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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:mandelic acid
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Accession:CHEBI:35825 term browser browse the term
Definition:A 2-hydroxy monocarboxylic acid that is acetic acid in which two of the methyl hydrogens are substituted by phenyl and hydroxyl groups.
Synonyms:exact_synonym: hydroxy(phenyl)acetic acid
 related_synonym: (RS)-Mandelic acid;   2-Hydroxy-2-phenylacetic acid;   2-Hydroxy-2-phenylethanoic acid;   DL-Mandelic acid;   Formula=C8H8O3;   InChI=1S/C8H8O3/c9-7(8(10)11)6-4-2-1-3-5-6/h1-5,7,9H,(H,10,11);   InChIKey=IWYDHOAUDWTVEP-UHFFFAOYSA-N;   Mandelsaeure;   SMILES=OC(C(O)=O)c1ccccc1;   alpha-hydroxybenzeneacetic acid
 alt_id: CHEBI:25149;   CHEBI:32801
 xref: Beilstein:510011;   CAS:90-64-2;   Drug_Central:1629;   Gmelin:218213;   HMDB:HMDB0000703
 xref_mesh: MESH:C037938
 xref: PMID:22770225;   PMID:24278065;   PMID:4813698;   Reaxys:510011;   Wikipedia:Mandelic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:25147



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mandelic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO CYP2E1 polymorphism affects the metabolism of [mandelic acid co-treated with phenylglyoxylic acid] CTD PMID:25562543 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Ephx1 epoxide hydrolase 1 multiple interactions ISO EPHX1 polymorphism affects the metabolism of [mandelic acid co-treated with phenylglyoxylic acid] CTD PMID:25562543 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions EXP mandelic acid inhibits the reaction [SLC16A1 protein results in increased transport of Benzoic Acid] CTD PMID:10714609 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
JBrowse link
(S)-mandelic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO CYP2E1 polymorphism affects the metabolism of [mandelic acid co-treated with phenylglyoxylic acid] CTD PMID:25562543 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Ephx1 epoxide hydrolase 1 multiple interactions ISO EPHX1 polymorphism affects the metabolism of [mandelic acid co-treated with phenylglyoxylic acid] CTD PMID:25562543 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions EXP mandelic acid inhibits the reaction [SLC16A1 protein results in increased transport of Benzoic Acid] CTD PMID:10714609 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
JBrowse link
3,4-dihydroxymandelic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase increases methylation ISO COMT protein results in increased methylation of 3,4-dihydroxymandelic acid CTD PMID:11160877 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions EXP 3,4-dihydroxymandelic acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate] CTD PMID:10224140 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
vanillylmandelic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a8 solute carrier family 22 member 8 multiple interactions EXP Vanilmandelic Acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate] CTD PMID:10224140 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    role 19773
      biological role 19773
        antimicrobial agent 17482
          antibacterial agent 13982
            mandelic acid 5
              (R)-mandelic acid 0
              (S)-mandelic acid 3
              3,4-dihydroxymandelic acid 2
              3,4-methylenedioxymandelic acid 0
              3-dimethylallyl-4-hydroxymandelic acid 0
              3-hydroxymandelic acid 0
              4-hydroxymandelic acid + 0
              cyclandelate 0
              ethyl hydroxy(phenyl)acetate + 0
              vanillylmandelic acid 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic group 18739
                              organic divalent group 18730
                                organodiyl group 18730
                                  carbonyl group 18678
                                    carbonyl compound 18678
                                      carboxylic acid 18376
                                        hydroxy carboxylic acid 3654
                                          hydroxy monocarboxylic acid 3654
                                            2-hydroxy monocarboxylic acid 2927
                                              mandelic acid 5
                                                (R)-mandelic acid 0
                                                (S)-mandelic acid 3
                                                3,4-dihydroxymandelic acid 2
                                                3,4-methylenedioxymandelic acid 0
                                                3-dimethylallyl-4-hydroxymandelic acid 0
                                                3-hydroxymandelic acid 0
                                                4-hydroxymandelic acid + 0
                                                cyclandelate 0
                                                ethyl hydroxy(phenyl)acetate + 0
                                                vanillylmandelic acid 1
paths to the root