Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3-hydroxy monocarboxylic acid
go back to main search page
Accession:CHEBI:35969 term browser browse the term
Definition:A hydroxy monocarboxylic acid that has a hydroxy group beta to the carboxy group.
Synonyms:related_synonym: 3-hydroxy acid;   3-hydroxy monocarboxylic acids;   beta-hydroxy acid;   beta-hydroxy acids;   beta-hydroxy carboxylic acid;   beta-hydroxy carboxylic acids


show annotations for term's descendants           Sort by:
 
(S)-atropine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP Hyoscyamine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638
JBrowse link
3-hydroxybutyric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AQP9 aquaporin 9 increases uptake ISO AQP9 protein results in increased uptake of 3-Hydroxybutyric Acid CTD PMID:9733774 NCBI chr15:58,138,169...58,185,911
Ensembl chr15:58,138,169...58,185,911
JBrowse link
G ATG5 autophagy related 5 increases abundance EXP ATG5 protein results in increased abundance of 3-Hydroxybutyric Acid CTD PMID:25943029 NCBI chr 6:106,184,476...106,325,789
Ensembl chr 6:106,045,423...106,325,791
JBrowse link
G BECN1 beclin 1 increases abundance EXP BECN1 protein results in increased abundance of 3-Hydroxybutyric Acid CTD PMID:25943029 NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350
JBrowse link
G CASP3 caspase 3 multiple interactions EXP
ISO
3-Hydroxybutyric Acid inhibits the reaction [Rotenone results in increased activity of CASP3 protein]
3-Hydroxybutyric Acid promotes the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased expression of CASP3 protein]
CTD PMID:16917840 PMID:31332890 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP8 caspase 8 multiple interactions ISO 3-Hydroxybutyric Acid promotes the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased expression of CASP8 protein] CTD PMID:31332890 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CASP9 caspase 9 multiple interactions EXP
ISO
3-Hydroxybutyric Acid inhibits the reaction [Rotenone results in increased activity of CASP9 protein]
3-Hydroxybutyric Acid promotes the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased expression of CASP9 protein]
CTD PMID:16917840 PMID:31332890 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CYP3A7-CYP3A51P CYP3A7-CYP3A51P readthrough multiple interactions ISO [[CYP3A11 protein co-treated with CYP3A16 protein co-treated with CYP3A25 protein co-treated with CYP3A41A protein co-treated with CYP3A44 protein co-treated with CYP3A57 protein co-treated with CYP3A59 protein] affects the susceptibility to Dietary Fats] which affects the abundance of 3-Hydroxybutyric Acid CTD PMID:29738703 NCBI chr 7:99,684,677...99,735,196
Ensembl chr 7:99,684,957...99,735,102
Ensembl chr 7:99,684,957...99,735,102
JBrowse link
G ERCC6 ERCC excision repair 6, chromatin remodeling factor multiple interactions
decreases abundance
EXP
ISO
3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A]; 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased expression of SIRT1 protein]; 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased expression of UCP2 protein]; 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]; 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in increased acetylation of TP53 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]]
ERCC6 gene mutant form results in decreased abundance of 3-Hydroxybutyric Acid
Dietary Fats inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of 3-Hydroxybutyric Acid]
CTD PMID:25440059 NCBI chr10:49,434,881...49,539,538
Ensembl chr10:49,454,470...49,539,538
Ensembl chr10:49,454,470...49,539,538
JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO 3-Hydroxybutyric Acid promotes the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased expression of GPT protein] CTD PMID:31332890 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174
JBrowse link
G HCAR2 hydroxycarboxylic acid receptor 2 increases activity
multiple interactions
EXP 3-Hydroxybutyric Acid results in increased activity of HCAR2 protein
3-Hydroxybutyric Acid binds to and results in increased activity of HCAR2 protein; [3-Hydroxybutyric Acid results in increased activity of HCAR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]
CTD PMID:15929991 PMID:19223991 NCBI chr12:122,701,293...122,703,357
Ensembl chr12:122,701,293...122,703,357
JBrowse link
G HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 increases secretion EXP HMGCS2 protein results in increased secretion of 3-Hydroxybutyric Acid CTD PMID:27816970 NCBI chr 1:119,747,996...119,768,932
Ensembl chr 1:119,748,002...119,768,905
Ensembl chr 1:119,748,002...119,768,905
JBrowse link
G IL6 interleukin 6 multiple interactions ISO 3-Hydroxybutyric Acid promotes the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased expression of IL6 protein] CTD PMID:31332890 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 multiple interactions ISO [NFE2L2 protein mutant form co-treated with Streptozocin] results in increased abundance of 3-Hydroxybutyric Acid CTD PMID:20086057 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions EXP [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased abundance of 3-Hydroxybutyric Acid CTD PMID:20404010 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
G SIRT1 sirtuin 1 multiple interactions EXP 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased expression of SIRT1 protein] CTD PMID:25440059 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
JBrowse link
G SLC13A5 solute carrier family 13 member 5 decreases abundance EXP SLC13A5 protein results in decreased abundance of 3-Hydroxybutyric Acid CTD PMID:32634519 NCBI chr17:6,684,719...6,713,400
Ensembl chr17:6,684,719...6,713,377
Ensembl chr17:6,684,719...6,713,377
JBrowse link
G SNCA synuclein alpha multiple interactions EXP 3-Hydroxybutyric Acid inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone]; 3-Hydroxybutyric Acid promotes the reaction [ursodoxicoltaurine inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone]] CTD PMID:16239214 NCBI chr 4:89,724,099...89,838,324
Ensembl chr 4:89,700,345...89,838,315
Ensembl chr 4:89,700,345...89,838,315
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO 3-Hydroxybutyric Acid promotes the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased expression of TNF protein] CTD PMID:31332890 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TP53 tumor protein p53 multiple interactions EXP 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in increased acetylation of TP53 protein] CTD PMID:25440059 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G UCP2 uncoupling protein 2 multiple interactions EXP 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased expression of UCP2 protein] CTD PMID:25440059 NCBI chr11:73,974,671...73,983,202
Ensembl chr11:73,974,672...73,983,246
Ensembl chr11:73,974,672...73,983,246
JBrowse link
3-hydroxyisovaleric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions ISO [Dexamethasone co-treated with beta-hydroxyisovaleric acid] results in increased phosphorylation of AKT1 protein CTD PMID:24124592 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G FBXO32 F-box protein 32 increases expression
multiple interactions
ISO beta-hydroxyisovaleric acid results in increased expression of FBXO32 mRNA
beta-hydroxyisovaleric acid inhibits the reaction [Dexamethasone results in increased expression of FBXO32 mRNA]
CTD PMID:24124592 NCBI chr 8:123,497,889...123,541,206
Ensembl chr 8:123,497,889...123,541,206
JBrowse link
G USP16 ubiquitin specific peptidase 16 increases expression ISO beta-hydroxyisovaleric acid results in increased expression of USP16 mRNA CTD PMID:24124592 NCBI chr21:29,024,651...29,054,488
Ensembl chr21:29,024,629...29,054,488
JBrowse link
G USP2 ubiquitin specific peptidase 2 increases expression ISO beta-hydroxyisovaleric acid results in increased expression of USP2 mRNA CTD PMID:24124592 NCBI chr11:119,355,215...119,381,690
Ensembl chr11:119,355,215...119,381,711
JBrowse link
G USP28 ubiquitin specific peptidase 28 increases expression ISO beta-hydroxyisovaleric acid results in increased expression of USP28 mRNA CTD PMID:24124592 NCBI chr11:113,797,875...113,875,572
Ensembl chr11:113,797,874...113,875,570
JBrowse link
3-hydroxypyruvic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH2 aldehyde dehydrogenase 2 family member multiple interactions ISO [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to hydroxypyruvic acid CTD PMID:21376711 NCBI chr12:111,766,933...111,817,532
Ensembl chr12:111,766,887...111,817,532
JBrowse link
G CAT catalase decreases response to substance ISO CAT protein results in decreased susceptibility to hydroxypyruvic acid CTD PMID:21376711 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
atropine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
EXP Atropine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Atropine results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 2:168,915,468...169,031,396
Ensembl chr 2:168,915,498...169,031,324
JBrowse link
G ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions EXP [Parathion co-treated with Atropine] results in increased expression of ABL1 mRNA CTD PMID:17390078 NCBI chr 9:130,713,043...130,887,675
Ensembl chr 9:130,713,016...130,887,675
JBrowse link
G ACHE acetylcholinesterase (Cartwright blood group) multiple interactions EXP
ISO
Atropine inhibits the reaction [[Organophosphorus Compounds results in decreased activity of ACHE protein] which results in increased abundance of Acetylcholine]; Atropine inhibits the reaction [Carbachol results in increased metabolism of and results in increased secretion of ACHE protein]; Atropine inhibits the reaction [Paraoxon results in increased expression of ACHE protein]
[Atropine co-treated with Obidoxime Chloride] inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of ACHE protein; [Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein; [pralidoxime co-treated with Atropine] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; [tariquidar co-treated with asoxime chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; Atropine inhibits the reaction [Methyl Parathion results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [[Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [[Atropine co-treated with Curcumin] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]]
[1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [[1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide co-treated with cucurbit(7)uril] co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; Atropine inhibits the reaction [Sarin results in decreased activity of ACHE protein]; Atropine promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; Atropine promotes the reaction [haloxon results in increased phosphorylation of ACHE protein]; Atropine promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein]
CTD PMID:2241428 PMID:10421444 PMID:17963125 PMID:20105433 PMID:21600273 PMID:21787676 PMID:22783142 PMID:23047022 PMID:24881594 PMID:26751814 PMID:31794810 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G ADCY5 adenylate cyclase 5 increases response to substance ISO ADCY5 protein results in increased susceptibility to Atropine CTD PMID:12869393 NCBI chr 3:123,282,296...123,449,090
Ensembl chr 3:123,282,296...123,449,090
Ensembl chr 3:123,282,296...123,449,090
JBrowse link
G AQP5 aquaporin 5 multiple interactions ISO Atropine inhibits the reaction [Pilocarpine affects the localization of AQP5 protein] CTD PMID:26208470 NCBI chr12:49,961,855...49,965,682
Ensembl chr12:49,961,872...49,965,682
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the expression of BAX mRNA] CTD PMID:21971501 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCAR1 BCAR1 scaffold protein, Cas family member multiple interactions EXP Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]] CTD PMID:10537051 NCBI chr16:75,228,181...75,268,007
Ensembl chr16:75,228,181...75,268,053
JBrowse link
G BCHE butyrylcholinesterase multiple interactions ISO
EXP
[Atropine co-treated with pralidoxime] results in decreased expression of BCHE protein; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of BCHE protein
[BCHE protein co-treated with asoxime chloride co-treated with pro-diazepam co-treated with Atropine] results in decreased susceptibility to VX
CTD PMID:17963125 PMID:22981459 NCBI chr 3:165,772,904...165,837,423
Ensembl chr 3:165,772,904...165,837,462
JBrowse link
G BDKRB2 bradykinin receptor B2 multiple interactions ISO BDKRB2 affects the susceptibility to [Propranolol co-treated with Atropine] CTD PMID:10614985 NCBI chr14:96,204,839...96,244,164
Ensembl chr14:96,204,679...96,244,166
JBrowse link
G BMP6 bone morphogenetic protein 6 multiple interactions ISO Atropine inhibits the reaction [Carbon Tetrachloride results in increased expression of BMP6 mRNA] CTD PMID:18472332 NCBI chr 6:7,726,099...7,881,728
Ensembl chr 6:7,726,099...7,881,728
JBrowse link
G CACNA1E calcium voltage-gated channel subunit alpha1 E multiple interactions ISO Atropine inhibits the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]] CTD PMID:12663092 NCBI chr 1:181,317,712...181,808,084
Ensembl chr 1:181,317,690...181,808,084
JBrowse link
G CALCA calcitonin related polypeptide alpha affects activity ISO Atropine affects the activity of CALCA protein CTD PMID:7906887 PMID:10075105 NCBI chr11:14,966,668...14,972,361
Ensembl chr11:14,966,668...14,972,354
Ensembl chr11:14,966,668...14,972,354
JBrowse link
G CASP3 caspase 3 increases expression ISO Atropine results in increased expression of CASP3 mRNA CTD PMID:19815060 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CCL5 C-C motif chemokine ligand 5 multiple interactions ISO [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 protein] CTD PMID:22245128 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793
JBrowse link
G CCNA1 cyclin A1 increases expression
multiple interactions
EXP Atropine results in increased expression of CCNA1 mRNA
