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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:mandelic acid
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Accession:CHEBI:35825 term browser browse the term
Definition:A 2-hydroxy monocarboxylic acid that is acetic acid in which two of the methyl hydrogens are substituted by phenyl and hydroxyl groups.
Synonyms:exact_synonym: hydroxy(phenyl)acetic acid
 related_synonym: (RS)-Mandelic acid;   2-Hydroxy-2-phenylacetic acid;   2-Hydroxy-2-phenylethanoic acid;   DL-Mandelic acid;   Formula=C8H8O3;   InChI=1S/C8H8O3/c9-7(8(10)11)6-4-2-1-3-5-6/h1-5,7,9H,(H,10,11);   InChIKey=IWYDHOAUDWTVEP-UHFFFAOYSA-N;   Mandelsaeure;   SMILES=OC(C(O)=O)c1ccccc1;   alpha-hydroxybenzeneacetic acid
 alt_id: CHEBI:25149;   CHEBI:32801
 xref: Beilstein:510011;   CAS:90-64-2;   Drug_Central:1629;   Gmelin:218213;   HMDB:HMDB0000703
 xref_mesh: MESH:C037938
 xref: PMID:22770225;   PMID:24278065;   PMID:4813698;   Reaxys:510011;   Wikipedia:Mandelic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:25147


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mandelic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO CYP2E1 polymorphism affects the metabolism of [mandelic acid co-treated with phenylglyoxylic acid] CTD PMID:25562543 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Ephx1 epoxide hydrolase 1 multiple interactions ISO EPHX1 polymorphism affects the metabolism of [mandelic acid co-treated with phenylglyoxylic acid] CTD PMID:25562543 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions EXP mandelic acid inhibits the reaction [SLC16A1 protein results in increased transport of Benzoic Acid] CTD PMID:10714609 NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554
JBrowse link
(S)-mandelic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO CYP2E1 polymorphism affects the metabolism of [mandelic acid co-treated with phenylglyoxylic acid] CTD PMID:25562543 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Ephx1 epoxide hydrolase 1 multiple interactions ISO EPHX1 polymorphism affects the metabolism of [mandelic acid co-treated with phenylglyoxylic acid] CTD PMID:25562543 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions EXP mandelic acid inhibits the reaction [SLC16A1 protein results in increased transport of Benzoic Acid] CTD PMID:10714609 NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554
JBrowse link
3,4-dihydroxymandelic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase increases methylation ISO COMT protein results in increased methylation of 3,4-dihydroxymandelic acid CTD PMID:11160877 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions EXP 3,4-dihydroxymandelic acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate] CTD PMID:10224140 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link
vanillylmandelic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a8 solute carrier family 22 member 8 multiple interactions EXP Vanilmandelic Acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate] CTD PMID:10224140 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        antimicrobial agent 17312
          antibacterial agent 13021
            mandelic acid 5
              (R)-mandelic acid 0
              (S)-mandelic acid 3
              3,4-dihydroxymandelic acid 2
              3,4-methylenedioxymandelic acid 0
              3-dimethylallyl-4-hydroxymandelic acid 0
              3-hydroxymandelic acid 0
              4-hydroxymandelic acid + 0
              cyclandelate 0
              ethyl hydroxy(phenyl)acetate + 0
              vanillylmandelic acid 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        hydroxy carboxylic acid 3603
                                          hydroxy monocarboxylic acid 3603
                                            2-hydroxy monocarboxylic acid 2916
                                              mandelic acid 5
                                                (R)-mandelic acid 0
                                                (S)-mandelic acid 3
                                                3,4-dihydroxymandelic acid 2
                                                3,4-methylenedioxymandelic acid 0
                                                3-dimethylallyl-4-hydroxymandelic acid 0
                                                3-hydroxymandelic acid 0
                                                4-hydroxymandelic acid + 0
                                                cyclandelate 0
                                                ethyl hydroxy(phenyl)acetate + 0
                                                vanillylmandelic acid 1
paths to the root

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