACHE mRNA; Scopolamine results in increased expression of ACHE protein
Scopolamine affects the activity of ACHE protein
Scopolamine results in decreased activity of ACHE protein
Ascorbic Acid inhibits the reaction [Scopolamine results in decreased activity of ACHE protein]; Canagliflozin inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Galantamine inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; stevioside inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Vitamin E inhibits the reaction [Scopolamine results in decreased activity of ACHE protein]
Scopolamine results in decreased expression of ACHE protein
ACHE protein results in increased susceptibility to Scopolamine
7-fluoro-1,3-diphenylisoquinoline-1-amine inhibits the reaction [Scopolamine results in increased expression of ACHE protein]; acanthoside B inhibits the reaction [Scopolamine results in increased expression of ACHE protein]; ajoene inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; chong-myung-tang inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; mangiferin inhibits the reaction [Scopolamine results in decreased expression of ACHE protein]; Piracetam inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Plant Extracts affects the reaction [Scopolamine affects the activity of ACHE protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased expression of ACHE mRNA]; protopanaxadiol inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Serotonin analog inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of ACHE protein]
ACHE affects the susceptibility to Scopolamine
CTD PMID:11814146 PMID:15301936 PMID:18533140 PMID:18672024 PMID:20673844 PMID:20694781 PMID:20871768 PMID:22426032 PMID:26408985 PMID:26434561 PMID:27717698 PMID:28837785 PMID:29133030 PMID:31077737 PMID:32001261 NCBI chr 5:137,288,247...137,294,466
Ensembl chr 5:137,287,519...137,294,466
JBrowse link
G Adora3 adenosine A3 receptor multiple interactions EXP [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein] which results in decreased susceptibility to Scopolamine CTD PMID:12672554 NCBI chr 3:105,904,421...105,908,928
Ensembl chr 3:105,870,858...105,908,926
JBrowse link
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) multiple interactions ISO [AGT protein modified form binds to and results in decreased activity of LNPEP protein] which results in decreased susceptibility to Scopolamine CTD PMID:11707427 NCBI chr 8:124,556,587...124,569,706
Ensembl chr 8:124,556,534...124,569,706
JBrowse link
G Apba1 amyloid beta (A4) precursor protein binding, family A, member 1 increases expression ISO Scopolamine results in increased expression of APBA1 mRNA CTD PMID:12818353 NCBI chr19:23,758,806...23,949,598
Ensembl chr19:23,758,887...23,949,596
JBrowse link
G Aplp2 amyloid beta (A4) precursor-like protein 2 increases expression ISO Scopolamine results in increased expression of APLP2 mRNA CTD PMID:12818353 NCBI chr 9:31,149,557...31,211,848
Ensembl chr 9:31,149,557...31,211,815
JBrowse link
G App amyloid beta (A4) precursor protein decreases cleavage EXP Scopolamine results in decreased cleavage of APP protein CTD PMID:16423497 NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766
JBrowse link
G Arc activity regulated cytoskeletal-associated protein decreases expression ISO Scopolamine results in decreased expression of ARC mRNA CTD PMID:17540011 NCBI chr15:74,669,081...74,672,570
Ensembl chr15:74,669,083...74,672,570
JBrowse link
G Arg2 arginase type II decreases expression ISO Scopolamine results in decreased expression of ARG2 mRNA CTD PMID:12818353 NCBI chr12:79,130,788...79,156,301
Ensembl chr12:79,130,777...79,156,301
JBrowse link
G Arl4d ADP-ribosylation factor-like 4D decreases expression ISO Scopolamine results in decreased expression of ARL4D mRNA CTD PMID:17540011 NCBI chr11:101,665,541...101,667,832
Ensembl chr11:101,665,541...101,667,832
JBrowse link
G Avp arginine vasopressin multiple interactions ISO [[[AVP binds to and results in increased activity of AVPR1A protein] which results in increased abundance of Calcium] which results in increased activity of CHRM1 protein] which results in decreased susceptibility to Scopolamine CTD PMID:11553362 NCBI chr 2:130,580,620...130,582,588
Ensembl chr 2:130,580,620...130,582,554
JBrowse link
G Avpr1a arginine vasopressin receptor 1A multiple interactions ISO [[[AVP binds to and results in increased activity of AVPR1A protein] which results in increased abundance of Calcium] which results in increased activity of CHRM1 protein] which results in decreased susceptibility to Scopolamine CTD PMID:11553362 NCBI chr10:122,448,499...122,453,453
Ensembl chr10:122,448,499...122,453,452
JBrowse link
G Bax BCL2-associated X protein increases expression
multiple interactions
EXP Scopolamine results in increased expression of BAX mRNA; Scopolamine results in increased expression of BAX protein
Plant Extracts inhibits the reaction [Scopolamine results in increased expression of BAX mRNA]
CTD PMID:17120751 PMID:26434561 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcat1 branched chain aminotransferase 1, cytosolic increases expression ISO Scopolamine results in increased expression of BCAT1 mRNA CTD PMID:17540011 NCBI chr 6:144,993,835...145,076,157
Ensembl chr 6:144,993,835...145,076,184
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression EXP Scopolamine results in decreased expression of BCL2 mRNA; Scopolamine results in decreased expression of BCL2 protein CTD PMID:17120751 PMID:26434561 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bdnf brain derived neurotrophic factor multiple interactions
decreases expression
ISO
EXP
Scopolamine inhibits the reaction [Dizocilpine Maleate affects the expression of BDNF mRNA]; Scopolamine inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA]
Scopolamine results in decreased expression of BDNF mRNA; Scopolamine results in decreased expression of BDNF protein
[acanthoside B co-treated with Scopolamine] results in increased expression of BDNF protein; [Tacrine co-treated with Scopolamine] results in increased expression of BDNF protein; Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of BDNF mRNA]; Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]; Melatonin inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]; Plant Extracts inhibits the reaction [Scopolamine results in decreased expression of BDNF mRNA]; Serotonin analog inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]; Tacrine inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]
CTD PMID:8405262 PMID:8635431 PMID:22096544 PMID:26408985 PMID:26434561 PMID:29476728 PMID:31077737 NCBI chr 2:109,674,700...109,727,043
Ensembl chr 2:109,674,700...109,727,007
JBrowse link
G Cacna1d calcium channel, voltage-dependent, L type, alpha 1D subunit increases expression ISO Scopolamine results in increased expression of CACNA1D mRNA CTD PMID:12818353 NCBI chr14:30,039,941...30,491,156
Ensembl chr14:30,039,939...30,491,455
JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2, beta decreases expression ISO Scopolamine results in decreased expression of CAMKK2 mRNA CTD PMID:17540011 NCBI chr 5:122,718,380...122,779,522
Ensembl chr 5:122,731,170...122,779,409
JBrowse link
G Cartpt CART prepropeptide decreases expression ISO Scopolamine results in decreased expression of CARTPT mRNA CTD PMID:17540011 NCBI chr13:99,898,483...99,910,179
Ensembl chr13:99,898,489...99,901,091
JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
EXP Scopolamine results in increased expression of CASP3 mRNA; Scopolamine results in increased expression of CASP3 protein
Plant Extracts inhibits the reaction [Scopolamine results in increased expression of CASP3 mRNA]
CTD PMID:17120751 PMID:26434561 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Cat catalase multiple interactions
increases activity
decreases activity
EXP acanthoside B inhibits the reaction [Scopolamine results in decreased activity of CAT protein]; chong-myung-tang inhibits the reaction [Scopolamine results in decreased activity of CAT protein]; Piracetam inhibits the reaction [Scopolamine results in increased activity of CAT protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased activity of CAT protein]; Tacrine inhibits the reaction [Scopolamine results in decreased activity of CAT protein] CTD PMID:20673844 PMID:27717698 PMID:31077737 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Cd3e CD3 antigen, epsilon polypeptide decreases expression ISO Scopolamine results in decreased expression of CD3E mRNA CTD PMID:17540011 NCBI chr 9:44,998,735...45,009,663
Ensembl chr 9:44,998,740...45,009,627
JBrowse link
G Cdkl4 cyclin-dependent kinase-like 4 increases expression ISO Scopolamine results in increased expression of CDKL4 mRNA CTD PMID:17540011 NCBI chr17:80,523,550...80,577,813
Ensembl chr17:80,523,550...80,577,813
JBrowse link
G Chat choline acetyltransferase decreases activity
multiple interactions
ISO
EXP
Scopolamine results in decreased activity of CHAT protein
protopanaxadiol inhibits the reaction [Scopolamine results in decreased activity of CHAT protein]; Serotonin analog inhibits the reaction [Scopolamine results in decreased activity of CHAT protein]