[Parathion co-treated with Atropine] results in increased expression of CCNA1 mRNA
CTD PMID:17390078 NCBI chr13:36,430,488...36,442,870
Ensembl chr13:36,431,520...36,442,870
JBrowse link
G CCND3 cyclin D3 multiple interactions EXP [Parathion co-treated with Atropine] results in increased expression of CCND3 mRNA CTD PMID:17390078 NCBI chr 6:41,934,933...42,048,894
Ensembl chr 6:41,934,933...42,050,357
Ensembl chr 6:41,934,933...42,050,357
JBrowse link
G CCNE1 cyclin E1 increases expression
multiple interactions
EXP Atropine results in increased expression of CCNE1 mRNA
[Parathion co-treated with Atropine] results in increased expression of CCNE1 mRNA
CTD PMID:17390078 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312
JBrowse link
G CCNE2 cyclin E2 multiple interactions
increases expression
EXP [Parathion co-treated with Atropine] results in increased expression of CCNE2 mRNA
Atropine results in increased expression of CCNE2 mRNA
CTD PMID:17390078 NCBI chr 8:94,880,224...94,896,671
Ensembl chr 8:94,879,770...94,896,678
JBrowse link
G CD40 CD40 molecule multiple interactions EXP Atropine inhibits the reaction [Carbachol results in increased expression of CD40 protein] CTD PMID:16879495 NCBI chr20:46,118,242...46,129,858
Ensembl chr20:46,118,278...46,129,863
JBrowse link
G CDC20 cell division cycle 20 multiple interactions
increases expression
EXP [Parathion co-treated with Atropine] results in increased expression of CDC20 mRNA
Atropine results in increased expression of CDC20 mRNA
CTD PMID:17390078 NCBI chr 1:43,358,981...43,363,203
Ensembl chr 1:43,358,981...43,363,203
JBrowse link
G CDC6 cell division cycle 6 multiple interactions EXP [Parathion co-treated with Atropine] results in increased expression of CDC6 mRNA CTD PMID:17390078 NCBI chr17:40,287,878...40,304,657
Ensembl chr17:40,287,879...40,304,657
JBrowse link
G CDK1 cyclin dependent kinase 1 multiple interactions
increases expression
EXP [Parathion co-treated with Atropine] results in increased expression of CDK1 mRNA
Atropine results in increased expression of CDK1 mRNA
CTD PMID:17390078 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852
JBrowse link
G CES1 carboxylesterase 1 multiple interactions EXP Atropine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate] CTD PMID:9311626 NCBI chr16:55,802,851...55,833,127
Ensembl chr16:55,802,851...55,833,337
JBrowse link
G CHRM1 cholinergic receptor muscarinic 1 multiple interactions
decreases activity
ISO
EXP
Atropine binds to and results in decreased activity of CHRM1 protein; Atropine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]
Atropine results in decreased activity of CHRM1 protein
Atropine affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]
CTD PMID:16439611 PMID:18316702 PMID:31830555 NCBI chr11:62,908,675...62,921,861
Ensembl chr11:62,908,679...62,921,807
JBrowse link
G CHRM2 cholinergic receptor muscarinic 2 multiple interactions EXP Atropine binds to and results in decreased activity of CHRM2 protein CTD PMID:15140916 NCBI chr 7:136,868,652...137,020,213
Ensembl chr 7:136,868,669...137,020,255
Ensembl chr 7:136,868,669...137,020,255
JBrowse link
G CHRM3 cholinergic receptor muscarinic 3 multiple interactions
decreases activity
EXP Atropine binds to and results in decreased activity of CHRM3 protein; Atropine inhibits the reaction [Carbachol results in increased activity of CHRM3 protein]
Atropine results in decreased activity of CHRM3 protein
CTD PMID:15140916 PMID:20708676 PMID:31830555 NCBI chr 1:239,386,565...239,915,450
Ensembl chr 1:239,386,565...239,915,452
JBrowse link
G CHRM4 cholinergic receptor muscarinic 4 multiple interactions
affects binding
EXP [WIN 62577 co-treated with Quinuclidinyl Benzilate] inhibits the reaction [Atropine binds to CHRM4 protein] CTD PMID:16709648 NCBI chr11:46,383,789...46,391,776
Ensembl chr11:46,385,098...46,386,608
JBrowse link
G CHRM5 cholinergic receptor muscarinic 5 multiple interactions EXP Atropine inhibits the reaction [Acetylcholine results in increased activity of CHRM5 protein] CTD PMID:31323226 NCBI chr15:33,968,497...34,067,458
Ensembl chr15:33,968,497...34,067,458
Ensembl chr15:33,968,497...34,067,458
JBrowse link
G CHRNA4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions
affects binding
EXP
ISO
Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 protein]]
Atropine binds to [CHRNA4 protein binds to CHRNB2 protein]
CTD PMID:15733544 PMID:21791372 NCBI chr20:63,343,223...63,375,471
Ensembl chr20:63,343,223...63,378,401
JBrowse link
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit affects binding
multiple interactions
EXP
ISO
Atropine binds to [CHRNA4 protein binds to CHRNB2 protein]
Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 protein]]
Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
CTD PMID:15733544 PMID:21791372 NCBI chr 1:154,567,778...154,584,708
Ensembl chr 1:154,567,778...154,580,013
JBrowse link
G CREB1 cAMP responsive element binding protein 1 multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of CREB1 protein] CTD PMID:21971501 NCBI chr 2:207,529,943...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G CRH corticotropin releasing hormone multiple interactions ISO
EXP
Atropine inhibits the reaction [acephate results in increased expression of CRH mRNA]; Atropine inhibits the reaction [acephate results in increased secretion of CRH protein]; Atropine inhibits the reaction [methamidophos results in increased expression of CRH mRNA]; Atropine inhibits the reaction [methamidophos results in increased secretion of CRH protein]
[Atropine co-treated with SR 140333 co-treated with SR 48968] results in decreased activity of CRH protein
CTD PMID:12039681 PMID:12906840 NCBI chr 8:66,176,376...66,178,464
Ensembl chr 8:66,176,376...66,178,464
JBrowse link
G CTNNB1 catenin beta 1 multiple interactions EXP Atropine inhibits the reaction [Parathion results in increased expression of CTNNB1 protein mutant form]; Atropine inhibits the reaction [Parathion results in increased expression of CTNNB1 protein] CTD PMID:17390078 NCBI chr 3:41,199,422...41,240,445
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 multiple interactions ISO [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 protein] CTD PMID:22245128 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308
JBrowse link
G DVL2 dishevelled segment polarity protein 2 multiple interactions EXP Atropine inhibits the reaction [Parathion results in increased expression of DVL2 protein] CTD PMID:17390078 NCBI chr17:7,225,341...7,234,544
Ensembl chr17:7,225,342...7,234,517
JBrowse link
G EDN1 endothelin 1 multiple interactions EXP EDN1 protein results in decreased activity of [Atropine co-treated with Histamine] CTD PMID:12906840 NCBI chr 6:12,256,463...12,297,194
Ensembl chr 6:12,290,361...12,297,194
JBrowse link
G EGFR epidermal growth factor receptor multiple interactions EXP Atropine inhibits the reaction [Parathion results in increased expression of EGFR protein] CTD PMID:17390078 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G EGR1 early growth response 1 multiple interactions ISO Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR1 mRNA] CTD PMID:7968354 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
JBrowse link
G EGR2 early growth response 2 multiple interactions ISO Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA] CTD PMID:7968354 NCBI chr10:62,811,996...62,819,167
Ensembl chr10:62,811,996...62,919,900
JBrowse link
G EZR ezrin multiple interactions EXP Atropine inhibits the reaction [Parathion results in increased expression of EZR protein] CTD PMID:17390078 NCBI chr 6:158,765,744...158,819,368
Ensembl chr 6:158,765,741...158,819,368
JBrowse link
G F2 coagulation factor II, thrombin multiple interactions ISO [Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in decreased expression of F2 mRNA; [Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in increased activity of F2 protein CTD PMID:30515700 NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506
Ensembl chr11:46,719,196...46,739,506
JBrowse link
G F2R coagulation factor II thrombin receptor multiple interactions ISO [Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in increased expression of F2R protein CTD PMID:30515700 NCBI chr 5:76,716,126...76,735,770
Ensembl chr 5:76,716,126...76,735,770
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
ISO
EXP
Atropine results in increased expression of FOS protein
Atropine inhibits the reaction [Paraoxon results in increased expression of FOS mRNA]
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased expression of FOS protein]; Atropine inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]
CTD PMID:7968354 PMID:8281324 PMID:21787676 PMID:21971501 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G GHRL ghrelin and obestatin prepropeptide multiple interactions ISO Atropine inhibits the reaction [[Pentobarbital co-treated with L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide] results in increased expression of GHRL protein] CTD PMID:16959836 NCBI chr 3:10,285,666...10,292,947
Ensembl chr 3:10,285,666...10,292,947
JBrowse link
G GLRA1 glycine receptor alpha 1 multiple interactions EXP Atropine binds to and results in decreased activity of GLRA1 protein CTD PMID:15081878 NCBI chr 5:151,822,513...151,924,851
Ensembl chr 5:151,822,513...151,924,842
Ensembl chr 5:151,822,513...151,924,842
JBrowse link
G GRM4 glutamate metabotropic receptor 4 multiple interactions EXP Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] CTD PMID:18171729 NCBI chr 6:34,018,643...34,155,622
Ensembl chr 6:34,018,643...34,155,622
Ensembl chr 6:34,018,643...34,155,622
JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions ISO [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of ICAM1 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of ICAM1 protein] CTD PMID:22245128 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of IL1B mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of IL1B protein] CTD PMID:22245128 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 multiple interactions ISO [Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 mRNA]; [Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 protein] CTD PMID:22245128 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of JUN protein] CTD PMID:21971501 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
JBrowse link
G JUNB JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Atropine inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA] CTD PMID:7968354 NCBI chr19:12,791,486...12,793,315
Ensembl chr19:12,791,486...12,793,315
JBrowse link
G KCNJ3 potassium inwardly rectifying channel subfamily J member 3 multiple interactions EXP Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] CTD PMID:18171729 NCBI chr 2:154,698,695...154,858,354
Ensembl chr 2:154,697,855...154,858,354
JBrowse link
G KIT KIT proto-oncogene, receptor tyrosine kinase multiple interactions EXP Atropine inhibits the reaction [Parathion results in increased expression of KIT protein] CTD PMID:17390078 NCBI chr 4:54,657,957...54,740,715
Ensembl chr 4:54,657,918...54,740,715
JBrowse link
G LTF lactotransferrin multiple interactions EXP Atropine inhibits the reaction [methylcholine results in increased secretion of LTF protein] CTD PMID:11112886 NCBI chr 3:46,435,645...46,485,234
Ensembl chr 3:46,435,645...46,485,234
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK1 protein] CTD PMID:21971501 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK14 mitogen-activated protein kinase 14 multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK14 protein] CTD PMID:21971501 NCBI chr 6:36,027,711...36,122,964
Ensembl chr 6:36,027,677...36,111,236
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK3 protein] CTD PMID:21971501 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK8 protein] CTD PMID:21971501 NCBI chr10:48,306,673...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MCM4 minichromosome maintenance complex component 4 multiple interactions
increases expression
EXP [Parathion co-treated with Atropine] results in increased expression of MCM4 mRNA
Atropine results in increased expression of MCM4 mRNA
CTD PMID:17390078 NCBI chr 8:47,960,941...47,978,160
Ensembl chr 8:47,960,185...47,978,160
JBrowse link
G MCM6 minichromosome maintenance complex component 6 increases expression
multiple interactions
EXP Atropine results in increased expression of MCM6 mRNA
[Parathion co-treated with Atropine] results in increased expression of MCM6 mRNA
CTD PMID:17390078 NCBI chr 2:135,839,626...135,876,443
Ensembl chr 2:135,839,626...135,876,443
JBrowse link
G NEFH neurofilament heavy chain affects expression ISO Atropine affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr22:29,480,218...29,491,390
Ensembl chr22:29,480,218...29,491,390
JBrowse link
G NLRP3 NLR family pyrin domain containing 3 increases expression EXP Atropine results in increased expression of NLRP3 mRNA CTD PMID:28138970 NCBI chr 1:247,416,163...247,448,823
Ensembl chr 1:247,416,156...247,449,108
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO Atropine inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; Atropine inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA] CTD PMID:15610444 PMID:16944022 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NOTCH4 notch receptor 4 multiple interactions EXP Atropine inhibits the reaction [Parathion results in increased expression of NOTCH4 protein] CTD PMID:17390078 NCBI chr 6:32,194,843...32,224,067
Ensembl chr 6:32,194,843...32,224,067
JBrowse link
G NPPA natriuretic peptide A affects activity ISO Atropine affects the activity of NPPA protein modified form CTD PMID:1363893 NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345
JBrowse link
G OPRL1 opioid related nociceptin receptor 1 multiple interactions ISO Atropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein] CTD PMID:12007927 NCBI chr20:64,080,082...64,100,643
Ensembl chr20:64,080,082...64,100,643
JBrowse link
