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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:zomepirac
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Accession:CHEBI:35859 term browser browse the term
Definition:A pyrrole that has formula C15H14ClNO3.
Synonyms:exact_synonym: [5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-yl]acetic acid
 related_synonym: 5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrole-2-acetic acid;   Formula=C15H14ClNO3;   InChI=1S/C15H14ClNO3/c1-9-7-12(8-13(18)19)17(2)14(9)15(20)10-3-5-11(16)6-4-10/h3-7H,8H2,1-2H3,(H,18,19);   InChIKey=ZXVNMYWKKDOREA-UHFFFAOYSA-N;   SMILES=Cc1cc(CC(O)=O)n(C)c1C(=O)c1ccc(Cl)cc1
 xref: Beilstein:487946;   CAS:33369-31-2;   DrugBank:DB04828;   Drug_Central:2871;   LINCS:LSM-6673
 xref_mesh: MESH:C020549
 xref: Wikipedia:Zomepirac


show annotations for term's descendants           Sort by:
 
zomepirac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO zomepirac results in decreased activity of AKR1C2 protein CTD PMID:19010312 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO zomepirac results in decreased activity of AKR1C3 protein CTD PMID:19010312 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Alb albumin affects binding ISO zomepirac binds to ALB protein CTD PMID:6627828 PMID:8027947 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Dhrs11 dehydrogenase/reductase 11 decreases activity ISO zomepirac results in decreased activity of DHRS11 protein CTD PMID:30926317 NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295
JBrowse link
G Glo1 glyoxalase 1 decreases activity ISO zomepirac results in decreased activity of GLO1 protein CTD PMID:17243824 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO [zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of ICAM1 mRNA CTD PMID:29154782 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il1a interleukin 1 alpha multiple interactions
increases expression
ISO [zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of IL1A mRNA; LY6G protein affects the reaction [[zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of IL1A mRNA]
zomepirac metabolite results in increased expression of IL1A
CTD PMID:29154782 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il6 interleukin 6 increases expression ISO zomepirac metabolite results in increased expression of IL6 CTD PMID:29154782 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Lcn2 lipocalin 2 multiple interactions ISO [zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of LCN2 mRNA; LY6G protein affects the reaction [[zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of LCN2 mRNA] CTD PMID:29154782 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Ptgdr2 prostaglandin D2 receptor 2 multiple interactions
affects binding
ISO zomepirac inhibits the reaction [Prostaglandin D2 binds to PTGDR2 protein]
zomepirac binds to PTGDR2 protein
CTD PMID:15563582 NCBI chr 1:207,585,088...207,590,275
Ensembl chr 1:207,587,917...207,589,213
JBrowse link
G S100a9 S100 calcium binding protein A9 multiple interactions ISO [zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of S100A9 mRNA CTD PMID:29154782 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation ISO UGT2B7 protein alternative form results in increased glucuronidation of zomepirac; UGT2B7 protein results in increased glucuronidation of zomepirac CTD PMID:8423545 PMID:8517101 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      application 19481
        food additive 15108
          food acidity regulator 11724
            acetic acid 10853
              zomepirac 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        monocarboxylic acid 17636
                                          acetic acid 10853
                                            zomepirac 12
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