kangshuai yizhi inhibits the reaction [Scopolamine results in decreased activity of CHAT protein]
CTD PMID:20694781 PMID:26408985 PMID:29133030 NCBI chr14:32,408,203...32,465,909
Ensembl chr14:32,408,203...32,465,989
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1, CNS multiple interactions
decreases expression
increases expression
ISO
EXP
[[[AVP binds to and results in increased activity of AVPR1A protein] which results in increased abundance of Calcium] which results in increased activity of CHRM1 protein] which results in decreased susceptibility to Scopolamine; Canagliflozin affects the reaction [Scopolamine results in decreased expression of CHRM1 protein]
Scopolamine results in increased expression of CHRM1 mRNA
7-fluoro-1,3-diphenylisoquinoline-1-amine inhibits the reaction [Scopolamine results in decreased expression of CHRM1 protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased expression of CHRM1 mRNA]
CTD PMID:11553362 PMID:26434561 PMID:28837785 PMID:32001261 NCBI chr19:8,664,005...8,683,606
Ensembl chr19:8,663,789...8,683,587
JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 increases response to substance EXP CHRM4 protein results in increased susceptibility to Scopolamine CTD PMID:12729838 NCBI chr 2:91,922,189...91,929,835
Ensembl chr 2:91,927,249...91,928,688
JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 decreases response to substance EXP CHRM5 protein results in decreased susceptibility to Scopolamine CTD PMID:13679217 NCBI chr 2:112,478,733...112,536,361
Ensembl chr 2:112,479,171...112,480,769
JBrowse link
G Chrna4 cholinergic receptor, nicotinic, alpha polypeptide 4 affects binding
multiple interactions
ISO Scopolamine binds to [CHRNA4 protein binds to CHRNB2 protein]
Scopolamine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
CTD PMID:15733544 NCBI chr 2:181,022,311...181,043,579
Ensembl chr 2:181,018,380...181,043,546
JBrowse link
G Chrnb2 cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) affects binding
multiple interactions
ISO Scopolamine binds to [CHRNA4 protein binds to CHRNB2 protein]
Scopolamine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
CTD PMID:15733544 NCBI chr 3:89,753,448...89,764,632
Ensembl chr 3:89,746,195...89,764,632
JBrowse link
G Coch cochlin decreases expression ISO Scopolamine results in decreased expression of COCH mRNA CTD PMID:12818353 NCBI chr12:51,593,283...51,606,619
Ensembl chr12:51,593,341...51,605,771
JBrowse link
G Coro1b coronin, actin binding protein 1B increases expression ISO Scopolamine results in increased expression of CORO1B mRNA CTD PMID:12818353 NCBI chr19:4,148,611...4,154,035
Ensembl chr19:4,148,619...4,154,035
JBrowse link
G Cox5b cytochrome c oxidase subunit 5B increases expression ISO Scopolamine results in increased expression of COX5B mRNA CTD PMID:12818353 NCBI chr 1:36,691,487...36,693,388
Ensembl chr 1:36,691,449...36,693,681
JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases phosphorylation
multiple interactions
EXP Scopolamine results in decreased phosphorylation of CREB1 protein
acanthoside B inhibits the reaction [Scopolamine results in decreased phosphorylation of CREB1 protein]; Serotonin analog inhibits the reaction [Scopolamine results in decreased phosphorylation of CREB1 protein]; Tacrine inhibits the reaction [Scopolamine results in decreased phosphorylation of CREB1 protein]
CTD PMID:26408985 PMID:31077737 NCBI chr 1:64,532,794...64,604,548
Ensembl chr 1:64,532,645...64,604,548
JBrowse link
G Cryab crystallin, alpha B increases expression ISO Scopolamine results in increased expression of CRYAB mRNA CTD PMID:17540011 NCBI chr 9:50,745,951...50,756,636
Ensembl chr 9:50,751,325...50,756,636
JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) multiple interactions
decreases response to substance
EXP IL1RN protein inhibits the reaction [CSF2 protein results in decreased susceptibility to Scopolamine] CTD PMID:8877002 NCBI chr11:54,247,270...54,249,899
Ensembl chr11:54,247,271...54,249,667
JBrowse link
G Cxcr5 chemokine (C-X-C motif) receptor 5 decreases expression ISO Scopolamine results in decreased expression of CXCR5 mRNA CTD PMID:12818353 NCBI chr 9:44,511,787...44,526,444
Ensembl chr 9:44,511,787...44,561,877
JBrowse link
G Ddc dopa decarboxylase decreases expression ISO Scopolamine results in decreased expression of DDC mRNA CTD PMID:17540011 NCBI chr11:11,814,101...11,898,144
Ensembl chr11:11,814,101...11,898,144
JBrowse link
G Dguok deoxyguanosine kinase increases expression ISO Scopolamine results in increased expression of DGUOK mRNA CTD PMID:17540011 NCBI chr 6:83,480,214...83,506,969
Ensembl chr 6:83,480,217...83,506,969
JBrowse link
G Dio2 deiodinase, iodothyronine, type II increases expression ISO Scopolamine results in increased expression of DIO2 mRNA CTD PMID:12818353 NCBI chr12:90,724,552...90,739,038
Ensembl chr12:90,724,552...90,738,438
JBrowse link
G Dusp5 dual specificity phosphatase 5 decreases expression ISO Scopolamine results in decreased expression of DUSP5 mRNA CTD PMID:17540011 NCBI chr19:53,529,145...53,541,809
Ensembl chr19:53,529,109...53,542,431
JBrowse link
G Dusp6 dual specificity phosphatase 6 decreases expression ISO Scopolamine results in decreased expression of DUSP6 mRNA CTD PMID:17540011 NCBI chr10:99,263,231...99,267,489
Ensembl chr10:99,263,231...99,267,489
JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO Scopolamine results in decreased expression of EGFR mRNA CTD PMID:12818353 NCBI chr11:16,752,203...16,913,907
Ensembl chr11:16,752,203...16,918,158
JBrowse link
G Egr1 early growth response 1 multiple interactions
decreases expression
ISO
EXP
[Scopolamine co-treated with 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine] results in increased expression of EGR1 mRNA; Scopolamine affects the reaction [SK&F 82958 results in increased expression of EGR1 mRNA]
Donepezil inhibits the reaction [Scopolamine results in decreased expression of EGR1 protein]; protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of EGR1 protein]
Scopolamine results in decreased expression of EGR1 mRNA
CTD PMID:8861055 PMID:17540011 PMID:29133030 NCBI chr18:34,861,207...34,864,956
Ensembl chr18:34,859,823...34,864,984
JBrowse link
G Egr2 early growth response 2 decreases expression ISO Scopolamine results in decreased expression of EGR2 mRNA CTD PMID:17540011 NCBI chr10:67,534,469...67,542,188
Ensembl chr10:67,535,475...67,542,188
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha increases expression ISO Scopolamine results in increased expression of EIF2S1 mRNA CTD PMID:12818353 NCBI chr12:78,862,072...78,887,010
Ensembl chr12:78,861,819...78,887,010
JBrowse link
G Eml1 echinoderm microtubule associated protein like 1 decreases expression ISO Scopolamine results in decreased expression of EML1 mRNA CTD PMID:17540011 NCBI chr12:108,371,002...108,539,576
Ensembl chr12:108,370,957...108,539,617
JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions
decreases expression
increases expression
ISO
EXP
[Scopolamine co-treated with 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine] results in increased expression of FOS mRNA; Physostigmine inhibits the reaction [Scopolamine promotes the reaction [SK&F 82958 results in increased expression of FOS mRNA]]; Ro4368554 inhibits the reaction [Scopolamine results in increased expression of FOS protein]; Scopolamine affects the reaction [SK&F 82958 results in increased expression of FOS mRNA]; Scopolamine inhibits the reaction [Haloperidol results in increased expression of FOS protein]; Scopolamine promotes the reaction [SK&F 82958 results in increased expression of FOS mRNA]
Scopolamine results in decreased expression of FOS protein
Donepezil inhibits the reaction [Scopolamine results in decreased expression of FOS protein]; protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of FOS protein]
Scopolamine results in decreased expression of FOS mRNA
CTD PMID:1393566 PMID:8281324 PMID:8861055 PMID:11337201 PMID:17540011 PMID:17920665 PMID:29133030 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Gabbr1 gamma-aminobutyric acid (GABA) B receptor, 1 increases expression ISO Scopolamine results in increased expression of GABBR1 mRNA CTD PMID:17540011 NCBI chr17:37,045,966...37,074,305
Ensembl chr17:37,045,966...37,075,067
JBrowse link
G Gap43 growth associated protein 43 multiple interactions
decreases expression
ISO Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of GAP43 protein]; withanone inhibits the reaction [Scopolamine results in decreased expression of GAP43 protein] CTD PMID:22096544 NCBI chr16:42,248,552...42,340,651
Ensembl chr16:42,248,442...42,340,651
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression
multiple interactions
EXP Scopolamine results in decreased expression of GFAP mRNA; Scopolamine results in decreased expression of GFAP protein
Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of GFAP mRNA]; Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of GFAP protein]; withanone inhibits the reaction [Scopolamine results in decreased expression of GFAP protein]