G PCNA proliferating cell nuclear antigen multiple interactions EXP Atropine inhibits the reaction [Malathion results in increased expression of PCNA]; Atropine inhibits the reaction [Parathion results in increased expression of PCNA] CTD PMID:12762645 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
JBrowse link
G PNOC prepronociceptin multiple interactions ISO Atropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein] CTD PMID:12007927 NCBI chr 8:28,316,979...28,343,355
Ensembl chr 8:28,316,986...28,343,355
JBrowse link
G POMC proopiomelanocortin multiple interactions ISO Atropine inhibits the reaction [Acetylcholine results in increased expression of POMC protein] CTD PMID:7588217 NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions ISO [Atropine co-treated with Glucose] binds to PPARA protein; Atropine inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]] CTD PMID:18812576 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Atropine affects the reaction [Indomethacin results in increased expression of PTGS2]; Atropine inhibits the reaction [Indomethacin results in increased expression of PTGS2 mRNA]; Atropine inhibits the reaction [Indomethacin results in increased expression of PTGS2]; Atropine inhibits the reaction [SC 560 results in increased expression of PTGS2 mRNA] CTD PMID:15104355 PMID:15610444 PMID:16259740 PMID:16804302 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G PTK2 protein tyrosine kinase 2 multiple interactions EXP Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein]] CTD PMID:10537051 NCBI chr 8:140,657,900...141,002,079
Ensembl chr 8:140,657,900...141,002,216
JBrowse link
G PXN paxillin multiple interactions EXP Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]] CTD PMID:10537051 NCBI chr12:120,210,447...120,265,737
Ensembl chr12:120,210,439...120,265,771
JBrowse link
G RAC3 Rac family small GTPase 3 multiple interactions EXP Atropine inhibits the reaction [Parathion results in increased expression of RAC3 protein] CTD PMID:17390078 NCBI chr17:82,031,678...82,034,204
Ensembl chr17:82,031,678...82,034,204
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of RELA protein] CTD PMID:21971501 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G RHOA ras homolog family member A multiple interactions EXP Atropine inhibits the reaction [Parathion results in increased expression of RHOA protein] CTD PMID:17390078 NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,145...49,412,998
Ensembl chr 3:49,359,145...49,412,998
JBrowse link
G SLC22A1 solute carrier family 22 member 1 multiple interactions EXP Atropine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Atropine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:16263091 PMID:21641380 NCBI chr 6:160,121,808...160,160,590
Ensembl chr 6:160,121,815...160,158,718
JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP Atropine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Atropine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Atropine inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium] CTD PMID:16263091 PMID:21599003 PMID:23770354 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638
JBrowse link
G SLC22A3 solute carrier family 22 member 3 increases uptake
multiple interactions
EXP SLC22A3 protein results in increased uptake of Atropine
Atropine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]
CTD PMID:16263091 NCBI chr 6:160,348,378...160,454,982
Ensembl chr 6:160,348,378...160,452,577
JBrowse link
G SLC22A4 solute carrier family 22 member 4 multiple interactions EXP Atropine inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium] CTD PMID:21641380 NCBI chr 5:132,294,384...132,344,199
Ensembl chr 5:132,294,394...132,344,190
JBrowse link
G SLC47A1 solute carrier family 47 member 1 multiple interactions EXP Atropine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr17:19,533,854...19,579,034
Ensembl chr17:19,495,385...19,579,034
JBrowse link
G SLC47A2 solute carrier family 47 member 2 multiple interactions EXP Atropine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr17:19,678,313...19,719,598
Ensembl chr17:19,678,288...19,718,979
JBrowse link
G SLPI secretory leukocyte peptidase inhibitor increases expression EXP Atropine results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr20:45,252,239...45,254,564
Ensembl chr20:45,252,239...45,254,564
JBrowse link
G SOCS3 suppressor of cytokine signaling 3 multiple interactions ISO [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of SOCS3 mRNA] CTD PMID:22245128 NCBI chr17:78,356,778...78,360,925
Ensembl chr17:78,356,778...78,360,077
JBrowse link
G SPN sialophorin increases response to substance ISO SPN protein results in increased susceptibility to Atropine CTD PMID:18711009 NCBI chr16:29,662,963...29,670,876
Ensembl chr16:29,662,979...29,670,876
JBrowse link
G TAT tyrosine aminotransferase multiple interactions ISO [Atropine co-treated with Obidoxime Chloride co-treated with Diazepam] inhibits the reaction [Dichlorvos results in increased expression of TAT protein] CTD PMID:7761789 NCBI chr16:71,565,660...71,577,092
Ensembl chr16:71,565,660...71,577,092
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO Atropine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA] CTD PMID:18472332 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of TNF mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of TNF protein] CTD PMID:22245128 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TP53 tumor protein p53 multiple interactions EXP Atropine inhibits the reaction [Malathion results in increased expression of TP53 protein]; Atropine inhibits the reaction [Parathion results in increased expression of TP53 protein] CTD PMID:12762645 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TRIO trio Rho guanine nucleotide exchange factor multiple interactions EXP Atropine inhibits the reaction [Parathion results in increased expression of TRIO protein] CTD PMID:17390078 NCBI chr 5:14,143,342...14,510,204
Ensembl chr 5:14,143,342...14,532,128
JBrowse link
G TRPA1 transient receptor potential cation channel subfamily A member 1 decreases response to substance ISO TRPA1 gene mutant form results in decreased susceptibility to Atropine CTD PMID:29627347 NCBI chr 8:72,021,250...72,094,885
Ensembl chr 8:72,019,917...72,075,584
JBrowse link
G TSHB thyroid stimulating hormone subunit beta multiple interactions ISO [pralidoxime co-treated with Atropine] inhibits the reaction [methamidophos results in decreased expression of TSHB protein] CTD PMID:15891268 NCBI chr 1:115,029,826...115,035,935
Ensembl chr 1:115,029,826...115,034,302
Ensembl chr 1:115,029,826...115,034,302
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions ISO [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of VCAM1 mRNA] CTD PMID:22245128 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045
JBrowse link
beta-propiolactone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NFE2L2 nuclear factor, erythroid 2 like 2 decreases response to substance ISO NFE2L2 protein results in decreased susceptibility to Propiolactone CTD PMID:20932822 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
propetamphos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAT catalase decreases activity
multiple interactions
ISO propetamphos results in decreased activity of CAT protein
[cypermethrin co-treated with propetamphos] results in decreased activity of CAT protein
[propetamphos co-treated with cypermethrin] results in decreased activity of CAT protein
CTD PMID:18214882 PMID:25926273 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CYCS cytochrome c, somatic multiple interactions
increases activity
ISO [propetamphos co-treated with cypermethrin] results in increased activity of CYCS protein
propetamphos results in increased activity of CYCS protein
CTD PMID:25926273 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions
increases activity
ISO [cypermethrin co-treated with propetamphos] results in increased activity of CYP2E1 protein
propetamphos results in increased activity of CYP2E1 protein
CTD PMID:25926273 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase multiple interactions
decreases activity
ISO [cypermethrin co-treated with propetamphos] results in decreased activity of G6PD protein
propetamphos results in decreased activity of G6PD protein
CTD PMID:25926273 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,531,391...154,547,572
JBrowse link
scopolamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 decreases expression ISO Scopolamine results in decreased expression of ABCB1 mRNA CTD PMID:12818353 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ABCG1 ATP binding cassette subfamily G member 1 increases expression ISO Scopolamine results in increased expression of ABCG1 mRNA CTD PMID:12818353 NCBI chr21:42,199,689...42,304,387
Ensembl chr21:42,199,689...42,297,244
JBrowse link
G ACHE acetylcholinesterase (Cartwright blood group) multiple interactions
increases expression
affects activity
increases activity
decreases activity
decreases expression
increases response to substance
affects response to substance
EXP
ISO
kangshuai yizhi inhibits the reaction [Scopolamine results in increased activity of ACHE protein]
Scopolamine results in increased expression of ACHE mRNA; Scopolamine results in increased expression of ACHE protein
Scopolamine affects the activity of ACHE protein
Scopolamine results in decreased activity of ACHE protein
Ascorbic Acid inhibits the reaction [Scopolamine results in decreased activity of ACHE protein]; Canagliflozin inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Galantamine inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; stevioside inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Vitamin E inhibits the reaction [Scopolamine results in decreased activity of ACHE protein]
Scopolamine results in decreased expression of ACHE protein
ACHE protein results in increased susceptibility to Scopolamine
7-fluoro-1,3-diphenylisoquinoline-1-amine inhibits the reaction [Scopolamine results in increased expression of ACHE protein]; acanthoside B inhibits the reaction [Scopolamine results in increased expression of ACHE protein]; ajoene inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; chong-myung-tang inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; mangiferin inhibits the reaction [Scopolamine results in decreased expression of ACHE protein]; Piracetam inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Plant Extracts affects the reaction [Scopolamine affects the activity of ACHE protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased expression of ACHE mRNA]; protopanaxadiol inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Serotonin analog inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of ACHE protein]
ACHE affects the susceptibility to Scopolamine
CTD PMID:11814146 PMID:15301936 PMID:18533140 PMID:18672024 PMID:20673844 PMID:20694781 PMID:20871768 PMID:22426032 PMID:26408985 PMID:26434561 PMID:27717698 PMID:28837785 PMID:29133030 PMID:31077737 PMID:32001261 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G ADORA3 adenosine A3 receptor multiple interactions ISO [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein] which results in decreased susceptibility to Scopolamine CTD PMID:12672554 NCBI chr 1:111,499,429...111,503,633
Ensembl chr 1:111,499,429...111,503,633
Ensembl chr 1:111,499,429...111,503,633
JBrowse link
G AGT angiotensinogen multiple interactions EXP [AGT protein modified form binds to and results in decreased activity of LNPEP protein] which results in decreased susceptibility to Scopolamine CTD PMID:11707427 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,702,523...230,714,122
Ensembl chr 1:230,702,523...230,714,122
JBrowse link
G APBA1 amyloid beta precursor protein binding family A member 1 increases expression ISO Scopolamine results in increased expression of APBA1 mRNA CTD PMID:12818353 NCBI chr 9:69,427,532...69,673,012
Ensembl chr 9:69,427,532...69,672,371
JBrowse link
G APLP2 amyloid beta precursor like protein 2 increases expression ISO Scopolamine results in increased expression of APLP2 mRNA CTD PMID:12818353 NCBI chr11:130,069,894...130,144,805
Ensembl chr11:130,068,147...130,144,811
JBrowse link
G APP amyloid beta precursor protein decreases cleavage ISO Scopolamine results in decreased cleavage of APP protein CTD PMID:16423497 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
G ARC activity regulated cytoskeleton associated protein decreases expression ISO Scopolamine results in decreased expression of ARC mRNA CTD PMID:17540011 NCBI chr 8:142,611,049...142,614,479
Ensembl chr 8:142,611,049...142,614,479
JBrowse link
G ARG2 arginase 2 decreases expression ISO Scopolamine results in decreased expression of ARG2 mRNA CTD PMID:12818353 NCBI chr14:67,619,920...67,651,708
Ensembl chr14:67,619,920...67,651,708
JBrowse link
G ARL4D ADP ribosylation factor like GTPase 4D decreases expression ISO Scopolamine results in decreased expression of ARL4D mRNA CTD PMID:17540011 NCBI chr17:43,398,993...43,401,137
Ensembl chr17:43,398,993...43,401,137
JBrowse link
G AVP arginine vasopressin multiple interactions ISO [[[AVP binds to and results in increased activity of AVPR1A protein] which results in increased abundance of Calcium] which results in increased activity of CHRM1 protein] which results in decreased susceptibility to Scopolamine CTD PMID:11553362 NCBI chr20:3,082,556...3,093,521
Ensembl chr20:3,082,556...3,084,724
JBrowse link
G AVPR1A arginine vasopressin receptor 1A multiple interactions ISO [[[AVP binds to and results in increased activity of AVPR1A protein] which results in increased abundance of Calcium] which results in increased activity of CHRM1 protein] which results in decreased susceptibility to Scopolamine CTD PMID:11553362 NCBI chr12:63,142,759...63,151,201
Ensembl chr12:63,142,759...63,150,942
Ensembl chr12:63,142,759...63,150,942
