CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: mandelic acid
Accession: CHEBI:35825
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Definition: A 2-hydroxy monocarboxylic acid that is acetic acid in which two of the methyl hydrogens are substituted by phenyl and hydroxyl groups.
Synonyms: exact_synonym: hydroxy(phenyl)acetic acid
related_synonym: (RS)-Mandelic acid; 2-Hydroxy-2-phenylacetic acid; 2-Hydroxy-2-phenylethanoic acid; DL-Mandelic acid; Formula=C8H8O3; InChI=1S/C8H8O3/c9-7(8(10)11)6-4-2-1-3-5-6/h1-5,7,9H,(H,10,11); InChIKey=IWYDHOAUDWTVEP-UHFFFAOYSA-N; Mandelsaeure; SMILES=OC(C(O)=O)c1ccccc1; alpha-hydroxybenzeneacetic acid
alt_id: CHEBI:25149; CHEBI:32801
xref: Beilstein:510011; CAS:90-64-2; Drug_Central:1629; Gmelin:218213; HMDB:HMDB0000703
xref_mesh: MESH:C037938
xref: PMID:22770225; PMID:24278065; PMID:4813698; Reaxys:510011; Wikipedia:Mandelic_acid
cyclic_relationship: is_conjugate_acid_of CHEBI:25147
G
Alpl
alkaline phosphatase, biomineralization associated
multiple interactions
ISO
[[Volatile Organic Compounds results in increased abundance of Styrene] which results in increased abundance of mandelic acid] which results in increased expression of ALPL protein
CTD
PMID:34668566
NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
G
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
multiple interactions
ISO
CYP2E1 polymorphism affects the metabolism of [mandelic acid co-treated with phenylglyoxylic acid]
CTD
PMID:25562543
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Ephx1
epoxide hydrolase 1
multiple interactions
ISO
EPHX1 polymorphism affects the metabolism of [mandelic acid co-treated with phenylglyoxylic acid]
CTD
PMID:25562543
NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
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Slc16a1
solute carrier family 16 member 1
multiple interactions
EXP
mandelic acid inhibits the reaction [SLC16A1 protein results in increased transport of Benzoic Acid]
CTD
PMID:10714609
NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
G
Alpl
alkaline phosphatase, biomineralization associated
multiple interactions
ISO
[[Volatile Organic Compounds results in increased abundance of Styrene] which results in increased abundance of mandelic acid] which results in increased expression of ALPL protein
CTD
PMID:34668566
NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
G
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
multiple interactions
ISO
CYP2E1 polymorphism affects the metabolism of [mandelic acid co-treated with phenylglyoxylic acid]
CTD
PMID:25562543
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
G
Ephx1
epoxide hydrolase 1
multiple interactions
ISO
EPHX1 polymorphism affects the metabolism of [mandelic acid co-treated with phenylglyoxylic acid]
CTD
PMID:25562543
NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
G
Slc16a1
solute carrier family 16 member 1
multiple interactions
EXP
mandelic acid inhibits the reaction [SLC16A1 protein results in increased transport of Benzoic Acid]
CTD
PMID:10714609
NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
G
Comt
catechol-O-methyltransferase
increases methylation
ISO
COMT protein results in increased methylation of 3,4-dihydroxymandelic acid
CTD
PMID:11160877
NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
G
Slc22a8
solute carrier family 22 member 8
multiple interactions
EXP
3,4-dihydroxymandelic acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]
CTD
PMID:10224140
NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
G
Slc22a8
solute carrier family 22 member 8
multiple interactions
EXP
Vanilmandelic Acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]
CTD
PMID:10224140
NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
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