CTD PMID:22096544 NCBI chr11:102,887,336...102,897,200
Ensembl chr11:102,887,336...102,900,912
JBrowse link
G Gjb2 gap junction protein, beta 2 increases expression ISO Scopolamine results in increased expression of GJB2 mRNA CTD PMID:17540011 NCBI chr14:57,098,602...57,104,702
Ensembl chr14:57,098,600...57,104,702
JBrowse link
G Gpc3 glypican 3 decreases expression ISO Scopolamine results in decreased expression of GPC3 mRNA CTD PMID:12818353 NCBI chr  X:52,272,426...52,613,974
Ensembl chr  X:52,272,426...52,613,950
JBrowse link
G Grm4 glutamate receptor, metabotropic 4 multiple interactions ISO Scopolamine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] CTD PMID:18171729 NCBI chr17:27,422,387...27,513,826
Ensembl chr17:27,422,387...27,521,403
JBrowse link
G Gsr glutathione reductase decreases activity
multiple interactions
EXP Scopolamine results in decreased activity of GSR protein
Serotonin analog inhibits the reaction [Scopolamine results in decreased activity of GSR protein]; Tacrine inhibits the reaction [Scopolamine results in decreased activity of GSR protein]
CTD PMID:26408985 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163
JBrowse link
G Gypc glycophorin C decreases expression ISO Scopolamine results in decreased expression of GYPC mRNA CTD PMID:17540011 NCBI chr18:32,528,320...32,560,034
Ensembl chr18:32,528,322...32,560,034
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
EXP 7-fluoro-1,3-diphenylisoquinoline-1-amine inhibits the reaction [Scopolamine results in increased expression of HMOX1 protein] CTD PMID:32001261 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Homer1 homer scaffolding protein 1 decreases expression ISO Scopolamine results in decreased expression of HOMER1 mRNA CTD PMID:17540011 NCBI chr13:93,303,757...93,405,129
Ensembl chr13:93,299,635...93,405,129
JBrowse link
G Hrh1 histamine receptor H1 multiple interactions ISO [Histamine binds to and results in increased activity of HRH1 protein] which results in decreased susceptibility to Scopolamine; Pyrilamine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in decreased susceptibility to Scopolamine] CTD PMID:19215234 NCBI chr 6:114,397,936...114,483,298
Ensembl chr 6:114,397,936...114,483,296
JBrowse link
G Hrh2 histamine receptor H2 multiple interactions ISO [[thioperamide results in increased abundance of Histamine] which results in increased activity of HRH2 protein] which results in decreased susceptibility to Scopolamine; Cimetidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH2 protein] which results in decreased susceptibility to Scopolamine] CTD PMID:11640976 PMID:19215234 NCBI chr13:54,191,970...54,236,182
Ensembl chr13:54,192,129...54,236,180
JBrowse link
G Hrh3 histamine receptor H3 multiple interactions ISO [clobenpropit binds to and results in decreased activity of HRH3 protein] which results in decreased susceptibility to Scopolamine CTD PMID:16488453 NCBI chr 2:180,099,465...180,104,484
Ensembl chr 2:180,099,465...180,104,488
JBrowse link
G Hspa2 heat shock protein 2 increases expression ISO Scopolamine results in increased expression of HSPA2 mRNA CTD PMID:12818353 NCBI chr12:76,403,812...76,406,938
Ensembl chr12:76,404,176...76,406,938
JBrowse link
G Htr1a 5-hydroxytryptamine (serotonin) receptor 1A multiple interactions ISO [4-(benzodioxan-5-yl)-1-(indan-2-yl)piperazine binds to and results in increased activity of HTR1A] which results in decreased susceptibility to Scopolamine; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [[4-(benzodioxan-5-yl)-1-(indan-2-yl)piperazine binds to and results in increased activity of HTR1A] which results in decreased susceptibility to Scopolamine] CTD PMID:10578133 NCBI chr13:105,443,693...105,448,133
Ensembl chr13:105,443,639...105,448,122
JBrowse link
G Htr2c 5-hydroxytryptamine (serotonin) receptor 2C increases expression ISO Scopolamine results in increased expression of HTR2C mRNA CTD PMID:17540011 NCBI chr  X:146,962,464...147,197,277
Ensembl chr  X:146,962,513...147,197,277
JBrowse link
G Htr6 5-hydroxytryptamine (serotonin) receptor 6 decreases expression ISO Scopolamine results in decreased expression of HTR6 mRNA CTD PMID:19733250 NCBI chr 4:139,059,706...139,075,570
Ensembl chr 4:139,061,108...139,075,570
JBrowse link
G Ifng interferon gamma multiple interactions
increases expression
ISO Fatty Acids, Unsaturated deficiency promotes the reaction [Scopolamine results in increased expression of IFNG mRNA] CTD PMID:21161262 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Il10 interleukin 10 multiple interactions
decreases expression
EXP acanthoside B inhibits the reaction [Scopolamine results in decreased expression of IL10 protein]; Tacrine inhibits the reaction [Scopolamine results in decreased expression of IL10 protein] CTD PMID:31077737 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il1a interleukin 1 alpha decreases response to substance EXP IL1A protein results in decreased susceptibility to Scopolamine CTD PMID:8003924 NCBI chr 2:129,299,609...129,310,186
Ensembl chr 2:129,299,610...129,309,972
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
EXP
ISO
Scopolamine results in increased expression of IL1B mRNA; Scopolamine results in increased expression of IL1B protein
Fatty Acids, Unsaturated deficiency promotes the reaction [Scopolamine results in increased expression of IL1B mRNA]
acanthoside B inhibits the reaction [Scopolamine results in increased expression of IL1B protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of IL1B protein]; timosaponin AIII inhibits the reaction [Scopolamine results in increased expression of IL1B protein]
CTD PMID:18357464 PMID:19426756 PMID:21161262 PMID:31077737 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions EXP IL1RN protein inhibits the reaction [CSF2 protein results in decreased susceptibility to Scopolamine] CTD PMID:8877002 NCBI chr 2:24,336,860...24,351,491
Ensembl chr 2:24,336,853...24,351,494
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO
EXP
Fatty Acids, Unsaturated deficiency promotes the reaction [Scopolamine results in increased expression of IL6 mRNA]; Scopolamine promotes the reaction [Fatty Acids, Unsaturated deficiency results in increased expression of IL6 mRNA]
acanthoside B inhibits the reaction [Scopolamine results in increased expression of IL6 protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of IL6 protein]
Scopolamine results in increased expression of IL6 mRNA; Scopolamine results in increased expression of IL6 protein
CTD PMID:18357464 PMID:21161262 PMID:31077737 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor 1 increases expression ISO Scopolamine results in increased expression of ITPR1 mRNA CTD PMID:12818353 NCBI chr 6:108,213,083...108,551,116
Ensembl chr 6:108,213,096...108,551,109
JBrowse link
G Jun jun proto-oncogene multiple interactions
decreases expression
ISO
EXP
Physostigmine inhibits the reaction [Scopolamine promotes the reaction [SK&F 82958 results in increased expression of JUN mRNA]]; Scopolamine promotes the reaction [SK&F 82958 results in increased expression of JUN mRNA]
Donepezil inhibits the reaction [Scopolamine results in decreased expression of JUN protein]; protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of JUN protein]
CTD PMID:11337201 PMID:29133030 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222
JBrowse link
G Junb jun B proto-oncogene decreases expression ISO Scopolamine results in decreased expression of JUNB mRNA CTD PMID:17540011 NCBI chr 8:84,976,909...84,978,748
Ensembl chr 8:84,974,484...84,978,718
Ensembl chr 8:84,974,484...84,978,718
JBrowse link
G Kcna4 potassium voltage-gated channel, shaker-related subfamily, member 4 increases expression ISO Scopolamine results in increased expression of KCNA4 mRNA CTD PMID:12579815 NCBI chr 2:107,290,589...107,326,804
Ensembl chr 2:107,290,639...107,298,502
JBrowse link
G Kcnb1 potassium voltage gated channel, Shab-related subfamily, member 1 increases expression ISO Scopolamine results in increased expression of KCNB1 mRNA CTD PMID:12579815 PMID:15567561 NCBI chr 2:167,095,969...167,190,072
Ensembl chr 2:167,095,969...167,190,155
JBrowse link
G Kcnd2 potassium voltage-gated channel, Shal-related family, member 2 decreases expression ISO Scopolamine results in decreased expression of KCND2 mRNA CTD PMID:12579815 NCBI chr 6:21,215,346...21,729,805
Ensembl chr 6:21,215,503...21,729,805
JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 multiple interactions ISO Scopolamine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] CTD PMID:18171729 NCBI chr 2:55,411,798...55,598,145
Ensembl chr 2:55,435,970...55,598,145
JBrowse link
G Klf2 Kruppel-like factor 2 (lung) decreases expression ISO Scopolamine results in decreased expression of KLF2 mRNA CTD PMID:17540011 NCBI chr 8:72,319,062...72,321,654
Ensembl chr 8:72,319,033...72,321,656
JBrowse link
G Klf4 Kruppel-like factor 4 (gut) decreases expression ISO Scopolamine results in decreased expression of KLF4 mRNA CTD PMID:17540011 NCBI chr 4:55,527,137...55,532,475
Ensembl chr 4:55,527,143...55,532,466
JBrowse link