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO Scopolamine results in increased expression of BAX mRNA; Scopolamine results in increased expression of BAX protein
Plant Extracts inhibits the reaction [Scopolamine results in increased expression of BAX mRNA]
CTD PMID:17120751 PMID:26434561 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCAT1 branched chain amino acid transaminase 1 increases expression ISO Scopolamine results in increased expression of BCAT1 mRNA CTD PMID:17540011 NCBI chr12:24,810,024...24,949,101
Ensembl chr12:24,810,024...24,949,101
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression ISO Scopolamine results in decreased expression of BCL2 mRNA; Scopolamine results in decreased expression of BCL2 protein CTD PMID:17120751 PMID:26434561 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BDNF brain derived neurotrophic factor multiple interactions
decreases expression
ISO Scopolamine inhibits the reaction [Dizocilpine Maleate affects the expression of BDNF mRNA]; Scopolamine inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA]
Scopolamine results in decreased expression of BDNF mRNA; Scopolamine results in decreased expression of BDNF protein
[acanthoside B co-treated with Scopolamine] results in increased expression of BDNF protein; [Tacrine co-treated with Scopolamine] results in increased expression of BDNF protein; Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of BDNF mRNA]; Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]; Melatonin inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]; Plant Extracts inhibits the reaction [Scopolamine results in decreased expression of BDNF mRNA]; Serotonin analog inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]; Tacrine inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]
CTD PMID:8405262 PMID:8635431 PMID:22096544 PMID:26408985 PMID:26434561 PMID:29476728 PMID:31077737 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058
JBrowse link
G CACNA1D calcium voltage-gated channel subunit alpha1 D increases expression ISO Scopolamine results in increased expression of CACNA1D mRNA CTD PMID:12818353 NCBI chr 3:53,494,611...53,813,733
Ensembl chr 3:53,328,963...53,813,733
JBrowse link
G CAMKK2 calcium/calmodulin dependent protein kinase kinase 2 decreases expression ISO Scopolamine results in decreased expression of CAMKK2 mRNA CTD PMID:17540011 NCBI chr12:121,237,692...121,297,819
Ensembl chr12:121,237,675...121,298,308
JBrowse link
G CARTPT CART prepropeptide decreases expression ISO Scopolamine results in decreased expression of CARTPT mRNA CTD PMID:17540011 NCBI chr 5:71,719,275...71,721,045
Ensembl chr 5:71,719,275...71,721,048
JBrowse link
G CASP3 caspase 3 increases expression
multiple interactions
ISO Scopolamine results in increased expression of CASP3 mRNA; Scopolamine results in increased expression of CASP3 protein
Plant Extracts inhibits the reaction [Scopolamine results in increased expression of CASP3 mRNA]
CTD PMID:17120751 PMID:26434561 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CAT catalase multiple interactions
increases activity
decreases activity
ISO acanthoside B inhibits the reaction [Scopolamine results in decreased activity of CAT protein]; chong-myung-tang inhibits the reaction [Scopolamine results in decreased activity of CAT protein]; Piracetam inhibits the reaction [Scopolamine results in increased activity of CAT protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased activity of CAT protein]; Tacrine inhibits the reaction [Scopolamine results in decreased activity of CAT protein] CTD PMID:20673844 PMID:27717698 PMID:31077737 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CD3E CD3e molecule decreases expression ISO Scopolamine results in decreased expression of CD3E mRNA CTD PMID:17540011 NCBI chr11:118,304,730...118,316,173
Ensembl chr11:118,304,730...118,316,175
Ensembl chr11:118,304,730...118,316,175
JBrowse link
G CDKL4 cyclin dependent kinase like 4 increases expression ISO Scopolamine results in increased expression of CDKL4 mRNA CTD PMID:17540011 NCBI chr 2:39,168,045...39,248,835
Ensembl chr 2:39,175,646...39,229,588
JBrowse link
G CHAT choline O-acetyltransferase decreases activity
multiple interactions
EXP
ISO
Scopolamine results in decreased activity of CHAT protein
protopanaxadiol inhibits the reaction [Scopolamine results in decreased activity of CHAT protein]; Serotonin analog inhibits the reaction [Scopolamine results in decreased activity of CHAT protein]
kangshuai yizhi inhibits the reaction [Scopolamine results in decreased activity of CHAT protein]
CTD PMID:20694781 PMID:26408985 PMID:29133030 NCBI chr10:49,609,095...49,667,942
Ensembl chr10:49,609,095...49,665,104
Ensembl chr10:49,609,095...49,665,104
JBrowse link
G CHRM1 cholinergic receptor muscarinic 1 multiple interactions
decreases expression
increases expression
ISO [[[AVP binds to and results in increased activity of AVPR1A protein] which results in increased abundance of Calcium] which results in increased activity of CHRM1 protein] which results in decreased susceptibility to Scopolamine; Canagliflozin affects the reaction [Scopolamine results in decreased expression of CHRM1 protein]
Scopolamine results in increased expression of CHRM1 mRNA
7-fluoro-1,3-diphenylisoquinoline-1-amine inhibits the reaction [Scopolamine results in decreased expression of CHRM1 protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased expression of CHRM1 mRNA]
CTD PMID:11553362 PMID:26434561 PMID:28837785 PMID:32001261 NCBI chr11:62,908,675...62,921,861
Ensembl chr11:62,908,679...62,921,807
JBrowse link
G CHRM4 cholinergic receptor muscarinic 4 increases response to substance ISO CHRM4 protein results in increased susceptibility to Scopolamine CTD PMID:12729838 NCBI chr11:46,383,789...46,391,776
Ensembl chr11:46,385,098...46,386,608
JBrowse link
G CHRM5 cholinergic receptor muscarinic 5 decreases response to substance ISO CHRM5 protein results in decreased susceptibility to Scopolamine CTD PMID:13679217 NCBI chr15:33,968,497...34,067,458
Ensembl chr15:33,968,497...34,067,458
Ensembl chr15:33,968,497...34,067,458
JBrowse link
G CHRNA4 cholinergic receptor nicotinic alpha 4 subunit affects binding
multiple interactions
EXP Scopolamine binds to [CHRNA4 protein binds to CHRNB2 protein]
Scopolamine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
CTD PMID:15733544 NCBI chr20:63,343,223...63,375,471
Ensembl chr20:63,343,223...63,378,401
JBrowse link
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit affects binding
multiple interactions
EXP Scopolamine binds to [CHRNA4 protein binds to CHRNB2 protein]
Scopolamine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
CTD PMID:15733544 NCBI chr 1:154,567,778...154,584,708
Ensembl chr 1:154,567,778...154,580,013
JBrowse link
G COCH cochlin decreases expression ISO Scopolamine results in decreased expression of COCH mRNA CTD PMID:12818353 NCBI chr14:30,874,496...30,890,618
Ensembl chr14:30,874,514...30,895,065
JBrowse link
G CORO1B coronin 1B increases expression ISO Scopolamine results in increased expression of CORO1B mRNA CTD PMID:12818353 NCBI chr11:67,435,510...67,443,809
Ensembl chr11:67,435,510...67,443,821
JBrowse link
G COX5B cytochrome c oxidase subunit 5B increases expression ISO Scopolamine results in increased expression of COX5B mRNA CTD PMID:12818353 NCBI chr 2:97,646,062...97,648,383
Ensembl chr 2:97,646,062...97,648,383
JBrowse link
G CREB1 cAMP responsive element binding protein 1 decreases phosphorylation
multiple interactions
ISO Scopolamine results in decreased phosphorylation of CREB1 protein
acanthoside B inhibits the reaction [Scopolamine results in decreased phosphorylation of CREB1 protein]; Serotonin analog inhibits the reaction [Scopolamine results in decreased phosphorylation of CREB1 protein]; Tacrine inhibits the reaction [Scopolamine results in decreased phosphorylation of CREB1 protein]
CTD PMID:26408985 PMID:31077737 NCBI chr 2:207,529,943...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G CRYAB crystallin alpha B increases expression ISO Scopolamine results in increased expression of CRYAB mRNA CTD PMID:17540011 NCBI chr11:111,908,564...111,923,740
Ensembl chr11:111,908,564...111,923,722
JBrowse link
G CSF2 colony stimulating factor 2 multiple interactions
decreases response to substance
ISO IL1RN protein inhibits the reaction [CSF2 protein results in decreased susceptibility to Scopolamine] CTD PMID:8877002 NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170
JBrowse link
G CXCR5 C-X-C motif chemokine receptor 5 decreases expression ISO Scopolamine results in decreased expression of CXCR5 mRNA CTD PMID:12818353 NCBI chr11:118,883,892...118,897,787
Ensembl chr11:118,883,892...118,897,787
JBrowse link
G DDC dopa decarboxylase decreases expression ISO Scopolamine results in decreased expression of DDC mRNA CTD PMID:17540011 NCBI chr 7:50,458,436...50,565,460
Ensembl chr 7:50,458,436...50,565,405
JBrowse link
G DGUOK deoxyguanosine kinase increases expression ISO Scopolamine results in increased expression of DGUOK mRNA CTD PMID:17540011 NCBI chr 2:73,926,827...73,958,961
Ensembl chr 2:73,926,826...73,958,961
JBrowse link
G DIO2 iodothyronine deiodinase 2 increases expression ISO Scopolamine results in increased expression of DIO2 mRNA CTD PMID:12818353 NCBI chr14:80,197,526...80,231,057
Ensembl chr14:80,197,527...80,387,757
Ensembl chr14:80,197,527...80,387,757
JBrowse link
G DUSP5 dual specificity phosphatase 5 decreases expression ISO Scopolamine results in decreased expression of DUSP5 mRNA CTD PMID:17540011 NCBI chr10:110,497,907...110,511,533
Ensembl chr10:110,497,907...110,511,533
JBrowse link
G DUSP6 dual specificity phosphatase 6 decreases expression ISO Scopolamine results in decreased expression of DUSP6 mRNA CTD PMID:17540011 NCBI chr12:89,347,235...89,352,501
Ensembl chr12:89,347,235...89,352,501
JBrowse link
G EGFR epidermal growth factor receptor decreases expression ISO Scopolamine results in decreased expression of EGFR mRNA CTD PMID:12818353 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G EGR1 early growth response 1 multiple interactions
decreases expression
ISO [Scopolamine co-treated with 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine] results in increased expression of EGR1 mRNA; Scopolamine affects the reaction [SK&F 82958 results in increased expression of EGR1 mRNA]
Scopolamine results in decreased expression of EGR1 protein
Donepezil inhibits the reaction [Scopolamine results in decreased expression of EGR1 protein]; protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of EGR1 protein]
Scopolamine results in decreased expression of EGR1 mRNA
CTD PMID:8861055 PMID:17540011 PMID:29133030 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
JBrowse link
G EGR2 early growth response 2 decreases expression ISO Scopolamine results in decreased expression of EGR2 mRNA CTD PMID:17540011 NCBI chr10:62,811,996...62,819,167
Ensembl chr10:62,811,996...62,919,900
JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha increases expression ISO Scopolamine results in increased expression of EIF2S1 mRNA CTD PMID:12818353 NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,151...67,386,516
Ensembl chr14:67,360,151...67,386,516
JBrowse link
G EML1 EMAP like 1 decreases expression ISO Scopolamine results in decreased expression of EML1 mRNA CTD PMID:17540011 NCBI chr14:99,737,722...99,942,060
Ensembl chr14:99,737,693...99,942,060
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression
increases expression
ISO [Scopolamine co-treated with 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine] results in increased expression of FOS mRNA; Physostigmine inhibits the reaction [Scopolamine promotes the reaction [SK&F 82958 results in increased expression of FOS mRNA]]; Ro4368554 inhibits the reaction [Scopolamine results in increased expression of FOS protein]; Scopolamine affects the reaction [SK&F 82958 results in increased expression of FOS mRNA]; Scopolamine inhibits the reaction [Haloperidol results in increased expression of FOS protein]; Scopolamine promotes the reaction [SK&F 82958 results in increased expression of FOS mRNA]
Scopolamine results in decreased expression of FOS protein
Donepezil inhibits the reaction [Scopolamine results in decreased expression of FOS protein]; protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of FOS protein]
Scopolamine results in decreased expression of FOS mRNA
CTD PMID:1393566 PMID:8281324 PMID:8861055 PMID:11337201 PMID:17540011 PMID:17920665 PMID:29133030 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G GABBR1 gamma-aminobutyric acid type B receptor subunit 1 increases expression ISO Scopolamine results in increased expression of GABBR1 mRNA CTD PMID:17540011 NCBI chr 6:29,602,230...29,633,183
Ensembl chr 6:29,555,629...29,633,976
JBrowse link
G GAP43 growth associated protein 43 multiple interactions
decreases expression
EXP Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of GAP43 protein]; withanone inhibits the reaction [Scopolamine results in decreased expression of GAP43 protein] CTD PMID:22096544 NCBI chr 3:115,623,510...115,721,485
Ensembl chr 3:115,623,324...115,721,490
Ensembl chr 3:115,623,324...115,721,490
JBrowse link
G GFAP glial fibrillary acidic protein multiple interactions
decreases expression
ISO Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of GFAP mRNA]; Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of GFAP protein]; withanone inhibits the reaction [Scopolamine results in decreased expression of GFAP protein]
Scopolamine results in decreased expression of GFAP mRNA; Scopolamine results in decreased expression of GFAP protein
CTD PMID:22096544 NCBI chr17:44,903,159...44,915,552
Ensembl chr17:44,903,159...44,916,937
JBrowse link
G GJB2 gap junction protein beta 2 increases expression ISO Scopolamine results in increased expression of GJB2 mRNA CTD PMID:17540011 NCBI chr13:20,187,470...20,192,938
Ensembl chr13:20,187,463...20,192,938
JBrowse link
