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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:zomepirac
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Accession:CHEBI:35859 term browser browse the term
Definition:A pyrrole that has formula C15H14ClNO3.
Synonyms:exact_synonym: [5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-yl]acetic acid
 related_synonym: 5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrole-2-acetic acid;   Formula=C15H14ClNO3;   InChI=1S/C15H14ClNO3/c1-9-7-12(8-13(18)19)17(2)14(9)15(20)10-3-5-11(16)6-4-10/h3-7H,8H2,1-2H3,(H,18,19);   InChIKey=ZXVNMYWKKDOREA-UHFFFAOYSA-N;   SMILES=Cc1cc(CC(O)=O)n(C)c1C(=O)c1ccc(Cl)cc1
 xref: Beilstein:487946;   CAS:33369-31-2;   DrugBank:DB04828;   Drug_Central:2871;   LINCS:LSM-6673
 xref_mesh: MESH:C020549
 xref: Wikipedia:Zomepirac


show annotations for term's descendants           Sort by:
 
zomepirac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO zomepirac results in decreased activity of AKR1C2 protein CTD PMID:19010312 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO zomepirac results in decreased activity of AKR1C3 protein CTD PMID:19010312 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Alb albumin affects binding ISO zomepirac binds to ALB protein CTD PMID:6627828, PMID:8027947 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Dhrs11 dehydrogenase/reductase 11 decreases activity ISO zomepirac results in decreased activity of DHRS11 protein CTD PMID:30926317 NCBI chr10:72,144,042...72,153,496
Ensembl chr10:72,144,042...72,153,375
JBrowse link
G Glo1 glyoxalase 1 decreases activity ISO zomepirac results in decreased activity of GLO1 protein CTD PMID:17243824 NCBI chr20:9,273,589...9,291,608
Ensembl chr20:9,273,594...9,291,610
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO [zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of ICAM1 mRNA CTD PMID:29154782 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il1a interleukin 1 alpha multiple interactions
increases expression
ISO [zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of IL1A mRNA; LY6G protein affects the reaction [[zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of IL1A mRNA]
zomepirac metabolite results in increased expression of IL1A
CTD PMID:29154782 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il6 interleukin 6 increases expression ISO zomepirac metabolite results in increased expression of IL6 CTD PMID:29154782 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Lcn2 lipocalin 2 multiple interactions ISO [zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of LCN2 mRNA; LY6G protein affects the reaction [[zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of LCN2 mRNA] CTD PMID:29154782 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
G Ptgdr2 prostaglandin D2 receptor 2 multiple interactions
affects binding
ISO zomepirac inhibits the reaction [Prostaglandin D2 binds to PTGDR2 protein]
zomepirac binds to PTGDR2 protein
CTD PMID:15563582 NCBI chr 1:226,976,455...226,995,641
Ensembl chr 1:226,993,250...226,994,849
JBrowse link
G S100a9 S100 calcium binding protein A9 multiple interactions ISO [zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of S100A9 mRNA CTD PMID:29154782 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation ISO UGT2B7 protein alternative form results in increased glucuronidation of zomepirac; UGT2B7 protein results in increased glucuronidation of zomepirac CTD PMID:8423545, PMID:8517101 NCBI chr14:22,597,103...22,619,968 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        food additive 14685
          food acidity regulator 11586
            acetic acid 10697
              zomepirac 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        monocarboxylic acid 17407
                                          acetic acid 10697
                                            zomepirac 12
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