G Lnpep leucyl/cystinyl aminopeptidase multiple interactions ISO [AGT protein modified form binds to and results in decreased activity of LNPEP protein] which results in decreased susceptibility to Scopolamine CTD PMID:11707427 NCBI chr17:17,527,723...17,624,489
Ensembl chr17:17,521,410...17,625,050
JBrowse link
G Madd MAP-kinase activating death domain increases expression ISO Scopolamine results in increased expression of MADD mRNA CTD PMID:12818353 NCBI chr 2:91,137,360...91,184,006
Ensembl chr 2:91,137,360...91,183,837
JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions
decreases expression
ISO Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of MAP2 protein]; withanone inhibits the reaction [Scopolamine results in decreased expression of MAP2 protein] CTD PMID:22096544 NCBI chr 1:66,175,202...66,442,583
Ensembl chr 1:66,175,273...66,442,583
JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO Scopolamine results in decreased expression of MAPT mRNA CTD PMID:12818353 NCBI chr11:104,229,409...104,332,090
Ensembl chr11:104,231,390...104,332,090
JBrowse link
G Mbp myelin basic protein multiple interactions
decreases expression
EXP Melatonin inhibits the reaction [Scopolamine results in decreased expression of MBP protein] CTD PMID:29476728 NCBI chr18:82,475,091...82,585,637
Ensembl chr18:82,475,146...82,585,637
JBrowse link
G Muc5ac mucin 5, subtypes A and C, tracheobronchial/gastric decreases expression EXP
ISO
Scopolamine results in decreased expression of MUC5AC protein CTD PMID:18357464 PMID:21161262 NCBI chr 7:141,788,958...141,819,227
Ensembl chr 7:141,788,972...141,819,231
JBrowse link
G Nefh neurofilament, heavy polypeptide decreases expression
multiple interactions
ISO Scopolamine results in decreased expression of NEFH protein
Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of NEFH protein]; withanone inhibits the reaction [Scopolamine results in decreased expression of NEFH protein]
CTD PMID:22096544 NCBI chr11:4,938,754...4,948,064
Ensembl chr11:4,938,754...4,948,064
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions
decreases expression
EXP 7-fluoro-1,3-diphenylisoquinoline-1-amine inhibits the reaction [Scopolamine results in decreased expression of NFE2L2 protein] CTD PMID:32001261 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Ngf nerve growth factor decreases response to substance
multiple interactions
increases response to substance
ISO
EXP
NGF protein results in decreased susceptibility to Scopolamine
Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NGF mRNA]
NGF protein results in increased susceptibility to Scopolamine
CTD PMID:1661212 PMID:8635431 PMID:16405025 NCBI chr 3:102,469,919...102,521,013
Ensembl chr 3:102,469,919...102,521,013
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions
increases expression
EXP acanthoside B inhibits the reaction [Scopolamine results in increased expression of NOS2 protein]; Serotonin analog inhibits the reaction [Scopolamine results in increased expression of NOS2 protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of NOS2 protein] CTD PMID:26408985 PMID:31077737 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nova1 NOVA alternative splicing regulator 1 multiple interactions ISO Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NOVA1 mRNA] CTD PMID:20470870 NCBI chr12:46,697,895...46,819,480
Ensembl chr12:46,694,517...46,818,929
JBrowse link
G Nova2 NOVA alternative splicing regulator 2 multiple interactions ISO Scopolamine inhibits the reaction [Pilocarpine results in decreased expression of NOVA2 mRNA] CTD PMID:20470870 NCBI chr 7:18,925,888...18,965,319
Ensembl chr 7:18,925,888...18,965,319
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions
decreases expression
EXP Serotonin analog inhibits the reaction [Scopolamine results in decreased expression of NQO1 protein] CTD PMID:26408985 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide quinone reductase 2 increases expression ISO Scopolamine results in increased expression of NQO2 mRNA CTD PMID:20861374 NCBI chr13:33,964,655...33,988,465
Ensembl chr13:33,964,687...33,988,443
JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 decreases expression ISO Scopolamine results in decreased expression of NR1D1 mRNA CTD PMID:17540011 NCBI chr11:98,767,932...98,775,377
Ensembl chr11:98,767,932...98,775,333
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 decreases expression ISO Scopolamine results in decreased expression of NR4A1 mRNA CTD PMID:17540011 NCBI chr15:101,253,902...101,274,795
Ensembl chr15:101,254,269...101,274,795
JBrowse link
G Ntf3 neurotrophin 3 multiple interactions ISO Scopolamine inhibits the reaction [Pilocarpine results in decreased expression of NTF3 mRNA] CTD PMID:8635431 NCBI chr 6:126,101,412...126,166,772
Ensembl chr 6:126,101,412...126,166,910
JBrowse link
G Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 multiple interactions
decreases expression
ISO
EXP
Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NTRK2 mRNA]
Scopolamine results in decreased expression of NTRK2 protein
[acanthoside B co-treated with Scopolamine] results in increased phosphorylation of NTRK2 protein; [Tacrine co-treated with Scopolamine] results in increased phosphorylation of NTRK2 protein; Melatonin inhibits the reaction [Scopolamine results in decreased expression of NTRK2 protein]
CTD PMID:8635431 PMID:29476728 PMID:31077737 NCBI chr13:58,806,472...59,133,970
Ensembl chr13:58,806,569...59,133,970
JBrowse link
G Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 multiple interactions ISO Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NTRK3 mRNA] CTD PMID:8635431 NCBI chr 7:78,179,986...78,581,034
Ensembl chr 7:78,175,959...78,738,012
JBrowse link
G Pdcd4 programmed cell death 4 increases expression ISO Scopolamine results in increased expression of PDCD4 mRNA CTD PMID:12818353 NCBI chr19:53,892,231...53,937,592
Ensembl chr19:53,892,231...53,929,860
JBrowse link
G Pdyn prodynorphin decreases response to substance
multiple interactions
increases expression
EXP
ISO
PDYN protein modified form results in decreased susceptibility to Scopolamine
MR 2266 inhibits the reaction [PDYN protein modified form results in decreased susceptibility to Scopolamine]
Scopolamine results in increased expression of PDYN mRNA
CTD PMID:7768285 PMID:17540011 NCBI chr 2:129,686,549...129,699,938
Ensembl chr 2:129,686,565...129,699,844
JBrowse link
G Penk preproenkephalin multiple interactions ISO Scopolamine inhibits the reaction [Haloperidol results in increased expression of PENK mRNA] CTD PMID:7637876 NCBI chr 4:4,133,536...4,138,815
Ensembl chr 4:4,133,531...4,138,819
JBrowse link
G Pgam1 phosphoglycerate mutase 1 decreases expression ISO Scopolamine results in decreased expression of PGAM1 mRNA CTD PMID:12818353 NCBI chr19:41,911,871...41,918,665
Ensembl chr19:41,911,923...41,918,660
JBrowse link
G Prep prolyl endopeptidase increases response to substance
increases expression
multiple interactions
ISO PREP protein results in increased susceptibility to Scopolamine
Scopolamine results in increased expression of PREP protein
Piracetam inhibits the reaction [Scopolamine results in increased expression of PREP protein]
CTD PMID:17244263 PMID:18318186 NCBI chr10:45,067,216...45,162,751
Ensembl chr10:45,067,203...45,167,198
JBrowse link
G Prkra protein kinase, interferon inducible double stranded RNA dependent activator decreases expression ISO Scopolamine results in decreased expression of PRKRA mRNA CTD PMID:12818353 NCBI chr 2:76,609,215...76,648,220
Ensembl chr 2:76,629,898...76,648,015
JBrowse link
G Psen2 presenilin 2 decreases expression ISO Scopolamine results in decreased expression of PSEN2 mRNA CTD PMID:12818353 NCBI chr 1:180,227,004...180,263,467
Ensembl chr 1:180,227,004...180,263,438
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
EXP Scopolamine results in increased expression of PTGS2 protein
acanthoside B inhibits the reaction [Scopolamine results in increased expression of PTGS2 protein]; Serotonin analog inhibits the reaction [Scopolamine results in increased expression of PTGS2 protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of PTGS2 protein]
CTD PMID:26408985 PMID:31077737 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Rab14 RAB14, member RAS oncogene family increases expression ISO Scopolamine results in increased expression of RAB14 mRNA CTD PMID:17540011 NCBI chr 2:35,180,205...35,201,120
Ensembl chr 2:35,180,205...35,201,120
JBrowse link
G Rapgef3 Rap guanine nucleotide exchange factor (GEF) 3 decreases expression ISO Scopolamine results in decreased expression of RAPGEF3 mRNA CTD PMID:12818353 NCBI chr15:97,744,770...97,768,419
Ensembl chr15:97,744,770...97,767,972
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP mangiferin inhibits the reaction [Scopolamine results in increased phosphorylation of and results in increased activity of RELA protein]; Scopolamine results in increased phosphorylation of and results in increased activity of RELA protein; timosaponin AIII inhibits the reaction [Scopolamine results in increased phosphorylation of and results in increased activity of RELA protein] CTD PMID:19182383 PMID:19426756 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Rem2 rad and gem related GTP binding protein 2 decreases expression ISO Scopolamine results in decreased expression of REM2 mRNA CTD PMID:17540011 NCBI chr14:54,476,100...54,480,434