G GPC3 glypican 3 decreases expression ISO Scopolamine results in decreased expression of GPC3 mRNA CTD PMID:12818353 NCBI chr  X:133,535,745...133,985,616
Ensembl chr  X:133,535,745...133,985,594
Ensembl chr  X:133,535,745...133,985,594
JBrowse link
G GRM4 glutamate metabotropic receptor 4 multiple interactions EXP Scopolamine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] CTD PMID:18171729 NCBI chr 6:34,018,643...34,155,622
Ensembl chr 6:34,018,643...34,155,622
Ensembl chr 6:34,018,643...34,155,622
JBrowse link
G GSR glutathione-disulfide reductase decreases activity
multiple interactions
ISO Scopolamine results in decreased activity of GSR protein
Serotonin analog inhibits the reaction [Scopolamine results in decreased activity of GSR protein]; Tacrine inhibits the reaction [Scopolamine results in decreased activity of GSR protein]
CTD PMID:26408985 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G GYPC glycophorin C (Gerbich blood group) decreases expression ISO Scopolamine results in decreased expression of GYPC mRNA CTD PMID:17540011 NCBI chr 2:126,656,158...126,696,668
Ensembl chr 2:126,656,133...126,696,667
JBrowse link
G HMOX1 heme oxygenase 1 increases expression
multiple interactions
ISO Scopolamine results in increased expression of HMOX1 protein
7-fluoro-1,3-diphenylisoquinoline-1-amine inhibits the reaction [Scopolamine results in increased expression of HMOX1 protein]
CTD PMID:32001261 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G HOMER1 homer scaffold protein 1 decreases expression ISO Scopolamine results in decreased expression of HOMER1 mRNA CTD PMID:17540011 NCBI chr 5:79,372,636...79,514,134
Ensembl chr 5:79,372,636...79,514,134
JBrowse link
G HRH1 histamine receptor H1 multiple interactions ISO [Histamine binds to and results in increased activity of HRH1 protein] which results in decreased susceptibility to Scopolamine; Pyrilamine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in decreased susceptibility to Scopolamine] CTD PMID:19215234 NCBI chr 3:11,137,238...11,263,557
Ensembl chr 3:11,137,093...11,263,557
JBrowse link
G HRH2 histamine receptor H2 multiple interactions ISO [[thioperamide results in increased abundance of Histamine] which results in increased activity of HRH2 protein] which results in decreased susceptibility to Scopolamine; Cimetidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH2 protein] which results in decreased susceptibility to Scopolamine] CTD PMID:11640976 PMID:19215234 NCBI chr 5:175,657,762...175,710,756
Ensembl chr 5:175,658,030...175,710,756
JBrowse link
G HRH3 histamine receptor H3 multiple interactions ISO [clobenpropit binds to and results in decreased activity of HRH3 protein] which results in decreased susceptibility to Scopolamine CTD PMID:16488453 NCBI chr20:62,213,845...62,220,278
Ensembl chr20:62,214,960...62,220,278
JBrowse link
G HSPA2 heat shock protein family A (Hsp70) member 2 increases expression ISO Scopolamine results in increased expression of HSPA2 mRNA CTD PMID:12818353 NCBI chr14:64,535,905...64,543,237
Ensembl chr14:64,535,905...64,546,173
JBrowse link
G HTR1A 5-hydroxytryptamine receptor 1A multiple interactions ISO [4-(benzodioxan-5-yl)-1-(indan-2-yl)piperazine binds to and results in increased activity of HTR1A] which results in decreased susceptibility to Scopolamine; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [[4-(benzodioxan-5-yl)-1-(indan-2-yl)piperazine binds to and results in increased activity of HTR1A] which results in decreased susceptibility to Scopolamine] CTD PMID:10578133 NCBI chr 5:63,957,874...63,962,445
Ensembl chr 5:63,960,356...63,962,507
Ensembl chr 5:63,960,356...63,962,507
JBrowse link
G HTR2C 5-hydroxytryptamine receptor 2C increases expression ISO Scopolamine results in increased expression of HTR2C mRNA CTD PMID:17540011 NCBI chr  X:114,584,086...114,910,061
Ensembl chr  X:114,584,078...114,910,061
JBrowse link
G HTR6 5-hydroxytryptamine receptor 6 decreases expression ISO Scopolamine results in decreased expression of HTR6 mRNA CTD PMID:19733250 NCBI chr 1:19,664,875...19,680,966
Ensembl chr 1:19,664,875...19,680,966
JBrowse link
G IFNG interferon gamma multiple interactions
increases expression
ISO Fatty Acids, Unsaturated deficiency promotes the reaction [Scopolamine results in increased expression of IFNG mRNA] CTD PMID:21161262 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL10 interleukin 10 multiple interactions
decreases expression
ISO acanthoside B inhibits the reaction [Scopolamine results in decreased expression of IL10 protein]; Tacrine inhibits the reaction [Scopolamine results in decreased expression of IL10 protein] CTD PMID:31077737 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL1A interleukin 1 alpha decreases response to substance ISO IL1A protein results in decreased susceptibility to Scopolamine CTD PMID:8003924 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G IL1B interleukin 1 beta increases expression
multiple interactions
ISO Scopolamine results in increased expression of IL1B mRNA; Scopolamine results in increased expression of IL1B protein
Fatty Acids, Unsaturated deficiency promotes the reaction [Scopolamine results in increased expression of IL1B mRNA]
acanthoside B inhibits the reaction [Scopolamine results in increased expression of IL1B protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of IL1B protein]; timosaponin AIII inhibits the reaction [Scopolamine results in increased expression of IL1B protein]
CTD PMID:18357464 PMID:19426756 PMID:21161262 PMID:31077737 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL1RN interleukin 1 receptor antagonist multiple interactions ISO IL1RN protein inhibits the reaction [CSF2 protein results in decreased susceptibility to Scopolamine] CTD PMID:8877002 NCBI chr 2:113,099,365...113,134,016
Ensembl chr 2:113,107,214...113,134,016
JBrowse link
G IL6 interleukin 6 multiple interactions
increases expression
ISO Fatty Acids, Unsaturated deficiency promotes the reaction [Scopolamine results in increased expression of IL6 mRNA]; Scopolamine promotes the reaction [Fatty Acids, Unsaturated deficiency results in increased expression of IL6 mRNA]
acanthoside B inhibits the reaction [Scopolamine results in increased expression of IL6 protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of IL6 protein]
Scopolamine results in increased expression of IL6 mRNA; Scopolamine results in increased expression of IL6 protein
CTD PMID:18357464 PMID:21161262 PMID:31077737 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G ITPR1 inositol 1,4,5-trisphosphate receptor type 1 increases expression ISO Scopolamine results in increased expression of ITPR1 mRNA CTD PMID:12818353 NCBI chr 3:4,493,348...4,847,506
Ensembl chr 3:4,493,345...4,847,840
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression
ISO Physostigmine inhibits the reaction [Scopolamine promotes the reaction [SK&F 82958 results in increased expression of JUN mRNA]]; Scopolamine promotes the reaction [SK&F 82958 results in increased expression of JUN mRNA]
Scopolamine results in decreased expression of JUN protein
Donepezil inhibits the reaction [Scopolamine results in decreased expression of JUN protein]; protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of JUN protein]
CTD PMID:11337201 PMID:29133030 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
JBrowse link
G JUNB JunB proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Scopolamine results in decreased expression of JUNB mRNA CTD PMID:17540011 NCBI chr19:12,791,486...12,793,315
Ensembl chr19:12,791,486...12,793,315
JBrowse link
G KCNA4 potassium voltage-gated channel subfamily A member 4 increases expression ISO Scopolamine results in increased expression of KCNA4 mRNA CTD PMID:12579815 NCBI chr11:30,009,730...30,017,030
Ensembl chr11:30,009,730...30,017,030
JBrowse link
G KCNB1 potassium voltage-gated channel subfamily B member 1 increases expression ISO Scopolamine results in increased expression of KCNB1 mRNA CTD PMID:12579815 PMID:15567561 NCBI chr20:49,363,877...49,484,033
Ensembl chr20:49,293,394...49,484,297
JBrowse link
G KCND2 potassium voltage-gated channel subfamily D member 2 decreases expression ISO Scopolamine results in decreased expression of KCND2 mRNA CTD PMID:12579815 NCBI chr 7:120,273,175...120,750,337
Ensembl chr 7:120,273,175...120,750,337
JBrowse link
G KCNJ3 potassium inwardly rectifying channel subfamily J member 3 multiple interactions EXP Scopolamine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] CTD PMID:18171729 NCBI chr 2:154,698,695...154,858,354
Ensembl chr 2:154,697,855...154,858,354
JBrowse link
G KLF2 Kruppel like factor 2 decreases expression ISO Scopolamine results in decreased expression of KLF2 mRNA CTD PMID:17540011 NCBI chr19:16,324,826...16,328,685
Ensembl chr19:16,324,817...16,327,874
Ensembl chr19:16,324,817...16,327,874
JBrowse link
G KLF4 Kruppel like factor 4 decreases expression ISO Scopolamine results in decreased expression of KLF4 mRNA CTD PMID:17540011 NCBI chr 9:107,484,852...107,489,769
Ensembl chr 9:107,484,852...107,490,482
JBrowse link
G LNPEP leucyl and cystinyl aminopeptidase multiple interactions EXP [AGT protein modified form binds to and results in decreased activity of LNPEP protein] which results in decreased susceptibility to Scopolamine CTD PMID:11707427 NCBI chr 5:96,934,859...97,037,513
Ensembl chr 5:96,935,394...97,037,513
JBrowse link
G MADD MAP kinase activating death domain increases expression ISO Scopolamine results in increased expression of MADD mRNA CTD PMID:12818353 NCBI chr11:47,269,188...47,330,031
Ensembl chr11:47,269,161...47,330,031
JBrowse link
G MAP2 microtubule associated protein 2 decreases expression
multiple interactions
EXP Scopolamine results in decreased expression of MAP2 protein
Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of MAP2 protein]; withanone inhibits the reaction [Scopolamine results in decreased expression of MAP2 protein]
CTD PMID:22096544 NCBI chr 2:209,424,047...209,734,118
Ensembl chr 2:209,424,058...209,734,118
JBrowse link
G MAPT microtubule associated protein tau decreases expression ISO Scopolamine results in decreased expression of MAPT mRNA CTD PMID:12818353 NCBI chr17:45,894,538...46,028,334
Ensembl chr17:45,894,551...46,028,334
Ensembl chr17:45,894,551...46,028,334
Ensembl chr17:45,894,551...46,028,334
JBrowse link
G MBP myelin basic protein multiple interactions
decreases expression
ISO Melatonin inhibits the reaction [Scopolamine results in decreased expression of MBP protein] CTD PMID:29476728 NCBI chr18:76,978,833...77,133,708
Ensembl chr18:76,978,827...77,133,683
JBrowse link
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming decreases expression ISO Scopolamine results in decreased expression of MUC5AC protein CTD PMID:18357464 PMID:21161262 NCBI chr11:1,157,953...1,201,138
Ensembl chr11:1,157,953...1,201,138
JBrowse link
G NEFH neurofilament heavy chain multiple interactions
decreases expression
EXP Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of NEFH protein]; withanone inhibits the reaction [Scopolamine results in decreased expression of NEFH protein] CTD PMID:22096544 NCBI chr22:29,480,218...29,491,390
Ensembl chr22:29,480,218...29,491,390
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 decreases expression
multiple interactions
ISO Scopolamine results in decreased expression of NFE2L2 protein
7-fluoro-1,3-diphenylisoquinoline-1-amine inhibits the reaction [Scopolamine results in decreased expression of NFE2L2 protein]
CTD PMID:32001261 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NGF nerve growth factor decreases response to substance
multiple interactions
increases response to substance
ISO NGF protein results in decreased susceptibility to Scopolamine
Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NGF mRNA]
NGF protein results in increased susceptibility to Scopolamine
CTD PMID:1661212 PMID:8635431 PMID:16405025 NCBI chr 1:115,285,915...115,338,253
Ensembl chr 1:115,285,917...115,338,256
Ensembl chr 1:115,285,917...115,338,256
Ensembl chr 1:115,285,917...115,338,256
Ensembl chr 1:115,285,917...115,338,256
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions
increases expression
ISO acanthoside B inhibits the reaction [Scopolamine results in increased expression of NOS2 protein]; Serotonin analog inhibits the reaction [Scopolamine results in increased expression of NOS2 protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of NOS2 protein] CTD PMID:26408985 PMID:31077737 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NOVA1 NOVA alternative splicing regulator 1 multiple interactions ISO Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NOVA1 mRNA] CTD PMID:20470870 NCBI chr14:26,443,090...26,598,033
Ensembl chr14:26,443,090...26,598,033
JBrowse link
G NOVA2 NOVA alternative splicing regulator 2 multiple interactions ISO Scopolamine inhibits the reaction [Pilocarpine results in decreased expression of NOVA2 mRNA] CTD PMID:20470870 NCBI chr19:45,933,734...45,973,865
Ensembl chr19:45,933,734...45,974,044
Ensembl chr19:45,933,734...45,974,044
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions
decreases expression
ISO Serotonin analog inhibits the reaction [Scopolamine results in decreased expression of NQO1 protein] CTD PMID:26408985 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G NQO2 N-ribosyldihydronicotinamide:quinone reductase 2 increases expression ISO Scopolamine results in increased expression of NQO2 mRNA CTD PMID:20861374 NCBI chr 6:2,999,894...3,019,755
Ensembl chr 6:2,987,987...3,021,850
Ensembl chr 6:2,987,987...3,021,850
Ensembl chr 6:2,987,987...3,021,850
JBrowse link
G NR1D1 nuclear receptor subfamily 1 group D member 1 decreases expression ISO Scopolamine results in decreased expression of NR1D1 mRNA CTD PMID:17540011 NCBI chr17:40,092,793...40,100,589
Ensembl chr17:40,092,793...40,100,589
JBrowse link
G NR4A1 nuclear receptor subfamily 4 group A member 1 decreases expression ISO Scopolamine results in decreased expression of NR4A1 mRNA CTD PMID:17540011 NCBI chr12:52,022,832...52,059,507
