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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:roxarsone
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Accession:CHEBI:35817 term browser browse the term
Definition:An organoarsonic acid where the organyl group is 4-hydroxy-3-nitrophenyl.
Synonyms:exact_synonym: (4-hydroxy-3-nitrophenyl)arsonic acid
 related_synonym: 2-nitro-1-hydroxybenzene-4-arsonic acid;   3-Nitro;   3-nitro-4-hydroxybenzenearsonic acid;   3-nitro-4-hydroxyphenylarsonic acid;   4-hydroxy-3-nitrobenzenearsonic acid;   4-hydroxy-3-nitrophenylarsonic acid;   Formula=C6H6AsNO6;   InChI=1S/C6H6AsNO6/c9-6-2-1-4(7(10,11)12)3-5(6)8(13)14/h1-3,9H,(H2,10,11,12);   InChIKey=XMVJITFPVVRMHC-UHFFFAOYSA-N;   NSC-2101;   Ren-O-Sal;   SMILES=Oc1ccc(cc1[N+]([O-])=O)[As](O)(O)=O;   roxarson;   roxarsonum
 xref: Beilstein:1976533;   CAS:121-19-7;   Gmelin:1221211;   LINCS:LSM-5383
 xref_mesh: MESH:D012406
 xref: PMID:12724787;   PMID:12731831;   PMID:12731832;   PMID:18414637;   PMID:21388897;   Patent:DE224953;   Patent:GB226255;   Reaxys:1976533;   VSDB:3003;   Wikipedia:Roxarsone


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roxarsone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Angpt1 angiopoietin 1 decreases expression ISO Roxarsone results in decreased expression of ANGPT1 mRNA CTD PMID:18414637 NCBI chr15:42,288,063...42,540,373
Ensembl chr15:42,288,119...42,540,373 		JBrowse link
G Cnmd chondromodulin decreases expression ISO Roxarsone results in decreased expression of CNMD mRNA CTD PMID:18414637 NCBI chr14:79,875,126...79,899,596
Ensembl chr14:79,875,130...79,899,610 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 decreases expression ISO Roxarsone results in decreased expression of CXCL9 mRNA CTD PMID:18414637 NCBI chr 5:92,469,190...92,475,938
Ensembl chr 5:92,469,206...92,475,938 		JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 increases secretion ISO Roxarsone results in increased secretion of ENPP2 protein CTD PMID:22952646 NCBI chr15:54,702,297...54,816,284
Ensembl chr15:54,702,297...54,816,288 		JBrowse link
G Fhdc1 FH2 domain containing 1 decreases expression ISO Roxarsone results in decreased expression of INF1 mRNA CTD PMID:18414637 NCBI chr 3:84,349,503...84,387,746
Ensembl chr 3:84,349,505...84,387,736 		JBrowse link
G Hgf hepatocyte growth factor increases expression ISO Roxarsone results in increased expression of HGF mRNA CTD PMID:18414637 NCBI chr 5:16,758,493...16,827,448
Ensembl chr 5:16,758,493...16,825,150 		JBrowse link
G Lep leptin decreases expression ISO Roxarsone results in decreased expression of LEP mRNA CTD PMID:18414637 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression ISO Roxarsone results in increased expression of MMP9 mRNA; Roxarsone results in increased expression of MMP9 protein CTD PMID:22952646 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Mtor mechanistic target of rapamycin kinase increases expression
multiple interactions		 ISO Roxarsone results in increased expression of MTOR mRNA
Roxarsone results in increased expression of and results in increased phosphorylation of MTOR protein; Sirolimus inhibits the reaction [Roxarsone results in increased expression of and results in increased phosphorylation of MTOR protein]		 CTD PMID:35985552 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell multiple interactions ISO Roxarsone results in increased phosphorylation of and results in increased activity of NOS3 protein CTD PMID:18414637 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Pecam1 platelet/endothelial cell adhesion molecule 1 multiple interactions
increases expression		 EXP Semaxinib inhibits the reaction [Roxarsone results in increased expression of PECAM1 protein] CTD PMID:30028964 NCBI chr11:106,545,039...106,606,107
Ensembl chr11:106,545,043...106,641,454 		JBrowse link
G Plg plasminogen decreases expression ISO Roxarsone results in decreased expression of PLG mRNA CTD PMID:18414637 NCBI chr17:12,597,496...12,638,271
Ensembl chr17:12,597,495...12,638,272 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 multiple interactions
increases expression		 ISO Roxarsone results in increased expression of and results in increased phosphorylation of RPS6KB1 protein; Sirolimus inhibits the reaction [Roxarsone results in increased expression of and results in increased phosphorylation of RPS6KB1 protein]
Roxarsone results in increased expression of RPS6KB1 mRNA		 CTD PMID:35985552 NCBI chr11:86,389,695...86,435,711
Ensembl chr11:86,389,697...86,435,631 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Roxarsone results in increased expression of and results in increased secretion of VEGFA protein CTD PMID:24035937 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22194
    role 22179
      application 21760
        agrochemical 16967
          roxarsone 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 22194
    subatomic particle 22186
      composite particle 22186
        hadron 22186
          baryon 22186
            nucleon 22186
              atomic nucleus 22186
                atom 22186
                  main group element atom 22120
                    p-block element atom 22120
                      chalcogen 21446
                        oxygen atom 21425
                          oxygen molecular entity 21425
                            hydroxides 20801
                              oxoacid 20115
                                pnictogen oxoacid 13702
                                  arsenic oxoacid 4422
                                    arsonic acids 751
                                      arsonic acid 751
                                        organoarsonic acid 751
                                          phenylarsonic acid 16
                                            roxarsone 14
paths to the root