Ensembl chr14:54,476,100...54,480,431
JBrowse link
G Rgs7bp regulator of G-protein signalling 7 binding protein decreases expression ISO Scopolamine results in decreased expression of RGS7BP mRNA CTD PMID:17540011 NCBI chr13:104,945,904...105,054,930
Ensembl chr13:104,945,904...105,054,930
JBrowse link
G Robo3 roundabout guidance receptor 3 decreases expression ISO Scopolamine results in decreased expression of ROBO3 mRNA CTD PMID:17540011 NCBI chr 9:37,416,045...37,433,436
Ensembl chr 9:37,415,669...37,433,246
JBrowse link
G Rraga Ras-related GTP binding A increases expression ISO Scopolamine results in increased expression of RRAGA mRNA CTD PMID:12818353 NCBI chr 4:86,575,673...86,577,285
Ensembl chr 4:86,575,668...86,577,285
JBrowse link
G S100a4 S100 calcium binding protein A4 decreases expression ISO Scopolamine results in decreased expression of S100A4 mRNA CTD PMID:17540011 NCBI chr 3:90,603,770...90,606,045
Ensembl chr 3:90,603,771...90,606,045
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 increases expression ISO Scopolamine results in increased expression of S1PR1 mRNA CTD PMID:12818353 NCBI chr 3:115,710,433...115,715,055
Ensembl chr 3:115,710,433...115,715,072
JBrowse link
G Scamp2 secretory carrier membrane protein 2 increases expression ISO Scopolamine results in increased expression of SCAMP2 mRNA CTD PMID:12818353 NCBI chr 9:57,560,944...57,588,798
Ensembl chr 9:57,560,943...57,588,795
JBrowse link
G Sigmar1 sigma non-opioid intracellular receptor 1 multiple interactions EXP [2-(4-morpholino)ethyl-1-phenylcyclohexane-1-carboxylate binds to and results in increased activity of SIGMAR1 protein] which results in decreased susceptibility to Scopolamine; [igmesine binds to and results in increased activity of SIGMAR1 protein] which results in decreased susceptibility to Scopolamine CTD PMID:12028363 NCBI chr 4:41,738,493...41,741,359
Ensembl chr 4:41,738,493...41,756,157
JBrowse link
G Slc47a1 solute carrier family 47, member 1 multiple interactions ISO Scopolamine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr11:61,343,400...61,378,842
Ensembl chr11:61,343,401...61,378,345
JBrowse link
G Slc47a2 solute carrier family 47, member 2 multiple interactions ISO Scopolamine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr11:61,301,627...61,342,860
Ensembl chr11:61,301,631...61,342,860
JBrowse link
G Sult1a1 sulfotransferase family 1A, phenol-preferring, member 1 increases expression ISO Scopolamine results in increased expression of SULT1A1 mRNA CTD PMID:17540011 NCBI chr 7:126,672,865...126,690,443
Ensembl chr 7:126,672,865...126,676,432
JBrowse link
G Syp synaptophysin multiple interactions
increases expression
ISO cyclo-L-glycyl-L-2-allylproline inhibits the reaction [Scopolamine results in increased expression of SYP protein] CTD PMID:20188767 NCBI chr  X:7,638,580...7,653,256
Ensembl chr  X:7,638,471...7,653,256
JBrowse link
G Tac1 tachykinin 1 decreases response to substance ISO TAC1 protein modified form results in decreased susceptibility to Scopolamine CTD PMID:20600432 NCBI chr 6:7,555,061...7,562,978
Ensembl chr 6:7,554,879...7,565,834
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP
ISO
acanthoside B inhibits the reaction [Scopolamine results in increased expression of TNF protein]; mangiferin inhibits the reaction [Scopolamine results in increased expression of TNF protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of TNF protein]; timosaponin AIII inhibits the reaction [Scopolamine results in increased expression of TNF protein]
Scopolamine results in increased expression of TNF mRNA
Scopolamine results in increased expression of TNF mRNA; Scopolamine results in increased expression of TNF protein
CTD PMID:18357464 PMID:19182383 PMID:19426756 PMID:21161262 PMID:31077737 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tnrc6a trinucleotide repeat containing 6a decreases expression ISO Scopolamine results in decreased expression of TNRC6A mRNA CTD PMID:17540011 NCBI chr 7:123,031,101...123,195,296
Ensembl chr 7:123,123,885...123,195,296
JBrowse link
G Tpd52l1 tumor protein D52-like 1 increases expression ISO Scopolamine results in increased expression of TPD52L1 mRNA CTD PMID:17540011 NCBI chr10:31,332,373...31,445,987
Ensembl chr10:31,332,376...31,445,958
JBrowse link
G Vgf VGF nerve growth factor inducible decreases expression ISO Scopolamine results in decreased expression of VGF mRNA CTD PMID:17540011 NCBI chr 5:137,025,301...137,033,351
Ensembl chr 5:137,026,392...137,033,351
JBrowse link
G Vip vasoactive intestinal polypeptide decreases response to substance ISO VIP protein results in decreased susceptibility to Scopolamine CTD PMID:8208360 NCBI chr10:5,639,193...5,647,617
Ensembl chr10:5,639,218...5,647,617
JBrowse link
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 multiple interactions
decreases activity
ISO Atropine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Atropine results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 2:69,238,282...69,342,616
Ensembl chr 2:69,238,282...69,342,616
JBrowse link
G Abl1 c-abl oncogene 1, non-receptor tyrosine kinase multiple interactions ISO [Parathion co-treated with Atropine] results in increased expression of ABL1 mRNA CTD PMID:17390078 NCBI chr 2:31,688,244...31,807,093
Ensembl chr 2:31,688,376...31,804,227
JBrowse link
G Ache acetylcholinesterase multiple interactions ISO
EXP
Atropine inhibits the reaction [[Organophosphorus Compounds results in decreased activity of ACHE protein] which results in increased abundance of Acetylcholine]; Atropine inhibits the reaction [Carbachol results in increased metabolism of and results in increased secretion of ACHE protein]; Atropine inhibits the reaction [Paraoxon results in increased expression of ACHE protein]
[Atropine co-treated with Obidoxime Chloride] inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of ACHE protein; [Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein; [pralidoxime co-treated with Atropine] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; [tariquidar co-treated with asoxime chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; Atropine inhibits the reaction [Methyl Parathion results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [[Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [[Atropine co-treated with Curcumin] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]]
[1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [[1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide co-treated with cucurbit(7)uril] co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; Atropine inhibits the reaction [Sarin results in decreased activity of ACHE protein]; Atropine promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; Atropine promotes the reaction [haloxon results in increased phosphorylation of ACHE protein]; Atropine promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein]
CTD PMID:2241428 PMID:10421444 PMID:17963125 PMID:20105433 PMID:21600273 PMID:21787676 PMID:22783142 PMID:23047022 PMID:24881594 PMID:26751814 PMID:31794810 NCBI chr 5:137,288,247...137,294,466
Ensembl chr 5:137,287,519...137,294,466
JBrowse link
G Adcy5 adenylate cyclase 5 increases response to substance EXP ADCY5 protein results in increased susceptibility to Atropine CTD PMID:12869393 NCBI chr16:35,154,494...35,305,743
Ensembl chr16:35,154,877...35,305,738
JBrowse link
G Aqp5 aquaporin 5 multiple interactions EXP Atropine inhibits the reaction [Pilocarpine affects the localization of AQP5 protein] CTD PMID:26208470 NCBI chr15:99,591,028...99,594,829
Ensembl chr15:99,590,782...99,594,829
JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the expression of BAX mRNA] CTD PMID:21971501 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcar1 breast cancer anti-estrogen resistance 1 multiple interactions ISO Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]] CTD PMID:10537051 NCBI chr 8:111,710,474...111,743,849
Ensembl chr 8:111,710,474...111,743,809
JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO [Atropine co-treated with pralidoxime] results in decreased expression of BCHE protein; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of BCHE protein
[BCHE protein co-treated with asoxime chloride co-treated with pro-diazepam co-treated with Atropine] results in decreased susceptibility to VX
CTD PMID:17963125 PMID:22981459 NCBI chr 3:73,635,805...73,708,436
Ensembl chr 3:73,635,808...73,708,415
JBrowse link
G Bdkrb2 bradykinin receptor, beta 2 multiple interactions EXP BDKRB2 affects the susceptibility to [Propranolol co-treated with Atropine] CTD PMID:10614985 NCBI chr12:105,563,172...105,595,244
Ensembl chr12:105,563,226...105,595,237
JBrowse link
G Bmp6 bone morphogenetic protein 6 multiple interactions ISO Atropine inhibits the reaction [Carbon Tetrachloride results in increased expression of BMP6 mRNA] CTD PMID:18472332 NCBI chr13:38,345,716...38,500,314