Ensembl chr12:52,022,832...52,059,507
JBrowse link
G NTF3 neurotrophin 3 multiple interactions ISO Scopolamine inhibits the reaction [Pilocarpine results in decreased expression of NTF3 mRNA] CTD PMID:8635431 NCBI chr12:5,432,108...5,495,299
Ensembl chr12:5,432,108...5,521,536
JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 multiple interactions
decreases expression
ISO Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NTRK2 mRNA]
Scopolamine results in decreased expression of NTRK2 protein
[acanthoside B co-treated with Scopolamine] results in increased phosphorylation of NTRK2 protein; [Tacrine co-treated with Scopolamine] results in increased phosphorylation of NTRK2 protein; Melatonin inhibits the reaction [Scopolamine results in decreased expression of NTRK2 protein]
CTD PMID:8635431 PMID:29476728 PMID:31077737 NCBI chr 9:84,668,458...85,027,070
Ensembl chr 9:84,668,551...85,027,070
Ensembl chr 9:84,668,551...85,027,070
JBrowse link
G NTRK3 neurotrophic receptor tyrosine kinase 3 multiple interactions ISO Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NTRK3 mRNA] CTD PMID:8635431 NCBI chr15:87,859,749...88,256,796
Ensembl chr15:87,859,751...88,256,768
JBrowse link
G PDCD4 programmed cell death 4 increases expression ISO Scopolamine results in increased expression of PDCD4 mRNA CTD PMID:12818353 NCBI chr10:110,871,928...110,900,006
Ensembl chr10:110,871,795...110,900,006
JBrowse link
G PDYN prodynorphin decreases response to substance
multiple interactions
increases expression
ISO PDYN protein modified form results in decreased susceptibility to Scopolamine
MR 2266 inhibits the reaction [PDYN protein modified form results in decreased susceptibility to Scopolamine]
Scopolamine results in increased expression of PDYN mRNA
CTD PMID:7768285 PMID:17540011 NCBI chr20:1,978,756...1,994,285
Ensembl chr20:1,978,757...1,994,285
JBrowse link
G PENK proenkephalin multiple interactions ISO Scopolamine inhibits the reaction [Haloperidol results in increased expression of PENK mRNA] CTD PMID:7637876 NCBI chr 8:56,440,957...56,446,641
Ensembl chr 8:56,436,674...56,446,671
JBrowse link
G PGAM1 phosphoglycerate mutase 1 decreases expression ISO Scopolamine results in decreased expression of PGAM1 mRNA CTD PMID:12818353 NCBI chr10:97,426,191...97,433,444
Ensembl chr10:97,426,191...97,433,444
JBrowse link
G PREP prolyl endopeptidase increases response to substance
increases expression
multiple interactions
ISO PREP protein results in increased susceptibility to Scopolamine
Scopolamine results in increased expression of PREP protein
Piracetam inhibits the reaction [Scopolamine results in increased expression of PREP protein]
CTD PMID:17244263 PMID:18318186 NCBI chr 6:105,273,218...105,403,102
Ensembl chr 6:105,273,218...105,454,062
Ensembl chr 6:105,273,218...105,454,062
JBrowse link
G PRKRA protein activator of interferon induced protein kinase EIF2AK2 decreases expression ISO Scopolamine results in decreased expression of PRKRA mRNA CTD PMID:12818353 NCBI chr 2:178,431,414...178,451,175
Ensembl chr 2:178,431,414...178,451,512
Ensembl chr 2:178,431,414...178,451,512
JBrowse link
G PSEN2 presenilin 2 decreases expression ISO Scopolamine results in decreased expression of PSEN2 mRNA CTD PMID:12818353 NCBI chr 1:226,870,594...226,903,829
Ensembl chr 1:226,870,184...226,896,105
Ensembl chr 1:226,870,184...226,896,105
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO Scopolamine results in increased expression of PTGS2 protein
acanthoside B inhibits the reaction [Scopolamine results in increased expression of PTGS2 protein]; Serotonin analog inhibits the reaction [Scopolamine results in increased expression of PTGS2 protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of PTGS2 protein]
CTD PMID:26408985 PMID:31077737 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G RAB14 RAB14, member RAS oncogene family increases expression ISO Scopolamine results in increased expression of RAB14 mRNA CTD PMID:17540011 NCBI chr 9:121,178,133...121,201,869
Ensembl chr 9:121,178,133...121,223,014
JBrowse link
G RAPGEF3 Rap guanine nucleotide exchange factor 3 decreases expression ISO Scopolamine results in decreased expression of RAPGEF3 mRNA CTD PMID:12818353 NCBI chr12:47,734,363...47,758,880
Ensembl chr12:47,734,363...47,771,040
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO mangiferin inhibits the reaction [Scopolamine results in increased phosphorylation of and results in increased activity of RELA protein]; Scopolamine results in increased phosphorylation of and results in increased activity of RELA protein; timosaponin AIII inhibits the reaction [Scopolamine results in increased phosphorylation of and results in increased activity of RELA protein] CTD PMID:19182383 PMID:19426756 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G REM2 RRAD and GEM like GTPase 2 decreases expression ISO Scopolamine results in decreased expression of REM2 mRNA CTD PMID:17540011 NCBI chr14:22,883,165...22,887,678
Ensembl chr14:22,883,222...22,887,678
JBrowse link
G RGS7BP regulator of G protein signaling 7 binding protein decreases expression ISO Scopolamine results in decreased expression of RGS7BP mRNA CTD PMID:17540011 NCBI chr 5:64,505,947...64,612,330
Ensembl chr 5:64,506,015...64,612,319
JBrowse link
G ROBO3 roundabout guidance receptor 3 decreases expression ISO Scopolamine results in decreased expression of ROBO3 mRNA CTD PMID:17540011 NCBI chr11:124,865,432...124,881,471
Ensembl chr11:124,865,432...124,881,471
JBrowse link
G RRAGA Ras related GTP binding A increases expression ISO Scopolamine results in increased expression of RRAGA mRNA CTD PMID:12818353 NCBI chr 9:19,049,427...19,051,025
Ensembl chr 9:19,049,427...19,051,025
JBrowse link
G S100A4 S100 calcium binding protein A4 decreases expression ISO Scopolamine results in decreased expression of S100A4 mRNA CTD PMID:17540011 NCBI chr 1:153,543,621...153,545,806
Ensembl chr 1:153,543,613...153,550,136
JBrowse link
G S1PR1 sphingosine-1-phosphate receptor 1 increases expression ISO Scopolamine results in increased expression of S1PR1 mRNA CTD PMID:12818353 NCBI chr 1:101,236,899...101,241,518
Ensembl chr 1:101,236,865...101,243,713
JBrowse link
G SCAMP2 secretory carrier membrane protein 2 increases expression ISO Scopolamine results in increased expression of SCAMP2 mRNA CTD PMID:12818353 NCBI chr15:74,843,730...74,873,365
Ensembl chr15:74,843,730...74,873,365
JBrowse link
G SIGMAR1 sigma non-opioid intracellular receptor 1 multiple interactions ISO [2-(4-morpholino)ethyl-1-phenylcyclohexane-1-carboxylate binds to and results in increased activity of SIGMAR1 protein] which results in decreased susceptibility to Scopolamine; [igmesine binds to and results in increased activity of SIGMAR1 protein] which results in decreased susceptibility to Scopolamine CTD PMID:12028363 NCBI chr 9:34,634,722...34,637,787
Ensembl chr 9:34,634,722...34,637,809
Ensembl chr 9:34,634,722...34,637,809
JBrowse link
G SLC47A1 solute carrier family 47 member 1 multiple interactions EXP Scopolamine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr17:19,533,854...19,579,034
Ensembl chr17:19,495,385...19,579,034
JBrowse link
G SLC47A2 solute carrier family 47 member 2 multiple interactions EXP Scopolamine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr17:19,678,313...19,719,598
Ensembl chr17:19,678,288...19,718,979
JBrowse link
G SULT1A1 sulfotransferase family 1A member 1 increases expression ISO Scopolamine results in increased expression of SULT1A1 mRNA CTD PMID:17540011 NCBI chr16:28,605,587...28,623,395
Ensembl chr16:28,605,196...28,623,625
Ensembl chr16:28,605,196...28,623,625
JBrowse link
G SYP synaptophysin multiple interactions
increases expression
ISO cyclo-L-glycyl-L-2-allylproline inhibits the reaction [Scopolamine results in increased expression of SYP protein] CTD PMID:20188767 NCBI chr  X:49,187,815...49,200,193
Ensembl chr  X:49,187,815...49,200,199
Ensembl chr  X:49,187,815...49,200,199
JBrowse link
G TAC1 tachykinin precursor 1 decreases response to substance ISO TAC1 protein modified form results in decreased susceptibility to Scopolamine CTD PMID:20600432 NCBI chr 7:97,732,086...97,740,472
Ensembl chr 7:97,732,084...97,740,472
JBrowse link
G TNF tumor necrosis factor multiple interactions
increases expression
ISO acanthoside B inhibits the reaction [Scopolamine results in increased expression of TNF protein]; mangiferin inhibits the reaction [Scopolamine results in increased expression of TNF protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of TNF protein]; timosaponin AIII inhibits the reaction [Scopolamine results in increased expression of TNF protein]
Scopolamine results in increased expression of TNF mRNA
Scopolamine results in increased expression of TNF mRNA; Scopolamine results in increased expression of TNF protein
CTD PMID:18357464 PMID:19182383 PMID:19426756 PMID:21161262 PMID:31077737 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNRC6A trinucleotide repeat containing adaptor 6A decreases expression ISO Scopolamine results in decreased expression of TNRC6A mRNA CTD PMID:17540011 NCBI chr16:24,610,205...24,826,223
Ensembl chr16:24,610,209...24,827,632
JBrowse link
G TPD52L1 TPD52 like 1 increases expression ISO Scopolamine results in increased expression of TPD52L1 mRNA CTD PMID:17540011 NCBI chr 6:125,153,730...125,264,407
Ensembl chr 6:125,119,049...125,264,407
JBrowse link
G VGF VGF nerve growth factor inducible decreases expression ISO Scopolamine results in decreased expression of VGF mRNA CTD PMID:17540011 NCBI chr 7:101,162,509...101,169,956
Ensembl chr 7:101,162,509...101,165,569
JBrowse link
G VIP vasoactive intestinal peptide decreases response to substance ISO VIP protein results in decreased susceptibility to Scopolamine CTD PMID:8208360 NCBI chr 6:152,750,797...152,759,765
Ensembl chr 6:152,750,797...152,759,765
JBrowse link
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
EXP Atropine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Atropine results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 2:168,915,468...169,031,396
Ensembl chr 2:168,915,498...169,031,324
JBrowse link
G ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions EXP [Parathion co-treated with Atropine] results in increased expression of ABL1 mRNA CTD PMID:17390078 NCBI chr 9:130,713,043...130,887,675
Ensembl chr 9:130,713,016...130,887,675
JBrowse link
G ACHE acetylcholinesterase (Cartwright blood group) multiple interactions EXP
ISO
Atropine inhibits the reaction [[Organophosphorus Compounds results in decreased activity of ACHE protein] which results in increased abundance of Acetylcholine]; Atropine inhibits the reaction [Carbachol results in increased metabolism of and results in increased secretion of ACHE protein]; Atropine inhibits the reaction [Paraoxon results in increased expression of ACHE protein]
[Atropine co-treated with Obidoxime Chloride] inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of ACHE protein; [Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein; [pralidoxime co-treated with Atropine] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; [tariquidar co-treated with asoxime chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; Atropine inhibits the reaction [Methyl Parathion results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [[Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [[Atropine co-treated with Curcumin] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]]
[1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [[1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide co-treated with cucurbit(7)uril] co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; Atropine inhibits the reaction [Sarin results in decreased activity of ACHE protein]; Atropine promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; Atropine promotes the reaction [haloxon results in increased phosphorylation of ACHE protein]; Atropine promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein]
CTD PMID:2241428 PMID:10421444 PMID:17963125 PMID:20105433 PMID:21600273 PMID:21787676 PMID:22783142 PMID:23047022 PMID:24881594 PMID:26751814 PMID:31794810 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G ADCY5 adenylate cyclase 5 increases response to substance ISO ADCY5 protein results in increased susceptibility to Atropine CTD PMID:12869393 NCBI chr 3:123,282,296...123,449,090
Ensembl chr 3:123,282,296...123,449,090
Ensembl chr 3:123,282,296...123,449,090
JBrowse link
G AQP5 aquaporin 5 multiple interactions ISO Atropine inhibits the reaction [Pilocarpine affects the localization of AQP5 protein] CTD PMID:26208470 NCBI chr12:49,961,855...49,965,682
Ensembl chr12:49,961,872...49,965,682
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the expression of BAX mRNA] CTD PMID:21971501 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCAR1 BCAR1 scaffold protein, Cas family member multiple interactions EXP Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]] CTD PMID:10537051 NCBI chr16:75,228,181...75,268,007
Ensembl chr16:75,228,181...75,268,053
JBrowse link
G BCHE butyrylcholinesterase multiple interactions ISO
EXP
[Atropine co-treated with pralidoxime] results in decreased expression of BCHE protein; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of BCHE protein
[BCHE protein co-treated with asoxime chloride co-treated with pro-diazepam co-treated with Atropine] results in decreased susceptibility to VX
CTD PMID:17963125 PMID:22981459 NCBI chr 3:165,772,904...165,837,423
Ensembl chr 3:165,772,904...165,837,462
JBrowse link
G BDKRB2 bradykinin receptor B2 multiple interactions ISO BDKRB2 affects the susceptibility to [Propranolol co-treated with Atropine] CTD PMID:10614985 NCBI chr14:96,204,839...96,244,164
Ensembl chr14:96,204,679...96,244,166
JBrowse link
G BMP6 bone morphogenetic protein 6 multiple interactions ISO Atropine inhibits the reaction [Carbon Tetrachloride results in increased expression of BMP6 mRNA] CTD PMID:18472332 NCBI chr 6:7,726,099...7,881,728
