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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:coccidiostat
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Accession:CHEBI:35818 term browser browse the term
Definition:An agent useful in the treatment or prevention of coccidiosis in man or animals.
Synonyms:related_synonym: anticoccidial agent;   coccidiostats



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amprolium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc19a3 solute carrier family 19 member 3 multiple interactions ISO Amprolium inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Amprolium inhibits the reaction [SLC19A3 protein results in increased uptake of Thiamine] CTD PMID:26528626 NCBI chr 9:84,275,722...84,299,368
Ensembl chr 9:84,277,024...84,299,337
JBrowse link
geneticin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression
increases transport
ISO antibiotic G 418 results in decreased expression of ABCB1 mRNA
ABCB1 protein results in increased transport of antibiotic G 418
CTD PMID:20018165 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases transport ISO ABCC1 protein results in increased transport of antibiotic G 418 CTD PMID:20018165 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases transport ISO ABCC2 protein results in increased transport of antibiotic G 418 CTD PMID:20018165 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases transport ISO ABCC3 protein results in increased transport of antibiotic G 418 CTD PMID:20018165 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Atm ATM serine/threonine kinase increases expression ISO antibiotic G 418 results in increased expression of ATM protein mutant form CTD PMID:15498871 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Avpr2 arginine vasopressin receptor 2 multiple interactions ISO antibiotic G 418 results in increased expression of and results in increased activity of AVPR2 protein mutant form CTD PMID:12414899 PMID:14998935 NCBI chr  X:151,633,501...151,636,000
Ensembl chr  X:151,633,522...151,635,989
JBrowse link
G Capn2 calpain 2 increases cleavage ISO antibiotic G 418 results in increased cleavage of CAPN2 protein CTD PMID:15241557 NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
JBrowse link
G Casp12 caspase 12 increases cleavage ISO antibiotic G 418 results in increased cleavage of CASP12 protein CTD PMID:15241557 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp3 caspase 3 increases activity ISO antibiotic G 418 results in increased activity of CASP3 protein CTD PMID:15241557 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
ISO antibiotic G 418 results in increased activity of CASP9 protein
benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [antibiotic G 418 results in increased activity of CASP9 protein]
CTD PMID:15241557 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cftr CF transmembrane conductance regulator increases expression ISO antibiotic G 418 results in increased expression of CFTR protein mutant form CTD PMID:17541014 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G F7 coagulation factor VII multiple interactions ISO antibiotic G 418 results in increased expression of and results in increased activity of F7 protein CTD PMID:16706976 NCBI chr16:76,489,779...76,500,636
Ensembl chr16:76,489,717...76,500,610
JBrowse link
G Gpx1 glutathione peroxidase 1 affects localization ISO antibiotic G 418 affects the localization of GPX1 mRNA mutant form CTD PMID:28743738 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO antibiotic G 418 results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Kcnj1 potassium inwardly-rectifying channel, subfamily J, member 1 increases expression ISO antibiotic G 418 results in increased expression of KCNJ1 protein mutant form CTD PMID:12911542 NCBI chr 8:30,779,883...30,808,607
Ensembl chr 8:30,753,617...30,813,796
JBrowse link
G Mmut methylmalonyl-CoA mutase affects expression
multiple interactions
ISO antibiotic G 418 affects the expression of MMUT mRNA mutant form
[antibiotic G 418 co-treated with Gentamicins] affects the activity of MMUT protein mutant form; [antibiotic G 418 co-treated with Gentamicins] affects the expression of MMUT mRNA mutant form; antibiotic G 418 promotes the reaction [Gentamicins affects the expression of MMUT protein mutant form]
CTD PMID:19427250 NCBI chr 9:19,928,720...19,956,985
Ensembl chr 9:19,928,727...19,957,046
JBrowse link
G Slc4a4 solute carrier family 4 member 4 increases expression ISO antibiotic G 418 results in increased expression of SLC4A4 protein mutant form CTD PMID:18614622 NCBI chr14:18,841,289...19,293,297
Ensembl chr14:18,845,159...19,272,883
JBrowse link
G Smn1 survival of motor neuron 1, telomeric increases expression ISO antibiotic G 418 results in increased expression of SMN2 protein CTD PMID:19150990 NCBI chr 2:31,490,018...31,501,065
Ensembl chr 2:31,490,015...31,501,060
JBrowse link
G Upf1 UPF1, RNA helicase and ATPase affects localization ISO antibiotic G 418 affects the localization of UPF1 protein CTD PMID:28743738 NCBI chr16:19,076,594...19,097,365
Ensembl chr16:19,076,322...19,096,568
JBrowse link
lasalocid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mapt microtubule-associated protein tau decreases expression ISO Lasalocid results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
monensin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase copper transporting alpha multiple interactions ISO Monensin inhibits the reaction [ATP7A protein affects the localization of Doxorubicin] CTD PMID:17510416 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354
JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression ISO Monensin results in increased expression of BNIP3 protein CTD PMID:30718715 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Lithium inhibits the reaction [Monensin results in increased activity of CASP3 protein] CTD PMID:20799912 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO Lithium inhibits the reaction [Monensin results in increased activity of CASP7 protein] CTD PMID:20799912 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Monensin inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Monensin inhibits the reaction [Quercetin results in increased secretion of CSF2 protein] CTD PMID:18346843 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Egf epidermal growth factor multiple interactions EXP [EGF protein co-treated with Monensin] results in increased expression of MYC mRNA CTD PMID:12632255 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Il6 interleukin 6 decreases secretion ISO Monensin results in decreased secretion of IL6 protein CTD PMID:11216681 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions EXP [EGF protein co-treated with Monensin] results in increased expression of MYC mRNA CTD PMID:12632255 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Monensin results in increased cleavage of PARP1 protein CTD PMID:30718715 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Slc6a2 solute carrier family 6 member 2 multiple interactions ISO Monensin promotes the reaction [para-methyl-4-methylaminorex inhibits the reaction [SLC6A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]] CTD PMID:29908239 NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO Monensin promotes the reaction [para-methyl-4-methylaminorex inhibits the reaction [SLC6A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]] CTD PMID:29908239 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions ISO Monensin promotes the reaction [para-methyl-4-methylaminorex inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]] CTD PMID:29908239 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
JBrowse link
G Trpm2 transient receptor potential cation channel, subfamily M, member 2 decreases expression
increases expression
multiple interactions
ISO Monensin results in decreased expression of TRPM2 protein alternative form
Monensin results in increased expression of TRPM2 protein alternative form
Lithium inhibits the reaction [Monensin results in increased expression of TRPM2 protein alternative form]
CTD PMID:20799912 NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 increases response to substance ISO ZEB1 protein results in increased susceptibility to Monensin CTD PMID:30718715 NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214
JBrowse link
roxarsone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Angpt1 angiopoietin 1 decreases expression ISO Roxarsone results in decreased expression of ANGPT1 mRNA CTD PMID:18414637 NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067
JBrowse link
G Cnmd chondromodulin decreases expression ISO Roxarsone results in decreased expression of CNMD mRNA CTD PMID:18414637 NCBI chr15:55,041,548...55,066,297
Ensembl chr15:55,041,561...55,066,297
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 decreases expression ISO Roxarsone results in decreased expression of CXCL9 mRNA CTD PMID:18414637 NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435
JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 increases secretion ISO Roxarsone results in increased secretion of ENPP2 protein CTD PMID:22952646 NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827
JBrowse link
G Fhdc1 FH2 domain containing 1 decreases expression ISO Roxarsone results in decreased expression of INF1 mRNA CTD PMID:18414637 NCBI chr 2:169,790,917...169,829,580
Ensembl chr 2:169,790,947...169,827,896
JBrowse link
G Hgf hepatocyte growth factor increases expression ISO Roxarsone results in increased expression of HGF mRNA CTD PMID:18414637 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Lep leptin decreases expression ISO Roxarsone results in decreased expression of LEP mRNA CTD PMID:18414637 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression ISO Roxarsone results in increased expression of MMP9 mRNA; Roxarsone results in increased expression of MMP9 protein CTD PMID:22952646 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO Roxarsone results in increased phosphorylation of and results in increased activity of NOS3 protein CTD PMID:18414637 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 increases expression
multiple interactions
ISO Roxarsone results in increased expression of PECAM1 protein
Semaxinib inhibits the reaction [Roxarsone results in increased expression of PECAM1 protein]
CTD PMID:30028964 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
JBrowse link
G Plg plasminogen decreases expression ISO Roxarsone results in decreased expression of PLG mRNA CTD PMID:18414637 NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP Roxarsone results in increased expression of and results in increased secretion of VEGFA protein CTD PMID:24035937 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
sulfadiazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases hydroxylation ISO CYP2C8 protein results in increased hydroxylation of Sulfadiazine CTD PMID:15843491
G Hmbs hydroxymethylbilane synthase decreases activity EXP Sulfadiazine decreases activity of purified Hmbs protein RGD PMID:6893114 RGD:26923963 NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Trimethoprim co-treated with Sulfadiazine] results in increased expression of IL6 protein CTD PMID:10888991 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nat2 N-acetyltransferase 2 increases acetylation ISO NAT2 protein results in increased acetylation of Sulfadiazine CTD PMID:15843491 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20050
    role 20001
      biological role 20000
        antimicrobial agent 17759
          antimicrobial drug 8735
            antiprotozoal drug 7023
              coccidiostat 49
                amprolium 1
                amprolium(1+) + 1
                geneticin 19
                lasalocid 1
                lasalocid sodium 0
                monensin A 14
                roxarsone 12
                sulfadiazine 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 20050
    role 20001
      application 19737
        pharmaceutical 19610
          drug 19610
            antiinfective agent 14202
              antiparasitic agent 9336
                antiprotozoal drug 7023
                  coccidiostat 49
                    amprolium 1
                    amprolium(1+) + 1
                    geneticin 19
                    lasalocid 1
                    lasalocid sodium 0
                    monensin A 14
                    roxarsone 12
                    sulfadiazine 4
paths to the root