Ensembl chr13:38,345,107...38,500,302
JBrowse link
G Cacna1e calcium channel, voltage-dependent, R type, alpha 1E subunit multiple interactions ISO Atropine inhibits the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]] CTD PMID:12663092 NCBI chr 1:154,390,806...154,884,785
Ensembl chr 1:154,390,731...154,884,501
JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha affects activity ISO Atropine affects the activity of CALCA protein CTD PMID:7906887 PMID:10075105 NCBI chr 7:114,625,981...114,636,910
Ensembl chr 7:114,631,478...114,636,357
JBrowse link
G Casp3 caspase 3 increases expression ISO Atropine results in increased expression of CASP3 mRNA CTD PMID:19815060 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Ccl5 chemokine (C-C motif) ligand 5 multiple interactions EXP [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 protein] CTD PMID:22245128 NCBI chr11:83,525,778...83,530,518
Ensembl chr11:83,525,778...83,530,518
JBrowse link
G Ccna1 cyclin A1 multiple interactions
increases expression
ISO [Parathion co-treated with Atropine] results in increased expression of CCNA1 mRNA
Atropine results in increased expression of CCNA1 mRNA
CTD PMID:17390078 NCBI chr 3:55,045,469...55,057,634
Ensembl chr 3:55,045,469...55,055,501
JBrowse link
G Ccnd3 cyclin D3 multiple interactions ISO [Parathion co-treated with Atropine] results in increased expression of CCND3 mRNA CTD PMID:17390078 NCBI chr17:47,505,051...47,599,689
Ensembl chr17:47,505,051...47,599,691
JBrowse link
G Ccne1 cyclin E1 multiple interactions
increases expression
ISO [Parathion co-treated with Atropine] results in increased expression of CCNE1 mRNA
Atropine results in increased expression of CCNE1 mRNA
CTD PMID:17390078 NCBI chr 7:38,097,984...38,107,490
Ensembl chr 7:38,097,984...38,107,534
JBrowse link
G Ccne2 cyclin E2 increases expression
multiple interactions
ISO Atropine results in increased expression of CCNE2 mRNA
[Parathion co-treated with Atropine] results in increased expression of CCNE2 mRNA
CTD PMID:17390078 NCBI chr 4:11,190,433...11,204,779
Ensembl chr 4:11,191,351...11,204,779
JBrowse link
G Cd40 CD40 antigen multiple interactions ISO Atropine inhibits the reaction [Carbachol results in increased expression of CD40 protein] CTD PMID:16879495 NCBI chr 2:165,055,614...165,071,654
Ensembl chr 2:165,055,627...165,072,948
JBrowse link
G Cdc20 cell division cycle 20 increases expression
multiple interactions
ISO Atropine results in increased expression of CDC20 mRNA
[Parathion co-treated with Atropine] results in increased expression of CDC20 mRNA
CTD PMID:17390078 NCBI chr 4:118,432,901...118,437,343
Ensembl chr 4:118,432,901...118,437,352
JBrowse link
G Cdc6 cell division cycle 6 multiple interactions ISO [Parathion co-treated with Atropine] results in increased expression of CDC6 mRNA CTD PMID:17390078 NCBI chr11:98,907,709...98,923,942
Ensembl chr11:98,907,801...98,923,940
JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression
multiple interactions
ISO Atropine results in increased expression of CDK1 mRNA
[Parathion co-treated with Atropine] results in increased expression of CDK1 mRNA
CTD PMID:17390078 NCBI chr10:69,335,146...69,352,912
Ensembl chr10:69,335,146...69,352,938
JBrowse link
G Ces1d carboxylesterase 1D multiple interactions ISO Atropine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate] CTD PMID:9311626 NCBI chr 8:93,166,072...93,197,804
Ensembl chr 8:93,166,068...93,197,838
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1, CNS multiple interactions
decreases activity
EXP
ISO
Atropine binds to and results in decreased activity of CHRM1 protein; Atropine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]
Atropine results in decreased activity of CHRM1 protein
Atropine affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]
CTD PMID:16439611 PMID:18316702 PMID:31830555 NCBI chr19:8,664,005...8,683,606
Ensembl chr19:8,663,789...8,683,587
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2, cardiac multiple interactions ISO Atropine binds to and results in decreased activity of CHRM2 protein CTD PMID:15140916 NCBI chr 6:36,387,991...36,528,638
Ensembl chr 6:36,388,084...36,528,414
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3, cardiac multiple interactions
decreases activity
ISO Atropine binds to and results in decreased activity of CHRM3 protein; Atropine inhibits the reaction [Carbachol results in increased activity of CHRM3 protein]
Atropine results in decreased activity of CHRM3 protein
CTD PMID:15140916 PMID:20708676 PMID:31830555 NCBI chr13:9,875,486...10,361,062
Ensembl chr13:9,875,486...10,360,847
JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 affects binding
multiple interactions
ISO Atropine binds to CHRM4 protein
[WIN 62577 co-treated with Quinuclidinyl Benzilate] inhibits the reaction [Atropine binds to CHRM4 protein]
CTD PMID:16709648 NCBI chr 2:91,922,189...91,929,835
Ensembl chr 2:91,927,249...91,928,688
JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 multiple interactions ISO Atropine inhibits the reaction [Acetylcholine results in increased activity of CHRM5 protein] CTD PMID:31323226 NCBI chr 2:112,478,733...112,536,361
Ensembl chr 2:112,479,171...112,480,769
JBrowse link
G Chrna4 cholinergic receptor, nicotinic, alpha polypeptide 4 multiple interactions
affects binding
ISO Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
Atropine binds to [CHRNA4 protein binds to CHRNB2 protein]
Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 protein]]
CTD PMID:15733544 PMID:21791372 NCBI chr 2:181,022,311...181,043,579
Ensembl chr 2:181,018,380...181,043,546
JBrowse link
G Chrnb2 cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) affects binding
multiple interactions
ISO Atropine binds to [CHRNA4 protein binds to CHRNB2 protein]
Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 protein]]
Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
CTD PMID:15733544 PMID:21791372 NCBI chr 3:89,753,448...89,764,632
Ensembl chr 3:89,746,195...89,764,632
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of CREB1 protein] CTD PMID:21971501 NCBI chr 1:64,532,794...64,604,548
Ensembl chr 1:64,532,645...64,604,548
JBrowse link
G Crh corticotropin releasing hormone multiple interactions ISO [Atropine co-treated with SR 140333 co-treated with SR 48968] results in decreased activity of CRH protein
Atropine inhibits the reaction [acephate results in increased expression of CRH mRNA]; Atropine inhibits the reaction [acephate results in increased secretion of CRH protein]; Atropine inhibits the reaction [methamidophos results in increased expression of CRH mRNA]; Atropine inhibits the reaction [methamidophos results in increased secretion of CRH protein]
CTD PMID:12039681 PMID:12906840 NCBI chr 3:19,693,401...19,695,396
Ensembl chr 3:19,693,401...19,695,396
JBrowse link
G Ctnnb1 catenin (cadherin associated protein), beta 1 multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of CTNNB1 protein mutant form]; Atropine inhibits the reaction [Parathion results in increased expression of CTNNB1 protein] CTD PMID:17390078 NCBI chr 9:120,933,400...120,960,507
Ensembl chr 9:120,929,216...120,960,507
JBrowse link
G Cxcl3 chemokine (C-X-C motif) ligand 3 multiple interactions EXP [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 protein] CTD PMID:22245128 NCBI chr 5:90,786,101...90,788,093
Ensembl chr 5:90,786,103...90,789,600
JBrowse link
G Dvl2 dishevelled segment polarity protein 2 multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of DVL2 protein] CTD PMID:17390078 NCBI chr11:70,000,592...70,010,109
Ensembl chr11:70,000,595...70,012,301
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO EDN1 protein results in decreased activity of [Atropine co-treated with Histamine] CTD PMID:12906840 NCBI chr13:42,301,476...42,307,990
Ensembl chr13:42,301,476...42,307,990
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of EGFR protein] CTD PMID:17390078 NCBI chr11:16,752,203...16,913,907
Ensembl chr11:16,752,203...16,918,158
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR1 mRNA] CTD PMID:7968354 NCBI chr18:34,861,207...34,864,956
Ensembl chr18:34,859,823...34,864,984
JBrowse link
G Egr2 early growth response 2 multiple interactions ISO Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA] CTD PMID:7968354 NCBI chr10:67,534,469...67,542,188
Ensembl chr10:67,535,475...67,542,188
JBrowse link
G Ezr ezrin multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of EZR protein] CTD PMID:17390078 NCBI chr17:6,738,131...6,782,780
Ensembl chr17:6,738,041...6,782,784
JBrowse link
G F2 coagulation factor II multiple interactions EXP [Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in decreased expression of F2 mRNA; [Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in increased activity of F2 protein CTD PMID:30515700 NCBI chr 2:91,612,397...91,636,457
Ensembl chr 2:91,625,320...91,636,414
JBrowse link
G F2r coagulation factor II (thrombin) receptor multiple interactions EXP [Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in increased expression of F2R protein CTD PMID:30515700 NCBI chr13:95,601,780...95,618,466