Ensembl chr 6:7,726,099...7,881,728
JBrowse link
G CACNA1E calcium voltage-gated channel subunit alpha1 E multiple interactions ISO Atropine inhibits the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]] CTD PMID:12663092 NCBI chr 1:181,317,712...181,808,084
Ensembl chr 1:181,317,690...181,808,084
JBrowse link
G CALCA calcitonin related polypeptide alpha affects activity ISO Atropine affects the activity of CALCA protein CTD PMID:7906887 PMID:10075105 NCBI chr11:14,966,668...14,972,361
Ensembl chr11:14,966,668...14,972,354
Ensembl chr11:14,966,668...14,972,354
JBrowse link
G CASP3 caspase 3 increases expression ISO Atropine results in increased expression of CASP3 mRNA CTD PMID:19815060 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CCL5 C-C motif chemokine ligand 5 multiple interactions ISO [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 protein] CTD PMID:22245128 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793
JBrowse link
G CCNA1 cyclin A1 multiple interactions
increases expression
EXP [Parathion co-treated with Atropine] results in increased expression of CCNA1 mRNA
Atropine results in increased expression of CCNA1 mRNA
CTD PMID:17390078 NCBI chr13:36,430,488...36,442,870
Ensembl chr13:36,431,520...36,442,870
JBrowse link
G CCND3 cyclin D3 multiple interactions EXP [Parathion co-treated with Atropine] results in increased expression of CCND3 mRNA CTD PMID:17390078 NCBI chr 6:41,934,933...42,048,894
Ensembl chr 6:41,934,933...42,050,357
Ensembl chr 6:41,934,933...42,050,357
JBrowse link
G CCNE1 cyclin E1 multiple interactions
increases expression
EXP [Parathion co-treated with Atropine] results in increased expression of CCNE1 mRNA
Atropine results in increased expression of CCNE1 mRNA
CTD PMID:17390078 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312
JBrowse link
G CCNE2 cyclin E2 increases expression
multiple interactions
EXP Atropine results in increased expression of CCNE2 mRNA
[Parathion co-treated with Atropine] results in increased expression of CCNE2 mRNA
CTD PMID:17390078 NCBI chr 8:94,880,224...94,896,671
Ensembl chr 8:94,879,770...94,896,678
JBrowse link
G CD40 CD40 molecule multiple interactions EXP Atropine inhibits the reaction [Carbachol results in increased expression of CD40 protein] CTD PMID:16879495 NCBI chr20:46,118,242...46,129,858
Ensembl chr20:46,118,278...46,129,863
JBrowse link
G CDC20 cell division cycle 20 increases expression
multiple interactions
EXP Atropine results in increased expression of CDC20 mRNA
[Parathion co-treated with Atropine] results in increased expression of CDC20 mRNA
CTD PMID:17390078 NCBI chr 1:43,358,981...43,363,203
Ensembl chr 1:43,358,981...43,363,203
JBrowse link
G CDC6 cell division cycle 6 multiple interactions EXP [Parathion co-treated with Atropine] results in increased expression of CDC6 mRNA CTD PMID:17390078 NCBI chr17:40,287,878...40,304,657
Ensembl chr17:40,287,879...40,304,657
JBrowse link
G CDK1 cyclin dependent kinase 1 increases expression
multiple interactions
EXP Atropine results in increased expression of CDK1 mRNA
[Parathion co-treated with Atropine] results in increased expression of CDK1 mRNA
CTD PMID:17390078 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852
JBrowse link
G CES1 carboxylesterase 1 multiple interactions EXP Atropine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate] CTD PMID:9311626 NCBI chr16:55,802,851...55,833,127
Ensembl chr16:55,802,851...55,833,337
JBrowse link
G CHRM1 cholinergic receptor muscarinic 1 multiple interactions
decreases activity
ISO
EXP
Atropine binds to and results in decreased activity of CHRM1 protein; Atropine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]
Atropine results in decreased activity of CHRM1 protein
Atropine affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]
CTD PMID:16439611 PMID:18316702 PMID:31830555 NCBI chr11:62,908,675...62,921,861
Ensembl chr11:62,908,679...62,921,807
JBrowse link
G CHRM2 cholinergic receptor muscarinic 2 multiple interactions EXP Atropine binds to and results in decreased activity of CHRM2 protein CTD PMID:15140916 NCBI chr 7:136,868,652...137,020,213
Ensembl chr 7:136,868,669...137,020,255
Ensembl chr 7:136,868,669...137,020,255
JBrowse link
G CHRM3 cholinergic receptor muscarinic 3 multiple interactions
decreases activity
EXP Atropine binds to and results in decreased activity of CHRM3 protein; Atropine inhibits the reaction [Carbachol results in increased activity of CHRM3 protein]
Atropine results in decreased activity of CHRM3 protein
CTD PMID:15140916 PMID:20708676 PMID:31830555 NCBI chr 1:239,386,565...239,915,450
Ensembl chr 1:239,386,565...239,915,452
JBrowse link
G CHRM4 cholinergic receptor muscarinic 4 affects binding
multiple interactions
EXP Atropine binds to CHRM4 protein
[WIN 62577 co-treated with Quinuclidinyl Benzilate] inhibits the reaction [Atropine binds to CHRM4 protein]
CTD PMID:16709648 NCBI chr11:46,383,789...46,391,776
Ensembl chr11:46,385,098...46,386,608
JBrowse link
G CHRM5 cholinergic receptor muscarinic 5 multiple interactions EXP Atropine inhibits the reaction [Acetylcholine results in increased activity of CHRM5 protein] CTD PMID:31323226 NCBI chr15:33,968,497...34,067,458
Ensembl chr15:33,968,497...34,067,458
Ensembl chr15:33,968,497...34,067,458
JBrowse link
G CHRNA4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions
affects binding
EXP
ISO
Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
Atropine binds to [CHRNA4 protein binds to CHRNB2 protein]
Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 protein]]
CTD PMID:15733544 PMID:21791372 NCBI chr20:63,343,223...63,375,471
Ensembl chr20:63,343,223...63,378,401
JBrowse link
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit affects binding
multiple interactions
EXP
ISO
Atropine binds to [CHRNA4 protein binds to CHRNB2 protein]
Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 protein]]
Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
CTD PMID:15733544 PMID:21791372 NCBI chr 1:154,567,778...154,584,708
Ensembl chr 1:154,567,778...154,580,013
JBrowse link
G CREB1 cAMP responsive element binding protein 1 multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of CREB1 protein] CTD PMID:21971501 NCBI chr 2:207,529,943...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G CRH corticotropin releasing hormone multiple interactions EXP
ISO
[Atropine co-treated with SR 140333 co-treated with SR 48968] results in decreased activity of CRH protein
Atropine inhibits the reaction [acephate results in increased expression of CRH mRNA]; Atropine inhibits the reaction [acephate results in increased secretion of CRH protein]; Atropine inhibits the reaction [methamidophos results in increased expression of CRH mRNA]; Atropine inhibits the reaction [methamidophos results in increased secretion of CRH protein]
CTD PMID:12039681 PMID:12906840 NCBI chr 8:66,176,376...66,178,464
Ensembl chr 8:66,176,376...66,178,464
JBrowse link
G CTNNB1 catenin beta 1 multiple interactions EXP Atropine inhibits the reaction [Parathion results in increased expression of CTNNB1 protein mutant form]; Atropine inhibits the reaction [Parathion results in increased expression of CTNNB1 protein] CTD PMID:17390078 NCBI chr 3:41,199,422...41,240,445
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 multiple interactions ISO [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 protein] CTD PMID:22245128 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308
JBrowse link
G DVL2 dishevelled segment polarity protein 2 multiple interactions EXP Atropine inhibits the reaction [Parathion results in increased expression of DVL2 protein] CTD PMID:17390078 NCBI chr17:7,225,341...7,234,544
Ensembl chr17:7,225,342...7,234,517
JBrowse link
G EDN1 endothelin 1 multiple interactions EXP EDN1 protein results in decreased activity of [Atropine co-treated with Histamine] CTD PMID:12906840 NCBI chr 6:12,256,463...12,297,194
Ensembl chr 6:12,290,361...12,297,194
JBrowse link
G EGFR epidermal growth factor receptor multiple interactions EXP Atropine inhibits the reaction [Parathion results in increased expression of EGFR protein] CTD PMID:17390078 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G EGR1 early growth response 1 multiple interactions ISO Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR1 mRNA] CTD PMID:7968354 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
JBrowse link
G EGR2 early growth response 2 multiple interactions ISO Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA] CTD PMID:7968354 NCBI chr10:62,811,996...62,819,167
Ensembl chr10:62,811,996...62,919,900
JBrowse link
G EZR ezrin multiple interactions EXP Atropine inhibits the reaction [Parathion results in increased expression of EZR protein] CTD PMID:17390078 NCBI chr 6:158,765,744...158,819,368
Ensembl chr 6:158,765,741...158,819,368
JBrowse link
G F2 coagulation factor II, thrombin multiple interactions ISO [Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in decreased expression of F2 mRNA; [Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in increased activity of F2 protein CTD PMID:30515700 NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506
Ensembl chr11:46,719,196...46,739,506
JBrowse link
G F2R coagulation factor II thrombin receptor multiple interactions ISO [Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in increased expression of F2R protein CTD PMID:30515700 NCBI chr 5:76,716,126...76,735,770
Ensembl chr 5:76,716,126...76,735,770
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO
EXP
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased expression of FOS protein]; Atropine inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]
Atropine inhibits the reaction [Paraoxon results in increased expression of FOS mRNA]
Atropine results in increased expression of FOS protein
CTD PMID:7968354 PMID:8281324 PMID:21787676 PMID:21971501 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G GHRL ghrelin and obestatin prepropeptide multiple interactions ISO Atropine inhibits the reaction [[Pentobarbital co-treated with L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide] results in increased expression of GHRL protein] CTD PMID:16959836 NCBI chr 3:10,285,666...10,292,947
Ensembl chr 3:10,285,666...10,292,947
JBrowse link
G GLRA1 glycine receptor alpha 1 multiple interactions EXP Atropine binds to and results in decreased activity of GLRA1 protein CTD PMID:15081878 NCBI chr 5:151,822,513...151,924,851
Ensembl chr 5:151,822,513...151,924,842
Ensembl chr 5:151,822,513...151,924,842
JBrowse link
G GRM4 glutamate metabotropic receptor 4 multiple interactions EXP Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] CTD PMID:18171729 NCBI chr 6:34,018,643...34,155,622
Ensembl chr 6:34,018,643...34,155,622
Ensembl chr 6:34,018,643...34,155,622
JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions ISO [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of ICAM1 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of ICAM1 protein] CTD PMID:22245128 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of IL1B mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of IL1B protein] CTD PMID:22245128 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 multiple interactions ISO [Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 mRNA]; [Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 protein] CTD PMID:22245128 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of JUN protein] CTD PMID:21971501 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
JBrowse link
G JUNB JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Atropine inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA] CTD PMID:7968354 NCBI chr19:12,791,486...12,793,315
Ensembl chr19:12,791,486...12,793,315
JBrowse link
G KCNJ3 potassium inwardly rectifying channel subfamily J member 3 multiple interactions EXP Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] CTD PMID:18171729 NCBI chr 2:154,698,695...154,858,354
Ensembl chr 2:154,697,855...154,858,354
JBrowse link
G KIT KIT proto-oncogene, receptor tyrosine kinase multiple interactions EXP Atropine inhibits the reaction [Parathion results in increased expression of KIT protein] CTD PMID:17390078 NCBI chr 4:54,657,957...54,740,715
Ensembl chr 4:54,657,918...54,740,715
JBrowse link
G LTF lactotransferrin multiple interactions EXP Atropine inhibits the reaction [methylcholine results in increased secretion of LTF protein] CTD PMID:11112886 NCBI chr 3:46,435,645...46,485,234
Ensembl chr 3:46,435,645...46,485,234
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK1 protein] CTD PMID:21971501 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK14 mitogen-activated protein kinase 14 multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK14 protein] CTD PMID:21971501 NCBI chr 6:36,027,711...36,122,964
Ensembl chr 6:36,027,677...36,111,236
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK3 protein] CTD PMID:21971501 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK8 protein] CTD PMID:21971501 NCBI chr10:48,306,673...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MCM4 minichromosome maintenance complex component 4 multiple interactions
increases expression
EXP [Parathion co-treated with Atropine] results in increased expression of MCM4 mRNA
Atropine results in increased expression of MCM4 mRNA
CTD PMID:17390078 NCBI chr 8:47,960,941...47,978,160
Ensembl chr 8:47,960,185...47,978,160
JBrowse link
G MCM6 minichromosome maintenance complex component 6 increases expression
multiple interactions
EXP Atropine results in increased expression of MCM6 mRNA
[Parathion co-treated with Atropine] results in increased expression of MCM6 mRNA
CTD PMID:17390078 NCBI chr 2:135,839,626...135,876,443
Ensembl chr 2:135,839,626...135,876,443
JBrowse link
G NEFH neurofilament heavy chain affects expression ISO Atropine affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr22:29,480,218...29,491,390
Ensembl chr22:29,480,218...29,491,390
JBrowse link
G NLRP3 NLR family pyrin domain containing 3 increases expression EXP Atropine results in increased expression of NLRP3 mRNA CTD PMID:28138970 NCBI chr 1:247,416,163...247,448,823
Ensembl chr 1:247,416,156...247,449,108
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO Atropine inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; Atropine inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA] CTD PMID:15610444 PMID:16944022 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NOTCH4 notch receptor 4 multiple interactions EXP Atropine inhibits the reaction [Parathion results in increased expression of NOTCH4 protein] CTD PMID:17390078 NCBI chr 6:32,194,843...32,224,067
Ensembl chr 6:32,194,843...32,224,067
JBrowse link
G NPPA natriuretic peptide A affects activity ISO Atropine affects the activity of NPPA protein modified form CTD PMID:1363893 NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345
JBrowse link
G OPRL1 opioid related nociceptin receptor 1 multiple interactions ISO Atropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein] CTD PMID:12007927 NCBI chr20:64,080,082...64,100,643
Ensembl chr20:64,080,082...64,100,643
JBrowse link
G PCNA proliferating cell nuclear antigen multiple interactions EXP Atropine inhibits the reaction [Malathion results in increased expression of PCNA]; Atropine inhibits the reaction [Parathion results in increased expression of PCNA] CTD PMID:12762645 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
JBrowse link
G PNOC prepronociceptin multiple interactions ISO Atropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein] CTD PMID:12007927 NCBI chr 8:28,316,979...28,343,355
Ensembl chr 8:28,316,986...28,343,355
JBrowse link
G POMC proopiomelanocortin multiple interactions ISO Atropine inhibits the reaction [Acetylcholine results in increased expression of POMC protein] CTD PMID:7588217 NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions ISO [Atropine co-treated with Glucose] binds to PPARA protein; Atropine inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]] CTD PMID:18812576 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Atropine affects the reaction [Indomethacin results in increased expression of PTGS2]; Atropine inhibits the reaction [Indomethacin results in increased expression of PTGS2 mRNA]; Atropine inhibits the reaction [Indomethacin results in increased expression of PTGS2]; Atropine inhibits the reaction [SC 560 results in increased expression of PTGS2 mRNA] CTD PMID:15104355 PMID:15610444 PMID:16259740 PMID:16804302 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G PTK2 protein tyrosine kinase 2 multiple interactions EXP Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein]] CTD PMID:10537051 NCBI chr 8:140,657,900...141,002,079
Ensembl chr 8:140,657,900...141,002,216
JBrowse link
G PXN paxillin multiple interactions EXP Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]] CTD PMID:10537051 NCBI chr12:120,210,447...120,265,737
Ensembl chr12:120,210,439...120,265,771
JBrowse link
G RAC3 Rac family small GTPase 3 multiple interactions EXP Atropine inhibits the reaction [Parathion results in increased expression of RAC3 protein] CTD PMID:17390078 NCBI chr17:82,031,678...82,034,204
Ensembl chr17:82,031,678...82,034,204
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of RELA protein] CTD PMID:21971501 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G RHOA ras homolog family member A multiple interactions EXP Atropine inhibits the reaction [Parathion results in increased expression of RHOA protein] CTD PMID:17390078 NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,145...49,412,998
Ensembl chr 3:49,359,145...49,412,998
JBrowse link
G SLC22A1 solute carrier family 22 member 1 multiple interactions EXP Atropine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Atropine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:16263091 PMID:21641380 NCBI chr 6:160,121,808...160,160,590
Ensembl chr 6:160,121,815...160,158,718
JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP Atropine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Atropine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Atropine inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium] CTD PMID:16263091 PMID:21599003 PMID:23770354 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638
JBrowse link
G SLC22A3 solute carrier family 22 member 3 multiple interactions
increases uptake
EXP Atropine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]
SLC22A3 protein results in increased uptake of Atropine
CTD PMID:16263091 NCBI chr 6:160,348,378...160,454,982
Ensembl chr 6:160,348,378...160,452,577
JBrowse link
G SLC22A4 solute carrier family 22 member 4 multiple interactions EXP Atropine inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium] CTD PMID:21641380 NCBI chr 5:132,294,384...132,344,199
Ensembl chr 5:132,294,394...132,344,190
JBrowse link
G SLC47A1 solute carrier family 47 member 1 multiple interactions EXP Atropine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr17:19,533,854...19,579,034
Ensembl chr17:19,495,385...19,579,034
JBrowse link
G SLC47A2 solute carrier family 47 member 2 multiple interactions EXP Atropine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr17:19,678,313...19,719,598
Ensembl chr17:19,678,288...19,718,979
JBrowse link
G SLPI secretory leukocyte peptidase inhibitor increases expression EXP Atropine results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr20:45,252,239...45,254,564
Ensembl chr20:45,252,239...45,254,564
JBrowse link
G SOCS3 suppressor of cytokine signaling 3 multiple interactions ISO [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of SOCS3 mRNA] CTD PMID:22245128 NCBI chr17:78,356,778...78,360,925
Ensembl chr17:78,356,778...78,360,077
JBrowse link
G SPN sialophorin increases response to substance ISO SPN protein results in increased susceptibility to Atropine CTD PMID:18711009 NCBI chr16:29,662,963...29,670,876
Ensembl chr16:29,662,979...29,670,876
JBrowse link
G TAT tyrosine aminotransferase multiple interactions ISO [Atropine co-treated with Obidoxime Chloride co-treated with Diazepam] inhibits the reaction [Dichlorvos results in increased expression of TAT protein] CTD PMID:7761789 NCBI chr16:71,565,660...71,577,092
Ensembl chr16:71,565,660...71,577,092
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO Atropine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA] CTD PMID:18472332 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of TNF mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of TNF protein] CTD PMID:22245128 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TP53 tumor protein p53 multiple interactions EXP Atropine inhibits the reaction [Malathion results in increased expression of TP53 protein]; Atropine inhibits the reaction [Parathion results in increased expression of TP53 protein] CTD PMID:12762645 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TRIO trio Rho guanine nucleotide exchange factor multiple interactions EXP Atropine inhibits the reaction [Parathion results in increased expression of TRIO protein] CTD PMID:17390078 NCBI chr 5:14,143,342...14,510,204
Ensembl chr 5:14,143,342...14,532,128
JBrowse link
G TRPA1 transient receptor potential cation channel subfamily A member 1 decreases response to substance ISO TRPA1 gene mutant form results in decreased susceptibility to Atropine CTD PMID:29627347 NCBI chr 8:72,021,250...72,094,885
Ensembl chr 8:72,019,917...72,075,584
JBrowse link
G TSHB thyroid stimulating hormone subunit beta multiple interactions ISO [pralidoxime co-treated with Atropine] inhibits the reaction [methamidophos results in decreased expression of TSHB protein] CTD PMID:15891268 NCBI chr 1:115,029,826...115,035,935
Ensembl chr 1:115,029,826...115,034,302
Ensembl chr 1:115,029,826...115,034,302
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions ISO [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of VCAM1 mRNA] CTD PMID:22245128 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24487
    chemical entity 24455
      molecular entity 24418
        polyatomic entity 24346
          heteroatomic molecular entity 23950
            hydroxides 22473
              organic hydroxy compound 20747
                hydroxy carboxylic acid 4260
                  hydroxy monocarboxylic acid 4260
                    3-hydroxy monocarboxylic acid 218
                      (1-hydroxycyclohexyl)acetic acid + 0
                      (2S,3R)-3-hydroxy-2-methylpentanoic acid 0
                      (3R)-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylic acid 0
                      (3S,4S)-3-hydroxy-4-methyldecanoic acid + 0
                      (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoic acid 0
                      (S)-3-hydroxy-2-oxo-3-phenylpropanoic acid 0
                      (S)-3-hydroxydecanoic acid + 0
                      (S)-3-hydroxytetradecanoic acid + 0
                      2-(hydroxymethyl)-4-oxobutanoic acid 0
                      2-ethyl-3-hydroxybutyric acid 0
                      3-hydroxy fatty acid + 0
                      3-hydroxy-2,2-dimethylbutyric acid 0
                      3-hydroxy-2-methylbutanoic acid + 0
                      3-hydroxy-3-methyl-2-oxopentanoic acid + 0
                      3-hydroxy-3-methylhexanoic acid + 0
                      3-hydroxy-5-oxohexanoic acid + 0
                      3-hydroxybut-2-enoic acid + 4
                      3-hydroxybutyric acid + 20
                      3-hydroxydocosanoic acid + 0
                      3-hydroxyhexacosanoic acid + 0
                      3-hydroxyhexanoic acid + 0
                      3-hydroxyisobutyric acid + 0
                      3-hydroxyisovaleric acid + 5
                      3-hydroxyoctadecanoic acid + 0
                      3-hydroxyoctanoic acid + 0
                      3-hydroxypropionic acid + 1
                      3-hydroxypyruvic acid 2
                      3-hydroxytetradecanoic acid + 0
                      agrochelin 0
                      gamma-amino-beta-hydroxybutyric acid + 0
                      mevaldic acid 0
                      mutalomycin 0
                      peramivir 0
                      tropic acid + 195
Path 2
Term Annotations click to browse term
  CHEBI ontology 24487
    subatomic particle 24444
      composite particle 24444
        hadron 24444
          baryon 24444
            nucleon 24444
              atomic nucleus 24444
                atom 24444
                  main group element atom 24301
                    p-block element atom 24301
                      carbon group element atom 24085
                        carbon atom 24046
                          organic molecular entity 24046
                            organic group 22411
                              organic divalent group 22388
                                organodiyl group 22388
                                  carbonyl group 22373
                                    carbonyl compound 22373
                                      carboxylic acid 21372
                                        hydroxy carboxylic acid 4260
                                          hydroxy monocarboxylic acid 4260
                                            3-hydroxy monocarboxylic acid 218
                                              (1-hydroxycyclohexyl)acetic acid + 0
                                              (2S,3R)-3-hydroxy-2-methylpentanoic acid 0
                                              (3R)-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylic acid 0
                                              (3S,4S)-3-hydroxy-4-methyldecanoic acid + 0
                                              (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoic acid 0
                                              (S)-3-hydroxy-2-oxo-3-phenylpropanoic acid 0
                                              (S)-3-hydroxydecanoic acid + 0
                                              (S)-3-hydroxytetradecanoic acid + 0
                                              2-(hydroxymethyl)-4-oxobutanoic acid 0
                                              2-ethyl-3-hydroxybutyric acid 0
                                              3-hydroxy fatty acid + 0
                                              3-hydroxy-2,2-dimethylbutyric acid 0
                                              3-hydroxy-2-methylbutanoic acid + 0
                                              3-hydroxy-3-methyl-2-oxopentanoic acid + 0
                                              3-hydroxy-3-methylhexanoic acid + 0
                                              3-hydroxy-5-oxohexanoic acid + 0
                                              3-hydroxybut-2-enoic acid + 4
                                              3-hydroxybutyric acid + 20
                                              3-hydroxydocosanoic acid + 0
                                              3-hydroxyhexacosanoic acid + 0
                                              3-hydroxyhexanoic acid + 0
                                              3-hydroxyisobutyric acid + 0
                                              3-hydroxyisovaleric acid + 5
                                              3-hydroxyoctadecanoic acid + 0
                                              3-hydroxyoctanoic acid + 0
                                              3-hydroxypropionic acid + 1
                                              3-hydroxypyruvic acid 2
                                              3-hydroxytetradecanoic acid + 0
                                              agrochelin 0
                                              gamma-amino-beta-hydroxybutyric acid + 0
                                              mevaldic acid 0
                                              mutalomycin 0
                                              peramivir 0
                                              tropic acid + 195
paths to the root