Ensembl chr13:95,601,803...95,618,487
JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions
increases expression
ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased expression of FOS protein]; Atropine inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]
Atropine inhibits the reaction [Paraoxon results in increased expression of FOS mRNA]
Atropine results in increased expression of FOS protein
CTD PMID:7968354 PMID:8281324 PMID:21787676 PMID:21971501 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Ghrl ghrelin multiple interactions ISO Atropine inhibits the reaction [[Pentobarbital co-treated with L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide] results in increased expression of GHRL protein] CTD PMID:16959836 NCBI chr 6:113,716,119...113,719,911
Ensembl chr 6:113,716,119...113,719,880
JBrowse link
G Glra1 glycine receptor, alpha 1 subunit multiple interactions ISO Atropine binds to and results in decreased activity of GLRA1 protein CTD PMID:15081878 NCBI chr11:55,514,239...55,608,198
Ensembl chr11:55,514,238...55,608,198
JBrowse link
G Grm4 glutamate receptor, metabotropic 4 multiple interactions ISO Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] CTD PMID:18171729 NCBI chr17:27,422,387...27,513,826
Ensembl chr17:27,422,387...27,521,403
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of ICAM1 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of ICAM1 protein] CTD PMID:22245128 NCBI chr 9:21,015,940...21,028,814
Ensembl chr 9:21,015,985...21,028,817
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of IL1B mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of IL1B protein] CTD PMID:22245128 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 mRNA]; [Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 protein] CTD PMID:22245128 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Jun jun proto-oncogene multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of JUN protein] CTD PMID:21971501 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222
JBrowse link
G Junb jun B proto-oncogene multiple interactions ISO Atropine inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA] CTD PMID:7968354 NCBI chr 8:84,976,909...84,978,748
Ensembl chr 8:84,974,484...84,978,718
Ensembl chr 8:84,974,484...84,978,718
JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 multiple interactions ISO Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] CTD PMID:18171729 NCBI chr 2:55,411,798...55,598,145
Ensembl chr 2:55,435,970...55,598,145
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of KIT protein] CTD PMID:17390078 NCBI chr 5:75,574,987...75,656,722
Ensembl chr 5:75,574,916...75,656,722
JBrowse link
G Ltf lactotransferrin multiple interactions ISO Atropine inhibits the reaction [methylcholine results in increased secretion of LTF protein] CTD PMID:11112886 NCBI chr 9:111,019,292...111,042,766
Ensembl chr 9:111,019,271...111,042,767
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK1 protein] CTD PMID:21971501 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk14 mitogen-activated protein kinase 14 multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK14 protein] CTD PMID:21971501 NCBI chr17:28,691,342...28,748,405
Ensembl chr17:28,691,329...28,748,406
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK3 protein] CTD PMID:21971501 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK8 protein] CTD PMID:21971501 NCBI chr14:33,377,898...33,447,353
Ensembl chr14:33,377,898...33,447,158
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 multiple interactions
increases expression
ISO [Parathion co-treated with Atropine] results in increased expression of MCM4 mRNA
Atropine results in increased expression of MCM4 mRNA
CTD PMID:17390078 NCBI chr16:15,623,897...15,637,400
Ensembl chr16:15,623,897...15,637,400
JBrowse link
G Mcm6 minichromosome maintenance complex component 6 increases expression
multiple interactions
ISO Atropine results in increased expression of MCM6 mRNA
[Parathion co-treated with Atropine] results in increased expression of MCM6 mRNA
CTD PMID:17390078 NCBI chr 1:128,331,575...128,359,705
Ensembl chr 1:128,331,590...128,359,664
JBrowse link
G Nefh neurofilament, heavy polypeptide affects expression ISO Atropine affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr11:4,938,754...4,948,064
Ensembl chr11:4,938,754...4,948,064
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 increases expression ISO Atropine results in increased expression of NLRP3 mRNA CTD PMID:28138970 NCBI chr11:59,541,569...59,566,955
Ensembl chr11:59,541,568...59,566,956
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO Atropine inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; Atropine inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA] CTD PMID:15610444 PMID:16944022 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Notch4 notch 4 multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of NOTCH4 protein] CTD PMID:17390078 NCBI chr17:34,564,286...34,588,543
Ensembl chr17:34,564,268...34,588,503
JBrowse link
G Nppa natriuretic peptide type A affects activity ISO Atropine affects the activity of NPPA protein modified form CTD PMID:1363893 NCBI chr 4:148,000,722...148,002,074
Ensembl chr 4:148,000,722...148,002,079
JBrowse link
G Oprl1 opioid receptor-like 1 multiple interactions ISO Atropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein] CTD PMID:12007927 NCBI chr 2:181,715,000...181,720,985
Ensembl chr 2:181,715,016...181,720,985
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Atropine inhibits the reaction [Malathion results in increased expression of PCNA]; Atropine inhibits the reaction [Parathion results in increased expression of PCNA] CTD PMID:12762645 NCBI chr 2:132,249,286...132,253,180
Ensembl chr 2:132,249,162...132,253,314
JBrowse link
G Pnoc prepronociceptin multiple interactions ISO Atropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein] CTD PMID:12007927 NCBI chr14:65,400,673...65,425,564
Ensembl chr14:65,400,673...65,425,472
JBrowse link
G Pomc pro-opiomelanocortin-alpha multiple interactions ISO Atropine inhibits the reaction [Acetylcholine results in increased expression of POMC protein] CTD PMID:7588217 NCBI chr12:3,954,945...3,960,643
Ensembl chr12:3,954,951...3,960,642
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP [Atropine co-treated with Glucose] binds to PPARA protein; Atropine inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]] CTD PMID:18812576 NCBI chr15:85,734,910...85,806,851
Ensembl chr15:85,734,983...85,802,819
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Atropine affects the reaction [Indomethacin results in increased expression of PTGS2]; Atropine inhibits the reaction [Indomethacin results in increased expression of PTGS2 mRNA]; Atropine inhibits the reaction [Indomethacin results in increased expression of PTGS2]; Atropine inhibits the reaction [SC 560 results in increased expression of PTGS2 mRNA] CTD PMID:15104355 PMID:15610444 PMID:16259740 PMID:16804302 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Ptk2 PTK2 protein tyrosine kinase 2 multiple interactions ISO Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein]] CTD PMID:10537051 NCBI chr15:73,205,102...73,423,820
Ensembl chr15:73,205,102...73,423,280
JBrowse link
G Pxn paxillin multiple interactions ISO Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]] CTD PMID:10537051 NCBI chr 5:115,491,970...115,555,987
Ensembl chr 5:115,506,676...115,555,987
JBrowse link
G Rac3 Rac family small GTPase 3 multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of RAC3 protein] CTD PMID:17390078 NCBI chr11:120,721,468...120,723,969
Ensembl chr11:120,721,470...120,723,969
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of RELA protein] CTD PMID:21971501 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of RHOA protein] CTD PMID:17390078 NCBI chr 9:108,306,160...108,337,943
Ensembl chr 9:108,306,129...108,337,934
JBrowse link
G Slc22a1 solute carrier family 22 (organic cation transporter), member 1 multiple interactions ISO Atropine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Atropine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:16263091 PMID:21641380 NCBI chr17:12,648,874...12,675,838
Ensembl chr17:12,648,869...12,675,829
JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO Atropine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Atropine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Atropine inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium] CTD PMID:16263091 PMID:21599003 PMID:23770354 NCBI chr17:12,584,189...12,628,489
Ensembl chr17:12,584,132...12,628,488
JBrowse link
G Slc22a3 solute carrier family 22 (organic cation transporter), member 3 multiple interactions
increases uptake
ISO Atropine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]
SLC22A3 protein results in increased uptake of Atropine
CTD PMID:16263091 NCBI chr17:12,419,972...12,507,704
Ensembl chr17:12,418,960...12,507,704
JBrowse link
G Slc22a4 solute carrier family 22 (organic cation transporter), member 4 multiple interactions ISO Atropine inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium] CTD PMID:21641380 NCBI chr11:53,983,115...54,030,040
Ensembl chr11:53,983,123...54,028,090
JBrowse link
G Slc47a1 solute carrier family 47, member 1 multiple interactions ISO Atropine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr11:61,343,400...61,378,842
Ensembl chr11:61,343,401...61,378,345
JBrowse link
G Slc47a2 solute carrier family 47, member 2 multiple interactions ISO Atropine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr11:61,301,627...61,342,860
Ensembl chr11:61,301,631...61,342,860
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Atropine results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 2:164,354,070...164,356,507
Ensembl chr 2:164,354,070...164,389,095
JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions EXP [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of SOCS3 mRNA] CTD PMID:22245128 NCBI chr11:117,966,079...117,970,336
Ensembl chr11:117,966,079...117,970,047
JBrowse link
G Spn sialophorin increases response to substance EXP SPN protein results in increased susceptibility to Atropine CTD PMID:18711009 NCBI chr 7:127,123,637...127,145,552
Ensembl chr 7:127,132,232...127,137,823
JBrowse link
G Tat tyrosine aminotransferase multiple interactions ISO [Atropine co-treated with Obidoxime Chloride co-treated with Diazepam] inhibits the reaction [Dichlorvos results in increased expression of TAT protein] CTD PMID:7761789 NCBI chr 8:109,986,078...109,999,804
Ensembl chr 8:109,990,437...109,999,803
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Atropine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA] CTD PMID:18472332 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of TNF mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of TNF protein] CTD PMID:22245128 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Trio triple functional domain (PTPRF interacting) multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of TRIO protein] CTD PMID:17390078 NCBI chr15:27,730,649...28,025,848
Ensembl chr15:27,730,651...28,025,848
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO Atropine inhibits the reaction [Malathion results in increased expression of TP53 protein]; Atropine inhibits the reaction [Parathion results in increased expression of TP53 protein] CTD PMID:12762645 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 decreases response to substance EXP TRPA1 gene mutant form results in decreased susceptibility to Atropine CTD PMID:29627347 NCBI chr 1:14,872,644...14,918,862
Ensembl chr 1:14,872,648...14,918,862
JBrowse link
G Tshb thyroid stimulating hormone, beta subunit multiple interactions ISO [pralidoxime co-treated with Atropine] inhibits the reaction [methamidophos results in decreased expression of TSHB protein] CTD PMID:15891268 NCBI chr 3:102,777,398...102,789,082
Ensembl chr 3:102,775,465...102,782,718
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of VCAM1 mRNA] CTD PMID:22245128 NCBI chr 3:116,110,020...116,129,688
Ensembl chr 3:116,109,949...116,129,688
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21727
    chemical entity 21725
      molecular entity 21712
        polyatomic entity 21602
          heteroatomic molecular entity 21534
            hydroxides 20148
              organic hydroxy compound 19171
                hydroxy carboxylic acid 3736
                  hydroxy monocarboxylic acid 3736
                    3-hydroxy monocarboxylic acid 223
                      (1-hydroxycyclohexyl)acetic acid + 0
                      (2S,3R)-3-hydroxy-2-methylpentanoic acid 0
                      (3R)-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylic acid 0
                      (3S,4S)-3-hydroxy-4-methyldecanoic acid + 0
                      (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoic acid 0
                      (S)-3-hydroxy-2-oxo-3-phenylpropanoic acid 0
                      (S)-3-hydroxydecanoic acid + 0
                      (S)-3-hydroxytetradecanoic acid + 0
                      2-(hydroxymethyl)-4-oxobutanoic acid 0
                      2-ethyl-3-hydroxybutyric acid 0
                      3-hydroxy fatty acid + 0
                      3-hydroxy-2,2-dimethylbutyric acid 0
                      3-hydroxy-2-methylbutanoic acid + 0
                      3-hydroxy-3-methyl-2-oxopentanoic acid + 0
                      3-hydroxy-3-methylhexanoic acid + 0
                      3-hydroxy-5-oxohexanoic acid + 0
                      3-hydroxybut-2-enoic acid + 4
                      3-hydroxybutyric acid + 25
                      3-hydroxydocosanoic acid + 0
                      3-hydroxyhexacosanoic acid + 0
                      3-hydroxyhexanoic acid + 0
                      3-hydroxyisobutyric acid + 0
                      3-hydroxyisovaleric acid + 5
                      3-hydroxyoctadecanoic acid + 0
                      3-hydroxyoctanoic acid + 0
                      3-hydroxypropionic acid + 1
                      3-hydroxypyruvic acid 2
                      3-hydroxytetradecanoic acid + 0
                      agrochelin 0
                      gamma-amino-beta-hydroxybutyric acid + 0
                      mevaldic acid 0
                      mutalomycin 0
                      peramivir 0
                      tropic acid + 195
Path 2
Term Annotations click to browse term
  CHEBI ontology 21727
    subatomic particle 21713
      composite particle 21713
        hadron 21713
          baryon 21713
            nucleon 21713
              atomic nucleus 21713
                atom 21713
                  main group element atom 21630
                    p-block element atom 21630
                      carbon group element atom 21435
                        carbon atom 21332
                          organic molecular entity 21332
                            organic group 19890
                              organic divalent group 19880
                                organodiyl group 19880
                                  carbonyl group 19863
                                    carbonyl compound 19863
                                      carboxylic acid 19153
                                        hydroxy carboxylic acid 3736
                                          hydroxy monocarboxylic acid 3736
                                            3-hydroxy monocarboxylic acid 223
                                              (1-hydroxycyclohexyl)acetic acid + 0
                                              (2S,3R)-3-hydroxy-2-methylpentanoic acid 0
                                              (3R)-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylic acid 0
                                              (3S,4S)-3-hydroxy-4-methyldecanoic acid + 0
                                              (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoic acid 0
                                              (S)-3-hydroxy-2-oxo-3-phenylpropanoic acid 0
                                              (S)-3-hydroxydecanoic acid + 0
                                              (S)-3-hydroxytetradecanoic acid + 0
                                              2-(hydroxymethyl)-4-oxobutanoic acid 0
                                              2-ethyl-3-hydroxybutyric acid 0
                                              3-hydroxy fatty acid + 0
                                              3-hydroxy-2,2-dimethylbutyric acid 0
                                              3-hydroxy-2-methylbutanoic acid + 0
                                              3-hydroxy-3-methyl-2-oxopentanoic acid + 0
                                              3-hydroxy-3-methylhexanoic acid + 0
                                              3-hydroxy-5-oxohexanoic acid + 0
                                              3-hydroxybut-2-enoic acid + 4
                                              3-hydroxybutyric acid + 25
                                              3-hydroxydocosanoic acid + 0
                                              3-hydroxyhexacosanoic acid + 0
                                              3-hydroxyhexanoic acid + 0
                                              3-hydroxyisobutyric acid + 0
                                              3-hydroxyisovaleric acid + 5
                                              3-hydroxyoctadecanoic acid + 0
                                              3-hydroxyoctanoic acid + 0
                                              3-hydroxypropionic acid + 1
                                              3-hydroxypyruvic acid 2
                                              3-hydroxytetradecanoic acid + 0
                                              agrochelin 0
                                              gamma-amino-beta-hydroxybutyric acid + 0
                                              mevaldic acid 0
                                              mutalomycin 0
                                              peramivir 0
                                              tropic acid + 195
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